Pub Date : 2021-08-02DOI: 10.9734/bpi/nfmmr/v1/2980f
Nidhi Jain, J. Kamra
Primary amenorrhea is described as the inability to reach menarche until the age of 14 in the lack of normal secondary sexual characteristics, or until the age of 16 in the absence of secondary sexual characteristics. Gonadal pathology is the most common cause of primary amenorrhea, followed by MRKH syndrome. MRKH syndrome is an uncommon congenital condition characterised by aplasia of the uterus and vaginal wall. It happens when the Mullerian duct fails to grow properly.It occurs once every 4500 female births. Primary amenorrhea affects mostly girls. It is defined by the presence of normal secondary sexual features, a normal 46 XX genotype, normal ovarian function in the majority of cases, and a missing or undeveloped uterus and upper part (2/3) of vagina. It is divided into two types: type A is an isolated condition, and type B is linked to various renal, skeletal, and cardiac anomalies. Psychological counselling and vaginoplasty are among the options for treatment. Vaginoplasty can be performed using a variety of non-surgical and surgical methods. The authors present a review of the literature on the embryology, etiopathogenesis, work-up, and therapy of MRKH syndrome.
{"title":"A Review of Literature on Mrkh Syndrome","authors":"Nidhi Jain, J. Kamra","doi":"10.9734/bpi/nfmmr/v1/2980f","DOIUrl":"https://doi.org/10.9734/bpi/nfmmr/v1/2980f","url":null,"abstract":"Primary amenorrhea is described as the inability to reach menarche until the age of 14 in the lack of normal secondary sexual characteristics, or until the age of 16 in the absence of secondary sexual characteristics. Gonadal pathology is the most common cause of primary amenorrhea, followed by MRKH syndrome. MRKH syndrome is an uncommon congenital condition characterised by aplasia of the uterus and vaginal wall. It happens when the Mullerian duct fails to grow properly.It occurs once every 4500 female births. Primary amenorrhea affects mostly girls. It is defined by the presence of normal secondary sexual features, a normal 46 XX genotype, normal ovarian function in the majority of cases, and a missing or undeveloped uterus and upper part (2/3) of vagina. It is divided into two types: type A is an isolated condition, and type B is linked to various renal, skeletal, and cardiac anomalies. Psychological counselling and vaginoplasty are among the options for treatment. Vaginoplasty can be performed using a variety of non-surgical and surgical methods. The authors present a review of the literature on the embryology, etiopathogenesis, work-up, and therapy of MRKH syndrome.","PeriodicalId":360142,"journal":{"name":"New Frontiers in Medicine and Medical Research Vol. 1","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123907139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-02DOI: 10.9734/bpi/nfmmr/v1/3127f
Deepti Yadav, Mukta Meel, D. Hemrajani, A. Mittal, K. Mathur
Background: Mammary fibroepithelial lesions cover a wide range of malignancies, from indolent fibroadenoma to the potentially fatal phyllodes tumor (PT). The morphological assessment criteria used for classification are typically difficult to apply, and there is no consensus on what constitutes a sufficient resection margin. The current study objectives were to investigate the histopathological spectrum of fibroepithelial lesions of the breast at a tertiary care centre, to stratify and classify various fibroepithelial lesions into fibroadenomas and PT, and to reclassify all confirmed cases of PT seen during the study period using standard histopathological WHO criteria. Methods: Between January 2016 and August 2019, records and slides of fibroepithelial lesions of the breast obtained at the department were retrieved and reviewed. Results: During this time, 891 fibroepithelial lesions of the breast were discovered. There were 826 (92.7%) cases of fibroadenoma and its variations, 34 (3.8%) cases of fibroadenomatoid mastopathy, and 31 (3.5%) cases of PT. Eight (25.8%) of all PT were borderline, four (12.9%) were malignant, and the remaining (61.3%) were benign. Conclusions: Fibroepithelial tumours of the breast are a diverse group of lesions that range in severity from benign fibroadenoma to malignant PT. Various subtypes have overlapping histologic characteristics, and transformation and progression to a more malignant phenotype are possible. As there are significant clinical disparities among subtypes, precise pathologic categorization is critical for proper management. Despite the fact that some immunohistochemical markers may be helpful in this differential diagnosis, histomorphology is still the gold standard.
{"title":"Study of Fibroepithelial Lesions of Breast at a tertiary Care Centre- an Audit, Clinicopathological APPROACH and Comparison with WHO Grading","authors":"Deepti Yadav, Mukta Meel, D. Hemrajani, A. Mittal, K. Mathur","doi":"10.9734/bpi/nfmmr/v1/3127f","DOIUrl":"https://doi.org/10.9734/bpi/nfmmr/v1/3127f","url":null,"abstract":"Background: Mammary fibroepithelial lesions cover a wide range of malignancies, from indolent fibroadenoma to the potentially fatal phyllodes tumor (PT). The morphological assessment criteria used for classification are typically difficult to apply, and there is no consensus on what constitutes a sufficient resection margin. The current study objectives were to investigate the histopathological spectrum of fibroepithelial lesions of the breast at a tertiary care centre, to stratify and classify various fibroepithelial lesions into fibroadenomas and PT, and to reclassify all confirmed cases of PT seen during the study period using standard histopathological WHO criteria. \u0000Methods: Between January 2016 and August 2019, records and slides of fibroepithelial lesions of the breast obtained at the department were retrieved and reviewed. \u0000Results: During this time, 891 fibroepithelial lesions of the breast were discovered. There were 826 (92.7%) cases of fibroadenoma and its variations, 34 (3.8%) cases of fibroadenomatoid mastopathy, and 31 (3.5%) cases of PT. Eight (25.8%) of all PT were borderline, four (12.9%) were malignant, and the remaining (61.3%) were benign. \u0000Conclusions: Fibroepithelial tumours of the breast are a diverse group of lesions that range in severity from benign fibroadenoma to malignant PT. Various subtypes have overlapping histologic characteristics, and transformation and progression to a more malignant phenotype are possible. As there are significant clinical disparities among subtypes, precise pathologic categorization is critical for proper management. Despite the fact that some immunohistochemical markers may be helpful in this differential diagnosis, histomorphology is still the gold standard.","PeriodicalId":360142,"journal":{"name":"New Frontiers in Medicine and Medical Research Vol. 1","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116585108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-02DOI: 10.9734/bpi/nfmmr/v1/11258d
E. Topkan, A. Kucuk, D. Sezen, S. Senyurek, Eyub Yasar Aydemir, N. Durankus, Y. Bolukbasi, B. Pehlivan, U. Selek
Brain metastases (BMs) represent the most common intracranial tumors, and nearly 25% of all cancer patients are diagnosed with this poor prognostic disease condition somewhere during their treatment course. Depending on the potential patient's general well-being status, the main prevailing treatment options typically incorporate palliative radiotherapy, chemotherapy, targeted agents, immunotherapy, best supportive care, and less frequently surgery in select patients. Past investigations demonstrated the probability to stratify BM patients into particular prognostic gatherings according to the credible combinations of multiple patients- and tumor-related features: the prognostic scoring systems. Such frameworks may serve usefully in the accurate prediction of survival outcomes and the appropriate selection of the best-fit treatment elective. In this present review, we intended to survey the advantages and disadvantages of the broadly recognized on-the-spot prognostic scoring systems for BMs and their clinical merits.
{"title":"A Review on Brain Metastases Prognostic Scoring Systems","authors":"E. Topkan, A. Kucuk, D. Sezen, S. Senyurek, Eyub Yasar Aydemir, N. Durankus, Y. Bolukbasi, B. Pehlivan, U. Selek","doi":"10.9734/bpi/nfmmr/v1/11258d","DOIUrl":"https://doi.org/10.9734/bpi/nfmmr/v1/11258d","url":null,"abstract":"Brain metastases (BMs) represent the most common intracranial tumors, and nearly 25% of all cancer patients are diagnosed with this poor prognostic disease condition somewhere during their treatment course. Depending on the potential patient's general well-being status, the main prevailing treatment options typically incorporate palliative radiotherapy, chemotherapy, targeted agents, immunotherapy, best supportive care, and less frequently surgery in select patients. Past investigations demonstrated the probability to stratify BM patients into particular prognostic gatherings according to the credible combinations of multiple patients- and tumor-related features: the prognostic scoring systems. Such frameworks may serve usefully in the accurate prediction of survival outcomes and the appropriate selection of the best-fit treatment elective. In this present review, we intended to survey the advantages and disadvantages of the broadly recognized on-the-spot prognostic scoring systems for BMs and their clinical merits.","PeriodicalId":360142,"journal":{"name":"New Frontiers in Medicine and Medical Research Vol. 1","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117116508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-02DOI: 10.9734/bpi/nfmmr/v1/3149f
Vikas Singh, S. Dang
Background: The availability of safe, clinically useful, and cost-effective bone allografts have led to modifications in surgical therapy, as well as a rise in demand for bone allografts grafts for use in plastic surgery reconstruction. They are an appealing alternative to bone autograft because their supply is less limited, they allow structural restoration of the skeleton, and their surfaces promote bone formation. Case Series: We provide a case series of 13 patients who were treated with freeze-dried bone allografts. The FDA and the Bone Banks both advised that all grafts meet certain parameters. The objective evaluation of graft volume persistence was achieved using radiography, whereas the subjective estimation of graft volume was obtained through patient response throughout a one-year period of follow-up. Objective of this study was to establish the clinical use of bone allografts in various reconstructive surgeries and compare its utility with bone autografts. Conclusion: Bone allografts can be used in any type of bone surgery, from minor defects to major bone loss following tumour resection. Without donor-site morbidity, freeze-dried allograft bone is a safe and equal alternative to bone autograft.
{"title":"Varied Uses of Bone Allograft in Plastic and Reconstructive Surgery: A Case Series of 13 Patients","authors":"Vikas Singh, S. Dang","doi":"10.9734/bpi/nfmmr/v1/3149f","DOIUrl":"https://doi.org/10.9734/bpi/nfmmr/v1/3149f","url":null,"abstract":"Background: The availability of safe, clinically useful, and cost-effective bone allografts have led to modifications in surgical therapy, as well as a rise in demand for bone allografts grafts for use in plastic surgery reconstruction. They are an appealing alternative to bone autograft because their supply is less limited, they allow structural restoration of the skeleton, and their surfaces promote bone formation. \u0000Case Series: We provide a case series of 13 patients who were treated with freeze-dried bone allografts. The FDA and the Bone Banks both advised that all grafts meet certain parameters. The objective evaluation of graft volume persistence was achieved using radiography, whereas the subjective estimation of graft volume was obtained through patient response throughout a one-year period of follow-up. Objective of this study was to establish the clinical use of bone allografts in various reconstructive surgeries and compare its utility with bone autografts. \u0000Conclusion: Bone allografts can be used in any type of bone surgery, from minor defects to major bone loss following tumour resection. Without donor-site morbidity, freeze-dried allograft bone is a safe and equal alternative to bone autograft.","PeriodicalId":360142,"journal":{"name":"New Frontiers in Medicine and Medical Research Vol. 1","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132840034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-02DOI: 10.9734/bpi/nfmmr/v1/10757d
Lohit kumar Kalita, C. Kalita, P. Gogoi, U. Sharma
Primary cutaneous involvement in T-cell lymphoblastic leukemia is rare in childhood. We present a case of 6-year- old girl admitted to our hospital because of multiple skin lesions. She was looked pale and weak. Generalized lymphadenopathy was present. Complete blood count revealed 216,000/mm3 white blood cell count. Peripheral blood smear showed 80% lymphoblasts. Bone marrow aspiration revealed 96% blastic cells with immunophenotype and morphological characteristics of acute lymphoblastic leukemia (T-ALL) which was confirmed by flowcytometry. ALL BFM -95 remission induction treatment protocol was started. Skin lesion remained same after two month of the cytotoxic therapy. The symptoms became more aggressive and she died after 4 months of treatment.
{"title":"A Rare Case Report of Acute T-cell Lymphoblastic Leukaemia Presenting with Cutaneous Involvement in a Child","authors":"Lohit kumar Kalita, C. Kalita, P. Gogoi, U. Sharma","doi":"10.9734/bpi/nfmmr/v1/10757d","DOIUrl":"https://doi.org/10.9734/bpi/nfmmr/v1/10757d","url":null,"abstract":"Primary cutaneous involvement in T-cell lymphoblastic leukemia is rare in childhood. We present a case of 6-year- old girl admitted to our hospital because of multiple skin lesions. She was looked pale and weak. Generalized lymphadenopathy was present. Complete blood count revealed 216,000/mm3 white blood cell count. Peripheral blood smear showed 80% lymphoblasts. Bone marrow aspiration revealed 96% blastic cells with immunophenotype and morphological characteristics of acute lymphoblastic leukemia (T-ALL) which was confirmed by flowcytometry. ALL BFM -95 remission induction treatment protocol was started. Skin lesion remained same after two month of the cytotoxic therapy. The symptoms became more aggressive and she died after 4 months of treatment.","PeriodicalId":360142,"journal":{"name":"New Frontiers in Medicine and Medical Research Vol. 1","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115476340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-02DOI: 10.9734/bpi/nfmmr/v1/3196f
J. Campos, Plinio H. F. Leandro, L. D. O. Lima, C. Lima, L. Aquino, Marcos F. H. Rocha
Upper urinary tract urothelial carcinoma is a rare and possibly fatal disease. It sometimes affects the ureter, and it's even unusual in the ureteral stump of a patient who has had a nephrectomy for benign disease.The example of a male patient who underwent total left nephrectomy due to renal exclusion is described here. He was diagnosed with a urethral tumour of the ureteral stump after three years due to an episode of hematuria, and he had ureterectomy and bladder cuff excision. The ureteral stump being involved by a urothelial tumour is an incredibly rare occurrence that is usually linked with a poor prognosis due to the delay in detection caused by atypical presentation. Hematuria is the most prevalent symptom. Because there is no renal unit and hence no hydronephrosis, pain is uncommon.Although rare, primary tumours in the ureteral stump should be remembered, and a high level of diagnostic suspicion should be maintained to avoid diagnosis in the advanced stages. Our objective with this paper was to report a rare presentation of a urothelial carcinoma and to alert physicians.
{"title":"A Case Report on Urothelial Carcinoma in the Ureteral Stump of a Nefrectomized Patient by Kidney Exclusion","authors":"J. Campos, Plinio H. F. Leandro, L. D. O. Lima, C. Lima, L. Aquino, Marcos F. H. Rocha","doi":"10.9734/bpi/nfmmr/v1/3196f","DOIUrl":"https://doi.org/10.9734/bpi/nfmmr/v1/3196f","url":null,"abstract":"Upper urinary tract urothelial carcinoma is a rare and possibly fatal disease. It sometimes affects the ureter, and it's even unusual in the ureteral stump of a patient who has had a nephrectomy for benign disease.The example of a male patient who underwent total left nephrectomy due to renal exclusion is described here. He was diagnosed with a urethral tumour of the ureteral stump after three years due to an episode of hematuria, and he had ureterectomy and bladder cuff excision. The ureteral stump being involved by a urothelial tumour is an incredibly rare occurrence that is usually linked with a poor prognosis due to the delay in detection caused by atypical presentation. Hematuria is the most prevalent symptom. Because there is no renal unit and hence no hydronephrosis, pain is uncommon.Although rare, primary tumours in the ureteral stump should be remembered, and a high level of diagnostic suspicion should be maintained to avoid diagnosis in the advanced stages. Our objective with this paper was to report a rare presentation of a urothelial carcinoma and to alert physicians.","PeriodicalId":360142,"journal":{"name":"New Frontiers in Medicine and Medical Research Vol. 1","volume":"105 1-2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120924796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-02DOI: 10.9734/bpi/nfmmr/v1/3213f
Swati S. More, Vaishali Mane, Aruna Y. Yadav
Background: External ear is a defining feature of the face as it contributes to facial aesthetics by its appearance and symmetry. Its shape and size is influenced by age, sex and ethnic origin. Features of auricle had long been recognized as an important anthropological variable for studying racial variability and for identifying few genetic abnormalities at an early stage of life. Out of all available methods to study external ear indices, digital photometry is most convenient and useful method. Objectives: To study external ear indices using digital photometry among adult population. Methods: The present cross sectional study consisted of 500 adult subjects between 20 to 30 years of age. Patients with malignancies, previous surgery or trauma to the earlobe, or congenital earlobe anomalies were excluded. Ear features were then captured using a digital camera mounted on stand. Various soft tissue landmarks were tagged on the photo and the various tagged points were connected on the photo. Different parameters on right and left ear were measured. The indices like auricular, lobular and conchal were computed. The measurements were statistically analyzed by calculating their mean and standard deviations. Results: There were 250 women and 250 men. Oval shape of auricle was more common both in males as well as in females. Auricular and conchal index in males as well as females on right and left side were statistically insignificant. These indices were significantly different in both genders. Lobular index in males on right and left side was statistically not significant, but was significant in females. Gender wise lobular index on right side was statistically significant. Conclusion: The result of the present study also can be used in the field of Forensic Science for excluding criminals. Ear Biometrics is a promising new passive approach to Human Identification system used for screening people. This knowledge will be useful in designing a new identification tool-‘Ear Biometrics’
{"title":"Determination of External Ear Indices by Digital Photometry among Adult Population","authors":"Swati S. More, Vaishali Mane, Aruna Y. Yadav","doi":"10.9734/bpi/nfmmr/v1/3213f","DOIUrl":"https://doi.org/10.9734/bpi/nfmmr/v1/3213f","url":null,"abstract":"Background: External ear is a defining feature of the face as it contributes to facial aesthetics by its appearance and symmetry. Its shape and size is influenced by age, sex and ethnic origin. Features of auricle had long been recognized as an important anthropological variable for studying racial variability and for identifying few genetic abnormalities at an early stage of life. Out of all available methods to study external ear indices, digital photometry is most convenient and useful method. \u0000Objectives: To study external ear indices using digital photometry among adult population. \u0000Methods: The present cross sectional study consisted of 500 adult subjects between 20 to 30 years of age. Patients with malignancies, previous surgery or trauma to the earlobe, or congenital earlobe anomalies were excluded. Ear features were then captured using a digital camera mounted on stand. Various soft tissue landmarks were tagged on the photo and the various tagged points were connected on the photo. Different parameters on right and left ear were measured. The indices like auricular, lobular and conchal were computed. The measurements were statistically analyzed by calculating their mean and standard deviations. \u0000Results: There were 250 women and 250 men. Oval shape of auricle was more common both in males as well as in females. Auricular and conchal index in males as well as females on right and left side were statistically insignificant. These indices were significantly different in both genders. Lobular index in males on right and left side was statistically not significant, but was significant in females. Gender wise lobular index on right side was statistically significant. \u0000Conclusion: The result of the present study also can be used in the field of Forensic Science for excluding criminals. Ear Biometrics is a promising new passive approach to Human Identification system used for screening people. This knowledge will be useful in designing a new identification tool-‘Ear Biometrics’","PeriodicalId":360142,"journal":{"name":"New Frontiers in Medicine and Medical Research Vol. 1","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122433032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-02-01DOI: 10.9734/bpi/nfmmr/v1/11351d
Pramila Jain, V. Khare, Ashish Koshti, R. Malik, Bhawna Bhimte
Leprosy is a chronic infectious disease caused by Mycobacterium leprae. It principally affects the cooler parts of the body, mainly skin and peripheral nerves. Leprosy involves wide range of biochemical as well as immunological changes in the body including trace elements such as zinc, copper and magnesium. After iron, zinc is the second most abundant trace element in the body. This study has been undertaken to correlate with clinical presentations wherever possible and to investigate the level of serum zinc in leprosy. Study included 63 newly diagnosed leprosy. Cases were further distributed according to clinical subtypes and were compared to controls. Venous blood samples were collected and estimation of serum zinc level has been done with serum. Maximum patients detected were of Intermediate Leprosy (26.9) where as lesser (1.58)were of Histoid type. Pure tuberculoid and Indeterminate leprosy group showed minimum decrease and pure lepromatous and Erythema nodosum leprosum group showed maximum decrease in Serum Zinc level i.e. leprosy patients with increased bacterial load have decreased serum zinc levels. This suggests that there could be a correlation of serum zinc levels and the bacillary load.
{"title":"Serum Zinc Level Estimation- Comparision between Normal Control and in Leprosy Patients: Clinical Presentations","authors":"Pramila Jain, V. Khare, Ashish Koshti, R. Malik, Bhawna Bhimte","doi":"10.9734/bpi/nfmmr/v1/11351d","DOIUrl":"https://doi.org/10.9734/bpi/nfmmr/v1/11351d","url":null,"abstract":"Leprosy is a chronic infectious disease caused by Mycobacterium leprae. It principally affects the cooler parts of the body, mainly skin and peripheral nerves. Leprosy involves wide range of biochemical as well as immunological changes in the body including trace elements such as zinc, copper and magnesium. After iron, zinc is the second most abundant trace element in the body. \u0000This study has been undertaken to correlate with clinical presentations wherever possible and to investigate the level of serum zinc in leprosy. Study included 63 newly diagnosed leprosy. Cases were further distributed according to clinical subtypes and were compared to controls. Venous blood samples were collected and estimation of serum zinc level has been done with serum. \u0000Maximum patients detected were of Intermediate Leprosy (26.9) where as lesser (1.58)were of Histoid type. Pure tuberculoid and Indeterminate leprosy group showed minimum decrease and pure lepromatous and Erythema nodosum leprosum group showed maximum decrease in Serum Zinc level i.e. leprosy patients with increased bacterial load have decreased serum zinc levels. This suggests that there could be a correlation of serum zinc levels and the bacillary load.","PeriodicalId":360142,"journal":{"name":"New Frontiers in Medicine and Medical Research Vol. 1","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133581595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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