Pub Date : 2022-01-01Epub Date: 2022-12-15DOI: 10.1007/s43939-022-00033-3
Maria João Oliveira, Ana Dalot, Elvira Fortunato, Rodrigo Martins, Hugh J Byrne, Ricardo Franco, Hugo Águas
A new avenue has opened up for applications of surface-enhanced Raman spectroscopy (SERS) in the biomedical field, mainly due to the striking advantages offered by SERS tags. SERS tags provide indirect identification of analytes with rich and highly specific spectral fingerprint information, high sensitivity, and outstanding multiplexing potential, making them very useful in in vitro and in vivo assays. The recent and innovative advances in nanomaterial science, novel Raman reporters, and emerging bioconjugation protocols have helped develop ultra-bright SERS tags as powerful tools for multiplex SERS-based detection and diagnosis applications. Nevertheless, to translate SERS platforms to real-world problems, some challenges, especially for clinical applications, must be addressed. This review presents the current understanding of the factors influencing the quality of SERS tags and the strategies commonly employed to improve not only spectral quality but the specificity and reproducibility of the interaction of the analyte with the target ligand. It further explores some of the most common approaches which have emerged for coupling SERS with microfluidic technologies, for biomedical applications. The importance of understanding microfluidic production and characterisation to yield excellent device quality while ensuring high throughput production are emphasised and explored, after which, the challenges and approaches developed to fulfil the potential that SERS-based microfluidics have to offer are described.
{"title":"Microfluidic SERS devices: brightening the future of bioanalysis.","authors":"Maria João Oliveira, Ana Dalot, Elvira Fortunato, Rodrigo Martins, Hugh J Byrne, Ricardo Franco, Hugo Águas","doi":"10.1007/s43939-022-00033-3","DOIUrl":"10.1007/s43939-022-00033-3","url":null,"abstract":"<p><p>A new avenue has opened up for applications of surface-enhanced Raman spectroscopy (SERS) in the biomedical field, mainly due to the striking advantages offered by SERS tags. SERS tags provide indirect identification of analytes with rich and highly specific spectral fingerprint information, high sensitivity, and outstanding multiplexing potential, making them very useful in in vitro and in vivo assays. The recent and innovative advances in nanomaterial science, novel Raman reporters, and emerging bioconjugation protocols have helped develop ultra-bright SERS tags as powerful tools for multiplex SERS-based detection and diagnosis applications. Nevertheless, to translate SERS platforms to real-world problems, some challenges, especially for clinical applications, must be addressed. This review presents the current understanding of the factors influencing the quality of SERS tags and the strategies commonly employed to improve not only spectral quality but the specificity and reproducibility of the interaction of the analyte with the target ligand. It further explores some of the most common approaches which have emerged for coupling SERS with microfluidic technologies, for biomedical applications. The importance of understanding microfluidic production and characterisation to yield excellent device quality while ensuring high throughput production are emphasised and explored, after which, the challenges and approaches developed to fulfil the potential that SERS-based microfluidics have to offer are described.</p>","PeriodicalId":34625,"journal":{"name":"Discover Materials","volume":"2 1","pages":"12"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10402049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.1007/s43939-021-00021-z
N. Kröger, E. Brunner, L. Estroff, F. Marin
{"title":"The role of organic matrices in biomineralization","authors":"N. Kröger, E. Brunner, L. Estroff, F. Marin","doi":"10.1007/s43939-021-00021-z","DOIUrl":"https://doi.org/10.1007/s43939-021-00021-z","url":null,"abstract":"","PeriodicalId":34625,"journal":{"name":"Discover Materials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47111041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.1007/s43939-021-00020-0
C. Thambiliyagodage, R. Wijesekera, M. Bakker
{"title":"Leaching of ilmenite to produce titanium based materials: a review","authors":"C. Thambiliyagodage, R. Wijesekera, M. Bakker","doi":"10.1007/s43939-021-00020-0","DOIUrl":"https://doi.org/10.1007/s43939-021-00020-0","url":null,"abstract":"","PeriodicalId":34625,"journal":{"name":"Discover Materials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44049306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-16DOI: 10.1007/s43939-021-00018-8
R. Manchester, T. Todorova, E. Tonkopi, B. Kelly, J. Gosse, C. Davis, Kimberly D. Brewer, M. Shymka, Daniel Boyd
{"title":"Dissolution behaviour and imageability of ternary borate glasses for use in geniculate artery embolization","authors":"R. Manchester, T. Todorova, E. Tonkopi, B. Kelly, J. Gosse, C. Davis, Kimberly D. Brewer, M. Shymka, Daniel Boyd","doi":"10.1007/s43939-021-00018-8","DOIUrl":"https://doi.org/10.1007/s43939-021-00018-8","url":null,"abstract":"","PeriodicalId":34625,"journal":{"name":"Discover Materials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46671895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-10DOI: 10.1007/s43939-021-00015-x
Júlia Chaumel, Maria Marsal, Adrián Gómez-Sánchez, M. Blumer, E. Gualda, A. de Juan, P. Loza-Álvarez, M. Dean
{"title":"Autofluorescence of stingray skeletal cartilage: hyperspectral imaging as a tool for histological characterization","authors":"Júlia Chaumel, Maria Marsal, Adrián Gómez-Sánchez, M. Blumer, E. Gualda, A. de Juan, P. Loza-Álvarez, M. Dean","doi":"10.1007/s43939-021-00015-x","DOIUrl":"https://doi.org/10.1007/s43939-021-00015-x","url":null,"abstract":"","PeriodicalId":34625,"journal":{"name":"Discover Materials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s43939-021-00015-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49039902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-25DOI: 10.1007/s43939-021-00016-w
B. Zaidi, C. Shekhar, B. Hadjoudja, S. Gagui, S. Zahra, M. A. Saeed
{"title":"Simulation study of monolithic MoSe2/CIGS tandem solar cells","authors":"B. Zaidi, C. Shekhar, B. Hadjoudja, S. Gagui, S. Zahra, M. A. Saeed","doi":"10.1007/s43939-021-00016-w","DOIUrl":"https://doi.org/10.1007/s43939-021-00016-w","url":null,"abstract":"","PeriodicalId":34625,"journal":{"name":"Discover Materials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s43939-021-00016-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48874252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-10DOI: 10.1007/s43939-021-00013-z
S. Joffre, P. DeYoung, J. R. Hampton
{"title":"Comparing electrochemical analysis and particle induced X-ray emission measurements of Prussian Blue Analogue deposits","authors":"S. Joffre, P. DeYoung, J. R. Hampton","doi":"10.1007/s43939-021-00013-z","DOIUrl":"https://doi.org/10.1007/s43939-021-00013-z","url":null,"abstract":"","PeriodicalId":34625,"journal":{"name":"Discover Materials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s43939-021-00013-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42348639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-29DOI: 10.1007/s43939-021-00017-9
Friedrich von Hoessle, Reham Farid, Mayar Mohamed, R. Hammouda, F. E. Kühn, G. Bassioni
{"title":"The effect of different hydration media on magnesia","authors":"Friedrich von Hoessle, Reham Farid, Mayar Mohamed, R. Hammouda, F. E. Kühn, G. Bassioni","doi":"10.1007/s43939-021-00017-9","DOIUrl":"https://doi.org/10.1007/s43939-021-00017-9","url":null,"abstract":"","PeriodicalId":34625,"journal":{"name":"Discover Materials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44067236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-08DOI: 10.1007/s43939-021-00011-1
Adeeba Fathima, C. A. Quintana-Cataño, Christoph Heintze, M. Schlierf
{"title":"Precision of fiducial marker alignment for correlative super‐resolution fluorescence and transmission electron microscopy","authors":"Adeeba Fathima, C. A. Quintana-Cataño, Christoph Heintze, M. Schlierf","doi":"10.1007/s43939-021-00011-1","DOIUrl":"https://doi.org/10.1007/s43939-021-00011-1","url":null,"abstract":"","PeriodicalId":34625,"journal":{"name":"Discover Materials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s43939-021-00011-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42678227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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