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Technical Innovations and Patient Support in Radiation Oncology最新文献

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Radiation therapist research capacity and output: a multicentre retrospective study of authorship, collaboration, and institutional strategies (2013–2022) 放射治疗研究能力和产出:作者、合作和机构策略的多中心回顾性研究(2013-2022)
IF 2.8 Q1 Nursing Pub Date : 2025-10-28 DOI: 10.1016/j.tipsro.2025.100351
Caroline Marr , Tara Rosewall , Helen A McNair , Maddalena M.G. Rossi , Yat Tsang

Purpose

Radiation Therapist (RTT) research culture is essential for driving innovation and informing evidence-based practice. This study aimed to assess RTT research output and institutional capacity-building initiatives across international clinical academic cancer centres.

Methods

This was a retrospective analysis of RTT research activities and capacity-building initiatives from 2013 to 2022 at three centres located in Canada (CA), the Netherlands (NL) and the United Kingdom (UK). Data was collected on research output by identifying all RTT author publications (first, second, or senior author). Institutional capacity-building initiatives were captured from each centre and described using full-time equivalents (FTEs). A qualitative analysis was conducted on all RTT publications to identify common research topics.

Results

Over the 10 years, the total number of RTT-authored publications was 445 across the centres (CA:291; UK:79; NL:75). RTTs as first authors ranged from 14.7 % to 44.3 % and RTTs as senior authors ranged from 0 % to 27.8 % of publications. Centres with increasing FTEs demonstrated increasing research productivity, with publications changing from 21 to 34 in CA and from 3 to 15 in the UK centre. Multidisciplinary collaboration was common among all centres. Prominent RTT research themes included technological applications, RTT professional development and quality assurance, clinical outcomes, dosimetry, and patient care. Common strategies to build research capacity included educational initiatives, the creation of dedicated research roles, and promoting research dissemination.

Conclusion

This study highlighted the contributions of RTTs to radiation oncology research and how a comprehensive approach to building research capacity results in high RTT research output and collaboration.
目的放射治疗师(RTT)的研究文化对于推动创新和为循证实践提供信息至关重要。本研究旨在评估国际临床学术癌症中心的RTT研究成果和机构能力建设倡议。方法回顾性分析了2013年至2022年在加拿大(CA)、荷兰(NL)和英国(UK)三个中心开展的RTT研究活动和能力建设活动。通过识别所有RTT作者出版物(第一、第二或高级作者)收集研究产出数据。从每个中心收集机构能力建设倡议,并使用全时等值物加以描述。对所有RTT出版物进行定性分析,以确定共同的研究主题。结果10年间,各中心rtt撰写的出版物总数为445篇(CA:291篇;UK:79篇;NL:75篇)。作为第一作者的rtt占出版物的14.7%至44.3%,作为资深作者的rtt占出版物的0%至27.8%。全职人员增加的中心显示出更高的研究生产力,CA的出版物从21篇增加到34篇,英国中心从3篇增加到15篇。所有中心之间普遍存在多学科合作。主要的RTT研究主题包括技术应用、RTT专业发展和质量保证、临床结果、剂量学和病人护理。建立研究能力的共同战略包括教育倡议、设立专门的研究角色和促进研究传播。结论本研究突出了RTT对放射肿瘤学研究的贡献,以及如何通过综合方法建设研究能力来提高RTT的研究产出和合作。
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引用次数: 0
Monitoring lung tumour volume on daily cone beam CT; is it achievable in a real-world setting? 每日锥束CT监测肺肿瘤体积这在现实世界中是否可行?
IF 2.8 Q1 Nursing Pub Date : 2025-10-23 DOI: 10.1016/j.tipsro.2025.100352
Sarah Barrett , Laure Marignol , Gerard G Hanna , Conor K McGarry , Gerard M Walls
Delineating the gross tumour volume (GTV) in non-small cell lung cancer (NSCLC) can be challenging due to anatomical complexities and imaging artefacts. This study evaluates a semi-automated workflow using commercial software for target volume (TV) delineation on cone-beam CT (CBCT) in patients undergoing radical radiotherapy. Seventy-six patients with 553 scans (n = 76 planning CT, n = 477 CBCT) were included. Auto-contours were adjusted by a senior Radiation Therapist and reviewed for accuracy. The majority (59.1 %) required only minor revisions, with median adjustment time of CBCT auto-contours of 83 (range 0–460) seconds. The findings support the feasibility of this approach, offering a pragmatic solution for adaptive radiotherapy workflows in NSCLC.
由于解剖复杂性和成像伪影,非小细胞肺癌(NSCLC)的总肿瘤体积(GTV)的描绘具有挑战性。本研究评估了在接受根治性放疗的患者中,使用商业软件在锥束CT (CBCT)上进行靶体积(TV)划定的半自动工作流程。纳入76例患者553次扫描(n = 76次计划CT, n = 477次CBCT)。自动轮廓由高级放射治疗师调整,并检查其准确性。大多数(59.1%)只需要轻微的修改,CBCT自动轮廓的中位调整时间为83(范围0-460)秒。研究结果支持该方法的可行性,为非小细胞肺癌的适应性放疗工作流程提供了实用的解决方案。
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引用次数: 0
Advancing proton therapy together: insights on practice, technology, and implementation 共同推进质子治疗:对实践、技术和实施的见解
IF 2.8 Q1 Nursing Pub Date : 2025-10-15 DOI: 10.1016/j.tipsro.2025.100350
Taeyoon Kim, Nicola Bizzocchi
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引用次数: 0
Operational assessment of tattooless breast radiotherapy using AlignRT surface guidance 使用AlignRT表面引导的无纹身乳房放疗的操作评估
IF 2.8 Q1 Nursing Pub Date : 2025-10-12 DOI: 10.1016/j.tipsro.2025.100349
Aria Malhotra , Andrew K.H. Robertson , Ian Sun , Samantha A.M. Lloyd

Background and purpose

Surface guided radiation therapy (SGRT) is a new approach for patient setup that can replace tattoo-based positioning. The permanent body markings that come with this long-standing standard of care can have a lasting negative emotional impact on cancer survivors. This study evaluates surface guidance as an alternative positioning modality, comparing speed, accuracy, and cost of the two techniques.

Methods

Setup time and positional accuracy prior to radiographic localization for patients receiving radiation therapy for breast cancer were compared between two linear accelerators, one with and one without surface guidance technology. A Wilcoxon rank sum test was used to determine statistically significant differences in setup time and positional shifts. Cost projections per fraction and per patient for both modalities were conducted.

Results

SGRT positional accuracy and setup time were equivalent to or better than tattoo-based setup. SGRT setup was faster for all photon treatments by 11 s. Deep inspiration breath hold setup times were equivalent for both positioning modalities, but SGRT was faster by 23 s for free breathing setups. There were no statistically significant differences in the magnitude of positional shifts on pre-treatment imaging. SGRT costs are broken down into item costs and staffing costs, with final estimates dependent on a center’s capacity for treatments per day.

Conclusions

Surface guided patient positioning for breast radiotherapy is fiscally feasible and non-inferior to permanent tattoos in terms of set up time and accuracy.
背景与目的表面引导放射治疗(SGRT)是一种新的病人定位方法,可以取代纹身定位。伴随这种长期标准护理而来的永久性身体标记可能会对癌症幸存者产生持久的负面情绪影响。本研究评估了地面制导作为另一种定位方式,比较了两种技术的速度、精度和成本。方法比较两种线性加速器加表面引导技术和不加表面引导技术对乳腺癌放疗患者定位前的设置时间和定位精度。使用Wilcoxon秩和检验来确定设置时间和位置移位的统计学显著差异。对两种模式进行了每个分数和每个患者的成本预测。结果ssgrt定位精度和设置时间等于或优于纹身设置。所有光子处理的SGRT设置都快了11秒。两种体位方式的深度吸气屏气设置时间相同,但自由呼吸设置的SGRT快23秒。在治疗前影像学上,位置移位的大小没有统计学上的显著差异。SGRT成本分为项目成本和人员成本,最终的估计取决于一个中心每天的治疗能力。结论表面引导患者体位在乳腺放疗中经济可行,且在设置时间和准确性上不逊色于永久性文身。
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引用次数: 0
Three-year insights from a proton therapy centre: Evolving strategies in ependymoma treatment planning 质子治疗中心三年的见解:室管膜瘤治疗计划的发展策略
IF 2.8 Q1 Nursing Pub Date : 2025-10-06 DOI: 10.1016/j.tipsro.2025.100347
Lieselotte Lauwens , Anneleen Goedgebeur , Tom Boterberg , Tom Depuydt , Dario Di Perri , Lorraine Donnay , Benjamin Ledoux , Kenneth Poels , Susana Santos Lopes , Karen Van Beek , Robin De Roover , Maarten Lambrecht

Background

Treatment of posterior fossa ependymoma with proton therapy (PT) is challenging due to the proximity to the brainstem and potential risk of brainstem toxicity.

Materials and methods

This retrospective study included patients with intracranial ependymoma treated with PT or a hybrid proton–photon (PT-XT) approach at our centre between July 2020 and December 2023 with a minimum 12 month follow-up. Treatment approach was determined based on tumour relationship to the brainstem. Patient and tumour characteristics and treatment planning approaches were evaluated, and dosimetric data between PT and PT-XT approaches were compared. Outcomes including symptomatic brainstem injury (SBI) and asymptomatic radiographic changes (ARC) were assessed.

Results

Fourteen patients were included, of which nine had posterior fossa ependymoma, with five treated using a hybrid PT-XT planning approach and four with PT alone. The hybrid PT-XT approach involved delivering 75 % of the treatment (0–45 Gy(RBE)) with PT and the remaining portion (45–59.4 Gy) with XT, addressing concerns regarding increased relative biological effectiveness of PT in the brainstem. While all plans adhered to the European Particle Therapy Network D0.03cc brainstem dose constraint, the University of Florida constraints were not always met. Comparison of the hybrid PT-XT and PT-only replans showed a trend towards improved brainstem dose parameters with the hybrid approach. After a median follow-up of 22.2 months, no patients developed symptomatic brainstem injury and three showed asymptomatic radiographic changes.

Conclusion

Tailored planning approaches, depending on location and relationship to the brainstem, are essential when treating ependymoma patients. A hybrid PT-XT approach, is feasible in well-selected patients, demonstrating acceptable target coverage, brainstem doses, and to date no occurrence of symptomatic brainstem injury.
背景:质子治疗后窝室管膜瘤(PT)具有挑战性,因为它靠近脑干并且有脑干毒性的潜在风险。材料和方法本回顾性研究纳入了2020年7月至2023年12月在我们中心接受PT或混合质子-光子(PT- xt)入路治疗的颅内室管膜瘤患者,随访至少12个月。根据肿瘤与脑干的关系确定治疗方法。评估患者和肿瘤特征和治疗计划方法,并比较PT和PT- xt方法之间的剂量学数据。评估结果包括症状性脑干损伤(SBI)和无症状放射学改变(ARC)。结果纳入14例患者,其中9例为后窝室管膜瘤,5例采用PT- xt混合方案治疗,4例单独采用PT治疗。PT-XT混合方法包括75%的治疗(0-45 Gy(RBE))用PT,其余部分(45-59.4 Gy)用XT,解决了PT在脑干中相对生物学有效性增加的问题。虽然所有计划都遵守欧洲粒子治疗网络D0.03cc脑干剂量限制,但佛罗里达大学的限制并不总是得到满足。混合PT-XT和单独pt重新计划的比较显示,混合方法有改善脑干剂量参数的趋势。中位随访22.2个月后,无患者出现症状性脑干损伤,3例出现无症状的影像学改变。结论在治疗室管膜瘤患者时,根据其位置和与脑干的关系,有针对性地规划方法是必不可少的。混合PT-XT方法在精心选择的患者中是可行的,显示出可接受的靶标覆盖率和脑干剂量,并且迄今未发生症状性脑干损伤。
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引用次数: 0
Evaluating participant experiences and tolerability with MR Linac imaging 评估参与者的经验和耐受性与磁共振直线成像
IF 2.8 Q1 Nursing Pub Date : 2025-10-03 DOI: 10.1016/j.tipsro.2025.100348
Jayde Nartey , Helen A. McNair , Katie Biscombe , Sophie E. Alexander , Charlotte Cherry , Cynthia Eccles , Trina Herbert , Shaista Hafeez , Kelly Jones , Francesca Mason , Simeon Nill , Hosna Mohammad , Kian Morrison , Bethany Williams , Robert Huddart

Introduction

Magnetic Resonance Image Guided Radiotherapy (MRIgRT) integrates MRI with a linear accelerator to enable adaptive treatment delivery. While technical feasibility is well established, patient experience during MR Linac imaging, especially outside treatment sessions, remains underexplored. This study evaluates tolerability, pre-scan anxiety, coping ability, willingness for future scans, and scan-induced symptoms in patients and non-patient volunteers.

Materials and Methods

Participants who successfully underwent MR Linac imaging between November 2017 and December 2023 completed a bespoke MR Linac Participant Experience Questionnaire, developed by the PRIMER study team and informed by MRI patient experience literature. The questionnaire assessed pre-scan anxiety, coping, willingness for future scans, and scan-related symptoms using Likert-scale responses. Descriptive analyses summarised responses by participant group and anatomical site.

Results

In total, 447 participants (319 patients; 128 non-patient volunteers) completed MR Linac imaging and the questionnaire. Overall tolerability was high, with 65 % strongly disagreeing they felt anxious prior to scanning and most participants reporting good coping ability. Variability was observed across anatomical sites: Participants undergoing head and neck, brain, and oligometastatic bone scans reported higher pre-scan anxiety, with coping difficulties most frequently reported by the head and neck group. Non-patient volunteers reported more physiological symptoms (e.g., sweating, nausea, dizziness) than patients, whereas patients undergoing head and neck and bone oligometastases scans were more reluctant to repeat the procedure. Most patients perceived MR Linac imaging as easier or comparable to diagnostic MRI, though 20 % of brain cancer patients found it more difficult.

Conclusion

MR Linac imaging is generally well tolerated, though specific subgroups, particularly those requiring immobilisation, report greater anxiety and discomfort. These findings highlight the need for tailored strategies to improve patient experience, supporting wider implementation of MRIgRT.
磁共振图像引导放射治疗(MRIgRT)将MRI与线性加速器集成在一起,以实现自适应治疗递送。虽然技术上的可行性已经确立,但在磁共振直线成像期间的患者体验,特别是在治疗期间,仍未得到充分探索。本研究评估了患者和非患者志愿者的耐受性、扫描前焦虑、应对能力、对未来扫描的意愿以及扫描引起的症状。材料和方法在2017年11月至2023年12月期间成功接受MR Linac成像的参与者完成了一份定制的MR Linac参与者体验问卷,该问卷由PRIMER研究团队开发,并根据MRI患者体验文献提供信息。问卷评估扫描前的焦虑、应对、对未来扫描的意愿以及使用李克特量表反应的扫描相关症状。描述性分析总结了参与者组和解剖部位的反应。结果共有447名参与者(319名患者,128名非患者志愿者)完成了MR Linac成像和问卷调查。总体容忍度很高,65%的人强烈不同意他们在扫描前感到焦虑,大多数参与者报告了良好的应对能力。不同解剖部位观察到差异:接受头颈部、脑部和少转移性骨扫描的参与者报告了更高的扫描前焦虑,头颈部组最常报告应对困难。非患者志愿者比患者报告了更多的生理症状(如出汗、恶心、头晕),而接受头颈部和骨少转移扫描的患者更不愿意重复该程序。大多数患者认为MR直线成像比诊断性MRI更容易或相当,尽管20%的脑癌患者认为它更困难。结论:mr直线成像通常耐受性良好,但特定亚组,特别是需要固定的亚组,报告更大的焦虑和不适。这些发现强调需要量身定制的策略来改善患者体验,支持更广泛地实施MRIgRT。
{"title":"Evaluating participant experiences and tolerability with MR Linac imaging","authors":"Jayde Nartey ,&nbsp;Helen A. McNair ,&nbsp;Katie Biscombe ,&nbsp;Sophie E. Alexander ,&nbsp;Charlotte Cherry ,&nbsp;Cynthia Eccles ,&nbsp;Trina Herbert ,&nbsp;Shaista Hafeez ,&nbsp;Kelly Jones ,&nbsp;Francesca Mason ,&nbsp;Simeon Nill ,&nbsp;Hosna Mohammad ,&nbsp;Kian Morrison ,&nbsp;Bethany Williams ,&nbsp;Robert Huddart","doi":"10.1016/j.tipsro.2025.100348","DOIUrl":"10.1016/j.tipsro.2025.100348","url":null,"abstract":"<div><h3>Introduction</h3><div>Magnetic Resonance Image Guided Radiotherapy (MRIgRT) integrates MRI with a linear accelerator to enable adaptive treatment delivery. While technical feasibility is well established, patient experience during MR Linac imaging, especially outside treatment sessions, remains underexplored. This study evaluates tolerability, pre-scan anxiety, coping ability, willingness for future scans, and scan-induced symptoms in patients and non-patient volunteers.</div></div><div><h3>Materials and Methods</h3><div>Participants who successfully underwent MR Linac imaging between November 2017 and December 2023 completed a bespoke MR Linac Participant Experience Questionnaire, developed by the PRIMER study team and informed by MRI patient experience literature. The questionnaire assessed pre-scan anxiety, coping, willingness for future scans, and scan-related symptoms using Likert-scale responses. Descriptive analyses summarised responses by participant group and anatomical site.</div></div><div><h3>Results</h3><div>In total, 447 participants (319 patients; 128 non-patient volunteers) completed MR Linac imaging and the questionnaire. Overall tolerability was high, with 65 % strongly disagreeing they felt anxious prior to scanning and most participants reporting good coping ability. Variability was observed across anatomical sites: Participants undergoing head and neck, brain, and oligometastatic bone scans reported higher pre-scan anxiety, with coping difficulties most frequently reported by the head and neck group. Non-patient volunteers reported more physiological symptoms (e.g., sweating, nausea, dizziness) than patients, whereas patients undergoing head and neck and bone oligometastases scans were more reluctant to repeat the procedure. Most patients perceived MR Linac imaging as easier or comparable to diagnostic MRI, though 20 % of brain cancer patients found it more difficult.</div></div><div><h3>Conclusion</h3><div>MR Linac imaging is generally well tolerated, though specific subgroups, particularly those requiring immobilisation, report greater anxiety and discomfort. These findings highlight the need for tailored strategies to improve patient experience, supporting wider implementation of MRIgRT.</div></div>","PeriodicalId":36328,"journal":{"name":"Technical Innovations and Patient Support in Radiation Oncology","volume":"36 ","pages":"Article 100348"},"PeriodicalIF":2.8,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145269092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidental dose to internal mammary nodes in post-operative radiation therapy for breast cancer 乳腺癌术后放疗对乳腺内淋巴结的附带剂量
IF 2.8 Q1 Nursing Pub Date : 2025-09-27 DOI: 10.1016/j.tipsro.2025.100346
L.Di Lena , A.W.M. Nielsen , C.P.L. Fulcheri , M. Marcantonini , I. Palumbo , S. Saldi , V. Bini , B.V. Offersen , C. Aristei

Aims

The incidental dose to the internal mammary nodes (IMN) is understudied in patients treated with newer radiation therapy (RT) techniques. The aim of this study was to quantify the incidental IMN dose in a series of breast cancer (BC) patients receiving post-operative RT to the chest wall/breast and regional nodes (level III-IV).

Methods

We retrospectively analyzed data from 95 high-risk BC patients treated between 2015 and 2022. Patients received RT (50 Gy/25fr or 40.05 Gy/15fr) to the breast/chest wall and nodal levels III-IV after mastectomy or breast conserving surgery (BCS). Exclusion criteria were IMN irradiation and pre-operative systemic therapy. One radiation oncologist contoured the CTV_IMN according to ESTRO guidelines and divided it into four sub-regions based on intercostal spaces (ICS): IMNupper, ICS1, ICS2, ICS3. Dosimetric parameters collected were Dmean, V90, V95, D90, and D95. The Dmean was correlated to tumor laterality and location, type of surgery and reconstruction, RT technique (3D-CRT, IMRT, helical RT) and boost.

Results

Mean Dmean to IMN was 71.4 % (range 19.6–118.6) of the prescription dose. Among sub-region, ICS2 and ICS3 received significantly higher doses than ICS1 and IMN upper (p = 0.04). V90 of over 90 % was achieved in only 4/95 patients, 3 were treated with helical RT, and the other with IMRT. The mean V95 and V90 were 15.4 % and 26.2 % respectively. Univariate analysis showed that mastectomy (p = 0.002), omission of boost (p = 0.001), and helical RT (p < 0.0001) were associated with significantly higher IMN Dmean. No significant correlation emerged with laterality, tumor location and type of reconstruction.

Conclusions

In our series, incidental IMN doses were highest after mastectomy and with helical RT delivery, possibly due to more medial margin in chest wall delineation and the helical dose distribution. Nevertheless, incidental doses to the IMN were below recommended doses, thus highlighting the need for IMN contouring when identified as targets.
目的对接受新型放射治疗(RT)的患者的乳腺内淋巴结(IMN)的偶发剂量进行了研究。本研究的目的是量化一系列乳腺癌(BC)患者术后接受胸壁/乳房和区域淋巴结RT (III-IV级)的偶发IMN剂量。方法回顾性分析2015年至2022年间接受治疗的95例高危BC患者的资料。患者在乳房切除术或保乳手术(BCS)后接受放射治疗(50 Gy/25fr或40.05 Gy/15fr)至乳腺/胸壁和淋巴结III-IV级。排除标准为IMN照射和术前全身治疗。一位放射肿瘤学家根据ESTRO指南绘制了CTV_IMN的轮廓,并根据肋间隙(ICS)将其分为四个子区域:IMNupper, ICS1, ICS2, ICS3。收集的剂量学参数为Dmean、V90、V95、D90和D95。Dmean与肿瘤的侧边和位置、手术类型和重建、RT技术(3D-CRT、IMRT、螺旋RT)和boost相关。结果该药对IMN的平均值为处方剂量的71.4%(范围19.6 ~ 118.6)。在次区域中,ICS2和ICS3的剂量显著高于ICS1和IMN上限(p = 0.04)。只有4/95例患者的V90达到90%以上,其中3例采用螺旋RT, 1例采用IMRT。V95和V90的平均值分别为15.4%和26.2%。单因素分析显示,乳房切除术(p = 0.002)、未行助推术(p = 0.001)和螺旋RT (p < 0.0001)与较高的IMN Dmean相关。与侧位、肿瘤位置和重建类型无显著相关性。结论在我们的研究中,乳房切除术和螺旋放射治疗后的偶发放射剂量最高,这可能是由于胸壁描画更内侧边缘和螺旋剂量分布所致。然而,IMN的偶然剂量低于建议剂量,因此,当确定为目标时,强调需要对IMN进行轮廓。
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引用次数: 0
A prospective audit of thoracic reirradiation practice and peer-review in a high-volume academic center 在一个大容量学术中心的胸部再照射实践和同行评议的前瞻性审计
IF 2.8 Q1 Nursing Pub Date : 2025-09-17 DOI: 10.1016/j.tipsro.2025.100345
Geraldine Murphy , Daniel Tong , Grace Wu , B.C. John Cho , Meredith Giuliani , Andrew Hope , Benjamin H. Lok , Alexander Sun , Jean-Pierre Bissonnette , Andrea Bezjak

Background

Reirradiation is an increasingly common challenge with limited prospective evidence to guide practice, which varies internationally. This paper presents the patterns of practice in thoracic reirradiation within a high-volume academic center.

Methods

Thoracic reirradiation cases, discussed at the thoracic radiotherapy quality assurance (QA) meeting, were prospectively collected over 12 months between April 2024 and March 2025. Data collected included patient demographics, primary tumor site, details of previous and current planned radiotherapy, the extent and type of overlap and any treatment plan modifications. The data was analyzed using descriptive statistics.

Results

85 (18.2 % of 466 cases) reirradiation cases were identified at 26 QA meetings. Most reirradiation plans (68.2 %) were of radical intent, with dose overlap (89.4 %, n = 76). Challenges included unreliable registration of prior radiotherapy datasets (16.5 %) and deciding appropriate plan modifications to improve safety: 24.7 % optimized dose distribution to an OAR, 23.5 % involved dose reductions from standard prescriptions and 15.3 % compromised target volume coverage. The most frequently identified dose-limiting OARs were the proximal bronchial tree, esophagus, and spinal cord. Concerns about a lack of normal tissue recovery arose in 7.1 % of cases. In 10.6 % of cases there was explicit discussion of a dose discount for OARs for presumed partial tissue recovery. Peer-review prompted revision of the treatment plan in 11.8 % of cases.

Conclusion

These findings underscore the complexity of thoracic reirradiation and highlight the need for further guidance in the area and the role of QA rounds in optimizing safety and treatment decisions while best practice remains uncertain.
背景辐射是一个日益普遍的挑战,指导实践的前瞻性证据有限,国际上各不相同。本文介绍了在一个高容量学术中心进行胸部再照射的实践模式。方法前瞻性收集2024年4月至2025年3月12个月内胸部放疗质量保证(QA)会议讨论的胸部再放疗病例。收集的数据包括患者人口统计学、原发肿瘤部位、既往和当前计划放疗的详细情况、重叠的程度和类型以及任何治疗计划修改。采用描述性统计对数据进行分析。结果26次质量保证会议共确定再照射病例85例(18.2%)。大多数再照射计划(68.2%)为根治目的,剂量重叠(89.4%,n = 76)。挑战包括先前放疗数据集的不可靠登记(16.5%)和决定适当的计划修改以提高安全性:24.7%优化剂量分配到OAR, 23.5%涉及从标准处方中减少剂量,15.3%涉及目标体积覆盖。最常见的剂量限制性桨叶是近端支气管树、食道和脊髓。7.1%的病例担心缺乏正常组织恢复。在10.6%的病例中,明确讨论了为假定的部分组织恢复使用桨叶的剂量折扣。11.8%的病例因同行评议而修改了治疗方案。结论这些发现强调了胸部再照射的复杂性,强调了在最佳实践尚不确定的情况下,需要进一步指导该领域以及QA轮次在优化安全性和治疗决策中的作用。
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引用次数: 0
Patient perspectives on participation in the Danish Breast Cancer Group Proton Trial: A qualitative research study 丹麦乳腺癌组质子试验中患者参与的观点:一项定性研究
IF 2.8 Q1 Nursing Pub Date : 2025-09-14 DOI: 10.1016/j.tipsro.2025.100344
Kristine W. Høgsbjerg , Anne W. Kristensen , Mette Møller , Else Maae , Maja V. Maraldo , Louise W. Matthiessen , Sami Al-Rawi , Mette H. Nielsen , Cai Grau , Birgitte V. Offersen

Background and purpose

Participation in clinical trials is essential to advancing oncological treatments, yet equitable trial access remains challenging. Diverse patient inclusion strengthens external validity and enhances the generalisability of trial outcomes. However, barriers to trial participation persist, and the factors influencing patient enrolment are not fully understood. This study investigates the patient perspective on participation in the Danish Breast Cancer Group (DBCG) Proton Trial.

Materials and methods

Patients eligible for the DBCG Proton Trial were invited to participate in interviews. Patients were selected to ensure geographical and perspective-based diversity, including randomised and non-randomised patients from eight radiotherapy clinics in Denmark. Semi-structured interviews were conducted via telephone, transcribed, and analysed using an inductive approach to identify the patient perspective on trial participation.

Results

A total of fifteen patients were interviewed. The analysis identified five themes encompassing patients’ motivators and barriers to trial participation: distance to the treatment facility, timing of trial information, decisional support, clinical equipoise and patient needs. These factors were reported by both randomised and non-randomised patients.

Interpretation

Participation in the DBCG Proton Trial was determined by both logistical and personal factors. Distance to the proton treatment facility was the most important barrier, while the potential for reduced late effects was the main motivator. The decision was difficult for most patients, often guided by one dominant concern rather than a balanced consideration of multiple factors. These findings suggest that improved trial communication, decisional support, and attention to geographical barriers are essential for promoting equitable participation in clinical trials.
背景和目的参与临床试验对推进肿瘤治疗至关重要,但公平的试验准入仍然具有挑战性。多样化的患者纳入加强了外部有效性,提高了试验结果的普遍性。然而,参与试验的障碍仍然存在,影响患者入组的因素尚未完全了解。本研究调查了患者参与丹麦乳腺癌组质子试验(DBCG)的观点。材料和方法入选DBCG质子试验的患者被邀请参加访谈。选择患者以确保地理和基于视角的多样性,包括来自丹麦8个放疗诊所的随机和非随机患者。通过电话进行半结构化访谈,记录并使用归纳方法进行分析,以确定患者对试验参与的看法。结果共访谈15例患者。分析确定了五个主题,包括患者参与试验的动机和障碍:与治疗设施的距离、试验信息的时间、决策支持、临床平衡和患者需求。随机分组和非随机分组的患者均报告了这些因素。参与DBCG质子试验是由后勤和个人因素决定的。与质子治疗设施的距离是最重要的障碍,而减少后期效应的潜力是主要的激励因素。对大多数患者来说,决定是困难的,通常是由一个主要的问题引导,而不是多种因素的平衡考虑。这些发现表明,改善试验沟通、决策支持和关注地理障碍对于促进公平参与临床试验至关重要。
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引用次数: 0
Beyond the first course: Re-irradiation practices in Ontario — Insights from a provincial survey 超越第一课程:安大略省的再照射实践-来自省级调查的见解
IF 2.8 Q1 Nursing Pub Date : 2025-09-04 DOI: 10.1016/j.tipsro.2025.100343
Brian Liszewski , Timothy P Hanna , Nareesa Ishmail , Kyle Malkoske , Laura D’Alimonte , Jason Pantarotto , Eric Gutierrez , Julie Kraus , Angelica Ramprashad , Kristin Berry
Re-irradiation is an increasingly important aspect of cancer care, as more patients undergo more complex, multi-course radiation therapy, often across multiple cancer centres. To better understand how re-irradiation is planned and delivered, Ontario Health (Cancer Care Ontario)’s Radiation Treatment Program conducted a provincial review using administrative data and a structured survey of all 15 Regional Cancer Centres (RCC) that provide all radiation therapy to Ontario’s 16 million people. The findings offered insight into current practices, including institutional policies, clinical workflows, technical planning methods, and interprofessional collaboration. As the complexity of care continues to grow, there is a clear need to harmonize these elements across institutions to support the safe, effective, and consistent delivery of re-irradiation. These findings are helping inform system-wide efforts to strengthen coordination and improve quality across the RCCs within Ontario.
随着越来越多的患者接受更复杂、多疗程的放射治疗,通常在多个癌症中心进行,再放射治疗是癌症治疗中越来越重要的一个方面。为了更好地了解再照射是如何计划和实施的,安大略健康(安大略癌症护理)的放射治疗项目利用行政数据和对所有15个区域癌症中心(RCC)进行了一次省级审查,这些中心为安大略1600万人提供所有放射治疗。研究结果提供了对当前实践的见解,包括机构政策、临床工作流程、技术规划方法和专业间合作。随着护理的复杂性不断增加,显然需要协调各机构之间的这些要素,以支持安全、有效和一致地提供再照射。这些发现有助于为全系统加强协调和提高安大略省rcc质量的努力提供信息。
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Technical Innovations and Patient Support in Radiation Oncology
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