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Rib construct for severe spinal deformity in young children: a 3-part investigation of biomechanical, animal, and clinical case data 肋骨构造治疗幼儿严重脊柱畸形:生物力学、动物和临床病例数据的三部分调查
IF 2.5 Q3 Medicine Pub Date : 2025-09-01 DOI: 10.1016/j.xnsj.2025.100776
Daniel J. Bonthius MD, PhD , Richard H. Gross MD , Mohammed A. Alshareef MD , Gregory J. Wright PhD , Shuchun Sun PhD , Yongren Wu PhD , Hai Yao PhD

Background

Early-onset spinal deformity (EOSD), occurring before age 10, requires surgical techniques that accommodate spinal growth. Traditional intra-spinal methods like growing rods have high complication rates. The rib construct is an alternative technique that uses rib-based fixation for correcting EOSD. The objective of this study is to evaluate its performance.

Methods

Biomechanical bending and torsional tests on 20 harvested pig spines compared the pull-out and twisting forces between the rib construct and pedicle screw. For the animal study, hyperkyphosis was induced in 6 immature pigs and subsequently corrected using the rib construct; radiographic and histological evaluations assessed the correction outcomes. Retrospective clinical data on 14 patients (8 male, 6 female) treated with the rib construct for severe nonidiopathic spinal deformity were studied including diagnosis, age at index surgery, length of follow-up, T-score bone density, complication rates, procedure time, operative blood loss, and radiographic outcomes.

Results

Biomechanical testing studies demonstrated that the rib construct was less prone to proximal fixation failure and less stiff compared to pedicle screws. Animal model studies demonstrated improvement in spinal alignment in hyperkyphotic pigs instrumented with the rib construct. Finally, clinical study outcomes demonstrated excellent deformity correction with the rib construct and a reduction in serious complications compared to other techniques.

Conclusions

The rib construct effectively corrects spinal deformity through growth modulation while supporting spinal growth and pulmonary development. It substantially reduces the incidence of severe complications commonly associated with EOSD treatments and is particularly beneficial in cases involving hyperkyphosis and/or osteoporosis.
背景早发性脊柱畸形(EOSD)发生在10岁之前,需要适应脊柱生长的手术技术。传统的脊髓内方法如生长棒有很高的并发症发生率。肋骨结构是一种替代技术,使用肋骨为基础的固定来纠正EOSD。本研究的目的是评估其性能。方法对20根收获的猪棘进行生物力学弯曲和扭转试验,比较肋骨结构和椎弓根螺钉的拉出力和扭转力。在动物实验中,6只未成熟的猪被诱导后凸过度,随后使用肋骨结构进行矫正;影像学和组织学评估矫正效果。回顾性研究了14例(男8例,女6例)采用肋骨结构治疗严重非特发性脊柱畸形的临床资料,包括诊断、指数手术年龄、随访时间、t评分骨密度、并发症发生率、手术时间、手术出血量和影像学结果。结果生物力学试验表明,与椎弓根螺钉相比,该肋骨结构更不容易发生近端固定失败,僵硬程度也更低。动物模型研究表明,在脊柱后凸猪仪器与肋骨结构改善脊柱对齐。最后,临床研究结果表明,与其他技术相比,肋骨结构具有良好的畸形矫正效果,并且减少了严重并发症。结论肋骨结构通过调节生长有效纠正脊柱畸形,同时支持脊柱生长和肺发育。它大大降低了通常与EOSD治疗相关的严重并发症的发生率,对涉及脊柱后凸和/或骨质疏松症的病例尤其有益。
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引用次数: 0
Implementation of artificial intelligence (AI) in ASD treatment1 人工智能(AI)在ASD治疗中的应用
IF 2.5 Q3 Medicine Pub Date : 2025-08-27 DOI: 10.1016/j.xnsj.2025.100787
Kyriakos D. Chatzis BS, Peter Tretiakov BS, Peter G. Passias MD

Background

Adult spinal deformity (ASD) surgery remains one of the most complex and complication-prone areas of spine care, with significant variability in outcomes and high complication rates. Recent advances in artificial intelligence (AI) have shown to be promising tools to address these challenges by improving planning, prediction, and personalization. This narrative review explores the role of AI across the surgical workflow for ASD, from preoperative decision-making to intraoperative execution and postoperative care.

Methods

We conducted a comprehensive narrative review of current literature and technologies related to AI in ASD surgery. Focus areas included evidence synthesis, predictive analytics, automated radiographic assessment, intraoperative navigation, patient-specific implants, and digital patient engagement. We also present a representative case example of AI-assisted deformity correction to illustrate practical clinical application.

Results

AI tools have demonstrated strong potential in improving accuracy and efficiency across various domains. Machine learning algorithms outperform traditional statistical models in predicting complications, length of stay, and functional outcomes. Automated radiographic platforms reliably reproduce spinal alignment measurements and support surgical planning. Personalized instrumentation has been associated with improved alignment fidelity. Lastly, Intraoperative AR/VR platforms and AI-enhanced robotics are helping to standardize execution and reduce variability.

Conclusions

AI is redefining the landscape of ASD surgery through its ability to enhance decision-making, reduce variability, and enable personalized, data-driven care. While widespread adoption requires ongoing validation and integration, current evidence supports the clinical utility of AI-assisted strategies in improving alignment outcomes and surgical safety. This review highlights the growing potential of AI to serve as a cornerstone of precision spine surgery.
成人脊柱畸形(ASD)手术仍然是脊柱护理中最复杂和最容易发生并发症的领域之一,其结果具有显著的可变性和高并发症发生率。人工智能(AI)的最新进展表明,通过改进规划、预测和个性化,人工智能是解决这些挑战的有希望的工具。这篇叙述性综述探讨了人工智能在ASD手术流程中的作用,从术前决策到术中执行和术后护理。方法对人工智能在ASD手术中的应用现状及相关技术进行综述。重点领域包括证据合成、预测分析、自动放射评估、术中导航、患者特定植入物和数字化患者参与。我们也提出一个人工智能辅助畸形矫正的典型案例来说明实际的临床应用。结果这些工具在提高不同领域的准确性和效率方面显示出强大的潜力。机器学习算法在预测并发症、住院时间和功能结果方面优于传统的统计模型。自动化放射平台可靠地再现脊柱对齐测量并支持手术计划。个性化仪器与提高对准保真度有关。最后,术中AR/VR平台和人工智能增强的机器人技术有助于标准化执行并减少可变性。ai正在通过其增强决策、减少可变性和实现个性化、数据驱动的护理的能力,重新定义自闭症谱系障碍手术的前景。虽然广泛采用需要持续的验证和整合,但目前的证据支持人工智能辅助策略在改善对齐结果和手术安全性方面的临床应用。这篇综述强调了人工智能作为精确脊柱手术基石的日益增长的潜力。
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引用次数: 0
Identifying patients at risk for a facility discharge following elective one or two level lumbar fusion 确定选择性一节段或二节段腰椎融合术后有出院风险的患者
IF 2.5 Q3 Medicine Pub Date : 2025-08-24 DOI: 10.1016/j.xnsj.2025.100786
Matthew J. Solomito PhD , Heeren Makanji MD , Jesse Eisler MD

Background

Spine procedures are becoming increasingly common and costly in the United States, thus managing fiscal responsibility with surgical outcomes is increasingly important. Reducing facility discharges following a lumbar fusion would not only reduce complications but could provide significant cost savings. Therefore, the purpose of this study is to identify both clinical factors (i.e. demographics, medical history factors) and patient reported outcome scores that were associated with an increased risk of a facility-based discharge following an elective 1 or 2 level lumbar fusion.

Methods

A total of 513 patients that underwent a 1- or 2-level lumbar fusion between June 2021 and June 2023 were included in this retrospective study. All patients completed their preoperative PROs and completed their medical history and physical prior to surgery. Using logistic regressions, independent variables associated with postoperative discharge to a skilled nursing facility were identified. Subsequent receiver operator curve analysis helped determine cut point values associated with a facility discharge.

Results

A total of 41 patients (7.9%) were discharged to a facility. Regression analysis identified 6 factors associated with a facility discharge. Three factors were related to clinical outcomes while the other 3 factors were obtained from patient reported outcomes measures. More specifically, PROMIS-10 Global physical (OR:0.17,95% CI 0.04–0.62, AUC:0.701) and mental health (OR:0.89,95% CI 0.83–0.95, AUC:0.813) T-scores below 40, and RAPT scores below 9 (OR:0.60,95% CI 0.48–0.74, AUC:0.814) were associated with facility-based discharges.

Conclusions

Patient reported outcomes measures provide significant discriminatory ability in combination with standard clinical metrics to identify patients at risk for a facility discharge following elective lumbar fusions. The results suggested that patient reported information concerning preoperative mobility, mental wellbeing, and support at home were more discriminatory than clinical metrics.
背景:脊柱手术在美国变得越来越普遍和昂贵,因此管理手术结果的财政责任变得越来越重要。减少腰椎融合术后的设施出院不仅可以减少并发症,而且可以显著节省费用。因此,本研究的目的是确定临床因素(即人口统计学、病史因素)和患者报告的结果评分,这些因素与择期1节段或2节段腰椎融合术后住院风险增加有关。方法本回顾性研究纳入了2021年6月至2023年6月期间接受1节段或2节段腰椎融合术的513例患者。所有患者均完成术前pro检查,并在手术前完成病史和体格检查。使用逻辑回归,确定了与术后出院到熟练护理机构相关的独立变量。随后的接收操作曲线分析有助于确定与设施排放相关的切点值。结果41例(7.9%)出院。回归分析确定了与设施排放相关的6个因素。其中3个因素与临床结果相关,另外3个因素来自患者报告的结果测量。更具体地说,承诺-10整体身体(OR:0.17,95% CI 0.04-0.62, AUC:0.701)和心理健康(OR:0.89,95% CI 0.83-0.95, AUC:0.813) t评分低于40,RAPT评分低于9 (OR:0.60,95% CI 0.48-0.74, AUC:0.814)与设施基础出院相关。结论:患者报告的结果指标与标准临床指标相结合,提供了显著的区分能力,以识别择期腰椎融合术后有出院风险的患者。结果表明,患者报告的有关术前活动能力、心理健康和家庭支持的信息比临床指标更具歧视性。
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引用次数: 0
The impact of metabolic syndrome on one-year patient-reported outcomes after lumbar fusion surgery 代谢综合征对腰椎融合术后患者报告的一年预后的影响
IF 2.5 Q3 Medicine Pub Date : 2025-08-21 DOI: 10.1016/j.xnsj.2025.100785
Jack Parker BS, Jane C. Brennan MS, Andrea H. Johnson MSN, CRNP, Chad M. Patton MD, MS, Justin J. Turcotte PhD, MBA

Background

The prevalence of Metabolic Syndrome (MetS) is increasing and negatively impacts a variety of surgeries. In lumbar fusions, MetS is associated with an increased risk of complications, however no studies have focused on patient-reported outcome measures (PROMs). The aim of this study was to explore the relationship between MetS and 1-year PROMs in lumbar fusion patients using the Patient-Reported Outcomes Measurement Information System (PROMIS).

Methods

Retrospective review of 212 patients who underwent 1- to 3-level lumbar fusion for degenerative pathologies between March 2021 and December 2023 from a single institution was performed. Patients were categorized based on the presence of MetS, defined as having 3 or more qualifying metabolic conditions, and assessed using PROMIS surveys (Physical Function [PF], Mental Health, and Pain Interference) preoperatively and at 1-year postoperatively. Univariate and multivariate analyses were performed to evaluate the impact of MetS on PROMIS improvement.

Results

Patients with MetS (n=64, 30.2%) had a longer length of stay, were more likely to be discharged to a skilled nursing facility, and experienced higher rates of 1-year complications (37.5vs. 20.9%, p=.016). After risk-adjustment, MetS patients had lower odds of achieving clinically significant improvement in PROMIS-PF (OR: 0.46, p=.020). In obese patients, the presence of MetS was associated with less improvement (β: -3.22, p=.049) and lower odds of clinically significant improvement in PROMIS-PF (OR: 0.34, p=.017). No significant associations between MetS and mental health or pain interference scores were observed in the overall population or obese patients.

Conclusions

MetS negatively impacts outcomes following lumbar fusion, and this difference in outcomes is not solely explained by obesity. Patients should be encouraged to modify their lifestyle to reduce the adverse effects of MetS on outcomes, and surgeons should consider the impact of MetS on outcomes following lumbar fusion and communicate these expectations with patients.
代谢综合征(MetS)的患病率正在增加,并对各种手术产生负面影响。在腰椎融合术中,MetS与并发症的风险增加有关,但是没有研究关注患者报告的结果测量(PROMs)。本研究的目的是利用患者报告的结果测量信息系统(PROMIS)探讨腰椎融合术患者的MetS与1年PROMs之间的关系。方法回顾性分析2021年3月至2023年12月在同一医院接受1至3节段腰椎融合术治疗退行性病变的212例患者。根据MetS的存在对患者进行分类,定义为具有3种或更多符合条件的代谢条件,并在术前和术后1年使用PROMIS调查(身体功能[PF],心理健康和疼痛干扰)进行评估。进行单因素和多因素分析来评估MetS对PROMIS改善的影响。结果met患者(n=64, 30.2%)的住院时间更长,更有可能出院到专业护理机构,1年并发症发生率更高(37.5vs. 37.5)。20.9%, p = .016)。风险调整后,MetS患者在promise - pf中获得临床显著改善的几率较低(OR: 0.46, p= 0.020)。在肥胖患者中,MetS的存在与较低的改善相关(β: -3.22, p= 0.049),并且promise - pf临床显著改善的几率较低(OR: 0.34, p= 0.017)。在总体人群或肥胖患者中,没有观察到MetS与心理健康或疼痛干扰评分之间的显著关联。结论:smets对腰椎融合术后的预后有负面影响,这种结果的差异并不能完全用肥胖来解释。应鼓励患者改变生活方式以减少MetS对预后的不良影响,外科医生应考虑MetS对腰椎融合术后预后的影响,并与患者沟通这些期望。
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引用次数: 0
Identifying preoperative radiographic metrics to guide surgical selection in lumbar spondylolisthesis and stenosis 确定术前影像学指标以指导腰椎滑脱和腰椎狭窄的手术选择
IF 2.5 Q3 Medicine Pub Date : 2025-08-21 DOI: 10.1016/j.xnsj.2025.100784
John A. Hipp PhD , Bradford L. Currier MD , Trevor F. Grieco PhD , Job L.C. Van Susante MD

Background Context

“Instability” often drives the decision to add fusion to decompression, yet most instability criteria lean solely on sagittal translation and have never been rigorously validated. The potential of a metric for sagittal plane translation to help decide whether fusion should be added to decompression surgery for symptomatic lumbar stenosis with spondylolisthesis was recently reported. Building on imaging and outcomes from that study, we investigated whether other motion metrics may help to predict postoperative disability and patient‐reported outcomes in lumbar stenosis with spondylolisthesis.

Methods

Radiographic metrics were retrospectively calculated from the prospectively collected flexion-extension radiographs of 61 patients with lumbar spinal stenosis and spondylolisthesis. A threshold-limit graphical approach was used to identify metrics and thresholds predictive of the Oswestry Disability Index, leg/buttock pain, and patient satisfaction. Outcomes were compared across groups defined by these threshold levels using statistical analysis.

Results

Decompression-only surgery was associated with poorer outcomes in patients exhibiting vertical instability or significant spondylolisthesis changes between flexion and extension. Conversely, decompression-plus-fusion surgery yielded worse outcomes in cases without substantial dynamic spondylolisthesis.

Conclusions

A broader definition of spinal instability may be needed when deciding whether to include fusion in treating lumbar stenosis with spondylolisthesis. Preoperative vertical instability and dynamic slip may be important in addition to translational instability. Larger prospective studies are warranted, but these metrics could help guide the decision on whether fusion is necessary and likely to improve outcomes for a common spinal disorder.
背景:“不稳定性”常常促使我们决定在减压的同时增加融合,然而大多数不稳定性标准仅仅依赖于矢状面平移,从未得到严格的验证。最近有报道称,矢状面平移指标的潜力有助于决定是否应在症状性腰椎管狭窄伴腰椎滑脱的减压手术中加入融合手术。基于该研究的影像学和结果,我们研究了其他运动指标是否有助于预测腰椎管狭窄伴腰椎滑脱的术后残疾和患者报告的结果。方法回顾性计算61例腰椎管狭窄伴腰椎滑脱患者的屈伸x线片放射学指标。阈值-阈值图解法用于确定预测Oswestry残疾指数、腿部/臀部疼痛和患者满意度的指标和阈值。通过统计分析比较各组间的结果,这些结果由这些阈值水平定义。结果仅减压手术与表现出垂直不稳定或屈伸之间明显的脊柱滑脱变化的患者预后较差相关。相反,减压融合手术在没有明显动态脊柱滑脱的情况下产生更差的结果。结论在决定腰椎管狭窄伴椎体滑脱是否纳入融合术时,需要对脊柱不稳定有更广泛的定义。除了平移不稳定外,术前垂直不稳定和动态滑动也可能很重要。更大规模的前瞻性研究是必要的,但这些指标可以帮助指导决定是否需要融合,并可能改善常见脊柱疾病的预后。
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引用次数: 0
Ligamentum flavum: changes in vascular density, physical and histopathobiochemical properties in lumbar spine based on anatomical localization, spinal segment levels, and presence of lumbar spinal stenosis 黄韧带:基于解剖定位、脊柱节段水平和腰椎管狭窄存在的腰椎血管密度、物理和组织病理生化特性的变化
IF 2.5 Q3 Medicine Pub Date : 2025-08-10 DOI: 10.1016/j.xnsj.2025.100782
Jakub Jezek MD, PhD , Josef Sepitka MS, PhD , Petr Kujal MD, PhD , Petr Waldauf MD, PhD , Jan Svec MD , Vojtech Cerny MS , Filip Samal MD, PhD , Jiri Skala-Rosenbaum MD, PhD

Background

Hypertrophy of the ligamentum flavum (LF) contributes significantly to the development of lumbar spinal stenosis (LSS), a serious and often disabling disease predominantly affecting the aging population. Histologic changes in the ligament and the tissue mediators that drive these alterations have been described, but their spatial distribution within the ligament remains unclear. Understanding these changes may enable future interventions to slow ligament degeneration and disease progression. To date, no study has comprehensively described the distribution of pathological changes within individual ligaments.

Methods

This study combined histopathobiochemical analysis and micromechanical mapping of healthy and degenerated human LF specimens obtained perioperatively from 57 patients undergoing lumbar spine surgery (38 with LSS and 19 controls). Ligament samples were analyzed histologically for vascular density, presence of inflammatory infiltrates, and chondroid metaplasia using morphometric software and immunohistochemical staining. Mechanical properties, including stiffness (Young’s modulus) and contact pressure, were measured via nanoindentation using the Hysitron BioSoft In-Situ Indenter system. Samples were spatially mapped across 9 anatomical zones of the LF to investigate regional variation. Statistical analyses compared these parameters between spinal segments (L3/4, L4/5, L5/S1), between LSS and control groups, and evaluated age-related trends.

Results

The central region of the LF exhibited significantly higher vascularity and stiffness compared to peripheral regions. Areas showing chondroid metaplasia and inflammation demonstrated increased vascularization, characteristic of LSS pathology. Although vascular density and mechanical stiffness were elevated in LSS patients versus controls, these differences did not reach statistical significance. Age-related trends differed between groups: stiffness increased with age in controls but decreased in LSS patients.

Conclusions

The greatest changes in vascularization and stiffness occur in the central region of ligamentum flavum. Understanding these localized alterations may support future development of targeted therapies to slow or prevent disease progression.
背景:黄韧带(LF)肥大是腰椎管狭窄症(LSS)发展的重要因素,这是一种严重且常致残的疾病,主要影响老年人。已经描述了韧带的组织学改变和驱动这些改变的组织介质,但它们在韧带内的空间分布尚不清楚。了解这些变化可能使未来的干预措施能够减缓韧带变性和疾病进展。迄今为止,还没有研究全面描述单个韧带内病理变化的分布。方法对57例腰椎手术患者(38例腰椎失稳组,19例对照组)围手术期获得的健康和退变的人LF标本进行组织病理生化分析和显微力学制图。使用形态测量软件和免疫组织化学染色对韧带样本进行血管密度、炎症浸润和软骨样化生的组织学分析。机械性能,包括刚度(杨氏模量)和接触压力,使用hyysitron BioSoft原位压头系统通过纳米压痕进行测量。样本在空间上绘制了LF的9个解剖区,以研究区域差异。统计学分析比较了LSS组和对照组之间(L3/4、L4/5、L5/S1)、LSS组和对照组之间的这些参数,并评估了年龄相关趋势。结果与外周区域相比,LF的中心区域表现出明显更高的血管密度和僵硬度。显示软骨样化生和炎症的区域显示血管化增加,这是LSS病理的特征。尽管与对照组相比,LSS患者的血管密度和机械刚度升高,但这些差异没有达到统计学意义。与年龄相关的趋势在两组之间有所不同:对照组的僵硬度随着年龄的增长而增加,而LSS患者的僵硬度则随着年龄的增长而下降。结论黄韧带中部的血管化和僵硬程度变化最大。了解这些局部改变可能有助于未来开发靶向治疗,以减缓或预防疾病进展。
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引用次数: 0
Comparative analysis of acute postoperative pain and opioid use between lateral transpsoas, anterior, and transforaminal lumbar interbody fusions 侧转腰肌、前路和经椎间孔腰椎椎间融合术后急性疼痛和阿片类药物使用的比较分析
IF 2.5 Q3 Medicine Pub Date : 2025-08-08 DOI: 10.1016/j.xnsj.2025.100781
Ekrem M. Ayhan BS , Thomas Giannasca BS , Jake Laverdiere BS , Laura Sanzari MS , Gina Panek BS , Aris Yannopoulos MD

Background

The lateral transpsoas lumbar interbody fusion is associated with transient postoperative anterior thigh and inguinal dysesthesias and hip flexor weakness from manipulation of the psoas and interposed lumbar plexus. However, it remains unclear whether this translates to higher pain scores and opioid requirements.

Methods

Patients who had undergone one- or two-level extreme/direct (XLIF/DLIF), anterior (ALIF), or transforaminal lumbar interbody fusion (TLIF) between January 2018 and December 2023 for degenerative spinal pathology were included. All cases were further classified as standalone or pedicle screw-fixated, and pedicle screw-fixated was included as a covariate. Outcomes were assessed using multivariable linear or binary logistic regression and included length of stay (LOS), inpatient daily maximum pain scores, inpatient morphine-equivalent daily dosage, and total inpatient morphine milligram equivalents, 30- and 90-day complications, emergency department visits, return to operating room, and readmission, and 90-day and 1-year Oswestry Disability Index (ODI) and EuroQuol-5 Dimension (EQ5D).

Results

A total of 936 patients were assessed, including 90 (9.6%) XLIF/DLIFs, 587 (62.7%) TLIFs, and 259 (27.6%) ALIFs. Pedicle screw fixation differed significantly between approaches (TLIF: 100%, ALIF: 51.0%, XLIF/DLIF: 51.1%; p<.001). The XLIF/DLIF approach had the shortest operative time compared to ALIF and TLIF (p<.003). Furthermore, XLIF/DLIF approach was associated with lower 90-day ODI than TLIF (β=–21.185; p=.002) and ALIF (β=–9.275; p=.043), higher 90-day EQ5D than TLIF (β=+27.389; p<.001) and ALIF (β=+13.897; p=.001), higher morphine-equivalent daily dosage than TLIF (β=+29.115; p<.001) and ALIF (β=+11.959; p=.006), and shorter LOS than TLIF (β=–45.500 hours; p=.014) and ALIF (β=–24.447 hours; p=.049). No significant differences were observed in maximum pain scores, total inpatient morphine milligram equivalents, complications, readmissions, or return to operating room.

Conclusions

Despite a shorter operative time, shorter LOS, and better 90-day ODI and EQ5D, the lateral transpsoas lumbar interbody fusion is associated with higher postoperative inpatient opioid consumption than TLIF and ALIF.

Level of Evidence

III
背景:外侧经腰肌腰椎椎体间融合术与术后短暂的大腿前和腹股沟前感觉障碍和臀屈肌无力有关,这是由腰肌和腰丛的操作引起的。然而,尚不清楚这是否会导致更高的疼痛评分和阿片类药物需求。方法纳入2018年1月至2023年12月期间因退行性脊柱病理接受过一级或二级极端/直接(XLIF/DLIF)、前路(ALIF)或经椎间孔腰椎椎体间融合术(TLIF)的患者。所有病例进一步分类为独立或椎弓根螺钉固定,并将椎弓根螺钉固定作为协变量。结果采用多变量线性或二元logistic回归进行评估,包括住院时间(LOS)、住院患者每日最大疼痛评分、住院患者吗啡当量日剂量和总住院吗啡毫克当量、30天和90天并发症、急诊就诊、返回手术室和再入院,以及90天和1年的Oswestry残疾指数(ODI)和EuroQuol-5维度(EQ5D)。结果共纳入936例患者,其中XLIF/DLIFs 90例(9.6%),TLIFs 587例(62.7%),ALIFs 259例(27.6%)。不同入路间椎弓根螺钉固定差异显著(TLIF: 100%, ALIF: 51.0%, XLIF/DLIF: 51.1%; p<.001)。与ALIF和TLIF相比,XLIF/DLIF入路手术时间最短(p<.003)。此外,XLIF/DLIF方法的90天ODI低于TLIF (β= -21.185; p= 0.002)和ALIF (β= -9.275; p= 0.043), 90天EQ5D高于TLIF (β=+27.389; p<.001)和ALIF (β=+13.897; p=.001),吗啡当量日剂量高于TLIF (β=+29.115; p<.001)和ALIF (β=+11.959; p= 0.006), LOS低于TLIF (β= -45.500小时;p= 0.014)和ALIF (β= -24.447小时;p= 0.049)。在最大疼痛评分、总住院吗啡毫克当量、并发症、再入院或返回手术室方面没有观察到显著差异。结论:与TLIF和ALIF相比,外侧经腰肌椎体间融合术手术时间较短,LOS较短,90天ODI和EQ5D较好,但术后住院阿片类药物消耗较高。证据水平ⅱ
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引用次数: 0
Corrigendum to ``P72. Change of spinal cord alignment within one week after cervical laminoplasty'' [North American Spine Society Journal (NASSJ) 18S (2024) 100476] P72的勘误。颈椎椎板成形术后一周内脊髓对线的改变[北美脊柱学会杂志(NASSJ) 18S (2024) 100476]
IF 2.5 Q3 Medicine Pub Date : 2025-08-06 DOI: 10.1016/j.xnsj.2025.100772
Tatsuya Shibata MD , Yoshikuni Kida MD, PhD , Jun Tanaka MD, PhD , Hideki Ota MD , Yohei Iguchi MD , Teruaki Shiokawa MD , Kyoichi Sanada MD , Shusuke Hagihara MD , Sota Sasaki MD , Akitaka Yoshimura MD , Takuaki Yamamoto MD, PhD
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引用次数: 0
The kiva system versus balloon kyphoplasty for vertebral compression fracture: a meta-analysis of randomized control trials kiva系统与球囊后凸成形术治疗椎体压缩性骨折:随机对照试验的荟萃分析
IF 2.5 Q3 Medicine Pub Date : 2025-08-06 DOI: 10.1016/j.xnsj.2025.100778
Humaid Al Farii MD, Nikhil Gattu MD, Caleb M. Yeung MD, Christopher A. Alvarez-Breckenridge MD, Robert Y. North MD, Claudio E. Tatsui MD, Laurence D. Rhines MD, Valerae O. Lewis MD, Justin E. Bird, Shalin S. Patel

Background

Vertebral compression fractures (VCFs) are the most common type of vertebral body fracture. The Kiva VCF Treatment System is a relatively novel technique to manage VCFs. The aim of this study was to compare the efficacy of Kiva versus standard Balloon Kyphoplasty (BK) through evaluation of published randomized controlled trials (RCTs).

Methods

This study was performed following the guidelines for PRISMA. We performed a systematic literature search using PubMed and MEDLINE in June 2023. The search keywords were “Kiva” and “Kyphoplasty” which yielded a total of 112 articles. Outcome measures included pain, measured through the Visual Analogue Scale (VAS) and Oswestry Disability Index (ODI), and cement leakage rates.

Results

Three RCTs were included in this meta-analysis. A total of 468 patients (Kiva=232 patients and BK=236 patients) and 694 fractures (351 treated with Kiva and 343 treated with BK) were included after fulfilling the inclusion criteria. The VAS score in both the Kiva and BK group improved significantly. There was no difference in VAS improvement between the 2 groups (p-value=.84). Of the 694 fractures that were treated procedurally, the Kiva system had significantly less cement leakage than BK (95% CI [-0.89, -0.22], p-value=.00). However, and collectively out of those who had cement leakage, there was only 2 patients (2.1%) developed adverse events of acute paraplegia required reoperation.

Conclusions

This meta-analysis demonstrates that the Kiva system and balloon kyphoplasty are both strong treatment options for the purpose of reducing pain associated with VCFs, whether osteoporotic or metastatic in etiology. However, Kiva system was favorable over balloon kyphoplasty in terms of rates of cement leakage.
椎体压缩性骨折是最常见的椎体骨折类型。Kiva VCF治疗系统是一种相对新颖的VCF治疗技术。本研究的目的是通过评价已发表的随机对照试验(rct),比较Kiva与标准球囊后凸成形术(BK)的疗效。方法本研究按照PRISMA指南进行。我们于2023年6月使用PubMed和MEDLINE进行了系统的文献检索。搜索关键词是“Kiva”和“Kyphoplasty”,总共产生了112篇文章。结果测量包括疼痛,通过视觉模拟量表(VAS)和Oswestry残疾指数(ODI)测量,以及水泥渗漏率。结果本meta分析纳入3项随机对照试验。符合纳入标准共纳入468例患者(Kiva=232例,BK=236例)和694例骨折(Kiva治疗351例,BK治疗343例)。Kiva组和BK组VAS评分均有明显改善。两组间VAS改善无差异(p值= 0.84)。在694例经手术治疗的骨折中,Kiva系统的水泥渗漏明显少于BK (95% CI [-0.89, -0.22], p值= 0.00)。然而,在所有发生水泥渗漏的患者中,只有2例(2.1%)出现急性截瘫的不良事件,需要再次手术。该meta分析表明,Kiva系统和球囊后凸成形术都是减轻vcf相关疼痛的有力治疗选择,无论其病因是骨质疏松性还是转移性。然而,就水泥渗漏率而言,Kiva系统优于球囊后凸成形术。
{"title":"The kiva system versus balloon kyphoplasty for vertebral compression fracture: a meta-analysis of randomized control trials","authors":"Humaid Al Farii MD,&nbsp;Nikhil Gattu MD,&nbsp;Caleb M. Yeung MD,&nbsp;Christopher A. Alvarez-Breckenridge MD,&nbsp;Robert Y. North MD,&nbsp;Claudio E. Tatsui MD,&nbsp;Laurence D. Rhines MD,&nbsp;Valerae O. Lewis MD,&nbsp;Justin E. Bird,&nbsp;Shalin S. Patel","doi":"10.1016/j.xnsj.2025.100778","DOIUrl":"10.1016/j.xnsj.2025.100778","url":null,"abstract":"<div><h3>Background</h3><div>Vertebral compression fractures (VCFs) are the most common type of vertebral body fracture. The Kiva VCF Treatment System is a relatively novel technique to manage VCFs. The aim of this study was to compare the efficacy of Kiva versus standard Balloon Kyphoplasty (BK) through evaluation of published randomized controlled trials (RCTs).</div></div><div><h3>Methods</h3><div>This study was performed following the guidelines for PRISMA. We performed a systematic literature search using PubMed and MEDLINE in June 2023. The search keywords were “Kiva” and “Kyphoplasty” which yielded a total of 112 articles. Outcome measures included pain, measured through the Visual Analogue Scale (VAS) and Oswestry Disability Index (ODI), and cement leakage rates.</div></div><div><h3>Results</h3><div>Three RCTs were included in this meta-analysis. A total of 468 patients (Kiva=232 patients and BK=236 patients) and 694 fractures (351 treated with Kiva and 343 treated with BK) were included after fulfilling the inclusion criteria. The VAS score in both the Kiva and BK group improved significantly. There was no difference in VAS improvement between the 2 groups (p-value=.84). Of the 694 fractures that were treated procedurally, the Kiva system had significantly less cement leakage than BK (95% CI [-0.89, -0.22], p-value=.00). However, and collectively out of those who had cement leakage, there was only 2 patients (2.1%) developed adverse events of acute paraplegia required reoperation.</div></div><div><h3>Conclusions</h3><div>This meta-analysis demonstrates that the Kiva system and balloon kyphoplasty are both strong treatment options for the purpose of reducing pain associated with VCFs, whether osteoporotic or metastatic in etiology. However, Kiva system was favorable over balloon kyphoplasty in terms of rates of cement leakage.</div></div>","PeriodicalId":34622,"journal":{"name":"North American Spine Society Journal","volume":"24 ","pages":"Article 100778"},"PeriodicalIF":2.5,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145046902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The future of intraoperative neuromonitoring (IONM) in spinal surgery1 脊柱外科术中神经监测(IONM)的应用前景
IF 2.5 Q3 Medicine Pub Date : 2025-08-05 DOI: 10.1016/j.xnsj.2025.100777
W. Bryan Wilent PhD, DABNM , Marcia-Ruth Ndege BS, CNIM , Adam Doan DC, DABNM

Preface

On behalf of the NASS section on intraoperative neuromonitoring (IONM), we present a narrative perspective exploring the future of IONM in spine surgery in the US, drawing on current evidence and future projections.

Present state

IONM is used during hundreds of thousands of spinal procedures each year to enhance patient safety via real-time neurodiagnostic feedback. The most common service model is an in-room technologist and a remote supervising professional who interprets the neurophysiological data. The primary goal of IONM is to: (1) detect significant signal changes from baseline, (2) identify the cause—whether technical, positional, anesthetic, or iatrogenic, and (3) pinpoint the site of injury. This diagnostic process is time-sensitive, complex, and dependent on both the signal pattern change and patient and procedural factors that are dynamically variable.

Future: integrating and advancing technology

Artificial intelligence (AI) and machine learning (ML) hold promise to enhance the accuracy in detecting and interpreting signal changes for IONM clinicians and be integrated into surgeon-directed software platforms. However, widespread AI/ML adoption depends on the availability of large, validated IONM datasets—currently hindered by practice variation, inconsistent perioperative documentation, and unharmonized IONM, anesthetic, surgical, and patient medical records.

Future: maturation in Profession

IONM can improve in the consistency in which optimal IONM is delivered, how IONM is utilized with evidence-based planning for alerts, and the collection of harmonized and complete signal and clinical records. Most publications have focused on the diagnostic accuracy of IONM in predicting deficits, but more emphasis is needed on demonstrating the therapeutic impact of interventions to alerts and their role in preventing new deficits.
我们代表NASS术中神经监测(IONM)部分,根据目前的证据和未来的预测,提出一个叙事视角,探讨IONM在美国脊柱外科中的未来。每年,通过实时神经诊断反馈,在数十万例脊柱手术中使用Present stateIONM来提高患者的安全性。最常见的服务模式是一名室内技术人员和一名解释神经生理学数据的远程监督专业人员。IONM的主要目标是:(1)检测基线的显著信号变化,(2)确定原因——无论是技术、体位、麻醉还是医源性,以及(3)精确定位损伤部位。这个诊断过程是时间敏感的,复杂的,并且依赖于信号模式的变化和患者和程序因素是动态变化的。未来:整合和推进技术人工智能(AI)和机器学习(ML)有望提高IONM临床医生检测和解释信号变化的准确性,并集成到外科指导的软件平台中。然而,人工智能/机器学习的广泛采用取决于大型、经过验证的IONM数据集的可用性——目前受到实践差异、不一致的围手术期文件和不协调的IONM、麻醉、手术和患者医疗记录的阻碍。未来:ProfessionIONM的成熟可以提高最佳IONM交付的一致性,IONM如何与基于证据的警报计划一起使用,以及协调完整的信号和临床记录的收集。大多数出版物都关注IONM在预测缺陷方面的诊断准确性,但需要更多地强调证明干预措施对警报的治疗影响及其在预防新缺陷中的作用。
{"title":"The future of intraoperative neuromonitoring (IONM) in spinal surgery1","authors":"W. Bryan Wilent PhD, DABNM ,&nbsp;Marcia-Ruth Ndege BS, CNIM ,&nbsp;Adam Doan DC, DABNM","doi":"10.1016/j.xnsj.2025.100777","DOIUrl":"10.1016/j.xnsj.2025.100777","url":null,"abstract":"<div><h3>Preface</h3><div>On behalf of the NASS section on intraoperative neuromonitoring (IONM), we present a narrative perspective exploring the future of IONM in spine surgery in the US, drawing on current evidence and future projections.</div></div><div><h3>Present state</h3><div>IONM is used during hundreds of thousands of spinal procedures each year to enhance patient safety via real-time neurodiagnostic feedback. The most common service model is an in-room technologist and a remote supervising professional who interprets the neurophysiological data. The primary goal of IONM is to: (1) detect significant signal changes from baseline, (2) identify the cause—whether technical, positional, anesthetic, or iatrogenic, and (3) pinpoint the site of injury. This diagnostic process is time-sensitive, complex, and dependent on both the signal pattern change and patient and procedural factors that are dynamically variable.</div></div><div><h3>Future: integrating and advancing technology</h3><div>Artificial intelligence (AI) and machine learning (ML) hold promise to enhance the accuracy in detecting and interpreting signal changes for IONM clinicians and be integrated into surgeon-directed software platforms. However, widespread AI/ML adoption depends on the availability of large, validated IONM datasets—currently hindered by practice variation, inconsistent perioperative documentation, and unharmonized IONM, anesthetic, surgical, and patient medical records.</div></div><div><h3>Future: maturation in Profession</h3><div>IONM can improve in the consistency in which optimal IONM is delivered, how IONM is utilized with evidence-based planning for alerts, and the collection of harmonized and complete signal and clinical records. Most publications have focused on the diagnostic accuracy of IONM in predicting deficits, but more emphasis is needed on demonstrating the therapeutic impact of interventions to alerts and their role in preventing new deficits.</div></div>","PeriodicalId":34622,"journal":{"name":"North American Spine Society Journal","volume":"24 ","pages":"Article 100777"},"PeriodicalIF":2.5,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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North American Spine Society Journal
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