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Humeral head deviation and velocity in multidirectional instability of the glenohumeral joint: a cine magnetic resonance imaging study 肱骨关节多向不稳定中的肱骨头偏移和速度:一项电影磁共振成像研究
Q2 Medicine Pub Date : 2025-12-02 DOI: 10.1016/j.jseint.2025.101419
Kazuhisa Matsui PT, PhD, MSc , Takashi Tachibana PT , Katsuya Nobuhara MD, PhD , Yasushi Uchiyama PT, PhD

Background

Manual clinical tests for shoulder instability rely heavily on subjective assessments of humeral head translation, making objective quantification challenging. This study hypothesized that patients with multidirectional glenohumeral instability (MDI) would demonstrate greater humeral head deviation and faster deviation velocity than healthy controls during active shoulder rotation, as assessed using cine magnetic resonance imaging (MRI).

Methods

Fourteen participants (eight shoulders with MDI and 20 healthy shoulders) underwent cine MRI while performing active shoulder rotation with the arm at the side. Humeral head deviation, deviation amplitude, and deviation velocity were calculated and compared between the groups using Welch's t-test.

Results

The MDI group showed significantly greater humeral head deviation, wider amplitude of deviation, and faster deviation velocity than the control group (P = .008 for anterior deviation, P = .009 for posterior deviation). The deviation amplitude exceeded 35% of the glenoid width in MDI shoulders, surpassing established clinical thresholds.

Conclusion

Patients with MDI demonstrated quantifiable dynamic instability on cine MRI. This modality may provide objective support for clinical findings. However, validation in larger cohorts is warranted to confirm these findings, given the limited number of MDI shoulders (n = 8).
背景:肩关节不稳定的手工临床试验在很大程度上依赖于对肱骨头平移的主观评估,使得客观量化具有挑战性。通过电影磁共振成像(MRI)评估,本研究假设患有多向肩关节不稳定(MDI)的患者在主动肩关节旋转时比健康对照者表现出更大的肱骨头偏移和更快的偏移速度。方法14例受试者(8例MDI肩关节和20例健康肩关节)在进行主动肩关节侧旋时行MRI检查。采用Welch’st检验计算组间肱骨头偏差、偏差幅度、偏差速度。结果与对照组相比,MDI组肱骨头偏大、偏幅宽、偏速快(前偏P = 0.008,后偏P = 0.009)。MDI患者的偏离幅度超过肩关节盂宽度的35%,超过了既定的临床阈值。结论MDI患者在MRI上表现出可量化的动态不稳定性。这种模式可以为临床结果提供客观支持。然而,考虑到MDI肩胛骨数量有限(n = 8),需要在更大的队列中进行验证以证实这些发现。
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引用次数: 0
Optimizing tendon-to-bone healing: a comparative study of intratunnel and anatomical repairs in rotator cuff tears 优化肌腱-骨愈合:隧道内修复和解剖修复肩袖撕裂的比较研究
Q2 Medicine Pub Date : 2025-12-02 DOI: 10.1016/j.jseint.2025.101425
Muzaffer Agir MD , Koray Sahin MD , Anil Pulatkan MD , Mehmet Kapicioglu MD , Fatih Yamak PhD , Ergun Bozdağ PhD , Ayse Nur Toksoz Yildirim MD , Kerem Bilsel MD

Background

Rotator cuff tears are a leading cause of shoulder pain, with high rerupture rates despite advancements in surgical techniques. Tendon-to-bone healing failure is often attributed to insufficient fibrocartilage regeneration at the repair site. Intratunnel repair (TR) has been proposed as an alternative approach to enhance healing by increasing tendon-bone contact and exposure to marrow-derived stem cells. However, its effectiveness in chronic rotator cuff tears remains unclear. This study aims to compare the biomechanical and histological outcomes of TR and surface repair (SR) in a rabbit model. We hypothesized that TR might offer advantages in tendon-to-bone healing compared to SR, particularly through enhanced contact area and marrow exposure.

Methods

A chronic rotator cuff tear model was created in 36 New Zealand White rabbits by tenotomizing the subscapularis tendon and preventing spontaneous healing for 8 weeks. The right shoulders underwent TR, while the left shoulders received SR. Biomechanical and histological evaluations were performed at 4, 8, and 12 weeks postrepair. Biomechanical testing assessed failure load, stiffness, and elongation. Histological assessments included collagen fiber organization, fibrocartilage formation, vascularity, and tendon maturation using Modified Watson tendon maturation scoring. Statistical analyses were conducted using nonparametric tests with a significance level of P < .05.

Results

Biomechanical results showed no significant differences in failure load between TR and SR at any time point (P = .423, P = .423, P = .631). However, at 12 weeks, the stiffness of TR was significantly higher than SR (P = .005). Early histological findings showed similar tendon maturation, collagen alignment, and vascularity in both groups. By 12 weeks, the SR group exhibited significantly better collagen organization (P = .006), vascularity (P = .002), and Modified Watson tendon maturation score (P = .004) compared to TR. The tidemark line, a key indicator of fibrocartilage development, was observed in all SR samples at 12 weeks but was absent in most TR specimens.

Discussion

Contrary to our hypothesis, TR did not demonstrate superior healing outcomes compared to SR. While TR provided similar biomechanical properties, its histological outcomes were inferior over time. We speculate that increased inflammatory response and tendon micromotion within the tunnel may have contributed to the inferior histological healing observed in the TR group.

Conclusion

These findings suggest that TR does not offer significant advantages over SR in chronic rotator cuff tears. Further studies are needed to optimize healing strategies within the bone tunnel.
背景:肩袖撕裂是肩痛的主要原因,尽管手术技术进步,但其再破裂率很高。肌腱到骨愈合失败通常归因于修复部位纤维软骨再生不足。隧道内修复(TR)被认为是一种通过增加肌腱-骨接触和暴露于骨髓来源的干细胞来增强愈合的替代方法。然而,其治疗慢性肩袖撕裂的有效性尚不清楚。本研究旨在比较兔TR和表面修复(SR)模型的生物力学和组织学结果。我们假设与SR相比,TR可能在肌腱-骨愈合方面具有优势,特别是通过增加接触面积和骨髓暴露。方法以36只新西兰大白兔为实验动物,采用肩胛下肌腱断裂术并阻止其自愈8周,建立慢性肩袖撕裂模型。右肩接受TR,左肩接受sr。在修复后4周、8周和12周进行生物力学和组织学评估。生物力学测试评估失效载荷、刚度和伸长率。组织学评估包括胶原纤维组织、纤维软骨形成、血管分布和使用改良沃森肌腱成熟评分的肌腱成熟。采用非参数检验进行统计学分析,显著性水平为P <; 0.05。结果生物力学结果显示,各时间点TR和SR的失效负荷无显著差异(P = .423, P = .423, P = .631)。然而,在12周时,TR的僵硬度显著高于SR (P = 0.005)。早期组织学结果显示两组肌腱成熟、胶原排列和血管分布相似。到12周时,与TR相比,SR组的胶原组织(P = 0.006)、血管密度(P = 0.002)和改良沃森肌腱成熟评分(P = 0.004)明显更好。12周时,所有SR样本中都观察到潮汐线,这是纤维软骨发育的关键指标,但大多数TR样本中没有。与我们的假设相反,与sr相比,TR没有表现出更好的愈合结果。虽然TR提供了相似的生物力学特性,但随着时间的推移,其组织学结果较差。我们推测,隧道内炎症反应和肌腱微运动的增加可能导致了TR组中观察到的较差的组织学愈合。结论在治疗慢性肩袖撕裂时,TR并不比SR有明显的优势。需要进一步的研究来优化骨隧道内的愈合策略。
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引用次数: 0
Persistent scapular dyskinesis after arthroscopic rotator cuff repair: a prospective study 关节镜下肩袖修复后持续性肩胛骨运动障碍:一项前瞻性研究
Q2 Medicine Pub Date : 2025-12-02 DOI: 10.1016/j.jseint.2025.101420
Michele Mercurio MD , Erminia Cofano MD , Claudia Mancuso MD , Lorena Paola MD , Alessandro Imbrogno PhD Student , Matteo Mantovani MSc , Filippo Familiari MD , Giorgio Gasparini MD , Olimpio Galasso MD

Background

The supraspinatus plays a critical role in stabilizing the glenohumeral joint and facilitating arm elevation. The biomechanical disruption caused by supraspinatus tears changes the normal force couple balance between the deltoid and rotator cuff muscles, often resulting in superior migration of the humeral head and altered scapulohumeral rhythm (SHR). This study aims to prospectively compare the shoulder kinematics of patients preoperatively and after arthroscopic rotator cuff repair using magnetic inertial measurement units with a motion analysis system.

Methods

A prospective study was conducted with data collection on 21 patients who underwent shoulder arthroscopy for rotator cuff tear repair. Preoperatively and at a minimum 12-month follow-up, each patient was evaluated using the range of motion (ROM) assessment and the Constant–Murley Score (CMS). Patients were examined using the ShowMotion 3D kinematic tracking system (NCS Lab, Modena, Italy), which uses wireless wearable noninvasive magnetic and inertial measurement units sensors to assess the three-dimensional kinematics of the shoulder. For each plane of elevation (ie, flexion and abduction), the SHR was described by 3 scapulothoracic rotations (ie, protraction–retraction, mediolateral rotation, and posterior–anterior tilting) as a function of humeral anteflexion or humeral abduction.

Results

Active flexion and external rotation ROM showed statistically significant improvement (P = .039 and P = .006, respectively). CMS pain, strength, and total showed statistically significant improvement (P = .039 and P = .006, respectively). All the patients showed a nonstatistically significant difference of the SHR along the entire ROM between pre- and postoperative evaluation. The P value in flexion and abduction was >.05; the only statistically significant value was on tilt at 60° in flexion (P = .044)

Conclusion

A persistent scapular dyskinesis was observed after arthroscopic rotator cuff repair. Despite a statistically significant improvement reported for active flexion, active external rotation, and for the total CMS, scapular dyskinesis is not resolved with surgery and may contribute to worse long-term outcomes. Further biomechanical and clinical research studies are needed to define specific rehabilitation programs, to maximize outcomes, and to prevent possible cause of reinjury of the rotator cuff repaired.
冈上肌在稳定盂肱关节和促进手臂抬高方面起着关键作用。冈上肌撕裂引起的生物力学破坏改变了三角肌和肩袖肌之间的正常力偶平衡,通常导致肱骨头上向移位和肩胛骨节律(SHR)改变。本研究旨在前瞻性地比较关节镜下肩袖修复术术前和术后患者的肩关节运动学,采用磁惯性测量单元和运动分析系统。方法对21例经肩关节镜治疗肩袖撕裂的患者进行前瞻性研究。术前和至少12个月的随访中,使用活动度(ROM)评估和Constant-Murley评分(CMS)对每位患者进行评估。患者使用ShowMotion 3D运动学跟踪系统(NCS实验室,意大利摩德纳)进行检查,该系统使用无线可穿戴无创磁和惯性测量单元传感器来评估肩部的三维运动学。对于每个上升平面(即屈曲和外展),SHR通过3次肩胸旋转(即伸-收,中外侧旋转和前后倾斜)作为肱骨前屈或肱骨外展的功能来描述。结果主动屈曲和外旋ROM均有显著改善(P = 0.039和P = 0.006)。CMS疼痛、力量、总分均有统计学意义的改善(P = 0.039、P = 0.006)。在术前和术后评估中,所有患者沿整个ROM的SHR均显示无统计学意义的差异。屈曲和外展的P值为>;结论关节镜下肩袖修复术后出现持续性肩胛骨运动障碍。尽管主动屈曲、主动外旋和全CMS有统计学上的显著改善,但肩胛骨运动障碍不能通过手术解决,并可能导致更差的长期预后。需要进一步的生物力学和临床研究来确定具体的康复方案,以最大限度地提高疗效,并防止修复后的肩袖再损伤的可能原因。
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引用次数: 0
Proxy for the surgery for elbow osteochondritis dissecans in adolescent baseball players 替代青少年棒球运动员肘关节骨软骨炎的手术
Q2 Medicine Pub Date : 2025-12-02 DOI: 10.1016/j.jseint.2025.101424
Masataka Minami PhD, MD , Yoshikazu Kida PhD, MD , Masamitsu Kido PhD, MD , Ausberto R. Velasquez Garcia MD , Jesse B. O'Driscoll BS , James S. Fitzsimmons BSc , Kenji Takahashi PhD, MD , Shawn W. O'Driscoll PhD, MD

Background

Capitellar osteochondritis dissecans (OCD) is a disorder frequently affecting adolescent athletes and can lead to chronic disability or surgery. While preventive measures have been advocated, there is no established method to monitor the prevalence of OCD. This study aimed to validate the use of surgical codes from the Japanese national database as proxies for OCD.

Methods

A retrospective epidemiological analysis was conducted using the Japanese national claims database from 2014 to 2022. Surgical procedures potentially linked to OCD, including drilling, bone débridement, synovectomy, and loose-body removal were analyzed by age, sex, and geographic distribution. Bibliometric data on OCD-related publications were extracted to assess their correlation with regional surgical incidence. Statistical analyses were performed to evaluate the validity of these surgical codes as proxies for OCD.

Results

Loose-body removal was the most strongly associated with OCD, with 97% of procedures performed on males and 64% on patients under 20 years of age. Significant regional variation was observed, with Tokushima Prefecture showing the highest incidence of loose-body removal, mirroring its strong publication record on this topic. In contrast, drilling and bone débridement showed weaker demographic alignment with OCD and no significant correlation with publication activity. Synovectomy demonstrated moderate regional alignment but lacked demographic specificity for OCD.

Conclusion

This study highlights the utility of surgical codes from the national database in approximating OCD epidemiology, with loose-body removal serving as a reliable proxy. These findings establish a foundation for future studies to assess preventive strategies and guide resource allocation for OCD management in youth athletes.
背景:夹层小头骨软骨炎(OCD)是一种经常影响青少年运动员的疾病,可导致慢性残疾或手术。虽然一直提倡采取预防措施,但没有确定的方法来监测强迫症的流行情况。本研究旨在验证使用日本国家数据库中的外科代码作为强迫症的代理。方法对2014 - 2022年日本国家理赔数据库进行回顾性流行病学分析。可能与强迫症相关的外科手术,包括钻孔、骨质清除、滑膜切除术和松体切除,按年龄、性别和地理分布进行了分析。提取强迫症相关出版物的文献计量学数据,以评估其与区域手术发生率的相关性。进行统计分析以评估这些外科代码作为强迫症代理的有效性。结果游离体切除与强迫症的关系最为密切,97%的患者为男性,64%的患者年龄在20岁以下。观察到显著的地区差异,德岛县显示出最高的游离体移除率,反映了其在这一主题上的良好出版记录。相比之下,钻孔和骨质疏松与强迫症的人口统计学相关性较弱,与出版活动无显著相关性。滑膜切除术显示出适度的区域一致性,但缺乏强迫症的人口统计学特异性。结论本研究强调了来自国家数据库的手术代码在近似强迫症流行病学方面的实用性,其中松体切除可作为可靠的代理。这些发现为未来的研究评估青少年运动员强迫症的预防策略和指导资源分配奠定了基础。
{"title":"Proxy for the surgery for elbow osteochondritis dissecans in adolescent baseball players","authors":"Masataka Minami PhD, MD ,&nbsp;Yoshikazu Kida PhD, MD ,&nbsp;Masamitsu Kido PhD, MD ,&nbsp;Ausberto R. Velasquez Garcia MD ,&nbsp;Jesse B. O'Driscoll BS ,&nbsp;James S. Fitzsimmons BSc ,&nbsp;Kenji Takahashi PhD, MD ,&nbsp;Shawn W. O'Driscoll PhD, MD","doi":"10.1016/j.jseint.2025.101424","DOIUrl":"10.1016/j.jseint.2025.101424","url":null,"abstract":"<div><h3>Background</h3><div>Capitellar osteochondritis dissecans (OCD) is a disorder frequently affecting adolescent athletes and can lead to chronic disability or surgery. While preventive measures have been advocated, there is no established method to monitor the prevalence of OCD. This study aimed to validate the use of surgical codes from the Japanese national database as proxies for OCD.</div></div><div><h3>Methods</h3><div>A retrospective epidemiological analysis was conducted using the Japanese national claims database from 2014 to 2022. Surgical procedures potentially linked to OCD, including drilling, bone débridement, synovectomy, and loose-body removal were analyzed by age, sex, and geographic distribution. Bibliometric data on OCD-related publications were extracted to assess their correlation with regional surgical incidence. Statistical analyses were performed to evaluate the validity of these surgical codes as proxies for OCD.</div></div><div><h3>Results</h3><div>Loose-body removal was the most strongly associated with OCD, with 97% of procedures performed on males and 64% on patients under 20 years of age. Significant regional variation was observed, with Tokushima Prefecture showing the highest incidence of loose-body removal, mirroring its strong publication record on this topic. In contrast, drilling and bone débridement showed weaker demographic alignment with OCD and no significant correlation with publication activity. Synovectomy demonstrated moderate regional alignment but lacked demographic specificity for OCD.</div></div><div><h3>Conclusion</h3><div>This study highlights the utility of surgical codes from the national database in approximating OCD epidemiology, with loose-body removal serving as a reliable proxy. These findings establish a foundation for future studies to assess preventive strategies and guide resource allocation for OCD management in youth athletes.</div></div>","PeriodicalId":34444,"journal":{"name":"JSES International","volume":"10 2","pages":"Article 101424"},"PeriodicalIF":0.0,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk factors for retear of arthroscopic rotator cuff repair using triple-row technique 关节镜下三排技术肩袖修复术后复发的危险因素
Q2 Medicine Pub Date : 2025-12-02 DOI: 10.1016/j.jseint.2025.101412
Ryosuke Takahashi MD , Ryosuke Sagami MD , Yohei Harada MD, PhD , Yukihiro Kajita MD, PhD

Background

The triple-row (TR) technique enhances tendon-to-bone contact and repair integrity in arthroscopic rotator cuff repair (ARCR). However, limited studies have evaluated the clinical outcomes and risk factors for retears following this technique. This study aimed to compare clinical outcomes between retear and nonretear groups after ARCR using the TR technique and identify risk factors for retear.

Methods

Patients who underwent ARCR using the TR technique with at least 24 months follow-up were enrolled and categorized into retear and nonretear groups. Clinical outcomes, including range of motion, visual analog scale for pain, Constant Shoulder (CS), and University of California Los Angeles (UCLA) score, were evaluated at 3, 6, and 24 months postoperatively. The retear rate and tendon integrity were assessed at 3, 6, and 24 months follow-up using magnetic resonance imaging, and risk factors for retear were analyzed.

Results

Of 181 patients enrolled, 20 (11%) had retears and 161 (89%) had no retears. The retear group was significantly older (P = .037) and had more large or massive tears (P = .044), larger tear sizes on magnetic resonance imaging (coronal plane: 29.9 ± 14.9 mm vs. 21.6 ± 12 mm, P = .005; sagittal plane: 23.7 ± 12.1 mm vs. 17.9 ± 9.4 mm, P = .013), and greater fatty infiltration (P < .001). Both groups achieved good clinical outcomes, but the retear group showed significantly lower CS and UCLA scores at 6 and 24 months (CS score: 72.4 ± 9 point vs. 78.6 ± 8.6 point at 6 months [P = .004] and 81.2 ± 11.1 point vs. 86.3 ± 9.6 point at 24 months [P = .032]; UCLA score: 25 ± 2.6 point vs. 27.3 ± 3.5 point at 6 months [P = .005], 28.7 ± 4.6 point vs. 30.9 ± 3.7 point at 24 months [P = .018]) and higher visual analog scale scores at 24 months (21.5 ± 12 vs. 7.8 ± 7.7, P = .021). Fatty infiltration of the infraspinatus was identified as an independent risk factor for retears. Patients with Goutallier grade ≥3 had significantly inferior external rotation at 3 and 6 months (26 ± 25.1° vs. 44.7 ± 11.4°, P = .032, 35 ± 28.3° vs. 53 ± 9°, P = .038) and tended to show inferior outcomes overall.

Conclusion

ARCR using the TR technique provides favorable clinical outcomes, even in cases with retears. However, patients with retears—especially those with large-to-massive tears or severe infraspinatus fatty infiltration—showed inferior outcomes.
背景:在关节镜下肩袖修复(ARCR)中,三排(TR)技术增强了肌腱与骨的接触和修复的完整性。然而,有限的研究已经评估了这种技术的临床结果和风险因素。本研究的目的是比较使用TR技术进行ARCR后复发组和非复发组的临床结果,并确定复发的危险因素。方法采用TR技术行ARCR且随访至少24个月的患者入组,分为复发组和非复发组。临床结果包括术后3、6和24个月的活动范围、疼痛视觉模拟量表、恒肩(CS)和加州大学洛杉矶分校(UCLA)评分。随访3个月、6个月和24个月时,采用磁共振成像技术评估患者的再撕率和肌腱完整性,并分析再撕的危险因素。结果入组的181例患者中,20例(11%)有流泪,161例(89%)无流泪。撕裂组明显年龄大(P = 0.037),撕裂较大或块状(P = 0.044),磁共振成像撕裂尺寸较大(冠状面:29.9±14.9 mm vs. 21.6±12 mm, P = 0.005;矢状面:23.7±12.1 mm vs. 17.9±9.4 mm, P = 0.013),脂肪浸润较大(P < 0.001)。两组取得了良好的临床结果,但retear组显示显著降低CS和加州大学洛杉矶分校的分数在6到24个月(CS得分:72.4±9点和78.6±8.6点在6个月(P = 04)和81.2±11.1点和86.3±9.6点在24个月(P = .032),加州大学洛杉矶分校得分:25±2.6点和27.3±3.5点在6个月[P = .005], 28.7±4.6点和30.9±3.7点24个月[P = .018])和更高的视觉模拟量表得分在24个月(12和21.5±7.8±7.7,P = .021)。冈下肌脂肪浸润被认为是复发的独立危险因素。Goutallier分级≥3的患者在3个月和6个月时外旋明显较差(26±25.1°对44.7±11.4°,P = 0.032, 35±28.3°对53±9°,P = 0.038),总体结果较差。结论应用TR技术的arcr具有良好的临床效果,即使在有裂孔的病例中也是如此。然而,裂口患者,特别是那些大到大块的裂口或严重的冈下脂肪浸润的患者,其预后较差。
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引用次数: 0
Subcutaneous tissue disinfection is more effective than the use of electrocautery in reducing Cutibacterium acnes burden in open shoulder surgery 在开放性肩部手术中,皮下组织消毒比电灼更有效地减少痤疮表皮杆菌的负担
Q2 Medicine Pub Date : 2025-12-02 DOI: 10.1016/j.jseint.2025.101408
Nicolas Gallusser MD , Bertrand Léger PhD , Caroline Passaplan MD , Stéphane Emonet MD , Beat Kaspar Moor PD

Background

Cutibacterium acnes (C. acnes) is a pathogen linked to infections following shoulder surgery. Exposure can occur during surgical dissection and spread in the surgical field through the surgeon's gloves and instruments. Disinfection of the subcutaneous tissue has been shown to reduce its contamination. No evidence has been provided for a decrease in the transmission rate when the dissection is performed with an electrocautery. The aim of this study was to ascertain whether disinfection of subcutaneous tissue can reduce the C. acnes rate in primary open shoulder surgery in comparison with dissection performed with electrocautery. We also wanted to compare the contamination rate of the operating field after electrocautery dissection with those found in the literature.

Methods

All patients who qualified for primary open shoulder surgery via a deltopectoral approach were prospectively included in our single-blinded, two-arm randomized clinical trial. For every patient, a skin swab from the surgical area was taken before the standard preparation of the skin. In the disinfection group, the subcutaneous layer was treated with povidone iodine solution after exposure of the deltoid fascia. The cautery group underwent subcutaneous tissue dissection using an electrocautery. After fully exposing the proximal humerus, 5 swabs were collected from various locations for microbiological analysis, following a rigorous protocol. All cultures were incubated for 14 days under both aerobic and anaerobic conditions.

Results

Between February 2020 and July 2021, 210 shoulders were enrolled in 2 groups (140 disinfection vs. 70 cautery). The 2 groups showed no significant differences in terms of sex, age, body mass index, or diabetes prevalence. The subcutaneous disinfection protocol led to a significant decrease in the overall positive culture rate of the operating field for all bacteria (P = .001) and specifically for C. acnes (P = .021). The reduction of positive swabs for C. acnes was significant for both the surgeon's gloves (P = .004) and for the subcutaneous tissue (P = .009). C. acnes contamination rate was noted in 26% of patients in the electrocautery group and 13% in the disinfection group after exclusion of the outside scalpel blade sample, which was removed from the scrub nurse's instrument table and therefore no longer used during the procedure.

Conclusion

Disinfection of the subcutaneous tissue reduces the contamination rate of C. acnes by a factor of 2 during open shoulder surgery compared with an approach performed with electrocautery and could limit the contamination of the operating field.
背景:痤疮表皮杆菌(C. acnes)是一种与肩部手术后感染相关的病原体。暴露可发生在手术解剖过程中,并通过外科医生的手套和器械在手术野中扩散。对皮下组织进行消毒已被证明可减少其污染。没有证据表明用电灼术进行解剖会降低传播率。本研究的目的是确定在初次肩部手术中,与电灼解剖相比,皮下组织消毒是否能降低痤疮杆菌的发生率。我们也想比较电切术后手术野的污染率与文献中发现的情况。方法所有符合经三角胸肌入路行首次开肩手术条件的患者前瞻性纳入我们的单盲、双臂随机临床试验。对于每位患者,在标准皮肤准备之前,从手术区域取拭子。消毒组在三角筋膜暴露后皮下用聚维酮碘溶液处理。烧灼组采用电灼法进行皮下组织剥离。在充分暴露肱骨近端后,按照严格的程序从不同位置收集5个拭子进行微生物分析。所有培养物在好氧和厌氧条件下孵育14天。结果2020年2月至2021年7月,210例肩关节患者分为2组(消毒组140例,烧灼组70例)。两组在性别、年龄、体重指数或糖尿病患病率方面均无显著差异。皮下消毒方案导致手术区所有细菌的总体阳性培养率显著降低(P = 0.001),特别是痤疮芽胞杆菌(P = 0.021)。对于外科医生的手套(P = 0.004)和皮下组织(P = 0.009),痤疮杆菌阳性拭子的减少是显著的。电灼组26%的患者和消毒组13%的患者在排除手术刀外刀片样本后发现痤疮污染率,手术刀外刀片从擦洗护士的仪器台上取出,因此在手术过程中不再使用。结论肩关节开放性手术中皮下消毒可使痤疮杆菌的污染率比电灼法降低2倍,并可限制手术野的污染。
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引用次数: 0
Mitochondria dysfunction and increased expression of WNT5A and BNIP3 in tenocytes obtained from patients with tendinopathy 从肌腱病变患者获得的肌腱细胞中线粒体功能障碍和WNT5A和BNIP3表达增加
Q2 Medicine Pub Date : 2025-12-02 DOI: 10.1016/j.jseint.2025.101417
Yusuke Nakagawa MD, PhD , Yuki Okazaki MD, PhD , Camila B. Carballo PT, PhD , Susumu Wada MD, PhD , Daniel Nemirov MD , Elizabeth R. Selvaggio MD , Amir H. Lebaschi MD , Xiang-Hua Deng MD , Miguel Otero PhD , Michelle L. Delco DVM, PhD , Lisa A. Fortier DVM, PhD , Scott A. Rodeo MD

Background

Tendinopathy is a significant source of pain and functional impairment, with contributions from various extrinsic and intrinsic factors. Prior studies have demonstrated the role of mitochondria (MT) dysfunction in a murine model of supraspinatus tendinopathy, with improvement in tendon structure following treatment with the mitochondrial protectant agent Szeto-Schiller-31 (elamipretide). However, there is very little information available on mitochondrial function in human tendinopathy. The purpose of this study is to compare MT function in human tenocytes obtained from pathologic tendons of patients with tendinopathy and normal tendons and to identify potential target genes for the treatment of tendinopathy.

Methods

Samples of degenerative tendons from the upper extremity (biceps tendon [n = 7], rotator cuff [n = 4], and extensor carpi radialis brevis tendon [n = 2]; total n = 13) and normal tendons from the lower extremity (hamstring [n = 4], patellar [n = 3], and quadriceps [n = 2]; total n = 9) were collected during surgeries. Cell viability, ultrastructural morphology (using transmission electron microscopy), differentiation potential (adipogenesis and osteogenesis), MT membrane polarity, production of reactive oxygen species, and gene expression profile (using NanoString and quantitative real-time polymerase chain reaction (qRTPCR)) were analyzed.

Results

Tenocytes from normal tendons exhibited higher colony formation potential (P = .026) and cell viability (P = .017) compared to those from the degenerative group. Transmission electron microscopy revealed degeneration of MT in degenerative tenocytes, with ingestion by phagosomes. The degenerative group showed higher adipogenic potential than the normal group (P = .025). MT membrane potential was significantly decreased in the degenerative group (P < .0001). No gene reached statistical significance when an adjusted P value <.05 was used as the threshold in the NanoString analysis. However, several genes showed upregulation in the degenerative group compared with the normal group (listed in order of smallest P value with log2 fold change, log2FC): IDH2 (P = .0014, log2FC = 0.69), vascular endothelial growth factor (P = .0017, log2FC = 0.63), BNIP3 (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3) (P = .0021, log2FC = 0.70), FGF2 (P = .0026, log2FC = 0.99),WNT5A (Wingless-type MMTV integration site family member 5A) (P = .0027, log2FC = 2.2). WNT5A and BNIP3 upregulation was also confirmed by qRT-PCR.

Conclusion

Our results confirm MT dysfunction in the degenerative group, as reported in previous studies. The upregulation of the WNT5A and BNIP3 expression was confirmed by both Nanostring and qRT-PCR.
背景:肌腱病变是疼痛和功能损害的重要来源,有各种外在和内在因素的影响。先前的研究已经证明了线粒体(MT)功能障碍在冈上肌腱病小鼠模型中的作用,在使用线粒体保护剂Szeto-Schiller-31 (elamipretide)治疗后,肌腱结构得到改善。然而,关于人类肌腱病变的线粒体功能的信息很少。本研究的目的是比较从肌腱病患者的病理肌腱和正常肌腱中获得的人肌腱细胞的MT功能,并确定治疗肌腱病的潜在靶基因。方法术中收集上肢退行性肌腱(二头肌肌腱[n = 7]、肩袖肌腱[n = 4]、桡短腕伸肌腱[n = 2],共n = 13)和下肢正常肌腱(腘绳肌肌腱[n = 4]、髌骨肌腱[n = 3]、股四头肌肌腱[n = 2],共n = 9)。分析细胞活力、超微结构形态(透射电镜)、分化潜能(脂肪生成和成骨)、MT膜极性、活性氧产生和基因表达谱(利用NanoString和定量实时聚合酶链反应(qRTPCR))。结果正常肌腱细胞的集落形成潜能(P = 0.026)和细胞活力(P = 0.017)均高于退行性肌腱组。透射电镜显示MT在退行性细胞中变性,并被吞噬体吞噬。退变组的成脂潜能高于正常组(P = 0.025)。变性组MT膜电位明显降低(P < .0001)。在NanoString分析中,以调整后的P值<; 0.05作为阈值,没有基因达到统计学意义。然而,一些基因显示upregulation退行性组与正常组相比(列出的顺序与log2褶皱变化最小的P值,log2FC): IDH2 (P = .0014 log2FC = 0.69),血管内皮生长因子(P = .0017 log2FC = 0.63), BNIP3 (BCL2 /腺病毒E1B 19 kDa protein-interacting蛋白质3)(P = .0021 log2FC = 0.70), FGF2 (P = .0026 log2FC = 0.99), WNT5A (Wingless-type MMTV集成网站家庭成员5)(P = .0027 log2FC = 2.2)。qRT-PCR也证实了WNT5A和BNIP3的上调。结论我们的研究结果证实了之前研究中报道的退行性MT功能障碍。纳米链和qRT-PCR均证实WNT5A和BNIP3的表达上调。
{"title":"Mitochondria dysfunction and increased expression of WNT5A and BNIP3 in tenocytes obtained from patients with tendinopathy","authors":"Yusuke Nakagawa MD, PhD ,&nbsp;Yuki Okazaki MD, PhD ,&nbsp;Camila B. Carballo PT, PhD ,&nbsp;Susumu Wada MD, PhD ,&nbsp;Daniel Nemirov MD ,&nbsp;Elizabeth R. Selvaggio MD ,&nbsp;Amir H. Lebaschi MD ,&nbsp;Xiang-Hua Deng MD ,&nbsp;Miguel Otero PhD ,&nbsp;Michelle L. Delco DVM, PhD ,&nbsp;Lisa A. Fortier DVM, PhD ,&nbsp;Scott A. Rodeo MD","doi":"10.1016/j.jseint.2025.101417","DOIUrl":"10.1016/j.jseint.2025.101417","url":null,"abstract":"<div><h3>Background</h3><div>Tendinopathy is a significant source of pain and functional impairment, with contributions from various extrinsic and intrinsic factors. Prior studies have demonstrated the role of mitochondria (MT) dysfunction in a murine model of supraspinatus tendinopathy, with improvement in tendon structure following treatment with the mitochondrial protectant agent Szeto-Schiller-31 (elamipretide). However, there is very little information available on mitochondrial function in human tendinopathy. The purpose of this study is to compare MT function in human tenocytes obtained from pathologic tendons of patients with tendinopathy and normal tendons and to identify potential target genes for the treatment of tendinopathy.</div></div><div><h3>Methods</h3><div>Samples of degenerative tendons from the upper extremity (biceps tendon [n = 7], rotator cuff [n = 4], and extensor carpi radialis brevis tendon [n = 2]; total n = 13) and normal tendons from the lower extremity (hamstring [n = 4], patellar [n = 3], and quadriceps [n = 2]; total n = 9) were collected during surgeries. Cell viability, ultrastructural morphology (using transmission electron microscopy), differentiation potential (adipogenesis and osteogenesis), MT membrane polarity, production of reactive oxygen species, and gene expression profile (using NanoString and quantitative real-time polymerase chain reaction (qRTPCR)) were analyzed.</div></div><div><h3>Results</h3><div>Tenocytes from normal tendons exhibited higher colony formation potential (<em>P</em> = .026) and cell viability (<em>P</em> = .017) compared to those from the degenerative group. Transmission electron microscopy revealed degeneration of MT in degenerative tenocytes, with ingestion by phagosomes. The degenerative group showed higher adipogenic potential than the normal group (<em>P</em> = .025). MT membrane potential was significantly decreased in the degenerative group (<em>P</em> &lt; .0001). No gene reached statistical significance when an adjusted <em>P</em> value &lt;.05 was used as the threshold in the NanoString analysis. However, several genes showed upregulation in the degenerative group compared with the normal group (listed in order of smallest <em>P</em> value with log2 fold change, log2FC): IDH2 (<em>P</em> = .0014, log2FC = 0.69), vascular endothelial growth factor (<em>P</em> = .0017, log2FC = 0.63), BNIP3 (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3) (<em>P</em> = .0021, log2FC = 0.70), FGF2 (<em>P</em> = .0026, log2FC = 0.99),WNT5A (Wingless-type MMTV integration site family member 5A) (<em>P</em> = .0027, log2FC = 2.2). WNT5A and BNIP3 upregulation was also confirmed by qRT-PCR.</div></div><div><h3>Conclusion</h3><div>Our results confirm MT dysfunction in the degenerative group, as reported in previous studies. The upregulation of the WNT5A and BNIP3 expression was confirmed by both Nanostring and qRT-PCR.</div></div>","PeriodicalId":34444,"journal":{"name":"JSES International","volume":"10 2","pages":"Article 101417"},"PeriodicalIF":0.0,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk factors for new-onset anxiety and depression after arthroscopic shoulder stabilization surgery 关节镜肩关节稳定手术后新发焦虑和抑郁的危险因素
Q2 Medicine Pub Date : 2025-12-02 DOI: 10.1016/j.jseint.2025.101413
David C. Lutati BS, Jane C. Brennan MS, Andrea H. Johnson MSN, CRNP, Matthew A. Peterman DO, Daniel E. Redziniak MD, Cyrus J. Lashgari MD, Justin J. Turcotte PhD, MBA

Background

Shoulder instability is a common shoulder pathology, especially in young athletes involved in contact sports, sometimes requiring surgical intervention. In this retrospective database study, we aimed to identify the incidence of new-onset anxiety or depression (NOAD) after arthroscopic shoulder stabilization surgery, identify risk factors for the development of NOAD, evaluate the effect of NOAD on postoperative complications, and examine whether psychiatric interventions have a protective effect against adverse outcomes.

Methods

A retrospective analysis of the PearlDiver national database was completed. Included patients had no prior diagnosis of depression/anxiety or prior utilization of antidepressant medication before shoulder stabilization surgery and had at least 1 year of postoperative follow-up. The primary outcome was the development of NOAD within 1 year postoperatively. Multivariate logistic regression was used to assess predictors of NOAD. Postoperative outcomes were compared between patients who did and did not develop NOAD after propensity score matching. A subgroup comparison of outcomes across various NOAD treatments was performed.

Results

Of the 38,388 patients, 1,950 (5.1%) were diagnosed with NOAD within 1 year postoperatively. Increased age (odds ratio [OR]: 0.98, 95% confidence interval [CI]: 0.98-0.98; P < .001), increased Charlson Comorbidity Index score (OR: 1.07, 95% CI: 1.01-1.12; P = .012), female sex (OR: 1.72, 95% CI: 1.56-1.89; P < .001), hypermobility (OR: 2.17, 95% CI: 1.33-3.38; P = .001), headaches/migraines (OR: 1.33, 95% CI: 1.20-1.47; P < .001), obesity (OR: 1.49; 95% CI: 1.31-1.70; P < .001), preoperative opioid use (OR: 3.68, 95% CI: 3.34-4.05; P < .001), tobacco use (OR: 2.25, 95% CI: 1.99-2.53; P < .001), and alcohol disorders (OR: 2.13, 95% CI: 1.70-2.64; P < .001) were all associated with a higher risk of developing NOAD. Postoperatively, the NOAD group had a 9.52 times increased risk of 90-day readmission (P < .001), a 1.58-times increased risk of prolonged opioid use (P < .001) at 1 year, increased total cost ($11,107 ± 12,317 vs. $7,695 ± 8,840; P < .001), and a 1.48-times increased risk of revision at 2 years (P < .001). Patients with NOAD undergoing psychotherapy had lower rates of postoperative opioid use.

Conclusion

The postoperative development of NOAD is an understudied but relatively common complication of arthroscopic shoulder stabilization surgery, occurring in approximately 5% of patients. The current study highlights a variety of risk factors that may be used to identify at-risk patient populations. Further work is needed to identify interventions that can mitigate the adverse outcomes associated with NOAD.
背景:肩部不稳定是一种常见的肩部病理,特别是在从事接触性运动的年轻运动员中,有时需要手术干预。在这项回顾性数据库研究中,我们旨在确定关节镜肩关节稳定手术后新发焦虑或抑郁(NOAD)的发生率,确定NOAD发展的危险因素,评估NOAD对术后并发症的影响,并检查精神干预是否对不良结局有保护作用。方法对PearlDiver国家数据库进行回顾性分析。纳入的患者在肩部稳定手术前没有抑郁/焦虑的诊断,也没有使用过抗抑郁药物,术后随访至少1年。主要观察指标为术后1年内NOAD的发展情况。采用多因素logistic回归评估NOAD的预测因素。在倾向评分匹配后,比较发生和未发生NOAD的患者的术后结果。对不同NOAD治疗的结果进行亚组比较。结果38388例患者中,1950例(5.1%)在术后1年内确诊为NOAD。年龄增加(优势比[OR]: 0.98, 95%可信区间[CI]: 0.98-0.98; P < 001), Charlson共病指数评分增加(OR: 1.07, 95% CI: 1.01-1.12; P = 0.012),女性增加(OR: 1.72, 95% CI: 1.56-1.89; P < 001),活动过度(OR: 2.17, 95% CI: 1.33-3.38; P = 0.001),头痛/偏头痛(OR: 1.33, 95% CI: 1.20-1.47; P < 001),肥胖(OR: 1.49; 95% CI: 1.31-1.70; P < 001),术前阿片类药物使用(OR: 3.68, 95% CI: 3.34-4.05;P < .001)、吸烟(OR: 2.25, 95% CI: 1.99-2.53; P < .001)和酒精障碍(OR: 2.13, 95% CI: 1.70-2.64; P < .001)都与患NOAD的高风险相关。术后,NOAD组90天再入院风险增加9.52倍(P < 0.001), 1年阿片类药物使用时间延长风险增加1.58倍(P < 0.001),总费用增加(11,107±12,317美元对7,695±8,840美元;P < 0.001), 2年翻修风险增加1.48倍(P < 0.001)。接受心理治疗的NOAD患者术后阿片类药物使用率较低。结论NOAD的术后发展是关节镜肩关节稳定手术中一个未被充分研究但相对常见的并发症,发生率约为5%。目前的研究强调了各种可能用于识别高危患者人群的风险因素。需要进一步的工作来确定可以减轻NOAD相关不良后果的干预措施。
{"title":"Risk factors for new-onset anxiety and depression after arthroscopic shoulder stabilization surgery","authors":"David C. Lutati BS,&nbsp;Jane C. Brennan MS,&nbsp;Andrea H. Johnson MSN, CRNP,&nbsp;Matthew A. Peterman DO,&nbsp;Daniel E. Redziniak MD,&nbsp;Cyrus J. Lashgari MD,&nbsp;Justin J. Turcotte PhD, MBA","doi":"10.1016/j.jseint.2025.101413","DOIUrl":"10.1016/j.jseint.2025.101413","url":null,"abstract":"<div><h3>Background</h3><div>Shoulder instability is a common shoulder pathology, especially in young athletes involved in contact sports, sometimes requiring surgical intervention. In this retrospective database study, we aimed to identify the incidence of new-onset anxiety or depression (NOAD) after arthroscopic shoulder stabilization surgery, identify risk factors for the development of NOAD, evaluate the effect of NOAD on postoperative complications, and examine whether psychiatric interventions have a protective effect against adverse outcomes.</div></div><div><h3>Methods</h3><div>A retrospective analysis of the PearlDiver national database was completed. Included patients had no prior diagnosis of depression/anxiety or prior utilization of antidepressant medication before shoulder stabilization surgery and had at least 1 year of postoperative follow-up. The primary outcome was the development of NOAD within 1 year postoperatively. Multivariate logistic regression was used to assess predictors of NOAD. Postoperative outcomes were compared between patients who did and did not develop NOAD after propensity score matching. A subgroup comparison of outcomes across various NOAD treatments was performed.</div></div><div><h3>Results</h3><div>Of the 38,388 patients, 1,950 (5.1%) were diagnosed with NOAD within 1 year postoperatively. Increased age (odds ratio [OR]: 0.98, 95% confidence interval [CI]: 0.98-0.98; <em>P</em> &lt; .001), increased Charlson Comorbidity Index score (OR: 1.07, 95% CI: 1.01-1.12; <em>P</em> = .012), female sex (OR: 1.72, 95% CI: 1.56-1.89; <em>P</em> &lt; .001), hypermobility (OR: 2.17, 95% CI: 1.33-3.38; <em>P</em> = .001), headaches/migraines (OR: 1.33, 95% CI: 1.20-1.47; <em>P</em> &lt; .001), obesity (OR: 1.49; 95% CI: 1.31-1.70; <em>P</em> &lt; .001), preoperative opioid use (OR: 3.68, 95% CI: 3.34-4.05; <em>P</em> &lt; .001), tobacco use (OR: 2.25, 95% CI: 1.99-2.53; <em>P</em> &lt; .001), and alcohol disorders (OR: 2.13, 95% CI: 1.70-2.64; <em>P</em> &lt; .001) were all associated with a higher risk of developing NOAD. Postoperatively, the NOAD group had a 9.52 times increased risk of 90-day readmission (<em>P</em> &lt; .001), a 1.58-times increased risk of prolonged opioid use (<em>P</em> &lt; .001) at 1 year, increased total cost ($11,107 ± 12,317 vs. $7,695 ± 8,840; <em>P</em> &lt; .001), and a 1.48-times increased risk of revision at 2 years (<em>P</em> &lt; .001). Patients with NOAD undergoing psychotherapy had lower rates of postoperative opioid use.</div></div><div><h3>Conclusion</h3><div>The postoperative development of NOAD is an understudied but relatively common complication of arthroscopic shoulder stabilization surgery, occurring in approximately 5% of patients. The current study highlights a variety of risk factors that may be used to identify at-risk patient populations. Further work is needed to identify interventions that can mitigate the adverse outcomes associated with NOAD.</div></div>","PeriodicalId":34444,"journal":{"name":"JSES International","volume":"10 2","pages":"Article 101413"},"PeriodicalIF":0.0,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Longitudinal analysis of rotator cuff repair: joint kinematics and clinical outcomes 肩袖修复的纵向分析:关节运动学和临床结果
Q2 Medicine Pub Date : 2025-12-02 DOI: 10.1016/j.jseint.2025.101421
Sujata Khandare PhD , Rebekah L. Lawrence PT, PhD , Alena Jalics MS , Roger Zauel MS , Vasilios Moutzouros MD , Eric C. Makhni MD, MBA , Stephanie Muh MD , Michael J. Bey PhD

Background

Rotator cuff repair is a common surgical procedure, but postoperative outcomes can be highly variable, and postoperative repair tissue healing remains a significant clinical challenge. Furthermore, the biomechanical effects of rotator cuff repair are not fully understood.

Methods

Twenty-two participants scheduled for arthroscopic rotator cuff repair were evaluated preoperatively and at 3, 12, and 24 months postsurgery. The following data were recorded at each time point: glenohumeral and scapulothoracic kinematics, shoulder strength, and patient-reported measures of pain and function. Postoperative repair integrity was assessed via magnetic resonance imaging at 3 months and 24 months postsurgery.

Results

At 3 months postsurgery, 5 of 20 patients were identified as having a recurrent tear. An additional 4 patients had a recurrent tear at 24 months postsurgery. The center of contact of the humerus on the glenoid gradually shifted superiorly on the glenoid during the 24 month follow-up period (P < .01). There were subtle changes in scapulothoracic upward rotation at 3 months postsurgery compared to presurgery (P ≤ .01), but these differences did not persist at 12 or 24 months postsurgery. Compared to presurgery, there were significant increases in flexion and internal rotation strength at 12 months postsurgery (P < .01) and significant increases in flexion, abduction, external rotation, and internal rotation strength at 24 months postsurgery (P < .01). Patient-reported measures of pain and function improved significantly over the 24 month follow-up period (P < .01).

Conclusion

Surgical rotator cuff repair was associated with decreased pain and improved subjective assessments of function within the first 3 months after surgery, and increased shoulder strength over 12- 24 months postsurgery. The study also found subtle changes over time in glenohumeral joint and scapulothoracic motion.
背景肩袖修复是一种常见的外科手术,但术后结果可能高度可变,术后修复组织愈合仍然是一个重大的临床挑战。此外,肩袖修复的生物力学效应尚未完全了解。方法术前、术后3个月、12个月和24个月对22例关节镜下肩袖修复患者进行评估。在每个时间点记录以下数据:肩关节和肩胛骨的运动学、肩部力量和患者报告的疼痛和功能测量。术后3个月和24个月通过磁共振成像评估修复完整性。结果术后3个月,20例患者中有5例复发性撕裂。另有4例患者在术后24个月出现复发性撕裂。在24个月的随访期间,肱骨在关节盂上的接触中心逐渐向关节盂上移(P < 0.01)。术后3个月与术前相比,肩胛骨上旋有细微的变化(P≤0.01),但这些差异在术后12或24个月没有持续存在。与术前相比,术后12个月屈曲和内旋强度显著增加(P < 0.01),术后24个月屈曲、外展、外旋和内旋强度显著增加(P < 0.01)。患者报告的疼痛和功能测量在24个月的随访期间显著改善(P < 0.01)。结论手术肩袖修复与术后前3个月内疼痛减轻和主观功能评价改善有关,并在术后12- 24个月内增加肩部力量。研究还发现,随着时间的推移,肩胛骨关节和肩胛骨运动也会发生微妙的变化。
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引用次数: 0
Total resection and reconstruction of collateral ligaments in severe elbow stiffness induced by heterotopic ossification: a novel approach and review of the literature 完全切除和重建副韧带治疗异位骨化引起的严重肘关节僵硬:一种新方法和文献综述
Q2 Medicine Pub Date : 2025-12-02 DOI: 10.1016/j.jseint.2025.101418
Mehmet Fatih Güven MD , Muhammed Yusuf Afacan MD, FEBOT, PhD , Erdem Şahin MD , Göker Utku Değer MD

Background

Post-traumatic elbow stiffness poses a complex challenge, often attributed to intrinsic and extrinsic factors. Heterotopic ossification (HO) is a significant extrinsic contributor, leading to contracture and entrapment syndromes. This study explores the pioneering strategy of total resection and reconstruction of the ossified and contracted collateral ligament in managing extensive HO-induced elbow stiffness. Our goal was to show that complete collateral ligament excision and reconstruction result in a wide range of motion and no long-term HO or elbow instability.

Methods

Six patients with severe elbow stiffness underwent HO resection and extensive soft tissue release. Two of them underwent a single fraction of radiotherapy, receiving a dose of 7 gray within the 24 hours preceding the surgery. Five patients with extensive medial HO underwent medial collateral ligament reconstruction using palmaris longus autografts in four of them and tensor fascia lata autograft in one of them, and one patient underwent lateral collateral ligament reconstruction with palmaris longus autograft after lateral collateral ligament sacrifice. Anterior transposition of the ulnar nerve was carried out for all patients to prevent postoperative ulnar nerve symptoms. Evaluations included preoperative and postoperative elbow flexion/extension arcs and Mayo Elbow Performance Score.

Results

The study included six patients with stiff elbows (five males, 1 female), aged 17- 45 years (mean age: 30 years). Injury patterns included three nonvehicle traffic accidents and three trauma-related injuries. The trauma-to-surgery interval ranged from 6 to 288 months, with a mean of 79.17. Three patients required intensive care unit stays before surgery, while the other three did not, suggesting varying causes of HO development. After an average follow-up of 3 years, patients exhibited improved flexion/extension arcs (122.5°) from a mean preoperative 20°. The mean Mayo Elbow Performance Score improved from 21.67 preoperatively to 98.33 postoperatively. None of the patients reported varus or valgus instability.

Conclusion

Our study demonstrates that excision and reconstruction of the ligament with HO can be a viable and reliable solution for elbow joint stiffness, particularly when the wide HO involves collateral ligaments and loosening procedures are deemed insufficient. Our approach proves cost-effectiveness compared to alternatives involving suture anchors or external fixators, with the added advantage of facilitating more flexion and extension postoperatively to preserve the achieved range of motion.
背景创伤后肘关节僵硬是一个复杂的挑战,通常归因于内在和外在因素。异位骨化(HO)是一个重要的外在因素,导致挛缩和夹持综合征。本研究探讨了完全切除和重建骨化和收缩的副韧带的开创性策略,以治疗广泛的ho引起的肘关节僵硬。我们的目的是证明完全的副韧带切除和重建导致大范围的活动,没有长期的HO或肘关节不稳定。方法对6例肘关节严重僵硬患者行HO切除术和广泛软组织松解术。其中两人接受了单一部分放射治疗,在手术前24小时内接受了7格雷的剂量。5例广泛内侧侧HO患者4例行自体掌长肌内侧副韧带重建,1例行自体阔筋膜张肌内侧副韧带重建,1例行外侧副韧带牺牲后自体掌长肌外侧副韧带重建。所有患者均行尺神经前移位以预防术后尺神经症状。评估包括术前和术后肘关节屈伸弧度和Mayo肘关节功能评分。结果本研究纳入6例肘部僵硬患者(男5例,女1例),年龄17 ~ 45岁,平均年龄30岁。伤害类型包括三起非车辆交通事故和三起与创伤有关的伤害。创伤至手术间隔6 ~ 288个月,平均79.17个月。三名患者在手术前需要重症监护病房,而其他三名患者则不需要,这表明HO发展的原因各不相同。平均随访3年后,患者的屈伸弧度(122.5°)较术前平均20°有所改善。Mayo肘关节功能评分从术前的21.67分提高到术后的98.33分。没有患者报告内翻或外翻不稳。结论:我们的研究表明,切除和重建带HO的韧带是解决肘关节僵硬的可行和可靠的方法,特别是当宽HO涉及副韧带和松动手术被认为不够时。与其他包括缝合锚钉或外固定架的方法相比,我们的方法证明了成本效益,并且具有促进术后更多屈曲和伸展以保持已达到的活动范围的额外优势。
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