American Journal of Obstetrics & Gynecology Mfm最新文献

{"title":"When the first hour counts: critical transfusion and transient uncontrolled bleeding in placenta accreta spectrum hysterectomy","authors":"Shubhangi Singh MBBS, Lindsay Tremper MD, Christopher DeBarge MD, David E. Arnolds MD, Thomas T. Klumpner MD, Michael Taylor MD, AnneMarie Opipari MD, Shitanshu Uppal MBBS, Aimee Rolston MD, Yuan Yuan MS, Graciela Mentz PhD, Nicholas J. Douville MD, Milo Engoren MD, Shih-Hon Li MD, Carlo Pancaro MD","doi":"10.1016/j.ajogmf.2025.101834","DOIUrl":"10.1016/j.ajogmf.2025.101834","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"8 1","pages":"Article 101834"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145921141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to editor regarding “Next-generation sequencing–based approach for fetal DNA quantification and blood antigen detection in alloimmunized pregnancies”","authors":"Huai-An Yin MD, Yan-Ru Xiao MD","doi":"10.1016/j.ajogmf.2025.101825","DOIUrl":"10.1016/j.ajogmf.2025.101825","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"8 1","pages":"Article 101825"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prepregnancy or delivery BMI? Identifying the better predictor of adverse outcomes","authors":"Raina A. Meka MD, Nandini Raghuraman MS, MSCI, Katherine H. Bligard MA, MD, Alison G. Cahill MD, MSCI, Jeannie C. Kelly MD, MS, Antonina I. Frolova MD, PhD","doi":"10.1016/j.ajogmf.2025.101814","DOIUrl":"10.1016/j.ajogmf.2025.101814","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"8 1","pages":"Article 101814"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal overdiagnosis of placenta accreta spectrum: associated factors and perinatal outcomes","authors":"Olga Grechukhina MD, Colleen Sinnott MD, Khadija Alshowaikh MD, Jennifer Culhane PHD, MPH, Lisbet Lundsberg PHD, MPH, Caitlin Partridge BA, Yang Yang-Hartwich PhD, Mert Ozan Bahtiyar MD, Sonya Abdel-Razeq MD","doi":"10.1016/j.ajogmf.2025.101850","DOIUrl":"10.1016/j.ajogmf.2025.101850","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"8 1","pages":"Article 101850"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145921140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of dental treatments on reduction of preterm birth: a systematic review and meta-analysis","authors":"Camille Thomas MD, MPH ,&nbsp;Shakil Ahmed MPH ,&nbsp;Vincenzo Berghella MD ,&nbsp;Romina Brignardello-Petersen DDS, PhD ,&nbsp;Mohamed El-Rabbany DDS, PhD ,&nbsp;Catherine Devion MLS ,&nbsp;Stefania Ronzoni MD, PhD","doi":"10.1016/j.ajogmf.2025.101884","DOIUrl":"10.1016/j.ajogmf.2025.101884","url":null,"abstract":"<div><h3>Objective</h3><div>Periodontal disease is associated with increased risk of preterm birth. Effective management during pregnancy may reduce preterm birth, though clinical trial evidence has been inconsistent. This study aimed to assess whether treating dental disease during pregnancy reduces preterm birth.</div></div><div><h3>Data Sources</h3><div>A systematic search was performed of EMBASE, MEDLINE, PubMed, Cochrane Library, and trial registries up to December 2023 and re-run in January 2025.</div></div><div><h3>Study Eligibility Criteria</h3><div>Randomized controlled trials (RCTs) enrolling pregnant persons with any dental disease randomized to receive dental treatment vs no treatment were included. No language restriction was applied.</div></div><div><h3>Study Appraisal and Synthesis Methods</h3><div>Data were independently extracted by two researchers and assessed for risk of bias using the Cochrane Risk of Bias tool, RoB 2. A random effect meta-analysis was performed with the Mantel–Haenszel variance estimate. Certainty of evidence (COE) was assessed using GRADE. The main outcome was preterm birth (&lt;37 weeks’ gestation). Data on low birth weight were also collected.</div></div><div><h3>Results</h3><div>Fourteen RCTs (8316 participants) were included. Interventions included scaling and root planing (SRP) alone (8 RCTs), SRP with chlorhexidine mouthwash (4 RCTs), and cetylpyridinium chloride mouthwash (2 RCTs). Meta-analysis and GRADE assessment found moderate-certainty evidence suggesting that periodontal treatment results in a 15% relative risk reduction of preterm birth (risk ratio [RR] 0.85; 95% CI 0.71–1.02) compared to minimal periodontal treatment or no treatment (absolute difference 20 fewer preterm births per 1000 individuals; 95% CI from 39 fewer to 3 more). It is uncertain whether the addition of chlorhexidine mouthwash to SRP reduces preterm birth rates (RR 0.49, 95% CI 0.23–1.04, very low COE).</div></div><div><h3>Conclusion</h3><div>This meta-analysis, the largest and most up-to-date on this topic, suggests that treating periodontal disease during pregnancy may reduce the risk of preterm birth. However, limitations, such as the risk of bias and variations in populations and treatment, highlight the need for well-powered RCTs with low risk of bias to evaluate the most effective dental treatment strategies. Future studies should focus on established dental disease severity and explore different dental treatment strategies, including antimicrobial mouthwash.</div></div>","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"8 3","pages":"Article 101884"},"PeriodicalIF":3.1,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of maternal Mediterranean diet on fetal cardiac function in high-risk pregnancies: a secondary analysis of the IMPACT BCN randomized trial","authors":"Lina Youssef MD, PhD ,&nbsp;Kenny Araujo MD ,&nbsp;Lea Testa MD ,&nbsp;Rommy Helena Novoa MD ,&nbsp;Roger Borras MSc ,&nbsp;Sara Castro-Barquero MD, PhD ,&nbsp;Gabriel Bernardino PhD ,&nbsp;Bart Bijnens MD, PhD ,&nbsp;Francesca Crovetto MD, PhD ,&nbsp;Eduard Gratacos MD, PhD ,&nbsp;Fatima Crispi MD, PhD ,&nbsp;study working group","doi":"10.1016/j.ajogmf.2025.101875","DOIUrl":"10.1016/j.ajogmf.2025.101875","url":null,"abstract":"<div><h3>BACKGROUND</h3><div>Maternal suboptimal nutrition and high stress levels are associated with altered fetal cardiovascular function.</div></div><div><h3>OBJECTIVE</h3><div>This study aimed to assess the effect of structured maternal lifestyle interventions based on a Mediterranean diet or mindfulness-based stress reduction during pregnancy on fetal cardiac function.</div></div><div><h3>STUDY DESIGN</h3><div>This was a secondary analysis of the IMPACT BCN (Improving Mothers for a better PrenAtal Care Trial BarCeloNa) randomized clinical trial, which was conducted at a university hospital in Barcelona, Spain, from February 2017 to March 2020. A total of 1221 singleton pregnancies (19–23 weeks’ gestation) with high risk of delivering small-for-gestational-age newborns were randomly allocated into 3 groups in a 1:1:1 ratio: a Mediterranean diet intervention, a stress reduction program, or usual care. Participants in the Mediterranean diet group received monthly individual and group educational sessions and free provision of extra-virgin olive oil and walnuts. Those in the stress reduction group underwent an 8-week mindfulness-based stress reduction program adapted for pregnancy. Individuals in the usual care group received pregnancy care per institutional protocols. Fetal cardiac function was assessed using cord blood NT-proBNP (N-terminal probrain natriuretic peptide) and fetal echocardiography. NT-proBNP was measured in cord blood collected at delivery and considered high if &gt;90^th centile. Fetal echocardiography was performed at 33 to 34 weeks’ gestation. Data were analyzed from January to July 2024.</div></div><div><h3>RESULTS</h3><div>Fetal echocardiography and cord blood NT-proBNP measurements were obtained in 990 and 746 pregnancies, respectively. Whereas fetuses in the stress reduction group showed similar fetal cardiac results, the proportion of fetuses with high cord blood NT-proBNP concentrations was significantly lower in the Mediterranean diet group (6.4% vs 12%; <em>P</em>=.03) compared with the usual care group. Additionally, fetuses whose mothers followed the Mediterranean diet exhibited higher right ventricular fractional area change (mean [standard deviation], 30.4% [8.3] vs 28.1% [8.9]; <em>P</em>=.03) and thinner myocardial walls (mean [standard deviation], 2.95 [0.55] vs 3.16 [0.58] mm; <em>P</em>=.006) compared with the usual care group.</div></div><div><h3>CONCLUSION</h3><div>Promotion of a maternal Mediterranean diet intervention during pregnancy seems to be associated with a less overloaded and more efficient fetal heart. Future research is warranted to elucidate the mechanism(s) underlying these findings.</div></div>","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"8 2","pages":"Article 101875"},"PeriodicalIF":3.1,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized controlled trial of real-time continuous glucose monitoring (RT-CGM) for self-management of gestational diabetes","authors":"Nicole Ehrhardt MD ,&nbsp;Stephanie J. Fonda PhD ,&nbsp;Patali Mandava MBBS ,&nbsp;Ghada Abdalla MBBCH ,&nbsp;Emily Fay MD","doi":"10.1016/j.ajogmf.2025.101878","DOIUrl":"10.1016/j.ajogmf.2025.101878","url":null,"abstract":"<div><h3>Background</h3><div>Gestational diabetes mellitus (GDM) - a risk factor for adverse pregnancy outcomes - is on the rise. Real-time continuous glucose monitoring (RT-CGM) may enhance glucose control during GDM and thereby improve outcomes; however, more data are needed.</div></div><div><h3>Objective</h3><div>This study aimed to determine if RT-CGM improved glycemic indices in GDM.</div></div><div><h3>Study Design</h3><div>An open-label, randomized controlled trial was conducted with GDM patients diagnosed between 14 and 30 weeks estimated gestational age (EGA), assigning them either to RT-CGM or blinded CGM in addition to self-monitoring of blood glucose (SMBG). This analysis compares CGM metrics for the study groups at EGA of 32 and 36 weeks (± 10 days). The primary outcome was percentage of time in range 63 to 140 mg/dL (TIR) over 24 hours. Secondary outcomes included mean glucose over 10 days and additional CGM indices, HbA1c, diabetes medication usage, satisfaction with CGM, and maternal and fetal outcomes.</div></div><div><h3>Results</h3><div>105 participants with GDM were enrolled (RT-CGM [n=53] or blinded CGM [n=52]) Thirty-one of 52 SMBG participants withdrew, with 30 citing desiring RT-CGM. In participants who completed the study, average EGA was 29.8 weeks (SD=2.5) on their first day of CGM wear with average duration of wear of 64.4 days (SD=19.4). TIR 63-140 mg/dL (TIR) was 93.0 (SD=6.7) and 93.7 (SD=6.8) (<em>p</em>=.86) while mean glucose was 106.7 mg/dL (SD=9.0) and 98.1 mg/dL (SD=13.8) for the RT-CGM and SMBG groups (<em>p</em>=.02), respectively. At study completion, mean glucose and TIR were similar. Insulin and/or metformin use was 66.7% in the RT-CGM group and 33.4% in the SMBG group (<em>p</em>=.02). There were no significant differences in maternal or fetal outcomes. The RT-CGM group’s satisfaction with CGM was high.</div></div><div><h3>Conclusions</h3><div>In this study in which CGM was initiated at about 30 weeks EGA, TIR and mean glucose were similar. However, more participants in the CGM group initiated insulin. Selection and attrition bias could have affected the results. Glycemic changes were minor, but interest in CGM was high. Further research is needed to assess if earlier implementation and use in higher risk populations may provide benefit.</div></div>","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"8 2","pages":"Article 101878"},"PeriodicalIF":3.1,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal positions reduce occiput posterior malposition and improve vaginal birth: a systematic review and meta-analysis of randomized controlled trials","authors":"Meilin Yang MD ,&nbsp;Cheng Zhao MD ,&nbsp;Shaojun Lin MS ,&nbsp;Xiaoyue Guo MD ,&nbsp;Jing Yang MD ,&nbsp;Shenglian Ni BSc ,&nbsp;Yan Zhao MS ,&nbsp;Chunyang Ai MS ,&nbsp;Yangyu Zhao MD","doi":"10.1016/j.ajogmf.2025.101880","DOIUrl":"10.1016/j.ajogmf.2025.101880","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the effect of changing maternal position in late pregnancy and the first stage of labor on rotation from occiput posterior (OP) to occiput anterior (OA) and subsequent maternal-fetal outcomes.</div></div><div><h3>Data sources</h3><div>We systematically searched randomized controlled trials (RCTs) from the databases including PubMed, Embase, and Cochrane Library without language restriction, spanning from their inception to May 11, 2025. Registration PROSPERO (CRD420251050400).</div></div><div><h3>Study eligibility criteria</h3><div>The following PICOS criteria were included:(1) Population (P): singleton pregnancies in late pregnancy (≥37 weeks of gestation) or the first stage of labor. (2) Intervention (I): maternal positions. (3) Comparison (C): non-intervention position or unrestricted maternal activities. (4) Outcomes (O): number of participants who attained OA. (5) Study design (S):RCTs.</div></div><div><h3>Study appraisal and synthesis methods</h3><div>Separate meta-analyses were conducted for all RCTs and for trustworthy RCTs identified using the OBGYN Editors' Integrity Group criteria. Pooled relative risks (RR) and standard mean differences (SMD) with 95% CIs were calculated. Publication bias was assessed.</div></div><div><h3>Results</h3><div>A meta-analysis of four trustworthy RCTs (n=922) from the first stage of labor demonstrated that positional intervention significantly increased OP to OA rotation (pooled RR=1.68, 95% CI=1.09−2.60; I²=66.3%). Moreover, when initiated at 3-5 cm dilation with a prolonged protocol (targeted hourly or continuous duration), the intervention yielded even greater benefits for rotation (pooled RR=2.45, 95% CI=1.63−3.67; I²=0.0%), and also significantly increased rates of both vaginal delivery (pooled RR=1.22, 95% CI=1.06−1.41; I²=0.0%) and spontaneous vaginal delivery (SVD) (pooled RR=1.39, 95% CI=1.05−1.84; I²=0.0%). Consistent benefits persisted in an analysis of all ten RCTs, remaining significant after adjustment for publication bias. Subgroup analyses of these ten RCTs indicated that the lateral position with upper thigh flexed benefited SVD. Additionally, two late-pregnancy studies (n=2647) assessed maternal position for OP fetuses, but methodological differences precluded meta-analysis.</div></div><div><h3>Conclusions</h3><div>Intrapartum maternal position can promote OP to OA rotation and vaginal delivery, but antenatal evidence remains inconclusive and lacking.</div></div>","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"8 3","pages":"Article 101880"},"PeriodicalIF":3.1,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing prenatal counseling and support for parents carrying a fetus with a congenital anomaly: a scoping review of key characteristics and practices","authors":"Neeltje M.T.H. Crombag ,&nbsp;Bente Teeuwen ,&nbsp;Sigrid Teuben ,&nbsp;Nadine A. Kasparian ,&nbsp;Erica Sood ,&nbsp;Bauke M.E. Adriaanse ,&nbsp;Mireille N. Bekker","doi":"10.1016/j.ajogmf.2025.101874","DOIUrl":"10.1016/j.ajogmf.2025.101874","url":null,"abstract":"<div><h3>Objective</h3><div>To identify and synthesize key characteristics of prenatal counseling process and content, and support provided to parents carrying a fetus with a congenital anomaly.</div></div><div><h3>Data sources</h3><div>A scoping review was conducted searching 2 electronic databases (PubMed and Embase) on January 23rd, 2025.</div></div><div><h3>Study eligibility criteria</h3><div>We included original studies on prenatal counseling for fetal anomalies. Eligible populations included parents receiving a fetal anomaly diagnosis, individuals with a congenital anomaly, healthcare professionals involved in prenatal counseling, and patient representatives. Publications had to be in English, Dutch, or German. Reviews without original data were excluded.</div></div><div><h3>Study appraisal and synthesis methods</h3><div>No quality assessment was performed. Extracted data were categorized into counseling process and content, and thematically analyzed.</div></div><div><h3>Results</h3><div>Of the 9028 articles screened, 43 articles met predefined eligibility criteria. The included articles, published between 1995 and 2024, encompassed a range of perspectives, including those of parents, individuals with a congenital anomaly, healthcare professionals, and representatives from patient advocacy groups. Findings were organized into 2 main categories: prenatal counseling process and content. Process themes included: (1) Communication, (2) Multidisciplinary counseling, (3) Shared decision-making, (4) Continuity, (5) Accessibility, (6) Psychosocial support, and (7) Counseling prerequisites. Content themes were: (1) Informational content, and (2) Delivery of information.</div></div><div><h3>Conclusion</h3><div>Results underscore the necessity of a holistic approach to prenatal counseling for parents after fetal diagnosis, and highlight the importance of integrating psychological care alongside information delivery.</div></div>","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"8 2","pages":"Article 101874"},"PeriodicalIF":3.1,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145776098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing a prospective cohort to examine the impact of medication for opioid use disorder in pregnancy","authors":"Courtney Townsel MD, MSc ,&nbsp;Fatemeh Biroon MD ,&nbsp;Eric K. Broni MD ,&nbsp;Makeda D. Turner MS ,&nbsp;Vedavalli Govindan MPS ,&nbsp;Sarah Sabet BS ,&nbsp;Ai A. Tarui BS ,&nbsp;Samantha A.S. Willimas BS ,&nbsp;Jackie M. Goodrich PhD ,&nbsp;Dana C. Dolinoy PhD ,&nbsp;Jeannie C. Kelly MD","doi":"10.1016/j.ajogmf.2025.101866","DOIUrl":"10.1016/j.ajogmf.2025.101866","url":null,"abstract":"<div><h3>Objective</h3><div>To describe the design and initial findings of a prospective cohort study examining the impact of opioid treatment during pregnancy on maternal and infant outcomes.</div></div><div><h3>Study Design</h3><div>A multi-site prospective cohort study of 127 pregnancies (including 3 sets of twins), comprising 86 individuals with medication for opioid use disorder exposure and 41 matched controls. Data collection included structured clinical interviews, medical record abstraction, and biospecimen sampling from maternal and neonatal sources.</div></div><div><h3>Results</h3><div>The cohort is predominantly non-Hispanic White and multiparous. Among opioid-exposed participants, mood disorders, nicotine use, and hepatitis C were common. Over 80% of opioid-exposed infants developed neonatal withdrawal, with nearly half experiencing severe symptoms.</div></div><div><h3>Conclusions</h3><div>High rates of co-occurring conditions were observed among pregnant individuals receiving medication for opioid use disorder. Most opioid-exposed neonates developed neonatal withdrawal. This cohort provides a rich clinical resource for investigating the effects of prenatal opioid exposure on maternal and infant health.</div></div>","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"8 2","pages":"Article 101866"},"PeriodicalIF":3.1,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145744927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}