Pub Date : 2021-06-30DOI: 10.47363/jonrr/2021(2)135
A. Kuchkuntla
{"title":"Sudden Abdominal Pain: A Unique Case of Metastatic Mixed Neuroendocrine and Adenocarcinoma of the Colon","authors":"A. Kuchkuntla","doi":"10.47363/jonrr/2021(2)135","DOIUrl":"https://doi.org/10.47363/jonrr/2021(2)135","url":null,"abstract":"","PeriodicalId":351114,"journal":{"name":"Journal of Oncology Research Review & Reports","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115558799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.47363/jonrr/2021(2)140
A. Kuchkuntla
Necrotizing fasciitis (NF) has a rapid clinical course and is associated with high mortality. Moreover, it involves a high index of suspicion and early aggressive intervention to reduce the risk of mortality. The overlap in clinical presentation in similar pathologies like abscesses, cellulitis, and deep vein thrombosis, can mask underlying NF, making the diagnosis even more challenging. This case presents multiple comorbidities that expedited the development of NF, while demonstrating a pragmatic approach to treating NF while balancing anticoagulation and emergent surgical intervention. The utilization of clinical judgement and a risk stratification score can help identify early cases of NF allowing for aggressive intervention.
{"title":"Utilization of Lrinec Score for Early Diagnosis of a Necrotizing Soft Tissue Infection by Serratia Marcesens Complicated with Deep Vein Thrombosis","authors":"A. Kuchkuntla","doi":"10.47363/jonrr/2021(2)140","DOIUrl":"https://doi.org/10.47363/jonrr/2021(2)140","url":null,"abstract":"Necrotizing fasciitis (NF) has a rapid clinical course and is associated with high mortality. Moreover, it involves a high index of suspicion and early aggressive intervention to reduce the risk of mortality. The overlap in clinical presentation in similar pathologies like abscesses, cellulitis, and deep vein thrombosis, can mask underlying NF, making the diagnosis even more challenging. This case presents multiple comorbidities that expedited the development of NF, while demonstrating a pragmatic approach to treating NF while balancing anticoagulation and emergent surgical intervention. The utilization of clinical judgement and a risk stratification score can help identify early cases of NF allowing for aggressive intervention.","PeriodicalId":351114,"journal":{"name":"Journal of Oncology Research Review & Reports","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125527279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.47363/jonrr/2021(2)138
A. Kuchkuntla
Castleman Disease (CD) is a spectrum of heterogenous hematological diseases that share characteristic clinical, histopathological, and immunological features. We present a case of a 61-y female with history of non-Hodgkin Lymphoma and hypothyroidism presenting with fatigue, generalized weakness, nausea, and poor appetite. On admission, physical examination was unremarkable, and labs were notable for hyperkalemia, hyperuricemia and worsening renal function. Imaging showed lymphadenopathy in neck, mediastinum, and left axilla along with mediastinal and retroperitoneal lymphadenopathy. Initial work up of serum electrophoresis was suggestive of multiple myeloma however bone scan did not reveal any lytic lesions. As biopsy results were pending, patient developed worsening cytopenia’s and a repeat serum electrophoresis showed a M spike with IgG lambda against a polyclonal background. Bone marrow biopsy showed polytypic plasmacytosis that was negative for HHV 8 and lymph node biopsy also showed polytypic plasmacytosis. Further work confirmed the diagnosis of idiopathic multicentric Castleman disease and patient was treated with silutuximab and responded well.
{"title":"Idiopathic Multicentric Castleman Disease","authors":"A. Kuchkuntla","doi":"10.47363/jonrr/2021(2)138","DOIUrl":"https://doi.org/10.47363/jonrr/2021(2)138","url":null,"abstract":"Castleman Disease (CD) is a spectrum of heterogenous hematological diseases that share characteristic clinical, histopathological, and immunological features. We present a case of a 61-y female with history of non-Hodgkin Lymphoma and hypothyroidism presenting with fatigue, generalized weakness, nausea, and poor appetite. On admission, physical examination was unremarkable, and labs were notable for hyperkalemia, hyperuricemia and worsening renal function. Imaging showed lymphadenopathy in neck, mediastinum, and left axilla along with mediastinal and retroperitoneal lymphadenopathy. Initial work up of serum electrophoresis was suggestive of multiple myeloma however bone scan did not reveal any lytic lesions. As biopsy results were pending, patient developed worsening cytopenia’s and a repeat serum electrophoresis showed a M spike with IgG lambda against a polyclonal background. Bone marrow biopsy showed polytypic plasmacytosis that was negative for HHV 8 and lymph node biopsy also showed polytypic plasmacytosis. Further work confirmed the diagnosis of idiopathic multicentric Castleman disease and patient was treated with silutuximab and responded well.","PeriodicalId":351114,"journal":{"name":"Journal of Oncology Research Review & Reports","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131737699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.47363/jonrr/2021(2)131
Ali Amanati
Persistent marrow aplasia is a rare complication with poor prognosis after intensive chemotherapy for acute myeloid leukemia. We present a 14-year-old boy with acute myeloid leukemia (AML), was complicated by chemotherapy induced persistent aplasia and he was expired because of prolonged neutropenia and pulmonary Aspergilosis. In this review we explain causes of persistent post chemotherapy persistent aplasia and prevention of this phenomenon during treatment with consideration of minimal residual disease (MRD) and response to question about chemotherapy titration dose.
{"title":"Is Need Chemotherapy Titration During Acute Myeloid Leukemia Treatment?","authors":"Ali Amanati","doi":"10.47363/jonrr/2021(2)131","DOIUrl":"https://doi.org/10.47363/jonrr/2021(2)131","url":null,"abstract":"Persistent marrow aplasia is a rare complication with poor prognosis after intensive chemotherapy for acute myeloid leukemia. We present a 14-year-old boy with acute myeloid leukemia (AML), was complicated by chemotherapy induced persistent aplasia and he was expired because of prolonged neutropenia and pulmonary Aspergilosis. In this review we explain causes of persistent post chemotherapy persistent aplasia and prevention of this phenomenon during treatment with consideration of minimal residual disease (MRD) and response to question about chemotherapy titration dose.","PeriodicalId":351114,"journal":{"name":"Journal of Oncology Research Review & Reports","volume":"39 14","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132364455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.47363/jonrr/2021(2)142
A. Kuchkuntla
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe and potentially fatal adverse hypersensitivity reaction often secondary to therapeutic medications. There is a wide variation in the incidence of the disease and is dependent on the genetic makeup of the individual. The most common presentation includes skin eruptions, fever, generalized lymphadenopathy, eosinophilia, and internal organ involvement (most commonly, liver, kidneys, and lungs). Some less common features are dysphagia, agranulocytosis, and chylous ascites. The most common drugs causing DRESS syndrome include carbamazepine, allopurinol, sulfasalazine, phenobarbital, and lamotrigine. Differential diagnosis has Steven-Johnson Syndrome/Toxic Epidermal Necrolysis, hypereosinophilic syndrome, and Sezary syndrome. Systemic corticosteroids are the first-line treatment for DRESS syndrome and the withdrawal of the offending agent and supportive therapy. We report a rare case of DRESS syndrome following the use of clarithromycin and moxifloxacin, where rapid steroid taper resulted in relapse.
{"title":"A Relapsing Case of Drug Reaction with Eosinophilia and Systemic Symptoms (Dress) Syndrome","authors":"A. Kuchkuntla","doi":"10.47363/jonrr/2021(2)142","DOIUrl":"https://doi.org/10.47363/jonrr/2021(2)142","url":null,"abstract":"Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe and potentially fatal adverse hypersensitivity reaction often secondary to therapeutic medications. There is a wide variation in the incidence of the disease and is dependent on the genetic makeup of the individual. The most common presentation includes skin eruptions, fever, generalized lymphadenopathy, eosinophilia, and internal organ involvement (most commonly, liver, kidneys, and lungs). Some less common features are dysphagia, agranulocytosis, and chylous ascites. The most common drugs causing DRESS syndrome include carbamazepine, allopurinol, sulfasalazine, phenobarbital, and lamotrigine. Differential diagnosis has Steven-Johnson Syndrome/Toxic Epidermal Necrolysis, hypereosinophilic syndrome, and Sezary syndrome. Systemic corticosteroids are the first-line treatment for DRESS syndrome and the withdrawal of the offending agent and supportive therapy. We report a rare case of DRESS syndrome following the use of clarithromycin and moxifloxacin, where rapid steroid taper resulted in relapse.","PeriodicalId":351114,"journal":{"name":"Journal of Oncology Research Review & Reports","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130359912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.47363/jonrr/2021(2)137
A. Kuchkuntla
Microangiopathic hemolytic anemias (MAHA) are secondary to damage of RBCs because of endothelial vascular damage of blood vessels leading to hemolysis. MAHAs are characterized by negative coombs test and are associated with several etiologies that include can be either hereditary complement or ADAMTS13 deficiency or sepsis or malignancy. Cancer associated MAHA (CA-MAHA) is a rare and is seen in patients with advanced metastatic disease. CA-MAHA has significant mortality rate and chemotherapy is the only therapeutic option, however overall survival is poor. Here we, present a rare case of CA-MAHA secondary to metastatic signet ring cell carcinoma with an unknown primary. In patients, when the cause of progressive MAHA is unknown, the possibility of cancer associated MAHA must be considered and a comprehensive work up for an underlying malignancy must be done.
{"title":"Cancer Associated Microangiopathic Hemolytic Anemia: A Rare Paraneoplastic Syndrome","authors":"A. Kuchkuntla","doi":"10.47363/jonrr/2021(2)137","DOIUrl":"https://doi.org/10.47363/jonrr/2021(2)137","url":null,"abstract":"Microangiopathic hemolytic anemias (MAHA) are secondary to damage of RBCs because of endothelial vascular damage of blood vessels leading to hemolysis. MAHAs are characterized by negative coombs test and are associated with several etiologies that include can be either hereditary complement or ADAMTS13 deficiency or sepsis or malignancy. Cancer associated MAHA (CA-MAHA) is a rare and is seen in patients with advanced metastatic disease. CA-MAHA has significant mortality rate and chemotherapy is the only therapeutic option, however overall survival is poor. Here we, present a rare case of CA-MAHA secondary to metastatic signet ring cell carcinoma with an unknown primary. In patients, when the cause of progressive MAHA is unknown, the possibility of cancer associated MAHA must be considered and a comprehensive work up for an underlying malignancy must be done.","PeriodicalId":351114,"journal":{"name":"Journal of Oncology Research Review & Reports","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122453390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.47363/jonrr/2021(2)133
A. Kuchkuntla, Aarathi Ardha Reddy
{"title":"Carcinoma of Pyriform Fossa with Mediastinal Metastasis Successfully Treated with Chemoradiotherapy","authors":"A. Kuchkuntla, Aarathi Ardha Reddy","doi":"10.47363/jonrr/2021(2)133","DOIUrl":"https://doi.org/10.47363/jonrr/2021(2)133","url":null,"abstract":"","PeriodicalId":351114,"journal":{"name":"Journal of Oncology Research Review & Reports","volume":"2 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120908268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.47363/jonrr/2021(2)139
K. Yammine, S. Khalife
Tumor thrombus infiltration of hepatocellular carcinoma (HCC) into the inferior vena cava and right atrium is rare and is associated with a poor prognosis due to the critical location of the tumor and the limited efficiency of the available treatment strategies. In this study, we report the case of a patient with advanced HCC and tumor thrombus in the inferior vena cava and right atrium who demonstrated complete response with mass retraction upon Yttrium-90 trans-arterial radioembolization (90Y- TARE) therapy. Throughout the 16 months follow-ups after the radioembolization, the patient was free of any complications, revealing no occurrence of radiation-induced pneumonitis or tumor recurrence.
{"title":"Transarterial Radioembolization Treatment of Advanced Hepatocellular Carcinoma Invading the Right Atrium","authors":"K. Yammine, S. Khalife","doi":"10.47363/jonrr/2021(2)139","DOIUrl":"https://doi.org/10.47363/jonrr/2021(2)139","url":null,"abstract":"Tumor thrombus infiltration of hepatocellular carcinoma (HCC) into the inferior vena cava and right atrium is rare and is associated with a poor prognosis due to the critical location of the tumor and the limited efficiency of the available treatment strategies. In this study, we report the case of a patient with advanced HCC and tumor thrombus in the inferior vena cava and right atrium who demonstrated complete response with mass retraction upon Yttrium-90 trans-arterial radioembolization (90Y- TARE) therapy. Throughout the 16 months follow-ups after the radioembolization, the patient was free of any complications, revealing no occurrence of radiation-induced pneumonitis or tumor recurrence.","PeriodicalId":351114,"journal":{"name":"Journal of Oncology Research Review & Reports","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125151212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.47363/jonrr/2021(2)141
Dormar David Barrios Martínez
The wide use of pulmonary and cardiac ultrasound in critical medicine allows early diagnoses and the performance of certain procedures that achieve a prompt intervention in a type of patient who does not wait. Thoracentesis is a percutaneous procedure for collecting pleural fluid, and it has diagnostic utility and therapeutic applications. The use of ultrasound to perform an evacuative and diagnostic thoracentesis has proven to be a simple, safe, low-cost, and especially reproducible procedure in personnel under training and with training already established. We present an algorithm on the realization of a successful Thoracentesis Guided by Focused Ultrasonography Performed by the Intensivist Physician in Malignant Pleural Effusion, which is based on different protocols of daily practice in intensive care units. This algorithm follows certain steps and with good performance for the identification of pleural effusion, catheter passage and drainage of the effusion.
{"title":"Thoracentesis Guided By Focused Ultrasonography Performed By the Intensivist Physician in Malignant Pleural Effusion: A Safe Strategy","authors":"Dormar David Barrios Martínez","doi":"10.47363/jonrr/2021(2)141","DOIUrl":"https://doi.org/10.47363/jonrr/2021(2)141","url":null,"abstract":"The wide use of pulmonary and cardiac ultrasound in critical medicine allows early diagnoses and the performance of certain procedures that achieve a prompt intervention in a type of patient who does not wait. Thoracentesis is a percutaneous procedure for collecting pleural fluid, and it has diagnostic utility and therapeutic applications. The use of ultrasound to perform an evacuative and diagnostic thoracentesis has proven to be a simple, safe, low-cost, and especially reproducible procedure in personnel under training and with training already established. We present an algorithm on the realization of a successful Thoracentesis Guided by Focused Ultrasonography Performed by the Intensivist Physician in Malignant Pleural Effusion, which is based on different protocols of daily practice in intensive care units. This algorithm follows certain steps and with good performance for the identification of pleural effusion, catheter passage and drainage of the effusion.","PeriodicalId":351114,"journal":{"name":"Journal of Oncology Research Review & Reports","volume":"5 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114092606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.47363/jonrr/2021(2)134
H. Al-Shamsi
Objective: This cross-sectional study aims to report the clinicopathological features of Gulf Cooperation Council (GCC) patients with Gastric Cancer (GC). Patients and Methods: This cross-sectional study evaluated patients from GCC countries presenting with GC, treated at the University of Texas MD Anderson Cancer Center, Houston, Texas from 1981 to 2015. After obtaining an Institutional Review Board (IRB) approval to conduct this cross-sectional study, the data were collected from the charts of 96 consecutive GCC patients diagnosed with GC according to electronic and paper medical records (for cases prior to the implementation of the electronic medical records): The charts were reviewed for demographic data, clinical data, diagnostic tools, endoscopic location of the tumour and clinicopathological features of the GC. Statistical analyses were performed by using SPSS version 20. Numerical data were presented as mean +/- standard deviation (SD) (For normally distributed data); median and range (For not normally distributed data). Nominal data were expressed by percentages. Results: 96 patients identified with histologically confirmed gastric carcinoma from Saudi Arabia (KSA) (40%), UAE (26%), Qatar (16%) Kuwait (10%), Oman (3%) and Bahrain (2%). The median age was 54.5 years and 40 patients (42%) were less than 50 years of age. 61% of the patients were of male gender and 39% were female. Intestinal type was the most common histological type in 61% of cases, 30% had signet cell histology. The aggressive signet ring histology is the most common (71.4%) in younger patients (Age < 50) in this cohort. Out of those 28 patients tested for HER-2 amplification, 6 (20%) were found to be amplified. Finally, 76% of the patients presented with stage IV disease. Conclusion: GC tends to present in advanced stages in GCC population with median duration from first symptoms to diagnosis was 9.3 months (2 to 18 months). GC in patients from GCC countries is diagnosed at 10 years earlier than in Western population. Intestinal‐type histology is most common similar to the western population, yet aggressive histology (signet ring) is high in younger population. HER-2 amplification rate is similar to Western populations. This is the first study to report these findings in GCC population with gastric cancer. Further collaboration and research are needed across the GCC countries to better characterize GC in this region and to understand the early onset pattern of GC observed in this report.
目的:本横断面研究旨在报道海湾合作委员会(GCC)患者胃癌(GC)的临床病理特征。患者和方法:本横断面研究评估了1981年至2015年在德克萨斯州休斯顿的德克萨斯大学MD安德森癌症中心接受治疗的GCC国家的GC患者。在获得机构审查委员会(IRB)批准进行这项横断面研究后，根据电子和纸质病历(在实施电子病历之前的病例)从96例连续诊断为胃癌的GCC患者的图表中收集数据:对图表进行人口统计数据、临床数据、诊断工具、内镜下肿瘤位置和胃癌的临床病理特征的审查。采用SPSS version 20进行统计分析。数值数据以均数+/-标准差(SD)表示(对于正态分布数据);中位数和范围(对于非正态分布的数据)。名义数据以百分比表示。结果:96例经组织学证实的胃癌患者分别来自沙特阿拉伯(KSA)(40%)、阿联酋(26%)、卡塔尔(16%)、科威特(10%)、阿曼(3%)和巴林(2%)。中位年龄为54.5岁，40例(42%)患者年龄小于50岁。男性占61%，女性占39%。肠型是最常见的组织学类型，占61%，30%为印细胞组织学。在该队列中，年轻患者(年龄< 50岁)中侵袭性印戒组织学最常见(71.4%)。在检测HER-2扩增的28例患者中，6例(20%)被发现扩增。最后，76%的患者表现为IV期疾病。结论:GCC人群中GC倾向于出现在晚期，从首次症状到诊断的中位病程为9.3个月(2 ~ 18个月)。GCC国家患者的胃癌诊断时间比西方人群早10年。肠型组织学最常见，与西方人群相似，但侵袭性组织学(印戒)在年轻人群中较高。HER-2扩增率与西方人群相似。这是首次在GCC人群胃癌患者中报道这些发现。海湾合作委员会各国需要进一步合作和研究，以更好地描述该地区的GC特征，并了解本报告中观察到的GC早期发病模式。
{"title":"Clinicopathological Features of Gastric Cancer in a Cohort of Gulf Council Countries’ Patients: A Cross-Sectional Study of 96 Cases","authors":"H. Al-Shamsi","doi":"10.47363/jonrr/2021(2)134","DOIUrl":"https://doi.org/10.47363/jonrr/2021(2)134","url":null,"abstract":"Objective: This cross-sectional study aims to report the clinicopathological features of Gulf Cooperation Council (GCC) patients with Gastric Cancer (GC). Patients and Methods: This cross-sectional study evaluated patients from GCC countries presenting with GC, treated at the University of Texas MD Anderson Cancer Center, Houston, Texas from 1981 to 2015. After obtaining an Institutional Review Board (IRB) approval to conduct this cross-sectional study, the data were collected from the charts of 96 consecutive GCC patients diagnosed with GC according to electronic and paper medical records (for cases prior to the implementation of the electronic medical records): The charts were reviewed for demographic data, clinical data, diagnostic tools, endoscopic location of the tumour and clinicopathological features of the GC. Statistical analyses were performed by using SPSS version 20. Numerical data were presented as mean +/- standard deviation (SD) (For normally distributed data); median and range (For not normally distributed data). Nominal data were expressed by percentages. Results: 96 patients identified with histologically confirmed gastric carcinoma from Saudi Arabia (KSA) (40%), UAE (26%), Qatar (16%) Kuwait (10%), Oman (3%) and Bahrain (2%). The median age was 54.5 years and 40 patients (42%) were less than 50 years of age. 61% of the patients were of male gender and 39% were female. Intestinal type was the most common histological type in 61% of cases, 30% had signet cell histology. The aggressive signet ring histology is the most common (71.4%) in younger patients (Age < 50) in this cohort. Out of those 28 patients tested for HER-2 amplification, 6 (20%) were found to be amplified. Finally, 76% of the patients presented with stage IV disease. Conclusion: GC tends to present in advanced stages in GCC population with median duration from first symptoms to diagnosis was 9.3 months (2 to 18 months). GC in patients from GCC countries is diagnosed at 10 years earlier than in Western population. Intestinal‐type histology is most common similar to the western population, yet aggressive histology (signet ring) is high in younger population. HER-2 amplification rate is similar to Western populations. This is the first study to report these findings in GCC population with gastric cancer. Further collaboration and research are needed across the GCC countries to better characterize GC in this region and to understand the early onset pattern of GC observed in this report.","PeriodicalId":351114,"journal":{"name":"Journal of Oncology Research Review & Reports","volume":"139 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116628593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：