T. N. Tran, Nguyen Tuong Pham, Doan Thi, H. S. Nguyen
Objective: The survey aims to explore the quality of life and its contributing factors among breast cancer patients who had been treated at the hospital and returned for follow-up care and/or for taking hormonal therapy. Methods: This cross-sectional study deployed questionnaire-based interviews with 115 patients when they came to the hospital for follow-up care and/or taking hormonal therapy at the Oncology Center of Hue Central Hospital (Vietnam) from April to May 2019. Collected data were analyzed using SPSS software 21 for Windows. Results: The mean age of our study was 53.2 years. Among the total respondents, 88.7% of patients had hormone receptorpositive breast cancer. Most respondents reported experiencing symptoms that decreased their health-related quality of life, such as dry mouth, appetite changes, fatigue, arm pain, and limited mobility in ipsilateral arm. The majority felt insecure because of their asymmetric and less good-looking post-mastectomy body image. Most of them were no longer interested in sexual activities. A large number of respondents turned to complementary therapies at home, which often incurred considerable costs. Conclusion: This survey contributes to the understanding of patients’ suffering symptoms, their concerns and anxiety, and distress during outpatient care/ clinic. It also provides baseline information on their thoughts and preferences for complementary therapies. Altogether the study carries important implications for clinicians to plan more effective treatment and care for breast cancer patients.
{"title":"Quality of Life and Its Contributing Factors among Breast Cancer Patients after Intensive Treatment","authors":"T. N. Tran, Nguyen Tuong Pham, Doan Thi, H. S. Nguyen","doi":"10.4993/acrt.28.102","DOIUrl":"https://doi.org/10.4993/acrt.28.102","url":null,"abstract":"Objective: The survey aims to explore the quality of life and its contributing factors among breast cancer patients who had been treated at the hospital and returned for follow-up care and/or for taking hormonal therapy. Methods: This cross-sectional study deployed questionnaire-based interviews with 115 patients when they came to the hospital for follow-up care and/or taking hormonal therapy at the Oncology Center of Hue Central Hospital (Vietnam) from April to May 2019. Collected data were analyzed using SPSS software 21 for Windows. Results: The mean age of our study was 53.2 years. Among the total respondents, 88.7% of patients had hormone receptorpositive breast cancer. Most respondents reported experiencing symptoms that decreased their health-related quality of life, such as dry mouth, appetite changes, fatigue, arm pain, and limited mobility in ipsilateral arm. The majority felt insecure because of their asymmetric and less good-looking post-mastectomy body image. Most of them were no longer interested in sexual activities. A large number of respondents turned to complementary therapies at home, which often incurred considerable costs. Conclusion: This survey contributes to the understanding of patients’ suffering symptoms, their concerns and anxiety, and distress during outpatient care/ clinic. It also provides baseline information on their thoughts and preferences for complementary therapies. Altogether the study carries important implications for clinicians to plan more effective treatment and care for breast cancer patients.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45709803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Yunusova, T. Aoyama, Matlyuba Khalmatova, Dilorom Djakhangirova, Shakhnoza Ortikbaeva, S. Mamarajabov, J. Sakamoto, Niginа Abduxalik-Zade
Background: The present study attempted to improve the multimodal diagnosis of complicated neck cysts. Materials and methods: 121 patients diagnosed to have neck cysts were entered in this study. The studies were performed on SLE-501 devices (Lithuania), Affiniti-70 (Philips, Holland) with linear sensors at a frequency of 7.5 and 12 MHz. Spiral CT was performed on a Somatom Emotion 6 apparatus (Siemens, Germany) using standard axial sections. Results: Significant differences between the groups with complicated cysts of the neck were found with regard to the size, homogeneity, and extracapsular spread. Local infiltration was found to have a greater long axis (p < 0.001), short axis (p < 0.001), and height (p < 0.001). They were less likely to have extracapsular spread (p = 0.044) or septations (p = 0.059) and more likely to be homogeneous (p < 0.001). Conclusion: The use of modern methods of complementary capabilities of computed tomography and magnetic resonance imaging in our study allowed us to evaluate in detail all of the features of complicated cysts of the neck, which in turn helped determine the most appropriate treatment strategy in each case.
{"title":"METHODS OF THE TOMOGRAPHIC VISUALIZATION OF COMPLICATED CYSTS OF THE NECK","authors":"L. Yunusova, T. Aoyama, Matlyuba Khalmatova, Dilorom Djakhangirova, Shakhnoza Ortikbaeva, S. Mamarajabov, J. Sakamoto, Niginа Abduxalik-Zade","doi":"10.4993/acrt.28.152","DOIUrl":"https://doi.org/10.4993/acrt.28.152","url":null,"abstract":"Background: The present study attempted to improve the multimodal diagnosis of complicated neck cysts. Materials and methods: 121 patients diagnosed to have neck cysts were entered in this study. The studies were performed on SLE-501 devices (Lithuania), Affiniti-70 (Philips, Holland) with linear sensors at a frequency of 7.5 and 12 MHz. Spiral CT was performed on a Somatom Emotion 6 apparatus (Siemens, Germany) using standard axial sections. Results: Significant differences between the groups with complicated cysts of the neck were found with regard to the size, homogeneity, and extracapsular spread. Local infiltration was found to have a greater long axis (p < 0.001), short axis (p < 0.001), and height (p < 0.001). They were less likely to have extracapsular spread (p = 0.044) or septations (p = 0.059) and more likely to be homogeneous (p < 0.001). Conclusion: The use of modern methods of complementary capabilities of computed tomography and magnetic resonance imaging in our study allowed us to evaluate in detail all of the features of complicated cysts of the neck, which in turn helped determine the most appropriate treatment strategy in each case.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48826750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nguyen C Pham, T. Nguyen, Nguyen Tuong Pham, T. Phan, H. Phan
Aims: We carried out this research to investigate the pathological characteristics of NPC to broaden the knowledge in diagnosing and treating this type of cancer. Materials and Methods: This is a retrospective analysis of 106 patients diagnosed with nasopharyngeal carcinoma (NPC) at the Department of Pathology of Hue Central Hospital from January 2018 to June 2020. This study demonstrates the clinical data (age and sex) and histopathological findings of all patients. The histopathological diagnosis is based on the WHO classification in 1991. Results: The data of 73 male patients and 33 female patients were analyzed and showed that the proportion of undifferentiated carcinoma was the most common type (70.8%), followed by well-differentiated keratinizing squamous cell carcinoma (19.8%) and other types (9.4%). In terms of immunohistochemistry, 21/21 of well-differentiated keratinizing squamous cell carcinoma cases expressed positive reactivity to CKAE1/3; meanwhile, only 5/75 of undifferentiated cases had the same result. Discussion: Biopsy is essential for the identification of cancerous tissues. Therefore, the specimen should be obtained precisely and sufficiently in the area of injury. It is notable for avoiding collecting the necrosis areas and taking the edge of the lesion. We recommended a clinical consultation between otolaryngologists and oncologists to determine the area and the general characteristics of the lesion for making a more accurate diagnosis and prognosis. Immunohistochemistry can be helpful in confirming the type of nasopharyngeal carcinoma cases that are already stained with hematoxylin and eosin but are still challenging to diagnose.
{"title":"Pathological features of nasopharyngeal carcinoma: A single-center study in Vietnam","authors":"Nguyen C Pham, T. Nguyen, Nguyen Tuong Pham, T. Phan, H. Phan","doi":"10.4993/acrt.28.125","DOIUrl":"https://doi.org/10.4993/acrt.28.125","url":null,"abstract":"Aims: We carried out this research to investigate the pathological characteristics of NPC to broaden the knowledge in diagnosing and treating this type of cancer. Materials and Methods: This is a retrospective analysis of 106 patients diagnosed with nasopharyngeal carcinoma (NPC) at the Department of Pathology of Hue Central Hospital from January 2018 to June 2020. This study demonstrates the clinical data (age and sex) and histopathological findings of all patients. The histopathological diagnosis is based on the WHO classification in 1991. Results: The data of 73 male patients and 33 female patients were analyzed and showed that the proportion of undifferentiated carcinoma was the most common type (70.8%), followed by well-differentiated keratinizing squamous cell carcinoma (19.8%) and other types (9.4%). In terms of immunohistochemistry, 21/21 of well-differentiated keratinizing squamous cell carcinoma cases expressed positive reactivity to CKAE1/3; meanwhile, only 5/75 of undifferentiated cases had the same result. Discussion: Biopsy is essential for the identification of cancerous tissues. Therefore, the specimen should be obtained precisely and sufficiently in the area of injury. It is notable for avoiding collecting the necrosis areas and taking the edge of the lesion. We recommended a clinical consultation between otolaryngologists and oncologists to determine the area and the general characteristics of the lesion for making a more accurate diagnosis and prognosis. Immunohistochemistry can be helpful in confirming the type of nasopharyngeal carcinoma cases that are already stained with hematoxylin and eosin but are still challenging to diagnose.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44903050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manoj Gupta, Ganesan Karthikeyan, P. Choudhury, Anurag Sharma, S. Rawal
Aim: We analyzed the clinical outcome of Lutetium-177 Prostate-specific membrane antigen (Lu-177 PSMA) in metastatic castration-resistant prostate cancer (mCRPC) patients. Material and Methods: Twenty-five mCRPC patients were treated with Lu-177 PSMA on a compassionate basis. Pre and 8-10 weeks post-treatment PSA, Eastern cooperative oncology group (ECOG) performance status, Visual analog scale (VAS), and Analgesic quantification scale (AQS) were recorded. Based on PSA response (partial response PR, stable disease SD, progressive disease PD), patients were categorized into responder (PR+SD) and non-responder (PD). Wilcoxon signed-rank, and Kruskal–Wallis test, Kaplan Meier with Log-rank test were computed. Results: Twenty-five mCRPC patients were treated with a median of 7.4 GBq Lu-177 PSMA. Overall, PR, SD, and PD were 24%, 60%, and 16%, respectively. Sixteen patients who received ≥7.4 GBq Lu-177 PSMA dose, PR, and SD were seen in 31.2% and 68.8%, respectively. We had 84% responders and 16% non-responders. Statistically significant difference (P = < 0.05) was seen in pre and post ECOG, VAS, and AQS parameters while it was in-significant for PSA (P = 0.170). Lu-177 PSMA dose was the only significant pre-therapy variable (P = 0.024) on Kruskal–Wallis test. Overall median PFS was 24 weeks, while two years PFS in PR, SD, and PD response group was 50%, 37.3%, and 0%, respectively. A significant difference was seen in the PFS of responder and non-responder groups. Conclusions: We concluded that Lu-177 PSMA was a suitable palliative option in heavily pre-treated mCRPC patients with notable PSA response. However, proper randomized studies are warranted.
{"title":"Clinical outcome of Lu-177 PSMA in metastatic castration-resistant prostate cancer: An initial experience from a tertiary care cancer hospital","authors":"Manoj Gupta, Ganesan Karthikeyan, P. Choudhury, Anurag Sharma, S. Rawal","doi":"10.4993/acrt.28.156","DOIUrl":"https://doi.org/10.4993/acrt.28.156","url":null,"abstract":"Aim: We analyzed the clinical outcome of Lutetium-177 Prostate-specific membrane antigen (Lu-177 PSMA) in metastatic castration-resistant prostate cancer (mCRPC) patients. Material and Methods: Twenty-five mCRPC patients were treated with Lu-177 PSMA on a compassionate basis. Pre and 8-10 weeks post-treatment PSA, Eastern cooperative oncology group (ECOG) performance status, Visual analog scale (VAS), and Analgesic quantification scale (AQS) were recorded. Based on PSA response (partial response PR, stable disease SD, progressive disease PD), patients were categorized into responder (PR+SD) and non-responder (PD). Wilcoxon signed-rank, and Kruskal–Wallis test, Kaplan Meier with Log-rank test were computed. Results: Twenty-five mCRPC patients were treated with a median of 7.4 GBq Lu-177 PSMA. Overall, PR, SD, and PD were 24%, 60%, and 16%, respectively. Sixteen patients who received ≥7.4 GBq Lu-177 PSMA dose, PR, and SD were seen in 31.2% and 68.8%, respectively. We had 84% responders and 16% non-responders. Statistically significant difference (P = < 0.05) was seen in pre and post ECOG, VAS, and AQS parameters while it was in-significant for PSA (P = 0.170). Lu-177 PSMA dose was the only significant pre-therapy variable (P = 0.024) on Kruskal–Wallis test. Overall median PFS was 24 weeks, while two years PFS in PR, SD, and PD response group was 50%, 37.3%, and 0%, respectively. A significant difference was seen in the PFS of responder and non-responder groups. Conclusions: We concluded that Lu-177 PSMA was a suitable palliative option in heavily pre-treated mCRPC patients with notable PSA response. However, proper randomized studies are warranted.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47222628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yusupbekov A. Akhmedjanovich, M. Honda, Juraev E. Ergashbayevich, Usmanov B. Baymatovich, Mamarajabov S Ergashevich, Baymakov S. Risbaevich, Tuychiev O. Dilshod o’g’li, J. Sakamoto
Esophageal leiomyosarcoma (ELMS) is a rare tumor of mesenchymal origin that develops from the smooth muscles of the esophagus. ELMS is typically located in the lower third of the esophagus. We herein report a patient who underwent surgical resection for ELMS, 80 mm in diameter, in the upper third of the esophagus. A 58-year-old man experienced difficulty swallowing, and his swallowing function gradually deteriorated about 6 months before admission. McCeowns operation, which is a kind of esophagectomy performed via the thoraco-laparo-cervicotomy approach, was conducted. The postoperative course was good, without complications, and he was discharged on postoperative day 13. A pathological examination revealed highly differentiated ELMS.
{"title":"Giant leiomyosarcoma in the upper third of esophagus, a case report","authors":"Yusupbekov A. Akhmedjanovich, M. Honda, Juraev E. Ergashbayevich, Usmanov B. Baymatovich, Mamarajabov S Ergashevich, Baymakov S. Risbaevich, Tuychiev O. Dilshod o’g’li, J. Sakamoto","doi":"10.4993/acrt.28.49","DOIUrl":"https://doi.org/10.4993/acrt.28.49","url":null,"abstract":"Esophageal leiomyosarcoma (ELMS) is a rare tumor of mesenchymal origin that develops from the smooth muscles of the esophagus. ELMS is typically located in the lower third of the esophagus. We herein report a patient who underwent surgical resection for ELMS, 80 mm in diameter, in the upper third of the esophagus. A 58-year-old man experienced difficulty swallowing, and his swallowing function gradually deteriorated about 6 months before admission. McCeowns operation, which is a kind of esophagectomy performed via the thoraco-laparo-cervicotomy approach, was conducted. The postoperative course was good, without complications, and he was discharged on postoperative day 13. A pathological examination revealed highly differentiated ELMS.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43840778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Kono, Hideyuki Yokokawa, H. Shidei, Hiroyuki Maeda, Yuta Miyano, K. Oyama, T. Koike, S. Shiozawa, H. Oda, K. Yoshimatsu
We present a case of recto-sigmoidal cancer obtained pathological complete response as a result of laparoscopic surgery after chemotherapy concomitant use of panitumumab for the purpose of tumor shrinkage. A 64-year-old woman visited an emergency clinic complaining with continuous lower abdominal pain. She was diagnosed as a recto-sigmoidal cancer cT4b (right ureter and right ovary), N0, M0, cStage IIC. Preoperative chemotherapy was scheduled to expect tumor shrinkage. Based on the results of wild type gene concerning both RAS and BRAF, the modified 5-fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) plus panitumumab were administrated. After 4 cycles of treatment, since a down-stage to ycT3 was recognized, laproscopic high anterior resection with D3 lymphadenectomy was performed. She was judged in her primary lesion as a pathological complete response (pCR) by preoperative chemotherapy. Since her postoperative course was uneventful. No symptoms of relapse have been observed without adjuvant chemotherapy. A case of pCR after neoadjuvant treatment with mFOLFOX6 plus panitumumab followed by laparoscopic curative resection was reported. Further research is needed to confirm the appropriate indications for neoadjuvant therapy concomitant use of anti-EGFR antibody for patients with RAS wild typed locally advanced colon cancer.
{"title":"A case of cT4b recto-sigmoidal cancer obtained pathological complete response by preoperative chemotherapy with 4 cycles of mFOLFOX6 plus panitumumab","authors":"T. Kono, Hideyuki Yokokawa, H. Shidei, Hiroyuki Maeda, Yuta Miyano, K. Oyama, T. Koike, S. Shiozawa, H. Oda, K. Yoshimatsu","doi":"10.4993/acrt.28.133","DOIUrl":"https://doi.org/10.4993/acrt.28.133","url":null,"abstract":"We present a case of recto-sigmoidal cancer obtained pathological complete response as a result of laparoscopic surgery after chemotherapy concomitant use of panitumumab for the purpose of tumor shrinkage. A 64-year-old woman visited an emergency clinic complaining with continuous lower abdominal pain. She was diagnosed as a recto-sigmoidal cancer cT4b (right ureter and right ovary), N0, M0, cStage IIC. Preoperative chemotherapy was scheduled to expect tumor shrinkage. Based on the results of wild type gene concerning both RAS and BRAF, the modified 5-fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) plus panitumumab were administrated. After 4 cycles of treatment, since a down-stage to ycT3 was recognized, laproscopic high anterior resection with D3 lymphadenectomy was performed. She was judged in her primary lesion as a pathological complete response (pCR) by preoperative chemotherapy. Since her postoperative course was uneventful. No symptoms of relapse have been observed without adjuvant chemotherapy. A case of pCR after neoadjuvant treatment with mFOLFOX6 plus panitumumab followed by laparoscopic curative resection was reported. Further research is needed to confirm the appropriate indications for neoadjuvant therapy concomitant use of anti-EGFR antibody for patients with RAS wild typed locally advanced colon cancer.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41950337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Tamagawa, M. Numata, T. Aoyama, Ayako Tamagawa, K. Komori, Y. Maezawa, K. Kano, K. Kazama, M. Murakawa, Yosuke Atsumi, K. Hara, S. Kawahara, Takanobu Yamada, T. Ogata, T. Ohshima, N. Yukawa, M. Masuda, Y. Rino
Background: Minimally invasive esophagectomy theoretically has advantages over open esophagectomy. The purpose of the present study was to compare the short- and long-term outcomes of patients who underwent video-assisted thoracoscopic esophagectomy (VATE) or conventional open esophagectomy (OE) for esophageal carcinoma. Methods: A total of 122 patients who underwent radical esophagectomy via VATE (VATE group, N = 87) and OE (OE group, N = 35) for esophageal carcinoma between 2005 and 2018 were retrospectively enrolled in this study, and the postop- erative outcomes were compared. Results: The OE group had younger patients and more patients who received neo-adjuvant therapy that the VATE group. The procedure time in the OE group was also shorter than that in the VATE group (8.22 vs. 10.28 h, P < 0.001). Intraoperative blood loss was similar between the groups (P = 0.775). There were no significant differences in the total number of dissected lymph nodes between the groups (OE: 33, VATE: 37, P = 0.482). The incidence of severe complications was lower in the VATE group than in the OE group (44.8% vs. 65.7%, P = 0.037). With a median follow-up of 26 months, the 3-year overall survival and disease-free survival were similar between the two groups. Conclusion: VATE for esophageal carcinoma is associated with more favorable short-term outcomes and equal oncological outcomes compared with OE.
背景:微创食管切除术在理论上比开放式食管切除术有优势。本研究的目的是比较接受电视胸腔镜食管切除术(VATE)或传统开放式食管切除术(OE)治疗食管癌患者的短期和长期预后。方法:回顾性分析2005 - 2018年食管癌经VATE (VATE组，N = 87)和OE (OE组，N = 35)行根治性食管切除术的122例患者，比较其术后预后。结果:OE组患者较VATE组年轻，接受新辅助治疗的患者较多。OE组手术时间也短于VATE组(8.22 h vs. 10.28 h, P < 0.001)。两组术中出血量相近(P = 0.775)。两组间淋巴结清扫总数比较差异无统计学意义(OE: 33, VATE: 37, P = 0.482)。VATE组严重并发症发生率低于OE组(44.8% vs. 65.7%， P = 0.037)。中位随访26个月，两组的3年总生存期和无病生存期相似。结论:与OE相比，VATE治疗食管癌具有更有利的短期预后和相同的肿瘤预后。
{"title":"The Comparison of Outcomes between Video-assisted Thoracscopic and Open Surgery for Esophageal Cancer","authors":"H. Tamagawa, M. Numata, T. Aoyama, Ayako Tamagawa, K. Komori, Y. Maezawa, K. Kano, K. Kazama, M. Murakawa, Yosuke Atsumi, K. Hara, S. Kawahara, Takanobu Yamada, T. Ogata, T. Ohshima, N. Yukawa, M. Masuda, Y. Rino","doi":"10.4993/acrt.28.97","DOIUrl":"https://doi.org/10.4993/acrt.28.97","url":null,"abstract":"Background: Minimally invasive esophagectomy theoretically has advantages over open esophagectomy. The purpose of the present study was to compare the short- and long-term outcomes of patients who underwent video-assisted thoracoscopic esophagectomy (VATE) or conventional open esophagectomy (OE) for esophageal carcinoma. Methods: A total of 122 patients who underwent radical esophagectomy via VATE (VATE group, N = 87) and OE (OE group, N = 35) for esophageal carcinoma between 2005 and 2018 were retrospectively enrolled in this study, and the postop- erative outcomes were compared. Results: The OE group had younger patients and more patients who received neo-adjuvant therapy that the VATE group. The procedure time in the OE group was also shorter than that in the VATE group (8.22 vs. 10.28 h, P < 0.001). Intraoperative blood loss was similar between the groups (P = 0.775). There were no significant differences in the total number of dissected lymph nodes between the groups (OE: 33, VATE: 37, P = 0.482). The incidence of severe complications was lower in the VATE group than in the OE group (44.8% vs. 65.7%, P = 0.037). With a median follow-up of 26 months, the 3-year overall survival and disease-free survival were similar between the two groups. Conclusion: VATE for esophageal carcinoma is associated with more favorable short-term outcomes and equal oncological outcomes compared with OE.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43685954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yujiro Nakayama, Hidetaka Kawamura, Hiroshi Kobayashi, Yukitoshi Todate, R. Matsunaga, T. Miyakawa, M. Honda
Several tools to assess surgeons’ skills in laparoscopic surgeries have developed; nevertheless, the tools have not been developed to accommodate the Japanese guidelines and common surgical methods. Trainee surgeons would then not be able to learn the critical steps and important points of LCS procedures using the assessment tool. To fill the gap, we launched the “Development of an Assessment tool for Laparoscopic Colectomy” (ASLAC) project to develop a reliable tool to assess laparoscopic sigmoidectomy. The study consisted of two steps: cognitive task analysis (CTA) and application of the Delphi method. Consensus was defined in advance using Cronbach’s alpha ≥0.8. Items for which 70% of experts cited a value of ≥4 (agree or strongly agree) were used as novel tool. Ten expert surgeons (considered “qualified surgeons” by the Endoscopic Surgical Skill Qualification System in Japan) were recruited. The mean number of years post-graduation was 26 (range, 19– 32 years). The median number of LCS cases performed by the experts was 700 (range, 219–2700). Our scale consisted of 35 items. Cronbach’s alphas of the 1 and 2 rounds were calculated to be 0.85 and 0.81, respectively. All ten experts answered the first round and 20 items were excluded. The second round was answered by all experts and no items were deleted. Our new scale may be applicable in future clinical studies evaluating surgical skills in LCS.
{"title":"Development of an assessment tool for laparoscopic sigmoidectomy using the Delphi method","authors":"Yujiro Nakayama, Hidetaka Kawamura, Hiroshi Kobayashi, Yukitoshi Todate, R. Matsunaga, T. Miyakawa, M. Honda","doi":"10.4993/acrt.28.137","DOIUrl":"https://doi.org/10.4993/acrt.28.137","url":null,"abstract":"Several tools to assess surgeons’ skills in laparoscopic surgeries have developed; nevertheless, the tools have not been developed to accommodate the Japanese guidelines and common surgical methods. Trainee surgeons would then not be able to learn the critical steps and important points of LCS procedures using the assessment tool. To fill the gap, we launched the “Development of an Assessment tool for Laparoscopic Colectomy” (ASLAC) project to develop a reliable tool to assess laparoscopic sigmoidectomy. The study consisted of two steps: cognitive task analysis (CTA) and application of the Delphi method. Consensus was defined in advance using Cronbach’s alpha ≥0.8. Items for which 70% of experts cited a value of ≥4 (agree or strongly agree) were used as novel tool. Ten expert surgeons (considered “qualified surgeons” by the Endoscopic Surgical Skill Qualification System in Japan) were recruited. The mean number of years post-graduation was 26 (range, 19– 32 years). The median number of LCS cases performed by the experts was 700 (range, 219–2700). Our scale consisted of 35 items. Cronbach’s alphas of the 1 and 2 rounds were calculated to be 0.85 and 0.81, respectively. All ten experts answered the first round and 20 items were excluded. The second round was answered by all experts and no items were deleted. Our new scale may be applicable in future clinical studies evaluating surgical skills in LCS.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41987129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Surina, M. Sata, Tanggis, Satomi Fujiwara, S. Hisata, Takuji Suzuki, N. Mato, K. Hagiwara
Background and Aims: Cancer cells can be isolated from malignant pleural effusion (MPE). They may provide an ex- perimental system to explore the cell biology of lung cancer. Anti-VEGF antibody has been reported to efficiently control MPE, which contains a high concentration of VEGF; this suggests the important role of VEGF acting on MPE. We aimed to develop a method for culturing cancer cells from MPE and investigate the role of VEGF in MPE. Methods: Cancer cells in MPE were obtained from six patients and cultured using three different types of media, includ- ing (1) supernatant of MPE, (2) 1:1 mixture of supernatant and common culture medium, and (3) common culture medium only. We further co-cultured cancer cells with γ-irradiated mouse 3T3-J2 embryonic fibroblasts. Using co-cultured cells, we investigated the effect of VEGF on cancer cells and measured the amount of VEGF secreted from them. Results: Cancer cells were poorly maintained in three types of media, while well proliferated when co-cultured with 3T3- J2 feeder cells. VEGF didn’t affect cell proliferation. VEGF secreted from cancer cells didn’t reach to a concentration that may show an apparent biological effect. Conclusion: Proliferation of cancer cells in MPE requires a specific factor(s) in addition to those residing in the supernatant of MPE or conventional culture medium. Co-cultured cancer cells suggested a lack of proliferative effect of VEGF. The concentration of VEGF produced by cancer cells was not sufficient to exert a biological effect. Co-cultured cancer cells may provide a valuable experimental system for further cancer studies.
{"title":"Cultivation of cancer cells in malignant pleural effusion and their use in a vascular endothelial growth factor study","authors":"Surina, M. Sata, Tanggis, Satomi Fujiwara, S. Hisata, Takuji Suzuki, N. Mato, K. Hagiwara","doi":"10.4993/acrt.28.111","DOIUrl":"https://doi.org/10.4993/acrt.28.111","url":null,"abstract":"Background and Aims: Cancer cells can be isolated from malignant pleural effusion (MPE). They may provide an ex- perimental system to explore the cell biology of lung cancer. Anti-VEGF antibody has been reported to efficiently control MPE, which contains a high concentration of VEGF; this suggests the important role of VEGF acting on MPE. We aimed to develop a method for culturing cancer cells from MPE and investigate the role of VEGF in MPE. Methods: Cancer cells in MPE were obtained from six patients and cultured using three different types of media, includ- ing (1) supernatant of MPE, (2) 1:1 mixture of supernatant and common culture medium, and (3) common culture medium only. We further co-cultured cancer cells with γ-irradiated mouse 3T3-J2 embryonic fibroblasts. Using co-cultured cells, we investigated the effect of VEGF on cancer cells and measured the amount of VEGF secreted from them. Results: Cancer cells were poorly maintained in three types of media, while well proliferated when co-cultured with 3T3- J2 feeder cells. VEGF didn’t affect cell proliferation. VEGF secreted from cancer cells didn’t reach to a concentration that may show an apparent biological effect. Conclusion: Proliferation of cancer cells in MPE requires a specific factor(s) in addition to those residing in the supernatant of MPE or conventional culture medium. Co-cultured cancer cells suggested a lack of proliferative effect of VEGF. The concentration of VEGF produced by cancer cells was not sufficient to exert a biological effect. Co-cultured cancer cells may provide a valuable experimental system for further cancer studies.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48183843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Yoshimatsu, M. Satake, T. Kono, Shin-ichi Asaka, Megumi Sano, A. Kodera, Hiroyuki Maeda, Hideyuki Yokokawa, Yasufumi Yamada, S. Okayama, H. Yokomizo, S. Shiozawa
Introduction: The clinicopathological significance of poorly differentiated cluster (PDC) at the invasive front in colorectal cancer (CRC) has been reported. We analyzed whether PDC reflects malignant findings in patients with CRC invading beyond the muscle layer. Patients and methods: Sixty-eight patients who underwent surgery between January 2015 and June 2016 for CRC invading beyond the T3 (median observation period: 32.2 months) were enrolled. The relationship between PDC and clinicopatho- logical factors was analyzed. PDC was graded based on the criteria described in a report by Ueno H et al. Results: Tumor location was at the proximal colon in 26 cases, distal colon in 34 cases, and rectum in eight cases. The number of cases with ly2,3 and v2,3 was 24 and 38, respectively. Thirty-eight cases had node positive and 11 cases had distant metastases, including 10 cases with hematogenous metastasis and four cases with peritoneal metastasis. The number of cases with stages II, III, and IV was 28, 28, and 12, respectively. The number of cases with PDC grades 1 (G1), 2 (G2), and 3 (G3) was 48, 15, and 5, respectively. A PDC G2 or G3 is a risk factor for lymph node and distant metastases. Cases with PDC G2 or G3 had significantly poor overall survival (OS) ( p < 0.0001). In cases with curability (cur) A resection for stage II or III, disease-free survival (DFS) and OS were significantly poorer in cases with PDC G2 or G3 ( p = 0.0022 and p = 0.0049, respectively). Conclusion: Analyses concerning PDC at the invasive front in cases with CRC invading beyond the muscle layer were per- formed. As the stage progresses, cases with PDC G2 and G3 increased significantly. In cases with PDC G2 and G3, the DFS and OS were significantly poorer. These results suggest that PDC is a malignant predictor in patients with CRC invading the T3 or deeper.
{"title":"Clinical Impact of Poorly Differentiated Cluster at the Invasive Front in Colorectal Cancer Invading beyond the Muscle Layer","authors":"K. Yoshimatsu, M. Satake, T. Kono, Shin-ichi Asaka, Megumi Sano, A. Kodera, Hiroyuki Maeda, Hideyuki Yokokawa, Yasufumi Yamada, S. Okayama, H. Yokomizo, S. Shiozawa","doi":"10.4993/acrt.28.107","DOIUrl":"https://doi.org/10.4993/acrt.28.107","url":null,"abstract":"Introduction: The clinicopathological significance of poorly differentiated cluster (PDC) at the invasive front in colorectal cancer (CRC) has been reported. We analyzed whether PDC reflects malignant findings in patients with CRC invading beyond the muscle layer. Patients and methods: Sixty-eight patients who underwent surgery between January 2015 and June 2016 for CRC invading beyond the T3 (median observation period: 32.2 months) were enrolled. The relationship between PDC and clinicopatho- logical factors was analyzed. PDC was graded based on the criteria described in a report by Ueno H et al. Results: Tumor location was at the proximal colon in 26 cases, distal colon in 34 cases, and rectum in eight cases. The number of cases with ly2,3 and v2,3 was 24 and 38, respectively. Thirty-eight cases had node positive and 11 cases had distant metastases, including 10 cases with hematogenous metastasis and four cases with peritoneal metastasis. The number of cases with stages II, III, and IV was 28, 28, and 12, respectively. The number of cases with PDC grades 1 (G1), 2 (G2), and 3 (G3) was 48, 15, and 5, respectively. A PDC G2 or G3 is a risk factor for lymph node and distant metastases. Cases with PDC G2 or G3 had significantly poor overall survival (OS) ( p < 0.0001). In cases with curability (cur) A resection for stage II or III, disease-free survival (DFS) and OS were significantly poorer in cases with PDC G2 or G3 ( p = 0.0022 and p = 0.0049, respectively). Conclusion: Analyses concerning PDC at the invasive front in cases with CRC invading beyond the muscle layer were per- formed. As the stage progresses, cases with PDC G2 and G3 increased significantly. In cases with PDC G2 and G3, the DFS and OS were significantly poorer. These results suggest that PDC is a malignant predictor in patients with CRC invading the T3 or deeper.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48612362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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