Pub Date : 2022-09-07DOI: 10.4274/gulhane.galenos.2022.93585
Kübra Tel Adıgüzel, Ö. Köroğlu
{"title":"Caffeine intake and bone mineral density in postmenopausal women","authors":"Kübra Tel Adıgüzel, Ö. Köroğlu","doi":"10.4274/gulhane.galenos.2022.93585","DOIUrl":"https://doi.org/10.4274/gulhane.galenos.2022.93585","url":null,"abstract":"","PeriodicalId":35658,"journal":{"name":"Gulhane Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44093206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-07DOI: 10.4274/gulhane.galenos.2022.38039
Zülfikar Akelma, Melikşah Keskin, Ş. Savaş Erdeve, N. Bursa, O. Çelik, Ersan Imrat, M. M. Ülgü, M. Çağlayan, N. Ata, Ş. Birinci
{"title":"Decreased vitamin D levels in children and adolescents with Celiac disease: A nationwide cross-sectional study","authors":"Zülfikar Akelma, Melikşah Keskin, Ş. Savaş Erdeve, N. Bursa, O. Çelik, Ersan Imrat, M. M. Ülgü, M. Çağlayan, N. Ata, Ş. Birinci","doi":"10.4274/gulhane.galenos.2022.38039","DOIUrl":"https://doi.org/10.4274/gulhane.galenos.2022.38039","url":null,"abstract":"","PeriodicalId":35658,"journal":{"name":"Gulhane Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47553569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-07DOI: 10.4274/gulhane.galenos.2021.67209
Neslihan Demirel Öğüt, P. Eşme, E. Çalışkan
Down syndrome is the most common chromosomal disorder associated with skin conditions, including psoriasis and hidradenitis suppurativa. Patients with Down syndrome are more likely to be overweight or obese and diagnosed with metabolic comorbidities such as cardiovascular disorders, inflammatory joint diseases as in psoriasis and hidradenitis suppurativa. Although both hidradenitis suppurativa and psoriasis are associated with Down syndrome, concurrent psoriasis and hidradenitis suppurativa in the same patient with Down syndrome have not been reported in the literature. Here, we describe three patients with Down syndrome having both hidradenitis suppurativa and psoriasis by discussing the common etiopathogenesis considering the current literature.
{"title":"Hidradenitis suppurativa and psoriasis coexistence in patients with Down syndrome: A case series","authors":"Neslihan Demirel Öğüt, P. Eşme, E. Çalışkan","doi":"10.4274/gulhane.galenos.2021.67209","DOIUrl":"https://doi.org/10.4274/gulhane.galenos.2021.67209","url":null,"abstract":"Down syndrome is the most common chromosomal disorder associated with skin conditions, including psoriasis and hidradenitis suppurativa. Patients with Down syndrome are more likely to be overweight or obese and diagnosed with metabolic comorbidities such as cardiovascular disorders, inflammatory joint diseases as in psoriasis and hidradenitis suppurativa. Although both hidradenitis suppurativa and psoriasis are associated with Down syndrome, concurrent psoriasis and hidradenitis suppurativa in the same patient with Down syndrome have not been reported in the literature. Here, we describe three patients with Down syndrome having both hidradenitis suppurativa and psoriasis by discussing the common etiopathogenesis considering the current literature.","PeriodicalId":35658,"journal":{"name":"Gulhane Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45639537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-07DOI: 10.4274/gulhane.galenos.2022.75437
B. S. Uysal, Murat Yüksel, M. C. Özmen, B. Aydın, K. Bilgihan
and other from irreversible adverse effects of ultraviolet (UV) irradiation based on experimental and clinical research (2,3). A significant portion of keratoconus patients (25%) are diagnosed at an advanced stage, with a corneal thickness of than 400 and these patients are at a higher risk of potential achieve safe Aims: To evaluate the efficacy and safety of transepithelial diluted alcohol and iontophoresis-assisted corneal cross-linking (DAI-CXL) and compare 24-month visual and topographic outcomes with accelerated CXL using hypo-osmolar riboflavin (A-CXL) in keratoconus patients with thin corneas (below 400 μm with epithelium). Methods: This retrospective study included keratoconus patients who underwent DAI-CXL or A-CXL. Uncorrected and corrected distance visual acuity (UDVA and CDVA) and data obtained from corneal topography were analyzed at baseline and 12 and 24 months of follow-up. Corneal demarcation line depth (DLD) at 1 month and corneal endothelial cell density (ECD) at 24 months were also evaluated. Results: The study included 25 eyes of 25 keratoconus patients (mean age: 25.48±6.69 years, male: 52%). DAI-CXL and A-CXL groups consisted of 13 and 12 patients, respectively. In both groups, median UDVA improved significantly at 24 months (p<0.05) whereas CDVA was similar despite a trend towards improvement. Median K-max decreased by 2.77 [interquartile range (IQR): 2.67] D and 2.24 (IQR: 4.38) D in DAI-CXL group (p=0.033) and A-CXL group (p=0.060), respectively. Corneal HOAs showed a significant improvement in only the DAI-CXL group (p=0.004). Average DLD was 237±67 μm in DAI-CXL and 242±57 μm in A-CXL (p=0.346). No significant changes in ECD were observed in both groups. Median follow-up changes in UDVA, CDVA, K-max, HOAs, and ECD were similar in the groups. Conclusions: We observed similar efficacy of transepithelial DAI-CXL to A-CXL in slowing down the progression of keratoconus in thin corneas without notable effects during a 24-month follow-up period.
{"title":"Epithelium-off corneal cross-linking versus transepithelial diluted alcohol and iontophoresis-assisted corneal cross-linking in keratoconus patients with thin corneas","authors":"B. S. Uysal, Murat Yüksel, M. C. Özmen, B. Aydın, K. Bilgihan","doi":"10.4274/gulhane.galenos.2022.75437","DOIUrl":"https://doi.org/10.4274/gulhane.galenos.2022.75437","url":null,"abstract":"and other from irreversible adverse effects of ultraviolet (UV) irradiation based on experimental and clinical research (2,3). A significant portion of keratoconus patients (25%) are diagnosed at an advanced stage, with a corneal thickness of than 400 and these patients are at a higher risk of potential achieve safe Aims: To evaluate the efficacy and safety of transepithelial diluted alcohol and iontophoresis-assisted corneal cross-linking (DAI-CXL) and compare 24-month visual and topographic outcomes with accelerated CXL using hypo-osmolar riboflavin (A-CXL) in keratoconus patients with thin corneas (below 400 μm with epithelium). Methods: This retrospective study included keratoconus patients who underwent DAI-CXL or A-CXL. Uncorrected and corrected distance visual acuity (UDVA and CDVA) and data obtained from corneal topography were analyzed at baseline and 12 and 24 months of follow-up. Corneal demarcation line depth (DLD) at 1 month and corneal endothelial cell density (ECD) at 24 months were also evaluated. Results: The study included 25 eyes of 25 keratoconus patients (mean age: 25.48±6.69 years, male: 52%). DAI-CXL and A-CXL groups consisted of 13 and 12 patients, respectively. In both groups, median UDVA improved significantly at 24 months (p<0.05) whereas CDVA was similar despite a trend towards improvement. Median K-max decreased by 2.77 [interquartile range (IQR): 2.67] D and 2.24 (IQR: 4.38) D in DAI-CXL group (p=0.033) and A-CXL group (p=0.060), respectively. Corneal HOAs showed a significant improvement in only the DAI-CXL group (p=0.004). Average DLD was 237±67 μm in DAI-CXL and 242±57 μm in A-CXL (p=0.346). No significant changes in ECD were observed in both groups. Median follow-up changes in UDVA, CDVA, K-max, HOAs, and ECD were similar in the groups. Conclusions: We observed similar efficacy of transepithelial DAI-CXL to A-CXL in slowing down the progression of keratoconus in thin corneas without notable effects during a 24-month follow-up period.","PeriodicalId":35658,"journal":{"name":"Gulhane Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42405149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-07DOI: 10.4274/gulhane.galenos.2021.40427
Süleyman Baş, Funda Müşerref Türkmen
{"title":"Changes in neutrophil-to-lymphocyte ratio following treatment with dapagliflozin in patients with type 2 diabetes mellitus","authors":"Süleyman Baş, Funda Müşerref Türkmen","doi":"10.4274/gulhane.galenos.2021.40427","DOIUrl":"https://doi.org/10.4274/gulhane.galenos.2021.40427","url":null,"abstract":"","PeriodicalId":35658,"journal":{"name":"Gulhane Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48866500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-07DOI: 10.4274/gulhane.galenos.2022.59454
Z. Düzgün, M. Cıncık, Yaprak Dönmez Çakıl, Şenay Kanaat, B. Selam
{"title":"The impact of oocyte denudation without a pre-incubation on intracytoplasmic sperm injection outcomes","authors":"Z. Düzgün, M. Cıncık, Yaprak Dönmez Çakıl, Şenay Kanaat, B. Selam","doi":"10.4274/gulhane.galenos.2022.59454","DOIUrl":"https://doi.org/10.4274/gulhane.galenos.2022.59454","url":null,"abstract":"","PeriodicalId":35658,"journal":{"name":"Gulhane Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49562572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-07DOI: 10.4274/gulhane.galenos.2022.96729-reply
Seyhan Demir Karabulut
{"title":"Reply to: Comment on “Parents’ and healthcare professionals’ views and attitudes toward anti-vaccination”","authors":"Seyhan Demir Karabulut","doi":"10.4274/gulhane.galenos.2022.96729-reply","DOIUrl":"https://doi.org/10.4274/gulhane.galenos.2022.96729-reply","url":null,"abstract":"","PeriodicalId":35658,"journal":{"name":"Gulhane Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45063960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-07DOI: 10.4274/gulhane.galenos.2022.92905
M. Aykan, İ. Ertürk, R. Acar, G. Keskin, Ece Örnek, N. Karadurmuş
{"title":"Efficacy of ifosfamide, carboplatin and etoposide chemotherapy protocol in relapsed refractory germ cell tumors","authors":"M. Aykan, İ. Ertürk, R. Acar, G. Keskin, Ece Örnek, N. Karadurmuş","doi":"10.4274/gulhane.galenos.2022.92905","DOIUrl":"https://doi.org/10.4274/gulhane.galenos.2022.92905","url":null,"abstract":"","PeriodicalId":35658,"journal":{"name":"Gulhane Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41835341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-07DOI: 10.4274/gulhane.galenos.2021.25733
M. Ramezani, Houshang Nemati, F. Najafi, B. Sayad, M. Sadeghi
We assessed the blood levels of the most important factors such as cytokines/chemokines in Coronavirus disease-2019 (COVID-19). PubMed/Medline and Scopus as two important databases were searched up to March 26, 2020. To analyze the data, we used Review Manager 5.3 software. Out of forty-two records retrieved from two databases, 10 studies were involved in the analysis. Thirty-three cytokines/chemokines were checked. The levels of 27 cytokines/chemokines in COVID-19 patients were higher than the healthy controls, and among 20 cytokines/chemokines;the levels of 10 cytokines/chemokines in severe COVID-19 patients were higher than non-severe COVID-19 patients. Also, out of three cytokines, one had a higher level in the intensive care unit (ICU) patients compared to the non-ICU patients. The findings showed the cytokine storm syndrome in COVID-19 patients, especially in patients with severe disease.
{"title":"A systematic review and meta-analysis on blood levels of cytokines/chemokines in COVID-19 cases","authors":"M. Ramezani, Houshang Nemati, F. Najafi, B. Sayad, M. Sadeghi","doi":"10.4274/gulhane.galenos.2021.25733","DOIUrl":"https://doi.org/10.4274/gulhane.galenos.2021.25733","url":null,"abstract":"We assessed the blood levels of the most important factors such as cytokines/chemokines in Coronavirus disease-2019 (COVID-19). PubMed/Medline and Scopus as two important databases were searched up to March 26, 2020. To analyze the data, we used Review Manager 5.3 software. Out of forty-two records retrieved from two databases, 10 studies were involved in the analysis. Thirty-three cytokines/chemokines were checked. The levels of 27 cytokines/chemokines in COVID-19 patients were higher than the healthy controls, and among 20 cytokines/chemokines;the levels of 10 cytokines/chemokines in severe COVID-19 patients were higher than non-severe COVID-19 patients. Also, out of three cytokines, one had a higher level in the intensive care unit (ICU) patients compared to the non-ICU patients. The findings showed the cytokine storm syndrome in COVID-19 patients, especially in patients with severe disease.","PeriodicalId":35658,"journal":{"name":"Gulhane Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46056298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-07DOI: 10.4274/gulhane.galenos.2021.85057
Ayşe Keleş, O. Yılmaz, Özge Yücel Çelik, G. Dağdeviren, Gülşah Aynaoğlu Yıldız, A. Yücel, D. Şahın
examined. Pregnancy outcomes and neonatal survival rates were evaluated. Results: A total of 396 congenital heart diseases were examined. CTA was diagnosed in 102 (25.8%) of the patients. Ninety-nine patients with available data were analyzed. A total of 33 (33.3%) patients were diagnosed with TOF, 30 (30.3%) with DORV, 16 (16.2%) with TA, 16 (16.2%) with TGA, and 4 (4%) with IIA-B. CTA was an isolated anomaly in 28 (28.3%) of the patients. The other patients had one or more accompanying cardiac/extracardiac anomalies. The prenatal invasive diagnostic was examined in 40 (40.4%) of the patients, and chromosomal anomalies were detected in 16 (40%) of them. In 18 (18.4%) of the patients, pregnancy was terminated at the request of the parents. Intrauterine demise occurred in 4 (4.9%) pregnancies that were not terminated, and neonatal death occurred in 26 (32.1%) of the newborns. Conclusions: The presence of additional cardiac, extracardiac, and genetic abnormalities are common in CTAs and are associated with adverse outcomes.
{"title":"Characteristics of fetal conotruncal heart anomalies","authors":"Ayşe Keleş, O. Yılmaz, Özge Yücel Çelik, G. Dağdeviren, Gülşah Aynaoğlu Yıldız, A. Yücel, D. Şahın","doi":"10.4274/gulhane.galenos.2021.85057","DOIUrl":"https://doi.org/10.4274/gulhane.galenos.2021.85057","url":null,"abstract":"examined. Pregnancy outcomes and neonatal survival rates were evaluated. Results: A total of 396 congenital heart diseases were examined. CTA was diagnosed in 102 (25.8%) of the patients. Ninety-nine patients with available data were analyzed. A total of 33 (33.3%) patients were diagnosed with TOF, 30 (30.3%) with DORV, 16 (16.2%) with TA, 16 (16.2%) with TGA, and 4 (4%) with IIA-B. CTA was an isolated anomaly in 28 (28.3%) of the patients. The other patients had one or more accompanying cardiac/extracardiac anomalies. The prenatal invasive diagnostic was examined in 40 (40.4%) of the patients, and chromosomal anomalies were detected in 16 (40%) of them. In 18 (18.4%) of the patients, pregnancy was terminated at the request of the parents. Intrauterine demise occurred in 4 (4.9%) pregnancies that were not terminated, and neonatal death occurred in 26 (32.1%) of the newborns. Conclusions: The presence of additional cardiac, extracardiac, and genetic abnormalities are common in CTAs and are associated with adverse outcomes.","PeriodicalId":35658,"journal":{"name":"Gulhane Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41571322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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