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During evolution, mutations occur randomly and are fixed by selection. At the same time, species gradually formed, producing various life forms. In the traditional evolutionary theory system, mutations are considered genetic mutations by default, and somatic mutations are usually applicable in specific scenarios such as carcinogenesis, immunity and aging. At the same time, selection plays a role at multiple levels of living systems, including genes, cells, tissues and organs, individuals, populations, species, and even ecosystems. The research community of modern life science expresses genetic mutations as genotypes and cellular and other level characteristics as phenotypes, and finds that phenotypes are determined by both genotypes and environmental factors. Currently, it is unclear how genotypic and environmental factors act at the cellular level to create and fix new cell types. In this review, we summarize that it's time to move forward from gene evolution to build the framework for cell type evolution and finally update the theoretical system for evolutionary biology.

Tumor itself is a complex microecosystem, with complex spatio-temporal dynamics and multi-dimensional interactions. Its unimaginable heterogeneity and evolvability have exceeded the cognition of traditional oncology medicine. How to systematically characterize the whole tumor cell ecosystem from the dynamics and interaction of material, energy and signal levels, in order to explore new cognition, new rules and new therapies for the occurrence and development of tumors, is a new proposition and goal of tumor ecology. In this review, we discuss the origin, occurrence and development of tumors from the perspective of evolutionary ecology. First, we discuss the application of some classical concepts of ecology with tumor evolution. Subsequently, through the integration of the frontier papers of tumor ecology, we highlight the importance of ecological interactions on the occurrence and development of tumors from multiple levels, such as between cancer cells, between cancer cells and other normal somatic cells, and the tumor ecosystem. Finally, we propose the concept of tumor cell ecosystem, discussed how to characterize the entire tumor ecosystem from the system theory and proposed possible innovative treatment directions.

Echolocation is a complex biological traits that collaborated by multiple systems. Its origin can be traced back to 68 million years ago, and repeatedly appeared in multiple vertebrate groups in the subsequent biological evolution. The strong vitality has become a typical case of the convergence evolution in nature. However, it was not until the beginning of the 20th century that humans really opened the prelude to the research on animal echolocation, and became research hotspots in the fields of zoology, behavior, and genetics, and achieved rich results in the past 80 years. In this review, we summarize the development history of animal echo positioning, summarize different echo positioning animal groups in detail, and focuse on the research progress of echo positioning in sound mechanisms, acoustic characteristics, and high-frequency listening mechanisms in order to provide reference for comprehensive understanding of animal echo positioning.

The origin and evolution of sex chromosomes have long been a focus of research in biology. Two of the most studied systems are the XY system and the ZW system. Due to Y/W degeneration, heterozygous (XY/ZW) sex-linked genes are absent and their dosage is reduced when compared to autosomal genes and homozygous (XX/ZZ) sex-linked genes, creating an issue of dosage imbalance between sex chromosomes and autosomes. Multiple evolutionary models have been proposed to explain the evolutionary mechanism of dosage compensation that might resolve such dosage imbalance. In this review, we summarize the findings related to the dosage effect of sex chromosomes from a variety of perspectives, including transcriptomes, proteomes, haploid cells, and single cells. In addition, a summary of the dosage effect of sex chromosomes in major phylogenetic branches of multiple species is provided. Finally, we approved an overview of the related theoretical models and future research directions at the end of this paper.

Evolutionary developmental biology combines evolutionary biology and developmental biology, focusing on the evolution of developmental processes and the mechanisms of morphological diversification. Since the discovery of the homeobox gene in 1984, the genetic mechanisms of morphogenesis in multiple model organisms have been systematically studied. In contrast, non-model organisms are rich in complex evolutionary traits, yet their underlying genetic mechanisms have not yet been fully elucidated, so more relevant studies are still needed. Among non-model organisms, butterflies are rich in species diversity, with more than 18,700 species. In particular, butterfly wings have simple flat structures but exhibit diverse and complex patterns, likely associated with complex functions(e.g., defense and courtship) and subject to strong selective pressures, which makes them a classic system for evolutionary developmental biology studies. Early comparative morphological studies proposed the Nymphalid ground plan, providing a theoretical framework for the evolutionary developmental biology of butterfly wing patterns; a series of interference experiments on butterfly wing discs later confirmed the association between the wing developmental process and phenotypes. In recent years, by integrating genetics, developmental biology, and genomics research methods, genetic toolkit genes and loci involved in wing pattern regulation have been identified in several butterfly species, further improving the theoretical framework for studying butterfly wing pattern evolution and development. From the methodological perspective, experimental methods such as in situ hybridization and gene editing have played an important role in evolutionary developmental biology studies of butterfly wings, and the development of hybridization chain reaction technology and CRISPR/Cas9 gene editing technology has further advanced the feasibility of functional validation in butterflies. In the future, the development and optimization of lepidopteran RNA interference and gene editing technologies can promote functional studies, thus expanding the research systems of evolutionary developmental biology by comparing and analyzing complex traits. The above research can also be broadened to an ecological-evolutionary-developmental context to explore genetic and environmental factors that shape complex phenotypes(e.g., butterfly wing patterns), thereby deepening the understanding of key scientific issues such as the origin and evolution of biodiversity.

Since Darwin's era, speciation has been one of the most central issues in evolutionary biology studies. Understanding the processes of species origin is crucial in deepening our understanding of the formation of species biodiversity, which is essential for their protections. However, speciation research has been challenging due to the rather complex evolutionary histories of many extant species. In recent years, with the continuous advancements in genomic sequencing techniques, significant advances have been achieved in the field of speciation researches. In this review, we overview speciation study advances, especially in the concepts and latest developments in research methods for studying speciation in the genomic era, encompassing the major research aspects: species delimitation, bifurcating speciation, hybrid speciation, polyploid speciation, reproductive isolation genes and speciation genes. Furthermore, we discuss the limitations of these studies and methods. Finally, we provide the outlook on the future challenges and directions in speciation researches.

The northern part of Asia, including Siberia, the Mongolian Plateau, and northern China, is not only a crossroads for population exchange on the Eurasian continent but also an important bridge connecting the American continent. This region holds a unique and irreplaceable significance in exploring the origins of humanity, tracking human migration routes, and elucidating evolutionary mechanisms. Despite the limited number of samples unearthed, varying preservation conditions, and constraints of technical means, our understanding of the interactions among populations in northern Asia is still in its infancy. However, the development of high-throughput sequencing technology and its advancement in ancient DNA research have provided us with a new perspective for delving into the genetic history of ancient populations from a molecular level. In this review, we synthesize the changes in the genetic structure of ancient populations in different stages of northern Asia, aiming to reveal the patterns of interaction among ancient populations in this region, the evolutionary process of their genetic structure, and their genetic contributions to modern populations. It will also discuss the adaptive strategies of humans in response to extreme natural conditions. This will not only deepen our understanding of the origins and migration processes of humanity but also provide a solid foundation for studying the evolutionary mechanisms and adaptive strategies of humans under environmental selective pressures.

Speciation research represents our thinking and exploration about how new species are generated and maintained, and it is one of the most important parts of evolutionary biology. Revealing new species formation modes, processes of reproductive isolation establishment and their intrinsic genetic mechanisms, are not only important issues and primary tasks in the field of speciation, but also the key clues for our understandings about the species diversity in nature. Here, by focusing on animal groups, we first introduced different definitions of species concept, and then summarized present research progress and important breakthroughs made in the speciation modes and molecular mechanism of reproductive isolation. We also pointed out some limitations in current studies. Finally, we discuss the potential opportunities and new breakthroughs that can be made in the future studies of animal speciation.

Over the past decade, the continuous development of ancient genomic technology and research has significantly advanced our understanding of human history. Since 2017, large-scale studies of ancient human genomes in East Asia, particularly in China, have emerged, resulting in a wealth of ancient genomic data from various time periods and locations, which has provided new insights into the genetic history of East Asian populations over tens of thousands of years. Especially since 2022, there emerged a series of new research progresses in the genetic histories of the northern and southern Chinese populations within the past 10,000 years. However, there is currently no systematic review focused on these recent ancient genomic studies in East Asia. Therefore, this article emphasizes the study of ancient human genomes in China and systematically reviews the genetic patterns and migration history of populations in East Asia since the Late Paleolithic. Existing research indicates that by at least 19,000 years ago, there was a north-south differentiation among ancient East Asian populations, leading to different genetic lineages divided by the Qinling-Huaihe line. Gene flow and interactions between northern and southern East Asians began in the Early Neolithic and were further strengthened from the Mid-Neolithic. By the historical period, northern East Asian ancestry played a profound role in the genetic components of southern populations, shaping the genetic structure of present-day Chinese populations. Throughout this process, ancient populations in northern and southern China also engaged in extensive interactions through coastal and inland routes with populations from surrounding regions, including Siberia, Japan, Korea, Southeast Asia, and Pacific islands, playing a crucial role in the formation of different linguistic groups. These studies have charted the evolutionary and interaction history of East Asian populations over tens of thousands of years; yet, many unresolved mysteries remain. Further exploration is needed through ancient genomic data from additional time periods and broader geographic areas to facilitate a more comprehensive and detailed investigation, thereby advancing related scientific questions.