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Current understanding of extracellular vesicle homing/tropism. 目前对细胞外囊泡归宿/回归的理解。
Q3 Social Sciences Pub Date : 2022-01-01 Epub Date: 2022-05-12 DOI: 10.15212/zoonoses-2022-0004
Mariola J Edelmann, Peter E Kima

Extracellular vesicles (EVs) are membrane-enclosed packets released from cells that can transfer bioactive molecules from cell to cell without direct contact with the target cells. This transfer of molecules can activate consequential processes in the recipient cells, including cell differentiation and migration that maintain tissue homeostasis or promote tissue pathology. One controversial aspect of the EV's biology that holds therapeutic promise is their capacity to engage defined cells at specific sites. On the one hand, persuasive studies have shown that EVs express surface molecules that ensure their tissue localization and enable cell-specific interactions, as demonstrated using in vitro and in vivo analyses. Therefore, this feature of EV biology is under investigation in translational studies to control malignancies and deliver chemicals and bioactive molecules to combat several diseases. On the other hand, some studies have shown that EVs fail to traffic in hosts in a targeted manner, which questions the potential role of EVs as vehicles for drug delivery and their capacity to serve as cell-free biomodulators. In this review, the biology of EV homing/tropism in mammalian hosts is discussed, and the biological characteristics that may result in their controversial characteristics are brought to the fore.

细胞外囊泡(EVs)是细胞释放的膜封闭包,可在不与目标细胞直接接触的情况下将生物活性分子从细胞转移到细胞。这种分子转移可以激活受体细胞的相应过程,包括细胞分化和迁移,从而维持组织稳态或促进组织病变。EV 生物学中一个有争议但有治疗前景的方面是其在特定部位与特定细胞接触的能力。一方面,令人信服的研究表明,EVs 表达的表面分子可确保其组织定位并实现细胞特异性相互作用,体外和体内分析均证明了这一点。因此,EV 生物学的这一特征正在转化研究中进行调查,以控制恶性肿瘤,并输送化学物质和生物活性分子来防治多种疾病。另一方面,一些研究表明,EVs 无法以有针对性的方式在宿主体内流动,这就对 EVs 作为药物递送载体的潜在作用及其作为无细胞生物调节剂的能力提出了质疑。在这篇综述中,我们讨论了EV在哺乳动物宿主中的归巢/转运生物学,并提出了可能导致其具有争议性的生物学特征。
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引用次数: 0
Eliciting Best Evidence from a Child Witness: A Comparative Study of the United Kingdom and India 从儿童证人那里获得最佳证据:英国和印度的比较研究
Q3 Social Sciences Pub Date : 2019-08-27 DOI: 10.1515/ILS-2019-0003
C. Singh
The successful prosecution of any criminal offence relies on evidence that proves its commission. Although the admissibility of evidence is key at first instance, the weight attached to a piece of evidence i.e. how “reliable” or “persuasive” it is will tilt the scale of justice in one or another direction. The problems with various forms of evidence i.e. that elicited from an eye or ear-witness has been thoroughly explored by academics and lawyers alike. Those same problems are potentially exacerbated where the witness is a child who has not only witnessed a gruesome crime but is required to give evidence in a forum (court) that is accompanied by intimidating surroundings. Whilst witness evidence, regardless of whether it is given by an adult or child, is a factual part of criminal justice, it is salient to note that the entire process has been made more witness-friendly in some commonwealth jurisdictions. This article explores the differences in the rules designed on eliciting best evidence from a child witness in the United Kingdom and India. In so doing, the case law from each jurisdiction is contrasted. There are two aims of the article, the first is to facilitate a conversation where one criminal justice system may learn from another’s experience. The second, a result of the first, is to make suggestions on improving the experience of a child witness in the Indian Criminal Justice Process.
任何刑事犯罪的成功起诉都依赖于证明其犯罪的证据。尽管证据的可采性在一审中是关键,但对一份证据的重视,即它的“可靠性”或“说服力”,将使司法天平朝着一个或另一个方向倾斜。学者和律师都对各种形式的证据问题进行了深入探讨,即从眼睛或耳朵的证人那里获得的证据。如果证人是一名儿童,他不仅目睹了可怕的罪行,而且被要求在充满恐吓的环境中出庭作证,那么同样的问题可能会加剧。尽管证人证据,无论是由成年人还是儿童提供,都是刑事司法的事实组成部分,但值得注意的是,在一些英联邦司法管辖区,整个过程对证人更加友好。本文探讨了英国和印度在从儿童证人那里获取最佳证据的规则方面的差异。在这样做的过程中,对每个司法管辖区的判例法进行了对比。这篇文章有两个目的,第一个目的是促进一种对话,一个刑事司法系统可以从另一个系统的经验中学习。第二个是第一个的结果,是就改善儿童证人在印度刑事司法程序中的经验提出建议。
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引用次数: 0
Tort Policy in a Plural Context: Pathways Towards Objective Liability in UAE Tort Law 多元背景下的侵权政策:阿联酋侵权法中客观责任的路径
Q3 Social Sciences Pub Date : 2019-08-27 DOI: 10.1515/ILS-2019-0001
Iyad Mohammad Jadalhaq
This article approaches tort policy contextually, as an argument around actually available alternatives within a historically-specific legal tradition, like that of the United Arab Emirates (UAE), which combines French civil law influence with roots in Islamic law. The article examines alternative tunings of the requirements of tort liability, in view of cases where a technically sophisticated investigation is required to ascertain what precautions the tortfeasor might have taken to prevent injury. For this purpose, it takes as its point of departure a careful assessment of the availability of the “extraneous cause” exception in UAE law, which allows defendants to avoid liability by demonstrating the occurrence of a causal factor outside their sphere of control. To understand when this exception ought to be available, the paper engages in critical dialogue with French doctrines on tort liability, distinguishing a fault-based “subjective approach” from an “objective approach” (strict liability). These doctrines also speak to Arab jurisdictions that have adopted a civil code (like the UAE), modelled after the French one. The article therefore proceeds to situate the tort regime in the UAE Civil Code with respect to those French doctrines. With respect to these, the UAE Civil Code takes an intermediate position drawn from Islamic law. However, additional provisions, e.g. on liability for nuclear installations or for machinery of which a person is in charge, demonstrate a timid reception of the objective approach. The article proposes a reform of UAE tort liability on the basis of the objective approach, which is robust even in complex cases, where an investigation around causation would risk being inconclusive. Finally, the paper considers the additional possibility of arguing for a voluntary assumption of liability on the part of the tortfeasor, as yet another way of orienting tort liability in the UAE towards an objective approach.
本文将侵权政策置于背景下,作为一种围绕历史特定法律传统中实际可用的替代方案的争论,如阿拉伯联合酋长国(UAE)的法律传统,该传统将法国民法的影响与伊斯兰法的根源相结合。鉴于需要进行技术复杂的调查以确定侵权人可能采取了哪些预防措施来防止损害的情况,该条审查了侵权责任要求的替代调整。为此,它以仔细评估阿联酋法律中“无关原因”例外的可用性为出发点,该例外允许被告通过证明其控制范围之外的因果因素的发生来避免责任。为了理解这一例外情况何时适用,本文与法国关于侵权责任的学说进行了批判性对话,区分了基于过错的“主观方法”和“客观方法”(严格责任)。这些学说也适用于效仿法国民法的阿拉伯司法管辖区(如阿联酋)。因此,本条继续将《阿联酋民法典》中的侵权行为制度与法国的这些学说联系起来。在这些方面,《阿联酋民法典》采取了伊斯兰法的中间立场。然而,关于核设施或由一个人负责的机械的赔偿责任等附加条款表明,对客观方法的接受程度很低。这篇文章提出了在客观方法的基础上对阿联酋侵权责任进行改革,即使在复杂的案件中,这种方法也很稳健,因为围绕因果关系的调查可能会没有结论。最后,本文考虑了主张侵权人自愿承担责任的额外可能性,这是将阿联酋侵权责任定位为客观方法的另一种方式。
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引用次数: 2
Bumped Redundancy and the Range of Reasonable Responses: To what Extent, if any, should Employers Consider Bumping? Life after Mirab v Mentor Graphics Limited UKEAT/0172/17DA 裁员和合理回应的范围:如果有的话,雇主应该在多大程度上考虑裁员?Mirab诉Mentor Graphics Limited案后的生活UKEAT/0172/17DA
Q3 Social Sciences Pub Date : 2019-08-27 DOI: 10.1515/ILS-2019-0007
C. Singh
Employers often face a plethora of issues in redundancy situations. Likewise, employees often fear or are overwhelmed by the prospect that they may be chosen for redundancy. Whilst these issues have been widely written about there is little discussion of “bumping.” When the issue appears in the employment tribunal, in cases such as Mirab v Mentor Graphics Limited, it is too late and the employer faces a successful unfair dismissal claim against it. Bumping occurs where an employer makes redundant a junior employee: one whose role has not identified as being at risk of redundancy. The result is that the more senior employee, one whose role was been identified as being at risk of redundancy, is placed into the junior role and therefore becomes subject to terms and conditions that are often less beneficial for example the junior role will inevitably come with a reduction in salary and/or perks. This article explores the legal issues that surround the instances in which an employer should consider “bumping,” its relationship with the band of reasonable responses and the resultant effect, if any, of failing to do so.
在裁员的情况下,雇主经常面临大量的问题。同样,员工经常担心或被裁员的前景淹没。虽然这些问题已经被广泛报道,但很少有关于“碰撞”的讨论。当这个问题出现在就业法庭上时,比如Mirab v Mentor Graphics Limited,为时已晚,雇主将面临成功的不公平解雇索赔。当雇主解雇了一名初级员工时,就会发生解雇:该员工的角色尚未被确定为有被解雇的风险。结果是,职位被确定为有裁员风险的高级员工被安排到初级职位,因此受到往往不太有利的条款和条件的约束——例如,初级职位将不可避免地减少工资和/或津贴。这篇文章探讨了雇主应该考虑“冲撞”的情况下的法律问题,它与合理回应的关系,以及不这样做的后果(如果有的话)。
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引用次数: 0
Legal Specifics of Bankruptcy Proceedings of Insurers in Ukraine 乌克兰保险公司破产程序的法律细节
Q3 Social Sciences Pub Date : 2018-08-28 DOI: 10.1515/ils-2018-0018
N. Patsuriia, Valeria V. Radzyviliuk, N. Fedorchenko, I. Kalaur, M. Bazhenov
Abstract Many countries adopted legal regulation of insolvency problems of insurers and rules for bankruptcy proceedings (insolvency) to mitigate and prevent consequences of bankruptcy and preserve the assets of insurance companies. To a certain extent, Ukraine follows the similar track. The authors describe the specifics of bankruptcy proceedings, defined by the laws of Ukraine on bankruptcy, and “complicated” by the legal status of the insurance company. On the basis of the analysis, the authors put forward a proposal to modernize bankruptcy law as part of the legal regulation of bankruptcy of insurers-debtors (bankrupts). It is established that the Law of Ukraine of 1992 provides for the possibility of applying a procedure of sanation to the insurers. The authors state that the specific legal consequences of the liquidation procedure and the recognition of a debtor as a bankrupt include the termination of all insurance contracts and sale of property. It has been established that the incoherence of bankruptcy laws of different countries is explained by different approaches to legal regulation.
摘要许多国家通过了关于保险公司破产问题的法律法规和破产程序(破产)规则,以减轻和防止破产的后果,并保护保险公司的资产。在某种程度上,乌克兰也走上了类似的道路。作者描述了乌克兰破产法定义的破产程序的细节,以及保险公司的法律地位所“复杂”的细节。在分析的基础上,作者提出了将破产法现代化作为保险公司债务人(破产人)破产法律规制的一部分的建议。1992年《乌克兰法》规定了对保险人适用疗养程序的可能性。提交人指出,清算程序和承认债务人为破产人的具体法律后果包括终止所有保险合同和出售财产。已经确定,不同国家破产法的不一致是由不同的法律监管方法解释的。
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引用次数: 1
Deconstructing the Opacity of Pari Passu Clause as a Pathway to Interpretative Clarity: Guidepost to Optimal Adjudicatory Outcomes 解构“同等权益条款”的不透明性:通往解释明晰之路:通往最佳裁决结果的路标
Q3 Social Sciences Pub Date : 2018-08-28 DOI: 10.1515/ils-2018-0002
C. Ajibo
Abstract The opacity that underlines the substantive content and interpretation of pari passu clause in financial contracting requires more clarity to ensure predictability for the contracting parties relying on it to access fund in the financial markets. The re-awakening of the contextual and textual controversy that underpins the clause by the NML case has once again re-enacted the divergent positions, namely: the broad or payment interpretation and narrow or equal ranking obligation. Consequently, there is a need for more clarity on the substantive content of the pari passu clause so that contracting parties will not be prejudiced in the event of dispute. Effectively, parties can achieve this by clarifying ex ante the applicable meaning of the clause. The contracting parties may state in the financial contractual agreement that the applicable meaning of the clause is a broad or payment interpretation. Alternatively, the contracting parties may adopt narrow interpretation; or entirely exclude the application of the pari passu clause. Also, parties may need to incorporate collective action clause (CAC) to ensure that the collective decisions of the majority of lenders prevail over undue proclivity for holdouts of the minority. This will dispel the possibility of controversy ex post over rateable payment, while ensuring orderly debt restructuring.
摘要金融合同中同等权益条款的实质内容和解释的不透明性要求更加明确,以确保依赖该条款的缔约方在金融市场上获取资金的可预测性。在NML案件中,支持该条款的上下文和文本争议的重新觉醒,再次制定了不同的立场,即:广义或支付解释和狭义或平等的等级义务。因此,有必要更明确地规定同等权益条款的实质性内容,以便在发生争端时不会使缔约各方受到损害。实际上,当事人可以通过事先澄清条款的适用含义来实现这一点。订约双方可在财务合同协议中声明,该条款的适用含义是广义解释或付款解释。或者,缔约各方可以采取狭义解释;或者完全排除同等权益条款的适用。此外,各方可能需要纳入集体行动条款(CAC),以确保大多数贷款人的集体决定优于少数人的不正当倾向。这将消除事后对应差饷付款产生争议的可能性,同时确保有序的债务重组。
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引用次数: 0
Death and the Dowry System: India’s Women and Female Children at Global Risk of Gendercide Over Money 死亡与嫁妆制度:印度妇女和女童因金钱而面临性别灭绝的全球风险
Q3 Social Sciences Pub Date : 2017-08-28 DOI: 10.1515/ILS-2016-0251
Devaki Monani, Felicity Gerry QC
Abstract Increasing globalization means that some actions or events transcend national boundaries and often require harmonization of responses. This is increasingly apparent in the context of violence against women and girls as movement of people and culture creates new challenges. News of accusations of dowry harassment against actress Smita Bansal caused a sensation in December 2015. The allegations arose during her brother’s divorce in London. It was suggested that her family had taken away jewelry and money from her sister-in-law during marriage to her brother. The allegations were refuted. True or otherwise, the issue of dowry has been catapulted onto the world stage. Whilst the demanding and giving of dowry has been effectively illegal in India since 1961 (The Dowry prohibition Act, 1961), the practice continues and has been exported globally with migration. No similar provisions appear outside India to protect extra territorial dowry demands or harassment. Research is scant but news reports suggest that women are burned, poisoned, beaten and forced to commit suicide. Female children suffer infanticide and foeticide when dowry is unpaid or deemed insufficient. This paper explores these issues.
日益全球化意味着一些行动或事件超越国界,往往需要协调一致的反应。这在暴力侵害妇女和女童的情况下日益明显,因为人口流动和文化流动带来了新的挑战。2015年12月,女演员Smita Bansal被控嫁妆骚扰的消息引起了轰动。这些指控是在她哥哥在伦敦离婚期间提出的。有人认为,她的家人在她嫂子嫁给她哥哥期间,从她嫂子那里拿走了珠宝和钱。这些指控被驳斥了。不管是否属实,嫁妆问题已经被推上了世界舞台。虽然自1961年以来,要求和给予嫁妆在印度实际上是非法的(1961年《嫁妆禁止法》),但这种做法仍在继续,并随着移民出口到全球。在印度以外没有类似的条款来保护域外的嫁妆要求或骚扰。研究很少,但新闻报道表明,妇女被烧死、下毒、殴打和被迫自杀。当嫁妆未付或被认为不足时,女婴遭受杀婴和杀胎。本文对这些问题进行了探讨。
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引用次数: 1
Legislating for Same-Sex Marriage: Sophistical Effectiveness in Australian Law 同性婚姻立法:澳大利亚法律的复杂效力
Q3 Social Sciences Pub Date : 2017-01-28 DOI: 10.1515/ils-2016-0260
G. Lilienthal
Abstract This paper by-passes the various public tropes, such as “marriage equality”, and concentrates on determining whether or not a same-sex marriage law would be sophistically effective in Australia. It revives the ancient Greek sophistical rhetorical skill of proposing a law, and applies it as a critical context to the topic of legislating for same-sex marriage. The objective is to assess whether or not a same-sex marriage law will be effective in its legislative objects. It proposes to discuss whether the parliament could introduce such a law so that the law’s objects were achieved effectively in the public mind. Argument will try to show that introducing a law to create same-sex marriage would fail because of subsisting priestly legislation on the subject of marriage. Its two hypotheses are that the canon law and other English priestly legislation restrict the scope of marriage regulation, and marriage could not be re-defined to cover same-sex marriage. Sections of the paper examining the law historically employ the historiographical method of identifying underlying norms, the effect of which is occasional reverse chronologies. The article’s conclusion will assert that a statute for legal and duly registered same-sex marriage likely would be, according to sophistical rhetorical reasoning, a fiction misrepresenting the truth of the subsisting legal and social institutions of marriage.
摘要本文绕过了各种公共比喻,如“婚姻平等”,并集中精力确定同性婚姻法在澳大利亚是否有效。它复活了古希腊提出法律的诡辩修辞技巧,并将其作为同性婚姻立法的关键背景。其目的是评估同性婚姻法的立法目标是否有效。它建议讨论议会是否可以出台这样一项法律,以便在公众心目中有效实现该法律的目标。争论将试图表明,引入一项建立同性婚姻的法律将失败,因为关于婚姻问题的牧师立法仍然存在。它的两个假设是,教会法和其他英国牧师立法限制了婚姻监管的范围,婚姻不能被重新定义为涵盖同性婚姻。论文的章节从历史上考察了法律,采用了史学方法来识别潜在的规范,其效果是偶尔出现倒计时。这篇文章的结论将断言,根据诡辩的修辞推理,合法和正式登记的同性婚姻法规很可能是一部虚构的小说,歪曲了现存的法律和社会婚姻制度的真相。
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引用次数: 0
Thou Shall Not Kill: The Constitutionality of Death Penalty Under Nigerian Legal System 你不应该杀人:尼日利亚法律制度下死刑的合宪性
Q3 Social Sciences Pub Date : 2017-01-22 DOI: 10.1515/ils-2017-0003
O. Duru, N. Nwafor, Chioma O. Nwabachili
Abstract Two wrongs cannot make a right; there is hardly any justification for the continual use of capital punishment (death) as a form of punishment in Nigeria. This paper will canvass that, even though death penalty is a constitutionally permissible form of punishment in Nigeria, but it goes against the recent positive and developmental strides in the areas of civilization, criminology and human right. The paper leans in favor of the abolitionist perspective by arguing that life imprisonment is as effective as the death penalty as a means of deterrence.
两个错误不能构成一个正确;在尼日利亚,几乎没有任何理由继续使用死刑(死亡)作为一种惩罚形式。本文将探讨,尽管死刑在尼日利亚是宪法允许的惩罚形式,但它违背了最近在文明、犯罪学和人权领域取得的积极和发展进步。本文倾向于废奴主义的观点,认为终身监禁作为一种威慑手段与死刑一样有效。
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引用次数: 0
From Apprentice to Paralegal: The Rise of the Paralegal Profession in America 从学徒到律师助理:美国律师助理职业的兴起
Q3 Social Sciences Pub Date : 2017-01-01 DOI: 10.1515/ILS-2016-0261
Robert E. Mongue
Abstract In 1980, the South Carolina Supreme Court noted, “Paralegals are routinely employed by licensed attorneys to assist in the preparation of legal documents such as deeds and mortgages.” According to the court, the activities of a paralegal were of a preparatory nature, such as legal research, investigation, or the composition of legal documents. This assessment of paralegal utilization in 1980 might well have been surprising to many readers of the court’s decision. As the delegation of legal work to non-lawyers evolved, so has the paralegal profession. The goal of this paper is to trace the transition of paralegals from a somewhat glorified – albeit very specialized – secretarial role to a professional position, emphasizing the period just before and after the creation of the ABA definition of the legal/assistant paralegal position. Legal professionals, rather than historians, provide most of historiography that is available. Historians appear to have focused on particular lawyers, especially those who became political leaders, and the efforts of persons other than white males to enter the profession with little mention of the personnel that supported those lawyers. Discussion of the historical development of paralegals and the paralegal profession has been limited to introductory chapters of practice manuals written by lawyers and paralegal educators for paralegals. The utilization of legal assistants from the 1970s to the present is well-documented, however, in contemporary writings by lawyers, law office managers, and social scientists. This paper is concerned with the development of the paralegal profession and the paralegal role in American law offices. This study examines writings from the twentieth century lawyers, paralegals, law office managers, paralegal educators, and social scientists to track the paralegal profession in five respects: (1) Definition of the nature of the role of the persons considered part of the occupation; (2) Establishment of educational requirements and forums; (3) Organization of professional associations; (4) Self-regulation; and, (5) Development of enforceable codes of professional conduct. In addition to the contemporary writings, the study uses information obtained through communications with paralegals, paralegal educators, and paralegal association directors who practiced during the 1970s, 1980s, and 1990s.
1980年,南卡罗来纳州最高法院指出,“律师助理通常被持牌律师雇用,以协助准备契约和抵押等法律文件。”根据法院的说法,律师助理的活动具有准备性质,例如法律研究,调查或法律文件的组成。这种对1980年律师助理使用情况的评估可能会让许多读过法院判决的读者感到惊讶。随着法律工作委托给非律师的发展,律师助理职业也在发展。本文的目标是追溯律师助理从某种程度上美化的——尽管非常专业的——秘书角色到专业职位的转变,强调在美国律师协会(ABA)对法律/助理律师助理职位的定义创建之前和之后的时期。法律专业人士,而不是历史学家,提供了大部分可用的历史编纂。历史学家似乎把注意力集中在特定的律师身上,尤其是那些后来成为政治领袖的律师,以及白人男性以外的人为进入律师行业所做的努力,而很少提及支持这些律师的人员。关于律师助理和律师助理职业的历史发展的讨论仅限于律师和律师助理教育者为律师助理编写的实践手册的介绍章节。然而,从20世纪70年代至今,法律助理的使用在当代律师、律师事务所经理和社会科学家的著作中得到了充分的记录。本文关注的是律师助理职业的发展和律师助理在美国律师事务所的作用。本研究考察了20世纪律师、律师助理、律师事务所经理、律师助理教育者和社会科学家的著作,从五个方面对律师助理职业进行了追踪:(1)定义了被认为是该职业一部分的人的角色性质;(2)建立教育要求和论坛;(三)专业协会的组织;(4)自律;(5)制定可执行的职业行为准则。除了当代著作之外,本研究还使用了通过与20世纪70年代、80年代和90年代执业的律师助理、律师助理教育者和律师助理协会主任交流获得的信息。
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引用次数: 0
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