American Journal of Obstetrics & Gynecology Mfm最新文献

{"title":"Placental cytogenetic testing for confined placental mosaicism and obstetrical outcomes after discordant cell-free DNA screening results.","authors":"Yvette Raymond, Shavi Fernando, Melody Menezes, Ben W Mol, Emma Brown, Kirsten Arnold, Daniel L Rolnik","doi":"10.1016/j.ajogmf.2025.101887","DOIUrl":"10.1016/j.ajogmf.2025.101887","url":null,"abstract":"<p><strong>Background: </strong>A false-positive cell-free DNA prenatal screening result may arise from confined placental mosaicism, however, the frequency and obstetrical ramifications of such cases are poorly understood.</p><p><strong>Objective: </strong>This study aimed to assess the prevalence of confined placental mosaicism among pregnancies with false-positive cell-free DNA results and the associated obstetrical outcomes.</p><p><strong>Study design: </strong>This was a prospective, matched-cohort study with a 1:2 ratio of cases with false-positive cell-free DNA results and controls with low-risk cell-free DNA results that were matched by maternal age and body mass index. Participants were recruited between November 2022 and March 2025 at Monash Health and Monash Ultrasound for Women in Melbourne, Australia. Cytogenetic testing was conducted on 4 biopsies per placenta to investigate confined placental mosaicism. The cases and matched controls were compared using trio matching identifiers as random effect in conditional logistic regression and linear mixed-effects modelling.</p><p><strong>Results: </strong>A total of 60 cases with false-positive cell-free DNA results were matched with 120 controls. Confined placental mosaicism was observed in 20 of the 60 cases (33.3%) and in none of the controls. The prevalence of confined placental mosaicism was highest among those with rare autosomal trisomy (57.9%; 11/19) and monosomy X (75.5%; 3/4) results. Confined placental mosaicism was also observed following common autosomal trisomy results (21.4%; 3/14) and subchromosomal copy number variants (15.8%; 3/19). The median birth weight percentile was significantly lower among instances of confirmed confined placental mosaicism (20.1; interquartile range, 9.9-48.5) than among matched controls (43.5; interquartile range, 17.1-66.1; P=.049); however, there were no statistically significant increases in small-for-gestational-age neonates or other adverse pregnancy outcomes.</p><p><strong>Conclusion: </strong>Confined placental mosaicism is a frequent contributor to false-positive cell-free DNA results, most often for monosomy X and rare autosomal trisomy results. Although the birth weight median percentiles were lower, the outcomes of cell-free DNA-detected confined placental mosaicism in this average-risk cohort were predominantly favorable. VIDEO ABSTRACT.</p>","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":" ","pages":"101887"},"PeriodicalIF":3.1,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145953312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous glucose monitoring in gestational diabetes mellitus: a tool, not a treatment","authors":"Ashley N. Battarbee MD, MSCR","doi":"10.1016/j.ajogmf.2025.101877","DOIUrl":"10.1016/j.ajogmf.2025.101877","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"8 2","pages":"Article 101877"},"PeriodicalIF":3.1,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guideline gaps in emergency cerclage: evidence limitations and future directions.","authors":"Aya Mudrik, Misgav Rottenstreich","doi":"10.1016/j.ajogmf.2025.101889","DOIUrl":"10.1016/j.ajogmf.2025.101889","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":" ","pages":"101889"},"PeriodicalIF":3.1,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145935245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antenatal corticosteroid use at 22 weeks: balancing guideline authority with evidence quality","authors":"Can Ata MD,&nbsp;Ufuk Atlihan MD","doi":"10.1016/j.ajogmf.2025.101822","DOIUrl":"10.1016/j.ajogmf.2025.101822","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"8 1","pages":"Article 101822"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Underlying placental pathology lesions in pregnant individuals with diabetes and decreasing insulin requirements","authors":"Karen TY Wong MD MSc,&nbsp;Shane Khan MD,&nbsp;Alaa Husain MD,&nbsp;Asmaa Alahmadi MD,&nbsp;Youssef Nasr BSc,&nbsp;Dina El Demellawy MD,&nbsp;Ana Werlang MD","doi":"10.1016/j.ajogmf.2025.101826","DOIUrl":"10.1016/j.ajogmf.2025.101826","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"8 1","pages":"Article 101826"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying the benefit of cerclage in singletons without prior spontaneous preterm birth already on vaginal progesterone","authors":"Vincenzo Berghella MD,&nbsp;Rupsa Boelig MD,&nbsp;Gabriele Saccone MD","doi":"10.1016/j.ajogmf.2025.101828","DOIUrl":"10.1016/j.ajogmf.2025.101828","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"8 1","pages":"Article 101828"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in academic research publishing: updates, controversies, and considerations for pregnancy and perinatal research","authors":"Mariam Ayyash MD, MSCR ,&nbsp;Amir Aviram MD ,&nbsp;Nicole Krenitsky MD, MBA ,&nbsp;Timothy Wen MD, MPH ,&nbsp;Vincenzo Berghella MD","doi":"10.1016/j.ajogmf.2025.101885","DOIUrl":"10.1016/j.ajogmf.2025.101885","url":null,"abstract":"<div><div>Artificial intelligence (AI) has rapidly transformed academic writing and publishing, progressing from simple grammar checkers and citation tools to sophisticated large language models capable of generating, synthesizing, and critically evaluating scientific content. A recent advancement in this space is the rise of deep research AI—agentic models that autonomously conduct structured reasoning to produce evidence-backed research outputs. While AI opens vast opportunities to enhance academic productivity, it also introduces significant ethical challenges. The challenge isn’t just to use AI; rather, to use it responsibly. As AI continues to reshape scholarly communication, it must be guided by clear oversight and ethical frameworks. This article explores AI’s expanding role in academic publishing, with a focus on its applications in manuscript preparation, peer review, and quality assessment. It also addresses the growing concerns surrounding authorship, research integrity, and accountability. We additionally outline key considerations unique to obstetrics and maternal–fetal medicine to guide responsible and field-appropriate AI use in perinatal research and publishing. Ultimately, the responsible integration of AI, balanced with human judgment and governed by rigorous standards, will be critical to ensuring both innovation and credibility in academic research.</div></div>","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"8 3","pages":"Article 101885"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to editor regarding “cerclage for short cervix ≤20 mm before 24 weeks in singleton gestations without prior spontaneous preterm birth decreases preterm birth: a meta-analysis of randomized controlled trials using individual patient-level data”","authors":"Camille Blouin MD,&nbsp;Chantale Vachon-Marceau MD,&nbsp;Marie Haudiquet MD,&nbsp;Emmanuel Bujold MD MSc","doi":"10.1016/j.ajogmf.2025.101827","DOIUrl":"10.1016/j.ajogmf.2025.101827","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"8 1","pages":"Article 101827"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to Editor regarding “Randomized, controlled trial of the impact of ursodeoxycholic acid on glycemia in gestational diabetes mellitus: The GUARDS trial”","authors":"Huan Luo MD,&nbsp;Lei Pu PhD","doi":"10.1016/j.ajogmf.2025.101795","DOIUrl":"10.1016/j.ajogmf.2025.101795","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"8 1","pages":"Article 101795"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' Reply re: Randomized, controlled trial of the impact of ursodeoxycholic acid on glycemia in gestational diabetes mellitus: the GUARDS trial","authors":"Catalina De Paco Matallana MD,&nbsp;Kypros H. Nicolaides MD,&nbsp;Catherine Williamson MD","doi":"10.1016/j.ajogmf.2025.101796","DOIUrl":"10.1016/j.ajogmf.2025.101796","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"8 1","pages":"Article 101796"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}