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Chemotherapy response assessment using ultrasound in ovarian cancer 利用超声波评估卵巢癌的化疗反应
Q4 Medicine Pub Date : 2024-07-01 DOI: 10.1136/gocm-2024-000026
A. El-Agwany
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引用次数: 0
Minimally invasive methods with no fibroid surgical removal to treat uterine fibroids: utility or advertising? 不进行子宫肌瘤手术切除的微创方法治疗子宫肌瘤:实用还是广告?
Q4 Medicine Pub Date : 2024-07-01 DOI: 10.1136/gocm-2024-000020
Andrea Tinelli
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引用次数: 0
Comparative study of physical activity status and food patterns in adolescents with and without polycystic ovary syndrome: an analytical approach 多囊卵巢综合征青少年与非多囊卵巢综合征青少年体力活动状况和饮食模式的比较研究:一种分析方法
Q4 Medicine Pub Date : 2024-07-01 DOI: 10.1136/gocm-2024-000007
Sepideh Rezaei Ghamsari, Shahla Faal Siahkal, Bibihajar Zahmatkesh, Elham Ebrahimi
Polycystic ovary syndrome (PCOS) in adolescents causes appearance changes such as hirsutism, alopecia, acne and long-term complications, such as metabolic syndrome and infertility. This study aimed to compare physical activity status and food patterns, as prominent predictive factors, in adolescents with and without PCOS.This study was a cross-sectional study conducted on 400 adolescents at health centres affiliated with Golestan University of Medical Sciences. The data collection tools include a demographic questionnaire, a standard adolescents’ Physical Activity Status Questionnaire and a Nutritional Status Questionnaire. SPSS V.20 software was used to analyse the data.The mean age of participants was 19.16±3.18. The results of the study showed that height, weight and menstrual status were significantly different between the two groups (p<0.05). The calorie intake in affected adolescents was high, and the physical activity status was unfavourable (p<0.05).Adolescents with PCOS have been found to have different physical activity levels, nutritional patterns and calorie intake compared to non-affected individuals. This is a critical issue, as high caloric intake and insufficient physical activity can exacerbate the development of PCOS in adolescents.
青少年多囊卵巢综合征(PCOS)会导致多毛、脱发、痤疮等外貌变化以及代谢综合征和不孕症等长期并发症。本研究旨在比较患有和未患有多囊卵巢综合症的青少年的体育锻炼状况和饮食模式,因为这两项因素是主要的预测因素。本研究是一项横断面研究,对象是戈勒斯坦医科大学附属健康中心的 400 名青少年。数据收集工具包括人口统计学问卷、标准青少年体育活动状况问卷和营养状况问卷。参与者的平均年龄为(19.16±3.18)岁。研究结果显示,两组受试者的身高、体重和月经状况存在显著差异(P<0.05)。研究发现,患有多囊卵巢综合症的青少年与未患病的青少年相比,其体育锻炼水平、营养模式和卡路里摄入量都有所不同。这是一个至关重要的问题,因为高热量摄入和体力活动不足会加剧青少年多囊卵巢综合症的发展。
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引用次数: 0
Continuity of care by a primary midwife (caseload midwifery): a cost analysis using results from the COSMOS randomised controlled trial 初级助产士持续护理(个案助产):利用 COSMOS 随机对照试验结果进行成本分析
Q4 Medicine Pub Date : 2024-06-01 DOI: 10.1136/gocm-2024-000008
Emily J Callander, Hannah Jackson, H. McLachlan, Mary-Ann Davey, Della A Forster
Caseload midwifery (continuity of midwifery carer) offers benefits including lower caesarean section rates, lower risks of preterm birth and stillbirth, and improved maternal satisfaction of care. Despite these advantages, concerns about additional costs hinder widespread implementation. This study examines the cost of caseload midwifery compared with standard maternity care from the perspective of both public hospitals and public funders.A cost analysis was conducted using data from a randomised controlled trial of 2314 low-risk pregnant women in Melbourne, Australia. Women randomised to caseload care received antenatal, intrapartum and postpartum care from a primary midwife, with some care provided by a ‘back-up’ midwife. Women in standard care received midwifery-led care with varying levels of continuity, junior obstetric care or community-based medical care. The cost analysis compared differences in mean costs of health resources to public hospitals and to public funders. Additionally, a budget impact analysis estimated total costs to the health system between 2023 and 2027.For public hospitals, there was no significant difference in overall costs between women receiving caseload midwifery (n=1146) versus standard care (n=1151) ($A12 363 (SD: $A4967) vs $A12 323 (SD: $A7404); p=0.85). Conversely, public funders incurred lower expenditures for women receiving caseload midwifery ($A20 330 (SD: $A8312)) versus standard care ($A21 637 (SD: $A11 818); p <0.001). The budget impact analysis estimated savings of $A625 million to the health system over the next 5 years with expanded access to caseload midwifery in Australia.Caseload midwifery in low-risk women is cost-neutral to public hospitals and cost-saving to public funders.Continuity of midwifery for low-risk women reduces costs to public funders, with no additional costs to hospitals.
个案助产(助产护理人员的连续性)带来的好处包括降低剖腹产率、降低早产和死产风险,以及提高产妇对护理的满意度。尽管有这些优点,但对额外成本的担忧阻碍了其广泛实施。本研究从公立医院和公共资助者的角度出发,对个案助产与标准产科护理的成本进行了比较分析。被随机分配接受个案护理的妇女在产前、产中和产后均接受一名初级助产士的护理,并由一名 "后备 "助产士提供部分护理。接受标准护理的妇女则接受由助产士主导的不同程度的连续性护理、初级产科护理或社区医疗护理。成本分析比较了公立医院和公共资助者的医疗资源平均成本差异。此外,预算影响分析还估算了2023年至2027年期间卫生系统的总成本。对于公立医院而言,接受个案助产护理(n=1146)与标准护理(n=1151)的妇女在总成本上没有显著差异(12 363澳元(标清:4967澳元)vs12 323澳元(标清:7404澳元);p=0.85)。相反,接受个案助产服务的妇女(20 330 澳元(标准差:8312 澳元))与接受标准护理的妇女(21 637 澳元(标准差:11 818 澳元);P <0.001)相比,公共资助者的支出较低。预算影响分析估计,在未来5年内,澳大利亚扩大使用个案助产服务可为卫生系统节省6.25亿澳元。对低风险妇女实施个案助产服务对公立医院来说不增加成本,对公共资助者来说可节省成本。
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引用次数: 0
Is intracytoplasmic sperm injection an add-on to conventional in vitro fertilisation for infertility without severe male factors? 对于无严重男性因素的不孕症,卵胞浆内单精子注射是否是传统体外受精的补充?
Q4 Medicine Pub Date : 2024-06-01 DOI: 10.1136/gocm-2024-000023
Rong Li, Rui Yang
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引用次数: 0
Vaginal natural orifice transluminal endoscopic total hysterectomy (vNOTES) 阴道自然腔道内镜下全子宫切除术(vNOTES)
Q4 Medicine Pub Date : 2024-06-01 DOI: 10.1136/gocm-2024-000015
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引用次数: 0
For cervical cancer screening, which test is better, and for whom? 对于宫颈癌筛查,哪种检测方法更好?
Q4 Medicine Pub Date : 2024-06-01 DOI: 10.1136/gocm-2024-000032
Edward Mayeaux, Yun Zhao
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引用次数: 0
Assessing the treatment effect of cranberry type A proanthocyanidins on vulvovaginal candidiasis: a randomised controlled clinical interventional study 评估蔓越莓 A 型原花青素对外阴阴道念珠菌病的治疗效果:随机对照临床干预研究
Q4 Medicine Pub Date : 2024-06-01 DOI: 10.1136/gocm-2024-000014
Dongmei Wei, Yaoming Chen, Yueyue Chen, Tao Cui, Xiaoyu Niu
This study aimed to evaluate the efficacy and safety of cranberry extracts: A-type proanthocyanidins (A-PACs) in the treatment and prevention of vulvovaginal candidiasis (VVC).An open, randomised, parallel-design study was conducted. A cohort of 300 eligible patients with VVC was recruited from the hospital. All participants were randomly divided into three groups according to a computer-generated randomisation list. Patients in group 1 were treated with standard antifungal therapy (oral single-dose fluconazole 150 mg and vaginal miconazole suppository 400 mg at bedtime for 3 days); patients in group 2 received oral A-PACs 16 mL two times per day for 6 days based on the treatment regimen of group 1; patients in group 3 were given oral A-PACs 16 mL two times per day for 6 days and vaginal miconazole suppository 400 mg at bedtime for 3 days. Patients who were clinically cured at the seventh day of follow-up in group 2 received maintenance therapy by oral A-PACs for 12 weeks.At the seventh day of follow-up, the vaginal mycological results of all patients in group 2 who initially tested positive for pseudohyphae exhibited negative results. The negative conversion rates of fungal spores and blastospores in group 2 were superior to those in both group 1 and group 3. The symptoms of patients in group 2 ameliorated conspicuously compared with those in group 1 (p<0.05). The clinical cure rate of VVC in both group 2 and group 3 was not inferior to group 1. Cox regression analysis showed maintenance therapy was not significantly associated with short-term recurrence (HR 0.44 (0.11, 1.67); p=0.23) but could significantly diminish the risk of long-term recurrence (HR 0.57 (0.33, 0.99); p<0.05).This study revealed that A-PACs in cranberry juice combined with azole antibiotics can be used as a novel therapeutic option for the treatment and prevention of long-term recurrence of VVC.ChiCTR2300076392.
本研究旨在评估蔓越莓提取物 A 型原花青素(A-PACs)治疗和预防外阴阴道念珠菌病(VVC)的有效性和安全性:该研究是一项开放、随机、平行设计的研究。该研究采用随机、平行设计的方法,从医院招募了 300 名符合条件的外阴阴道念珠菌病患者。根据电脑随机生成的名单,所有参与者被随机分为三组。第一组患者接受标准抗真菌治疗(口服单剂量氟康唑 150 毫克,阴道使用咪康唑栓剂 400 毫克,睡前服用,共 3 天);第二组患者在第一组治疗方案的基础上,口服 A-PACs 16 毫升,每天 2 次,共 6 天;第三组患者口服 A-PACs 16 毫升,每天 2 次,共 6 天,阴道使用咪康唑栓剂 400 毫克,睡前服用,共 3 天。第 2 组患者在随访第 7 天时临床痊愈,接受口服 A-PACs 的维持治疗,为期 12 周。与第一组相比,第二组患者的症状明显改善(P<0.05)。Cox 回归分析显示,维持治疗与短期复发无显著相关性(HR 0.44 (0.11, 1.67); p=0.23),但可显著降低长期复发的风险(HR 0.57(0.33,0.99);P<0.05)。该研究显示,蔓越莓汁中的A-PACs与唑类抗生素联合使用,可作为治疗和预防VVC长期复发的新型治疗方案。
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引用次数: 0
Laparoscopic lateral suspension (Dubuisson) in the treatment of pelvic organ prolapse 腹腔镜侧悬吊术(杜比松)治疗盆腔脏器脱垂
Q4 Medicine Pub Date : 2024-06-01 DOI: 10.1136/gocm-2024-000010
Can Luo, Dongmei Wei, Yueyue Chen, Ling Mei, Xiaoyu Niu
Currently, the global ageing population is becoming increasingly severe, and the incidence of pelvic organ prolapse (POP) is rising year by year, which seriously impacts the psychosomatic health and the quality of life in female patients. Surgical treatments for POP still face enormous challenges.The aim of this review is to discuss the laparoscopic lateral suspension (LLS) approach to the management of POP. We use MeSH terms for each topic to retrieve relevant literature from the PubMed and Embase databases. Our group reviewed, synthesised and summarised included studies.LLS has been widely applied in the treatment of middle pelvic compartment defects. In comparison to sacrocolpopexy (SC), the most significant advantage of LLS is that it avoids dissecting the complex sacral region and possesses simple surgical procedures. But its cure, recurrence, reoperation and complication rates have been widely discussed. Issues regarding its value and its potential equivalence in surgical therapeutic effects compared with SC have gained continuous attention.Based on the existing research, LLS demonstrates advantages in the treatment of POP, particularly in cases of middle pelvic compartment defects. However, solely based on current clinical studies, it is premature to establish superiority or inferiority compared with SC. LLS is not yet a substitute for SC.
目前,全球人口老龄化日趋严重,盆腔器官脱垂(POP)的发病率逐年上升,严重影响了女性患者的心理健康和生活质量。本综述旨在讨论腹腔镜侧悬吊术(LLS)治疗 POP 的方法。我们使用 MeSH 术语对每个主题从 PubMed 和 Embase 数据库中检索相关文献。我们小组对纳入的研究进行了回顾、综合和总结。LLS已被广泛应用于中骨盆室缺损的治疗。与骶骨结节成形术(SC)相比,LLS最大的优点是避免了解剖复杂的骶骨区域,手术操作简单。但其治愈率、复发率、再次手术率和并发症发生率已引起广泛讨论。根据现有研究,LLS 在治疗 POP,尤其是中骨盆室缺损方面具有优势。然而,仅凭目前的临床研究来确定 LLS 与 SC 相比的优劣还为时过早。LLS 尚不能替代 SC。
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引用次数: 0
Relationship between the change of ATP level controlled by ectonucleotidases and endometriosis-associated infertility and pain 外切核苷酸酶控制的 ATP 水平变化与子宫内膜异位症相关不孕症和疼痛之间的关系
Q4 Medicine Pub Date : 2024-06-01 DOI: 10.1136/gocm-2024-000019
Yiling Wang, Qing-jie Zhai, Zhao Tian, Xiaohong Chang, Hong-Lan Zhu
The dysfunction of the immune system is one of the pathogeneses of endometriosis. Immune cells can not only affect the microenvironment of the endometrium by secreting cytokines and defensins but also promote angiogenesis, growth and invasion of endometrial stromal cells.ATP is a key mediator in the immune mechanism of endometriosis and plays a crucial role in endometriosis. While ATP acts as a purinergic signalling molecule, it has a close relationship with the pain of endometriosis via activating ATP receptors, including P2X3, P2X4, P2X7 and P2Y receptors, after being activated by the immune system. Besides, ATP levels reflect the impairment of mitochondrial function in granulosa cells, which could lead to infertility. The modulation of ATP expression levels is controlled by ectonucleotidases. The content of ectonucleotidases is altered in endometriosis which may be emerging non-invasive biomarkers.In the present review, we briefly introduce the relationship between the change of ATP level controlled by ectonucleotidases and endometriosis-associated infertility and pain, and illustrate our prospects for future research.
免疫系统功能失调是子宫内膜异位症的病因之一。免疫细胞不仅能通过分泌细胞因子和防御素影响子宫内膜的微环境,还能促进子宫内膜基质细胞的血管生成、生长和侵袭。ATP 是子宫内膜异位症免疫机制的关键介质,在子宫内膜异位症中起着至关重要的作用。ATP 作为一种嘌呤能信号分子,在被免疫系统激活后,通过激活 ATP 受体,包括 P2X3、P2X4、P2X7 和 P2Y 受体,与子宫内膜异位症的疼痛有着密切的关系。此外,ATP 水平反映了颗粒细胞线粒体功能的损害,从而可能导致不孕。ATP 表达水平的调节是由外切核苷酸酶控制的。在本综述中,我们简要介绍了由外切核苷酸酶控制的ATP水平变化与子宫内膜异位症相关不孕症和疼痛之间的关系,并阐述了我们对未来研究的展望。
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引用次数: 0
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Gynecology and Obstetrics Clinical Medicine
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