Kohei Tanaka, Shouhei Katayama, K. Okura, Masatsugu Okamura, K. Nawata, N. Nakanishi, A. Shinohara
{"title":"Skeletal muscle mass assessment in critically ill patients: method and application","authors":"Kohei Tanaka, Shouhei Katayama, K. Okura, Masatsugu Okamura, K. Nawata, N. Nakanishi, A. Shinohara","doi":"10.4993/acrt.30.93","DOIUrl":"https://doi.org/10.4993/acrt.30.93","url":null,"abstract":"","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44461315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hidetaka Kawamura, T. Miyakawa, Y. Tsujimoto, R. Yamamoto, Norio Watanabe, M. Honda
{"title":"The clinical effect of total mesorectal excision with lateral lymph node dissection for lower rectal cancer: A systematic review and meta-analysis","authors":"Hidetaka Kawamura, T. Miyakawa, Y. Tsujimoto, R. Yamamoto, Norio Watanabe, M. Honda","doi":"10.4993/acrt.30.106","DOIUrl":"https://doi.org/10.4993/acrt.30.106","url":null,"abstract":"","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47338167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jeevitaa R. Kshersagar, Mrunal N. Damle, Poonam A. Bedge, Rakhi V. Jagdale, Kishor R. Tardalkar, Swapnali Jagadale, D. Jadhav, Yashwant Toro, M. Joshi
{"title":"Soluble MICA in Biofluids as Biomarker in Tracing Oral Malignant Growth Which Relates with Disease Stage","authors":"Jeevitaa R. Kshersagar, Mrunal N. Damle, Poonam A. Bedge, Rakhi V. Jagdale, Kishor R. Tardalkar, Swapnali Jagadale, D. Jadhav, Yashwant Toro, M. Joshi","doi":"10.4993/acrt.30.131","DOIUrl":"https://doi.org/10.4993/acrt.30.131","url":null,"abstract":"","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42621256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yoko Touyama, K. Hirano, Einosuke Ono, Y. Abe, Tatsuya Shirai, A. Mouri, Atsushi Sakakibara, M. Ohno, Toshiya Inui, K. Suhara, M. Kamimura
{"title":"Primary malignant pericardial mesothelioma in a patient with a history of thoracic radiotherapy and asbestos exposure: A case report","authors":"Yoko Touyama, K. Hirano, Einosuke Ono, Y. Abe, Tatsuya Shirai, A. Mouri, Atsushi Sakakibara, M. Ohno, Toshiya Inui, K. Suhara, M. Kamimura","doi":"10.4993/acrt.30.18","DOIUrl":"https://doi.org/10.4993/acrt.30.18","url":null,"abstract":"","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45890491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Leucopenia induced by tamoxifen in a breast cancer patient: a case report","authors":"Y. Al-Bairmany","doi":"10.4993/acrt.30.8","DOIUrl":"https://doi.org/10.4993/acrt.30.8","url":null,"abstract":"","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":"72 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41330890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Honda, Muhammad Wannous, Kazumichi Yamamoto, Akiko Yoshida
{"title":"A feasibility study for smartphone application to evaluate dietary realities after gastrointestinal surgery","authors":"M. Honda, Muhammad Wannous, Kazumichi Yamamoto, Akiko Yoshida","doi":"10.4993/acrt.30.33","DOIUrl":"https://doi.org/10.4993/acrt.30.33","url":null,"abstract":"","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42055214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hind Mimouni, K. Hassouni, Boujemaa EL Marnissi, Bouchra Haddou Rahou, L. Alaoui, R. Ismaili, A. Hilali, A. Nejmeddine, R. Bekkali, Leila Loukili
{"title":"The patient, diagnosis and treatment delay of the care pathway of patients with breast Cancer in Morocco","authors":"Hind Mimouni, K. Hassouni, Boujemaa EL Marnissi, Bouchra Haddou Rahou, L. Alaoui, R. Ismaili, A. Hilali, A. Nejmeddine, R. Bekkali, Leila Loukili","doi":"10.4993/acrt.30.11","DOIUrl":"https://doi.org/10.4993/acrt.30.11","url":null,"abstract":"","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44825749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chaimae Hafidi Alaoui, H. El ahanidi, M. El Azzouzi, A. Filali-Maltouf, I. Chaoui, M. Bensaid, L. Benbacer, Mohammed Tetou, Ilias Hassan, M. Oukabli, A. Ameur, A. Al bouzidi, Mohammed Attaleb, M. El Mzibri
Background: Human telomerase reverse transcriptase (hTERT) promoter mutations are common genetic events in blad- der cancer (BC) and have been recognized as potential biomarkers for BC diagnosis and prognosis. Detection of TERT promoter mutations as urine-based tests has previously been reported to detect primary and recurrent BC. This study was planned to evaluate hTERT promoter mutations in both biopsies and urines from BC patients to assess the interest and the usefulness of introducing these biomarkers for better management of BC in Morocco. Methods: In a cohort study involving a series of BC 70 patients with different stages and grades, hTERT promoter mutations were identified in both fresh biopsies and urine sediments by PCR amplification and DNA sequencing. Results: Overall, hTERT promoter mutations were reported in 60% of cancer biopsies (42/70), the hotspot mutations C228T and C250T were respectively identified in 80.95% (34/42) and 16.67% (7/42) of positive cases. Other mutations: A161C and G149T were also reported and were obtained in 2.38% (1/42) and 2.38% (1/42), respectively. hTERT promoter mutations were identified in 30% of matched urine sediments (21/70) and showed an overall sensitivity of 50% and specificity of 100%. In patients with non-muscle invasive bladder cancer, no statistically significant association was detected between TERT promoter mutations and recurrence-free survival (HR: 1.224, 95% CI: 0.373–4.011, p = 0.739), and overall survival (HR: 0.363, 95% CI: 0.041–3.244, p = 0.364). Conclusion: hTERT promoter mutations are early events occurring with high frequencies and can be identified in the exfo- liated cells, making them an interesting non-invasive biomarker for diagnosis and follow-up of bladder cancer.
人类端粒酶逆转录酶(hTERT)启动子突变是膀胱癌(BC)中常见的遗传事件，已被认为是膀胱癌诊断和预后的潜在生物标志物。检测TERT启动子突变作为基于尿液的测试，以前曾报道过检测原发性和复发性BC。本研究计划评估BC患者活检和尿液中的hTERT启动子突变，以评估在摩洛哥引入这些生物标志物以更好地管理BC的兴趣和有用性。方法:在一项涉及一系列不同分期和分级的BC 70患者的队列研究中，通过PCR扩增和DNA测序在新鲜活检和尿液沉积物中发现hTERT启动子突变。结果:总体而言，60%的肿瘤活检报告了hTERT启动子突变(42/70)，阳性病例中分别有80.95%(34/42)和16.67%(7/42)发现了热点突变C228T和C250T。其他突变:A161C和G149T也有报道，分别为2.38%(1/42)和2.38%(1/42)。hTERT启动子突变在30%(21/70)的匹配尿液沉积物中被鉴定出来，总体敏感性为50%，特异性为100%。在非肌性浸润性膀胱癌患者中，TERT启动子突变与无复发生存率(HR: 1.224, 95% CI: 0.373 ~ 4.011, p = 0.739)和总生存率(HR: 0.363, 95% CI: 0.041 ~ 3.244, p = 0.364)无统计学意义相关。结论:hTERT启动子突变是发生频率高的早期事件，可在膀胱癌外移细胞中被识别，是膀胱癌诊断和随访的一种有趣的非侵入性生物标志物。
{"title":"Evaluation of TERT promoter mutations in tumor biopsies and urine sediment of Moroccan bladder cancer patients","authors":"Chaimae Hafidi Alaoui, H. El ahanidi, M. El Azzouzi, A. Filali-Maltouf, I. Chaoui, M. Bensaid, L. Benbacer, Mohammed Tetou, Ilias Hassan, M. Oukabli, A. Ameur, A. Al bouzidi, Mohammed Attaleb, M. El Mzibri","doi":"10.4993/acrt.30.1","DOIUrl":"https://doi.org/10.4993/acrt.30.1","url":null,"abstract":"Background: Human telomerase reverse transcriptase (hTERT) promoter mutations are common genetic events in blad- der cancer (BC) and have been recognized as potential biomarkers for BC diagnosis and prognosis. Detection of TERT promoter mutations as urine-based tests has previously been reported to detect primary and recurrent BC. This study was planned to evaluate hTERT promoter mutations in both biopsies and urines from BC patients to assess the interest and the usefulness of introducing these biomarkers for better management of BC in Morocco. Methods: In a cohort study involving a series of BC 70 patients with different stages and grades, hTERT promoter mutations were identified in both fresh biopsies and urine sediments by PCR amplification and DNA sequencing. Results: Overall, hTERT promoter mutations were reported in 60% of cancer biopsies (42/70), the hotspot mutations C228T and C250T were respectively identified in 80.95% (34/42) and 16.67% (7/42) of positive cases. Other mutations: A161C and G149T were also reported and were obtained in 2.38% (1/42) and 2.38% (1/42), respectively. hTERT promoter mutations were identified in 30% of matched urine sediments (21/70) and showed an overall sensitivity of 50% and specificity of 100%. In patients with non-muscle invasive bladder cancer, no statistically significant association was detected between TERT promoter mutations and recurrence-free survival (HR: 1.224, 95% CI: 0.373–4.011, p = 0.739), and overall survival (HR: 0.363, 95% CI: 0.041–3.244, p = 0.364). Conclusion: hTERT promoter mutations are early events occurring with high frequencies and can be identified in the exfo- liated cells, making them an interesting non-invasive biomarker for diagnosis and follow-up of bladder cancer.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47047384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yukiko Nonaka, T. Seki, Satomi Saeki, N. Uemura, T. Ito, Masahiro Tanaka, Koki Tabata, Hiromasa Yamashita, T. Arai, Takeshi Amemiya
{"title":"Long-term outcome of omentectomy for patients with pT3 gastric cancer","authors":"Yukiko Nonaka, T. Seki, Satomi Saeki, N. Uemura, T. Ito, Masahiro Tanaka, Koki Tabata, Hiromasa Yamashita, T. Arai, Takeshi Amemiya","doi":"10.4993/acrt.30.45","DOIUrl":"https://doi.org/10.4993/acrt.30.45","url":null,"abstract":"","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45410348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cuong Nguyen Pham, Thanh Hai Phan, X. Nguyễn, Hoang Thanh Cao, Hien Nhu Pham, Anh Hoai Vu
{"title":"Primary hepatic neuroendocrine carcinoma: A postoperative diagnosis","authors":"Cuong Nguyen Pham, Thanh Hai Phan, X. Nguyễn, Hoang Thanh Cao, Hien Nhu Pham, Anh Hoai Vu","doi":"10.4993/acrt.30.28","DOIUrl":"https://doi.org/10.4993/acrt.30.28","url":null,"abstract":"","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43404741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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