Tetsuro Shimakami, R. Sakuma, K. Kawana, Kaoru Ohchi, S. Mochida, H. Kumada
{"title":"A Post-marketing surveillance of ombitasvir/paritaprevir/ritonavir for patients with hepatitis C virus genotype 1b infection: A follow-up study of phase 2 and 3 clinical trials","authors":"Tetsuro Shimakami, R. Sakuma, K. Kawana, Kaoru Ohchi, S. Mochida, H. Kumada","doi":"10.2957/kanzo.63.319","DOIUrl":"https://doi.org/10.2957/kanzo.63.319","url":null,"abstract":"","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43437948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Utako Kitazawa, H. Maruyama, Hiroo Fukada, Maki Morinaga, Eisuke Nakadera, A. Uchiyama, R. Yaginuma, K. Fukuhara, Kazuyoshi Kon, S. Yamashina, Maki Tobari, H. Nagamatsu, H. Isayama, K. Ikejima, A. Nagahara, S. Shiina
{"title":"A case of aneurysm in the splenorenal collateral treated by BRTO with GERTO in a patient on maintenance dialysis accompanied by alcoholic liver fibrosis","authors":"Utako Kitazawa, H. Maruyama, Hiroo Fukada, Maki Morinaga, Eisuke Nakadera, A. Uchiyama, R. Yaginuma, K. Fukuhara, Kazuyoshi Kon, S. Yamashina, Maki Tobari, H. Nagamatsu, H. Isayama, K. Ikejima, A. Nagahara, S. Shiina","doi":"10.2957/kanzo.63.286","DOIUrl":"https://doi.org/10.2957/kanzo.63.286","url":null,"abstract":"","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42543798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hideki Fujii, Satoshi Tanaka, Ryoko Yamada, T. Nomura, Y. Eso, T. Ishii, H. Iijima
{"title":"Results of a survey of the Japan Society of Hepatology members -285 responses on academic, household, and social networking-","authors":"Hideki Fujii, Satoshi Tanaka, Ryoko Yamada, T. Nomura, Y. Eso, T. Ishii, H. Iijima","doi":"10.2957/kanzo.63.259","DOIUrl":"https://doi.org/10.2957/kanzo.63.259","url":null,"abstract":"","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45106576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eiichiro Yasutomi, Y. Yano, A. Yamamoto, Jun Kitadai, Naoki Asaji, Ryutaro Yoshida, Yuri Hatazawa, Takanori Matsuura, Y. Shiomi, Y. Ueda, Y. Kodama
{"title":"Cerebral hemorrhage during systemic chemotherapy with atezolizumab and bevacizumab for hepatocellular carcinoma","authors":"Eiichiro Yasutomi, Y. Yano, A. Yamamoto, Jun Kitadai, Naoki Asaji, Ryutaro Yoshida, Yuri Hatazawa, Takanori Matsuura, Y. Shiomi, Y. Ueda, Y. Kodama","doi":"10.2957/kanzo.63.297","DOIUrl":"https://doi.org/10.2957/kanzo.63.297","url":null,"abstract":"","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48584601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ryoichi Miura, M. Imamura, K. Amioka, Kenichiro Kodama, S. Uchikawa, H. Fujino, Atsushi Ohno, T. Nakahara, E. Murakami, M. Yamauchi, T. Kawaoka, Aya Kido, K. Sentani, N. Oue, K. Arihiro, H. Aikata
{"title":"A patient with polycystic liver disease combined with portal hypertension that died due to bacterial peritonitis as a secondary cause of death","authors":"Ryoichi Miura, M. Imamura, K. Amioka, Kenichiro Kodama, S. Uchikawa, H. Fujino, Atsushi Ohno, T. Nakahara, E. Murakami, M. Yamauchi, T. Kawaoka, Aya Kido, K. Sentani, N. Oue, K. Arihiro, H. Aikata","doi":"10.2957/kanzo.63.279","DOIUrl":"https://doi.org/10.2957/kanzo.63.279","url":null,"abstract":"","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43258307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yutaka Matsuzaki, Hitomi Fujimoto, Shota Adachi, Koshi Matsumoto, Sumika Oyama, Hiromi Saito, Y. Saijo, K. Azuhata, N. Ito, Toru Igarashi, N. Arakura, S. Usuda, K. Kiyosawa
{"title":"A male case of acute onset antimitochondrial-M2 antibody-positive autoimmune hepatitis after pulmonary thromboembolism: A case report","authors":"Yutaka Matsuzaki, Hitomi Fujimoto, Shota Adachi, Koshi Matsumoto, Sumika Oyama, Hiromi Saito, Y. Saijo, K. Azuhata, N. Ito, Toru Igarashi, N. Arakura, S. Usuda, K. Kiyosawa","doi":"10.2957/kanzo.63.246","DOIUrl":"https://doi.org/10.2957/kanzo.63.246","url":null,"abstract":"","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48100847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kumichika Uchida, T. Aoyama, Yuji Terai, Naomi Yamaguchi, S. Kato, K. Yakabi, Jun Kikuchi, S. Ogasawara, H. Yano, S. Nagoshi
Lenvatinib was prescribed to a 71-year-old man with hepatocellular carcinoma (210mm, largest dimension) and portal vein tumor thrombosis. However, this treatment was discontinued 8 days later due to prolongation of prothrombin time and an increase in AST and LDH levels. Rupture of the hepatocellular carcinoma occurred 4 days after discontinuing Lenvatinib and the patient died. Autopsy findings showed a moderately differenti-ated hepatocellular carcinoma with diffuse hemorrhagic necrosis. Immunohistochemistry revealed diffuse FGF 19 protein expression in the nuclei of tumor cells, whereas some of the nuclei and cytoplasm of the hepatocytes in non-tumorous tissue were only slightly stained. The risk of hepatocellular carcinoma rupture should always be considered even after stopping short-term chemotherapy with Lenvatinib.
{"title":"Ruptured hepatocellular carcinoma following administration of Lenvatinib: an autopsy case","authors":"Kumichika Uchida, T. Aoyama, Yuji Terai, Naomi Yamaguchi, S. Kato, K. Yakabi, Jun Kikuchi, S. Ogasawara, H. Yano, S. Nagoshi","doi":"10.2957/kanzo.63.238","DOIUrl":"https://doi.org/10.2957/kanzo.63.238","url":null,"abstract":"Lenvatinib was prescribed to a 71-year-old man with hepatocellular carcinoma (210mm, largest dimension) and portal vein tumor thrombosis. However, this treatment was discontinued 8 days later due to prolongation of prothrombin time and an increase in AST and LDH levels. Rupture of the hepatocellular carcinoma occurred 4 days after discontinuing Lenvatinib and the patient died. Autopsy findings showed a moderately differenti-ated hepatocellular carcinoma with diffuse hemorrhagic necrosis. Immunohistochemistry revealed diffuse FGF 19 protein expression in the nuclei of tumor cells, whereas some of the nuclei and cytoplasm of the hepatocytes in non-tumorous tissue were only slightly stained. The risk of hepatocellular carcinoma rupture should always be considered even after stopping short-term chemotherapy with Lenvatinib.","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45073558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Fujioka, K. Kikuchi, Kotaro Matsumoto, Sho Ohyatsu, Tomoyuki Nariyama, T. Kohyama, Minoru Yoshida, Y. Moritoki, M. Hara
In our hospital, the Infection Control Team (ICT) evaluates patients who test positive for the hepatitis virus during preoperative and preadmission tests (the hepatitis virus round), and adds referral requests to a hepatolo-gist to the electronic medical records of these patients. A review after 1 year of this practice confirmed that number of referrals provided by non-hepatology specialty physicians was low, especially among short-stay inpa-tients. Therefore, we requested referrals using the nudge method in year 2 of the initial infection control train-ing session. This increased the referral consultation rate for short-term hospitalization from 14.3% (3/21) before ICT referral to 31.6% (6/19) in the 1 st year and 66.7% (8/12) in the 2 nd year (vs. before the start, p ＜ 0.01). Thus, the nudge method is effective in promoting voluntary behavior change and can increase rates of referred consulta-tions.
{"title":"Using the nudge method to promote referrals of HBs antigen-/HCV antibody-positive patients from non-hepatology specialty physicians","authors":"H. Fujioka, K. Kikuchi, Kotaro Matsumoto, Sho Ohyatsu, Tomoyuki Nariyama, T. Kohyama, Minoru Yoshida, Y. Moritoki, M. Hara","doi":"10.2957/kanzo.63.224","DOIUrl":"https://doi.org/10.2957/kanzo.63.224","url":null,"abstract":"In our hospital, the Infection Control Team (ICT) evaluates patients who test positive for the hepatitis virus during preoperative and preadmission tests (the hepatitis virus round), and adds referral requests to a hepatolo-gist to the electronic medical records of these patients. A review after 1 year of this practice confirmed that number of referrals provided by non-hepatology specialty physicians was low, especially among short-stay inpa-tients. Therefore, we requested referrals using the nudge method in year 2 of the initial infection control train-ing session. This increased the referral consultation rate for short-term hospitalization from 14.3% (3/21) before ICT referral to 31.6% (6/19) in the 1 st year and 66.7% (8/12) in the 2 nd year (vs. before the start, p ＜ 0.01). Thus, the nudge method is effective in promoting voluntary behavior change and can increase rates of referred consulta-tions.","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48588703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Kaizuka, K. Sugimoto, M. Abe, Yu Yoshimasu, Hirohito Takeuchi, Yoshitaka Kasai, N. Shirota, T. Saguchi, H. Yamaguchi, T. Itoi
A 20-year-old man was referred to pediatrics for hyperbilirubinemia and mental retardation. Abdominal ultrasonography findings were indicative of a portosystemic shunt, and as a shunt between the left branch of the portal vein and inferior vena cava was confirmed by abdominal computed tomography, he was diagnosed with patency of the venous duct. We decided to perform shunt embolization using IVR, but as the shunt diame-ter had expanded like a funnel, its embolization was performed using a plug-and -metal coil, which led to an im-provement in hepatic reserve and blood ammonia levels postprocedure. Surgical ligation has been typically used in the management of portosystemic shunts, but as it is highly invasive, shunt embolization by IVR has become prevalent in recent years. Here we describe stable embolization using the IVR technique.
{"title":"Successful management of a congenital portosystemic shunt using coil-in-plug embolization: A case report","authors":"H. Kaizuka, K. Sugimoto, M. Abe, Yu Yoshimasu, Hirohito Takeuchi, Yoshitaka Kasai, N. Shirota, T. Saguchi, H. Yamaguchi, T. Itoi","doi":"10.2957/kanzo.63.232","DOIUrl":"https://doi.org/10.2957/kanzo.63.232","url":null,"abstract":"A 20-year-old man was referred to pediatrics for hyperbilirubinemia and mental retardation. Abdominal ultrasonography findings were indicative of a portosystemic shunt, and as a shunt between the left branch of the portal vein and inferior vena cava was confirmed by abdominal computed tomography, he was diagnosed with patency of the venous duct. We decided to perform shunt embolization using IVR, but as the shunt diame-ter had expanded like a funnel, its embolization was performed using a plug-and -metal coil, which led to an im-provement in hepatic reserve and blood ammonia levels postprocedure. Surgical ligation has been typically used in the management of portosystemic shunts, but as it is highly invasive, shunt embolization by IVR has become prevalent in recent years. Here we describe stable embolization using the IVR technique.","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48838909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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