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Pickleball-Related Geriatric Fractures and Pediatric Equipment-Related Injuries Are Increasing in Emergency Departments Across the United States 匹克球相关的老年人骨折和儿科设备相关的伤害在美国各地的急诊科正在增加
Q3 Medicine Pub Date : 2025-10-01 DOI: 10.1016/j.asmr.2025.101228
Philip M. Lee B.S. , Ryan Nishi B.S. , Kyle K. Obana M.D. , Sean M. Chan M.D. , Jae K. You M.D. , Jennifer M. Weiss M.D. , William N. Levine M.D. , David P. Trofa M.D.

Purpose

To evaluate the epidemiology, prevalence, and mechanism of injury of pickleball-related injuries in patients presenting to emergency departments in the United States.

Methods

Data between 2004 and 2023 from the National Electronic Injury Surveillance System were analyzed for racquetball-related injuries. The data set was screened for pickleball-related injuries using keywords. Data included body part, diagnosis, mechanism of injury, and disposition. Calculations used corresponding hospital sample weights for national estimates (NEs). Patients were divided into the following age groups: pediatric (<18 years), 19 to 39 years, 40 to 59 years, and 60 years or older.

Results

A total of 1,714 injuries (NE, 99,816 [98.8%]) were included. The most commonly injured body locations were the upper trunk (n = 232) (NE, 14,884 [13.5%]), head (n = 226) (NE, 12,990 [13.2%]), and knee (n = 188) (NE, 10,700 [10.9%]). The most identified final diagnoses were fracture (n = 493) (NE, 27,493 [28.7%]), sprain/strain (n = 423) (NE, 25,237 [24.7%]), internal organ damage (n = 168) (NE, 10,050 [9.8%]), and contusion (n = 163) (NE, 9,573 [9.5%]). The most identified mechanisms of injury were impact with the floor (n = 856) (NE, 50,797 [49.9%]), exertional cardiovascular event (n = 244) (NE, 15,796 [14.2%]), and non-contact movement (n = 222) (NE, 12,936 [13.0%]). Pediatric patients had the highest proportion of head injuries (NE, 222 [16.9%]) and injuries from equipment (NE, 634 [32.2%]). The group aged 60 years or older had the highest proportion of wrist injuries (NE, 10,302 [13.0%]), fractures (NE, 17,802 [32.8%]), and injuries cause by impact with the floor (NE, 43,592 [56.1%]). Additionally, this group had the highest proportion of upper trunk injuries (NE, 12,947 [15.4%]) and exertional chest pain (NE, 13,789 [16.2%]).

Conclusions

Pickleball injuries most frequently involved the upper trunk, head, and knee, with fractures and sprains/strains being the most common diagnoses. Nearly half of all pickleball injuries resulted from impacts with the floor. Pediatric patients had a higher proportion of head injuries and equipment-related trauma, whereas older adults (≥60 years) were more prone to wrist and upper trunk injuries, fractures, and exertional chest pain.

Level of Evidence

Level IV, retrospective epidemiologic case series.
目的评估美国急诊患者匹克球相关损伤的流行病学、患病率和损伤机制。方法分析2004 - 2023年国家电子伤害监测系统中与壁球相关的伤害数据。数据集使用关键词筛选匹克球相关损伤。资料包括身体部位、诊断、损伤机制和处置。计算使用相应的医院样本权重进行国家估计(NEs)。患者分为以下年龄组:儿科(18岁)、19至39岁、40至59岁和60岁及以上。结果共纳入损伤1,714例,其中NE 99,816例(98.8%)。最常见的身体损伤部位为上躯干(n = 232) (NE, 14,884[13.5%])、头部(n = 226) (NE, 12,990[13.2%])和膝关节(n = 188) (NE, 10,700[10.9%])。最常见的最终诊断为骨折(n = 493) (NE, 27,493[28.7%]),扭伤/拉伤(n = 423) (NE, 25,237[24.7%]),内脏器官损伤(n = 168) (NE, 10,050[9.8%])和挫伤(n = 163) (NE, 9,573[9.5%])。最明确的损伤机制是撞击地板(n = 856) (NE, 50,797[49.9%]),用力性心血管事件(n = 244) (NE, 15,796[14.2%])和非接触性运动(n = 222) (NE, 12,936[13.0%])。儿科患者的头部损伤比例最高(NE, 222例[16.9%]),设备损伤比例最高(NE, 634例[32.2%])。60岁及以上年龄组腕部损伤(NE, 10,302例[13.0%])、骨折(NE, 17,802例[32.8%])和撞击地板损伤(NE, 43,592例[56.1%])所占比例最高。此外,该组上干损伤比例最高(NE, 12,947例[15.4%]),运动性胸痛比例最高(NE, 13,789例[16.2%])。结论匹克球损伤多见于上肢、头部和膝关节,骨折和扭伤/拉伤是最常见的诊断。几乎一半的匹克球损伤是由于撞击地板造成的。儿科患者有较高比例的头部损伤和器械相关创伤,而老年人(≥60岁)更容易发生手腕和上肢损伤、骨折和运动性胸痛。证据水平:IV级,回顾性流行病学病例系列。
{"title":"Pickleball-Related Geriatric Fractures and Pediatric Equipment-Related Injuries Are Increasing in Emergency Departments Across the United States","authors":"Philip M. Lee B.S. ,&nbsp;Ryan Nishi B.S. ,&nbsp;Kyle K. Obana M.D. ,&nbsp;Sean M. Chan M.D. ,&nbsp;Jae K. You M.D. ,&nbsp;Jennifer M. Weiss M.D. ,&nbsp;William N. Levine M.D. ,&nbsp;David P. Trofa M.D.","doi":"10.1016/j.asmr.2025.101228","DOIUrl":"10.1016/j.asmr.2025.101228","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the epidemiology, prevalence, and mechanism of injury of pickleball-related injuries in patients presenting to emergency departments in the United States.</div></div><div><h3>Methods</h3><div>Data between 2004 and 2023 from the National Electronic Injury Surveillance System were analyzed for racquetball-related injuries. The data set was screened for pickleball-related injuries using keywords. Data included body part, diagnosis, mechanism of injury, and disposition. Calculations used corresponding hospital sample weights for national estimates (NEs). Patients were divided into the following age groups: pediatric (&lt;18 years), 19 to 39 years, 40 to 59 years, and 60 years or older.</div></div><div><h3>Results</h3><div>A total of 1,714 injuries (NE, 99,816 [98.8%]) were included. The most commonly injured body locations were the upper trunk (n = 232) (NE, 14,884 [13.5%]), head (n = 226) (NE, 12,990 [13.2%]), and knee (n = 188) (NE, 10,700 [10.9%]). The most identified final diagnoses were fracture (n = 493) (NE, 27,493 [28.7%]), sprain/strain (n = 423) (NE, 25,237 [24.7%]), internal organ damage (n = 168) (NE, 10,050 [9.8%]), and contusion (n = 163) (NE, 9,573 [9.5%]). The most identified mechanisms of injury were impact with the floor (n = 856) (NE, 50,797 [49.9%]), exertional cardiovascular event (n = 244) (NE, 15,796 [14.2%]), and non-contact movement (n = 222) (NE, 12,936 [13.0%]). Pediatric patients had the highest proportion of head injuries (NE, 222 [16.9%]) and injuries from equipment (NE, 634 [32.2%]). The group aged 60 years or older had the highest proportion of wrist injuries (NE, 10,302 [13.0%]), fractures (NE, 17,802 [32.8%]), and injuries cause by impact with the floor (NE, 43,592 [56.1%]). Additionally, this group had the highest proportion of upper trunk injuries (NE, 12,947 [15.4%]) and exertional chest pain (NE, 13,789 [16.2%]).</div></div><div><h3>Conclusions</h3><div>Pickleball injuries most frequently involved the upper trunk, head, and knee, with fractures and sprains/strains being the most common diagnoses. Nearly half of all pickleball injuries resulted from impacts with the floor. Pediatric patients had a higher proportion of head injuries and equipment-related trauma, whereas older adults (≥60 years) were more prone to wrist and upper trunk injuries, fractures, and exertional chest pain.</div></div><div><h3>Level of Evidence</h3><div>Level IV, retrospective epidemiologic case series.</div></div>","PeriodicalId":34631,"journal":{"name":"Arthroscopy Sports Medicine and Rehabilitation","volume":"7 5","pages":"Article 101228"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145478976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current Classification Systems for Knee Ligament Injuries Are Limited to Ligament Involvement and Do Not Consider Injury Mechanism or Sequence of Injury: A Scoping Review 当前膝关节韧带损伤的分类系统仅限于韧带受累程度,而不考虑损伤机制或损伤顺序:一项范围综述
Q3 Medicine Pub Date : 2025-10-01 DOI: 10.1016/j.asmr.2025.101207
Jelle P. van der List M.D., Ph.D., M.B.A. , Roy A.G. Hoogeslag M.D., Ph.D.

Purpose

To systematically assess published classification systems for knee ligament injuries and to propose a comprehensive, multiplanar, sequential knee ligament classification system that improves upon those in the published literature.

Methods

The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. PubMed, Embase, and Cochrane were searched from inception to January 2025 for studies reporting knee classification systems. Inclusion criteria consisted of studies reporting knee classification systems and English language. Exclusion criteria consisted of classifications only describing specific type of knee injuries (e.g., only anterior cruciate ligament injuries). The characteristics of each classification system were recorded and analyzed descriptively. A classification system was proposed that addresses the weaknesses of the existing systems.

Results

A total of 6 classification systems were identified in 8 studies in the literature and were published between 1975 and 2009. Existing classification systems were strong in correlating type of injuries with rotatory ligamentous laxity and physical examination findings but were lacking assessment of knee position during injury, discussion of sequence of injuries, involvement of bone marrow edema (except one study), and lack of correlation with knee dislocations. No clinical validation was performed. A knee classification system was created that included sequence of injuries, correlation with knee dislocation and injury mechanism, and bone marrow edema.

Conclusions

Knee injury classification systems lack comprehensive consideration of injury mechanism, sequence of injury, bone marrow edema, meniscus and chondral damage, involved ligaments, rotatory instability, and correlation with knee dislocation. The sequence of injury to these structures could be relevant to understanding injury mechanism and treatment, but requires validation.

Level of Evidence

Level V, systematic review of level IV-V studies.
目的系统评估已发表的膝关节韧带损伤分类系统,并在已有文献的基础上提出一个全面、多平面、顺序的膝关节韧带分类系统。方法遵循系统评价和meta分析指南的首选报告项目。检索PubMed、Embase和Cochrane从成立到2025年1月报道膝关节分类系统的研究。纳入标准包括报道膝关节分类系统和英语语言的研究。排除标准包括仅描述特定类型膝关节损伤的分类(例如,仅前交叉韧带损伤)。对各分类体系的特征进行了记录和描述性分析。针对现有分类系统的不足,提出了一种分类系统。结果1975 - 2009年间发表的8篇文献研究共鉴定出6个分类体系。现有的分类系统在损伤类型与旋转韧带松弛和体格检查结果之间的相关性很强,但缺乏对损伤时膝关节位置的评估、损伤顺序的讨论、骨髓水肿的累及(除一项研究外),以及与膝关节脱位的相关性。没有进行临床验证。建立了膝关节分类系统,包括损伤顺序、与膝关节脱位和损伤机制的相关性以及骨髓水肿。结论膝关节损伤分类系统缺乏综合考虑损伤机制、损伤顺序、骨髓水肿、半月板和软骨损伤、累及韧带、旋转不稳定以及与膝关节脱位的相关性。这些结构的损伤顺序可能与了解损伤机制和治疗有关,但需要验证。证据水平:V级,IV-V级研究的系统评价。
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引用次数: 0
Concomitant Hip Arthroscopy Is Associated With Improved Outcomes of Core Decompression for Osteonecrosis of the Femoral Head: A Systematic Review 联合髋关节镜与股骨头骨坏死核心减压的改善结果相关:一项系统综述
Q3 Medicine Pub Date : 2025-10-01 DOI: 10.1016/j.asmr.2025.101225
Ady H. Kahana-Rojkind M.D. , Paras P. Shah B.A. , Krishi Rana B.A. , Nils Becker M.D. , Roger Quesada-Jimenez M.D. , Benjamin G. Domb M.D.

Purpose

To evaluate the effectiveness of core decompression (CD) with concomitant arthroscopic treatment of intra-articular pathologies for improving outcomes for patients with osteonecrosis of the femoral head (ONFH) and intra-articular pathology and to compare results with patients undergoing isolated CD.

Methods

A systematic literature review was conducted using PubMed, MEDLINE, and Cochrane Library databases through July 2024, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies comparing CD with and without hip arthroscopy (HA) were included, provided they reported patient-reported outcomes (PROs), survivorship, or total hip arthroplasty (THA) conversion rates. Studies were excluded if HA was solely diagnostic. Quality was assessed using Methodological Index for Non-Randomized Studies and Risk Of Bias In Non-randomised Studies - of Interventions. Data extracted included demographics, surgical techniques, PROs, and THA-free survivorship.

Results

Six studies (4 Level III, 2 Level IV) met the inclusion criteria, comprising 632 hips with mean ages ranging from 35.5 to 41.1 years. All studies reported pre- and postoperative Harris Hip Score, and one included visual analog scale pain scores. Patients undergoing CD with HA had significantly greater postoperative Harris Hip Score (71.41-93.33) and improved THA-free survivorship compared with CD alone. Three of four comparative studies showed significantly lower THA conversion rates and femoral head collapse in the HA group. However, no study directly showed that HA improved bone healing.

Conclusions

CD with HA results in better PROs and femoral head survivorship compared with CD alone, likely because of intra-articular pathology treatment and improved joint function. Core decompression with concomitant hip arthroscopy to address intra-articular pathology should be considered for pre-collapse ONFH.

Level of Evidence

Level IV, systematic review of Level III and IV studies.
目的评价骨芯减压(CD)联合关节镜治疗关节内病变对改善股骨头坏死(ONFH)患者预后和关节内病变的效果,并与单纯CD治疗患者的结果进行比较。方法采用PubMed、MEDLINE和Cochrane图书馆数据库进行系统文献综述,截止2024年7月。遵循系统评价和荟萃分析指南的首选报告项目。比较CD与不进行髋关节镜检查(HA)的研究被纳入,前提是他们报告了患者报告的结果(PROs)、生存率或全髋关节置换术(THA)转换率。如果HA仅是诊断性的,则排除研究。使用非随机研究的方法学指数和干预措施的非随机研究的偏倚风险来评估质量。提取的数据包括人口统计学、手术技术、PROs和无tha生存率。结果6项研究(4项III级研究,2项IV级研究)符合纳入标准,包括632例髋关节,平均年龄35.5 ~ 41.1岁。所有研究报告了术前和术后Harris髋关节评分,其中一项包括视觉模拟疼痛评分。与单独CD相比,接受CD合并HA的患者术后Harris髋关节评分(71.41-93.33)显著提高,无tha生存率显著提高。4个比较研究中有3个显示HA组THA转换率和股骨头塌陷明显降低。然而,没有研究直接表明透明质酸能促进骨愈合。结论与单纯CD相比,HA合并scd具有更好的pro和股骨头存活率,这可能与关节内病理治疗和关节功能改善有关。对于塌陷前的ONFH,应考虑椎体减压合并髋关节镜检查以解决关节内病理问题。证据水平:IV级,III级和IV级研究的系统评价。
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引用次数: 0
Femoral Neck Impingement Cysts Treated With Biocomposite Implants in the Setting of Femoroacetabular Impingement Show Improvement in Patient-Reported Outcomes at a Minimum 2-Year Follow-Up 在至少2年的随访中,生物复合植入物治疗股骨颈撞击囊肿在股骨髋臼撞击患者报告的结果中显示出改善
Q3 Medicine Pub Date : 2025-10-01 DOI: 10.1016/j.asmr.2025.101221
Tyler Uppstrom M.D. , Nicholas A. Felan B.A. , Kent C. Doan M.D. , Hannah K. Day M.S. , Spencer M. Comfort B.S. , Trevor J. Shelton M.D. , Grant J. Dornan M.S. , Alyson Speshock M.P.H. , Marc J. Philippon M.D.

Purpose

To assess minimum 2-year outcomes in patients treated with biocomposite anchors for impingement cysts of the femoral neck during hip arthroscopy for femoroacetabular impingement.

Methods

Patients aged 18 to 65 years who underwent treatment of a femoral neck impingement cyst with placement of a suture anchor by the senior surgeon between January 1, 2007, and December 1, 2019, and were eligible for a minimum 2-year follow-up were identified. Demographic, surgical, and patient-reported outcomes—including Hip Outcome Score–Activities of Daily Living (HOS-ADL), Hip Outcome Score–Sport (HOS-SSS), modified Harris Hip Score (mHHS), patient satisfaction, and Tegner Activity Scale—were retrospectively reviewed from the senior surgeon’s prospectively collected database. Complications, including femoral neck fracture, need for revision, or conversion to total hip arthroplasty, were assessed from patient charts and postoperative follow-up surveys. Postoperative magnetic resonance images were assessed for suture anchor integration and presence of a residual cyst.

Results

Fifty patients (50 hips) met inclusion criteria, with a median age at surgery of 45 (range, 19-63) years. Minimum 2-year follow-up was obtained for 43 of 50 (86%) patients, with a mean follow-up time of 3.4 ± 1.4 years. One patient reported conversion to total hip arthroplasty, and no additional patients reported revision surgery or postoperative femoral neck fractures. HOS-ADL, HOS-SSS, mHHS, Western Ontario and McMaster Universities Osteoarthritis Index, and Short Form 12 Physical Component Summary scores significantly improved after hip arthroscopy (P < .001), with most patients attaining minimum clinically significant difference and patient acceptable symptom state for HOS-ADL, HOS-SSS, and mHHS. Notably, the median postoperative patient satisfaction score was 9.0 of 10 (range, 1-10).

Conclusions

Hips with femoral neck impingement cysts treated with biocomposite suture anchors showed excellent patient-reported outcomes and high survivorship at a minimum 2-year follow-up, with most patients achieving mHHS minimum clinically significant difference and patient acceptable symptom state.

Level of Evidence

Level IV, retrospective therapeutic case series.
目的评估在股骨髋臼撞击患者髋关节镜下应用生物复合锚钉治疗股骨颈撞击囊肿至少2年的疗效。方法选取2007年1月1日至2019年12月1日期间由资深外科医生行股骨颈撞击囊肿缝合锚钉置入治疗的患者,年龄18 ~ 65岁,符合至少2年随访条件。从资深外科医生前瞻性收集的数据库中回顾性回顾了人口统计学、外科手术和患者报告的结果,包括髋关节结局评分-日常生活活动(HOS-ADL)、髋关节结局评分-运动(HOS-SSS)、改良Harris髋关节评分(mHHS)、患者满意度和Tegner活动量表。并发症,包括股骨颈骨折,需要翻修,或转换为全髋关节置换术,从患者图表和术后随访调查中进行评估。术后磁共振图像评估缝合锚整合和残余囊肿的存在。结果50例患者(50髋)符合纳入标准,手术时中位年龄45岁(范围19-63岁)。50例患者中有43例(86%)获得至少2年随访,平均随访时间为3.4±1.4年。1例患者报告了全髋关节置换术,没有其他患者报告了翻修手术或术后股骨颈骨折。髋关节镜检查后,HOS-ADL、HOS-SSS、mHHS、Western Ontario and McMaster Universities Osteoarthritis Index、Short Form 12 Physical Component Summary评分均显著改善(P < .001),多数患者在HOS-ADL、HOS-SSS、mHHS方面达到最小的临床显著差异和患者可接受的症状状态。值得注意的是,术后患者满意度中位数为9.0分(范围1-10)。结论在至少2年的随访中,生物复合缝合锚钉治疗股骨颈撞击囊肿具有良好的患者报告结果和高生存率,大多数患者达到mHHS最低临床显著差异和患者可接受的症状状态。证据水平:IV级,回顾性治疗病例系列。
{"title":"Femoral Neck Impingement Cysts Treated With Biocomposite Implants in the Setting of Femoroacetabular Impingement Show Improvement in Patient-Reported Outcomes at a Minimum 2-Year Follow-Up","authors":"Tyler Uppstrom M.D. ,&nbsp;Nicholas A. Felan B.A. ,&nbsp;Kent C. Doan M.D. ,&nbsp;Hannah K. Day M.S. ,&nbsp;Spencer M. Comfort B.S. ,&nbsp;Trevor J. Shelton M.D. ,&nbsp;Grant J. Dornan M.S. ,&nbsp;Alyson Speshock M.P.H. ,&nbsp;Marc J. Philippon M.D.","doi":"10.1016/j.asmr.2025.101221","DOIUrl":"10.1016/j.asmr.2025.101221","url":null,"abstract":"<div><h3>Purpose</h3><div>To assess minimum 2-year outcomes in patients treated with biocomposite anchors for impingement cysts of the femoral neck during hip arthroscopy for femoroacetabular impingement.</div></div><div><h3>Methods</h3><div>Patients aged 18 to 65 years who underwent treatment of a femoral neck impingement cyst with placement of a suture anchor by the senior surgeon between January 1, 2007, and December 1, 2019, and were eligible for a minimum 2-year follow-up were identified. Demographic, surgical, and patient-reported outcomes—including Hip Outcome Score–Activities of Daily Living (HOS-ADL), Hip Outcome Score–Sport (HOS-SSS), modified Harris Hip Score (mHHS), patient satisfaction, and Tegner Activity Scale—were retrospectively reviewed from the senior surgeon’s prospectively collected database. Complications, including femoral neck fracture, need for revision, or conversion to total hip arthroplasty, were assessed from patient charts and postoperative follow-up surveys. Postoperative magnetic resonance images were assessed for suture anchor integration and presence of a residual cyst.</div></div><div><h3>Results</h3><div>Fifty patients (50 hips) met inclusion criteria, with a median age at surgery of 45 (range, 19-63) years. Minimum 2-year follow-up was obtained for 43 of 50 (86%) patients, with a mean follow-up time of 3.4 ± 1.4 years. One patient reported conversion to total hip arthroplasty, and no additional patients reported revision surgery or postoperative femoral neck fractures. HOS-ADL, HOS-SSS, mHHS, Western Ontario and McMaster Universities Osteoarthritis Index, and Short Form 12 Physical Component Summary scores significantly improved after hip arthroscopy (<em>P</em> &lt; .001), with most patients attaining minimum clinically significant difference and patient acceptable symptom state for HOS-ADL, HOS-SSS, and mHHS. Notably, the median postoperative patient satisfaction score was 9.0 of 10 (range, 1-10).</div></div><div><h3>Conclusions</h3><div>Hips with femoral neck impingement cysts treated with biocomposite suture anchors showed excellent patient-reported outcomes and high survivorship at a minimum 2-year follow-up, with most patients achieving mHHS minimum clinically significant difference and patient acceptable symptom state.</div></div><div><h3>Level of Evidence</h3><div>Level IV, retrospective therapeutic case series.</div></div>","PeriodicalId":34631,"journal":{"name":"Arthroscopy Sports Medicine and Rehabilitation","volume":"7 5","pages":"Article 101221"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145479047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacterial Analysis of Hamstring Autograft With Vancomycin Presoaking in Primary Anterior Cruciate Ligament Reconstruction Shows High Incidence of Colonization Without Early Clinical Infection 万古霉素预浸自体腘绳肌腱前交叉韧带重建术细菌分析显示,无早期临床感染的自体腘绳肌腱移植物定植率高
Q3 Medicine Pub Date : 2025-10-01 DOI: 10.1016/j.asmr.2025.101231
Maximiliano Scheu M.D. , Raimundo Bosselin M.D. , Rafael Araos M.D. , Juan Ugalde M.D. , María Jesús Tuca M.D. , Gonzalo Espinoza M.D.

Purpose

To determine the incidence of autograft bacterial colonization (BC) in anterior cruciate ligament reconstruction (ACLR) and to identify any bacteria type at the genus level.

Methods

This prospective descriptive study included patients aged 18 years or older undergoing ACLR with hamstring autograft. Thirty-one patients (21 male and 10 female patients), with a mean age of 32.2 years, were included, with a mean follow-up period of 150 days (range, 90-208 days). Three samples were taken from every surgical procedure: a sample from the graft at the time it was obtained, a sample from the graft after tibial fixation, and a sample from the saline solution receptacle on the instrument table (control). All grafts underwent vancomycin presoaking. Bacterial composition was determined by next-generation sequencing of the 16S ribosomal RNA coding gene. Descriptive statistics were used to summarize data. The Fisher exact test was used to compare group samples (with P < .05 considered significant).

Results

BC was detected in 11 of 31 patients (35.4%). BC was found in the first sample (sample from the graft at the time it was obtained) in 1 patient and in the third sample (control) in another. All 11 patients showed BC in the second sample (sample from the graft after tibial fixation), with statistical significance (P = .003). In these samples with BC, 47 types of gram-negative bacteria (GNB) were identified, averaging 6.8 bacteria per sample, with 3.97% relative abundance per bacterium. Pseudomonas was present in 5 of 11 samples, with 6.76% relative abundance. Additionally, 33 types of gram-positive bacteria (GPB) were found, averaging 6 bacteria per sample, with 9.62% relative abundance per bacterium; Streptococcus was present in 8 of 11 samples, with 26.23% relative abundance. All colonized samples exhibited both GPB and GNB.

Conclusions

Bacterial contamination during ACLR is frequent, with the presence of both GNB and GPB. Although such colonization was common, no early clinical infections were noted in our patient cohort.

Level of Evidence

Level III, prospective descriptive study.
目的了解前交叉韧带重建(ACLR)中自体移植物细菌定植(BC)的发生率,并在属水平上鉴定细菌类型。方法本前瞻性描述性研究纳入18岁及以上行ACLR合并自体腘绳肌移植的患者。纳入31例患者(男21例,女10例),平均年龄32.2岁,平均随访时间150天(范围90 ~ 208天)。每次手术均取三份样本:取植骨时的样本,胫骨固定后的样本,以及手术台上生理盐水容器的样本(对照组)。所有移植物均进行万古霉素预处理。通过下一代16S核糖体RNA编码基因测序确定细菌组成。采用描述性统计对数据进行汇总。采用Fisher精确检验比较各组样本(P <; 0.05认为显著)。结果31例患者中11例(35.4%)检出bc。1例患者的第一个样本(获得移植物时的样本)中发现了BC,另1例患者的第三个样本(对照)中发现了BC。11例患者在第二份样本(胫骨固定后的移植物样本)中均出现BC,差异有统计学意义(P = 0.003)。在这些带有BC的样本中,鉴定出47种革兰氏阴性菌(GNB),平均每个样本6.8个细菌,每个细菌的相对丰度为3.97%。11份样品中有5份检出假单胞菌,相对丰度为6.76%。革兰氏阳性菌(GPB) 33种,平均6株,相对丰度为9.62%;11份样品中有8份存在链球菌,相对丰度为26.23%。所有定植样品均显示GPB和GNB。结论ACLR过程中细菌污染较为频繁,GNB和GPB均存在。虽然这种定植很常见,但在我们的患者队列中没有发现早期临床感染。证据等级:III级,前瞻性描述性研究。
{"title":"Bacterial Analysis of Hamstring Autograft With Vancomycin Presoaking in Primary Anterior Cruciate Ligament Reconstruction Shows High Incidence of Colonization Without Early Clinical Infection","authors":"Maximiliano Scheu M.D. ,&nbsp;Raimundo Bosselin M.D. ,&nbsp;Rafael Araos M.D. ,&nbsp;Juan Ugalde M.D. ,&nbsp;María Jesús Tuca M.D. ,&nbsp;Gonzalo Espinoza M.D.","doi":"10.1016/j.asmr.2025.101231","DOIUrl":"10.1016/j.asmr.2025.101231","url":null,"abstract":"<div><h3>Purpose</h3><div>To determine the incidence of autograft bacterial colonization (BC) in anterior cruciate ligament reconstruction (ACLR) and to identify any bacteria type at the genus level.</div></div><div><h3>Methods</h3><div>This prospective descriptive study included patients aged 18 years or older undergoing ACLR with hamstring autograft. Thirty-one patients (21 male and 10 female patients), with a mean age of 32.2 years, were included, with a mean follow-up period of 150 days (range, 90-208 days). Three samples were taken from every surgical procedure: a sample from the graft at the time it was obtained, a sample from the graft after tibial fixation, and a sample from the saline solution receptacle on the instrument table (control). All grafts underwent vancomycin presoaking. Bacterial composition was determined by next-generation sequencing of the 16S ribosomal RNA coding gene. Descriptive statistics were used to summarize data. The Fisher exact test was used to compare group samples (with <em>P</em> &lt; .05 considered significant).</div></div><div><h3>Results</h3><div>BC was detected in 11 of 31 patients (35.4%). BC was found in the first sample (sample from the graft at the time it was obtained) in 1 patient and in the third sample (control) in another. All 11 patients showed BC in the second sample (sample from the graft after tibial fixation), with statistical significance (<em>P</em> = .003). In these samples with BC, 47 types of gram-negative bacteria (GNB) were identified, averaging 6.8 bacteria per sample, with 3.97% relative abundance per bacterium. <em>Pseudomonas</em> was present in 5 of 11 samples, with 6.76% relative abundance. Additionally, 33 types of gram-positive bacteria (GPB) were found, averaging 6 bacteria per sample, with 9.62% relative abundance per bacterium; <em>Streptococcus</em> was present in 8 of 11 samples, with 26.23% relative abundance. All colonized samples exhibited both GPB and GNB.</div></div><div><h3>Conclusions</h3><div>Bacterial contamination during ACLR is frequent, with the presence of both GNB and GPB. Although such colonization was common, no early clinical infections were noted in our patient cohort.</div></div><div><h3>Level of Evidence</h3><div>Level III, prospective descriptive study.</div></div>","PeriodicalId":34631,"journal":{"name":"Arthroscopy Sports Medicine and Rehabilitation","volume":"7 5","pages":"Article 101231"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145478916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ChatGPT Can Provide Satisfactory Answers to Assessments of Mock Clinical Photos Following Anterior Cruciate Ligament Reconstruction and Rotator Cuff Repair ChatGPT可以为前交叉韧带重建和肩袖修复后的模拟临床照片评估提供满意的答案
Q3 Medicine Pub Date : 2025-10-01 DOI: 10.1016/j.asmr.2025.101212
Ian Hollyer M.D., Grant G. Schroeder M.D., Bill Young B.S., Connor Sholtis M.D., Anastasia Hunt M.D., Jayme Koltsov Ph.D., Seth L. Sherman M.D., Marc R. Safran M.D.

Purpose

To evaluate the ability of ChatGPT-4o to provide clinical assessments of mock photos of knees and shoulders that had undergone arthroscopic or open surgery and answer common questions related to anterior cruciate ligament reconstruction and rotator cuff repair.

Methods

The authors created a series of mock postoperative knee and shoulder photos and common questions about anterior cruciate ligament reconstruction and rotator cuff repair. These clinical photos and questions were presented to GPT in isolated chat windows and without prior training, and its responses were graded by orthopaedic surgeons, physician assistants, and residents using a previously established 4-point grading system.

Results

When grading ChatGPT’s assessments of mock clinical photos, raters gave 18.8% to 75.0% total excellent grades and 0% to 25.0% unsatisfactory grades. When grading ChatGPT question answers, raters gave 4.5% to 77.3% total excellent grades and 0% to 9.1% unsatisfactory grades. Mean grades ranged from excellent to satisfactory, requiring moderate clarification, depending on the photo or question. There was wide variability in rater grading agreement, with attendings being the most critical graders.

Conclusions

ChatGPT-4o can provide some satisfactory assessments of simple postoperative clinical photos and responses to common questions after orthopaedic knee and shoulder surgery, as graded by orthopaedic surgeons, residents, and physician assistants. While this study highlights how ChatGPT could serve as a tool for generating draft responses to patient concerns after undergoing orthopaedic knee and shoulder surgery, it cannot yet provide reliable, independent clinical advice.

Clinical Relevance

As digital interactions in health care continue to expand, large language models could play a role in enhancing communication between patients and the orthopaedic care team, potentially improving patient engagement and access to information.
目的评估chatgpt - 40对关节镜或开放手术后膝关节和肩部模拟照片的临床评估能力,并回答与前交叉韧带重建和肩袖修复相关的常见问题。方法制作了一系列术后膝关节和肩部的模拟照片,并对前交叉韧带重建和肩袖修复的常见问题进行了分析。这些临床照片和问题在单独的聊天窗口中提交给GPT,没有经过事先培训,骨科医生、医师助理和住院医生使用先前建立的4分评分系统对其回答进行评分。结果在对ChatGPT模拟临床照片进行评分时,评分者给出了18.8% ~ 75.0%的总优等评分,0% ~ 25.0%的总不满意评分。在对ChatGPT问题的答案进行评分时,评分者给出了4.5%至77.3%的优秀分数,0%至9.1%的不合格分数。平均成绩从优秀到满意,需要适度的澄清,取决于照片或问题。在评分协议方面有很大的差异,主治医生是最关键的评分者。结论atgpt - 40对骨科医生、住院医师和医师助理对膝关节和肩关节手术术后简单的临床照片和常见问题的回答给出了满意的评价。虽然这项研究强调了ChatGPT可以作为一种工具,为接受骨科膝关节和肩部手术后的患者提供草稿反应,但它还不能提供可靠的、独立的临床建议。随着医疗保健中的数字互动不断扩大,大型语言模型可以在加强患者和骨科护理团队之间的沟通方面发挥作用,可能会提高患者的参与度和获取信息的机会。
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引用次数: 0
Protected Weight-Bearing and Early Passive Mobilization Are Common Components of Rehabilitation After Hip Arthroscopy With Labral Reconstruction 保护性负重和早期被动活动是髋关节镜下唇部重建术后康复的常见组成部分
Q3 Medicine Pub Date : 2025-10-01 DOI: 10.1016/j.asmr.2025.101230
Kyle P. Messer D.O. , Jaydeep Dhillon D.O. , Matthew J. Kraeutler M.D.

Purpose

To perform a systematic review of postoperative rehabilitation protocols after hip arthroscopy with labral reconstruction.

Methods

A systematic review was conducted by searching PubMed, the Cochrane Library, and Embase databases for studies reporting postoperative rehabilitation protocols after hip arthroscopy with labral reconstruction. Inclusion criteria were clinical studies detailing rehabilitation protocols after hip arthroscopy with primary labral reconstruction. Studies were excluded if they involved revision procedures, lacked rehabilitation protocols, or were nonclinical reports. The search terms used were: hip labral reconstruction. Extracted data included initial weight-bearing (WB) status, time to full WB, use of continuous passive motion (CPM), initial range of motion limitations, brace use and duration, physical therapy modalities, return-to-sports timing, patient-reported outcome measures, and reoperation rates, defined as the need for revision arthroscopy or conversion to total hip arthroplasty.

Results

Twenty studies, including 641 patients, met inclusion criteria. The mean patient age ranged from 32.0 to 43.7 years, with mean follow-up durations ranging from 0.6 years to 6.4 years. Four studies allowed WB as tolerated, one required non-WB, whereas 15 studies implemented protected WB (i.e., partial WB or touch-down WB) postoperatively, with all studies allowing full WB within 8 weeks. CPM was initiated within 12 to 24 hours postoperatively in 6 studies. Hip immobilization devices were used in 6 studies. Five studies reported range of motion restrictions, limiting hip flexion anywhere from 30° to 90°. Fourteen studies reported 11 unique patient-reported outcome measures and 55% of all studies reported reoperation rates. Among 5 studies that reported return-to-sport timelines, 4 (80%) permitted return by 6 months. Although most protocols discussed physical therapy and strength progression, considerable variability existed regarding exercise timing and initiation.

Conclusions

This systematic review highlights the heterogeneity in postoperative rehabilitation protocols after hip arthroscopy with labral reconstruction, reflecting a lack of standardized, evidence-based guidelines.

Level of Evidence

Level V, systematic review of Level II-V studies.
目的对髋关节镜下唇部重建术后康复方案进行系统综述。方法通过检索PubMed、Cochrane Library和Embase数据库,对报道髋关节镜术后唇部重建术后康复方案的研究进行系统回顾。纳入标准是临床研究详细康复方案后,髋关节镜和初级唇重建。如果研究涉及修订程序、缺乏康复方案或是非临床报告,则排除研究。搜索词为:髋关节唇部重建。提取的数据包括初始负重(WB)状态、达到完全负重的时间、连续被动运动(CPM)的使用、初始运动限制范围、支具的使用和持续时间、物理治疗方式、恢复运动时间、患者报告的结果测量和再手术率(定义为需要翻修关节镜或转换为全髋关节置换术)。结果20项研究,641例患者符合纳入标准。患者平均年龄为32.0 ~ 43.7岁,平均随访时间为0.6 ~ 6.4年。4项研究允许耐受WB, 1项研究要求非WB,而15项研究实施术后保护WB(即部分WB或触底WB),所有研究均允许在8周内完全WB。在6项研究中,CPM在术后12至24小时内开始。在6项研究中使用了髋部固定装置。五项研究报告了活动范围限制,限制髋关节屈曲从30°到90°。14项研究报告了11项独特的患者报告的结果测量,55%的研究报告了再手术率。在报告恢复运动时间表的5项研究中,4项(80%)允许在6个月后恢复。尽管大多数协议讨论了物理治疗和力量进展,但在运动时间和开始方面存在相当大的差异。本系统综述强调了髋关节镜下唇部重建术后康复方案的异质性,反映了缺乏标准化的循证指南。证据水平:V级,II-V级研究的系统评价。
{"title":"Protected Weight-Bearing and Early Passive Mobilization Are Common Components of Rehabilitation After Hip Arthroscopy With Labral Reconstruction","authors":"Kyle P. Messer D.O. ,&nbsp;Jaydeep Dhillon D.O. ,&nbsp;Matthew J. Kraeutler M.D.","doi":"10.1016/j.asmr.2025.101230","DOIUrl":"10.1016/j.asmr.2025.101230","url":null,"abstract":"<div><h3>Purpose</h3><div>To perform a systematic review of postoperative rehabilitation protocols after hip arthroscopy with labral reconstruction.</div></div><div><h3>Methods</h3><div>A systematic review was conducted by searching PubMed, the Cochrane Library, and Embase databases for studies reporting postoperative rehabilitation protocols after hip arthroscopy with labral reconstruction. Inclusion criteria were clinical studies detailing rehabilitation protocols after hip arthroscopy with primary labral reconstruction. Studies were excluded if they involved revision procedures, lacked rehabilitation protocols, or were nonclinical reports. The search terms used were: <em>hip labral reconstruction</em>. Extracted data included initial weight-bearing (WB) status, time to full WB, use of continuous passive motion (CPM), initial range of motion limitations, brace use and duration, physical therapy modalities, return-to-sports timing, patient-reported outcome measures, and reoperation rates, defined as the need for revision arthroscopy or conversion to total hip arthroplasty.</div></div><div><h3>Results</h3><div>Twenty studies, including 641 patients, met inclusion criteria. The mean patient age ranged from 32.0 to 43.7 years, with mean follow-up durations ranging from 0.6 years to 6.4 years. Four studies allowed WB as tolerated, one required non-WB, whereas 15 studies implemented protected WB (i.e., partial WB or touch-down WB) postoperatively, with all studies allowing full WB within 8 weeks. CPM was initiated within 12 to 24 hours postoperatively in 6 studies. Hip immobilization devices were used in 6 studies. Five studies reported range of motion restrictions, limiting hip flexion anywhere from 30° to 90°. Fourteen studies reported 11 unique patient-reported outcome measures and 55% of all studies reported reoperation rates. Among 5 studies that reported return-to-sport timelines, 4 (80%) permitted return by 6 months. Although most protocols discussed physical therapy and strength progression, considerable variability existed regarding exercise timing and initiation.</div></div><div><h3>Conclusions</h3><div>This systematic review highlights the heterogeneity in postoperative rehabilitation protocols after hip arthroscopy with labral reconstruction, reflecting a lack of standardized, evidence-based guidelines.</div></div><div><h3>Level of Evidence</h3><div>Level V, systematic review of Level II-V studies.</div></div>","PeriodicalId":34631,"journal":{"name":"Arthroscopy Sports Medicine and Rehabilitation","volume":"7 5","pages":"Article 101230"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145478981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suture-Button Repair Improves Outcomes in Arthroscopically Diagnosed Chronic Syndesmotic Injury Despite Low Imaging Sensitivity 尽管低成像敏感性,缝合-按钮修复改善关节镜诊断的慢性关节病损伤的预后
Q3 Medicine Pub Date : 2025-10-01 DOI: 10.1016/j.asmr.2025.101227
Tarjei Vinje M.D. , Eivind Inderhaug M.D., Ph.D. , Jon Jarning M.D. , Randi M. Hole M.D., Ph.D. , Nils Vetti M.D., Ph.D , Merete A. Malt P.T. , Kjell Matre M.D., Ph.D.

Purpose

To evaluate patient-reported outcomes after arthroscopic suture-button repair of chronic isolated syndesmotic injuries and to compare the diagnostic sensitivity of standard imaging with arthroscopy.

Methods

Patients with chronic (≥3 months) syndesmotic injuries confirmed by arthroscopy (≥2 mm widening) who underwent suture-button repair between 2017 and 2021 were included. Exclusion criteria were ankle fractures, previous major surgery, or significant arthritis. Foot Function Index and Foot-and-Ankle Ability Measure scores were recorded preoperatively as part of routine clinical assessment and at final follow-up. The minimal clinically important difference was defined as 75% of preoperative standard deviation.

Results

Forty-one patients (43 ankles) were analyzed. Median age was 32 years (15-57 years), 63% were female, and time from injury to surgery was 1.7 years (0.25-25). Fifteen ankles (35%) received concomitant lateral suture-tape stabilization. Arthroscopic syndesmotic widening was 2-3 mm in 5%, 3-4 mm in 10%, >4 mm in 46%, and posterior in 38%. All 6 Foot Function Index and Foot-and-Ankle Ability Measure subscores improved significantly (P < .001), with 79% to 93% achieving minimal clinically important difference at a median 2.3-year follow-up (1.0-4.8). Sensitivity for syndesmotic pathology was 5% for radiographs and stress fluoroscopy, 22% for computed tomography, and 26% for magnetic resonance imaging.

Conclusions

Arthroscopic suture-button repair led to significant improvements in patient-reported outcomes for chronic isolated syndesmotic injuries. Standard imaging had low sensitivity, and a posterior-predominant syndesmotic widening pattern was commonly observed arthroscopically. These findings suggest that chronic syndesmotic instability is underdiagnosed, highlight the role of arthroscopic evaluation for accurate diagnosis, and support the use of suture-button stabilization as an effective treatment.

Level of Evidence

Level IV, therapeutic case series.
目的评价关节镜下缝合-钮扣修复慢性孤立性韧带联合损伤患者报告的结果,并比较标准影像学与关节镜的诊断敏感性。方法纳入2017 - 2021年间经关节镜确认的慢性(≥3个月)韧带联合损伤(≥2mm加宽)患者。排除标准为踝关节骨折、既往大手术或严重关节炎。术前记录足功能指数和足踝能力测量评分,作为常规临床评估的一部分,并在最后随访时记录。最小临床重要差异定义为术前标准差的75%。结果共分析41例(43踝关节)。中位年龄32岁(15-57岁),63%为女性,从损伤到手术时间为1.7年(0.25-25年)。15例(35%)踝关节接受外侧缝合带固定。关节镜下关节联合增宽为2-3毫米的占5%,3-4毫米的占10%,4毫米的占46%,后路的占38%。所有6项足功能指数和足踝能力测量评分均显著改善(P < .001),在中位随访2.3年(1.0-4.8)时,79%至93%达到最小的临床重要差异。x线片和应力透视对关节病病理的敏感性为5%,计算机断层扫描为22%,磁共振成像为26%。结论腹腔镜缝合-钮扣修复术显著改善了慢性孤立性胫腓联合损伤患者报告的预后。标准成像灵敏度低,关节镜下通常观察到后显性韧带联合变宽。这些发现提示慢性关节病不稳定未被充分诊断,强调了关节镜评估对准确诊断的作用,并支持使用缝线扣固定作为有效的治疗方法。证据水平:IV级,治疗性病例系列。
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引用次数: 0
Margin Convergence Yields Comparable Clinical Outcomes With Repair Using the Interval Slide Technique in Patients Who Had Undergone Complete Repair of Large-to-Massive Rotator Cuff Tears 对于接受大到大块肩袖撕裂完全修复的患者,边缘收敛与间隔滑动技术修复的临床效果相当
Q3 Medicine Pub Date : 2025-10-01 DOI: 10.1016/j.asmr.2025.101214
W.P. Yau M.B.B.S., F.R.C.S.Ed., F.R.C.S.Ed. (Ortho.), F.H.K.C.O.S., F.H.K.A.M. (Orthopaedic Surgery)

Purpose

To compare the outcomes of complete repairs for large-to-massive rotator cuff tears between patients who underwent the margin convergence (MC) or interval slide technique (IS).

Methods

A retrospective study was conducted. The inclusion criteria included patients who received primary repairs using either MC or IS to address a large-to-massive rotator cuff tear between 2007 and 2020. Clinical outcomes, including visual analog scale score, American Shoulder and Elbow Surgeons score, and active shoulder forward flexion (FF), were assessed at the 2-year follow-up. Minimal clinically important difference (MCID) was calculated. Magnetic resonance imaging (MRI) was performed at the 2-year follow-up.

Results

The number of patients operated on with IS and MC technique was 59 and 24, respectively, including 42 male and 41 female patients, with an average age of 62.5 ± 10 years. The 2-year follow-up rate was 91%. Postoperative MRIs were performed at 17.8 ± 7.3 months. The rates of full-thickness retear were 88% for MC and 27% for IS. One patient (4%) who was operated on with MC, compared with 2 patients who underwent IS (3%), received revision surgeries. There were no differences between the 2 repair techniques in terms of visual analog scale score, American Shoulder and Elbow Surgeons Score, and FF at the 2-year follow-up. However, more patients in the IS group achieved MCID for ASES (93% and 67%, respectively; P = .006) and FF (62% and 30%, respectively; P = .016), compared with those who underwent MC. The odds ratio were 7.2 (95% confidence interval 1.6-33) and 3.7 (95% confidence interval 1.2-11.3), respectively.

Conclusions

Both margin convergence and interval slide techniques are effective methods for improving clinical outcomes in patients with large-to-massive rotator cuff tears, despite a 3-fold greater full-thickness retear rate observed on postoperative MRI and a lower likelihood of achieving MCID for ASES and FF in the MC group.

Level of Evidence

Level III, retrospective comparative case series.
目的比较边缘收敛术(MC)和间隙滑动术(IS)对大到大块肩袖撕裂的完全修复效果。方法采用回顾性研究。纳入标准包括2007年至2020年间使用MC或IS进行初级修复以解决大到大面积肩袖撕裂的患者。临床结果,包括视觉模拟量表评分、美国肩关节外科医生评分和主动肩关节前屈度(FF),在2年的随访中进行评估。计算最小临床重要差异(MCID)。2年随访时进行磁共振成像(MRI)检查。结果采用IS和MC技术分别手术59例和24例,其中男性42例,女性41例,平均年龄62.5±10岁。2年随访率为91%。术后17.8±7.3个月行mri检查。MC和IS的全层恢复率分别为88%和27%。1例(4%)接受了MC手术,2例(3%)接受了IS手术。2年随访时,两种修复技术在视觉模拟量表评分、美国肩关节外科医生评分和FF方面没有差异。然而,与接受MC的患者相比,IS组患者在as(分别为93%和67%,P = 0.006)和FF(分别为62%和30%,P = 0.016)方面达到了MCID,优势比分别为7.2(95%可信区间1.6-33)和3.7(95%可信区间1.2-11.3)。结论边缘收敛和间隔滑动技术都是改善大到大块肩袖撕裂患者临床结果的有效方法,尽管在术后MRI上观察到全层撕裂率高出3倍,并且MC组实现asas和FF的MCID的可能性较低。证据等级:III级,回顾性比较病例系列。
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引用次数: 0
Autologous Peripheral Blood Stem Cells With Adjuvant Hyaluronic Acid Enhance Cartilage Repair After Subchondral Drilling in a Sheep Model 自体外周血干细胞与辅助透明质酸增强羊软骨下钻孔后软骨修复模型
Q3 Medicine Pub Date : 2025-10-01 DOI: 10.1016/j.asmr.2025.101217
Caroline Siew Yoke Jee B.Eng. (Hons.), Ph.D. , Alisha Ramlan B.Sc. , Razana Mohd Ali M.B.B.S. (U.T.A.S.), M.P.A.T.H. (U.K.M.), A.M. (M.A.L.). , Nurul Hayah Khairuddin D.A.H.P. (U.P.M.), D.V.M. (U.P.M.), Ph.D. (U.K.) , Hui Cheng Chen D.V.M., MV.M., D.V.Sc. , Amal Dawam M.Sc. , Yan-Chang Saw M.B. Ch.B. , Khay-Yong Saw M.Ch.Orth., F.R.C.S.(Edin).

Purpose

To determine histologically whether intra-articular injections of autologous peripheral blood stem cells (PBSC) and adjuvant hyaluronic acid (HA) after subchondral drilling result in better articular cartilage repair.

Methods

Fifteen sheep (aged 12-36 months) were included in this study. An 8-mm full-thickness cartilage defect was created. There were 3 groups: group A, which comprised 5 control (subchondral drilling only); group B, which comprised 5 subchondral drilling + HA (3 injections); and group C, which comprised 5 subchondral drilling + PBSC + HA (3 injections). Each injection was given intra-articularly at 7 days apart. Animals were killed humanely at 6 months after operation. The left stifle joint was examined macroscopically as well as histologically (hematoxylin and eosin, safranin-O, collagen type 1 and 2, International Cartilage Regeneration & Joint Preservation Society [ICRS] II scale).

Results

All the animals survived the duration of the study. Macroscopic evaluation showed the presence of repair tissues in all groups, although the chondral defects were not completely filled with repair cartilage. Greater ICRS II scores indicate better chondrogenesis. Group C (902 ± 229) showed significantly greater ICRS II scores compared with group A (536 ± 81) and group B (563 ± 83), with P values of .014 and .016, respectively. However, the scores for group C were lower to those of normal cartilage (1266 ± 35), with a P of .014.

Conclusions

In this sheep model, postoperative intra-articular injections of autologous PBSCs with HA were associated with better histologic cartilage repair after subchondral drilling when compared with HA alone, as assessed using the ICRS II scoring system.

Clinical Relevance

This large animal study shows that intra-articular injections of autologous PBSC combined with HA are associated with improved histologic features of cartilage repair after subchondral drilling, supporting further investigation of this approach in preclinical models and the findings may have relevance in guiding future treatment strategies for cartilage defects in humans.
目的从组织学上观察软骨下钻孔后关节内注射自体外周血干细胞(PBSC)和辅助透明质酸(HA)是否能更好地修复关节软骨。方法选取12-36月龄绵羊15只。形成一个8毫米全层软骨缺损。随机分为3组:A组,对照组5只(仅在软骨下钻孔);B组,5次软骨下钻孔+ HA(3次注射);C组5次软骨下钻孔+ PBSC + HA(3次注射)。每次关节内注射间隔7天。动物于术后6个月被人道宰杀。对左膝关节进行宏观和组织学检查(苏木精和伊红,红花素- 0,1型和2型胶原蛋白,国际软骨再生和关节保存协会[ICRS] II级)。结果所有动物在研究期间均存活。肉眼观察均可见修复组织的存在,但软骨缺损未完全被修复软骨填充。ICRS II评分越高,表明软骨形成越好。C组ICRS II评分(902±229)明显高于A组(536±81)和B组(563±83),P值为。014和。016年,分别。C组的评分低于正常软骨组(1266±35)分,P值为0.014。结论在该羊模型中,使用ICRS II评分系统评估,与单独使用HA相比,术后关节内注射含有HA的自体PBSCs与软骨下钻孔后更好的组织学软骨修复相关。这项大型动物研究表明,关节内注射自体PBSC联合HA与软骨下钻孔后软骨修复的组织学特征改善有关,支持在临床前模型中进一步研究这种方法,研究结果可能对指导人类软骨缺陷的未来治疗策略具有相关性。
{"title":"Autologous Peripheral Blood Stem Cells With Adjuvant Hyaluronic Acid Enhance Cartilage Repair After Subchondral Drilling in a Sheep Model","authors":"Caroline Siew Yoke Jee B.Eng. (Hons.), Ph.D. ,&nbsp;Alisha Ramlan B.Sc. ,&nbsp;Razana Mohd Ali M.B.B.S. (U.T.A.S.), M.P.A.T.H. (U.K.M.), A.M. (M.A.L.). ,&nbsp;Nurul Hayah Khairuddin D.A.H.P. (U.P.M.), D.V.M. (U.P.M.), Ph.D. (U.K.) ,&nbsp;Hui Cheng Chen D.V.M., MV.M., D.V.Sc. ,&nbsp;Amal Dawam M.Sc. ,&nbsp;Yan-Chang Saw M.B. Ch.B. ,&nbsp;Khay-Yong Saw M.Ch.Orth., F.R.C.S.(Edin).","doi":"10.1016/j.asmr.2025.101217","DOIUrl":"10.1016/j.asmr.2025.101217","url":null,"abstract":"<div><h3>Purpose</h3><div>To determine histologically whether intra-articular injections of autologous peripheral blood stem cells (PBSC) and adjuvant hyaluronic acid (HA) after subchondral drilling result in better articular cartilage repair.</div></div><div><h3>Methods</h3><div>Fifteen sheep (aged 12-36 months) were included in this study. An 8-mm full-thickness cartilage defect was created. There were 3 groups: group A, which comprised 5 control (subchondral drilling only); group B, which comprised 5 subchondral drilling + HA (3 injections); and group C, which comprised 5 subchondral drilling + PBSC + HA (3 injections). Each injection was given intra-articularly at 7 days apart. Animals were killed humanely at 6 months after operation. The left stifle joint was examined macroscopically as well as histologically (hematoxylin and eosin, safranin-O, collagen type 1 and 2, International Cartilage Regeneration &amp; Joint Preservation Society [ICRS] II scale).</div></div><div><h3>Results</h3><div>All the animals survived the duration of the study. Macroscopic evaluation showed the presence of repair tissues in all groups, although the chondral defects were not completely filled with repair cartilage. Greater ICRS II scores indicate better chondrogenesis. Group C (902 ± 229) showed significantly greater ICRS II scores compared with group A (536 ± 81) and group B (563 ± 83), with <em>P</em> values of .014 and .016, respectively. However, the scores for group C were lower to those of normal cartilage (1266 ± 35), with a <em>P</em> of .014.</div></div><div><h3>Conclusions</h3><div>In this sheep model, postoperative intra-articular injections of autologous PBSCs with HA were associated with better histologic cartilage repair after subchondral drilling when compared with HA alone, as assessed using the ICRS II scoring system.</div></div><div><h3>Clinical Relevance</h3><div>This large animal study shows that intra-articular injections of autologous PBSC combined with HA are associated with improved histologic features of cartilage repair after subchondral drilling, supporting further investigation of this approach in preclinical models and the findings may have relevance in guiding future treatment strategies for cartilage defects in humans.</div></div>","PeriodicalId":34631,"journal":{"name":"Arthroscopy Sports Medicine and Rehabilitation","volume":"7 5","pages":"Article 101217"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145478852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Arthroscopy Sports Medicine and Rehabilitation
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