{"title":"Genistein impairs proliferation and induces apoptosis in human leukemia MOLT-4 cells by down-regulation of anti-apoptotic proteins","authors":"Firoozeh Abolhasani Zadeh, Mahsa Mardasi, M. Rahbaran, Sadegh Shojaei Baghini, Sahel Rahimi, Parastoo Tambrchi, Ehsan Razeghian","doi":"10.4993/acrt.30.22","DOIUrl":"https://doi.org/10.4993/acrt.30.22","url":null,"abstract":"","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41566275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Kidney function test (KFT) is a routine laboratory examination used in the diagnosis of many disorders, the kidney participates in several essential functions in the human body, and kidney dysfunction can lead to morbidity and mortality. Therefore, studying the levels of KFT in early diagnosed cancer patients can identify how the kidney perform when cancer begins, and which parameter of KFT is affected early. Objective: This study aimed to evaluate levels of kidneys function profile including blood urea, creatinine, sodium (Na), potassium (K), and chloride in untreated cancer patients. Patients and methods: 211 participants including 44 healthy controls and 167 patients diagnosed as early cancer were enrolled in this study in Taif city, and this study was performed at King Faisal Hospital (KFH) and Taif University. Serum levels of blood urea, creatinine, sodium (Na), potassium (K), and chloride were analyzed. The total number of patients was 167 and healthy controls were 44. Types of cancer in the patients included in this study were 49 breast cancer, 45 gastrointestinal tract cancer, 39 gynecological tumors, 17 head and neck cancer and 17 respiratory cancer. Statistical assessment was done by applying T-test, Chi-square, odds ratio. Results: Sodium, potassium, creatinine and chloride levels were significantly higher in cancer patients compared to the healthy controls and the urea was normal and nothing was significant. Conclusion: Most common electrolytes abnormality increased in our study group of cancer patients. A sudden death could be resulted when the potassium level increased rapidly. Dysregulation in urea, chloride and creatinine could be a cancer marker and lead to fatal problems.
{"title":"Dysregulation of serum electrolytes is detected in untreated cancer patients in Taif city","authors":"O. Abdulaziz, M. Almehmadi","doi":"10.4993/acrt.29.126","DOIUrl":"https://doi.org/10.4993/acrt.29.126","url":null,"abstract":"Background: Kidney function test (KFT) is a routine laboratory examination used in the diagnosis of many disorders, the kidney participates in several essential functions in the human body, and kidney dysfunction can lead to morbidity and mortality. Therefore, studying the levels of KFT in early diagnosed cancer patients can identify how the kidney perform when cancer begins, and which parameter of KFT is affected early. Objective: This study aimed to evaluate levels of kidneys function profile including blood urea, creatinine, sodium (Na), potassium (K), and chloride in untreated cancer patients. Patients and methods: 211 participants including 44 healthy controls and 167 patients diagnosed as early cancer were enrolled in this study in Taif city, and this study was performed at King Faisal Hospital (KFH) and Taif University. Serum levels of blood urea, creatinine, sodium (Na), potassium (K), and chloride were analyzed. The total number of patients was 167 and healthy controls were 44. Types of cancer in the patients included in this study were 49 breast cancer, 45 gastrointestinal tract cancer, 39 gynecological tumors, 17 head and neck cancer and 17 respiratory cancer. Statistical assessment was done by applying T-test, Chi-square, odds ratio. Results: Sodium, potassium, creatinine and chloride levels were significantly higher in cancer patients compared to the healthy controls and the urea was normal and nothing was significant. Conclusion: Most common electrolytes abnormality increased in our study group of cancer patients. A sudden death could be resulted when the potassium level increased rapidly. Dysregulation in urea, chloride and creatinine could be a cancer marker and lead to fatal problems.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42517942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ALDH1 expression in inflammatory breast cancer tumor using Real-time RT-PCR gene expression quantifications: Moroccan prospective study","authors":"Fouzia Mamouch, Abdelilah Laraqui, Narjiss Berrada, Hicham El Rhaffouli, Basma Elkhannousi, Tahar Bajjou, Yassine Sekhsokh, Hassan Errihani","doi":"10.4993/acrt.29.153","DOIUrl":"https://doi.org/10.4993/acrt.29.153","url":null,"abstract":"","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48849994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jamila Kerouad, H. Errihani, F. Ouasmani, B. Benazzouz, S. Chbicheb, A. Mesfioui
Objective: In Morocco, 3 246 new cases of upper aerodigestive tract cancer (UADTC) were diagnosed in 2020. The main risk factors are tobacco and alcohol; other risk factors have been identified or suspected. This study aimed to investigate potential risk factors associated with the UADTC sites. Methods: A cross-sectional study has been conducted from December 2018 to February 2020 at the National Institute of Oncology in Rabat. Data were collected using a face-to-face structured and pre-tested questionnaire among patients with UADTC. Medical records were abstracted to complete clinical information. The use of a Chi-Square test with a value of a 95% confidence level helped to predict the association between potential factors and UADTC. Results: 201 patients agreed to take part in the study, with an average age of 54.1 years; 48.3% of the participants were illiterate; 74.1% were poor, and 52.7% were diagnosed at stage IV. The Pearson Chi-Square test showed a significant relation- ship between smoking and cancers of the oral cavity (p = 0.039), nasopharynx (p < 0.001), and larynx (p < 0.001). Alcohol was also associated with cancers of the oral cavity (p = 0.049), nasopharynx (p < 0.001), oropharynx (p = 0.047), and larynx (p < 0.001). In addition, a significant relationship was also demonstrated for both tobacco and alcohol users and cancers of the oral cavity (p = 0.041), nasopharynx (p < 0.001), oropharynx (p = 0.042), and larynx (p < 0.001). Oral hygiene (p = 0.049), and prosthetic irritation (p < 0.001) were associated with oral cavity cancers only. Conclusion: In the present study, the identified at-risk individuals could be admitted for clinical examination and for fo- cused preventive treatment measures.
{"title":"Tumor site related factors in patients with upper aerodigestive tract cancer in Morocco","authors":"Jamila Kerouad, H. Errihani, F. Ouasmani, B. Benazzouz, S. Chbicheb, A. Mesfioui","doi":"10.4993/acrt.29.161","DOIUrl":"https://doi.org/10.4993/acrt.29.161","url":null,"abstract":"Objective: In Morocco, 3 246 new cases of upper aerodigestive tract cancer (UADTC) were diagnosed in 2020. The main risk factors are tobacco and alcohol; other risk factors have been identified or suspected. This study aimed to investigate potential risk factors associated with the UADTC sites. Methods: A cross-sectional study has been conducted from December 2018 to February 2020 at the National Institute of Oncology in Rabat. Data were collected using a face-to-face structured and pre-tested questionnaire among patients with UADTC. Medical records were abstracted to complete clinical information. The use of a Chi-Square test with a value of a 95% confidence level helped to predict the association between potential factors and UADTC. Results: 201 patients agreed to take part in the study, with an average age of 54.1 years; 48.3% of the participants were illiterate; 74.1% were poor, and 52.7% were diagnosed at stage IV. The Pearson Chi-Square test showed a significant relation- ship between smoking and cancers of the oral cavity (p = 0.039), nasopharynx (p < 0.001), and larynx (p < 0.001). Alcohol was also associated with cancers of the oral cavity (p = 0.049), nasopharynx (p < 0.001), oropharynx (p = 0.047), and larynx (p < 0.001). In addition, a significant relationship was also demonstrated for both tobacco and alcohol users and cancers of the oral cavity (p = 0.041), nasopharynx (p < 0.001), oropharynx (p = 0.042), and larynx (p < 0.001). Oral hygiene (p = 0.049), and prosthetic irritation (p < 0.001) were associated with oral cavity cancers only. Conclusion: In the present study, the identified at-risk individuals could be admitted for clinical examination and for fo- cused preventive treatment measures.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47428740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Miyakawa, Hidetaka Kawamura, R. Yamamoto, K. Hashimoto, Hiroshi Kobayashi, Cong Yue, Soshi Hori, T. Hirano, M. Honda
{"title":"Risk of postoperative urinary retention with early removal of the urinary catheter after surgery with epidural analgesia: A systematic review and meta-analysis","authors":"T. Miyakawa, Hidetaka Kawamura, R. Yamamoto, K. Hashimoto, Hiroshi Kobayashi, Cong Yue, Soshi Hori, T. Hirano, M. Honda","doi":"10.4993/acrt.29.178","DOIUrl":"https://doi.org/10.4993/acrt.29.178","url":null,"abstract":"","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47811579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hamed Hosseinalizadeh, Mehrdad Mahmoodpour, A. Ebrahimi
Cancer is the leading cause of death worldwide. Despite significant advances in cancer treatment, morbidity and mortality rates remain high. Tumor heterogeneity, particularly intertumoral heterogeneity, is a major cause of cancer therapy failure, underpinning tumor treatment problems and a variety of available therapeutic strategies, including molecularly targeted therapies. Recent advances in massively parallel sequencing and digital genomic techniques suggest that cell-free circulating tumor DNA (ctDNA) can be used as a “liquid biopsy.” In the case of breast cancer, ctDNA found in plasma can be used to non-invasively scan tumor genomes and assess tumor burden. ctDNA in plasma can be used to identify important genetic anomalies, track treatment responses, uncover drug resistance, and detect disease progression before clinical and radiographic confirmation. Furthermore, ctDNA can be used to identify tumor heterogeneity and metastasis-specific mutations, providing information to aid in patient treatment. We focused on the current state of cell-free ctDNA, including ctDNA biology, recently developed ctDNA detection techniques, and breast cancer-specific detection methods, with a focus on clinical applications of ctDNA-based biomarkers in breast oncology.
{"title":"The Role of Cell-Free Circulating DNA in the Diagnosis and Prognosis of Breast Cancer","authors":"Hamed Hosseinalizadeh, Mehrdad Mahmoodpour, A. Ebrahimi","doi":"10.4993/acrt.29.169","DOIUrl":"https://doi.org/10.4993/acrt.29.169","url":null,"abstract":"Cancer is the leading cause of death worldwide. Despite significant advances in cancer treatment, morbidity and mortality rates remain high. Tumor heterogeneity, particularly intertumoral heterogeneity, is a major cause of cancer therapy failure, underpinning tumor treatment problems and a variety of available therapeutic strategies, including molecularly targeted therapies. Recent advances in massively parallel sequencing and digital genomic techniques suggest that cell-free circulating tumor DNA (ctDNA) can be used as a “liquid biopsy.” In the case of breast cancer, ctDNA found in plasma can be used to non-invasively scan tumor genomes and assess tumor burden. ctDNA in plasma can be used to identify important genetic anomalies, track treatment responses, uncover drug resistance, and detect disease progression before clinical and radiographic confirmation. Furthermore, ctDNA can be used to identify tumor heterogeneity and metastasis-specific mutations, providing information to aid in patient treatment. We focused on the current state of cell-free ctDNA, including ctDNA biology, recently developed ctDNA detection techniques, and breast cancer-specific detection methods, with a focus on clinical applications of ctDNA-based biomarkers in breast oncology.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46611226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Whether human leukocyte antigens (HLAs) and human endogenous retroviruses (HERVs) affect therapeutic outcomes is unknown. Here, we focused on the similarity between HERV and human immunodeficiency virus (HIV) genes. Methods: By comparing training and validation sets in pooled 2,049 gastric cancers, we evaluated the significance of baseline HLA examination in clinical treatment response. HLA-restricted CD8 + cytotoxic T-lymphocyte (CTL) epitopes on HERV and HIV genes were predicted using bioinformatics. HLA-restricted putative HERV peptides were selected based on the similarity of HLA-restricted HIV peptides. Changes in CD8 + cells were compared at baseline and 1 year after gastrectomy. Results: We identified 53 fully recovering subjects who received effective therapies in the validation set, based on the HLA of 101 patients who received effective therapies in the training set. We found putative 84 HERV-derived peptides that might have induced HLA-restricted CTL by administering therapies in 2041 subjects. We identified 155 subjects, whose CD8 + cells increased significantly after administering therapies in only females (paired t -tests, P = .005), resulting in significantly better survival compared with CTL (-) patients (hazard ratio [HR], 5.05; 95% CI, 3.42 to 8.92; P < .0001 [female: HR, 8.46; 95% CI, 3.15 to 22.72; P < .0001, male: HR, 3.89; 95% CI, 2.20 to 6.88; P < .0001]). All CTL (+) females received effective therapy and CTL (+) unclassified patients survived during the follow-up period. Conclusions: We confirmed the clinical significance of HLA. Research on HLA-restricted HERV gene-derived peptides may reveal the central mechanism of sex bias in therapeutic responses.
{"title":"Association of HLA-restricted HERV-derived peptide-related cytotoxic T-lymphocyte induction and sex bias in therapeutic responses in gastric cancer: Secondary Analysis of Data from 3 Randomized Trials and an Observational Study from 1977 to 2011","authors":"K. Ogoshi, S. Takenoshita, K. Isono","doi":"10.4993/acrt.29.135","DOIUrl":"https://doi.org/10.4993/acrt.29.135","url":null,"abstract":"Introduction: Whether human leukocyte antigens (HLAs) and human endogenous retroviruses (HERVs) affect therapeutic outcomes is unknown. Here, we focused on the similarity between HERV and human immunodeficiency virus (HIV) genes. Methods: By comparing training and validation sets in pooled 2,049 gastric cancers, we evaluated the significance of baseline HLA examination in clinical treatment response. HLA-restricted CD8 + cytotoxic T-lymphocyte (CTL) epitopes on HERV and HIV genes were predicted using bioinformatics. HLA-restricted putative HERV peptides were selected based on the similarity of HLA-restricted HIV peptides. Changes in CD8 + cells were compared at baseline and 1 year after gastrectomy. Results: We identified 53 fully recovering subjects who received effective therapies in the validation set, based on the HLA of 101 patients who received effective therapies in the training set. We found putative 84 HERV-derived peptides that might have induced HLA-restricted CTL by administering therapies in 2041 subjects. We identified 155 subjects, whose CD8 + cells increased significantly after administering therapies in only females (paired t -tests, P = .005), resulting in significantly better survival compared with CTL (-) patients (hazard ratio [HR], 5.05; 95% CI, 3.42 to 8.92; P < .0001 [female: HR, 8.46; 95% CI, 3.15 to 22.72; P < .0001, male: HR, 3.89; 95% CI, 2.20 to 6.88; P < .0001]). All CTL (+) females received effective therapy and CTL (+) unclassified patients survived during the follow-up period. Conclusions: We confirmed the clinical significance of HLA. Research on HLA-restricted HERV gene-derived peptides may reveal the central mechanism of sex bias in therapeutic responses.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45893557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Yunusova, T. Aoyama, Rustam Amanullayev, J. Rizaev, G. Ikramov, J. Sakamoto, Bakhodir Halmanov, S. Mamarajabov
Сysts of the neck are congenital cystic lesions of the neck, often presenting in childhood. Complete surgical excision is the treatment of choice for these lesions. Recurrence of cystic lesions of the neck after incomplete excision is fraught with complications due to the need for a second surgery and complications of the recurrent cyst itself. We herein report the de- tails of recurrent cysts of the neck presenting at 3, 6, 12 and 18 months postoperatively.
{"title":"Sonography and magnetic resonance tomography in monitoring of recurrent cysts lesions of the neck","authors":"L. Yunusova, T. Aoyama, Rustam Amanullayev, J. Rizaev, G. Ikramov, J. Sakamoto, Bakhodir Halmanov, S. Mamarajabov","doi":"10.4993/acrt.29.131","DOIUrl":"https://doi.org/10.4993/acrt.29.131","url":null,"abstract":"Сysts of the neck are congenital cystic lesions of the neck, often presenting in childhood. Complete surgical excision is the treatment of choice for these lesions. Recurrence of cystic lesions of the neck after incomplete excision is fraught with complications due to the need for a second surgery and complications of the recurrent cyst itself. We herein report the de- tails of recurrent cysts of the neck presenting at 3, 6, 12 and 18 months postoperatively.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48513281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tohid Rostamian, S. Hekmatimoghaddam, F. Pourrajab
The drug 6-thioguanine (6-TG) is one of the thiopurines successfully used in oncology, especially for acute myeloid leukemia (AML). It is proposed to act as an epigenetic drug affecting DNA methylation. The aim of this study was to clarify the effect of 6-TG on the proliferation, viability and expression of genes coding for the enzymes DNA methyltransferase 3A and DNA methyltransferase 3B (DNMTs) as well as histone deacetylase 3 (HDAC3) and histone deacetylase 7 (HDAC7) in the human promyelocytic AML cell line HL60. In this experimental study, HL60 cells and also normal peripheral blood mononuclear cells (PBMCs) were grown in RPMI 1640 medium containing 10% fetal bovine serum. They were then treated with 6-TG at their exponential growth phase. Cell viability was monitored using the Cell Counting Kit-8 assay with an enzyme-linked immunosorbent assay (ELISA) reader. The expressions of the above mentioned 4 genes were quantified using real-time PCR. 6-TG could inhibit the proliferation of HL60 cells and decrease their viability. In HL60 cells, as compared to normal PBMCs, 6-TG significantly decreased HDAC3 (p = 0.0034) as well as DNMT3B (p = 0.03) and HDAC7 (p = 0.0031) gene expressions, but increased the expression of DNMT3A gene (p = 0.16) after normalization to GAPDH as the housekeeping gene.These findings suggest that the altered expression of DNMT3A , DNMT3B , HDAC3 and HDAC7 genes is responsible for at least part of the antitumor properties of 6-TG, providing an insight into the mechanism of its action as an epigenetic drug.
{"title":"The Impact of 6-Thioguanine on Epigenetics of Acute Myeloid Leukemia","authors":"Tohid Rostamian, S. Hekmatimoghaddam, F. Pourrajab","doi":"10.4993/ACRT.29.121","DOIUrl":"https://doi.org/10.4993/ACRT.29.121","url":null,"abstract":"The drug 6-thioguanine (6-TG) is one of the thiopurines successfully used in oncology, especially for acute myeloid leukemia (AML). It is proposed to act as an epigenetic drug affecting DNA methylation. The aim of this study was to clarify the effect of 6-TG on the proliferation, viability and expression of genes coding for the enzymes DNA methyltransferase 3A and DNA methyltransferase 3B (DNMTs) as well as histone deacetylase 3 (HDAC3) and histone deacetylase 7 (HDAC7) in the human promyelocytic AML cell line HL60. In this experimental study, HL60 cells and also normal peripheral blood mononuclear cells (PBMCs) were grown in RPMI 1640 medium containing 10% fetal bovine serum. They were then treated with 6-TG at their exponential growth phase. Cell viability was monitored using the Cell Counting Kit-8 assay with an enzyme-linked immunosorbent assay (ELISA) reader. The expressions of the above mentioned 4 genes were quantified using real-time PCR. 6-TG could inhibit the proliferation of HL60 cells and decrease their viability. In HL60 cells, as compared to normal PBMCs, 6-TG significantly decreased HDAC3 (p = 0.0034) as well as DNMT3B (p = 0.03) and HDAC7 (p = 0.0031) gene expressions, but increased the expression of DNMT3A gene (p = 0.16) after normalization to GAPDH as the housekeeping gene.These findings suggest that the altered expression of DNMT3A , DNMT3B , HDAC3 and HDAC7 genes is responsible for at least part of the antitumor properties of 6-TG, providing an insight into the mechanism of its action as an epigenetic drug.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45325195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akio Higuchi, T. Aoyama, Yukari Takahashi, Norihiro Akimoto, K. Tsuchiya, M. Kurihara, Yosuke Atsumi, K. Kazama, A. Kato, Taichi Kawabe, S. Sawazaki, M. Numata, H. Tamagawa, N. Yukawa, H. Saeki, Y. Rino, M. Masuda, H. Matsukawa
Background: We investigated the risk factors for recurrence in high risk stage II colorectal cancer patients over 75 years old. Methods: This study included 79 patients who underwent primary colorectal surgery at Minami Kyousai Hospital from January 2015 to June 2019. The inclusion criteria were as follows: (1) age over 75 years old, (2) histologically confirmed stage II colorectal adenocarcinoma after curative surgery, and (3) no other active malignancy. A Cox proportional hazards model was used to identify the risk factors for recurrence. Results: The recurrence free survival rates at 1, 2, and 3 years after surgery were 92.6%, 78.8%, and 61.9%. The risk factors for recurrence were tumor location and lymph-node dissection. Conclusion: This study revealed that left-sided colorectal cancer and under D2 dissection are risk factors for recurrence of stage II colorectal cancer in the elderly. Patients with these risk factors should be considered for adjuvant chemotherapy.
{"title":"Recurrence risk factors in elderly patients with stage II colorectal cancer","authors":"Akio Higuchi, T. Aoyama, Yukari Takahashi, Norihiro Akimoto, K. Tsuchiya, M. Kurihara, Yosuke Atsumi, K. Kazama, A. Kato, Taichi Kawabe, S. Sawazaki, M. Numata, H. Tamagawa, N. Yukawa, H. Saeki, Y. Rino, M. Masuda, H. Matsukawa","doi":"10.4993/ACRT.29.5","DOIUrl":"https://doi.org/10.4993/ACRT.29.5","url":null,"abstract":"Background: We investigated the risk factors for recurrence in high risk stage II colorectal cancer patients over 75 years old. Methods: This study included 79 patients who underwent primary colorectal surgery at Minami Kyousai Hospital from January 2015 to June 2019. The inclusion criteria were as follows: (1) age over 75 years old, (2) histologically confirmed stage II colorectal adenocarcinoma after curative surgery, and (3) no other active malignancy. A Cox proportional hazards model was used to identify the risk factors for recurrence. Results: The recurrence free survival rates at 1, 2, and 3 years after surgery were 92.6%, 78.8%, and 61.9%. The risk factors for recurrence were tumor location and lymph-node dissection. Conclusion: This study revealed that left-sided colorectal cancer and under D2 dissection are risk factors for recurrence of stage II colorectal cancer in the elderly. Patients with these risk factors should be considered for adjuvant chemotherapy.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41393286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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