首页 > 最新文献

Clinical Dermatology Review最新文献

英文 中文
Holistic approach to management of acne: Exploring the evidence 痤疮的整体管理方法:探索证据
Pub Date : 2023-07-01 DOI: 10.4103/cdr.cdr_56_21
Sujata R Mehta Ambalal
A shift in the understanding of acne from a skin disease to a systemic, chronic inflammatory, lifestyle disease has fueled our curiosity about holistic ways to manage it. As with other noncommunicable diseases, long-term management needs a comprehensive approach. Apart from topical and systemic medications, changes in diet and lifestyle can help us achieve superior and long-lasting results. Moreover, as the biochemical pathways linking risk factors to acne are getting clearer, the potential prospect of early holistic management of acne preventing or delaying other lifestyle disorders such as obesity, diabetes, or cardiovascular disease is encouraging.
人们对痤疮的认识从一种皮肤病转变为一种全身性、慢性炎症性、生活方式性疾病,这激发了我们对全面治疗痤疮的好奇心。与其他非传染性疾病一样,长期管理需要采取综合办法。除了局部和全身的药物治疗,饮食和生活方式的改变可以帮助我们获得更好的和持久的效果。此外,随着与痤疮风险因素相关的生化途径越来越清晰,痤疮早期整体管理预防或延缓其他生活方式失调(如肥胖、糖尿病或心血管疾病)的潜在前景令人鼓舞。
{"title":"Holistic approach to management of acne: Exploring the evidence","authors":"Sujata R Mehta Ambalal","doi":"10.4103/cdr.cdr_56_21","DOIUrl":"https://doi.org/10.4103/cdr.cdr_56_21","url":null,"abstract":"A shift in the understanding of acne from a skin disease to a systemic, chronic inflammatory, lifestyle disease has fueled our curiosity about holistic ways to manage it. As with other noncommunicable diseases, long-term management needs a comprehensive approach. Apart from topical and systemic medications, changes in diet and lifestyle can help us achieve superior and long-lasting results. Moreover, as the biochemical pathways linking risk factors to acne are getting clearer, the potential prospect of early holistic management of acne preventing or delaying other lifestyle disorders such as obesity, diabetes, or cardiovascular disease is encouraging.","PeriodicalId":34880,"journal":{"name":"Clinical Dermatology Review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45273803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A clinicopathological study of polymorphous light eruption 多形性轻疹的临床病理研究
Pub Date : 2023-07-01 DOI: 10.4103/cdr.cdr_110_21
N. Patil, A. Bubna, Maharaja Krishnamoorthy, L. Joseph
Background: Polymorphous light eruption (PLE) is the most common idiopathic photodermatoses, with a wide range of clinical presentations that tends to mimic a number of dermatoses. Objective: The aim was to study the clinicopathological profile in patients diagnosed with PLE. Materials and Methods: This was a cross-sectional, descriptive study of seventy clinically diagnosed cases of PLE over a period of 1 year, wherein following patient enrolment, they underwent a thorough clinical evaluation, followed by a skin biopsy that was studied categorically. Results: A male preponderance (62.8%) was observed. Majority of patients were in the 21-30 years' age group (28.6%). Pruritus was witnessed in 98.5% of patients. The most common morphological type encountered was plaque PLE (35.7%), followed by lichen nitidus type (11.4%). Commonest site of involvement was sides and back of neck (75.7%), followed by dorsolateral aspect of both arms (31.4%). Hyperkeratosis was identified in 82.8%, spongiosis in 87.1%, liquefactive degeneration of basal cell layer in 82.8%, atrophy in 24.2%, and moderate-to-severe lymphocytic dermal infiltrates in 90% of our cohorts. Conclusion: PLE is a disorder with diverse clinical presentations, manifesting usually in the third decade of life that closely mimics a variety of other cutaneous disorders. Histological examination with certain specific criteria enables the clinician to arrive at a concrete conclusion in those cases where clinical findings alone pose diagnostic difficulties.
背景:多形性光疹(PLE)是最常见的特发性光损伤性疾病,临床表现广泛,往往与多种皮肤病相似。目的:研究诊断为PLE的患者的临床病理特征。材料和方法:这是一项在一年内对70例临床诊断的PLE病例进行的横断面描述性研究,其中在患者入组后,他们接受了彻底的临床评估,然后进行了明确研究的皮肤活检。结果:男性占优势(62.8%)。大多数患者在21-30岁年龄组(28.6%)。98.5%的患者出现瘙痒。最常见的形态类型是斑块PLE(35.7%),其次是nitidus型地衣(11.4%)。最常见的受累部位是颈部两侧和后部(75.7%),然后是双臂背外侧(31.4%)。角化过度占82.8%,海绵状血管病占87.1%,基底细胞层液化性变性占82.8%。萎缩占24.2%,在我们90%的队列中有中度至重度淋巴细胞性真皮浸润。结论:PLE是一种临床表现多样的疾病,通常在生命的第三个十年表现出来,与其他各种皮肤疾病非常相似。具有某些特定标准的组织学检查使临床医生能够在仅凭临床发现造成诊断困难的情况下得出具体结论。
{"title":"A clinicopathological study of polymorphous light eruption","authors":"N. Patil, A. Bubna, Maharaja Krishnamoorthy, L. Joseph","doi":"10.4103/cdr.cdr_110_21","DOIUrl":"https://doi.org/10.4103/cdr.cdr_110_21","url":null,"abstract":"Background: Polymorphous light eruption (PLE) is the most common idiopathic photodermatoses, with a wide range of clinical presentations that tends to mimic a number of dermatoses. Objective: The aim was to study the clinicopathological profile in patients diagnosed with PLE. Materials and Methods: This was a cross-sectional, descriptive study of seventy clinically diagnosed cases of PLE over a period of 1 year, wherein following patient enrolment, they underwent a thorough clinical evaluation, followed by a skin biopsy that was studied categorically. Results: A male preponderance (62.8%) was observed. Majority of patients were in the 21-30 years' age group (28.6%). Pruritus was witnessed in 98.5% of patients. The most common morphological type encountered was plaque PLE (35.7%), followed by lichen nitidus type (11.4%). Commonest site of involvement was sides and back of neck (75.7%), followed by dorsolateral aspect of both arms (31.4%). Hyperkeratosis was identified in 82.8%, spongiosis in 87.1%, liquefactive degeneration of basal cell layer in 82.8%, atrophy in 24.2%, and moderate-to-severe lymphocytic dermal infiltrates in 90% of our cohorts. Conclusion: PLE is a disorder with diverse clinical presentations, manifesting usually in the third decade of life that closely mimics a variety of other cutaneous disorders. Histological examination with certain specific criteria enables the clinician to arrive at a concrete conclusion in those cases where clinical findings alone pose diagnostic difficulties.","PeriodicalId":34880,"journal":{"name":"Clinical Dermatology Review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47507864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinico-mycological profile of recurrent dermatophytosis with drug sensitivity in a tertiary care center in Southern Odisha 奥里萨邦南部三级保健中心复发性皮肤癣药敏的临床-真菌学分析
Pub Date : 2023-07-01 DOI: 10.4103/cdr.cdr_58_22
Ramachandran Gnanasuriyan, Satyadarshi Patnaik, S. Patro, I. Mohanty
Background: Recurrent dermatophytosis is a pressing problem worldwide due to inadequate treatment, drug resistance, and indiscriminate use of topical steroids. This scenario increases the need for the study of risk factors and antifungal susceptibility testing. There is a paucity of information on this subject. Objective: We aimed to find the clinico-mycological pattern of recurrent dermatophytic infections, the factors responsible for recurrence and determine the sensitivity pattern of isolates against four antifungals (fluconazole, itraconazole, terbinafine, and amphotericin B). Materials and Methods: Patients with recurrent dermatophytosis attending the outpatient Department of Our Tertiary Care Institute were enrolled in this study. A detailed history was taken; clinical examination was done; samples were collected for mycological examinations, and in-vitro antifungal sensitivity testing was done by broth microdilution method as per Clinical and Laboratory Standard Institute M38-A guidelines. Results: One hundred and twenty-eight patients were included in the study with a male:female ratio of 1.38:1. The most commonly affected age group was 31–40 years. Tinea corporis with tinea cruris was the most common type of clinical presentation. Potassium hydroxide mount was positive in 53 samples and culture was positive in 59 samples. Trichophyton rubrum was the predominant species isolated, followed by Trichophyton mentagrophytes. On in-vitro antifungal susceptibility testing, itraconazole and amphotericin B had the lowest minimum inhibitory concentrations (MIC), followed by terbinafine. Fluconazole had the highest MIC among the drugs tested. Conclusion: Topical corticosteroid abuse, lack of personal hygiene, and habit of sharing clothes were seen in many patients with recalcitrant dermatophytosis. T. rubrum was the most common isolated species. Antifungal susceptibility testing revealed itraconazole and amphotericin B to have the lowest MIC value and fluconazole to have the highest MIC value.
背景:由于治疗不充分、耐药和滥用局部类固醇,复发性皮肤癣是世界范围内一个紧迫的问题。这种情况增加了研究危险因素和抗真菌药敏试验的需要。关于这个问题的资料很少。目的:探讨复发性皮肤真菌感染的临床-真菌学特征及引起复发的因素,确定分离物对氟康唑、伊曲康唑、特比萘芬、两性霉素B等4种抗真菌药物的敏感性。材料与方法:选取我院三级保健所门诊的复发性皮肤真菌患者。记录了详细的历史;完成临床检查;采集样品进行真菌学检查,并按照临床和实验室标准协会M38-A指南,用肉汤微量稀释法进行体外抗真菌敏感性试验。结果:共纳入128例患者,男女比例为1.38:1。最常见的发病年龄为31-40岁。体癣合并股癣是最常见的临床表现。53份样品氢氧化钾mount阳性,59份样品培养阳性。分离到的优势种为红毛癣菌,其次为毛癣菌。体外抗真菌药敏试验中,伊曲康唑和两性霉素B的最低抑菌浓度(MIC)最低,特比萘芬次之。氟康唑的MIC最高。结论:顽固性皮癣患者滥用皮质类固醇、缺乏个人卫生和共用衣服的习惯较多。红绒毡虫是最常见的分离种。抗真菌药敏试验显示,伊曲康唑和两性霉素B的MIC值最低,氟康唑的MIC值最高。
{"title":"Clinico-mycological profile of recurrent dermatophytosis with drug sensitivity in a tertiary care center in Southern Odisha","authors":"Ramachandran Gnanasuriyan, Satyadarshi Patnaik, S. Patro, I. Mohanty","doi":"10.4103/cdr.cdr_58_22","DOIUrl":"https://doi.org/10.4103/cdr.cdr_58_22","url":null,"abstract":"Background: Recurrent dermatophytosis is a pressing problem worldwide due to inadequate treatment, drug resistance, and indiscriminate use of topical steroids. This scenario increases the need for the study of risk factors and antifungal susceptibility testing. There is a paucity of information on this subject. Objective: We aimed to find the clinico-mycological pattern of recurrent dermatophytic infections, the factors responsible for recurrence and determine the sensitivity pattern of isolates against four antifungals (fluconazole, itraconazole, terbinafine, and amphotericin B). Materials and Methods: Patients with recurrent dermatophytosis attending the outpatient Department of Our Tertiary Care Institute were enrolled in this study. A detailed history was taken; clinical examination was done; samples were collected for mycological examinations, and in-vitro antifungal sensitivity testing was done by broth microdilution method as per Clinical and Laboratory Standard Institute M38-A guidelines. Results: One hundred and twenty-eight patients were included in the study with a male:female ratio of 1.38:1. The most commonly affected age group was 31–40 years. Tinea corporis with tinea cruris was the most common type of clinical presentation. Potassium hydroxide mount was positive in 53 samples and culture was positive in 59 samples. Trichophyton rubrum was the predominant species isolated, followed by Trichophyton mentagrophytes. On in-vitro antifungal susceptibility testing, itraconazole and amphotericin B had the lowest minimum inhibitory concentrations (MIC), followed by terbinafine. Fluconazole had the highest MIC among the drugs tested. Conclusion: Topical corticosteroid abuse, lack of personal hygiene, and habit of sharing clothes were seen in many patients with recalcitrant dermatophytosis. T. rubrum was the most common isolated species. Antifungal susceptibility testing revealed itraconazole and amphotericin B to have the lowest MIC value and fluconazole to have the highest MIC value.","PeriodicalId":34880,"journal":{"name":"Clinical Dermatology Review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42999160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A cross-sectional survey to evaluate the influence of the COVID-19 pandemic on treatment adherence in chronic dermatological diseases 评估新冠肺炎大流行对慢性皮肤病治疗依从性影响的横断面调查
Pub Date : 2023-07-01 DOI: 10.4103/cdr.cdr_32_21
P. Patil, Vishalakshi Viswanath, P. R. Joshi, M. Dhakne
Background: The COVID-19 pandemic and subsequent nationwide lockdowns have contributed to complex problems in the management of chronic dermatological diseases. Objectives: The objective of this study is to evaluate the impact of the COVID-19 pandemic on the management of chronic dermatological diseases treated with/without systemic immunomodulators and phototherapy. Materials and Methods: A single-center, cross-sectional, questionnaire-based survey via telephone calls/Google Forms was conducted from May 2020 to July 2020. Multivariate correlation analysis with adherence to treatment as dependent variable was performed to study the influence of various demographic variables, treatment-related factors, and pandemic issues. Results: Data of 138 patients (55% with psoriasis, 21% with vesiculobullous diseases, 18.2% with connective tissue diseases, and 5.8% with conditions such as alopecia areata, vitiligo, lichen planus, and reactive arthritis) were analyzed. The study population consisted of 81.1% of patients on systemic immunomodulators. Autonomous treatment modification was reported by 77% leading to poor disease control in 53.7%. There was a statistically significant negative correlation between income loss during the pandemic and treatment adherence. Duration of illness also showed a significant negative correlation, thereby indicating that treatment adherence reduced with disease chronicity. The highest nonadherence was noted with apremilast. None of the patients reported confirmed COVID infection. Conclusions: The study findings emphasize the direct and indirect effects of the COVID-19 pandemic on treatment adherence in chronic dermatological diseases. It underlines the need for better pandemic response by the development of patient education programs, standard protocols, and functional teledermatology units in Indian public health-care settings.
背景:新冠肺炎大流行和随后的全国封锁导致了慢性皮肤病管理方面的复杂问题。目的:本研究的目的是评估新冠肺炎大流行对使用/不使用全身免疫调节剂和光疗治疗的慢性皮肤病管理的影响。材料和方法:2020年5月至2020年7月,通过电话/谷歌表格进行了一项单中心、横断面、问卷调查。以坚持治疗为因变量进行多变量相关性分析,以研究各种人口统计学变量、治疗相关因素和流行病问题的影响。结果:分析了138名患者的数据(55%的患者患有银屑病,21%的患者患有水疱性大疱性疾病,18.2%的患者患有结缔组织疾病,5.8%的患者伴有斑秃、白癜风、扁平苔藓和反应性关节炎)。研究人群包括81.1%的使用全身免疫调节剂的患者。77%的人报告说,自主治疗的改变导致53.7%的人疾病控制不佳。疫情期间的收入损失与治疗依从性之间存在统计学上显著的负相关。疾病持续时间也显示出显著的负相关,从而表明治疗依从性随着疾病的慢性性而降低。不依从性最高的是阿哌拉司特。没有一名患者报告确诊感染了新冠肺炎。结论:研究结果强调了新冠肺炎大流行对慢性皮肤病治疗依从性的直接和间接影响。它强调了通过在印度公共医疗机构制定患者教育计划、标准协议和功能性远程皮肤科来更好地应对疫情的必要性。
{"title":"A cross-sectional survey to evaluate the influence of the COVID-19 pandemic on treatment adherence in chronic dermatological diseases","authors":"P. Patil, Vishalakshi Viswanath, P. R. Joshi, M. Dhakne","doi":"10.4103/cdr.cdr_32_21","DOIUrl":"https://doi.org/10.4103/cdr.cdr_32_21","url":null,"abstract":"Background: The COVID-19 pandemic and subsequent nationwide lockdowns have contributed to complex problems in the management of chronic dermatological diseases. Objectives: The objective of this study is to evaluate the impact of the COVID-19 pandemic on the management of chronic dermatological diseases treated with/without systemic immunomodulators and phototherapy. Materials and Methods: A single-center, cross-sectional, questionnaire-based survey via telephone calls/Google Forms was conducted from May 2020 to July 2020. Multivariate correlation analysis with adherence to treatment as dependent variable was performed to study the influence of various demographic variables, treatment-related factors, and pandemic issues. Results: Data of 138 patients (55% with psoriasis, 21% with vesiculobullous diseases, 18.2% with connective tissue diseases, and 5.8% with conditions such as alopecia areata, vitiligo, lichen planus, and reactive arthritis) were analyzed. The study population consisted of 81.1% of patients on systemic immunomodulators. Autonomous treatment modification was reported by 77% leading to poor disease control in 53.7%. There was a statistically significant negative correlation between income loss during the pandemic and treatment adherence. Duration of illness also showed a significant negative correlation, thereby indicating that treatment adherence reduced with disease chronicity. The highest nonadherence was noted with apremilast. None of the patients reported confirmed COVID infection. Conclusions: The study findings emphasize the direct and indirect effects of the COVID-19 pandemic on treatment adherence in chronic dermatological diseases. It underlines the need for better pandemic response by the development of patient education programs, standard protocols, and functional teledermatology units in Indian public health-care settings.","PeriodicalId":34880,"journal":{"name":"Clinical Dermatology Review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47872140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Estimation of hair cortisol levels as a biomarker of chronic stress in psoriasis: A pilot study 估计头发皮质醇水平作为牛皮癣慢性应激的生物标志物:一项初步研究
Pub Date : 2023-07-01 DOI: 10.4103/cdr.cdr_27_22
L. Budamakuntla, E. Loganathan, Heera Ramesh, Priyanka Karagaiah, S. Somashekhar, Shankar Kumar Venkatarayaraju
Background: Psychological stress can exacerbate many inflammatory diseases like psoriasis by dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis. One method of establishing this correlation is by measuring cortisol levels. Deposition of cortisol in the hair during its growth allows for retrospective quantification and to analyze the relationship between hair cortisol levels, stress, and psoriasis. Objective: The objective of this study is to evaluate hair cortisol levels as a biomarker of chronic stress in psoriasis patients. Materials and Methods: Detailed clinical and personal history and stress-related events before the onset of the disease or any exacerbations during the disease were taken. Clinical severity was assessed using psoriasis area and severity index (PASI) scoring. Stress levels in individuals, during the previous 6 months were assessed, using Holmes–Rahe Life Stress Inventory. Following this, hair samples were collected from the vertex of the scalp and sent to the laboratory in an envelope. After extraction of the cortisol, their levels were estimated using an enzyme-linked immunosorbent assay. Statistical analyses were done. Results: Mean hair cortisol level per mg of hair sample was 0.92 ± 0.84 ng/mg compared to 0.50 ± 0.60 ng/mg in controls (P = 0.002). There was a significant positive correlation of hair cortisol levels with the duration of disease, PASI score, and stress level. Conclusion: Measurement of cortisol in hair is a novel, noninvasive method that may assess systemic cortisol levels over several weeks to months. It may potentially be used as a biomarker in psychocutaneous disorders like psoriasis.
背景:心理应激可通过调节下丘脑-垂体-肾上腺(HPA)轴而使银屑病等炎症性疾病恶化。建立这种相关性的一种方法是测量皮质醇水平。毛发生长过程中皮质醇的沉积可以进行回顾性量化,并分析毛发皮质醇水平、压力和牛皮癣之间的关系。目的:本研究的目的是评估毛发皮质醇水平作为银屑病患者慢性应激的生物标志物。材料和方法:详细的临床和个人病史以及发病前或疾病期间任何恶化的压力相关事件。采用银屑病面积和严重程度指数(PASI)评分评估临床严重程度。使用Holmes-Rahe生活压力量表评估个体在前6个月的压力水平。在此之后,从头皮顶点收集头发样本,并将其装在信封里送到实验室。提取皮质醇后,使用酶联免疫吸附法估计其水平。进行了统计分析。结果:毛发样本的平均皮质醇水平为0.92±0.84 ng/mg,对照组为0.50±0.60 ng/mg (P = 0.002)。毛发皮质醇水平与病程、PASI评分和应激水平呈正相关。结论:测量头发中的皮质醇是一种新颖的、无创的方法,可以评估几周到几个月的全身皮质醇水平。它可能被用作牛皮癣等精神皮肤疾病的生物标志物。
{"title":"Estimation of hair cortisol levels as a biomarker of chronic stress in psoriasis: A pilot study","authors":"L. Budamakuntla, E. Loganathan, Heera Ramesh, Priyanka Karagaiah, S. Somashekhar, Shankar Kumar Venkatarayaraju","doi":"10.4103/cdr.cdr_27_22","DOIUrl":"https://doi.org/10.4103/cdr.cdr_27_22","url":null,"abstract":"Background: Psychological stress can exacerbate many inflammatory diseases like psoriasis by dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis. One method of establishing this correlation is by measuring cortisol levels. Deposition of cortisol in the hair during its growth allows for retrospective quantification and to analyze the relationship between hair cortisol levels, stress, and psoriasis. Objective: The objective of this study is to evaluate hair cortisol levels as a biomarker of chronic stress in psoriasis patients. Materials and Methods: Detailed clinical and personal history and stress-related events before the onset of the disease or any exacerbations during the disease were taken. Clinical severity was assessed using psoriasis area and severity index (PASI) scoring. Stress levels in individuals, during the previous 6 months were assessed, using Holmes–Rahe Life Stress Inventory. Following this, hair samples were collected from the vertex of the scalp and sent to the laboratory in an envelope. After extraction of the cortisol, their levels were estimated using an enzyme-linked immunosorbent assay. Statistical analyses were done. Results: Mean hair cortisol level per mg of hair sample was 0.92 ± 0.84 ng/mg compared to 0.50 ± 0.60 ng/mg in controls (P = 0.002). There was a significant positive correlation of hair cortisol levels with the duration of disease, PASI score, and stress level. Conclusion: Measurement of cortisol in hair is a novel, noninvasive method that may assess systemic cortisol levels over several weeks to months. It may potentially be used as a biomarker in psychocutaneous disorders like psoriasis.","PeriodicalId":34880,"journal":{"name":"Clinical Dermatology Review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47517913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A cross-sectional study of dermatologic manifestations in patients with chronic renal failure on hemodialysis 血液透析中慢性肾功能衰竭患者皮肤病表现的横断面研究
Pub Date : 2023-07-01 DOI: 10.4103/cdr.cdr_37_22
Indira Potthuri, Inamadar C. Arun
Background: Chronic renal failure patients undergoing dialysis suffer from various side effects and complications where skin ailments are one of them. Skin is the largest and one of the most dynamic organs of the body and can be used as a window since it is easily accessible for observation and reflects changes seen in multiple organs including kidneys. Objective: The objective of this study is to describe various cutaneous manifestations in chronic kidney disease patients undergoing hemodialysis. Materials and Methods: A hospital-based, cross-sectional, observational study was conducted in the department of dermatology, venereology, and leprosy at a tertiary care center from November 2019 to May 2021. The demographic details and clinical manifestations were recorded. Data were recorded as numbers and percentages. For categorical data, the number and percentage were used in the data summaries, and data were analyzed by the Mann‒Whitney U test for the comparison of two data. Results: A total of 94 patients were included in the study. The most common manifestation observed was pruritus (85.1%), followed by xerosis (84%). Other findings seen in the study were mainly nonspecific changes such as pallor (59.57%), diffuse hyperpigmentation (3.2%), and ecchymosis (16%). Nail changes (56.38%) observed were half-and-half nails (22.6%), onycholysis (11%), and Beau's lines (9%). Mucosal changes (36.17%) included depapillated tongue (12.8%) and macroglossia (8.5%). Other findings such as skin infections and keloid were also noted. New finding such as angina bullosa hemorrhagica was seen in one patient. Specific change like Kyrle's disease was seen in 6.4% of the study group and 50% of these patients had concomitant diabetes mellitus. Conclusion: Patients on hemodialysis present with an array of cutaneous manifestations. The most common include pruritus and xerosis. Prompt diagnosis and early treatment help alleviate many of the cutaneous manifestations posed due to hemodialysis.
背景:接受透析的慢性肾功能衰竭患者会出现各种副作用和并发症,皮肤病就是其中之一。皮肤是身体最大、最具活力的器官之一,可以用作一个窗口,因为它很容易观察,并反映包括肾脏在内的多个器官的变化。目的:本研究的目的是描述接受血液透析的慢性肾脏病患者的各种皮肤表现。材料和方法:2019年11月至2021年5月,在一家三级护理中心的皮肤科、性病科和麻风病科进行了一项基于医院的横断面观察性研究。记录人口统计学细节和临床表现。数据记录为数字和百分比。对于分类数据,数据摘要中使用了数字和百分比,并通过Mann-Whitney U检验对数据进行分析,以比较两个数据。结果:共有94名患者被纳入研究。最常见的表现是瘙痒(85.1%),其次是干燥症(84%)。研究中的其他发现主要是非特异性变化,如苍白(59.57%)、弥漫性色素沉着(3.2%)和瘀斑(16%)。观察到的指甲变化(56.38%)为半指甲和半指甲(22.6%)、甲裂(11%)和博氏线(9%)。粘膜变化(36.17%)包括舌尖脱落(12.8%)和巨舌症(8.5%)。其他发现如皮肤感染和瘢痕疙瘩。一名患者出现新的发现,如出血性大疱性心绞痛。6.4%的研究组患者出现了类似Kyrle病的特殊变化,其中50%的患者伴有糖尿病。结论:血液透析患者有一系列的皮肤表现。最常见的包括瘙痒和干燥。及时诊断和早期治疗有助于缓解血液透析引起的许多皮肤表现。
{"title":"A cross-sectional study of dermatologic manifestations in patients with chronic renal failure on hemodialysis","authors":"Indira Potthuri, Inamadar C. Arun","doi":"10.4103/cdr.cdr_37_22","DOIUrl":"https://doi.org/10.4103/cdr.cdr_37_22","url":null,"abstract":"Background: Chronic renal failure patients undergoing dialysis suffer from various side effects and complications where skin ailments are one of them. Skin is the largest and one of the most dynamic organs of the body and can be used as a window since it is easily accessible for observation and reflects changes seen in multiple organs including kidneys. Objective: The objective of this study is to describe various cutaneous manifestations in chronic kidney disease patients undergoing hemodialysis. Materials and Methods: A hospital-based, cross-sectional, observational study was conducted in the department of dermatology, venereology, and leprosy at a tertiary care center from November 2019 to May 2021. The demographic details and clinical manifestations were recorded. Data were recorded as numbers and percentages. For categorical data, the number and percentage were used in the data summaries, and data were analyzed by the Mann‒Whitney U test for the comparison of two data. Results: A total of 94 patients were included in the study. The most common manifestation observed was pruritus (85.1%), followed by xerosis (84%). Other findings seen in the study were mainly nonspecific changes such as pallor (59.57%), diffuse hyperpigmentation (3.2%), and ecchymosis (16%). Nail changes (56.38%) observed were half-and-half nails (22.6%), onycholysis (11%), and Beau's lines (9%). Mucosal changes (36.17%) included depapillated tongue (12.8%) and macroglossia (8.5%). Other findings such as skin infections and keloid were also noted. New finding such as angina bullosa hemorrhagica was seen in one patient. Specific change like Kyrle's disease was seen in 6.4% of the study group and 50% of these patients had concomitant diabetes mellitus. Conclusion: Patients on hemodialysis present with an array of cutaneous manifestations. The most common include pruritus and xerosis. Prompt diagnosis and early treatment help alleviate many of the cutaneous manifestations posed due to hemodialysis.","PeriodicalId":34880,"journal":{"name":"Clinical Dermatology Review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44131380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of clinical efficacy and trichoscopic changes in alopecia areata of the scalp following treatment with intralesional triamcinolone acetonide and autologous platelet-rich plasma 病灶内曲安奈德与自体富血小板血浆治疗斑秃的临床疗效和毛发检查变化的比较
Pub Date : 2023-07-01 DOI: 10.4103/cdr.cdr_14_22
Warood Albadri, A. Inamadar
Background: Alopecia areata (AA) is an autoimmune disease affecting the scalp and body, resulting in hair loss. The fundamental goal of management is to keep the pathology under control. Intralesional corticosteroids suppress T-cell-mediated attacks on hair follicles. Platelet-rich plasma (PRP) contains growth factors that stimulate hair follicle stem cells and have anti-inflammatory properties with fewer side effects. Trichoscopy shows exclamation hair and black dots in the acute stage, yellow dots in long-standing cases, and short vellus hair in regrowing patches. Objective: The aim of this study was to evaluate and compare the efficacy of intralesional triamcinolone acetonide with autologous PRP in the treatment of two different scalp AA patches in the same individual. Materials and Methods: This was a hospital-based prospective follow-up study. Patients with two different patches of alopecia were selected. One was treated with intralesional triamcinolone acetonide (10 mg/ml) and the other with PRP given at 3-week intervals for four treatment sessions. Comparison of results was based on MacDonald Hull and Norris grading system and trichoscopy. Results: Out of 32 patients, 8 (25%) in triamcinolone-treated patches and 3 (9.4%) in PRP-treated patches showed complete hair regrowth at 12 weeks. Furthermore, a faster response was seen with triamcinolone. On trichoscopy, both patches showed an increase in short vellus and terminal hair and a reduction in yellow dots and exclamation hair. No changes in black dots were seen. Conclusion: Intralesional triamcinolone acetonide is more effective than PRP in the treatment of AA of the scalp and is safe. Trichoscopic findings indicate response to treatment and reduction of disease activity.
背景:斑秃(AA)是一种自身免疫性疾病,影响头皮和身体,导致脱发。管理的根本目标是控制病理。病灶内皮质类固醇抑制T细胞介导的对毛囊的攻击。富含血小板的血浆(PRP)含有刺激毛囊干细胞的生长因子,具有抗炎特性,副作用较少。毛发镜检查显示急性期有感叹毛和黑点,长期病例有黄点,再生斑块有短绒毛。目的:本研究的目的是评估和比较病变内曲安奈德和自体PRP治疗同一个体两种不同头皮AA贴片的疗效。材料和方法:这是一项基于医院的前瞻性随访研究。选择了两种不同类型脱发的患者。一个用病灶内曲安奈德(10 mg/ml)治疗,另一个用PRP治疗,间隔3周,共4个疗程。结果的比较基于MacDonald-Hull和Norris分级系统以及毛发检查。结果:在32名患者中,8名(25%)接受曲安奈德治疗的贴片和3名(9.4%)接受PRP治疗的贴片在12周时显示毛发完全再生。此外,曲安奈德的反应更快。在毛发镜检查中,这两种贴片都显示出短毛和顶毛的增加,黄点和感叹毛的减少。黑点没有变化。结论:曲安奈德对头皮AA的治疗效果优于PRP,且安全。毛镜检查结果表明对治疗有反应,疾病活动减少。
{"title":"Comparison of clinical efficacy and trichoscopic changes in alopecia areata of the scalp following treatment with intralesional triamcinolone acetonide and autologous platelet-rich plasma","authors":"Warood Albadri, A. Inamadar","doi":"10.4103/cdr.cdr_14_22","DOIUrl":"https://doi.org/10.4103/cdr.cdr_14_22","url":null,"abstract":"Background: Alopecia areata (AA) is an autoimmune disease affecting the scalp and body, resulting in hair loss. The fundamental goal of management is to keep the pathology under control. Intralesional corticosteroids suppress T-cell-mediated attacks on hair follicles. Platelet-rich plasma (PRP) contains growth factors that stimulate hair follicle stem cells and have anti-inflammatory properties with fewer side effects. Trichoscopy shows exclamation hair and black dots in the acute stage, yellow dots in long-standing cases, and short vellus hair in regrowing patches. Objective: The aim of this study was to evaluate and compare the efficacy of intralesional triamcinolone acetonide with autologous PRP in the treatment of two different scalp AA patches in the same individual. Materials and Methods: This was a hospital-based prospective follow-up study. Patients with two different patches of alopecia were selected. One was treated with intralesional triamcinolone acetonide (10 mg/ml) and the other with PRP given at 3-week intervals for four treatment sessions. Comparison of results was based on MacDonald Hull and Norris grading system and trichoscopy. Results: Out of 32 patients, 8 (25%) in triamcinolone-treated patches and 3 (9.4%) in PRP-treated patches showed complete hair regrowth at 12 weeks. Furthermore, a faster response was seen with triamcinolone. On trichoscopy, both patches showed an increase in short vellus and terminal hair and a reduction in yellow dots and exclamation hair. No changes in black dots were seen. Conclusion: Intralesional triamcinolone acetonide is more effective than PRP in the treatment of AA of the scalp and is safe. Trichoscopic findings indicate response to treatment and reduction of disease activity.","PeriodicalId":34880,"journal":{"name":"Clinical Dermatology Review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49561335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urticaria with immunoglobulin G4-related disease: An association or coincidence? 荨麻疹与免疫球蛋白g4相关疾病:是关联还是巧合?
Pub Date : 2023-04-01 DOI: 10.4103/cdr.cdr_90_21
Nemmar Chandra shekarabhatta Sahana, Shilpa Kanathur, A. Shanmukhappa, T. Revathi
Immunoglobulin (Ig) G4-related disease is a recently described fibro-inflammatory disease with diverse clinical manifestations but consistent and characteristic histopathological features across multiple organ systems and skin, leading to tissue sclerosis and ultimately organ failure if not treated adequately. Here, we report a case of 56-year-old male patient presenting with urticarial lesions and generalized itching for 4 months. Routine investigations showed elevated 24-h urine protein, absolute eosinophil count, serum IgE, reversed albumin: globulin ratio, and “M” spike on serum electrophoresis. Renal biopsy showed storiform fibrosis, diffuse dense inflammatory cells (plasma cells and eosinophils), and IgG4-positive cells on immunohistochemistry which was histologically highly suggestive of IgG4-related chronic tubulointerstitial nephritis. Quick response was seen with oral corticosteroids.
免疫球蛋白(Ig) g4相关疾病是最近发现的一种纤维炎症性疾病,具有多种临床表现,但在多器官系统和皮肤上具有一致和特征性的组织病理学特征,如果治疗不当,可导致组织硬化并最终导致器官衰竭。在此,我们报告一位56岁男性病患,表现为荨麻疹病变及全身瘙痒4个月。常规检查显示24小时尿蛋白升高,嗜酸性粒细胞绝对计数,血清IgE,白蛋白:球蛋白比逆转,血清电泳显示“M”尖峰。肾活检示层状纤维化,弥漫性致密炎性细胞(浆细胞和嗜酸性粒细胞),免疫组化显示igg4阳性细胞,组织学高度提示igg4相关性慢性肾小管间质性肾炎。口服皮质类固醇反应迅速。
{"title":"Urticaria with immunoglobulin G4-related disease: An association or coincidence?","authors":"Nemmar Chandra shekarabhatta Sahana, Shilpa Kanathur, A. Shanmukhappa, T. Revathi","doi":"10.4103/cdr.cdr_90_21","DOIUrl":"https://doi.org/10.4103/cdr.cdr_90_21","url":null,"abstract":"Immunoglobulin (Ig) G4-related disease is a recently described fibro-inflammatory disease with diverse clinical manifestations but consistent and characteristic histopathological features across multiple organ systems and skin, leading to tissue sclerosis and ultimately organ failure if not treated adequately. Here, we report a case of 56-year-old male patient presenting with urticarial lesions and generalized itching for 4 months. Routine investigations showed elevated 24-h urine protein, absolute eosinophil count, serum IgE, reversed albumin: globulin ratio, and “M” spike on serum electrophoresis. Renal biopsy showed storiform fibrosis, diffuse dense inflammatory cells (plasma cells and eosinophils), and IgG4-positive cells on immunohistochemistry which was histologically highly suggestive of IgG4-related chronic tubulointerstitial nephritis. Quick response was seen with oral corticosteroids.","PeriodicalId":34880,"journal":{"name":"Clinical Dermatology Review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41594237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pomelo juice–Drug interactions: A word of caution 柚子汁-药物相互作用:警告
Pub Date : 2023-04-01 DOI: 10.4103/cdr.cdr_62_21
Greeshma K. Shetty, P. Girish, K. Rao, A. Menon
The main of this article is to study the interactions of certain commonly used drugs with pomelo juice which is commonly consumed as easily available fruit or fruit juice in certain parts of India. Relevant literature was identified by searching PubMed and other articles on the web. Various search words which were used are “Grapefruit,” “pomelo,” “drug interactions,” and “juice-drug interactions.” Inclusion criteria included grapefruit juice–drug interaction studies and pomelo juice–drug interactions. Exclusion criteria were articles actually irrelevant to the juice–drug interaction topics. After reviewing the summary of each article, few articles were directly excluded because of actually irrelevant topics. Finally, eight articles were selected as reference articles and certain data were obtained and our opinion about the same is mentioned in the present article. The full text of each included article was critically reviewed, and valuable information was summarized by data interpretation. Pomelo “(Citrus maxima/Citrus grandis)” is the largest citrus fruit from the family Rutaceae and the principal ancestor of the grapefruit. It is a natural, nonhybrid citrus fruit native to Southeast Asia. Pomelo is commonly consumed and used for festive occasions throughout Southeast Asia. It has also been found to have drug interactions similar to grapefruit. The fruit is large, 15–25 cm in diameter, and weighing 1–2 kg. It has a thicker rind than the grapefruit and is divided into 11–18 segments. Pomelo is closely related to grapefruit and extensively studied and contains furanocoumarins which have been identified as inhibitors of cytochrome P450 3A4 in grapefruit juice in vitro. The fruit was first described in 1750 by Griffith Hughes, and in 1789, Patrick Browne referred to it as “forbidden fruit” or “smaller shaddock.” Its taste also varies from sour or bitter to sweet. The fruit is nearly round or slightly pear shaped in clusters similar to grapes, 10–15 cm wide with smooth, finely dotted peel, up to 1 cm thick. The pulp is yellow or pink to red, which has 11–14 segments with thin membrane. The fruit is very juicy. The fruit presents with pointed seeds about 1.25 cm in length. In Karnataka, a type of pomelo named Devanahalli pomelo (Gi registered) is exclusively grown in the region around Devanahalli taluk, Bangalore, as an exotic crop variety. It is locally known as chakkota. Besides, pomelo has many names such as batabi lebu or jambura in Bengali and chakotra in Hindi-speaking states. In the present pandemic outbreak, in-home consumption of packaged fruit juices has increased among people in the cities, whereas in-home consumption of easily grown and easily available fruits such as pomelo, grapes, apples, and their juices has increased among people in the villages. Hence, caution is required while consuming pomelo juice (similar to grapefruit juice) with certain drugs.
本文的主要目的是研究某些常用药物与柚子汁的相互作用,柚子汁在印度某些地区通常被视为容易获得的水果或果汁。通过搜索PubMed和网络上的其他文章来确定相关文献。使用的各种搜索词是“葡萄柚”、“柚子”、“药物相互作用”和“果汁-药物相互作用”。纳入标准包括葡萄柚汁与药物相互作用研究和柚子汁与药物相互作用研究。排除标准是与果汁-药物相互作用主题无关的文章。在审查了每篇文章的摘要后,很少有文章因为实际上不相关的主题而被直接排除。最后选取了8篇文章作为参考文献,获得了一定的数据,并在本文中提出了我们的观点。每篇纳入的文章的全文都经过严格审查,并通过数据解释总结出有价值的信息。柚子(Citrus maxima/Citrus grandis)是芦桃科中最大的柑橘类水果,也是葡萄柚的主要祖先。它是一种天然的非杂交柑橘类水果,原产于东南亚。在整个东南亚,柚子通常被用于节日场合。人们还发现它与葡萄柚有类似的药物相互作用。果实大,直径15-25厘米,重1-2公斤。它的外皮比葡萄柚厚,分为11-18个部分。柚子与葡萄柚有着密切的关系,被广泛研究,它含有呋喃香豆素,在体外被鉴定为葡萄柚汁中细胞色素P450 3A4的抑制剂。1750年,格里菲斯·休斯首次描述了这种水果,1789年,帕特里克·布朗将其称为“禁果”或“小柚子”。它的味道也从酸、苦到甜。果实近圆形或略呈梨形,呈串状,类似葡萄,10-15厘米宽,果皮光滑,细点,厚达1厘米。果肉黄色或粉红色至红色,有11-14节,膜薄。这水果多汁。果实呈尖状,种子长约1.25厘米。在卡纳塔克邦,一种名为Devanahalli柚子(Gi注册)的柚子专门生长在班加罗尔Devanahalli taluk周围地区,作为一种外来作物品种。它在当地被称为chakkota。此外,柚子有许多名字,如孟加拉语的batabi lebu或jambura,以及印度语国家的chakotra。在目前的大流行爆发中,城市居民对包装果汁的家庭消费有所增加,而农村居民对容易种植和容易获得的水果(如柚子、葡萄、苹果及其果汁)的家庭消费有所增加。因此,在服用某些药物的柚子汁(类似于葡萄柚汁)时需要谨慎。
{"title":"Pomelo juice–Drug interactions: A word of caution","authors":"Greeshma K. Shetty, P. Girish, K. Rao, A. Menon","doi":"10.4103/cdr.cdr_62_21","DOIUrl":"https://doi.org/10.4103/cdr.cdr_62_21","url":null,"abstract":"The main of this article is to study the interactions of certain commonly used drugs with pomelo juice which is commonly consumed as easily available fruit or fruit juice in certain parts of India. Relevant literature was identified by searching PubMed and other articles on the web. Various search words which were used are “Grapefruit,” “pomelo,” “drug interactions,” and “juice-drug interactions.” Inclusion criteria included grapefruit juice–drug interaction studies and pomelo juice–drug interactions. Exclusion criteria were articles actually irrelevant to the juice–drug interaction topics. After reviewing the summary of each article, few articles were directly excluded because of actually irrelevant topics. Finally, eight articles were selected as reference articles and certain data were obtained and our opinion about the same is mentioned in the present article. The full text of each included article was critically reviewed, and valuable information was summarized by data interpretation. Pomelo “(Citrus maxima/Citrus grandis)” is the largest citrus fruit from the family Rutaceae and the principal ancestor of the grapefruit. It is a natural, nonhybrid citrus fruit native to Southeast Asia. Pomelo is commonly consumed and used for festive occasions throughout Southeast Asia. It has also been found to have drug interactions similar to grapefruit. The fruit is large, 15–25 cm in diameter, and weighing 1–2 kg. It has a thicker rind than the grapefruit and is divided into 11–18 segments. Pomelo is closely related to grapefruit and extensively studied and contains furanocoumarins which have been identified as inhibitors of cytochrome P450 3A4 in grapefruit juice in vitro. The fruit was first described in 1750 by Griffith Hughes, and in 1789, Patrick Browne referred to it as “forbidden fruit” or “smaller shaddock.” Its taste also varies from sour or bitter to sweet. The fruit is nearly round or slightly pear shaped in clusters similar to grapes, 10–15 cm wide with smooth, finely dotted peel, up to 1 cm thick. The pulp is yellow or pink to red, which has 11–14 segments with thin membrane. The fruit is very juicy. The fruit presents with pointed seeds about 1.25 cm in length. In Karnataka, a type of pomelo named Devanahalli pomelo (Gi registered) is exclusively grown in the region around Devanahalli taluk, Bangalore, as an exotic crop variety. It is locally known as chakkota. Besides, pomelo has many names such as batabi lebu or jambura in Bengali and chakotra in Hindi-speaking states. In the present pandemic outbreak, in-home consumption of packaged fruit juices has increased among people in the cities, whereas in-home consumption of easily grown and easily available fruits such as pomelo, grapes, apples, and their juices has increased among people in the villages. Hence, caution is required while consuming pomelo juice (similar to grapefruit juice) with certain drugs.","PeriodicalId":34880,"journal":{"name":"Clinical Dermatology Review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43908819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dermatoscopy of the pruritic variant of trichostasis spinulosa: A noninvasive diagnostic method 瘙痒型棘毛滴虫的皮肤镜检查:一种无创诊断方法
Pub Date : 2023-04-01 DOI: 10.4103/cdr.cdr_107_21
Mithin Balasundaram, Logamoorthy Ramamoorthy
Trichostasis spinulosa is a hair follicular disorder hyperkeratotic dilated hair follicles with retention of multiple vellus hairs. It is a common disorder often unrecognized by patients. Dermatoscopy helps in diagnosis and deciding the treatment of this disorder avoiding unnecessary skin biopsy. Here, we report a case of a pruritic variant of trichostasis spinulosa with characteristic signs of hair retention in dermatoscopy.
毛发停滞性棘皮病是一种毛囊疾病,角化过度,毛囊扩张,多发绒毛滞留。这是一种常见的疾病,患者往往无法识别。皮肤镜检查有助于诊断和决定这种疾病的治疗方法,避免不必要的皮肤活检。在这里,我们报告了一例在皮肤镜检查中表现出毛发滞留特征性体征的毛发滞留性棘皮病的瘙痒变体。
{"title":"Dermatoscopy of the pruritic variant of trichostasis spinulosa: A noninvasive diagnostic method","authors":"Mithin Balasundaram, Logamoorthy Ramamoorthy","doi":"10.4103/cdr.cdr_107_21","DOIUrl":"https://doi.org/10.4103/cdr.cdr_107_21","url":null,"abstract":"Trichostasis spinulosa is a hair follicular disorder hyperkeratotic dilated hair follicles with retention of multiple vellus hairs. It is a common disorder often unrecognized by patients. Dermatoscopy helps in diagnosis and deciding the treatment of this disorder avoiding unnecessary skin biopsy. Here, we report a case of a pruritic variant of trichostasis spinulosa with characteristic signs of hair retention in dermatoscopy.","PeriodicalId":34880,"journal":{"name":"Clinical Dermatology Review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46131919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Clinical Dermatology Review
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1