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Prof. Richard Sutton's lifelong research: Pacing and syncope 理查德-萨顿教授的毕生研究:起搏与晕厥
Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-10-01 DOI: 10.4103/hm.hm-d-23-00057
Richard Sutton, Doris Yang, Meiyan Liu
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引用次数: 0
Vital interconnections between heart and mind 心与心之间的重要联系
Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-10-01 DOI: 10.4103/hm.hm-d-23-00041
Randall Stafford
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引用次数: 0
Prof. Fausto J. Pinto: More of a leading figure and passionate cardiologist 福斯托-J-平托教授:更多的领军人物和充满激情的心脏病专家
Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-10-01 DOI: 10.4103/hm.hm-d-23-00054
Fausto Pinto, Doris Yang, Meiyan Liu
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引用次数: 0
Short- and long-term effects of COVID-19 on psychological and cardiovascular functions COVID-19 对心理和心血管功能的短期和长期影响
Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-10-01 DOI: 10.4103/hm.hm-d-23-00059
Lin Lu
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引用次数: 0
A narrative review on increased prevalence of cardiovascular complications following a COVID-19 infection: The risks and considerations for effective management and practice 关于 COVID-19 感染后心血管并发症发生率增加的叙述性综述:有效管理和实践的风险与注意事项
Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-10-01 DOI: 10.4103/hm.hm-d-23-00038
Mark Faghy, Ruth M. Ashton
The COVID-19 pandemic has been one of the largest risks to global population health in recent years, and acute infection and the persistent symptoms of long COVID will likely continue to affect global health for years to come. Long COVID is very complex and impacts multiple systems and organs, resulting in an extensive and undulating presentation of symptoms. COVID-19 has been shown to cause various cardiovascular (CV) injuries following acute infection, with many patients suffering long-lasting impairment. This review article discusses the prevalence of CV complications following an acute COVID-19 infection and considers effective prevention and disease management strategies to help restore functional status and quality of life in patients.
COVID-19 大流行是近年来全球人口健康面临的最大风险之一,急性感染和长期 COVID 的持续症状可能会在未来数年继续影响全球健康。长COVID非常复杂,影响多个系统和器官,导致症状表现广泛且起伏不定。有研究表明,COVID-19 在急性感染后会造成各种心血管 (CV) 损伤,许多患者会长期受损。这篇综述文章讨论了急性 COVID-19 感染后心血管并发症的发生率,并探讨了有效的预防和疾病管理策略,以帮助患者恢复功能状态,提高生活质量。
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引用次数: 0
A narrative review on prediabetes or diabetes and atrial fibrillation: From molecular mechanisms to clinical practice 关于糖尿病前期或糖尿病与心房颤动的叙述性综述:从分子机制到临床实践
Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-10-01 DOI: 10.4103/hm.hm-d-23-00028
Xuyao Han, Ying Liu, Guangping Li, Gary Tse, Tong Liu
Based on glucose levels, people fall into three groups, normal individuals, prediabetic patients, and diabetic mellitus (DM) patients. Prediabetes (pre-DM) is an intermediate condition that exists between normal glucose levels and DM. Atrial fibrillation (AF), one of the most prevalent cardiac arrhythmias in medical practice, contributes to a considerable morbidity and mortality rate. In this review, we looked at the clinical symptoms, pathological alterations, molecular mechanisms, and associated risk factors of pre-DM, type 2 DM (T2DM), and AF. In clinical practice, pre-DM can increase the prevalence of AF. In the hyperglycemic state, oxidative stress, inflammation, and endoplasmic reticulum stress can cause alterations in atrial cell or cardiac fibroblast function through tumor necrosis factor-α/nuclear factor-κB (NF-κB)/transforming growth factor-β, mitogen-activated protein kinase-matrix metalloproteinase-9 and PARP-1 is poly (ADP-ribose) polymerase 1. IκB kinase-α/NF-κB pathways, and further cause atria undergo structural, electrical, and neural remodeling which lead to the occurrence and persistence of AF. In addition, pre-DM and T2DM may worsen as a result of obesity, obstructive sleep apnea, and arterial hypertension. Furthermore, clinical researches have demonstrated that lifestyle interventions and/or pharmacotherapy in pre-DM patients can effectively delay the progresssion of pre-DM to T2DM. Individualized glycemic management and AF management should be provided to AF patients with pre-DM or DM.
根据血糖水平,人们可分为三类:正常人、糖尿病前期患者和糖尿病(DM)患者。糖尿病前期(糖尿病前期)是介于正常血糖水平和糖尿病之间的一种中间状态。心房颤动(房颤)是医疗实践中最常见的心律失常之一,导致了相当高的发病率和死亡率。在这篇综述中,我们探讨了糖尿病前期、2 型糖尿病(T2DM)和房颤的临床症状、病理改变、分子机制和相关风险因素。在临床实践中,DM前期可增加房颤的患病率。在高血糖状态下,氧化应激、炎症和内质网应激可通过肿瘤坏死因子-α/核因子-κB(NF-κB)/转化生长因子-β、丝裂原活化蛋白激酶-基质金属蛋白酶-9和PARP-1(多聚(ADP-核糖)聚合酶1)引起心房细胞或心脏成纤维细胞功能的改变。IκB 激酶-α/NF-κB 通路,并进一步导致心房发生结构、电和神经重塑,从而导致房颤的发生和持续。此外,肥胖、阻塞性睡眠呼吸暂停和动脉高血压也可能导致前期糖尿病和 T2DM 病情加重。此外,临床研究表明,对糖尿病前期患者进行生活方式干预和/或药物治疗,可有效延缓糖尿病前期向糖尿病中期发展。对于有糖尿病前期或糖尿病的房颤患者,应提供个体化的血糖管理和房颤管理。
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引用次数: 0
Mental health symptoms and illness trajectory following COVID-19 hospitalization: A cohort study COVID-19 住院治疗后的精神健康症状和疾病轨迹:一项队列研究
Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-10-01 DOI: 10.4103/hm.hm-d-23-00037
Harriet Lomholt-Welch, A. Morrow, R. Sykes, Merna Saleh, Baryab Zahra, Alasdair MacIntosh, Anna Kamdar, Catherine Bagot, Hannah Bayes, Kevin Blyth, H. Bulluck, D. Carrick, Colin Church, D. Corcoran, Iain Findlay, V. Gibson, L. Gillespie, D. Grieve, Pauline Barrientos, Antonia Ho, Ninian N Lang, David Lowe, V. Lennie, Peter Macfarlane, Kaitlin J. Mayne, Patrick B. Mark, A. Mcconnachie, R. McGeoch, Sabrina Nordin, Alexander Payne, Alastair Rankin, K. Robertson, N. Ryan, Giles Roditi, Naveed Sattar, D. Stobo, Sarah Allwood-Spiers, R. Touyz, G. Veldtman, S. Weeden, R. Weir, S. Watkins, P. Welsh, K. Mangion, Colin Berry
Background: The multisystem associations between baseline mental health status and coronavirus disease-19 (COVID)-19 illness trajectory are uncertain. Objectives: This article will investigate the associations between baseline mental health status and disease trajectory following COVID-19 hospitalization, which may have implications for practice and future research. Methods: The Chief Scientist Office Cardiovascular and Pulmonary Imaging in severe acute respiratory syndrome (SARS) COVID-19 study is a prospective, observational, multicenter, longitudinal, secondary care cohort study that assessed the time-course of multi-organ injury in posthospital survivors of COVID-19. Patients were assessed in-hospital, at 28–60 days after discharge and in the longer term using electronic health record linkage. Results: One hundred and fifty-two patients (mean ± standard deviation [SD] age 54.3 ± 11.8 years, 43% female, 40% most socio-economically deprived quintile, 33% history of mental health history) were enrolled and had mental health serially assessed using the Patient Health Questionnaire-4 (PHQ-4) questionnaire. Fifty-three (35%) had PHQ-4 score of 6–12 consistent with moderate-severe symptoms of anxiety or depression and this was associated with diagnostic criteria for myocarditis (P = 0.0498). Moderate-severe symptoms of anxiety or depression were positively associated with higher perception of illness, lower health-related quality of life (HRQoL), and poorer physical function. The mean (SD) duration of follow-up after hospital discharge was 428 (86) days (range, 290–627 days). PHQ-4 score was not associated with clinical outcomes at follow-up. Conclusions: In patients who have been hospitalized with COVID-19, moderate-severe symptoms of anxiety or depression were associated with myocarditis, worse HRQoL, higher perception of illness, and lower levels of physical function. Public Registration: ClinicalTrials.gov identifier is NCT04403607.
背景:基线心理健康状况与19型冠状病毒病(COVID)-19发病轨迹之间的多系统关联尚不确定。目的:本文将研究基线精神健康状况与冠状病毒疾病-19(COVID-19)发病轨迹之间的关系:本文将研究基线心理健康状况与 COVID-19 住院后的疾病轨迹之间的关联,这可能对实践和未来研究产生影响。研究方法严重急性呼吸系统综合征(SARS)COVID-19 首席科学家办公室心血管和肺部成像研究是一项前瞻性、观察性、多中心、纵向、二级护理队列研究,旨在评估 COVID-19 住院后幸存者多器官损伤的时间进程。通过电子病历链接对患者在院内、出院后 28-60 天以及更长期的情况进行评估。结果:152名患者(平均±标准差[SD]年龄为54.3±11.8岁,43%为女性,40%为社会经济最贫困的五分之一人口,33%有精神疾病史)接受了登记,并使用患者健康问卷-4(PHQ-4)对其精神健康状况进行了连续评估。53人(35%)的PHQ-4得分在6-12分之间,符合中重度焦虑或抑郁症状,这与心肌炎的诊断标准有关(P = 0.0498)。中度严重焦虑或抑郁症状与较高的疾病感知、较低的健康相关生活质量(HRQoL)和较差的身体功能呈正相关。出院后的平均(标清)随访时间为 428 (86) 天(范围为 290-627 天)。PHQ-4 评分与随访时的临床结果无关。结论在因 COVID-19 而住院的患者中,中度-重度焦虑或抑郁症状与心肌炎、较差的 HRQoL、较高的疾病感知和较低的身体功能水平有关。公开注册:ClinicalTrials.gov 识别码为 NCT04403607。
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引用次数: 0
Pattern and associated factors of cognitive failures in the general chinese population during the early stages of the COVID-19 pandemic: A cross-sectional study COVID-19大流行初期中国普通人群认知障碍的模式及相关因素:横断面研究
Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-10-01 DOI: 10.4103/hm.hm-d-23-00033
Wei Yan, Shuyu Ni, Chang Liu, Junliang Yuan, Yimiao Zhao, Na Zeng, Huan Mei, Shuilin Wu, Jianyu Que, K. Yuan, Le Shi, Siwei Sun, Shiqiu Meng, Maosheng Ran, Y. Leng, Arun Ravindran, Jie Shi, Yanping Bao, Lin Lu
Background: The coronavirus disease-2019 (COVID-19) pandemic worldwide has caused a high burden of mental problems, which may be associated with subjective cognitive impairment in the general population. Objectives: This cross-sectional survey aimed to investigate the level and pattern of cognitive failure (CF) and its negative changes during the COVID-19 pandemic among the general population in China. Methods: The participants completed an online questionnaire between April 18 and May 4, 2020, and those aged between 18 and 70 were included in this study. CF was measured using the 14-item CF Questionnaire (CFQ-14). Factors associated with CF and negative changes in CF were evaluated using multiple linear and logistic regression models. A total of 30,879 eligible participants were recruited; most were female (59.10%) and aged 31–45 (61.51%). Results: The mean CFQ-14 score was 15.62 (standard deviation = 11.55), and 4,619 (14.96%) participants reported negative changes in CF during the pandemic. Multiple regression analyses showed that participants with female gender, history of physical and mental disease, the self-perceived influence of COVID-19, altered appetite and taste preference, worse interpersonal relationships, long sleep duration, poor sleep quality, depressive, anxiety and posttraumatic stress disorder symptoms had a higher level of CF and negative CF changes, while regular exercise was associated with a lower risk of both outcomes. Conclusions: This study indicates that CF symptoms should be monitored in the general population during pandemics. A healthy lifestyle and reduction in psychological stress could help promote normal cognitive function during pandemics.
背景:冠状病毒病-2019(COVID-19)在全球范围内的大流行造成了大量精神问题,这可能与普通人群的主观认知障碍有关。调查目的本横断面调查旨在研究中国普通人群在 COVID-19 大流行期间的认知功能障碍(CF)水平、模式及其负面变化。调查方法参与者在 2020 年 4 月 18 日至 5 月 4 日期间填写了一份在线问卷,年龄在 18 岁至 70 岁之间的人被纳入本研究。CF采用14项CF问卷(CFQ-14)进行测量。使用多元线性和逻辑回归模型评估了与 CF 和 CF 负性变化相关的因素。共招募了 30879 名符合条件的参与者,其中大多数为女性(59.10%),年龄在 31-45 岁之间(61.51%)。研究结果CFQ-14 的平均得分为 15.62(标准差 = 11.55),4,619 名参与者(14.96%)报告了大流行期间 CF 的负面变化。多元回归分析表明,性别为女性、有身体和精神疾病史、自我感觉受 COVID-19 影响、食欲和口味偏好改变、人际关系较差、睡眠时间长、睡眠质量差、有抑郁、焦虑和创伤后应激障碍症状的参与者的 CF 和 CF 负性变化水平较高,而经常锻炼则与这两种结果的风险较低有关。结论这项研究表明,在流行病期间,应监测普通人群的 CF 症状。健康的生活方式和减轻心理压力有助于促进大流行病期间的正常认知功能。
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引用次数: 0
Exploring the association between serum β-Carotene and metabolic syndrome in patients with schizophrenia 探索精神分裂症患者血清β-胡萝卜素与代谢综合征之间的关系
Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-10-01 DOI: 10.4103/hm.hm-d-23-00015
H. Jahrami, Zahra Saif, Khaled Trabelsi, S. Pandi‑Perumal, Mary V. Seeman
Background and Aims: There has been no previous investigation into the relationship between serum β-Carotene levels and metabolic syndrome in patients with schizophrenia. This research aims to explore the association between schizophrenia, metabolic syndrome, and serum β-Carotene levels. Specifically, this study addresses this knowledge gap and examines whether lower serum β-Carotene levels are associated with an increased risk for metabolic syndrome in patients with schizophrenia. Methods and Results: The present study involved 38 patients with schizophrenia (n = 38). We collected demographic data, anthropometric measurements, blood samples for lipid panels, sugar levels, and serum β-Carotene levels, as well as participant responses to food frequency questionnaires. Results revealed the median serum β-Carotene was 0.87 (range: 0.69–1.14 μmol/L). The median metabolic syndrome Z-score using waist circumference was 0.13 (range: −1.10–2.39). Pairwise Spearman's correlation between metabolic syndrome Z-score versus β-Carotene showed a rho = −0.56, P < 0.001 for the overall sample. Linear regression between metabolic syndrome Z-score as a dependent variable and serum β-Carotene as an independent variable showed a regression coefficient of −3.11, P < 0.001. Conclusion: The findings of this study offer suggestive evidence of a statistically significant positive correlation between reduced serum β-Carotene levels in individuals with schizophrenia and a heightened global risk of developing metabolic syndrome. This preliminary study has implications for the management of schizophrenia patients, suggesting that patients' serum levels of β-Carotene be periodically checked and referrals made to dieticians as necessary.
研究背景和目的:目前还没有关于精神分裂症患者血清β-胡萝卜素水平与代谢综合征之间关系的研究。本研究旨在探讨精神分裂症、代谢综合征和血清β-胡萝卜素水平之间的关系。具体而言,本研究针对这一知识空白,探讨血清β-胡萝卜素水平较低是否与精神分裂症患者代谢综合征风险增加有关。方法和结果:本研究涉及 38 名精神分裂症患者(n = 38)。我们收集了人口统计学数据、人体测量数据、血脂样本、血糖水平、血清β-胡萝卜素水平以及参与者对食物频率问卷的回答。结果显示,血清β-胡萝卜素的中位数为 0.87(范围:0.69-1.14 μmol/L)。使用腰围计算的代谢综合征 Z 值中位数为 0.13(范围:-1.10-2.39)。代谢综合征 Z 评分与 β-胡萝卜素之间的配对 Spearman 相关性显示,总体样本的 rho = -0.56,P < 0.001。代谢综合征 Z 评分作为因变量,血清 β-胡萝卜素作为自变量,两者之间的线性回归显示回归系数为 -3.11,P <0.001。结论本研究的结果提供了提示性证据,表明精神分裂症患者血清中β-胡萝卜素水平的降低与代谢综合征发病风险的增加之间存在统计学意义上的显著正相关。这项初步研究对精神分裂症患者的管理具有重要意义,建议定期检查患者血清中的β-胡萝卜素水平,并在必要时将患者转介给营养师。
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引用次数: 0
Short- and long-term effects of the COVID-19 pandemic on patients with cardiovascular diseases: A mini-review COVID-19 大流行对心血管疾病患者的短期和长期影响:微型综述
Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-10-01 DOI: 10.4103/hm.hm-d-23-00043
Daniel Caldeira, Joana Brito, Catarina Gregório, Rui Plácido, Fausto Pinto
The COVID-19 pandemic had profound implications for patients with cardiovascular diseases (CVDs), both in the short- and long-term. In this article, we provide an overview of the effects of the pandemic on individuals with preexisting cardiovascular conditions. In the short term, the severe acute respiratory syndrome coronavirus 2 infection increased the risk of many cardiovascular events. Furthermore, the pandemic has disrupted health-care systems worldwide, leading to constraints in routine care, and limited access to specialized cardiovascular services and procedure. This has resulted in increased morbidity and mortality rates among patients with CVD (coronary artery disease, hypertrophic cardiomyopathy, heart failure (HF), heart transplant recipients, atrial fibrillation, atrial flutter, previous stroke, or previous peripheral artery disease). In the long term, the COVID-19 impact on patients with CVD extends beyond the acute phase of the disease. Studies have highlighted the development of long-term cardiovascular complications in COVID-19 survivors, such as acute coronary syndrome myocarditis, HF, stroke, venous thromboembolism, and arrhythmias, which may lead to a surge of new cases associated with CVD in the postpandemic era. Health-care systems must prioritize cardiovascular care, developing strategies to identify the patients at higher risk and provide the care to minimize the impact of the pandemic on patients with CVD.
COVID-19 大流行对心血管疾病(CVD)患者产生了深远的短期和长期影响。在这篇文章中,我们将概述大流行对原有心血管疾病患者的影响。从短期来看,严重急性呼吸系统综合征冠状病毒 2 感染增加了许多心血管事件的风险。此外,疫情扰乱了世界各地的医疗保健系统,导致常规护理受到限制,获得专门的心血管服务和程序的机会有限。这导致心血管疾病(冠心病、肥厚型心肌病、心力衰竭(HF)、心脏移植受者、心房颤动、心房扑动、中风或外周动脉疾病)患者的发病率和死亡率上升。从长远来看,COVID-19 对心血管疾病患者的影响超出了疾病的急性期。研究强调,COVID-19 存活者会出现长期心血管并发症,如急性冠状动脉综合征心肌炎、高血压、中风、静脉血栓栓塞和心律失常,这可能会导致在疫情后时代与心血管疾病相关的新病例激增。医疗保健系统必须优先考虑心血管病护理,制定战略以识别高危患者并提供护理,从而最大限度地减少大流行对心血管病患者的影响。
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Heart and Mind
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