Pub Date : 2024-06-01DOI: 10.1136/gocm-2024-000001
I. M. Poynten, Fengyi Jin, Rhonda Farrell, Trevor Tejada-Berges, C. Law, Richard Hillman, J. Roberts, Andrew Grulich
Women diagnosed with a history of lower genital tract cancer (LGTC) and precancer are at increased risk of anal cancer. Screening for anal cancer in a manner analogous to cervical cancer may detect precursor anal high-grade squamous intraepithelial lesions (HSILs) and prevent progression to cancer.In a pilot study of anal cancer screening, women with previous LGTC and aged ≥18 years in Sydney, Australia underwent a digital anorectal examination, anal swab for human papillomavirus (HPV) and p16/Ki67 testing and completed a questionnaire. Participants with positive HPV and/or p16/Ki67 results were referred for a high-resolution anoscopy (HRA) and evaluation of their HSILs.Of 52 participants, 46 agreed to screening and 6 provided demographic information only. Median age was 46.5 years (IQR: 36.0–59.0). Anal high-risk HPV (HRHPV) was detected in only seven (15.2%) participants (three HPV16). Eight (17.4%) had positive p16/Ki67 dual staining, with invalid results for 25 (54.4%). Of 10 women referred for HRA, 9 attended and 3 had HSILs, representing 6.5% of the screened population. Questionnaires were completed by 41 participants (89.1%). The majority reported that being screened was reassuring (97.5%) and was positive for their health (95.1%).This pilot study demonstrated a lower-than-expected prevalence of anal HRHPV. Screening with HRHPV and p16/Ki67 staining identified anal HSILs in 6.5% of screened women. Despite some discomfort, screening was viewed as beneficial by almost all participants. The utility of p16/Ki67 dual staining was low, suggesting it may not be a suitable anal cancer screening methodology.
{"title":"Anal cancer screening in women with a history of human papillomavirus-related lower genital tract cancers: a pilot study","authors":"I. M. Poynten, Fengyi Jin, Rhonda Farrell, Trevor Tejada-Berges, C. Law, Richard Hillman, J. Roberts, Andrew Grulich","doi":"10.1136/gocm-2024-000001","DOIUrl":"https://doi.org/10.1136/gocm-2024-000001","url":null,"abstract":"Women diagnosed with a history of lower genital tract cancer (LGTC) and precancer are at increased risk of anal cancer. Screening for anal cancer in a manner analogous to cervical cancer may detect precursor anal high-grade squamous intraepithelial lesions (HSILs) and prevent progression to cancer.In a pilot study of anal cancer screening, women with previous LGTC and aged ≥18 years in Sydney, Australia underwent a digital anorectal examination, anal swab for human papillomavirus (HPV) and p16/Ki67 testing and completed a questionnaire. Participants with positive HPV and/or p16/Ki67 results were referred for a high-resolution anoscopy (HRA) and evaluation of their HSILs.Of 52 participants, 46 agreed to screening and 6 provided demographic information only. Median age was 46.5 years (IQR: 36.0–59.0). Anal high-risk HPV (HRHPV) was detected in only seven (15.2%) participants (three HPV16). Eight (17.4%) had positive p16/Ki67 dual staining, with invalid results for 25 (54.4%). Of 10 women referred for HRA, 9 attended and 3 had HSILs, representing 6.5% of the screened population. Questionnaires were completed by 41 participants (89.1%). The majority reported that being screened was reassuring (97.5%) and was positive for their health (95.1%).This pilot study demonstrated a lower-than-expected prevalence of anal HRHPV. Screening with HRHPV and p16/Ki67 staining identified anal HSILs in 6.5% of screened women. Despite some discomfort, screening was viewed as beneficial by almost all participants. The utility of p16/Ki67 dual staining was low, suggesting it may not be a suitable anal cancer screening methodology.","PeriodicalId":34826,"journal":{"name":"Gynecology and Obstetrics Clinical Medicine","volume":"107 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141402383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1136/gocm-2024-000017
P. Petros
{"title":"Anatomical steps in the conceptualisation of the urethral ligament plication (ULP), a tape-free operation for stress urinary incontinence (SUI) cure","authors":"P. Petros","doi":"10.1136/gocm-2024-000017","DOIUrl":"https://doi.org/10.1136/gocm-2024-000017","url":null,"abstract":"","PeriodicalId":34826,"journal":{"name":"Gynecology and Obstetrics Clinical Medicine","volume":"33 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141410718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.1136/gocm-2024-000012
Xuerun Liu, Jianliu Wang, Jingyi Zhou
Unopposed oestrogen is recognised as an inducer of endometrial cancer. Over the past 50 years, the effects of oestrogen on the endometrium and endometrial cancer have been a hot topic in the field of gynaecological oncology. In recent years, a series of studies by our team revealed that the non-genomic transcriptional effects of oestrogen can influence the progression of endometrial carcinoma by regulating calcium ions, suggesting that inhibiting calcium ion channel proteins could serve as an adjuvant therapy for endometrial cancer. In this review, we retrospectively summarise the sources of oestrogen in vivo, the effects of oestrogens on the uterus and endometrium, oestrogen signalling and the clinical application of oestrogen-related compounds, emphasising the significant role of oestrogen–calcium axis inhibition in adjuvant therapy for endometrial cancer.
{"title":"The role of oestrogen and oestrogen-calcium axis in endometrial carcinoma","authors":"Xuerun Liu, Jianliu Wang, Jingyi Zhou","doi":"10.1136/gocm-2024-000012","DOIUrl":"https://doi.org/10.1136/gocm-2024-000012","url":null,"abstract":"Unopposed oestrogen is recognised as an inducer of endometrial cancer. Over the past 50 years, the effects of oestrogen on the endometrium and endometrial cancer have been a hot topic in the field of gynaecological oncology. In recent years, a series of studies by our team revealed that the non-genomic transcriptional effects of oestrogen can influence the progression of endometrial carcinoma by regulating calcium ions, suggesting that inhibiting calcium ion channel proteins could serve as an adjuvant therapy for endometrial cancer. In this review, we retrospectively summarise the sources of oestrogen in vivo, the effects of oestrogens on the uterus and endometrium, oestrogen signalling and the clinical application of oestrogen-related compounds, emphasising the significant role of oestrogen–calcium axis inhibition in adjuvant therapy for endometrial cancer.","PeriodicalId":34826,"journal":{"name":"Gynecology and Obstetrics Clinical Medicine","volume":"283 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140779715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.1136/gocm-2024-000016
Aoxuan Zhu, Yangyang Dong, Xingchen Li, Yiqin Wang, Jianliu Wang
The International Federation of Gynecology and Obstetrics (FIGO) released a new staging for endometrial cancer (EC), which revised the FIGO2009 staging to include histopathological and molecular features. The purpose of this study was to validate the prognostic accuracy of the new staging and discuss its clinical applicability.In this single-centre retrospective study, 540 patients with primary surgically treated early-stage EC were enrolled and staged according to FIGO2009/2023. Kaplan-Meier survival analysis was used to compare for prognostic differentiation. Cox regression was used to identify potential prognostic indicators.A total of 81 patients underwent staging shifts, all stage elevation. The prognosis difference between new stages I and II was more significant. The new staging was more predictive of death postoperatively. Lesion maximum diameter (LMD) was one of the independent risk factors associated with prognosis. Taking LMD=5.70 cm as the cut-off value could further differentiate patients with divergent prognoses within FIGO2023 stage IIC.FIGO2023 staging demonstrated greater prognostic accuracy. In addition, LMD may be another critical factor affecting prognosis.
国际妇产科联盟（FIGO）发布了子宫内膜癌（EC）的新分期，对FIGO2009分期进行了修订，纳入了组织病理学和分子特征。本研究的目的是验证新分期的预后准确性，并讨论其临床适用性。在这项单中心回顾性研究中，共纳入了540例经初治手术治疗的早期EC患者，并根据FIGO2009/2023进行了分期。研究采用卡普兰-梅耶生存分析法比较预后分化。共有81名患者进行了分期转换，所有分期均升高。新分期 I 期和 II 期的预后差异更为显著。新分期更能预测术后死亡。病变最大直径（LMD）是与预后相关的独立风险因素之一。以 LMD=5.70 cm 为临界值，可以进一步区分 FIGO2023 IIC 期预后不同的患者。此外，LMD可能是影响预后的另一个关键因素。
{"title":"Rationality of the FIGO2023 staging for early-stage endometrial cancer, compared with the FIGO2009 staging","authors":"Aoxuan Zhu, Yangyang Dong, Xingchen Li, Yiqin Wang, Jianliu Wang","doi":"10.1136/gocm-2024-000016","DOIUrl":"https://doi.org/10.1136/gocm-2024-000016","url":null,"abstract":"The International Federation of Gynecology and Obstetrics (FIGO) released a new staging for endometrial cancer (EC), which revised the FIGO2009 staging to include histopathological and molecular features. The purpose of this study was to validate the prognostic accuracy of the new staging and discuss its clinical applicability.In this single-centre retrospective study, 540 patients with primary surgically treated early-stage EC were enrolled and staged according to FIGO2009/2023. Kaplan-Meier survival analysis was used to compare for prognostic differentiation. Cox regression was used to identify potential prognostic indicators.A total of 81 patients underwent staging shifts, all stage elevation. The prognosis difference between new stages I and II was more significant. The new staging was more predictive of death postoperatively. Lesion maximum diameter (LMD) was one of the independent risk factors associated with prognosis. Taking LMD=5.70 cm as the cut-off value could further differentiate patients with divergent prognoses within FIGO2023 stage IIC.FIGO2023 staging demonstrated greater prognostic accuracy. In addition, LMD may be another critical factor affecting prognosis.","PeriodicalId":34826,"journal":{"name":"Gynecology and Obstetrics Clinical Medicine","volume":"165 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140782717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aimed at developing an available predictive model of singleton pregnancies with fetal growth restriction (FGR) for accurate and individualised prognosis assessment.The prediction nomogram was developed by using multivariable Cox regression with data for 301 singleton FGR pregnancies at Peking University People’s Hospital. External validation was performed in 321 eligible singleton FGR pregnancies at the Affiliated Hospital of Qingdao University.Absent umbilical arterial flow, fetal anomaly, history of abnormal pregnancy, non-cephalic presentation and history of caesarean section were independent prognostic factors for adverse perinatal outcomes in singleton FGR pregnancies in the training set. In the training cohort of the internal validation set, the nomogram estimated pregnancy prognosis of FGR singleton pregnancies based on these five variables, with a concordance index (C-index) of 0.859 (95% CI: 0.81 to 0.90) for predicting termination of pregnancy (TOP), which included intrauterine fetal death and therapeutic lethal induction, with a C-index of 0.92 (95% CI: 0.86 to 0.98) for predicting stillbirth, and a C-index of 0.87 (95% CI: 0.83 to 0.92) for predicting therapeutic lethal induction with indications. Encouragingly, consistent results were observed in the external validation set, with a C-index of 0.776 (95% CI: 0.71 to 0.84) for predicting TOP, which included intrauterine fetal death and therapeutic lethal induction, with a C-index of 0.773 (95% CI: 0.70 to 0.84) for predicting stillbirth, and a C-index of 0.776 (95% CI: 0.70 to 0.85) for predicting therapeutic lethal induction with indications. Furthermore, the calibrations of the nomograms predicting the 28th and 34th TOP-free gestation week strongly corresponded to the actual survival outcome.This prediction model may help clinicians in decision-making for singleton pregnancies with FGR, especially for patients with a single abnormal umbilical arterial flow or fetal anomaly, without induced labour indications for these abnormalities.
{"title":"Externally validated nomogram for predicting short-term pregnancy outcome of singleton pregnancies with fetal growth restriction (FGR)","authors":"Fufen Yin, Mingrui Jin, Yujing Li, Yang Li, Xiuju Yin, Junshu Xie, Xiaohong Zhang","doi":"10.1136/gocm-2024-000009","DOIUrl":"https://doi.org/10.1136/gocm-2024-000009","url":null,"abstract":"This study aimed at developing an available predictive model of singleton pregnancies with fetal growth restriction (FGR) for accurate and individualised prognosis assessment.The prediction nomogram was developed by using multivariable Cox regression with data for 301 singleton FGR pregnancies at Peking University People’s Hospital. External validation was performed in 321 eligible singleton FGR pregnancies at the Affiliated Hospital of Qingdao University.Absent umbilical arterial flow, fetal anomaly, history of abnormal pregnancy, non-cephalic presentation and history of caesarean section were independent prognostic factors for adverse perinatal outcomes in singleton FGR pregnancies in the training set. In the training cohort of the internal validation set, the nomogram estimated pregnancy prognosis of FGR singleton pregnancies based on these five variables, with a concordance index (C-index) of 0.859 (95% CI: 0.81 to 0.90) for predicting termination of pregnancy (TOP), which included intrauterine fetal death and therapeutic lethal induction, with a C-index of 0.92 (95% CI: 0.86 to 0.98) for predicting stillbirth, and a C-index of 0.87 (95% CI: 0.83 to 0.92) for predicting therapeutic lethal induction with indications. Encouragingly, consistent results were observed in the external validation set, with a C-index of 0.776 (95% CI: 0.71 to 0.84) for predicting TOP, which included intrauterine fetal death and therapeutic lethal induction, with a C-index of 0.773 (95% CI: 0.70 to 0.84) for predicting stillbirth, and a C-index of 0.776 (95% CI: 0.70 to 0.85) for predicting therapeutic lethal induction with indications. Furthermore, the calibrations of the nomograms predicting the 28th and 34th TOP-free gestation week strongly corresponded to the actual survival outcome.This prediction model may help clinicians in decision-making for singleton pregnancies with FGR, especially for patients with a single abnormal umbilical arterial flow or fetal anomaly, without induced labour indications for these abnormalities.","PeriodicalId":34826,"journal":{"name":"Gynecology and Obstetrics Clinical Medicine","volume":"41 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140759505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.1136/gocm-2024-000011
S. Dutta, P. Sengupta, Fong Fong Liew
Synchronised physiological adaptations occur during pregnancy to achieve systemic, immune and neuroendocrine equilibrium in the mother’s body, allowing semiallogenic fetal growth.Depending on the cytokine profile alterations occurring through pregnancy, the latter can be divided into three distinct phases. In the first immunological phase of pregnancy, proinflammatory cytokines promote inflammatory reactions needed for implantation. In the second phase, a possible change from proinflammatory to anti-inflammatory cytokines creates a symbiosis between maternal and fetal components, ensuring fetal development. In the third phase, inflammatory and cytolytic cytokines operate again to reinforce an inflammatory environment for parturition. The article offers a detailed account of immune adaptations during pregnancy and highlights the distinctive cytokine profiles that mark each phase.By providing a simplified depiction of pregnancy phases based on cytokine profiles, the article aims to inspire more research in reproductive immunology and improve the management of pregnancy-related inflammation and infection.
{"title":"Cytokine landscapes of pregnancy: mapping gestational immune phases","authors":"S. Dutta, P. Sengupta, Fong Fong Liew","doi":"10.1136/gocm-2024-000011","DOIUrl":"https://doi.org/10.1136/gocm-2024-000011","url":null,"abstract":"Synchronised physiological adaptations occur during pregnancy to achieve systemic, immune and neuroendocrine equilibrium in the mother’s body, allowing semiallogenic fetal growth.Depending on the cytokine profile alterations occurring through pregnancy, the latter can be divided into three distinct phases. In the first immunological phase of pregnancy, proinflammatory cytokines promote inflammatory reactions needed for implantation. In the second phase, a possible change from proinflammatory to anti-inflammatory cytokines creates a symbiosis between maternal and fetal components, ensuring fetal development. In the third phase, inflammatory and cytolytic cytokines operate again to reinforce an inflammatory environment for parturition. The article offers a detailed account of immune adaptations during pregnancy and highlights the distinctive cytokine profiles that mark each phase.By providing a simplified depiction of pregnancy phases based on cytokine profiles, the article aims to inspire more research in reproductive immunology and improve the management of pregnancy-related inflammation and infection.","PeriodicalId":34826,"journal":{"name":"Gynecology and Obstetrics Clinical Medicine","volume":"180 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140788159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.1136/gocm-2024-000006
Yi Ling Wang, Xin Lei Lu, Shang Wang, Xiao Hong Chang, Rong Zhang, Hong-Lan Zhu
Pelvic pain is a common complaint of discomfort in women, with an increasing incidence and seriously affecting patients’ quality of life. Its etiology involves multiple systems and disciplines, and therefore treatment modalities are diverse. Transcutaneous electrical acupoint stimulation (TEAS) therapy is a classic analgesic means, and electrical stimulation of local acupoints can achieve obvious analgesic effects. This review aims to discuss the application of TEAS for the treatment of various types of pelvic pain, the selection of optimal parameters and the renewal of equipment.TEAS for treatment of pelvic pain in women has been reported mainly for endometriosis, pelvic inflammatory disease (PID), intrauterine adhesion (IUA), pelvic stasis syndrome, interstitial cystitis, primary dysmenorrhoea and other diseases. And for parameter selection, the most used of frequency is dilatational wave, the most used stimulation intensity is 10–20 mA, and the acupoint selection should be based on the specific conditions of the patient.The analgesic mechanism of TEAS has not been fully elucidated, but the efficacy of the treatment is remarkable and there are no significant adverse effects. The selection of the parameters for TEAS and the combination of acupoints for different pains are still the main directions of future research.
{"title":"Advancements in research on transcutaneous electrical acupoint stimulation for alleviating pelvic pain in women","authors":"Yi Ling Wang, Xin Lei Lu, Shang Wang, Xiao Hong Chang, Rong Zhang, Hong-Lan Zhu","doi":"10.1136/gocm-2024-000006","DOIUrl":"https://doi.org/10.1136/gocm-2024-000006","url":null,"abstract":"Pelvic pain is a common complaint of discomfort in women, with an increasing incidence and seriously affecting patients’ quality of life. Its etiology involves multiple systems and disciplines, and therefore treatment modalities are diverse. Transcutaneous electrical acupoint stimulation (TEAS) therapy is a classic analgesic means, and electrical stimulation of local acupoints can achieve obvious analgesic effects. This review aims to discuss the application of TEAS for the treatment of various types of pelvic pain, the selection of optimal parameters and the renewal of equipment.TEAS for treatment of pelvic pain in women has been reported mainly for endometriosis, pelvic inflammatory disease (PID), intrauterine adhesion (IUA), pelvic stasis syndrome, interstitial cystitis, primary dysmenorrhoea and other diseases. And for parameter selection, the most used of frequency is dilatational wave, the most used stimulation intensity is 10–20 mA, and the acupoint selection should be based on the specific conditions of the patient.The analgesic mechanism of TEAS has not been fully elucidated, but the efficacy of the treatment is remarkable and there are no significant adverse effects. The selection of the parameters for TEAS and the combination of acupoints for different pains are still the main directions of future research.","PeriodicalId":34826,"journal":{"name":"Gynecology and Obstetrics Clinical Medicine","volume":"48 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140760694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.1136/gocm-2024-000018
Lili Xing, Lianhua Bai, Sen Li, Jingjing Gong, Xiaoting Wei, Lei Liu, Ting Chen, Xiaodan Li
To understand the current level of social alienation among patients with stress urinary incontinence (SUI) and analyse the influencing factors to provide a foundation for better clinical support for patients’ reintegration into society.We conducted a comprehensive survey and analysis involving 230 patients with SUI using a general information questionnaire, a general sense of alienation scale and a social impact scale.The general sense of alienation scale score of patients with SUI was 25.43±13.994, while the social impact score was 39.25±12.167. Multiple linear regression analysis revealed that marital status, primary caregiver, presence of concurrent illnesses and severity of urinary incontinence were the key influencing factors contributing to SUI-related social alienation (p<0.05).Patients who suffered from SUI experienced a moderate level of social alienation. Tailored interventions are recommended, especially for individuals who are divorced, rely on friends or relatives as primary caregivers, have concurrent illnesses or experience severe SUI, to enhance their social integration.
我们使用一般信息问卷、一般疏离感量表和社会影响量表对230名压力性尿失禁（SUI）患者进行了全面调查和分析，SUI患者的一般疏离感量表得分为（25.43±13.994）分，社会影响量表得分为（39.25±12.167）分。多元线性回归分析显示，婚姻状况、主要照顾者、是否患有并发症以及尿失禁的严重程度是导致 SUI 相关社会疏离感的主要影响因素（P<0.05）。建议采取有针对性的干预措施，尤其是针对离异、依赖亲友作为主要照顾者、患有并发症或严重尿失禁的患者，以加强他们的社会融合。
{"title":"Current state and influencing factors of social alienation in patients with stress urinary incontinence","authors":"Lili Xing, Lianhua Bai, Sen Li, Jingjing Gong, Xiaoting Wei, Lei Liu, Ting Chen, Xiaodan Li","doi":"10.1136/gocm-2024-000018","DOIUrl":"https://doi.org/10.1136/gocm-2024-000018","url":null,"abstract":"To understand the current level of social alienation among patients with stress urinary incontinence (SUI) and analyse the influencing factors to provide a foundation for better clinical support for patients’ reintegration into society.We conducted a comprehensive survey and analysis involving 230 patients with SUI using a general information questionnaire, a general sense of alienation scale and a social impact scale.The general sense of alienation scale score of patients with SUI was 25.43±13.994, while the social impact score was 39.25±12.167. Multiple linear regression analysis revealed that marital status, primary caregiver, presence of concurrent illnesses and severity of urinary incontinence were the key influencing factors contributing to SUI-related social alienation (p<0.05).Patients who suffered from SUI experienced a moderate level of social alienation. Tailored interventions are recommended, especially for individuals who are divorced, rely on friends or relatives as primary caregivers, have concurrent illnesses or experience severe SUI, to enhance their social integration.","PeriodicalId":34826,"journal":{"name":"Gynecology and Obstetrics Clinical Medicine","volume":"46 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140767218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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