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Influence of Inula helenium rhizomes and Matricaria chamomilla inflorescences on the biochemical and physiological parameters in male rats fed a high-fat diet. 茵陈根茎和洋甘菊花序对高脂饮食雄性大鼠生化和生理参数的影响
Q2 Medicine Pub Date : 2023-01-01 DOI: 10.32394/rpzh.2023.0281
Maryna Lieshchova, Valentyn Yefimov, Victor Brygadyrenko

Background: Pharmacological correction of a high-fat diet is of great interest to prevent the development of obesity and hypertension. More and more research is being done on the preventive use of medicinal herbs for excess caloric intake.

Objective: The aim of this study was to determine the general physiological effect of I. helenium rhizomes and M. chamomilla inflorescences used in the diet of male rats consuming excess amounts of fat and calories in the daily diet.

Material and methods: In a 30-day experiment, we determined the effect of I. helenium rhizome and M. chamomilla on the physiological activity and metabolic processes of laboratory rats consuming a high-fat diet. The physical activity was evaluated according to the mass gain of animals and change in the relative mass of the internal organs, and also the functional conditions of the central nervous system. The influence on the metabolic processes was revealed by biochemical and clinical blood analyses.

Results: In a laboratory experiment on male rats, it was found that the addition of dry crushed rhizomes of Inula helenium L. and inflorescences of Matricaria chamomilla L. to the diet caused opposite changes in body weight. In the control group, the animals slightly increased their body weight (up to 111.5% of the initial weight by the end of the experiment); the rhizomes of I. helenium caused a decrease in body weight gain (up to 105.5% on the 30th day of the experiment compared to the initial weight); rats fed M. chamomilla inflorescences gained 123.2% of their initial body weight during the month of the experiment. The rhizomes of I. helenium caused an increase in the stomach relative mass. A decrease in the thymus relative weight was observed when animals were fed M. chamomilla inflorescences. The rhizomes of I. helenium stimulated an increase of blood protein concentration (mainly due to globulins), an increase in the alkaline phosphatase activity and cholesterol, and a decrease in the triglycerides concentration. M. chamomilla inflorescences reduced the blood urea concentration and increased the activity of alkaline phosphatase, causing strong changes in fat metabolism. Under the influence of the diet with the addition of M. chamomilla inflorescences, the atherogenic index increased in animals by 6.5 times relatively to the control group (due to a decrease in the concentration of high-density lipoprotein cholesterol and an increase in the concentration of low-density lipoprotein cholesterol, an increase in the total cholesterol concentration). When M. chamomilla was added to the diet, the blood triglycerides concentration in animals decreased sharply and the concentration of leukocytes increased. The concentration of monocytes exceeded the limits of the physiological norm both in the control group and in the group of animals fed on M. chamomilla inflorescences.

Conclusions:

背景:用药物纠正高脂肪饮食对预防肥胖症和高血压的发生具有重要意义。目前,越来越多的研究正在进行中草药预防热量摄入过多的研究:本研究的目的是确定在日常饮食中摄入过量脂肪和热量的雄性大鼠饮食中使用的鹤顶红根茎和洋甘菊花序的一般生理效应:在为期 30 天的实验中,我们测定了鹤顶红根茎和洋甘菊对摄入高脂肪饮食的实验鼠的生理活动和新陈代谢过程的影响。根据动物的体重增加、内脏器官相对质量的变化以及中枢神经系统的功能状况,对大鼠的生理活动进行了评估。生化和临床血液分析表明了运动对新陈代谢过程的影响:在对雄性大鼠进行的实验室实验中发现,在饮食中添加干碎的茵陈根茎和母菊花序会导致体重发生相反的变化。在对照组中,动物的体重略有增加(在实验结束时达到初始体重的 111.5%);茵陈根茎导致体重增加减少(在实验的第 30 天达到初始体重的 105.5%);喂食洋甘菊花序的大鼠在实验的一个月中增加了初始体重的 123.2%。I. helenium的根茎会增加胃的相对质量。给动物喂食洋甘菊花序时,胸腺相对重量有所减少。鹤望兰根茎会刺激血液中蛋白质浓度的增加(主要是球蛋白)、碱性磷酸酶活性和胆固醇的增加以及甘油三酯浓度的降低。洋甘菊花序降低了血液中的尿素浓度,提高了碱性磷酸酶的活性,导致脂肪代谢发生强烈变化。在添加了洋甘菊花序的饮食影响下,动物的动脉粥样硬化指数比对照组增加了 6.5 倍(原因是高密度脂蛋白胆固醇浓度降低,低密度脂蛋白胆固醇浓度增加,总胆固醇浓度增加)。在饮食中添加洋甘菊后,动物血液中的甘油三酯浓度急剧下降,白细胞浓度上升。在对照组和以洋甘菊花序喂养的动物组中,单核细胞的浓度都超过了生理正常值:研究结果表明,有望进一步研究鹤顶红根茎在预防高血压方面的作用,同时也表明,在高脂肪和高热量饮食期间,将洋甘菊花序用于预防目的存在很大风险。
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引用次数: 0
Prevalence and predictors of depression, anxiety, and stress among recovered COVID-19 patients in Vietnam. 越南COVID-19康复患者抑郁、焦虑和压力的患病率及预测因素
Q2 Medicine Pub Date : 2023-01-01 DOI: 10.32394/rpzh.2023.0261
Le Thanh Thao Trang, Cua Ngoc Le, Nirachon Chutipatana, Shamarina Shohaimi, Charuai Suwanbamrung

Background: During the COVID-19 pandemic, a high prevalence of mental health distress has been reported among people who have recovered from the disease.

Objectives: To assess the prevalence of depression, anxiety, and stress as well as identify predictors among recovered COVID-19 patients after more than six months of being discharged in Dong Thap Province, Vietnam.

Material and methods: The cross-sectional study was conducted among 549 eligible participants recruited by stratified sampling. Data was collected using the depression, anxiety and stress scale - 21 items had Content Validity Index = 0.9, and Cronbach's alpha for depression, anxiety and stress sub-scales were 0.95, 0.81, and 0.86, respectively. Descriptive statistics were used to measure the prevalence levels and distribution of characteristics of the participant, while factors influencing depression, anxiety, and stress were predicted using binary logistic regression.

Results: The overall prevalence of depression, anxiety, and stress were 24.8% (95% CI: 21.2-28.6), 41.5% (95% CI: 37.4-45.8), and 25.3% (95% CI: 21.7-29.2), respectively. The predictors of depression were living in urban area (OR = 1.97; 95% CI: 1.27-3.08), holding a bachelor's degree (OR:3.51; 95% CI: 1.13-10.8), having a high monthly income (OR: 2.57; 95% CI: 1.03-6.38), diabetes (OR: 2.21; 95% CI: 1.04-4.68), heart disease (OR: 3.83; 95% CI: 1.79-8.17), respiratory disease (OR: 3.49; 95% CI: 1.24-9.84), and diarrhea (OR: 4.07; 95% CI: 1.06-15.6). Living in the urban area (OR: 1.57; 95% CI: 1.07-2.29), having sleep disturbance (OR: 2.32; 95% CI: 1.56-3.46), and fatigue (OR: 1.57; 95% CI: 1.03-2.39) were predictors for anxiety. Having respiratory disease (OR: 3.75; 95% CI: 1.47-9.60) or diarrhea (OR: 4.34; 95% CI: 1.18-15.9) were predictors of stress.

Conclusion: People who have recovered from COVID-19 should be assessed for symptoms of depression, anxiety, and stress. Primary healthcare providers should develop interventions to support their recovery.

背景:在2019冠状病毒病大流行期间,据报道,在疾病康复者中,精神健康困扰的发生率很高。目的:评估越南同塔省出院6个多月后康复的COVID-19患者抑郁、焦虑和压力的患病率,并确定预测因素。材料与方法:采用分层抽样方法,对549名符合条件的受试者进行横断面研究。采用抑郁、焦虑和压力量表收集数据,其中21个条目的内容效度指数为0.9,抑郁、焦虑和压力子量表的Cronbach's alpha分别为0.95、0.81和0.86。描述性统计用于测量参与者的患病率水平和特征分布,而影响抑郁、焦虑和压力的因素使用二元逻辑回归进行预测。结果:抑郁、焦虑和压力的总体患病率分别为24.8% (95% CI: 21.2-28.6)、41.5% (95% CI: 37.4-45.8)和25.3% (95% CI: 21.7-29.2)。预测抑郁的因素为居住在城市地区(OR = 1.97;95% CI: 1.27-3.08),持有学士学位(OR:3.51;95% CI: 1.13-10.8),月收入高(OR: 2.57;95% CI: 1.03-6.38),糖尿病(OR: 2.21;95% CI: 1.04-4.68),心脏病(OR: 3.83;95% CI: 1.79-8.17),呼吸系统疾病(OR: 3.49;95% CI: 1.24-9.84)和腹泻(OR: 4.07;95% ci: 1.06-15.6)。居住在市区(OR: 1.57;95% CI: 1.07-2.29),有睡眠障碍(OR: 2.32;95% CI: 1.56-3.46)和疲劳(OR: 1.57;95% CI: 1.03-2.39)是焦虑的预测因子。患有呼吸道疾病(OR: 3.75;95% CI: 1.47-9.60)或腹泻(or: 4.34;95% CI: 1.18-15.9)是压力的预测因子。结论:应对COVID-19康复者进行抑郁、焦虑和压力症状评估。初级卫生保健提供者应制定干预措施以支持其康复。
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引用次数: 0
Benefits of sea buckthorn juice consumption in women of productive age with hypercholesterolemia. 食用沙棘汁对高胆固醇血症生育年龄妇女的益处。
Q2 Medicine Pub Date : 2023-01-01 DOI: 10.32394/rpzh.2023.0258
Jana Kopčeková, Jana Mrázová, Katarína Fatrcová-Šramková, Marta Habánová, Martina Gažarová, Petra Lenártová

Background: Sea buckthorn contains almost 200 nutrients and bioactive substances, including phenolic compounds such as flavonoids, vitamins, proteins, amino acids, minerals, alkaloids, chlorophyll derivatives, amines, organic acids, fatty acids and phytosterols. Human and animal studies suggest that sea buckthorn may have a variety of beneficial effects: cardioprotective, antiatherogenic, antioxidant, anticancer, immunomodulatory, antibacterial, antiviral and antiinflammatory.

Objective: The aim of this study was to evaluate the effect of regular consumption of 100% sea buckthorn juice on the risk factors of cardiovascular diseases in women of productive age with hypercholesterolemia.

Material and methods: A clinical study involved 19 women with a mean age of 54.06 ±2.97 years who consumed 50 mL of sea buckthorn juice daily for 8 weeks. Anthropometric and biochemical parameters in blood serum were monitored before the start of sea buckthorn consumption and after 8 weeks of consumption. Body composition was determined using an multifrequency analyzer InBody720. Routine biochemical analyzes were performed by standard methods in an accredited laboratory of the University Hospital by automatic biochemical analyzer BioMajesty JCA-BM6010/C. Statistical comparison between individual measurements was performed using a paired t-test, using Statistica Cz version 10 (TIBCO Software, Inc., Palo Alto, CA, USA).

Results: We observed significant decrease of body weight, body mass index (P<0.05), body fat and visceral fat (P<0.001) after 8 weeks of consumption of 100% sea buckthorn juice. In this intervention study, we observed a significant decrease in low-density cholesterol (P˂0.05) and a significant increase in high-density cholesterol (P˂0.001). The level of triglycerides was similar at the end of the study (P>0.05). After the intervention, we observed decrease of orosomucoid, immunoglobulin A, immunoglobulin G, immunoglobulin M (P<0.001) and C-reactive protein (P<0.01).

Conclusions: The obtained results support the hypothesis that the daily consumption of sea buckthorn juice for eight weeks could contribute to the beneficial effects of reducing the risk of cardiovascular diseases, such as the reduction of body and visceral fat, LDL-C, CRP and the increase of HDL-C.

背景:沙棘含有近200种营养物质和生物活性物质,包括类黄酮、维生素、蛋白质、氨基酸、矿物质、生物碱、叶绿素衍生物、胺、有机酸、脂肪酸和植物甾醇等酚类化合物。人体和动物研究表明,沙棘可能具有多种有益作用:保护心脏、抗动脉粥样硬化、抗氧化、抗癌、免疫调节、抗菌、抗病毒和抗炎。目的:本研究的目的是评估定期食用100%沙棘汁对育龄妇女高胆固醇血症心血管疾病危险因素的影响。材料与方法:19名平均年龄为54.06±2.97岁的女性,连续8周每天饮用50 mL沙棘汁。在沙棘开始进食前和进食8周后监测血清的人体测量和生化参数。使用InBody720多频分析仪测定体成分。常规生化分析在大学医院认可实验室采用BioMajesty JCA-BM6010/C全自动生化分析仪,按标准方法进行。使用Statistica Cz version 10 (TIBCO Software, Inc., Palo Alto, CA, USA),使用配对t检验进行个体测量之间的统计比较。结果:患者体重、体质指数明显下降(P0.05)。干预后,我们观察到orosomucoid,免疫球蛋白A,免疫球蛋白G,免疫球蛋白M (p)的降低。结论:我们得到的结果支持了假设,每天饮用沙棘汁8周可以降低体脂和内脏脂肪,降低LDL-C, CRP,升高HDL-C,有助于降低心血管疾病的风险。
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引用次数: 0
Impact of the COVID-19 pandemic on the changes in dietary habits, lifestyle and physical activity in the Slovak population. COVID-19大流行对斯洛伐克人口饮食习惯、生活方式和身体活动变化的影响
Q2 Medicine Pub Date : 2023-01-01 DOI: 10.32394/rpzh.2023.0268
Marta Lorková, Martina Gažarová

Background: The COVID-19 pandemic caused by the coronavirus was accompanied by the emergence of various adverse conditions, as well as the deterioration of health from the point of view of chronic diseases, as well as lifestyle changes related to the preference of certain foods and changes in body weight due to the restriction of free movement.

Objective: The objective of our survey was to assess the impact of the pandemic and lockdown on selected key lifestyle elements affecting the overall health status of the Slovak population and subsequently to evaluate subjectively assessed changes in the respondents' eating habits, daily routine, physical activity and body weight.

Material and methods: The research group consisted of 528 participants who took part in an online distributed questionnaire survey.

Results: Respondents subjectively evaluated the change in lifestyle rather negatively. Up to 48.37% of men and 38.93% of women reported a change for the worse. Almost 59% of participants reported no change in their health, while almost a quarter reported a slight deterioration in their health. A change in eating habits for the worse was reported by 22.88% of men and 28.26% of women (p<0.05). Increased appetite during the lockdown was reported by 24.18% of men and 35.47% of women (p<0.05), more frequent overeating during the pandemic occurred in 30.07% of men and 38.13% of women. When evaluating the consumption of individual food commodities, the increased consumption of fresh fruit, fresh vegetables (p<0.01), homemade bread (p<0.05), homemade pastries (p<0.05) and dairy products (p<0.05) is very favourable. We also found a significant increase in the consumption of sweets (p<0.01) and coffee (p<0.001). When evaluating the sleep pattern, we noted an increase in sleep during the pandemic, as well as more time spent sitting. Over half of the respondents reported a change in body weight, in most cases it was an increase in both sexes.

Conclusions: The results show that the pandemic and the restrictions during it caused changes not only in diet, but also in physical activity, daily routine and overall lifestyle. However, this is a very specific issue that needs to be assessed in a comprehensive and strictly personalized manner. The positive or negative impact of the pandemic on the health of the population will be the subject of research in the near future.

背景:冠状病毒引起的COVID-19大流行伴随着各种不利条件的出现,以及从慢性病角度来看健康状况的恶化,以及与某些食物偏好相关的生活方式改变和由于限制自由行动而导致的体重变化。目的:我们调查的目的是评估大流行和封锁对影响斯洛伐克人口整体健康状况的选定关键生活方式要素的影响,随后评估主观评估的受访者饮食习惯、日常生活、身体活动和体重的变化。材料和方法:研究小组由528名参与者组成,他们参加了在线分发的问卷调查。结果:受访者主观评价生活方式的改变相当消极。多达48.37%的男性和38.93%的女性表示情况在恶化。近59%的参与者报告他们的健康状况没有变化,而近四分之一的人报告他们的健康状况略有恶化。22.88%的男性和28.26%的女性报告了饮食习惯的改变(结论:结果表明,大流行及其期间的限制不仅导致了饮食的改变,还导致了身体活动、日常生活和整体生活方式的改变。然而,这是一个非常具体的问题,需要以全面和严格个性化的方式进行评估。该流行病对人口健康的积极或消极影响将是近期研究的主题。
{"title":"Impact of the COVID-19 pandemic on the changes in dietary habits, lifestyle and physical activity in the Slovak population.","authors":"Marta Lorková,&nbsp;Martina Gažarová","doi":"10.32394/rpzh.2023.0268","DOIUrl":"https://doi.org/10.32394/rpzh.2023.0268","url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 pandemic caused by the coronavirus was accompanied by the emergence of various adverse conditions, as well as the deterioration of health from the point of view of chronic diseases, as well as lifestyle changes related to the preference of certain foods and changes in body weight due to the restriction of free movement.</p><p><strong>Objective: </strong>The objective of our survey was to assess the impact of the pandemic and lockdown on selected key lifestyle elements affecting the overall health status of the Slovak population and subsequently to evaluate subjectively assessed changes in the respondents' eating habits, daily routine, physical activity and body weight.</p><p><strong>Material and methods: </strong>The research group consisted of 528 participants who took part in an online distributed questionnaire survey.</p><p><strong>Results: </strong>Respondents subjectively evaluated the change in lifestyle rather negatively. Up to 48.37% of men and 38.93% of women reported a change for the worse. Almost 59% of participants reported no change in their health, while almost a quarter reported a slight deterioration in their health. A change in eating habits for the worse was reported by 22.88% of men and 28.26% of women (p<0.05). Increased appetite during the lockdown was reported by 24.18% of men and 35.47% of women (p<0.05), more frequent overeating during the pandemic occurred in 30.07% of men and 38.13% of women. When evaluating the consumption of individual food commodities, the increased consumption of fresh fruit, fresh vegetables (p<0.01), homemade bread (p<0.05), homemade pastries (p<0.05) and dairy products (p<0.05) is very favourable. We also found a significant increase in the consumption of sweets (p<0.01) and coffee (p<0.001). When evaluating the sleep pattern, we noted an increase in sleep during the pandemic, as well as more time spent sitting. Over half of the respondents reported a change in body weight, in most cases it was an increase in both sexes.</p><p><strong>Conclusions: </strong>The results show that the pandemic and the restrictions during it caused changes not only in diet, but also in physical activity, daily routine and overall lifestyle. However, this is a very specific issue that needs to be assessed in a comprehensive and strictly personalized manner. The positive or negative impact of the pandemic on the health of the population will be the subject of research in the near future.</p>","PeriodicalId":35951,"journal":{"name":"Roczniki Panstwowego Zakladu Higieny","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10568444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibacterial activity of essential oils of Salvia Officinalis growing in Morocco. 摩洛哥丹参精油的抗菌活性。
Q2 Medicine Pub Date : 2023-01-01 DOI: 10.32394/rpzh.2023.0275
Youssef Lahlou, Sara Moujabbir, Abdelghani Aboukhalaf, Belkassem El Amraoui, Toufiq Bamhaoud

Background: The bacterial infections treatment is complicated by antibiotic resistance. In this fact, the need for new therapeutic approaches to control bacterial infections is crucial. Therefore, discovering new antibiotics from medicinal plants, able to kill drug-resistant bacteria, is essential to saving modern medicine.

Objective: This study was to evaluate the in vitro antibacterial activity of Salvia officinalis essential oil (SoEO) growing in Morocco.

Material and methods: The essential oil was extracted by hydro distillation, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined by agar dilution method. The essential oil was analyzed by Fourier-transform infrared spectroscopy (FTIR) and fractionated/purified using column chromatography followed by thin-layer chromatography (TLC).

Results: The results revealed that SoEO showed higher antimicrobial activity against Enterococcus faecalis and Citrobacter freundii. Fourier-transform infrared spectroscopy (FTIR) analysis, and purification/fractionation of SoEO, indicates that the most polar fraction F6 is the active fraction of SoEO. This finding can be explained by the existence of polar compounds in this fraction including alcohols, and phenols as thymol, eugenol, globulol, and spathulenol.

Conclusions: It can be conclude that alcohols and phenols from Salvia officinalis essential oil (SoEO) have promising antibacterial activity. This action can offer a great possibility of the application of SoEO in the treatment of bacterial diseases.

背景:细菌感染的治疗因抗生素耐药性而变得复杂。在这种情况下,我们需要新的治疗方法来控制细菌感染。因此,从药用植物中发现能够杀死耐药细菌的新抗生素对于拯救现代医学至关重要:本研究旨在评估生长在摩洛哥的丹参精油(SoEO)的体外抗菌活性:材料和方法:采用水蒸馏法提取精油,用琼脂稀释法测定最低抑菌浓度(MIC)和最低杀菌浓度(MBC)。精油采用傅立叶变换红外光谱法(FTIR)进行分析,并用柱层析法(Lar chromatography)和薄层色谱法(TLC)进行分馏/纯化:结果表明,SoEO 对粪肠球菌和自由柠檬酸杆菌具有较高的抗菌活性。傅立叶变换红外光谱(FTIR)分析和 SoEO 的纯化/分馏表明,极性最强的馏分 F6 是 SoEO 的活性馏分。这一发现的原因是该馏分中存在极性化合物,包括醇类和酚类,如百里酚、丁香酚、球醇和石杉烯醇:结论:可以得出结论,丹参精油(SoEO)中的醇类和酚类具有良好的抗菌活性。这种作用为将丹参精油应用于治疗细菌性疾病提供了极大的可能性。
{"title":"Antibacterial activity of essential oils of Salvia Officinalis growing in Morocco.","authors":"Youssef Lahlou, Sara Moujabbir, Abdelghani Aboukhalaf, Belkassem El Amraoui, Toufiq Bamhaoud","doi":"10.32394/rpzh.2023.0275","DOIUrl":"10.32394/rpzh.2023.0275","url":null,"abstract":"<p><strong>Background: </strong>The bacterial infections treatment is complicated by antibiotic resistance. In this fact, the need for new therapeutic approaches to control bacterial infections is crucial. Therefore, discovering new antibiotics from medicinal plants, able to kill drug-resistant bacteria, is essential to saving modern medicine.</p><p><strong>Objective: </strong>This study was to evaluate the in vitro antibacterial activity of Salvia officinalis essential oil (SoEO) growing in Morocco.</p><p><strong>Material and methods: </strong>The essential oil was extracted by hydro distillation, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined by agar dilution method. The essential oil was analyzed by Fourier-transform infrared spectroscopy (FTIR) and fractionated/purified using column chromatography followed by thin-layer chromatography (TLC).</p><p><strong>Results: </strong>The results revealed that SoEO showed higher antimicrobial activity against Enterococcus faecalis and Citrobacter freundii. Fourier-transform infrared spectroscopy (FTIR) analysis, and purification/fractionation of SoEO, indicates that the most polar fraction F6 is the active fraction of SoEO. This finding can be explained by the existence of polar compounds in this fraction including alcohols, and phenols as thymol, eugenol, globulol, and spathulenol.</p><p><strong>Conclusions: </strong>It can be conclude that alcohols and phenols from Salvia officinalis essential oil (SoEO) have promising antibacterial activity. This action can offer a great possibility of the application of SoEO in the treatment of bacterial diseases.</p>","PeriodicalId":35951,"journal":{"name":"Roczniki Panstwowego Zakladu Higieny","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138809370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of 6-week consumption of bakery products on changes in selected anthropometric parameters in women. 连续 6 周食用烘焙食品对女性某些人体测量参数变化的影响。
Q2 Medicine Pub Date : 2023-01-01 DOI: 10.32394/rpzh.2023.0278
Petra Lenártová, Martina Gažarová

Background: The changes in consumers' eating habits are one of the most important factors affecting the consumption of selected foods. The most important factors for bakery products consumers are freshness, taste, price, durability, composition, and country of origin.

Objective: The aim of this study was to monitor changes in selected anthropometric characteristics in women from the general population in Slovakia, after 6 weeks of bakery products consumption.

Material and methods: The study was conducted on healthy adult women from the general population (n=78), who were divided into four subgroups ("gluten" group, "gluten-free" group, "whole-grain" group and "control" group). The intervention dose consisted of a different combination of several types of bakery products (bread, pastries, soft pastries) within the individual weeks of consumption, while the intervention lasted 6 weeks, women consumed 150-200 grams per day. Anthropometric characteristics were measured by body composition analyser InBody 720 (Biospace Co. Ltd., Seoul, Republic of Korea), which works on the principle of bioelectrical impedance analysis. We also used the Lookin´Body 3.0 software to process the results. The collected data from these measurements were evaluated statistically and graphically in Microsoft Office Excel 2010 (Los Angeles, CA, USA). The levels of statistical significance were set at P<0.05 (*); P<0.01 (**); P<0.001 (***). Differences among subgroups of probands were tested with Pared Student t-test.

Results: The amount of fat mass (FM) in the participants changed along a similar curve as their body weight. After the 6-week intervention, there was a slight decrease in FM with statistical significance (P<0.01). In the third measurement, i.e., two months after the intervention, there was an increase in the amount of FM, but without statistical significance. Fat free mass (FFM) values in women increased very slightly after 6 weeks of consumption and remained approximately at the same level two months after the intervention (without statistical significance). We noted the most significant changes in the visceral fat area (VFA) parameter, which had a steadily increasing tendency. Changes in VFA values were statistically significant after the 6-week intervention (P<0.01) and also after two months of the intervention (P<0.05).

Conclusions: Changes in body composition in women were noted already after 6 weeks of bakery products consumption, especially in the FM, FFM, VFA and partially BMI parameters, but no changes were recorded in the WHR parameters during the entire duration of the study. One of the most significant results is the finding that there was an increase in VFA when consuming all types of bakery products (gluten, gluten-free and whole grain).

背景:消费者饮食习惯的改变是影响特定食品消费的最重要因素之一。对烘焙食品消费者来说,最重要的因素是新鲜度、口味、价格、耐久性、成分和原产国:本研究旨在监测斯洛伐克普通人群中的妇女在食用烘焙食品 6 周后某些人体测量特征的变化:研究对象是来自普通人群的健康成年女性(人数=78),她们被分为四个亚组("麸质 "组、"无麸质 "组、"全麦 "组和 "对照 "组)。干预剂量由几种烘焙食品(面包、糕点、软糕点)的不同组合组成,每星期食用一次,干预持续 6 周,妇女每天食用 150-200 克。人体成分分析仪 InBody 720(Biospace 有限公司,韩国首尔)根据生物电阻抗分析原理测量了人体特征。我们还使用 Lookin´Body 3.0 软件对结果进行处理。我们使用 Microsoft Office Excel 2010(美国加利福尼亚州洛杉矶市)对这些测量数据进行了统计和图形评估。统计显著性水平设定为 PResults:参与者的脂肪量(FM)变化曲线与体重变化曲线相似。经过 6 周的干预后,脂肪量略有减少,但有统计学意义(PC 结论:食用烘焙食品 6 周后,女性的身体成分已经发生了变化,特别是在脂肪含量、全脂脂肪含量、膳食脂肪酸和部分体重指数参数方面,但在整个研究期间,体重指数参数没有发生变化。其中一个最重要的结果是,在食用所有类型的烘焙食品(麸质食品、无麸质食品和全谷物食品)后,发现 VFA 有所增加。
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引用次数: 0
Impact of environmental heat exposure on the health status in farmworkers, Nakhon Ratchasima, Thailand. 环境热暴露对泰国那空叻差玛农场工人健康状况的影响
Q2 Medicine Pub Date : 2023-01-01 DOI: 10.32394/rpzh.2023.0250
Ekarat Sombatsawat, Titaporn Luangwilai, Chuthamat Kaewchandee, Mark Gregory Robson, Wattasit Siriwong

Background: Thailand is a tropical developing country which has a serious increase in health risk due to hot weather exposure among outdoor workers.

Objectives: The aims of this study were to compare the factors related to environmental heat exposure in three different seasons, and to assess the relationship between environmental heat and dehydration status in each season among farmworkers in Nakhon Ratchasima, Thailand.

Methods: A semi-longitudinal study was carried out in 22 male farmworkers throughout a year of farming. The primary data were collected in farmworkers for socio-demographic information, clinical assessments, and heat-related illnesses.

Results: Average of environmental heat index (Median, SD) were severe in summer (WBGT=38.1, 2.8°C), rainy season (WBGT=36.1, 2.1°C), and winter (WBGT=31.5, 2.7°C). Average urine Sp. Gr. in summer, rainy season, and winter were 1.022, 1.020, and 1.018 respectively. The third sentence should be corrected as follows: The Friedman analysis revealed a statistically significant difference between the three different seasons in WBGT (wet bulb globe temperature), body temperature, heart rate (P<0.01), and respiratory rate (P<0.05). There was a statistically significant difference between the three different seasons for skin rash/itching, dizziness, muscle cramp dyspnea (P<0.05), and weakness (P<0.01). Wilcoxon signed-ranks analysis found a significant difference in the medians of the paired sets of urine Sp. Gr. values between baseline and summer (P<0.05). Spearman's rank correlation coefficient did not find a relationship between WBGT and urine Sp. Gr. in the three different seasons.

Conclusions: This study demonstrated that farmworkers had exposure to environmental heat stress which was expressed through physical changes. Therefore, there is a need for either interventions or guidelines to prevent dehydration for outdoor workers in this region.

背景:泰国是一个热带发展中国家,由于户外工作者暴露在炎热的天气中,健康风险严重增加。目的:本研究的目的是比较三个不同季节与环境热暴露相关的因素,并评估泰国那空叻差玛(Nakhon Ratchasima)农场工人每个季节环境热与脱水状况之间的关系。方法:对22名男性农场工人进行了为期一年的半纵向研究。主要数据收集于农场工人,用于社会人口统计信息、临床评估和与热有关的疾病。结果:夏季(WBGT=38.1, 2.8°C)、雨季(WBGT=36.1, 2.1°C)和冬季(WBGT=31.5, 2.7°C)环境热指数平均值(Median, SD)较重。夏季、雨季和冬季平均尿液Sp. gr分别为1.022、1.020和1.018。第三句应该更正如下:Friedman分析显示,三个季节在WBGT(湿球温度)、体温、心率方面存在统计学上的显著差异(p)。结论:本研究表明,农场工人暴露于环境热应激,并通过身体变化表现出来。因此,有必要采取干预措施或制定指导方针,以防止该地区户外工作人员脱水。
{"title":"Impact of environmental heat exposure on the health status in farmworkers, Nakhon Ratchasima, Thailand.","authors":"Ekarat Sombatsawat,&nbsp;Titaporn Luangwilai,&nbsp;Chuthamat Kaewchandee,&nbsp;Mark Gregory Robson,&nbsp;Wattasit Siriwong","doi":"10.32394/rpzh.2023.0250","DOIUrl":"https://doi.org/10.32394/rpzh.2023.0250","url":null,"abstract":"<p><strong>Background: </strong>Thailand is a tropical developing country which has a serious increase in health risk due to hot weather exposure among outdoor workers.</p><p><strong>Objectives: </strong>The aims of this study were to compare the factors related to environmental heat exposure in three different seasons, and to assess the relationship between environmental heat and dehydration status in each season among farmworkers in Nakhon Ratchasima, Thailand.</p><p><strong>Methods: </strong>A semi-longitudinal study was carried out in 22 male farmworkers throughout a year of farming. The primary data were collected in farmworkers for socio-demographic information, clinical assessments, and heat-related illnesses.</p><p><strong>Results: </strong>Average of environmental heat index (Median, SD) were severe in summer (WBGT=38.1, 2.8°C), rainy season (WBGT=36.1, 2.1°C), and winter (WBGT=31.5, 2.7°C). Average urine Sp. Gr. in summer, rainy season, and winter were 1.022, 1.020, and 1.018 respectively. The third sentence should be corrected as follows: The Friedman analysis revealed a statistically significant difference between the three different seasons in WBGT (wet bulb globe temperature), body temperature, heart rate (P<0.01), and respiratory rate (P<0.05). There was a statistically significant difference between the three different seasons for skin rash/itching, dizziness, muscle cramp dyspnea (P<0.05), and weakness (P<0.01). Wilcoxon signed-ranks analysis found a significant difference in the medians of the paired sets of urine Sp. Gr. values between baseline and summer (P<0.05). Spearman's rank correlation coefficient did not find a relationship between WBGT and urine Sp. Gr. in the three different seasons.</p><p><strong>Conclusions: </strong>This study demonstrated that farmworkers had exposure to environmental heat stress which was expressed through physical changes. Therefore, there is a need for either interventions or guidelines to prevent dehydration for outdoor workers in this region.</p>","PeriodicalId":35951,"journal":{"name":"Roczniki Panstwowego Zakladu Higieny","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9248524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Bio-demographic characteristics of households and risk factors for Down Syndrome in Morocco. 摩洛哥家庭的生物人口特征和唐氏综合症的风险因素。
Q2 Medicine Pub Date : 2023-01-01 DOI: 10.32394/rpzh.2023.0283
Zahra Oulmane, Mohamed Cherkaoui, Rekia Belahsen, Mohamed Kamal Hilali

Background: The most studied risk factors for Down Syndrom (DS) were: region of residence, exposure to chemicals, parents' education level, cigarette and alcohol use by father or mother or both, and oral contraceptive (OC) use.

Objective: The aim of this study was to compare certain variables considered as risk factors on DS such as parental age at birth, OC use, child's sex, and rank of birth between children with DS and their siblings without DS as well as to determine the socio-bio-demographic characteristics of the families studied compared with the general Moroccan population.

Material and methods: We conducted a cross-sectional analysis of 277 families with 925 siblings and at least one child with DS (279 with DS) between 2014 and 2017. The data are collected using a standardized questionnaire in MarrakechSafi region. Data were entered and analyzed using the statistical program SPSS statistics software for Windows (version 20.0). Chi-square (χ2) and Student t tests were used for testing statistical significance. Differences were considered significant when the p-value <0.05.

Results: The binary logistic regression analysis between DS and non-DS children in their bio-demographic characteristics studied (sex, maternal age at birth, paternal age at birth, oral contraceptive (OC) use, length of oral contraceptive use before pregnancy and rank of birth) showed that only maternal age and paternal age at birth and OC use were associated with DS birth (OR= 1.16; 95% CL: 1.11-1.21, OR= 1.05; 95%CL: 1.01-1.09 and OR= 0.01; 95%CL: 0.00-0.003, respectively). In the other hand, the comparison between socio and bio-demographic characteristics of households studied with data from National Population Survey and Family health (2018) showed a higher level of education in women and men in our sample. Similar results were shown in rate of men and women in paid employment, the rate of smoking and alcohol consumption among men and the rate of OC use before pregnancy among women.

Conclusion: These results will help to sensitize the Moroccan population about risk factors for DS.

背景:研究最多的唐氏综合征(Down Syndrom,DS)风险因素是:居住地区、接触化学品、父母的教育水平、父亲或母亲或双方吸烟和酗酒,以及口服避孕药(OC)的使用:本研究的目的是比较被认为是 DS 风险因素的某些变量,如父母的出生年龄、口服避孕药的使用情况、孩子的性别以及患有 DS 的孩子与没有 DS 的兄弟姐妹之间的出生等级,并确定所研究家庭的社会-生物-人口特征与摩洛哥总人口的社会-生物-人口特征:我们对 2014 年至 2017 年间 277 个家庭的 925 名兄弟姐妹和至少一名 DS 患儿(279 名 DS 患儿)进行了横断面分析。数据是通过马拉喀什-萨菲地区的标准化问卷收集的。数据使用 Windows 版 SPSS 统计软件(20.0 版)进行输入和分析。采用卡方检验(χ2)和学生 t 检验来检验统计显著性。当 p 值为 0 时,差异被认为是显著的:对 DS 儿童和非 DS 儿童的生物统计学特征(性别、母亲的出生年龄、父亲的出生年龄、口服避孕药(OC)的使用情况、怀孕前口服避孕药的时间和出生等级)进行的二元逻辑回归分析表明,只有母亲的出生年龄、父亲的出生年龄和口服避孕药的使用情况与 DS 出生相关(OR= 1.16;95%CL:1.11-1.21,OR= 1.05;95%CL:1.01-1.09 和 OR=0.01;95%CL:0.00-0.003)。另一方面,将所研究家庭的社会和生物人口特征与全国人口调查和家庭健康(2018 年)的数据进行比较后发现,在我们的样本中,女性和男性的受教育程度较高。男女有偿就业率、男性吸烟和饮酒率以及女性孕前使用 OC 的比率也显示出类似的结果:这些结果将有助于提高摩洛哥人对 DS 风险因素的认识。
{"title":"Bio-demographic characteristics of households and risk factors for Down Syndrome in Morocco.","authors":"Zahra Oulmane, Mohamed Cherkaoui, Rekia Belahsen, Mohamed Kamal Hilali","doi":"10.32394/rpzh.2023.0283","DOIUrl":"10.32394/rpzh.2023.0283","url":null,"abstract":"<p><strong>Background: </strong>The most studied risk factors for Down Syndrom (DS) were: region of residence, exposure to chemicals, parents' education level, cigarette and alcohol use by father or mother or both, and oral contraceptive (OC) use.</p><p><strong>Objective: </strong>The aim of this study was to compare certain variables considered as risk factors on DS such as parental age at birth, OC use, child's sex, and rank of birth between children with DS and their siblings without DS as well as to determine the socio-bio-demographic characteristics of the families studied compared with the general Moroccan population.</p><p><strong>Material and methods: </strong>We conducted a cross-sectional analysis of 277 families with 925 siblings and at least one child with DS (279 with DS) between 2014 and 2017. The data are collected using a standardized questionnaire in MarrakechSafi region. Data were entered and analyzed using the statistical program SPSS statistics software for Windows (version 20.0). Chi-square (χ2) and Student t tests were used for testing statistical significance. Differences were considered significant when the p-value <0.05.</p><p><strong>Results: </strong>The binary logistic regression analysis between DS and non-DS children in their bio-demographic characteristics studied (sex, maternal age at birth, paternal age at birth, oral contraceptive (OC) use, length of oral contraceptive use before pregnancy and rank of birth) showed that only maternal age and paternal age at birth and OC use were associated with DS birth (OR= 1.16; 95% CL: 1.11-1.21, OR= 1.05; 95%CL: 1.01-1.09 and OR= 0.01; 95%CL: 0.00-0.003, respectively). In the other hand, the comparison between socio and bio-demographic characteristics of households studied with data from National Population Survey and Family health (2018) showed a higher level of education in women and men in our sample. Similar results were shown in rate of men and women in paid employment, the rate of smoking and alcohol consumption among men and the rate of OC use before pregnancy among women.</p><p><strong>Conclusion: </strong>These results will help to sensitize the Moroccan population about risk factors for DS.</p>","PeriodicalId":35951,"journal":{"name":"Roczniki Panstwowego Zakladu Higieny","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138809372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutritional value of gluten-free products using the front-of-pack labeling nutri-score. 使用包装正面标签营养评分计算无麸质产品的营养价值。
Q2 Medicine Pub Date : 2023-01-01 DOI: 10.32394/rpzh.2023.0277
Martina Gažarová, Petra Lenártová, Lucia Struharňanská

Background: Nutri-score is a useful and comprehensible system of extended nutrition labeling of food, which is intended to provide the consumer with simple guidance in choosing food products, taking into account the consumer's healthy diet. In several countries, in addition to the mandatory nutritional value of food indicated on the product packaging, the use of the so-called food traffic lights, which, based on a simple graphic display, make it easier for consumers to concentrate on choosing healthier food options.

Objective: The aim of the work was to evaluate the nutritional composition of gluten-free food products based on the nutritional data indicated on the packaging of these products in order to find out how useful the use of Front-of-Pack labeling (FOPL) Nutri-score will be in distinguishing the nutritional value of products.

Material and methods: We analyzed 206 randomly selected gluten-free food products obtained from commercial retail chains (semi-finished products, other bakery products, biscuits, flour mixtures, porridges, pasta, muesli, snacks, confectionery, etc.) intended for celiacs. Based on the obtained data, we evaluated the composition of the products using a modified algorithm for calculating the Nutri-score.

Results: We found that gluten-free products are a very rich source of energy, especially fats, carbohydrates and sugars, while the proportion of fiber and protein is very low. More than one third of the products had a nutritional score of category A or B, which are healthier variants, but over 40% of the analyzed products already fell into categories D or E. We found the lowest average energy value in the case of products classified in category B, the lowest average fat content and saturated fatty acids were found in products labeled A, the highest sugar content was found in products labeled D and E, the highest average protein content in products labeled A. The highest average salt content was found in products labeled C, fiber in products labeled B and A.

Conclusions: Nutritional profiling can significantly contribute to several health-beneficial decisions, especially when choosing and buying healthier food options, including gluten-free foods.

背景:营养评分(Nutri-score)是一个有用且易于理解的食品营养标签扩展系统,旨在为消费者选择食品提供简单的指导,同时考虑到消费者的健康饮食。在一些国家,除了在产品包装上强制标明食品的营养价值外,还使用了所谓的食品交通指示灯,它以简单的图形显示为基础,使消费者更容易集中精力选择更健康的食品:这项工作的目的是根据无麸质食品包装上标示的营养数据,评估这些产品的营养成分,以了解使用包装前标签(FOPL)营养分数在区分产品营养价值方面的作用:我们分析了从商业零售连锁店随机抽取的 206 种无麸质食品(半成品、其他烘焙食品、饼干、面粉混合物、粥、面食、麦片、零食、糖果等),这些产品都是为乳糜泻患者准备的。根据所获得的数据,我们使用经过改进的营养评分计算算法对产品的成分进行了评估:结果:我们发现,无麸质食品的能量来源非常丰富,尤其是脂肪、碳水化合物和糖类,而纤维和蛋白质的比例却非常低。我们发现 B 类产品的平均能量值最低,A 类产品的平均脂肪含量和饱和脂肪酸含量最低,D 类和 E 类产品的糖含量最高,A 类产品的平均蛋白质含量最高:营养成分分析可大大有助于做出一些有益健康的决定,尤其是在选择和购买更健康的食品(包括无麸质食品)时。
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引用次数: 0
World Health Organization MPOWER for tobacco control in India: a 6-year retrospective analysis. 世界卫生组织 MPOWER 在印度的烟草控制:6 年回顾性分析。
Q2 Medicine Pub Date : 2023-01-01 DOI: 10.32394/rpzh.2023.0282
Ravneet Malhi, Gitanjali Mago, Puneet Sharma, Ramandeep Singh Gambhir, Amit Aggarwal, Anupreet Paul

Background: Prevalence and practices of tobacco usage in India are diverse and incongruent and Government of India has enacted various laws to overcome this burden. To make tobacco control measures effective and powerful, WHO introduced MPOWER in 2004 and India was one of the first countries that implemented the MPOWER.

Objective: This study is aimed to quantify the implementation of MPOWER tobacco control policies in India.

Material and methods: In this retrospective analysis, data was gathered from the WHO MPOWER of India from 2015 to 2021. This analysis was based on the checklist which was designed previously by Iranian and international tobacco control specialists in their study on tobacco control.

Results: In the present comparative analysis, India was categorized by scores and these were acquired from each indicator for each activity and 2021 year got the highest scores as compared to the previous year scores i.e. 27 in 2015. In context to individual indicators, noticeable increase in scores has been seen in both health warning on cigarette packages and adult daily smoking prevalence, whereas no progress was observed in smoking related policies.

Conclusion: Although MPOWER programmes are widely accepted by the Indian government, but still substantial improvement in fewer sections is required.

背景:在印度,烟草使用的流行率和做法多种多样且不协调,印度政府已颁布各种法律来克服这一负担。为了使烟草控制措施更加有效和有力,世界卫生组织于 2004 年推出了 MPOWER 计划,印度是首批实施 MPOWER 计划的国家之一:本研究旨在量化 MPOWER 烟草控制政策在印度的实施情况:在这项回顾性分析中,我们从世界卫生组织的印度 MPOWER 中收集了 2015 年至 2021 年的数据。本分析基于伊朗和国际烟草控制专家之前在烟草控制研究中设计的核对表:在本比较分析中,印度按得分进行分类,这些得分来自每项活动的每个指标,与前一年的得分(即 2015 年的 27 分)相比,2021 年的得分最高。就单个指标而言,香烟包装上的健康警示和成人每日吸烟率的得分都有明显提高,而与吸烟相关的政策则没有取得进展:尽管 MPOWER 计划得到了印度政府的广泛认可,但仍需在较少的领域做出实质性改进。
{"title":"World Health Organization MPOWER for tobacco control in India: a 6-year retrospective analysis.","authors":"Ravneet Malhi, Gitanjali Mago, Puneet Sharma, Ramandeep Singh Gambhir, Amit Aggarwal, Anupreet Paul","doi":"10.32394/rpzh.2023.0282","DOIUrl":"10.32394/rpzh.2023.0282","url":null,"abstract":"<p><strong>Background: </strong>Prevalence and practices of tobacco usage in India are diverse and incongruent and Government of India has enacted various laws to overcome this burden. To make tobacco control measures effective and powerful, WHO introduced MPOWER in 2004 and India was one of the first countries that implemented the MPOWER.</p><p><strong>Objective: </strong>This study is aimed to quantify the implementation of MPOWER tobacco control policies in India.</p><p><strong>Material and methods: </strong>In this retrospective analysis, data was gathered from the WHO MPOWER of India from 2015 to 2021. This analysis was based on the checklist which was designed previously by Iranian and international tobacco control specialists in their study on tobacco control.</p><p><strong>Results: </strong>In the present comparative analysis, India was categorized by scores and these were acquired from each indicator for each activity and 2021 year got the highest scores as compared to the previous year scores i.e. 27 in 2015. In context to individual indicators, noticeable increase in scores has been seen in both health warning on cigarette packages and adult daily smoking prevalence, whereas no progress was observed in smoking related policies.</p><p><strong>Conclusion: </strong>Although MPOWER programmes are widely accepted by the Indian government, but still substantial improvement in fewer sections is required.</p>","PeriodicalId":35951,"journal":{"name":"Roczniki Panstwowego Zakladu Higieny","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138809535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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