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Missing Part of Vitalism: Information. 活力论缺失的部分:信息。
Q3 Medicine Pub Date : 2022-09-01
Mesut Tez

No Abstract Available.

无摘要可用。
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引用次数: 0
Breathing Exercises, Cold-Water Immersion, and Meditation: Mind-Body Practices Lead to Reduced Stress and Enhanced Well-Being. 呼吸练习,冷水浸泡和冥想:身心练习可以减少压力,增强幸福感。
Q3 Medicine Pub Date : 2022-06-01
Troy Faid, William Van Gordon, Elaina C Taylor

Stress is a key contributor to several major life-threatening illnesses including depression and cardiovascular disease. Behavioral strategies that enable individuals to regulate stress responses can lead to improved health and well-being. Such practices may also help reduce required clinical interventions, ease pressure on the National Health Service (NHS), and reduce the need for medical and psychological treatments. This study explores the effects of a novel mind-body therapy for stress reduction and enhanced well-being. A single-group longitudinal intervention design was applied in a study comprising 29 healthy volunteers. The 10-day program was delivered online and consisted of deep-breathing exercises, cold-water exposure, and mindfulness meditation. Participant measures of perceived stress, depression symptoms, and mental well-being were taken at baseline and after completing the 10-day program. A MANOVA analysis revealed significant pre-post intervention differences for all psychometric measures, suggesting the intervention elicited improvements in symptoms of stress, well-being, and depression. This study provides preliminary evidence supporting the efficacy of an innovative mind-body therapy that may be learned and used by individuals to help modulate stress responses, improve mood levels, and enhance well-being. Future research could utilize multi-modal controlled study designs to understand the psychophysiological mechanisms associated with the benefits this practice may generate.

压力是导致包括抑郁症和心血管疾病在内的几种重大威胁生命的疾病的关键因素。使个人能够调节压力反应的行为策略可以改善健康和福祉。这种做法还可能有助于减少所需的临床干预,减轻对国民保健服务(NHS)的压力,并减少对医疗和心理治疗的需求。本研究探讨了一种新的身心疗法对减轻压力和提高幸福感的影响。本研究采用单组纵向干预设计,包括29名健康志愿者。这个为期10天的项目在网上进行,包括深呼吸练习、冷水浸泡和正念冥想。在基线和完成10天的项目后,对参与者的感知压力、抑郁症状和心理健康状况进行测量。方差分析揭示了所有心理测量指标在干预前和干预后的显著差异,表明干预引起了压力、幸福感和抑郁症状的改善。这项研究提供了初步证据,支持一种创新的身心疗法的有效性,这种疗法可以被个人学习和使用,以帮助调节压力反应,改善情绪水平,增强幸福感。未来的研究可以利用多模态对照研究设计来了解与这种做法可能产生的益处相关的心理生理机制。
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引用次数: 0
Qigong in Perceptual Auditory Attention: Tool to Improve Sound Integration in Autism Spectrum Disorders. 知觉听觉注意中的气功:改善自闭症谱系障碍患者声音整合的工具。
Q3 Medicine Pub Date : 2022-06-01
Lara Teixeira Lopes, Luis Carlos Matos, Mario Gonçalves, Bruno Ramos, Maria Joao Santos, Jorge Machado, Henry Johannes Greten

Context: Qigong, a mind-body practice in traditional Chinese medicine (TCM), can improve cognitive functions, emotional balance, attention, multitask management, stress-coping, and well-being. One limitation of Qigong research is a lack of adequate controls.

Objective: The current study intended to evaluate whether a single 5-min practice of a White Ball (WB) Qigong exercise could improve the perceptual auditory attention, divided and focused, in adults and whether obtaining potential effects would require a minimum level of training.

Design: The research team designed a prospective, randomized, placebo-controlled, and single-blinded study.

Setting: The study took place at the Institute of Biomedical Sciences (ICBAS) at the University of Porto in Porto, Portugal.

Participants: Participants were 55 students at the University of Porto, 30 of whom were students attending the second year of medical school at ICBAS with no experience in Qigong and 25 of whom were students in the specialization and Master's programs in TCM with experience in Qigong.

Intervention: The research team randomly distributed the 30 participants without experience into two groups, a negative control group (n = 15), who watched a wildlife video for 5 min in an orthostatic position, and a positive control group , the verum Qigong group (n = 15), who participated in 5 min of Qigong practice. The Qigong-practitioner group (n = 25), the intervention group, participated in the same 5-min Qigong, doing it with expertise.

Outcome measures: The study measured reaction time (RT) under two experimental conditions, one an auditory RT task and the second an auditory RT task with visual distraction. The procedure was constant for all the studied groups.

Results: Postintervention, the reaction time (RT) in the negative control and the verum Qigong groups hadn't changed significantly (P > .05), while that of the Qigong-practitioner group had decreased significantly, with shorter RTs under the two experimental conditions, with P = .006 for the auditory RT and P = .003 for the auditory + visual distraction. Qigong may induce a conditioning effect that comes with regular practice.

Conclusions: The WB Qigong had a positive effect on the AA mechanism, with a significant reduction in RT. The results support the importance of practice to achieve positive effects. People with neurodevelopmental disorders, such as autism and ADHD, struggle every day for sensory integration of AA mechanisms. Qigong can be taught and easily learned from the age of 2 years until senior ages, and it's a safe and very low-cost intervention that deserves to be researched further in clinical trials. These potential benefits of Qigong should be confirmed by future studies.

背景:气功是中医的一种身心练习,可以改善认知功能、情绪平衡、注意力、多任务管理、压力应对和健康。气功研究的一个局限是缺乏足够的控制。目的:本研究旨在评估单次5分钟的白球气功练习是否可以改善成人的感知听觉注意力、分裂和集中,以及是否需要最低水平的训练才能获得潜在的效果。设计:研究小组设计了一项前瞻性、随机、安慰剂对照、单盲研究。环境:该研究在葡萄牙波尔图波尔图大学生物医学科学研究所(ICBAS)进行。参与者:波尔图大学的55名学生,其中30名是ICBAS医学院二年级的学生,没有气功经验,25名是中医专业和硕士课程的学生,有气功经验。干预:研究小组将30名没有经验的参与者随机分为两组,阴性对照组(n = 15),以直立姿势观看野生动物视频5分钟,阳性对照组(n = 15), verum气功组,参加气功练习5分钟。气功练习者组(n = 25),即干预组,参加同样的5分钟气功练习,并进行专业练习。结果测量:本研究测量了两种实验条件下的反应时间(RT),一种是听觉RT任务,另一种是视觉分心的听觉RT任务。所有研究组的程序都是不变的。结果:干预后,阴性对照组和verum气功组的反应时间(RT)无显著变化(P > 0.05),而气功组的反应时间(RT)显著降低,两种实验条件下的RT均缩短,听觉RT P = 0.006,听觉+视觉分心P = 0.003。经常练习气功可能会产生一种调节效果。结论:WB气功对AA机制有积极作用,显著降低rt,支持练习对达到积极效果的重要性。患有神经发育障碍的人,如自闭症和多动症,每天都在为AA机制的感觉整合而挣扎。气功是一种安全、低成本的干预方法,值得在临床试验中进一步研究。从2岁开始,直到老年,气功都可以很容易地教授和学习。气功的这些潜在益处应该在未来的研究中得到证实。
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引用次数: 0
Effect of a Structured Naturopathy and Yoga Intervention on Pain, Depression, and Quality of Sleep in a Postmenopausal Breast Cancer Patient. 结构化自然疗法和瑜伽干预对绝经后乳腺癌患者疼痛、抑郁和睡眠质量的影响
Q3 Medicine Pub Date : 2022-06-01
Y Deepa, Seithoon Nisha, A Mooventhan, N Manavalan, S Edmin Christa

A 54-year-old postmenopausal woman was diagnosed with adenoid cystic carcinoma (ACCA) of the right breast. She had complaints of pain in the upper quadrant of the right breast, stress, disturbed sleep, and depression. Her self-reported pain intensity using the visual analog scale (VAS) was 8 and her perceived stress scale value was 19. Her depression score on the Patient Health Questionnaire-9 (PHQ-9) was 12. Her quality of sleep, evaluated using the Pittsburgh Sleep Quality Index (PSQI), was 18. She was given integrated naturopathy and yoga therapy for 43 days. She showed a reduction in pain, stress, and depression scores. Her quality of sleep also improved after the integrated naturopathy and yoga therapy. Our structured integrated naturopathy and yoga therapy improved pain, stress, depression, and sleep quality in a postmenopausal breast cancer patient and may be used as adjuvant therapy for patients with breast cancer.

一位54岁的绝经后妇女被诊断为右乳房腺样囊性癌(ACCA)。她主诉右乳上腹疼痛,压力大,睡眠不安,抑郁。采用视觉模拟量表(VAS)自述疼痛强度为8,感知压力量表值为19。患者健康问卷-9 (PHQ-9)抑郁得分为12分。使用匹兹堡睡眠质量指数(PSQI)评估她的睡眠质量为18。她接受了43天的综合自然疗法和瑜伽疗法。她的疼痛、压力和抑郁得分都有所下降。经过自然疗法和瑜伽的综合治疗后,她的睡眠质量也有所改善。我们的结构化综合自然疗法和瑜伽疗法改善了绝经后乳腺癌患者的疼痛、压力、抑郁和睡眠质量,并可作为乳腺癌患者的辅助治疗。
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引用次数: 0
Effects of Yoga on Cognitive Functions Among Adolescents. 瑜伽对青少年认知功能的影响。
Q3 Medicine Pub Date : 2022-02-01
Lavya Shetty, Gajjela Govardhan Reddy, Priyanka Krishnan, Indu Toby, Shwetha Ts, Annapoorna K

Context: Yoga is beneficial in enhancing mental health and consequently cognitive growth. Some studies have show that yoga practice can improve cognitive functioning in children.

Objective: The study intended to evaluate the effectiveness of a school-based yoga intervention on the cognitive abilities-attention and memory-of adolescents.

Design: The research team conducted a one-group, pretest-posttest study.

Setting: The study occurred at a rural residential school in Udupi, Karnataka, and South India.

Participants: Participants were a convenience sample of 36 adolescents, with a mean age of 12.19 ± 0.4 years, in the seventh grade at the school.

Intervention: A senior yoga expert prepared a structured, yoga-intervention module, which was implemented, with each session lasting one hour and occurring five days a week for 12 weeks.

Outcome measures: The Digit Span Forward (DSF) and Digit Span Backward (DSB) tests and Letter-Number Sequencing (LNS) test were used by a trained research examiner to evaluate cognition.

Results: Comparing the mean DSB, total digit span score, and LNS at baseline and postintervention showed significantly higher posttest scores than pretest ones, with P = .005, P = .005, and P = .001, respectively.

Conclusions: Yoga training improves cognitive functions and is a simple, low-cost, and effective adjuvant modality.

背景:瑜伽有利于增强心理健康,从而促进认知能力的增长。一些研究表明,瑜伽练习可以改善儿童的认知功能。目的:本研究旨在评估以学校为基础的瑜伽干预对青少年认知能力-注意力和记忆的有效性。设计:研究小组进行了一组前测后测研究。环境:研究发生在印度南部卡纳塔克邦Udupi的一所农村寄宿学校。参与者:选取该学校七年级36名青少年作为方便样本,平均年龄12.19±0.4岁。干预:一位资深瑜伽专家准备了一个结构化的瑜伽干预模块,并实施了该模块,每个课程持续一小时,每周进行五天,持续12周。结果测量:由训练有素的研究考官使用数字跨距前向(DSF)和数字跨距后向(DSB)测试和字母数字排序(LNS)测试来评估认知。结果:比较基线和干预后的平均DSB、总手指跨距评分和LNS,测试后得分显著高于测试前得分,P = 0.005, P = 0.005, P = 0.001。结论:瑜伽训练可提高认知功能,是一种简单、低成本、有效的辅助方式。
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引用次数: 0
Preliminary Research into the Effects of Higher Brain Living on Well-being. 高脑生活对幸福感影响的初步研究。
Q3 Medicine Pub Date : 2022-02-01
David Seagull

Context: Higher Brain Living (HBL) is a light-touch therapy, which practitioners claim can increase well-being. Although studies have suggested that its component elements-light touch, focused breathing, and positive self-talk-can increase well-being for specific populations in specific contexts, no empirical research has occurred on HBL's efficacy.

Objective: The study intended to measure the effects of HBL therapy on the well-being of individuals who have received it.

Design: The research team designed a quasi-experimental controlled trial that used a survey to gather self-reported data related to well-being.

Setting: The study took place in individual HBL practitioners' locations throughout the USA.

Participants: Participants were adults who had attended an introductory presentation about HBL.

Intervention: Participants were assigned to one of three groups: (1) the intervention group, who had responded to the baseline and postintervention surveys and had participated in HBL sessions (n = 14); (2) the control group, who had responded to the baseline and postintervention surveys and had not participated in HBL sessions (n = 9); and (3) the noncompleter group who had responded to the baseline surveys and had not completed the postintervention survey (n = 54).

Outcome measures: Well-being was assessed using five measures that evaluated constructs associated with well-being: (1) happiness using the Subjective Happiness Scale (SHS), (2) anxiety using the Anxiety Index (AI), (3) depression using Depression Index (DI) (4) mastery using the Pearlin Mastery Scale (PM), and (5) flourishing using the Flourishing Scale (FS).

Results: The study included baseline data from 77 respondents; 23 participants completed the surveys at baseline and postintervention, 14 in the intervention group and 9 in the control group. A statistically significant, greater improvement occurred for the intervention group in the measures for flourishing, mastery, and happiness compared to the control group.

Conclusions: The current study provides a foundation of empirical evidence suggesting the effectiveness of HBL as a potential treatment for improving well-being, upon which further investigation can be based.

背景:高级大脑生活(HBL)是一种轻触疗法,从业者声称可以增加幸福感。虽然有研究表明,它的组成要素——轻触、专注呼吸和积极的自我对话——可以在特定环境下增加特定人群的幸福感,但还没有关于HBL功效的实证研究。目的:本研究旨在测量HBL治疗对接受HBL治疗的个体幸福感的影响。设计:研究小组设计了一项准实验控制试验,通过调查收集与幸福感相关的自我报告数据。背景:本研究在美国各地的个别HBL从业人员中进行。参与者:参与者为参加过HBL介绍性演讲的成年人。干预:参与者被分配到三组中的一组:(1)干预组,他们对基线和干预后调查有反应,并参加了HBL会议(n = 14);(2)对照组,对基线和干预后调查有反应,未参加HBL疗程(n = 9);(3)已完成基线调查但未完成干预后调查的未完成者组(n = 54)。结果测量:幸福感的评估使用了与幸福感相关的五种测量方法:(1)使用主观幸福感量表(SHS)来评估幸福感,(2)使用焦虑指数(AI)来评估焦虑,(3)使用抑郁指数(DI)来评估抑郁,(4)使用Pearlin掌握量表(PM)来评估掌握,(5)使用繁荣量表(FS)来评估繁荣。结果:该研究包括77名受访者的基线数据;23名参与者在基线和干预后完成了调查,干预组14名,对照组9名。与对照组相比,干预组在繁荣、精通和幸福方面有了显著的改善。结论:目前的研究提供了经验证据的基础,表明HBL作为改善幸福感的潜在治疗方法的有效性,在此基础上可以进行进一步的研究。
{"title":"Preliminary Research into the Effects of Higher Brain Living on Well-being.","authors":"David Seagull","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Context: </strong>Higher Brain Living (HBL) is a light-touch therapy, which practitioners claim can increase well-being. Although studies have suggested that its component elements-light touch, focused breathing, and positive self-talk-can increase well-being for specific populations in specific contexts, no empirical research has occurred on HBL's efficacy.</p><p><strong>Objective: </strong>The study intended to measure the effects of HBL therapy on the well-being of individuals who have received it.</p><p><strong>Design: </strong>The research team designed a quasi-experimental controlled trial that used a survey to gather self-reported data related to well-being.</p><p><strong>Setting: </strong>The study took place in individual HBL practitioners' locations throughout the USA.</p><p><strong>Participants: </strong>Participants were adults who had attended an introductory presentation about HBL.</p><p><strong>Intervention: </strong>Participants were assigned to one of three groups: (1) the intervention group, who had responded to the baseline and postintervention surveys and had participated in HBL sessions (n = 14); (2) the control group, who had responded to the baseline and postintervention surveys and had not participated in HBL sessions (n = 9); and (3) the noncompleter group who had responded to the baseline surveys and had not completed the postintervention survey (n = 54).</p><p><strong>Outcome measures: </strong>Well-being was assessed using five measures that evaluated constructs associated with well-being: (1) happiness using the Subjective Happiness Scale (SHS), (2) anxiety using the Anxiety Index (AI), (3) depression using Depression Index (DI) (4) mastery using the Pearlin Mastery Scale (PM), and (5) flourishing using the Flourishing Scale (FS).</p><p><strong>Results: </strong>The study included baseline data from 77 respondents; 23 participants completed the surveys at baseline and postintervention, 14 in the intervention group and 9 in the control group. A statistically significant, greater improvement occurred for the intervention group in the measures for flourishing, mastery, and happiness compared to the control group.</p><p><strong>Conclusions: </strong>The current study provides a foundation of empirical evidence suggesting the effectiveness of HBL as a potential treatment for improving well-being, upon which further investigation can be based.</p>","PeriodicalId":34899,"journal":{"name":"Advances in Mind-Body Medicine","volume":"36 2","pages":"8-13"},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40194776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development, Content Validation, and Feasibility of Yoga Module for Smartphone Addiction. 智能手机成瘾瑜伽模块的开发、内容验证和可行性
Q3 Medicine Pub Date : 2022-02-01
Krishna Chaitanya Putchavayala, Sasidharan K Rajesh, Deepeshwar Singh

Context: Mental health practitioners have postulated that smartphone addiction is a disorder characterized by maladaptive and problematic behavior, and treatment modalities are scarce. Yoga has been found to be a viable tool for addiction treatment and other psychiatric conditions, but no specific validated module is currently available for smartphone addiction.

Objective: The study intended: (1) to develop a yoga-based intervention for smartphone addiction, based on the ancient literature of yoga and a modern literature review; (2) to validate the developed module with experts from different schools of yoga; and (3) to test the module's feasibility and efficacy for young adolescents, with the objective of creating biopsychosocial well-being.

Design: The research team first conducted a search of traditional and contemporary literature, with the objective of developing the yoga program. That yoga program was then sent to yoga experts for content validation. A pilot study then tested the feasibility of using the developed module for individuals with internet and smartphone addiction.

Setting: The study took place in Swami Vivekananda Yoga Anusandhana Samsthana (S-VYASA) University, Bengaluru, India.

Participants: For content validity, participants were 15 yoga experts who had >10 years of experience in treating mental health disorders. For feasibility in a pilot study, participants were 22 students from an engineering college in Bengaluru, South India.

Outcome measures: For content validity, the experts' opinions were rated using a content validation ratio (CVR) through Lawshe's formula. For the feasibility study, assessments were performed at baseline and post intervention. Data were collected to evaluate: (1) addiction level using the Smartphone Addiction Scale - Short Version (SAS-SV), (2) impulsiveness using the Barat Impulsive Scale (BIS); (3) sleep problems using the Pittsburgh Sleep Quality Index (PSQI), (4) mindfulness using the Mindful Attention Awareness Scale (MAAS), (4) self-regulation using the Short Self-Regulation Questionnaire (SSRQ); and general health using the General Health Questionnaire (GHQ-12).

Results: In the final version of the module, 26 out of 35 items (74.28%) of the practices in the developed program were retained, together with the modifications suggested by the experts. The content validity index for the whole module, an average of all CVRs, was 0.74. The study found significant reductions in the most symptom scores after participants practiced the yoga module for six weeks.

Conclusions: A yoga module for smartphone addiction was developed, validated, and checked for feasibility. The content validity of the module was found to be good. The module was found to potentially useful for reducing symptoms in individuals with smartphone addiction

背景:心理健康从业者假设智能手机成瘾是一种以适应不良和问题行为为特征的疾病,治疗方式很少。瑜伽已经被发现是一种治疗成瘾和其他精神疾病的可行工具,但目前还没有针对智能手机成瘾的特定验证模块。目的:本研究旨在:(1)在古代瑜伽文献和现代文献综述的基础上,开发一种基于瑜伽的智能手机成瘾干预方法;(2)与不同瑜伽流派的专家对开发的模块进行验证;(3)以创造生物心理社会福祉为目标,检验该模块在青少年群体中的可行性和有效性。设计:研究团队首先对传统和当代文献进行了搜索,目的是开发瑜伽课程。然后,该瑜伽课程被送到瑜伽专家那里进行内容验证。一项试点研究随后测试了将开发的模块用于网络和智能手机成瘾者的可行性。环境:研究在印度班加罗尔的斯瓦米·维韦卡南达瑜伽学院(S-VYASA)进行。参与者:对于内容效度,参与者是15名具有>10年治疗精神健康障碍经验的瑜伽专家。为了可行性,在一项试点研究中,参与者是来自印度南部班加罗尔一所工程学院的22名学生。结果测量:对于内容效度,通过Lawshe公式使用内容验证率(CVR)对专家的意见进行评级。对于可行性研究,在基线和干预后进行评估。收集的数据用于评估:(1)使用智能手机成瘾量表-短版本(SAS-SV)的成瘾水平;(2)使用Barat冲动量表(BIS)的冲动性;(3)采用匹兹堡睡眠质量指数(PSQI)评估睡眠问题;(4)采用正念注意意识量表(MAAS)评估正念;(4)采用短自我调节问卷(SSRQ)评估自我调节;使用一般健康问卷(GHQ-12)进行一般健康调查。结果:在模块最终版本中,保留了开发方案中35条实践中的26条(74.28%),并保留了专家建议的修改。整个模块的内容效度指数,即所有CVRs的平均值为0.74。研究发现,在参与者练习瑜伽模块六周后,大多数症状得分显著降低。结论:针对智能手机成瘾的瑜伽模块被开发、验证并验证了可行性。结果表明,该模块的内容有效性良好。该模块被发现可能有助于减轻智能手机成瘾者的症状。未来的研究应通过随机对照临床试验来检验开发方案的有效性。
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引用次数: 0
"My Body Does Not Fit in Your Medical Textbooks": A Physically Turbulent Life With an Unexpected Recovery From Advanced Parkinson Disease After Prayer. “我的身体不适合你的医学教科书”:一个身体动荡的生活与祈祷后从晚期帕金森病意外恢复。
Q3 Medicine Pub Date : 2021-12-01
Dirk J Kruijthoff, Elena Bendien, Corlien Doodkorte, Cornelis van der Kooi, Gerrit Glas, Tineke A Abma

Aim: The purpose of this article is to enhance our understanding of prayer healing by studying a case which was described as a 'remarkable healing' by a medical assessment team at the Amsterdam University Medical Centre (UMC) in the Netherlands.

Method: This retrospective, case-based study of prayer healing investigated numerous reported healings using both medical files and patient narratives. A medical assessment team evaluated the associated medical files, as well as any experiential data. The instances of healing could be classified as 'remarkable' or 'unexplained.' Experiential data were obtained by qualitative, in-depth interviews. The study was transdisciplinary in nature, involving medical, psychological, theological, and philosophical perspectives. The object was to understand such healings within the broader framework of the science-religion debate.

Results: We present the case of a female patient, born in 1959, with Parkinson disease who experienced instantaneous, nearly complete healing in 2012 after intercessory prayer. At that point the disease was at an advanced stage, rapidly progressive, with major debilitating symptoms. High doses of oral medication were required. Following this healing there was no recurrence of her former symptoms, while the remaining symptoms continued to improve. She regained all of her capacities at work, as well as in daily life. The medical assessment team described her recovery as 'remarkable.' The patient reported that she had always 'lived with God,' and that at a point when she had given up hope, 'life was given back to her.' This recovery did not make her immune to other illnesses and suffering, but it did strengthen her belief that God cares about human beings.

Conclusion: This remarkable healing and its context astonished the patient, her family, and her doctors. The clinical course was extraordinary, contradicting data from imaging studies, as well as the common understanding of this disease. This case also raised questions about medical assumptions. Any attempt to investigate such healings requires the involvement of other disciplines. A transdisciplinary approach that includes experiential knowledge would be helpful. Against the background of the science-religion debate, we feel that the most helpful approach would be one of complementarity and dialogue, rather than stoking controversy.

目的:本文的目的是通过研究一个被荷兰阿姆斯特丹大学医学中心(UMC)的医学评估小组描述为“显着愈合”的案例来提高我们对祈祷愈合的理解。方法:这个回顾性的,基于案例的研究祈祷愈合调查了许多报告的愈合使用医疗档案和病人的叙述。医疗评估小组评估了相关的医疗档案以及任何经验数据。治愈的实例可以分为“显著”和“无法解释”两类。经验数据是通过定性的深度访谈获得的。这项研究本质上是跨学科的,涉及医学、心理学、神学和哲学的观点。其目的是在科学-宗教辩论的更广泛框架内理解这种治疗。结果:我们提出了一名1959年出生的女性帕金森病患者的病例,在代祷后,她在2012年经历了瞬间,几乎完全治愈。那时,这种疾病已进入晚期,病情迅速恶化,出现了严重的衰弱症状。需要大剂量的口服药物。在此治疗后,她以前的症状没有复发,而其余的症状继续改善。她恢复了所有的工作能力和日常生活能力。医疗评估小组称她的恢复情况“非常显著”。这位病人说,她一直“与上帝生活在一起”,在她放弃希望的时候,“生命又回到了她的身边”。这次康复并没有使她对其他疾病和痛苦免疫,但它确实加强了她对上帝关心人类的信念。结论:这种显著的治愈及其背景令病人、她的家人和她的医生感到震惊。临床过程是不寻常的,与影像学研究的数据以及对这种疾病的普遍认识相矛盾。这个案例也引发了对医学假设的质疑。任何研究这种治愈的尝试都需要其他学科的参与。包括经验知识在内的跨学科方法将会有所帮助。在科学与宗教辩论的背景下,我们认为最有帮助的方法是互补和对话,而不是挑起争议。
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引用次数: 0
The Role of Spiritual Care and Healing in Health Management. 精神关怀和治疗在健康管理中的作用。
Q3 Medicine Pub Date : 2021-12-01
Matt Snapp, Lisa Hare

There is substantial evidence that spiritual well-being is an important determinant of overall health, longevity and quality of life, especially in patients with severe illness. While most physicians would agree that spiritual well-being is an important factor in their patients' health, the spiritual needs and well-being of patients are largely ignored and rarely addressed by healthcare providers, representing a significant gap in care. Physicians often cite a lack of training or comfort in assessing and/or addressing patients' spiritual needs, and a lack of research on the safety and efficacy of spiritual interventions as barriers to care. In this review, we discuss the effects of spiritual well-being on health, and the importance of assessing and addressing patients' spiritual needs, highlight the need for methodic, rigorous high-quality studies and improved physician education in identifying and addressing patients' spiritual needs.

有大量证据表明,精神健康是总体健康、寿命和生活质量的重要决定因素,对患有严重疾病的患者来说尤其如此。虽然大多数医生都同意精神健康是患者健康的一个重要因素,但医疗保健提供者在很大程度上忽视了患者的精神需求和福祉,很少解决这些问题,这代表了护理方面的重大差距。医生们通常认为,在评估和/或解决病人的精神需求方面缺乏培训或缺乏舒适性,以及缺乏对精神干预的安全性和有效性的研究,这些都是护理的障碍。在这篇综述中,我们讨论了精神健康对健康的影响,以及评估和解决患者精神需求的重要性,强调了在识别和解决患者精神需求方面需要有条理、严格的高质量研究和改进医生教育。
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引用次数: 0
The Role of Diazepam in Epigenetics: From the Molecular Level to Clinical Implications. 地西泮在表观遗传学中的作用:从分子水平到临床意义。
Q3 Medicine Pub Date : 2021-12-01
Sachchidanand Pathak, Gaurav Gupta, Ritu M Gilhotra

There is growing evidence linking epigenetic mutations to neurologic disorders such as epilepsy. The effect of the medications primarily used to treat neurologic disorders has recently been studied, including research on epilepsy and the epigenetic process. The impact of the widely used medication diazepam on epigenomics, microRNA levels, the ensuing genetic exposure and potential clinical effects was reviewed. The action of diazepam, particularly in altering the synthesis of enzyme 5' adenosine monophosphate activated protein kinase (AMPK) was found to affect many enzymes, which changes or modifies the epigenetics. Epigenetic enzymes such as histone acetyltransferases (HATs), class II histone deacetylases (HDACs) and DNA methyltransferases (DNMTs) are mainly activated by AMPKs, including the phosphorylate substrates, which often lead to their inhibition, although HAT1 activity may be improved. It has been reported that diazepam can reduce histone methyltransferase expression exposure, may increase class III histone deacetylases activity and may decrease the effect of DNA methyltransferases inhibitors. Diazepam has been found to contribute to mutations of the epigenome and genetic expression, and may protect against neurologic disorders, aging, dementia and several brain diseases. It has also been found that microRNA expression can be influenced by diazepam treatment and may have neurologic effects. Although the reported effects of diazepam on epigenetic enzymes of are equally effective in both amplifying and reducing acetylation of histone, histone and DNA methylation and gene expression, the effect of diazepam on the epigenome, genetic expression, and subsequent effects in all healthy diazepam users is unclear.

越来越多的证据表明,表观遗传突变与癫痫等神经系统疾病有关。最近研究了主要用于治疗神经系统疾病的药物的效果,包括对癫痫和表观遗传过程的研究。本文综述了广泛应用的药物安定对表观基因组学、microRNA水平、随后的遗传暴露和潜在临床效应的影响。地西泮的作用,特别是在改变酶5'腺苷单磷酸活化蛋白激酶(AMPK)的合成时,被发现影响许多酶,从而改变或修饰表观遗传学。表观遗传酶如组蛋白乙酰转移酶(HATs)、II类组蛋白去乙酰化酶(hdac)和DNA甲基转移酶(dnmt)主要由ampk激活,包括磷酸化底物,这通常导致它们的抑制,尽管HAT1活性可能会提高。据报道,地西泮可以降低组蛋白甲基转移酶的表达暴露,可能增加III类组蛋白去乙酰化酶的活性,并可能降低DNA甲基转移酶抑制剂的作用。地西泮已被发现有助于表观基因组和遗传表达的突变,并可能防止神经系统疾病、衰老、痴呆和几种脑部疾病。还发现microRNA表达可受地西泮治疗影响,并可能具有神经系统作用。尽管报道的地西泮对表观遗传酶的影响在组蛋白乙酰化、组蛋白和DNA甲基化以及基因表达的扩增和减少方面同样有效,但在所有健康的地西泮使用者中,地西泮对表观基因组、遗传表达的影响以及随后的影响尚不清楚。
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Advances in Mind-Body Medicine
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