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P22. Surgical outcomes in cervical ossification of posterior longitudinal ligament: a case series and literature review 第22位。颈椎后纵韧带骨化的手术结果:一个病例系列和文献回顾
Q3 Medicine Pub Date : 2025-07-01 DOI: 10.1016/j.xnsj.2025.100646
Ling Yi Li MD

BACKGROUND CONTEXT

Cervical ossification of the posterior longitudinal ligament (OPLL) can cause symptoms such as myelopathy and radiculopathy. Anterior decompression and fusion (ADF) and laminoplasty (LAMP) are common surgical options to decompress the spinal cord and stabilize the spine. ADF provides direct decompression but is associated with greater complexity and higher risks, whereas LAMP is less invasive but may be less effective in severe cases. Ongoing research aims to compare these approaches and guide the selection of the most appropriate treatment.

PURPOSE

N/A

STUDY DESIGN/SETTING

N/A

PATIENT SAMPLE

N/A

OUTCOME MEASURES

N/A

METHODS

Data collection included demographic characteristics, radiological findings, and the Japanese Orthopaedic Association (JOA) score for cervical myelopathy recorded between 2010 and 2024. Postoperative and last follow-up JOA scores were compared with preoperative values within and between the two groups. Postoperative complications were also assessed. Regression analysis was performed to identify factors associated with achieving a minimal clinically important improvement or difference in the JOA score.

RESULTS

The study analyzed 27 patients who underwent either ADF (n = 18) or LAMP (n = 9). Both groups had comparable demographics, although segmental involvement was more common in the ADF group. Preoperative JOA scores were higher in the ADF group, and postoperative improvements were greater, but recovery rates were similar between the two groups. Complications such as reoperation and C5 palsy occurred only in the ADF group, though these differences were not statistically significant. Surgical site infections were observed exclusively in the LAMP group. Factors such as age, BMI, and smoking history did not significantly influence the MCID, but the occupying ratio showed a potential impact (p = 0.0516), underscoring its role as a nuanced predictor of surgical success.

CONCLUSIONS

Both ADF and LAMP are effective and safe treatments for cervical OPLL. However, patients with a higher occupying ratio may have a reduced likelihood of achieving MCID success.

FDA Device/Drug Status

This abstract does not discuss or include any applicable devices or drugs.
背景背景颈椎后纵韧带骨化可引起脊髓病和神经根病等症状。前路减压融合术(ADF)和椎板成形术(LAMP)是脊髓减压和稳定脊柱的常用手术选择。ADF提供直接减压,但具有更大的复杂性和更高的风险,而LAMP侵入性较小,但在严重病例中可能效果较差。正在进行的研究旨在比较这些方法并指导选择最合适的治疗方法。目的/研究设计/设置/患者样本/结果测量/方法收集的数据包括2010年至2024年间记录的脊髓型颈椎病的人口统计学特征、放射学表现和日本骨科协会(JOA)评分。将两组患者术后和末次随访的JOA评分与术前比较。术后并发症也进行了评估。进行回归分析,以确定与达到最小临床重要改善或JOA评分差异相关的因素。结果本研究分析了27例ADF (n = 18)或LAMP (n = 9)患者。两组具有相似的人口统计学特征,尽管在ADF组中节段性受累更为常见。术前JOA评分较高的ADF组,术后改善更大,但两组之间的恢复率相似。再手术和C5麻痹等并发症仅在ADF组发生,但这些差异无统计学意义。仅在LAMP组观察到手术部位感染。年龄、BMI和吸烟史等因素对MCID没有显著影响,但占位率显示出潜在影响(p = 0.0516),强调其作为手术成功的微妙预测因素的作用。结论ADF和LAMP治疗颈椎OPLL安全有效。然而,占用率较高的患者获得MCID成功的可能性降低。FDA器械/药物状态本摘要不讨论或包括任何适用的器械或药物。
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引用次数: 0
3. Automated Lenke classification for preoperative spine surgery by extracting anatomical landmarks from X-ray images using a deep learning approach 3. 利用深度学习方法从x射线图像中提取解剖标志,实现脊柱术前手术的自动Lenke分类
Q3 Medicine Pub Date : 2025-07-01 DOI: 10.1016/j.xnsj.2025.100697
AliAsghar Mohammadi Nasrabadi PhD , Gemah Moammer FRCSC , John McPhee PhD
<div><h3>BACKGROUND CONTEXT</h3><div>Spinopelvic assessment (eg, SS, PT, PI, LL, TK, CL, SVA, and Cobb angle) is vital for preoperative spinal surgery planning but is often measured manually, leading to variability. Recent AI and deep learning methods improve automation and accuracy. While promising, these techniques face challenges including computational complexity, small test datasets, lack of surgeon validation, and limited robustness to varied image conditions.</div></div><div><h3>PURPOSE</h3><div>To increase accuracy, reduce complexity, and provide robust preoperative X-ray analysis, we propose a novel, physics-informed deep learning method based on mathematical spinal relations. This approach aims to automatically calculate lateral and AP spinal parameters and promptly perform Lenke classification for each patient.</div></div><div><h3>STUDY DESIGN/SETTING</h3><div>N/A</div></div><div><h3>PATIENT SAMPLE</h3><div>We collected 3500 lateral and AP spine X-rays from Grand River Hospital (GRH) in Kitchener, ON, Canada, between 2016 and 2024, encompassing hip/spine implants, varied postures, and poor-contrast or partially visible spines. Image processing filters enhanced annotation accuracy, allowing landmark detection even in incomplete images. The dataset includes conventional and EOS systems, enabling thorough performance evaluation and robust landmark detection. Data was split into 80% training, 10% validation, and 10% testing.</div></div><div><h3>OUTCOME MEASURES</h3><div>This study focuses on the automatic extraction of spinopelvic parameters and anatomical landmarks from lateral and AP X-ray images, including SS, PT, PI, LL, SVA, femur center, sacrum end plate, iliac crest, L1–L5, T12–T1, C7–C2, apex, Cobb angle, LSRS, TSM, and CSRS. These measurements enable Lenke classification, identifying curve types (1–6), lumbar modifiers (A, B, C), and thoracic modifiers (–, N, +). To evaluate performance, we use relative root mean square error (RRMSE) to compare predicted values (PR) with manual annotations (MA), while intraclass correlation coefficient (ICC) measures reliability among surgeons, MA, and PR.</div></div><div><h3>METHODS</h3><div>Using our developed physics-informed deep learning method, spinopelvic parameters were extracted from X-ray images and validated against manual annotations. Landmarks were detected as objects with geometric constraints derived from mathematical spinal relations. Performance, compared to three senior spine surgeons, demonstrated excellent correlation, with intraclass correlation coefficients exceeding 0.9, surpassing previously reported literature values. Additionally, we developed an algorithm leveraging these parameters to automate Lenke classification, identifying curve type (1–6), lumbar modifier (A,B,C), and thoracic modifier (–,N,+), significantly aiding triage and preoperative planning.</div></div><div><h3>RESULTS</h3><div>We evaluated our model on the dataset, achieving final accuracies of 93.1% (SS),
脊柱骨盆评估(如SS、PT、PI、LL、TK、CL、SVA和Cobb角)对术前脊柱手术计划至关重要,但通常是人工测量,导致差异。最近的人工智能和深度学习方法提高了自动化和准确性。虽然这些技术很有前景,但也面临着计算复杂性、测试数据集小、缺乏外科医生验证以及对不同图像条件的鲁棒性有限等挑战。为了提高准确性,降低复杂性,并提供强大的术前x线分析,我们提出了一种基于数学脊柱关系的新颖的物理信息深度学习方法。该方法旨在自动计算侧位和侧位脊柱参数,并及时对每位患者进行Lenke分类。研究设计/环境/患者样本:我们在2016年至2024年期间从加拿大安大略省基奇纳的大河医院(GRH)收集了3500张侧位和正位脊柱x光片,包括髋关节/脊柱植入物、不同姿势、对比度较差或部分可见的脊柱。图像处理过滤器提高了标注精度,即使在不完整的图像中也可以进行地标检测。该数据集包括传统和EOS系统,能够进行全面的性能评估和稳健的地标检测。数据被分成80%的训练、10%的验证和10%的测试。本研究重点从侧位和正位x线图像中自动提取脊柱参数和解剖标志,包括SS、PT、PI、LL、SVA、股骨中心、骶骨终板、髂骨、L1-L5、T12-T1、C7-C2、尖端、Cobb角、LSRS、TSM和CSRS。这些测量可以进行Lenke分类,识别曲线类型(1-6),腰椎调节因子(A, B, C)和胸部调节因子(-,N, +)。为了评估性能,我们使用相对均方根误差(RRMSE)来比较预测值(PR)与手动注释(MA),而类内相关系数(ICC)衡量外科医生、MA和PR之间的可靠性。方法使用我们开发的物理信息深度学习方法,从x射线图像中提取脊柱参数,并根据手动注释进行验证。地标被检测为具有几何约束的对象,这些约束来源于数学脊柱关系。与三位资深脊柱外科医生相比,表现出良好的相关性,类内相关系数超过0.9,超过先前报道的文献值。此外,我们开发了一种算法,利用这些参数来自动进行Lenke分类,识别曲线类型(1-6),腰椎修饰符(A,B,C)和胸椎修饰符(-,N,+),显著帮助分诊和术前计划。结果我们在数据集上评估了我们的模型,最终准确率为93.1% (SS), 94.6% (PT), 93.4% (Cobb角),91.2% (LL)和94.5% (SVA)。通过我们基于lenke的自动算法,患者分类准确率达到98.5%。总体而言,该模型超越了文献报道的准确性,展示了稳健的性能和可靠性。为了与外科医生进行比较,我们使用了三个外科医生注释的类内相关系数(ICC),显示出比以前报道的更强的一致性。结论基于物理的深度学习方法可靠地实现了脊柱参数的自动提取和分类,实现了高精度和鲁棒外科水平的一致性,从而推进了脊柱术前规划,指导了人工智能创新。FDA器械/药物状态本摘要不讨论或包括任何适用的器械或药物。
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引用次数: 0
List of Contents 目录一览表
Q3 Medicine Pub Date : 2025-07-01 DOI: 10.1016/S2666-5484(25)00182-9
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引用次数: 0
44. Development of a novel machine learning model for prediction of adjacent fracture after cementoplasty in treating osteoporotic vertebral compression fracture 44. 骨质疏松性椎体压缩性骨折骨质疏松性椎体骨水泥成形术后邻近骨折预测的新型机器学习模型的建立
Q3 Medicine Pub Date : 2025-07-01 DOI: 10.1016/j.xnsj.2025.100738
Yu-Cheng Yao MD , Po-Hsin Chou MD , Bruce H Lin MD , Shih-Tien Wang MD
<div><h3>BACKGROUND CONTEXT</h3><div>There are approximately 30% of patients with osteoporotic vertebral compression fracture (OVCF) who need cementoplasty for treatment. However, the occurrence of adjacent vertebral fracture (AVF) postoperatively can lead to increased pain, delayed recovery, and poorer prognosis. Current literature identifies over 30 risk factors for AVF, including patient-specific factors, preoperative and postoperative radiographical features, and surgical-related factors. There is no effective predictive model in understanding the probability of AVF occurrence preoperatively.</div></div><div><h3>PURPOSE</h3><div>This study aims to develop a robust AVF predictive model using machine learning method.</div></div><div><h3>STUDY DESIGN/SETTING</h3><div>Retrospective cohort study.</div></div><div><h3>PATIENT SAMPLE</h3><div>A total of 238 patients with OVCF who underwent single level cementoplasty were included for analysis.</div></div><div><h3>OUTCOME MEASURES</h3><div>Adjacent fracture.</div></div><div><h3>METHODS</h3><div>This is a retrospective cohort analysis. Patients with OVCF who underwent single level cementoplasty between January 2016 and December 2021 were included. Exclusion criteria were pathological fractures, patients with prior cementoplasty or spinal surgeries, and follow-up less than 12 months. Total 32 preoperative clinical and radiographic features were recorded, include patient demographics, DXA, chronic diseases, vertebral height (VH), wedge angle (WA) of fracture vertebra, local kyphotic angle (LKA), presence of posterior wall fracture (PostWall), and presence of diffuse idiopathic skeletal hyperostosis (DISH), CT vertebral Hounsfield units (HU), CT psoas lumbar vertebral index (PLVI). Ten different machine learning algorithms were used to find the best model. Confusion matrix and related indicators include Accuracy, sensitivity (Se), specificity (Sp) and ROC-AUC were used to evaluate the model performance.</div></div><div><h3>RESULTS</h3><div>A total of 238 patients were included for analysis, with an average age of 77 years and 69% were female. Most fractures located at the TL junction (64%). The AVF rate was 27.3% during the follow-up and it occurred at postoperative 3.2 months. We found the random forest model had the best performance with 83% accuracy, AUC 0.92, Se: 82%, and Sp: 85%. Among the total 32 features, we found that the 11 most important features by orders were PostWall, HU_L2, DISH, L4_PLVI, WA, MVH, BMI, LKA, Age, and fracture level. Even using those 11 features alone, the model performance could reach 78% accuracy, AUC 0.88, Se: 80%, and Sp 76%.</div></div><div><h3>CONCLUSIONS</h3><div>The novel machine learning model for predicting AVF using preoperative features demonstrated excellent performance, achieving an AUC of 0.92. This model can assist clinicians and patients with OVCF in understanding the probability of AVF occurrence after cementoplasty. For patients identified as high-risk, pro
大约30%的骨质疏松性椎体压缩性骨折(OVCF)患者需要骨水泥成形术进行治疗。然而,术后发生相邻椎体骨折(AVF)可导致疼痛增加,恢复延迟,预后较差。目前的文献确定了30多种AVF的危险因素,包括患者特异性因素、术前和术后影像学特征以及手术相关因素。术前没有有效的预测模型来了解AVF发生的概率。目的利用机器学习方法建立稳健的AVF预测模型。研究设计/设置:回顾性队列研究。患者SAMPLEA共纳入238例接受单水平骨水泥成形术的OVCF患者进行分析。结果:邻近骨折。方法回顾性队列分析。在2016年1月至2021年12月期间接受单节段骨水泥成形术的OVCF患者纳入研究。排除标准为病理性骨折,既往骨质成形术或脊柱手术患者,随访时间少于12个月。共记录32个术前临床和影像学特征,包括患者人口统计学特征、DXA、慢性疾病、椎体高度(VH)、骨折椎体楔形角(WA)、局部后凸角(LKA)、是否存在后壁骨折(PostWall)、是否存在弥漫性特发性骨骼肥厚(DISH)、CT椎体Hounsfield单位(HU)、CT腰椎间盘指数(PLVI)。使用了10种不同的机器学习算法来寻找最佳模型。使用混淆矩阵及相关指标准确性、敏感性(Se)、特异性(Sp)和ROC-AUC来评价模型的性能。结果238例患者纳入分析,平均年龄77岁,女性占69%。大多数骨折位于左端交界处(64%)。随访期间AVF发生率为27.3%,发生于术后3.2个月。我们发现随机森林模型具有最佳性能,准确率为83%,AUC为0.92,Se为82%,Sp为85%。在32个特征中,我们发现按顺序排列最重要的11个特征是PostWall、HU_L2、DISH、L4_PLVI、WA、MVH、BMI、LKA、Age和骨折程度。即使仅使用这11个特征,模型性能也可以达到78%的准确率,AUC为0.88,Se为80%,Sp为76%。结论利用术前特征预测AVF的机器学习模型表现优异,AUC为0.92。该模型可以帮助临床医生和OVCF患者了解骨水泥成形术后AVF发生的概率。对于确定为高危的患者,预防性相邻水平的骨水泥成形术或其他医疗干预可能会带来一些好处。FDA器械/药物状态本摘要不讨论或包括任何适用的器械或药物。
{"title":"44. Development of a novel machine learning model for prediction of adjacent fracture after cementoplasty in treating osteoporotic vertebral compression fracture","authors":"Yu-Cheng Yao MD ,&nbsp;Po-Hsin Chou MD ,&nbsp;Bruce H Lin MD ,&nbsp;Shih-Tien Wang MD","doi":"10.1016/j.xnsj.2025.100738","DOIUrl":"10.1016/j.xnsj.2025.100738","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;BACKGROUND CONTEXT&lt;/h3&gt;&lt;div&gt;There are approximately 30% of patients with osteoporotic vertebral compression fracture (OVCF) who need cementoplasty for treatment. However, the occurrence of adjacent vertebral fracture (AVF) postoperatively can lead to increased pain, delayed recovery, and poorer prognosis. Current literature identifies over 30 risk factors for AVF, including patient-specific factors, preoperative and postoperative radiographical features, and surgical-related factors. There is no effective predictive model in understanding the probability of AVF occurrence preoperatively.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;PURPOSE&lt;/h3&gt;&lt;div&gt;This study aims to develop a robust AVF predictive model using machine learning method.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;STUDY DESIGN/SETTING&lt;/h3&gt;&lt;div&gt;Retrospective cohort study.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;PATIENT SAMPLE&lt;/h3&gt;&lt;div&gt;A total of 238 patients with OVCF who underwent single level cementoplasty were included for analysis.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;OUTCOME MEASURES&lt;/h3&gt;&lt;div&gt;Adjacent fracture.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;METHODS&lt;/h3&gt;&lt;div&gt;This is a retrospective cohort analysis. Patients with OVCF who underwent single level cementoplasty between January 2016 and December 2021 were included. Exclusion criteria were pathological fractures, patients with prior cementoplasty or spinal surgeries, and follow-up less than 12 months. Total 32 preoperative clinical and radiographic features were recorded, include patient demographics, DXA, chronic diseases, vertebral height (VH), wedge angle (WA) of fracture vertebra, local kyphotic angle (LKA), presence of posterior wall fracture (PostWall), and presence of diffuse idiopathic skeletal hyperostosis (DISH), CT vertebral Hounsfield units (HU), CT psoas lumbar vertebral index (PLVI). Ten different machine learning algorithms were used to find the best model. Confusion matrix and related indicators include Accuracy, sensitivity (Se), specificity (Sp) and ROC-AUC were used to evaluate the model performance.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;RESULTS&lt;/h3&gt;&lt;div&gt;A total of 238 patients were included for analysis, with an average age of 77 years and 69% were female. Most fractures located at the TL junction (64%). The AVF rate was 27.3% during the follow-up and it occurred at postoperative 3.2 months. We found the random forest model had the best performance with 83% accuracy, AUC 0.92, Se: 82%, and Sp: 85%. Among the total 32 features, we found that the 11 most important features by orders were PostWall, HU_L2, DISH, L4_PLVI, WA, MVH, BMI, LKA, Age, and fracture level. Even using those 11 features alone, the model performance could reach 78% accuracy, AUC 0.88, Se: 80%, and Sp 76%.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;CONCLUSIONS&lt;/h3&gt;&lt;div&gt;The novel machine learning model for predicting AVF using preoperative features demonstrated excellent performance, achieving an AUC of 0.92. This model can assist clinicians and patients with OVCF in understanding the probability of AVF occurrence after cementoplasty. For patients identified as high-risk, pro","PeriodicalId":34622,"journal":{"name":"North American Spine Society Journal","volume":"22 ","pages":"Article 100738"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144672416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
P11. Endoscopic decompression for radiculopathy in scoliosis 侯。脊柱侧凸神经根病的内镜减压治疗
Q3 Medicine Pub Date : 2025-07-01 DOI: 10.1016/j.xnsj.2025.100635
Jun Rui Don Koh MBChB, BS

BACKGROUND CONTEXT

Adult degenerative scoliosis is a spinal deformity resulting in an unbalanced spine, the further progression of which results in associated conditions such as disc herniation, ligament hypertrophy and facet ossification. Patients with scoliosis therefore frequently suffer from both axial back pain as well as radicular pain.

PURPOSE

N/A

STUDY DESIGN/SETTING

Case Series

PATIENT SAMPLE

N/A

OUTCOME MEASURES

N/A

METHODS

We report a case series of two middle aged patients with severe scoliosis who presented to our department complaining of both back and radicular pain.

RESULTS

These patients subsequently underwent minimally invasive endoscopic decompression of the affected levels following a failure of conservative management, with no fusion to address the scoliosis. The patients report good relief of their radicular pain post-operatively, although the axial back pain remained.

CONCLUSIONS

Endoscopic decompression is a potential surgical option which should be considered for the management of radicular pain in patients with scoliosis.

FDA Device/Drug Status

This abstract does not discuss or include any applicable devices or drugs.
成人退行性脊柱侧凸是一种脊柱畸形,导致脊柱不平衡,其进一步进展会导致相关疾病,如椎间盘突出、韧带肥大和小关节面骨化。因此,脊柱侧凸患者经常遭受轴性背痛和神经根性背痛。目的/研究设计/设置病例系列患者样本/结果测量/方法我们报告了两例中年严重脊柱侧凸患者的病例系列,他们到我科就诊,主诉背部和神经根疼痛。结果这些患者在保守治疗失败后接受了微创内窥镜减压,没有融合来解决脊柱侧凸。患者报告术后神经根痛得到了很好的缓解,但腰背痛仍然存在。结论内镜下减压术是治疗脊柱侧凸患者神经根性疼痛的一种可行的手术方法。FDA器械/药物状态本摘要不讨论或包括任何适用的器械或药物。
{"title":"P11. Endoscopic decompression for radiculopathy in scoliosis","authors":"Jun Rui Don Koh MBChB, BS","doi":"10.1016/j.xnsj.2025.100635","DOIUrl":"10.1016/j.xnsj.2025.100635","url":null,"abstract":"<div><h3>BACKGROUND CONTEXT</h3><div>Adult degenerative scoliosis is a spinal deformity resulting in an unbalanced spine, the further progression of which results in associated conditions such as disc herniation, ligament hypertrophy and facet ossification. Patients with scoliosis therefore frequently suffer from both axial back pain as well as radicular pain.</div></div><div><h3>PURPOSE</h3><div>N/A</div></div><div><h3>STUDY DESIGN/SETTING</h3><div>Case Series</div></div><div><h3>PATIENT SAMPLE</h3><div>N/A</div></div><div><h3>OUTCOME MEASURES</h3><div>N/A</div></div><div><h3>METHODS</h3><div>We report a case series of two middle aged patients with severe scoliosis who presented to our department complaining of both back and radicular pain.</div></div><div><h3>RESULTS</h3><div>These patients subsequently underwent minimally invasive endoscopic decompression of the affected levels following a failure of conservative management, with no fusion to address the scoliosis. The patients report good relief of their radicular pain post-operatively, although the axial back pain remained.</div></div><div><h3>CONCLUSIONS</h3><div>Endoscopic decompression is a potential surgical option which should be considered for the management of radicular pain in patients with scoliosis.</div></div><div><h3>FDA Device/Drug Status</h3><div>This abstract does not discuss or include any applicable devices or drugs.</div></div>","PeriodicalId":34622,"journal":{"name":"North American Spine Society Journal","volume":"22 ","pages":"Article 100635"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144672424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
27. Open door versus double door laminoplasty in the treatment of cervical OPLL: a 10-year retrospective analysis 27. 开放门与双门椎板成形术治疗颈椎OPLL: 10年回顾性分析
Q3 Medicine Pub Date : 2025-07-01 DOI: 10.1016/j.xnsj.2025.100721
Sunjoon Yoo MD
<div><h3>BACKGROUND CONTEXT</h3><div>Cervical ossification of the posterior longitudinal ligament (OPLL) is a common cause of cervical myelopathy, often requiring surgical intervention. Laminoplasty, with two main approaches—open-door (OD) and double-door (DD)—is widely performed. However, while previous studies have reported on the clinical and radiological outcomes of these techniques, none have examined a 10-year follow-up with a significant number of patients.</div></div><div><h3>PURPOSE</h3><div>This study aims to compare the long-term outcomes of open-door and double-door laminoplasties in patients with cervical OPLL over a 10-year follow-up period.</div></div><div><h3>STUDY DESIGN/SETTING</h3><div>A 10-year retrospective cohort analysis conducted at a single institution.</div></div><div><h3>PATIENT SAMPLE</h3><div>A total of 109 patients with cervical OPLL, comprising 63 patients in the open-door laminoplasty group and 46 patients in the double-door laminoplasty group.</div></div><div><h3>OUTCOME MEASURES</h3><div>The clinical outcomes assessed in this study included Visual Analog Scale (VAS) scores, Japanese Orthopedic Association (JOA) scores, and recovery rates. Radiological outcomes evaluated were the C2-7 Cobb angle, range of motion (ROM), occupying ratio, and K-line type.</div></div><div><h3>METHODS</h3><div>For cervical myelopathy caused by OPLL, we performed OD and double-door DD laminopasties at a single institution. A total of 63 patients in the OD group and 46 patients in the DD group were evaluated for 10 years’ follow-up. The following criteria were evaluated: demographic information, range of operation, occupying ratio, K-line, type of OPLL, Cobb angle of C2-C7, and range of motion. Clinical outcomes were assessed using the VAS, JOA score and recovery rate.</div></div><div><h3>RESULTS</h3><div>Age, sex, symptom duration, and comorbidities were not significantly different between the groups. No significant differences in K-line type, canal occupying ratio were found. There were 6 patients in each group who underwent reoperation. Between the two groups, there was no difference in the change in the C2-7 cobb angle preoperative, immediate after surgery, and 2 years after surgery. However, at 10 years after surgery, the angle during extension decreased in the DD group, and the ROM also decreased statistically significantly (12.61 vs 8.4, p=0.02; 18.87 vs 13.62, p=0.016). However, the ROM decreased in both groups from before surgery to the last follow-up, with no significant difference (-14.43 vs -18.07, p=0.221). The VAS scores for neck and arm were significantly lower in the DD group immediately after surgery (p=0.044, 0.022), but no difference was observed between the groups 10 years post-surgery. JOA scores showed a similar improvement 10 years postoperatively.</div></div><div><h3>CONCLUSIONS</h3><div>Both laminoplasty methods are effective for treating cervical OPLL over a 10-year period. However, the ROM decreased significant
背景背景后纵韧带颈椎骨化(OPLL)是颈椎病的常见病因,通常需要手术干预。椎板成形术有两种主要的方法-开门(OD)和双门(DD) -被广泛应用。然而,尽管先前的研究报道了这些技术的临床和放射学结果,但没有一项研究对大量患者进行了10年的随访。目的:本研究旨在比较开放门和双门椎板成形术在10年随访期间对颈椎OPLL患者的长期疗效。研究设计/设置在单一机构进行的10年回顾性队列分析。患者共109例颈椎OPLL患者,其中开门椎板成形术组63例,双门椎板成形术组46例。本研究评估的临床结果包括视觉模拟量表(VAS)评分、日本骨科协会(JOA)评分和康复率。影像学结果评估为C2-7 Cobb角、活动范围(ROM)、占位率和k线类型。方法:对于OPLL所致的颈椎病,我们在同一家机构进行了OD和双门DD椎板手术。OD组共63例,DD组46例,随访10年。评估标准如下:人口统计学信息、操作范围、占位率、k线、OPLL类型、C2-C7 Cobb角和活动范围。采用VAS评分、JOA评分和康复率评估临床结果。结果两组患者年龄、性别、症状持续时间、合并症无显著差异。k线型、管占比差异无统计学意义。两组再手术6例。两组患者术前、术后即刻、术后2年的C2-7 cobb角变化无差异。然而,在手术后10年,DD组伸展时的角度减小,ROM也有统计学意义(12.61 vs 8.4, p=0.02;18.87 vs 13.62, p=0.016)。然而,从术前到最后一次随访,两组的ROM均下降,差异无统计学意义(-14.43 vs -18.07, p=0.221)。DD组术后即刻颈部和手臂VAS评分明显降低(p=0.044, 0.022),但术后10年各组间无差异。术后10年JOA评分也有类似的改善。结论两种椎板成形术均可有效治疗10年以上的颈椎上睑下垂。然而,在DD组中,ROM明显下降得更多。尽管如此,两组在JOA评分方面表现出相似的长期临床结果和改善。FDA器械/药物状态本摘要不讨论或包括任何适用的器械或药物。
{"title":"27. Open door versus double door laminoplasty in the treatment of cervical OPLL: a 10-year retrospective analysis","authors":"Sunjoon Yoo MD","doi":"10.1016/j.xnsj.2025.100721","DOIUrl":"10.1016/j.xnsj.2025.100721","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;BACKGROUND CONTEXT&lt;/h3&gt;&lt;div&gt;Cervical ossification of the posterior longitudinal ligament (OPLL) is a common cause of cervical myelopathy, often requiring surgical intervention. Laminoplasty, with two main approaches—open-door (OD) and double-door (DD)—is widely performed. However, while previous studies have reported on the clinical and radiological outcomes of these techniques, none have examined a 10-year follow-up with a significant number of patients.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;PURPOSE&lt;/h3&gt;&lt;div&gt;This study aims to compare the long-term outcomes of open-door and double-door laminoplasties in patients with cervical OPLL over a 10-year follow-up period.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;STUDY DESIGN/SETTING&lt;/h3&gt;&lt;div&gt;A 10-year retrospective cohort analysis conducted at a single institution.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;PATIENT SAMPLE&lt;/h3&gt;&lt;div&gt;A total of 109 patients with cervical OPLL, comprising 63 patients in the open-door laminoplasty group and 46 patients in the double-door laminoplasty group.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;OUTCOME MEASURES&lt;/h3&gt;&lt;div&gt;The clinical outcomes assessed in this study included Visual Analog Scale (VAS) scores, Japanese Orthopedic Association (JOA) scores, and recovery rates. Radiological outcomes evaluated were the C2-7 Cobb angle, range of motion (ROM), occupying ratio, and K-line type.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;METHODS&lt;/h3&gt;&lt;div&gt;For cervical myelopathy caused by OPLL, we performed OD and double-door DD laminopasties at a single institution. A total of 63 patients in the OD group and 46 patients in the DD group were evaluated for 10 years’ follow-up. The following criteria were evaluated: demographic information, range of operation, occupying ratio, K-line, type of OPLL, Cobb angle of C2-C7, and range of motion. Clinical outcomes were assessed using the VAS, JOA score and recovery rate.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;RESULTS&lt;/h3&gt;&lt;div&gt;Age, sex, symptom duration, and comorbidities were not significantly different between the groups. No significant differences in K-line type, canal occupying ratio were found. There were 6 patients in each group who underwent reoperation. Between the two groups, there was no difference in the change in the C2-7 cobb angle preoperative, immediate after surgery, and 2 years after surgery. However, at 10 years after surgery, the angle during extension decreased in the DD group, and the ROM also decreased statistically significantly (12.61 vs 8.4, p=0.02; 18.87 vs 13.62, p=0.016). However, the ROM decreased in both groups from before surgery to the last follow-up, with no significant difference (-14.43 vs -18.07, p=0.221). The VAS scores for neck and arm were significantly lower in the DD group immediately after surgery (p=0.044, 0.022), but no difference was observed between the groups 10 years post-surgery. JOA scores showed a similar improvement 10 years postoperatively.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;CONCLUSIONS&lt;/h3&gt;&lt;div&gt;Both laminoplasty methods are effective for treating cervical OPLL over a 10-year period. However, the ROM decreased significant","PeriodicalId":34622,"journal":{"name":"North American Spine Society Journal","volume":"22 ","pages":"Article 100721"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144672448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
P2. Concurrent intramedullary cervical spine abscess and intraventricular empyema P2。并发髓内颈椎脓肿和脑室脓肿
Q3 Medicine Pub Date : 2025-07-01 DOI: 10.1016/j.xnsj.2025.100626
Shao Lun Chen MD
<div><h3>BACKGROUND CONTEXT</h3><div>Intramedullary spinal cord abscess (ISCA) and intraventricular empyema are both rare, severe infections that can result in significant neurological impairment or death if not managed promptly. Although each condition alone poses diagnostic and therapeutic challenges, the simultaneous occurrence of ISCA and intraventricular empyema is exceedingly uncommon. Recognizing these pathologies early and initiating aggressive treatment is essential to prevent irreversible CNS damage.</div></div><div><h3>PURPOSE</h3><div>To present a rare case of concurrent cervical intramedullary spinal cord abscess and intraventricular empyema, highlighting the diagnostic difficulties, the necessity of early surgical intervention, and the importance of comprehensive antibiotic coverage in managing complex central nervous system infections.</div></div><div><h3>STUDY DESIGN/SETTING</h3><div>This is a single-patient case report treated at a tertiary neurosurgical center, coupled with a review of the pertinent literature to contextualize the rarity and management of such concurrent CNS infections.</div></div><div><h3>PATIENT SAMPLE</h3><div>A 43-year-old female patient, with a history of cervical spine surgery (for ossification of the posterior longitudinal ligament), presented with a two-week history of fever, acute left upper limb weakness, numbness, and neck pain.</div></div><div><h3>OUTCOME MEASURES</h3><div>Key measures included neurological status (motor strength, level of consciousness), radiological evolution of the spinal and intraventricular infections (MRI findings), and response to antimicrobial therapy and surgical interventions (abscess drainage, external ventricular drainage, and shunt placement).</div></div><div><h3>METHODS</h3><div>An urgent surgical decompression and drainage of the intramedullary abscess at the C3–4 level was performed via a posterior approach. Antibiotics were initially broad-spectrum, then tailored to culture results identifying oral flora (Prevotella species and Fusobacterium nucleatum). When the patient’s mental status worsened, follow-up brain imaging revealed intraventricular empyema, requiring external ventricular drainage. After infection control was achieved, ventriculoperitoneal shunts were placed to address persistent hydrocephalus.</div></div><div><h3>RESULTS</h3><div>Despite initial deterioration in motor strength post-surgery, the patient demonstrated gradual neurological improvement with appropriate antibiotic therapy and serial interventions for both the spinal cord abscess and the intraventricular empyema. Final discharge status showed partial but meaningful recovery of left-sided strength, normal alertness, and resolution of severe headaches attributed to hydrocephalus.</div></div><div><h3>CONCLUSIONS</h3><div>Concurrent spinal cord abscess and intraventricular empyema demand high clinical suspicion and a coordinated, multidisciplinary approach. Early recognition, comprehensive antibiot
背景:髓内脊髓脓肿(ISCA)和脑室脓肿都是罕见的严重感染,如果不及时处理,可导致严重的神经损伤或死亡。虽然每一个条件单独提出诊断和治疗的挑战,ISCA和脑室内脓肿同时发生是非常罕见的。早期识别这些病理并开始积极治疗对于防止不可逆的中枢神经系统损伤至关重要。目的报告1例罕见的颈髓内脊髓脓肿合并脑室脓肿,强调诊断困难,早期手术干预的必要性,以及综合应用抗生素治疗复杂中枢神经系统感染的重要性。研究设计/背景:这是一个在三级神经外科中心治疗的单例病例报告,结合相关文献的回顾,以了解此类并发中枢神经系统感染的罕见性和管理。患者SAMPLEA, 43岁,女,颈椎手术史(后纵韧带骨化),两周发热,急性左上肢无力,麻木,颈部疼痛。主要测量指标包括神经系统状态(运动强度、意识水平)、脊柱和脑室内感染的放射学进展(MRI结果)、对抗菌治疗和手术干预(脓肿引流、脑室外引流和分流器放置)的反应。方法经后路行C3-4节段髓内脓肿紧急减压引流术。抗生素最初是广谱的,然后根据培养结果确定口腔菌群(普雷沃氏菌和核梭杆菌)。当患者精神状态恶化时,随访的脑成像显示脑室内脓胸,需要脑室外引流。感染得到控制后,放置脑室-腹膜分流以解决持续性脑积水。结果:尽管术后患者的运动力量开始恶化,但通过适当的抗生素治疗和脊髓脓肿和脑室内脓肿的一系列干预,患者的神经系统逐渐改善。最终出院状态显示左侧力量部分恢复,警觉性正常,脑积水引起的严重头痛得到解决。结论并发性脊髓脓肿和脑室内脓肿需要高度的临床怀疑和协调的多学科治疗。早期识别、全面的抗生素覆盖(包括对潜在口腔菌群的覆盖)、脓肿的彻底手术减压以及及时处理脑积水等继发性并发症是优化患者预后的关键。FDA器械/药物状态本摘要不讨论或包括任何适用的器械或药物。
{"title":"P2. Concurrent intramedullary cervical spine abscess and intraventricular empyema","authors":"Shao Lun Chen MD","doi":"10.1016/j.xnsj.2025.100626","DOIUrl":"10.1016/j.xnsj.2025.100626","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;BACKGROUND CONTEXT&lt;/h3&gt;&lt;div&gt;Intramedullary spinal cord abscess (ISCA) and intraventricular empyema are both rare, severe infections that can result in significant neurological impairment or death if not managed promptly. Although each condition alone poses diagnostic and therapeutic challenges, the simultaneous occurrence of ISCA and intraventricular empyema is exceedingly uncommon. Recognizing these pathologies early and initiating aggressive treatment is essential to prevent irreversible CNS damage.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;PURPOSE&lt;/h3&gt;&lt;div&gt;To present a rare case of concurrent cervical intramedullary spinal cord abscess and intraventricular empyema, highlighting the diagnostic difficulties, the necessity of early surgical intervention, and the importance of comprehensive antibiotic coverage in managing complex central nervous system infections.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;STUDY DESIGN/SETTING&lt;/h3&gt;&lt;div&gt;This is a single-patient case report treated at a tertiary neurosurgical center, coupled with a review of the pertinent literature to contextualize the rarity and management of such concurrent CNS infections.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;PATIENT SAMPLE&lt;/h3&gt;&lt;div&gt;A 43-year-old female patient, with a history of cervical spine surgery (for ossification of the posterior longitudinal ligament), presented with a two-week history of fever, acute left upper limb weakness, numbness, and neck pain.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;OUTCOME MEASURES&lt;/h3&gt;&lt;div&gt;Key measures included neurological status (motor strength, level of consciousness), radiological evolution of the spinal and intraventricular infections (MRI findings), and response to antimicrobial therapy and surgical interventions (abscess drainage, external ventricular drainage, and shunt placement).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;METHODS&lt;/h3&gt;&lt;div&gt;An urgent surgical decompression and drainage of the intramedullary abscess at the C3–4 level was performed via a posterior approach. Antibiotics were initially broad-spectrum, then tailored to culture results identifying oral flora (Prevotella species and Fusobacterium nucleatum). When the patient’s mental status worsened, follow-up brain imaging revealed intraventricular empyema, requiring external ventricular drainage. After infection control was achieved, ventriculoperitoneal shunts were placed to address persistent hydrocephalus.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;RESULTS&lt;/h3&gt;&lt;div&gt;Despite initial deterioration in motor strength post-surgery, the patient demonstrated gradual neurological improvement with appropriate antibiotic therapy and serial interventions for both the spinal cord abscess and the intraventricular empyema. Final discharge status showed partial but meaningful recovery of left-sided strength, normal alertness, and resolution of severe headaches attributed to hydrocephalus.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;CONCLUSIONS&lt;/h3&gt;&lt;div&gt;Concurrent spinal cord abscess and intraventricular empyema demand high clinical suspicion and a coordinated, multidisciplinary approach. Early recognition, comprehensive antibiot","PeriodicalId":34622,"journal":{"name":"North American Spine Society Journal","volume":"22 ","pages":"Article 100626"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144672512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
P7. Clinical and radiologic outcomes of the use of interlaminar device (Coflex®) among patients with low-grade lumbar spondylolisthesis: a single center study 第七页。轻度腰椎滑脱患者使用椎板间装置(Coflex®)的临床和放射学结果:一项单中心研究
Q3 Medicine Pub Date : 2025-07-01 DOI: 10.1016/j.xnsj.2025.100631
Katrina Ysabel Naraval MD , Mikhail Lew Perez Ver MD
<div><h3>BACKGROUND CONTEXT</h3><div>Lumbar spinal fusion relieves pain in degenerative spondylolisthesis (DLS) but carries postoperative risks, including pseudoarthrosis and adjacent segment degeneration and disease, which may eventually lead to reoperation. Dynamic stabilizers, like Coflex® interlaminar device, preserve motion while ensuring stability, providing symptom relief with fewer complications and a reduced risk profile. Though research varies, recent studies highlight their benefits in low-grade DLS.</div></div><div><h3>PURPOSE</h3><div>This study evaluated the radiologic and clinical effectiveness of Coflex® after decompression for low-grade DLS, with follow-ups at 1 to up to 6 years to assess outcomes and complications.</div></div><div><h3>STUDY DESIGN/SETTING</h3><div>This is an analytical retrospective cohort study from a single tertiary center including patients who had low-grade spondylolisthesis (Meyerding Gr I) and was treated with lumbar decompression with consequent interlaminar device (Coflex®) application performed by two fellowship-trained spine surgeons between January 1, 2017 and June 31, 2023. Ethical clearance was obtained (SL-23278).</div></div><div><h3>PATIENT SAMPLE</h3><div>Forty-seven patients who had low-grade spondylolisthesis (Meyerding Gr I) and treated with lumbar decompression with consequent interlaminar device (Coflex®) application were included.</div></div><div><h3>OUTCOME MEASURES</h3><div>Radiographic parameters – lumbar lordosis (LL), lower lumbar lordosis (LLL), intervertebral disc height (IDH), intervertebral foramen height (IFH), and vertebral translation (VT) – were obtained. Clinical outcomes were evaluated by visual analogue scale (VAS) and Oswestry disability Index (ODI).</div></div><div><h3>METHODS</h3><div>Primary outcomes were categorized as radiographic and clinical. Radiographic parameters and functional outcomes included were assessed preoperatively, postoperatively, at 1-year follow-up, and at =1-year follow-up. Descriptive statistics (mean, range, SD, frequency, percentage) were calculated. A paired Student*s t-test assessed differences in radiographic parameters and clinical outcomes. Comparisons were made across preoperative, immediate postoperative, 12-month follow-up, and latest follow-up (=1 year). Linear mixed model analysis with compound symmetry evaluated significant changes over time. Statistical significance was set at p< 0.05.</div></div><div><h3>RESULTS</h3><div>A total of 47 patients (mean age 57 years, range 30-92) with 50 implanted levels were included in the study. Following surgical decompression and interlaminar device placement, LL showed a slight but non-significant decrease [42.89° ± 10.08 to 40.33° ± 8.30 (p = 0.059)] and remained stable, while LLL remained unchanged. VT improved significantly from 3.82 mm ± 3.66 mm to 1.53 mm ± 1.84 mm (p < 0.001) and remained stable until the final follow-up (p = 0.922). IDH increased significantly from 10.23 mm ± 2.33 to 12
背景:腰椎融合术可缓解退行性椎体滑脱(DLS)患者的疼痛,但术后存在风险,包括假关节和邻近节段退变和疾病,最终可能导致再次手术。动态稳定器,如Coflex®椎间装置,在确保稳定性的同时保持运动,提供症状缓解,减少并发症和降低风险。尽管研究各不相同,但最近的研究强调了它们对低度DLS的益处。目的:本研究评估Coflex®减压治疗低级别DLS后的放射学和临床效果,随访1至6年,以评估结果和并发症。研究设计/背景:这是一项来自单一三级中心的分析性回顾性队列研究,纳入了由两名接受过奖学金培训的脊柱外科医生在2017年1月1日至2023年6月31日期间进行腰椎减压并随后应用椎板间装置(Coflex®)治疗的轻度腰椎滑脱(Meyerding Gr I)患者。获得伦理许可(SL-23278)。47例轻度椎体滑脱(Meyerding Gr I)患者接受腰椎减压并应用椎间装置(Coflex®)治疗。结果测量获得影像学参数——腰椎前凸(LL)、下腰椎前凸(LL)、椎间盘高度(IDH)、椎间孔高度(IFH)和椎体平移(VT)。采用视觉模拟评分(VAS)和Oswestry残疾指数(ODI)评价临床结果。方法主要结果分为影像学和临床两大类。术前、术后、随访1年和随访1年分别评估影像学参数和功能指标。计算描述性统计(平均值、极差、标准差、频率、百分比)。配对Student*s t检验评估放射学参数和临床结果的差异。比较术前、术后即刻、12个月随访和最近随访(=1年)。复合对称的线性混合模型分析评估了随时间的显著变化。统计学意义设为p<;0.05.结果共纳入47例患者,平均年龄57岁,30 ~ 92岁,植入50个水平。手术减压和置入椎板间装置后,LL有轻微但不显著的下降[42.89°±10.08至40.33°±8.30 (p = 0.059)]并保持稳定,而LL保持不变。VT由3.82 mm±3.66 mm显著改善至1.53 mm±1.84 mm (p <;0.001),并保持稳定,直到最后随访(p = 0.922)。IDH从10.23 mm±2.33显著增加到12.48 mm±3.11 (p <;0.001), IFH从20.55 mm±3.40降至24.05 mm±3.78 (p <;0.001),两者均在12个月时显著下降,但此后趋于稳定。临床结果,包括VAS (p = 0.006)和ODI (p = 0.002),与基线相比有显著改善,并持续改善至最新随访。1例患者出现感染,无邻近节段疾病或下沉报告。结论:本研究表明,经后路椎板减压术和椎板间装置(Coflex®)治疗的低级别DLS患者在术后6年的主要放射学参数(包括LL、LL和VT)和脊柱运动方面取得并持续显著改善,且风险或并发症最小。术后观察到IDH和IFH的立即改善,在长期随访中只有轻微的变化。此外,研究结果显示背部疼痛和功能结果有所改善,与基线相比,VAS和ODI评分达到了最小的临床重要差异。FDA设备/药物状态coflex®Interlaminar设备(FDA PMA P110008)(批准用于该适应症)。
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引用次数: 0
13. Association between dynamic instability and muscle health change in patients with L4-5 degenerative Grade I spondylolisthesis and operative spinal stenosis 13. L4-5退行性I级椎体滑脱和椎管狭窄患者的动力不稳定性与肌肉健康变化的关系
Q3 Medicine Pub Date : 2025-07-01 DOI: 10.1016/j.xnsj.2025.100707
Taha Khalilullah BS, Ripul R. Panchal DO, FACS
<div><h3>BACKGROUND CONTEXT</h3><div>Degenerative spondylolisthesis at the L4-5 level is a prevalent spinal condition often requiring surgery. Chronic low back pain has been strongly associated with paraspinal muscle deterioration, including multifidus atrophy, and poorer muscle health has been linked to decreased quality of life. However, the connection between muscle degeneration and lumbar spine instability remains unclear, with contributing factors likely including age, altered biomechanics, and activity levels. Degenerative spondylolisthesis at L4-5 often requires surgery and is linked to paraspinal muscle atrophy and reduced quality of life. However, the impact of instability and alignment changes on muscle health remains unclear, particularly in severe cases. This study aims to address these gaps by investigating muscle health using advanced metrics to better understand its relationship with spondylolisthesis.</div></div><div><h3>PURPOSE</h3><div>This study aims to investigate the association between dynamic instability and muscle health changes in patients with Grade 1 L4-5 degenerative spondylolisthesis and operative spinal stenosis, enhancing our understanding of the pathophysiology of spondylolisthesis.</div></div><div><h3>STUDY DESIGN/SETTING</h3><div>Single-center retrospective cohort study.</div></div><div><h3>PATIENT SAMPLE</h3><div>The study cohort consisted of patients diagnosed with L4-5 spinal stenosis who underwent surgical intervention at the L4-5 level. The cohort was further stratified into two groups: those with L4-5 grade 1 spondylolisthesis and those without spondylolisthesis.</div></div><div><h3>OUTCOME MEASURES</h3><div>Difference in lumbar lordosis, L4-5 Cobb angle, anterior disc height, posterior disc height between flexion and extension, Goutallier classification, lumbar indentation value, BMI, and L4-5 paraspinal and psoas cross sectional area.</div></div><div><h3>METHODS</h3><div>Descriptive statistics were employed to determine L4-5 grade 1 spondylolisthesis, L4-5 spinal stenosis, and surgery involving the L4-5 intervertebral level. Patients were subdivided based on the presence of spondylolisthesis. Cross-sectional area normalized by body mass index (CSA/BMI) was quantified using ImageJ software. Measurement of lumbar lordosis, Cobb angle, and lumbar indentation value were recorded by radiographs. Statistical analysis was conducted using independent Student's t-test and bivariate analysis to compare the groups.</div></div><div><h3>RESULTS</h3><div>There were 101 patients included in our analysis. Fifty-two patients had Grade 1 degenerative spondylolisthesis. The spondylolisthesis group presented with significantly greater L4-5 lordosis in extension compared to the group without spondylolisthesis (23.69 ± 10.62 vs 20.22 ± 7.92, p = .044). However, the spondylolisthesis group also presented with significantly worse anterolisthesis in flexion (7.21 ± 3.66 vs 10.14 ± 23.53, p = .0002). There was no significant diffe
背景:L4-5节段退行性椎体滑脱是一种常见的脊柱疾病,通常需要手术治疗。慢性腰痛与脊柱旁肌肉退化密切相关,包括多裂肌萎缩,而肌肉健康状况较差与生活质量下降有关。然而,肌肉退变与腰椎不稳定之间的关系尚不清楚,可能的影响因素包括年龄、生物力学改变和活动水平。L4-5退行性椎体滑脱通常需要手术,并与棘旁肌萎缩和生活质量下降有关。然而,不稳定和排列变化对肌肉健康的影响尚不清楚,特别是在严重的情况下。本研究旨在通过使用先进的指标来研究肌肉健康,以更好地了解其与脊柱滑脱的关系,从而解决这些差距。目的本研究旨在探讨L4-5级退行性椎体滑脱伴椎管狭窄患者的动力不稳定性与肌肉健康变化的关系,提高我们对椎体滑脱病理生理的认识。研究设计/设置:单中心回顾性队列研究。患者样本:研究队列包括诊断为L4-5椎管狭窄并在L4-5水平行手术干预的患者。该队列进一步分为两组:L4-5级脊柱滑脱组和无脊柱滑脱组。结果测量:腰椎前凸、L4-5 Cobb角、前盘高度、后盘屈伸高度、Goutallier分类、腰椎压痕值、BMI、L4-5棘旁和腰肌横截面积的差异。方法采用描述性统计方法对L4-5级1级椎体滑脱、L4-5级椎管狭窄以及涉及L4-5椎间节段的手术进行统计。根据有无脊柱滑脱对患者进行细分。采用ImageJ软件对体重指数归一化横截面积(CSA/BMI)进行量化。通过x线片测量腰椎前凸、Cobb角和腰椎压痕值。统计学分析采用独立的Student’st检验和双变量分析进行组间比较。结果101例患者纳入我们的分析。52例患者为1级退行性椎体滑脱。与无滑脱组相比,滑脱组L4-5前凸明显增大(23.69±10.62 vs 20.22±7.92,p = .044)。然而,脊柱滑脱组屈曲前滑脱也明显更差(7.21±3.66 vs 10.14±23.53,p = .0002)。两组患者前凸和L4-5节段屈伸角度的绝对差异无统计学意义。通过双变量分析,结果显示腰肌CSA/BMI与腰椎前凸差异呈显著负相关(p = )。0038, r = - 0.578)、Goutallier评分、前凸度和L4-5 Cobb角(p = )。00017, r = .798)。在非脊柱滑脱组中,类似的结果并不显著。结论本研究强调了L4-5退行性椎体滑脱和椎管狭窄患者的动力不稳定性与肌肉健康之间的重要联系。腰椎滑脱患者在伸展时表现出更大的L4-5前凸,在屈曲时表现出更严重的前滑脱,腰肌健康状况与不稳定性指标呈负相关。这些发现表明,肌肉退化可能有助于脊柱滑脱的病理生理,需要进一步的研究来指导靶向治疗。FDA器械/药物状态本摘要不讨论或包括任何适用的器械或药物。
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引用次数: 0
34. Postoperative changes in pelvic indices after MIS-TLIF for lumbar spondylolisthesis: retrospective analysis 34. miss - tlif治疗腰椎滑脱术后骨盆指数的变化:回顾性分析
Q3 Medicine Pub Date : 2025-07-01 DOI: 10.1016/j.xnsj.2025.100728
Shrey Binyala MS, DNB
<div><h3>BACKGROUND CONTEXT</h3><div>Lumbar spondylolisthesis often results in pelvic imbalance, contributing to chronic pain and disability. Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) has emerged as an effective surgical option, offering stabilization and correction of spinal alignment with reduced tissue disruption.</div></div><div><h3>PURPOSE</h3><div>This retrospective study evaluates postoperative improvements in pelvic indices, including pelvic incidence (PI), pelvic tilt (PT), sacral slope (SS), and lumbar lordosis (LL), in patients with lumbar spondylolisthesis treated with MIS-TLIF.</div></div><div><h3>STUDY DESIGN/SETTING</h3><div>The study design is retrospective. It involves reviewing and analyzing the medical records and radiographic data of patients who underwent MIS-TLIF for lumbar spondylolisthesis between 2018 and 2024. The study examines preoperative and postoperative changes in pelvic indices and their correlation with clinical outcomes.</div></div><div><h3>PATIENT SAMPLE</h3><div>A total of 354 patients were included in this retrospective study.</div></div><div><h3>OUTCOME MEASURES</h3><div>Pelvic Indices: PI, PT, SS, LL. Preoperative and postoperative changes in these parameters were assessed through radiographic imaging. Clinical Outcomes: pain levels, assessed using a visual analog scale (VAS) preoperatively and postoperatively. Functional improvements, measured using the Oswestry Disability Index (ODI) or a similar functional assessment tool. Sagittal Alignment: improvement in overall spinal sagittal balance, evaluated through radiographic measurements and clinical examination. Correlation between radiographic and clinical outcomes: The relationship between improvements in pelvic indices and clinical improvements in pain and function was analyzed. Complications: any intraoperative or postoperative complications, such as infection or hardware failure, were documented.</div></div><div><h3>METHODS</h3><div>This is a retrospective study involving patients who underwent MIS-TLIF for lumbar spondylolisthesis between 2018 and 2024. The following steps were involved: Patient Selection: inclusion criteria: patients diagnosed with lumbar spondylolisthesis who underwent MIS-TLIF surgery. Exclusion criteria: patients with incomplete clinical or radiographic data or those who had additional spine surgeries outside the MIS-TLIF approach. Radiographic Analysis: Preoperative and postoperative radiographs (x-rays or CT scans) were reviewed to measure key pelvic parameters, including: PI, PT, SS, LL. Changes in these pelvic indices were analyzed to evaluate improvements in sagittal alignment. Clinical Outcome Assessment: Pain Assessment: pain levels were measured using the VAS preoperatively and at follow-up intervals. Functional Outcome: Functional improvements were assessed using the ODI or other relevant clinical scoring tools. Follow-up: Patients were followed up at regular intervals (eg, 1, 3, and 6 months; 1,
背景:腰椎滑脱常导致骨盆失衡,导致慢性疼痛和残疾。微创经椎间孔腰椎椎体间融合术(MIS-TLIF)已成为一种有效的手术选择,在减少组织破坏的同时稳定和矫正脊柱排列。目的:本回顾性研究评估经MIS-TLIF治疗的腰椎滑脱患者术后骨盆指数的改善,包括骨盆发生率(PI)、骨盆倾斜(PT)、骶骨斜度(SS)和腰椎前凸(LL)。研究设计/设置本研究采用回顾性设计。它涉及审查和分析2018年至2024年间因腰椎滑脱而接受MIS-TLIF的患者的医疗记录和放射学数据。该研究检查了术前和术后盆腔指数的变化及其与临床结果的相关性。本回顾性研究共纳入354例患者。主要指标:PI、PT、SS、LL。术前和术后这些参数的变化通过x线影像进行评估。临床结果:术前和术后用视觉模拟量表(VAS)评估疼痛水平。功能改善,使用Oswestry残疾指数(ODI)或类似的功能评估工具来衡量。矢状位对齐:通过x线测量和临床检查评估脊柱整体矢状位平衡的改善。影像学与临床结果的相关性:分析盆腔指数改善与临床疼痛和功能改善之间的关系。并发症:任何术中或术后并发症,如感染或硬件故障,记录在案。方法本研究是一项回顾性研究,涉及2018年至2024年腰椎滑脱患者。涉及以下步骤:患者选择:纳入标准:诊断为腰椎滑脱并接受MIS-TLIF手术的患者。排除标准:临床或影像学资料不完整的患者或在MIS-TLIF入路之外进行过额外脊柱手术的患者。影像学分析:回顾术前和术后x线片(x线或CT扫描)测量骨盆关键参数,包括:PI, PT, SS, LL。分析这些骨盆指数的变化,以评估矢状位对齐的改善。临床结果评估:疼痛评估:术前和随访期间采用VAS测量疼痛水平。功能结果:使用ODI或其他相关临床评分工具评估功能改善。随访:患者定期随访(如1、3、6个月;1、2和4年)评估临床和影像学结果。统计分析:描述性统计用于总结患者人口统计学、放射学资料和临床结果。采用配对t检验或其他适当的统计检验比较术前和术后盆腔指数和临床评分。评估影像学改善与临床结果(疼痛缓解和功能改善)之间的相关性。并发症:记录并分析任何手术并发症,包括硬件故障、感染或神经损伤。结果术后PT和SS均有明显改善,整体矢状面平衡改善。高度椎体滑脱患者的PI显著改善。患者报告术后疼痛减轻,功能改善。结论smis - tlif可有效恢复腰椎滑脱患者的骨盆参数并改善矢状位。骨盆指数的矫正与增强的临床结果相关,支持MIS-TLIF作为治疗这种疾病的可靠手术方法。FDA器械/药物状态本摘要不讨论或包括任何适用的器械或药物。
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引用次数: 0
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North American Spine Society Journal
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