K. Kuramitsu, T. Kogiso, R. Itoh, A. Takai, Yoko Yoshimaru, M. Ishigami, Po-sung Chu, A. Takaki, Shohei Narita, Shunji Watanabe, Keisuke Kakisaka, Tomoharu Yamada, K. Maesaka, K. Ogawa, H. Egawa
{"title":"Present Status of Transplant Hepatologist in Japan","authors":"K. Kuramitsu, T. Kogiso, R. Itoh, A. Takai, Yoko Yoshimaru, M. Ishigami, Po-sung Chu, A. Takaki, Shohei Narita, Shunji Watanabe, Keisuke Kakisaka, Tomoharu Yamada, K. Maesaka, K. Ogawa, H. Egawa","doi":"10.2957/kanzo.62.785","DOIUrl":"https://doi.org/10.2957/kanzo.62.785","url":null,"abstract":"","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41711946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nana Yazawa, Takayuki Shimizu, Y. Sakuraoka, Y. Iso, T. Aoki, Mariko Kumazawa, K. Ishihara, Y. Shioyama, A. Irisawa, K. Kubota
We report a case of huge portosystemic shunt treated by balloon-occluded retrograde transvenous obliteration (BRTO). The patient was a 67-year-old female with liver cirrhosis, a huge portal-systemic shunt, hy-perammonemia, and thrombocytopenia. BRTO was performed because hepatic encephalopathy was suspected. The preoperative liver function was Child-Pugh class A, whereas the wedged hepatic venous pressure was 19 mmHg. Six months postoperatively, she had liver failure because of a gastroesophageal varix rupture. This case suggests that cases of BRTO for a huge shunt should be carefully considered in patients with liver cirrhosis.
{"title":"Liver failure after huge portosystemic shunt occlusion by balloon-occluded retrograde transvenous obliteration: A case report","authors":"Nana Yazawa, Takayuki Shimizu, Y. Sakuraoka, Y. Iso, T. Aoki, Mariko Kumazawa, K. Ishihara, Y. Shioyama, A. Irisawa, K. Kubota","doi":"10.2957/kanzo.62.800","DOIUrl":"https://doi.org/10.2957/kanzo.62.800","url":null,"abstract":"We report a case of huge portosystemic shunt treated by balloon-occluded retrograde transvenous obliteration (BRTO). The patient was a 67-year-old female with liver cirrhosis, a huge portal-systemic shunt, hy-perammonemia, and thrombocytopenia. BRTO was performed because hepatic encephalopathy was suspected. The preoperative liver function was Child-Pugh class A, whereas the wedged hepatic venous pressure was 19 mmHg. Six months postoperatively, she had liver failure because of a gastroesophageal varix rupture. This case suggests that cases of BRTO for a huge shunt should be carefully considered in patients with liver cirrhosis.","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41850255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kenji Urakabe, T. Mizushima, Hironobu Tsukamoto, Yasuaki Fujita, K. Haneda, Yuta Suzuki, A. Minowa, R. Ishihara, Yusuke Kito, Kazuko Watanabe, Fumihiro Okumura
{"title":"Two cases of steroid-resistant nivolumab-induced sclerosing cholangitis","authors":"Kenji Urakabe, T. Mizushima, Hironobu Tsukamoto, Yasuaki Fujita, K. Haneda, Yuta Suzuki, A. Minowa, R. Ishihara, Yusuke Kito, Kazuko Watanabe, Fumihiro Okumura","doi":"10.2957/kanzo.62.712","DOIUrl":"https://doi.org/10.2957/kanzo.62.712","url":null,"abstract":"","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47248014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hironori Nakamura, T. Hanai, Takahisa Mizukusa, H. Hatakeyama, S. Nishiwaki
{"title":"A case of severe hypothyroidism followed by transcatheter arterial chemoembolization with miriplatin-lipiodol suspension for the treatment of hepatocellular carcinoma","authors":"Hironori Nakamura, T. Hanai, Takahisa Mizukusa, H. Hatakeyama, S. Nishiwaki","doi":"10.2957/kanzo.62.756","DOIUrl":"https://doi.org/10.2957/kanzo.62.756","url":null,"abstract":"","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47196552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Mochida, R. Sakuma, R. Nakajima, T. Kawaberi, N. Izumi
{"title":"Drug use-results survey of ombitasvir/paritaprevir/ritonavir coformulated tablet in patients with genotype 1 chronic hepatitis C with or without compensated cirrhosis","authors":"S. Mochida, R. Sakuma, R. Nakajima, T. Kawaberi, N. Izumi","doi":"10.2957/kanzo.62.690","DOIUrl":"https://doi.org/10.2957/kanzo.62.690","url":null,"abstract":"","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46860909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Takakusagi, Kana Inoue, Tomomi Takahashi, T. Kosone, H. Takagi
In total, 428 cases of chronic hepatitis C were treated by direct acting antivirals, and 400 cases achieved a sustained viral response (SVR) (93.5%). We were able to contact 20 cases of SVR in the 44 dropped-out cases from the routine screening of hepatocellular carcinoma (HCC), and the hepatitis medical care coordinators (HMCCs) noticed the need for HCC screening even after achieving SVR. HMCCs in Japan, usually nurses and other medical staff such as medical clerks, should be educated regarding the prevention and examination of hepatitis virus infection. They would be available to consult for hepatitis, its treatment and follow-up for the development of HCC even after achieving SVR. In our study, 3 HCC cases were found from 20 patients who achieved SVR with-out follow-up HCC screening. They were successfully treated and demonstrated a complete remission. Thus, SVR cases of chronic hepatitis C must be recognized as having a risk for HCC development, and HMCCs play a significant role in the surveillance of such patients.
{"title":"Importance of HCC surveillance among patients with hepatitis C who have achieved a sustained viral response but have dropped out of periodical follow up","authors":"S. Takakusagi, Kana Inoue, Tomomi Takahashi, T. Kosone, H. Takagi","doi":"10.2957/kanzo.62.703","DOIUrl":"https://doi.org/10.2957/kanzo.62.703","url":null,"abstract":"In total, 428 cases of chronic hepatitis C were treated by direct acting antivirals, and 400 cases achieved a sustained viral response (SVR) (93.5%). We were able to contact 20 cases of SVR in the 44 dropped-out cases from the routine screening of hepatocellular carcinoma (HCC), and the hepatitis medical care coordinators (HMCCs) noticed the need for HCC screening even after achieving SVR. HMCCs in Japan, usually nurses and other medical staff such as medical clerks, should be educated regarding the prevention and examination of hepatitis virus infection. They would be available to consult for hepatitis, its treatment and follow-up for the development of HCC even after achieving SVR. In our study, 3 HCC cases were found from 20 patients who achieved SVR with-out follow-up HCC screening. They were successfully treated and demonstrated a complete remission. Thus, SVR cases of chronic hepatitis C must be recognized as having a risk for HCC development, and HMCCs play a significant role in the surveillance of such patients.","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46017678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maho Okada, Yuga Amano, T. Nakai, Yasuko Kawasaki, G. Hamano, Shintaro Koudai, S. Shimizu, A. Kanazawa, H. Fukushima, Takeshi Inoue, K. Kioka
{"title":"A case of lymphoepithelioma-like carcinoma in the liver diagnosed via laparoscopic liver tumor resection","authors":"Maho Okada, Yuga Amano, T. Nakai, Yasuko Kawasaki, G. Hamano, Shintaro Koudai, S. Shimizu, A. Kanazawa, H. Fukushima, Takeshi Inoue, K. Kioka","doi":"10.2957/kanzo.62.724","DOIUrl":"https://doi.org/10.2957/kanzo.62.724","url":null,"abstract":"","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44936361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Ono, A. Hashimoto, Takamitsu Tanaka, H. Fuke, A. Shimizu, M. Kakeda, H. Nakano
The patient was a woman in her 40s who was working at a brothel. She came to our hospital with a chief complaint of a vulvar mass. We suspected syphilis based on the cutaneous findings and a positive RPR test. Se-rum hepatobiliary enzymes were elevated, and biliary tract enzymes were significantly high. Abdominal imaging showed fatty changes around the portal veins and diffuse intrahepatic biliary strictures. Liver biopsy showed lymphocytic infiltration and fibrosis around the Glissonʼs sheath and fatty degeneration in the paren-chyma. After prescribing AMPC, the blood test and imaging findings improved over the course of approxi-mately 11 months. Among the past reports of early syphilitic hepatitis, only a few have shown biliary abnormali-ties on imaging. In contrast, our case demonstrated characteristic bile duct imaging findings that were consis-tent with the features of early syphilitic hepatitis, which mainly affects the biliary system.
{"title":"Early syphilitic hepatitis with diffuse intrahepatic biliary strictures: A case report","authors":"T. Ono, A. Hashimoto, Takamitsu Tanaka, H. Fuke, A. Shimizu, M. Kakeda, H. Nakano","doi":"10.2957/kanzo.62.734","DOIUrl":"https://doi.org/10.2957/kanzo.62.734","url":null,"abstract":"The patient was a woman in her 40s who was working at a brothel. She came to our hospital with a chief complaint of a vulvar mass. We suspected syphilis based on the cutaneous findings and a positive RPR test. Se-rum hepatobiliary enzymes were elevated, and biliary tract enzymes were significantly high. Abdominal imaging showed fatty changes around the portal veins and diffuse intrahepatic biliary strictures. Liver biopsy showed lymphocytic infiltration and fibrosis around the Glissonʼs sheath and fatty degeneration in the paren-chyma. After prescribing AMPC, the blood test and imaging findings improved over the course of approxi-mately 11 months. Among the past reports of early syphilitic hepatitis, only a few have shown biliary abnormali-ties on imaging. In contrast, our case demonstrated characteristic bile duct imaging findings that were consis-tent with the features of early syphilitic hepatitis, which mainly affects the biliary system.","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48055029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Issues regarding NAFLD~From the changes and problems in the pathological diagnosis of NASH to the confusion of nomenclature change","authors":"T. Kodama, K. Kozumi, T. Takehara","doi":"10.2957/kanzo.62.681","DOIUrl":"https://doi.org/10.2957/kanzo.62.681","url":null,"abstract":"要旨:世界人口の約 3割が罹患している NAFLDの中から,病勢進行が生じる NASHや生命予 後と直結する線維化進展例を同定することは臨床上重要である.NASHの診断には侵襲的な肝 生検が必要であるが,病理学的な診断のばらつきが問題である.NASHの確立された治療法は 未だ存在しないが,病理学的な評価が臨床試験のエンドポイントに用いられてきたことはその一 因と考えられる.そこで国際的な取り組みとして,NASHの病理診断や活動性評価基準の統一 化,診療ガイドラインの策定,臨床試験における適切なサロゲートマーカーの検討,そして肝生 検に代わる非侵襲的バイオマーカーの開発が行われてきた.我々も最近 NASH・肝線維化診断 やNAFLD予後予測に有用な血清マーカーを報告した.また,脂肪性肝疾患を広く含有したNAFLD に代わる新名称としてMAFLDが近年提唱されたが,世界的なコンセンサスは未だ得られてい ない. 索引用語: NAFLD NASH TSP-2 MAFLD バイオマーカー","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48683094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Kim, T. Fujii, S. Kim, Hisato Kobayashi, T. Okuda, T. Hayakumo, Yumi Fujii, A. Nakai, A. Ohtani, Ketherine Kim, O. Nakashima, T. Kumabe, M. Sasaki, Y. Koma, S. Kubo, H. Yasui, T. Matsushita, Hironori Tanaka, A. Yamada
{"title":"Radiological and histopathological analyses of two bile duct adenoma cases focused on washout in the portal phase of contrast-enhanced ultrasound","authors":"S. Kim, T. Fujii, S. Kim, Hisato Kobayashi, T. Okuda, T. Hayakumo, Yumi Fujii, A. Nakai, A. Ohtani, Ketherine Kim, O. Nakashima, T. Kumabe, M. Sasaki, Y. Koma, S. Kubo, H. Yasui, T. Matsushita, Hironori Tanaka, A. Yamada","doi":"10.2957/kanzo.62.765","DOIUrl":"https://doi.org/10.2957/kanzo.62.765","url":null,"abstract":"","PeriodicalId":35810,"journal":{"name":"Acta Hepatologica Japonica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44794679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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