{"title":"Leading In the Skin You're In: A Conversation with Dr. Tawana Grover and Dr. Steve Joel","authors":"R. Teten","doi":"10.1353/gpr.2021.0019","DOIUrl":"https://doi.org/10.1353/gpr.2021.0019","url":null,"abstract":"","PeriodicalId":35980,"journal":{"name":"Great Plains Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66406060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Introduced Tree, Black Locust, and Its Non-Native Treehoppers Augment Nebraska’s Biodiversity","authors":"A. G. Wheeler","doi":"10.1353/GPR.2021.0001","DOIUrl":"https://doi.org/10.1353/GPR.2021.0001","url":null,"abstract":"","PeriodicalId":35980,"journal":{"name":"Great Plains Research","volume":"31 1","pages":"17-33"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1353/GPR.2021.0001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66406081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Silver Bullet: Gun Ownership and Political Participation in Rural America","authors":"Alexandra T. Middlewood","doi":"10.1353/gpr.2021.0022","DOIUrl":"https://doi.org/10.1353/gpr.2021.0022","url":null,"abstract":"","PeriodicalId":35980,"journal":{"name":"Great Plains Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66406138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-01eCollection Date: 2022-03-01DOI: 10.1016/j.gendis.2020.11.014
Duguang Li, Xiaoxiao Fan, Yirun Li, Jing Yang, Hui Lin
Hepatocellular carcinoma (HCC) is among the most aggressive and lethal diseases with poor prognosis, worldwide. However, the mechanisms underlying HCC have not been comprehensively elucidated. With the recent application of high-throughput sequencing techniques, a diverse catalogue of differentially expressed long non-coding RNAs (lncRNA) in cancer have been shown to participate in HCC. Rather than being "transcriptional noise," they are emerging as important regulators of many biological processes, including chromatin remodelling, transcription, alternative splicing, translational and post-translational modification. Moreover, lncRNAs have dual effects in the development and progression of HCC, including oncogenic and tumour-suppressive roles. Collectively, recently data point to lncRNAs as novel diagnostic and prognostic biomarkers with satisfactory sensitivity and specificity, as well as being therapeutic targets for HCC patients. In this review, we highlight recent progress of the molecular patterns of lncRNAs and discuss their potential clinical application in human HCC.
{"title":"The paradoxical functions of long noncoding RNAs in hepatocellular carcinoma: Implications in therapeutic opportunities and precision medicine.","authors":"Duguang Li, Xiaoxiao Fan, Yirun Li, Jing Yang, Hui Lin","doi":"10.1016/j.gendis.2020.11.014","DOIUrl":"10.1016/j.gendis.2020.11.014","url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC) is among the most aggressive and lethal diseases with poor prognosis, worldwide. However, the mechanisms underlying HCC have not been comprehensively elucidated. With the recent application of high-throughput sequencing techniques, a diverse catalogue of differentially expressed long non-coding RNAs (lncRNA) in cancer have been shown to participate in HCC. Rather than being \"transcriptional noise,\" they are emerging as important regulators of many biological processes, including chromatin remodelling, transcription, alternative splicing, translational and post-translational modification. Moreover, lncRNAs have dual effects in the development and progression of HCC, including oncogenic and tumour-suppressive roles. Collectively, recently data point to lncRNAs as novel diagnostic and prognostic biomarkers with satisfactory sensitivity and specificity, as well as being therapeutic targets for HCC patients. In this review, we highlight recent progress of the molecular patterns of lncRNAs and discuss their potential clinical application in human HCC.</p>","PeriodicalId":35980,"journal":{"name":"Great Plains Research","volume":"25 1","pages":"358-369"},"PeriodicalIF":6.9,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88497648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synoptic Mechanisms behind Extreme Precipitation Event Frequency in Omaha, Nebraska, 1948–2018","authors":"Z. J. Suriano, Elizabeth Seckman","doi":"10.1353/gpr.2020.0017","DOIUrl":"https://doi.org/10.1353/gpr.2020.0017","url":null,"abstract":"","PeriodicalId":35980,"journal":{"name":"Great Plains Research","volume":"30 1","pages":"149-160"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1353/gpr.2020.0017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66405371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Who Owns Wells in Kansas? An Exploration of Rural Water Supply Reliance in the High Plains","authors":"Brock Ternes","doi":"10.1353/gpr.2020.0005","DOIUrl":"https://doi.org/10.1353/gpr.2020.0005","url":null,"abstract":"","PeriodicalId":35980,"journal":{"name":"Great Plains Research","volume":"30 1","pages":"71-86"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1353/gpr.2020.0005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66405476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Measuring Attitudes toward Ethanol Production and Use: A Case Study of Nebraska","authors":"Frank Tenkorang, F. Ziwoya","doi":"10.1353/gpr.2020.0000","DOIUrl":"https://doi.org/10.1353/gpr.2020.0000","url":null,"abstract":"","PeriodicalId":35980,"journal":{"name":"Great Plains Research","volume":"30 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1353/gpr.2020.0000","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66405235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Great Plains Ranchers Managing for Vegetation Heterogeneity: A Multiple Case Study","authors":"Stephanie Kennedy, M. Burbach","doi":"10.1353/gpr.2020.0016","DOIUrl":"https://doi.org/10.1353/gpr.2020.0016","url":null,"abstract":"","PeriodicalId":35980,"journal":{"name":"Great Plains Research","volume":"30 1","pages":"137-148"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1353/gpr.2020.0016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66405351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Invited Essay Climate Change and Water Management Challenges Facing the Great Plains","authors":"Dave Aiken, Katie Nieland","doi":"10.1353/gpr.2020.0012","DOIUrl":"https://doi.org/10.1353/gpr.2020.0012","url":null,"abstract":"","PeriodicalId":35980,"journal":{"name":"Great Plains Research","volume":"30 1","pages":"101-107"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1353/gpr.2020.0012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66405201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Idoate, M. Desmarais, Brittany Strong, A. Steinhoff, L. Tamayo, Gretchen K. Carroll, Chaulette DeCora, Cassie Rhoads-Carroll, Nicole Tamayo-Bergman, Camille Voorhees, Victoria Hoyt
{"title":"An Indigenist Theory of Health Advocacy","authors":"R. Idoate, M. Desmarais, Brittany Strong, A. Steinhoff, L. Tamayo, Gretchen K. Carroll, Chaulette DeCora, Cassie Rhoads-Carroll, Nicole Tamayo-Bergman, Camille Voorhees, Victoria Hoyt","doi":"10.1353/gpr.2020.0002","DOIUrl":"https://doi.org/10.1353/gpr.2020.0002","url":null,"abstract":"","PeriodicalId":35980,"journal":{"name":"Great Plains Research","volume":"30 1","pages":"35-48"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1353/gpr.2020.0002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66405259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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