Pub Date : 2023-03-31DOI: 10.24293/ijcpml.v29i2.1987
Nur Afiah, I. Handayani, N. A. Kadir
Community-Acquired Pneumonia (CAP) is an acute infection with high morbidity and mortality, especially among toddlers and elders in Indonesia. Culture is the gold standard for infectious diseases, which requires a long time. Therefore, a rapid, inexpensive, easy-to-use marker such as NLR is needed. To analyze the relationship of NLR and culture results with the clinical severity of CAP. A retrospective study with a cross-sectional design was performed using secondary data from CAP patients at Dr. Wahidin Sudirohusodo Hospital from January 1st, 2018 to July 31st, 2021. The study conducted on 113 samples showed no significant differences between NLR and clinical severity of CAP (p-value of 0.071). However, the mean value of NLR in severe CAP was higher (6±4.74) than in moderate CAP (2.58±1.8) with no significant correlation (p-value 0.071). There was a significant difference in culture on the clinical severity of CAP (p-value 0.005). A positive correlation was found between culture and clinical severity of CAP (p-value 0.004) with weak correlation strength (r=0.266). NLR is an early detection marker of infection. Stimulation of growth hormone causes an increase in neutrophil count, apoptosis acceleration, and lymphocyte redistribution; therefore, increased neutrophils are common in severe clinical conditions. The insignificant relationship between NLR and clinical severity might be caused by the therapeutic intervention given. The ATS/IDSA guidelines stated that culture results were positive in 4-15%. The mean NLR value in severe CAP was slightly higher than that of moderate CAP, but no significant difference was found. There was a weak correlation between culture results and the clinical severity of CAP patients.
{"title":"Analysis of Neutrophil/Lymphocyte Ratio and Culture Results on Clinical Severity of Patients with CAP","authors":"Nur Afiah, I. Handayani, N. A. Kadir","doi":"10.24293/ijcpml.v29i2.1987","DOIUrl":"https://doi.org/10.24293/ijcpml.v29i2.1987","url":null,"abstract":"Community-Acquired Pneumonia (CAP) is an acute infection with high morbidity and mortality, especially among toddlers and elders in Indonesia. Culture is the gold standard for infectious diseases, which requires a long time. Therefore, a rapid, inexpensive, easy-to-use marker such as NLR is needed. To analyze the relationship of NLR and culture results with the clinical severity of CAP. A retrospective study with a cross-sectional design was performed using secondary data from CAP patients at Dr. Wahidin Sudirohusodo Hospital from January 1st, 2018 to July 31st, 2021. The study conducted on 113 samples showed no significant differences between NLR and clinical severity of CAP (p-value of 0.071). However, the mean value of NLR in severe CAP was higher (6±4.74) than in moderate CAP (2.58±1.8) with no significant correlation (p-value 0.071). There was a significant difference in culture on the clinical severity of CAP (p-value 0.005). A positive correlation was found between culture and clinical severity of CAP (p-value 0.004) with weak correlation strength (r=0.266). NLR is an early detection marker of infection. Stimulation of growth hormone causes an increase in neutrophil count, apoptosis acceleration, and lymphocyte redistribution; therefore, increased neutrophils are common in severe clinical conditions. The insignificant relationship between NLR and clinical severity might be caused by the therapeutic intervention given. The ATS/IDSA guidelines stated that culture results were positive in 4-15%. The mean NLR value in severe CAP was slightly higher than that of moderate CAP, but no significant difference was found. There was a weak correlation between culture results and the clinical severity of CAP patients.","PeriodicalId":354500,"journal":{"name":"Indonesian Journal of Clinical Pathology and Medical Laboratory","volume":"53 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127506018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.24293/ijcpml.v29i2.1978
Nanda Amelia, T. Esa
Inflammatory process plays a role in the prognosis and development of Acute Coronary Syndrome (ACS). Inflammation parameters associated with ACS mortality are Monocyte/Lymphocyte ratio (MLR) and Monocyte/High Density Lipoprotein ratio (MHR). This study aimed to analyze MLR and MHR as predictors of ACS mortality based on the GRACE score. A cross-sectional retrospective study on ACS patients at Dr. Wahidin Sudirohusodo Makassar for the period January 2019-December 2020. Acute coronary syndrome patients were grouped into low, medium and high risk based on the GRACE score. Monocyte/lymphocyte ratio and MHR were measured on admission. The Kolmogorov-Smirnov test, Kruskal-Wallis test, Spearman's correlation test and Receiver Operating Characteristics (ROC) statistical tests were used. The statistical test results were significant if the p-value < 0.05. The sample consisted of 422 ACS patients, 70 low risk patients, 156 medium risk and 196 high risk patients. Age range 30–88 years. The mean MLR 0.50±0.37 and MHR 0.19±0.15. The mean MLR was the highest significant at high risk (0.58) and the lowest at low risk (0.37) (p<0.001); while MHR was not significant. Monocyte/lymphocyte ratio was positively correlated with GRACE score (p < 0.001), while MHR was not correlated (p 0.310). From the MLR ROC curve, the cut-off was 0.35 (AUC 0.673; 95% CI 0.695-0.742). MLR values increase in high-risk patients due to the ongoing inflammatory process. The MHR value did not show a positive correlation with mortality. Monocyte/lymphocyte ratio had a predictive value on mortality with a cut-off of 0.35 while the role of MHR still requires further research.
{"title":"Analysis of Monocyte/Lymphocyte Ratio and Monocyte/HDL Ratio as A Predictor of Mortality in ACS","authors":"Nanda Amelia, T. Esa","doi":"10.24293/ijcpml.v29i2.1978","DOIUrl":"https://doi.org/10.24293/ijcpml.v29i2.1978","url":null,"abstract":"Inflammatory process plays a role in the prognosis and development of Acute Coronary Syndrome (ACS). Inflammation parameters associated with ACS mortality are Monocyte/Lymphocyte ratio (MLR) and Monocyte/High Density Lipoprotein ratio (MHR). This study aimed to analyze MLR and MHR as predictors of ACS mortality based on the GRACE score. A cross-sectional retrospective study on ACS patients at Dr. Wahidin Sudirohusodo Makassar for the period January 2019-December 2020. Acute coronary syndrome patients were grouped into low, medium and high risk based on the GRACE score. Monocyte/lymphocyte ratio and MHR were measured on admission. The Kolmogorov-Smirnov test, Kruskal-Wallis test, Spearman's correlation test and Receiver Operating Characteristics (ROC) statistical tests were used. The statistical test results were significant if the p-value < 0.05. The sample consisted of 422 ACS patients, 70 low risk patients, 156 medium risk and 196 high risk patients. Age range 30–88 years. The mean MLR 0.50±0.37 and MHR 0.19±0.15. The mean MLR was the highest significant at high risk (0.58) and the lowest at low risk (0.37) (p<0.001); while MHR was not significant. Monocyte/lymphocyte ratio was positively correlated with GRACE score (p < 0.001), while MHR was not correlated (p 0.310). From the MLR ROC curve, the cut-off was 0.35 (AUC 0.673; 95% CI 0.695-0.742). MLR values increase in high-risk patients due to the ongoing inflammatory process. The MHR value did not show a positive correlation with mortality. Monocyte/lymphocyte ratio had a predictive value on mortality with a cut-off of 0.35 while the role of MHR still requires further research.","PeriodicalId":354500,"journal":{"name":"Indonesian Journal of Clinical Pathology and Medical Laboratory","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129126228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.24293/ijcpml.v29i2.1993
T. Triyono, U. Sukorini, Rukmono Siswishanto
The worldwide pandemic of Coronavirus Disease 2019 (COVID-19) has a major implication for blood donation. The beginning of the pandemic occurred at the same time as Ramadhan fasting. This study aimed to evaluate blood donation, blood use trends, and several factors associated with the need for transfusion during the COVID-19 pandemic and Ramadhan fasting in Dr. Sardjito General Hospital (SGH). Information on blood donation and the use of blood components in the SGH-Blood Centre (SGH-BC) from 1 February to 30 September 2019 and 2020 were collected and analyzed. The average number of blood donations from February to September 2020 declined by 11.22% compared to the previous year. The average use of blood components from February to May 2020 also declined compared to the previous year. the decline found in this study was Packed Red Cells (PRC) by 15.43%; Thrombocyte Concentrate (TC) by 23.03%; Whole Blood (WB) by 73.64%; Fresh Frozen Plasma (FFP) by 10.56%; and Thrombocyte Apheresis (TA) by 32.87%. Two characteristics of donors remain unchanged between 2019 and 2020. Most of them were males and age younger than 25 years old. However, there was a shifting characteristic of donors in blood group, weight, and hemoglobin level. Declined number of blood donations might be caused by the pandemic situation and Ramadhan fasting. Blood usage also decreased in the early of this pandemic. The SGH-BC had modified some strategies to increase blood donation and decrease blood component use in this situation.
{"title":"Blood Supply Management During COVID-19 Pandemic and Ramadhan Fasting at a Tertiary Hospital","authors":"T. Triyono, U. Sukorini, Rukmono Siswishanto","doi":"10.24293/ijcpml.v29i2.1993","DOIUrl":"https://doi.org/10.24293/ijcpml.v29i2.1993","url":null,"abstract":"The worldwide pandemic of Coronavirus Disease 2019 (COVID-19) has a major implication for blood donation. The beginning of the pandemic occurred at the same time as Ramadhan fasting. This study aimed to evaluate blood donation, blood use trends, and several factors associated with the need for transfusion during the COVID-19 pandemic and Ramadhan fasting in Dr. Sardjito General Hospital (SGH). Information on blood donation and the use of blood components in the SGH-Blood Centre (SGH-BC) from 1 February to 30 September 2019 and 2020 were collected and analyzed. The average number of blood donations from February to September 2020 declined by 11.22% compared to the previous year. The average use of blood components from February to May 2020 also declined compared to the previous year. the decline found in this study was Packed Red Cells (PRC) by 15.43%; Thrombocyte Concentrate (TC) by 23.03%; Whole Blood (WB) by 73.64%; Fresh Frozen Plasma (FFP) by 10.56%; and Thrombocyte Apheresis (TA) by 32.87%. Two characteristics of donors remain unchanged between 2019 and 2020. Most of them were males and age younger than 25 years old. However, there was a shifting characteristic of donors in blood group, weight, and hemoglobin level. Declined number of blood donations might be caused by the pandemic situation and Ramadhan fasting. Blood usage also decreased in the early of this pandemic. The SGH-BC had modified some strategies to increase blood donation and decrease blood component use in this situation.","PeriodicalId":354500,"journal":{"name":"Indonesian Journal of Clinical Pathology and Medical Laboratory","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124167188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-19DOI: 10.24293/ijcpml.v29i1.1960
Linda Mayliana Kusumaningrum Nurtadjudin, I. Handayani, Agus Alim Abdullah, M. Arif
Sepsis is one of the main causes of mortality in the intensive care unit. The SOFA score is used to assess organ dysfunction. There are several markers of sepsis such as the combination of RDW, PDW, and NLR to help predict the outcome of sepsis. To determine the role of RDW, PDW, and NLR associated with SOFA scores as prognostic markers in sepsis. A retrospective study with a cross-sectional approach has been conducted using secondary data from the medical records of sepsis patients from January 2018 to December 31, 2020, who met the inclusion criteria and were admitted to the ICU of Dr. Wahidin Sudirohusodo Hospital, Makassar. The sample size was 109 people consisting of 62 (56.9%) males and 47 (43.1%) females. The highest age range is 56–65 years (37.6%). A total of 97 people (89%) died and 12 (11%) improved. There is a positive correlation between changes in RDW and changes in SOFA scores (p=0.031), there is a positive correlation between changes in PDW and changes in SOFA scores (p=0.000), and there is a positive correlation between changes in NLR and changes in SOFA scores (p=0.000). The increase of RDW caused by systemic inflammation can predict disease progression. The state of increased proinflammatory cytokines inhibits the proliferation and maturation of erythrocytes; hence, it causes an increase in RDW. The acceleration of platelet destruction due to the suppression of cytokines in the bone marrow increases PDW. The increase in NLR occurs due to the rise in the inflammatory response, which results in suppressed cellular immunity. RDW, PDW, and NLR are positively correlated with changes in SOFA scores. PDW and NLR have a significant correlation with the outcome. RDW, PDW, and NLR can be used as prognostic markers in septic patients
{"title":"The Correlation between RDW, PDW, and NLR with the SOFA Score in Septic Patients","authors":"Linda Mayliana Kusumaningrum Nurtadjudin, I. Handayani, Agus Alim Abdullah, M. Arif","doi":"10.24293/ijcpml.v29i1.1960","DOIUrl":"https://doi.org/10.24293/ijcpml.v29i1.1960","url":null,"abstract":"Sepsis is one of the main causes of mortality in the intensive care unit. The SOFA score is used to assess organ dysfunction. There are several markers of sepsis such as the combination of RDW, PDW, and NLR to help predict the outcome of sepsis. To determine the role of RDW, PDW, and NLR associated with SOFA scores as prognostic markers in sepsis. A retrospective study with a cross-sectional approach has been conducted using secondary data from the medical records of sepsis patients from January 2018 to December 31, 2020, who met the inclusion criteria and were admitted to the ICU of Dr. Wahidin Sudirohusodo Hospital, Makassar. The sample size was 109 people consisting of 62 (56.9%) males and 47 (43.1%) females. The highest age range is 56–65 years (37.6%). A total of 97 people (89%) died and 12 (11%) improved. There is a positive correlation between changes in RDW and changes in SOFA scores (p=0.031), there is a positive correlation between changes in PDW and changes in SOFA scores (p=0.000), and there is a positive correlation between changes in NLR and changes in SOFA scores (p=0.000). The increase of RDW caused by systemic inflammation can predict disease progression. The state of increased proinflammatory cytokines inhibits the proliferation and maturation of erythrocytes; hence, it causes an increase in RDW. The acceleration of platelet destruction due to the suppression of cytokines in the bone marrow increases PDW. The increase in NLR occurs due to the rise in the inflammatory response, which results in suppressed cellular immunity. RDW, PDW, and NLR are positively correlated with changes in SOFA scores. PDW and NLR have a significant correlation with the outcome. RDW, PDW, and NLR can be used as prognostic markers in septic patients","PeriodicalId":354500,"journal":{"name":"Indonesian Journal of Clinical Pathology and Medical Laboratory","volume":"115 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123236082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-19DOI: 10.24293/ijcpml.v29i1.1943
R. Livia, Fajar Wasilah, Leni Lismayanti
Low Birth Weight (LBW) newborns face a risk of iron deficiency. Iron deficiency hinders growth, and motoric, and cognitive development. Newborns with LBW sometimes suffer from inflammation, which affects the commonly used iron measurements. Reticulocyte hemoglobin equivalent (Ret-He) is considered a potential tool to measure iron profile because it measures functional iron, and it is not affected by inflammation. This study compared the Ret-He in LBW and normal birth weight newborns. This cross-sectional study was done retrospectively by observing and comparing the hematology data of newborns from November to December 2019. The difference in Ret-He level was assessed using a non-parametric test. Out of 70 newborns, 26 were normal and 44 were LBW. The proportion of LBW newborns with anemia was higher than the proportion of normal ones (29.6% vs 7.7%, p=0.03). The median value of Ret-He in LBW was lower compared to normal birth weight (32.6 vs 33.3 pg, p=0.09), however, the values were still within the normal limits. Five from 70 of these newborns' Ret-He levels were under the reference range (7.14%). There was found that CRP levels were higher in LBW newborns than normal ones (5.6% vs 5%, p=0.98). There was a positive correlation between Ret-He and the birth weight of the newborns (r= 0.34, p =<0.01). There was no significant difference in Ret-He levels of LBW compared to normal babies. Further research is needed with a larger sample size to better assess the association of Ret-He and iron profiles in newborns.
低出生体重(LBW)新生儿面临缺铁的风险。缺铁会阻碍生长、运动和认知能力的发展。患有LBW的新生儿有时会出现炎症，这会影响常用的铁测量。网织红细胞血红蛋白当量(Ret-He)被认为是测量铁谱的潜在工具，因为它测量的是功能性铁，而且不受炎症的影响。本研究比较了低体重新生儿和正常出生体重新生儿的Ret-He。本横断面研究回顾性观察并比较2019年11月至12月新生儿血液学资料。采用非参数检验评估Ret-He水平的差异。70名新生儿中，26名正常，44名低体重新生儿。低体重新生儿贫血比例高于正常新生儿(29.6% vs 7.7%， p=0.03)。与正常出生体重相比，低体重儿的Ret-He中位数较低(32.6 vs 33.3 pg, p=0.09)，但仍在正常范围内。70例新生儿中有5例Ret-He水平低于参考范围(7.14%)。研究发现，低体重新生儿CRP水平高于正常新生儿(5.6% vs 5%， p=0.98)。Ret-He与新生儿出生体重呈正相关(r= 0.34, p =<0.01)。与正常婴儿相比，LBW的Ret-He水平无显著差异。进一步的研究需要更大的样本量，以更好地评估Ret-He与新生儿铁谱的关系。
{"title":"Comparison of Reticulocyte Hemoglobin Equivalent Levels between Low and Normal Birth Weight Newborns","authors":"R. Livia, Fajar Wasilah, Leni Lismayanti","doi":"10.24293/ijcpml.v29i1.1943","DOIUrl":"https://doi.org/10.24293/ijcpml.v29i1.1943","url":null,"abstract":"Low Birth Weight (LBW) newborns face a risk of iron deficiency. Iron deficiency hinders growth, and motoric, and cognitive development. Newborns with LBW sometimes suffer from inflammation, which affects the commonly used iron measurements. Reticulocyte hemoglobin equivalent (Ret-He) is considered a potential tool to measure iron profile because it measures functional iron, and it is not affected by inflammation. This study compared the Ret-He in LBW and normal birth weight newborns. This cross-sectional study was done retrospectively by observing and comparing the hematology data of newborns from November to December 2019. The difference in Ret-He level was assessed using a non-parametric test. Out of 70 newborns, 26 were normal and 44 were LBW. The proportion of LBW newborns with anemia was higher than the proportion of normal ones (29.6% vs 7.7%, p=0.03). The median value of Ret-He in LBW was lower compared to normal birth weight (32.6 vs 33.3 pg, p=0.09), however, the values were still within the normal limits. Five from 70 of these newborns' Ret-He levels were under the reference range (7.14%). There was found that CRP levels were higher in LBW newborns than normal ones (5.6% vs 5%, p=0.98). There was a positive correlation between Ret-He and the birth weight of the newborns (r= 0.34, p =<0.01). There was no significant difference in Ret-He levels of LBW compared to normal babies. Further research is needed with a larger sample size to better assess the association of Ret-He and iron profiles in newborns.","PeriodicalId":354500,"journal":{"name":"Indonesian Journal of Clinical Pathology and Medical Laboratory","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116020475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-19DOI: 10.24293/ijcpml.v29i1.1967
N. Tristina, Juandika Juandika, Leni Lismayanti, A. Sugianli, Raja Iqbal Mulya Harahap
 C-peptide is part of the, which its amounts were equal to endogenous insulin secreted by pancreatic β cells. Carboplatin is one of the chemotherapy regimens that are widely used to treat gynecological malignancies. Carboplatin may cause the damage of β-islets of Langerhans, which may cause defects in insulin synthesis leading to secondary diabetes mellitus or other types of diabetes mellitus. The purpose of this study was to determine the differences in C-peptide, (which reflects endogenous insulin levels) levels in patients with gynecologic malignancy who underwent carboplatin chemotherapy. This study was a comparative observational study with a cross-sectional design. There was a total of 42 subjects who met the inclusion criteria. Subjects with gynecological malignancy post-carboplatin chemotherapy regimens had lower serum C-peptide levels in group II compared to group I. Serum C-peptide levels can further be used to monitor side effects of carboplatin and can be used as a test to diagnose the other types of diabetes mellitus especially before starting the fourth cycle
 c肽是胰岛素的一部分，其数量相当于胰腺β细胞分泌的内源性胰岛素。卡铂是目前广泛应用于妇科恶性肿瘤治疗的化疗方案之一。卡铂可引起郎格汉斯β-胰岛的损伤，这可能导致胰岛素合成缺陷，导致继发性糖尿病或其他类型的糖尿病。本研究的目的是确定妇科恶性肿瘤患者在卡铂化疗后c肽(反映内源性胰岛素水平)水平的差异。本研究为横断面设计的比较观察性研究。共有42名受试者符合纳入标准。卡铂化疗后妇科恶性肿瘤患者血清c肽水平II组低于i组。血清c肽水平可进一步用于监测卡铂的副作用，并可作为诊断其他类型糖尿病的测试，特别是在第四个周期开始之前
{"title":"Analysis of C-Peptide Levels Among Gynaecological Malignancies Patients Underwent Chemotherapy with Carboplatin Regiment","authors":"N. Tristina, Juandika Juandika, Leni Lismayanti, A. Sugianli, Raja Iqbal Mulya Harahap","doi":"10.24293/ijcpml.v29i1.1967","DOIUrl":"https://doi.org/10.24293/ijcpml.v29i1.1967","url":null,"abstract":" C-peptide is part of the, which its amounts were equal to endogenous insulin secreted by pancreatic β cells. Carboplatin is one of the chemotherapy regimens that are widely used to treat gynecological malignancies. Carboplatin may cause the damage of β-islets of Langerhans, which may cause defects in insulin synthesis leading to secondary diabetes mellitus or other types of diabetes mellitus. The purpose of this study was to determine the differences in C-peptide, (which reflects endogenous insulin levels) levels in patients with gynecologic malignancy who underwent carboplatin chemotherapy. This study was a comparative observational study with a cross-sectional design. There was a total of 42 subjects who met the inclusion criteria. Subjects with gynecological malignancy post-carboplatin chemotherapy regimens had lower serum C-peptide levels in group II compared to group I. Serum C-peptide levels can further be used to monitor side effects of carboplatin and can be used as a test to diagnose the other types of diabetes mellitus especially before starting the fourth cycle","PeriodicalId":354500,"journal":{"name":"Indonesian Journal of Clinical Pathology and Medical Laboratory","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116635474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-19DOI: 10.24293/ijcpml.v29i1.2029
Victoria Mayasari, Yessy Puspitasari
Both Non-Alcoholic Fatty Liver Disease (NAFLD) and metabolic syndrome are health problems worldwide. Various studies suggest that NAFLD and metabolic syndrome have a two-way relationship. Metabolic syndrome can be preceded by NAFLD and NAFLD can be a manifestation of the metabolic syndrome. Because of the relationship between the two, the diagnosis and management of NAFLD and metabolic syndrome are important to prevent complications such as cardiovascular disease, liver cirrhosis, and malignancy. The diagnosis of metabolic syndrome can be made based on various diagnostic criteria determined by several health organizations, such as WHO, IDF, and NCEP-ATP. Since NAFLD is asymptomatic until advanced disease, many patients are only identified at advanced stages. Liver biopsy is currently the gold standard for diagnosing NASH, which is a type of NAFLD. This procedure is invasive, and many studies are currently looking for and assessing non-invasive markers for NAFLD and metabolic syndrome. Laboratory as diagnostic support plays an important role in the diagnosis of NAFLD and metabolic syndrome. Non-invasive laboratory tests with high sensitivity and specificity are expected to contribute to the early diagnosis of NAFLD and metabolic syndrome. Various laboratory parameters have been developed to support the diagnosis of NAFLD and metabolic syndrome.
{"title":"Non-Alcoholic Fatty Liver Disease and Metabolic Syndrome: Diagnostic and Laboratory Approach","authors":"Victoria Mayasari, Yessy Puspitasari","doi":"10.24293/ijcpml.v29i1.2029","DOIUrl":"https://doi.org/10.24293/ijcpml.v29i1.2029","url":null,"abstract":"Both Non-Alcoholic Fatty Liver Disease (NAFLD) and metabolic syndrome are health problems worldwide. Various studies suggest that NAFLD and metabolic syndrome have a two-way relationship. Metabolic syndrome can be preceded by NAFLD and NAFLD can be a manifestation of the metabolic syndrome. Because of the relationship between the two, the diagnosis and management of NAFLD and metabolic syndrome are important to prevent complications such as cardiovascular disease, liver cirrhosis, and malignancy. The diagnosis of metabolic syndrome can be made based on various diagnostic criteria determined by several health organizations, such as WHO, IDF, and NCEP-ATP. Since NAFLD is asymptomatic until advanced disease, many patients are only identified at advanced stages. Liver biopsy is currently the gold standard for diagnosing NASH, which is a type of NAFLD. This procedure is invasive, and many studies are currently looking for and assessing non-invasive markers for NAFLD and metabolic syndrome. Laboratory as diagnostic support plays an important role in the diagnosis of NAFLD and metabolic syndrome. Non-invasive laboratory tests with high sensitivity and specificity are expected to contribute to the early diagnosis of NAFLD and metabolic syndrome. Various laboratory parameters have been developed to support the diagnosis of NAFLD and metabolic syndrome.","PeriodicalId":354500,"journal":{"name":"Indonesian Journal of Clinical Pathology and Medical Laboratory","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121245400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-19DOI: 10.24293/ijcpml.v29i1.1964
Natra Dias Surohadi, D. Retnoningrum, M. Hendrianingtyas, E. Noer, A. Syauqi
Obesity is an excessive fat accumulation due to an imbalance between energy intake and consumption. Central obesity, represented by an increase in Waist Circumference (WC) and waist-to-hip ratio, is a predictor for obesity-related metabolic disorders and has replaced BMI to determine the clinical diagnosis of metabolic syndrome. Lipid accumulation product calculated from WC and fasting triglyceride concentration is presumed to be an alternative to measure excessive lipid accumulation and a marker to predict diabetes or cardiovascular risk. Lipid accumulation product is related to cardiovascular disease, diabetes, and metabolic syndrome and is preferable to BMI to identify diseases. It has been established that obesity and increased visceral adipocytes contribute to increased levels of some inflammatory proteins such as CRP. This study aimed to determine the correlation between LAP with FBG and CRP in obese females. This cross-sectional study involved female with obesity aged 35-50 years at Diponegoro National Hospital, Semarang, carried out from February to May 2021. Lipid accumulation product was calculated using LAP=(WC[cm]–58)×(TG[mmol/L]), TG and FBG levels were measured with the colorimetric enzymatic method, and CRP levels were analyzed with an immunoturbidimetric method using the chemical analyzer. The correlation between variables was analyzed using Pearson and Spearman correlation tests (p <0.05). CRP and FBG average levels were 3.546±2.6554 mg/dL and 83.1±11.363 mg/dL, respectively. There was a weak positive correlation between LAP with FBG (p=0.033; r=0.262) and LAP with CRP (p=0.04; r=0.251). Therefore, lipid accumulation products might influence FBG and CRP levels in the obese population
{"title":"Correlation between Lipid Accumulation Product with Fasting Blood Glucose and CRP in Obese Females","authors":"Natra Dias Surohadi, D. Retnoningrum, M. Hendrianingtyas, E. Noer, A. Syauqi","doi":"10.24293/ijcpml.v29i1.1964","DOIUrl":"https://doi.org/10.24293/ijcpml.v29i1.1964","url":null,"abstract":"Obesity is an excessive fat accumulation due to an imbalance between energy intake and consumption. Central obesity, represented by an increase in Waist Circumference (WC) and waist-to-hip ratio, is a predictor for obesity-related metabolic disorders and has replaced BMI to determine the clinical diagnosis of metabolic syndrome. Lipid accumulation product calculated from WC and fasting triglyceride concentration is presumed to be an alternative to measure excessive lipid accumulation and a marker to predict diabetes or cardiovascular risk. Lipid accumulation product is related to cardiovascular disease, diabetes, and metabolic syndrome and is preferable to BMI to identify diseases. It has been established that obesity and increased visceral adipocytes contribute to increased levels of some inflammatory proteins such as CRP. This study aimed to determine the correlation between LAP with FBG and CRP in obese females. This cross-sectional study involved female with obesity aged 35-50 years at Diponegoro National Hospital, Semarang, carried out from February to May 2021. Lipid accumulation product was calculated using LAP=(WC[cm]–58)×(TG[mmol/L]), TG and FBG levels were measured with the colorimetric enzymatic method, and CRP levels were analyzed with an immunoturbidimetric method using the chemical analyzer. The correlation between variables was analyzed using Pearson and Spearman correlation tests (p <0.05). CRP and FBG average levels were 3.546±2.6554 mg/dL and 83.1±11.363 mg/dL, respectively. There was a weak positive correlation between LAP with FBG (p=0.033; r=0.262) and LAP with CRP (p=0.04; r=0.251). Therefore, lipid accumulation products might influence FBG and CRP levels in the obese population","PeriodicalId":354500,"journal":{"name":"Indonesian Journal of Clinical Pathology and Medical Laboratory","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123100323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
SARS-CoV-2 binds to ACE2 receptors and causes endothelial injury. Endothelial injury causes the release of tissue factors and triggers the activation of the coagulation cascade, which is characterized by an increase in D-dimer levels. The increase in D-dimer levels reflects the activation of coagulation and fibrinolysis. Endothelial injury leads to platelet adhesion and aggregation. Mean platelet volume is a low-cost, routinely performed parameter available in hematology analyzers at various health facilities. This study aimed to determine the correlation between MPV and D-dimer in COVID-19 patients. This study was an analytical study with a cross-sectional design conducted on 88 subjects aged 18-50 years from COVID-19 patients who were admitted at Dr. M. Djamil Central Hospital in May-September 2021. Mean platelet volume levels were measured using the impedance method and D-dimer levels using the ELISA method. Data were analyzed using the Pearson correlation test, significant if p<0.05. The mean age was 33.47 years, range of 18-50 years. Most of the subjects were female, 53 people (62.4%). The mean MPV level was 10.36 (0.87) fL. The mean D-dimer levels were 728.51 (500.99) ng/mL. Correlation analysis showed that mean platelet volume had a weak positive correlation with D-dimer (r=0.269, p=0.013). This study showed an increase in MPV and D-dimer levels in COVID-19 patients. There is a weak correlation between MPV and D-dimer in COVID-19 patients.
{"title":"Correlation of Mean Platelet Volume with D-dimer in Patients with COVID-2019","authors":"Agri Febria Sari, Rikarni Rikarni, Desywar Desywar","doi":"10.24293/ijcpml.v29i1.2030","DOIUrl":"https://doi.org/10.24293/ijcpml.v29i1.2030","url":null,"abstract":"SARS-CoV-2 binds to ACE2 receptors and causes endothelial injury. Endothelial injury causes the release of tissue factors and triggers the activation of the coagulation cascade, which is characterized by an increase in D-dimer levels. The increase in D-dimer levels reflects the activation of coagulation and fibrinolysis. Endothelial injury leads to platelet adhesion and aggregation. Mean platelet volume is a low-cost, routinely performed parameter available in hematology analyzers at various health facilities. This study aimed to determine the correlation between MPV and D-dimer in COVID-19 patients. This study was an analytical study with a cross-sectional design conducted on 88 subjects aged 18-50 years from COVID-19 patients who were admitted at Dr. M. Djamil Central Hospital in May-September 2021. Mean platelet volume levels were measured using the impedance method and D-dimer levels using the ELISA method. Data were analyzed using the Pearson correlation test, significant if p<0.05. The mean age was 33.47 years, range of 18-50 years. Most of the subjects were female, 53 people (62.4%). The mean MPV level was 10.36 (0.87) fL. The mean D-dimer levels were 728.51 (500.99) ng/mL. Correlation analysis showed that mean platelet volume had a weak positive correlation with D-dimer (r=0.269, p=0.013). This study showed an increase in MPV and D-dimer levels in COVID-19 patients. There is a weak correlation between MPV and D-dimer in COVID-19 patients.","PeriodicalId":354500,"journal":{"name":"Indonesian Journal of Clinical Pathology and Medical Laboratory","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125879512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-19DOI: 10.24293/ijcpml.v29i1.1917
Rama Dhanivita Djamin, Z. Rofinda, Desywar Desywar
Sepsis is a clinical condition of potentially life-threatening organ dysfunction caused by the host's response to infection. Delayed diagnosis and treatment of sepsis lead to worsening of the disease, which can lead to circulatory collapse, multiple organ failure, and death, therefore accurate and timely diagnosis can prevent death. Procalcitonin (PCT) is the most widely used, studied, and promising marker for the diagnosis of sepsis. Recent studies have shown that procalcitonin plays an important role in the clinical diagnosis of sepsis because it can differentiate sepsis from SIRS. Most studies found an increase in the Mean Platelet Volume (MPV) in septic patients, both neonates, and adults. The MPV value can be used as a parameter to assess the prognosis of septic patients. This cross-sectional analytical study was conducted on 21 septic patients at Dr. M. Djamil Hospital, Padang from January 2020 to April 2021. Mean platelet volume values were determined using an automatic hematology analyzer based on the formula made by the device. Procalcitonin levels were measured using the enzym-linked immunofluorescent assay method. Data were analyzed by Pearson correlation test and p < 0.05 was significant. The mean age of the research subjects was 54 years and the range was 22-77 years. The number of male and female research subjects in this study was almost the same, consisting of 10 male (48%) and 11 female (52%) patients. The average MPV was 10.59(0.56) fL and the median procalcitonin was 9.35(2.08-200) ng/mL. Pearson correlation test showed that MPV was positively correlated with procalcitonin with moderate correlation (r=0.435, p=0.049). There was a moderate positive correlation between MPV and procalcitonin in septic patients.
{"title":"Correlation between Mean Platelet Volume and Procalcitonin in Sepsis Patients","authors":"Rama Dhanivita Djamin, Z. Rofinda, Desywar Desywar","doi":"10.24293/ijcpml.v29i1.1917","DOIUrl":"https://doi.org/10.24293/ijcpml.v29i1.1917","url":null,"abstract":"Sepsis is a clinical condition of potentially life-threatening organ dysfunction caused by the host's response to infection. Delayed diagnosis and treatment of sepsis lead to worsening of the disease, which can lead to circulatory collapse, multiple organ failure, and death, therefore accurate and timely diagnosis can prevent death. Procalcitonin (PCT) is the most widely used, studied, and promising marker for the diagnosis of sepsis. Recent studies have shown that procalcitonin plays an important role in the clinical diagnosis of sepsis because it can differentiate sepsis from SIRS. Most studies found an increase in the Mean Platelet Volume (MPV) in septic patients, both neonates, and adults. The MPV value can be used as a parameter to assess the prognosis of septic patients. This cross-sectional analytical study was conducted on 21 septic patients at Dr. M. Djamil Hospital, Padang from January 2020 to April 2021. Mean platelet volume values were determined using an automatic hematology analyzer based on the formula made by the device. Procalcitonin levels were measured using the enzym-linked immunofluorescent assay method. Data were analyzed by Pearson correlation test and p < 0.05 was significant. The mean age of the research subjects was 54 years and the range was 22-77 years. The number of male and female research subjects in this study was almost the same, consisting of 10 male (48%) and 11 female (52%) patients. The average MPV was 10.59(0.56) fL and the median procalcitonin was 9.35(2.08-200) ng/mL. Pearson correlation test showed that MPV was positively correlated with procalcitonin with moderate correlation (r=0.435, p=0.049). There was a moderate positive correlation between MPV and procalcitonin in septic patients.","PeriodicalId":354500,"journal":{"name":"Indonesian Journal of Clinical Pathology and Medical Laboratory","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130171575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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