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Letter to “Comparing the Lifestyle and Sexual Satisfaction of Patients Received Methadone Maintenance Therapy with Those of Patients Received and Narcotics Anonymous” 致“接受美沙酮维持治疗的患者与接受麻醉匿名患者的生活方式和性满意度比较”的信
Q4 Medicine Pub Date : 2018-06-27 DOI: 10.5812/MEJRH.80738
Saeid Komasi
Letter to “Comparing the Lifestyle and Sexual Satisfaction of Patients Received Methadone Maintenance Therapy with Those of Patients Received and Narcotics Anonymous” Saeid Komasi * Lifestyle Modification Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran Corresponding author: Saeid Komasi, Lifestyle Modification Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Zakarya Razi Blvd., Kermanshah, Iran, Tel/Fax: +98-8334276299, E-mail: s_komasi63@yahoo.com
致“接受美沙酮维持治疗的患者与接受麻醉匿名患者的生活方式和性满意度比较”伊朗克尔曼沙赫医学科学大学伊玛目礼萨医院Saeid Komasi*生活方式改变研究中心通讯作者:Saeid Komasi,生活方式改变研究中心,伊玛目礼萨医院,克尔曼沙医学科学大学,伊朗克尔曼沙Zakarya Razi大道,电话/传真:+98-8334276299,电子邮件:s_komasi63@yahoo.com
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引用次数: 0
A Review of Divided Attention Dysfunction in Alzheimer’s Disease 阿尔茨海默病中注意力分散障碍的研究进展
Q4 Medicine Pub Date : 2018-06-26 DOI: 10.5812/MEJRH.64738
S. S. Mirahadi, Seyyed Ahmad Reza Khatoonabadi, Fatemeh Fekar Gharamaleki
Context: Divided attention is impaired in the early stages of Alzheimer’s disease (AD). The influence of divided attention on people with AD has been considered from different perspectives, such as motor ability, cortical responses, performance in divided attention evaluation tasks, and comparison of divided attention and directed and focused attention. The purpose of the current study was to investigate divided attention in AD patients from these different perspectives. Evidence Acquisition: An electronic search was performed in January and February 2016 in PubMed, Science Direct, Medline, Scopus, Google Scholar, and Ovid databases to obtain relevant articles published from 1980 to 2015. The keywords used included “Alzheimer’s disease”, “attention”, and “divided attention”. The articles obtained were studied using the following standard protocol for inclusion criteria written in the English language, the focus of studies was on divided attention in AD, and no other types of cognitive ability. From the 60 articles found, 10 articles that were adhered to the inclusion criteria were selected for consideration. Results: The 10 studies reviewed considered divided attention in AD from different domains. These domains showed that AD patients had impaired performance in tasks that required divided attention and showed deficits in motor tasks stemming from the negative effects of impaired divided attention on motor ability. Different types of brain deficits have been observed in neuroimaging techniques in individuals with AD during divided attention tasks. Those with AD showed greater impairment for divided attention than for directed and focused attention. Conclusions: Divided attention influences the lives of those with AD from several perspectives. These include the inability to focus on two or several relevant stimuli simultaneously that require divided attention rather than directed and focused attention and a deficit in the performance of motor tasks such as gait and other problems in daily life, such as falling. In addition, depression also had a negative effect on divided attention. Depressed AD patients had more difficulty in daily activities than AD patients without depression. The areas of the brain involved in divided attention in individuals with AD differ from those involved in unaffected people.
背景:注意力分散在阿尔茨海默病(AD)的早期阶段受到损害。从不同的角度考虑了分散注意力对AD患者的影响,如运动能力、皮层反应、在分散注意力评估任务中的表现,以及分散注意力与定向和集中注意力的比较。本研究的目的是从这些不同的角度调查AD患者的注意力分散。证据获取:2016年1月和2月在PubMed、Science Direct、Medline、Scopus、Google Scholar和Ovid数据库中进行了电子搜索,以获取1980年至2015年发表的相关文章。使用的关键词包括“阿尔茨海默病”、“注意力”和“分散注意力”。所获得的文章是使用以下用英语编写的纳入标准的标准方案进行研究的,研究的重点是AD患者的注意力分散,而不是其他类型的认知能力。从发现的60篇文章中,选择了10篇符合纳入标准的文章进行审议。结果:回顾的10项研究认为AD的注意力来自不同领域。这些领域表明,AD患者在需要分散注意力的任务中表现受损,并且由于分散注意力受损对运动能力的负面影响,在运动任务中表现出缺陷。在AD患者的神经成像技术中,在分散注意力任务中观察到了不同类型的大脑缺陷。AD患者在分散注意力方面比在定向和集中注意力方面表现出更大的损伤。结论:注意力分散从多个方面影响AD患者的生活。其中包括无法同时关注两个或几个需要分散注意力而不是定向和集中注意力的相关刺激,以及步态等运动任务的表现不足和日常生活中的其他问题,如跌倒。此外,抑郁对注意力分散也有负面影响。抑郁症AD患者的日常活动比没有抑郁症的AD患者更困难。AD患者大脑中参与注意力分散的区域与未受影响的人不同。
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引用次数: 2
Relationship Between Work-Family Conflict and Job Satisfaction of Medical Staff after Implementing the Health System Development Plan 实施卫生系统发展规划后医务人员工作-家庭冲突与工作满意度的关系
Q4 Medicine Pub Date : 2018-06-26 DOI: 10.5812/MEJRH.57141
H. Habibian, Masoudeh Babakhanian, Gholamreza Mohammadi, Faezeh Deljo, Zeinab Safarian Moradabad, Nasrin Rezazadeh Darvishbaghal, M. Asadian
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引用次数: 1
Job Burnout Among Iranian Speech and Language Pathologists 伊朗言语和语言病理学家的职业倦怠
Q4 Medicine Pub Date : 2018-06-23 DOI: 10.5812/MEJRH.64374
Fatemeh Kasbi, Shohre Kaviani, Maryam Mokhlessin, L. Monshizadeh, R. Noruzi, N. Kia
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引用次数: 3
Inhibitory Effects of Silica Nanoparticles Loaded with Hematoporphyrin on Breast Cancer Cell Line 负载血卟啉的二氧化硅纳米粒子对乳腺癌症细胞株的抑制作用
Q4 Medicine Pub Date : 2018-06-23 DOI: 10.5812/MEJRH.64843
A. Khaleghian, H. Hasanzadeh, Abdolvahab Moshtaghian, Reza Nasr, Alireza Emadi, Shima Moshfegh
Background: Cancer is one of the main causes of death in the world. In recent years, many studies have been conducted on the usage of nanomaterials in cancer treatment. In previous studies, the anti-tumor effects of mesoporous silica nanoparticles (MSN) on cancer cells have been shown. The aim of this study was to evaluate the effect of MSN loaded with Hematoporphyrin (HpD) on the cell proliferation and invasion of MCF7 (Michigan Cancer Foundation-7) breast cancer cell line. The antioxidant effects of MSN loaded with HpD were also investigated. Methods: In this study, using MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay, the proliferation and viability of cancer cells were studied after exposure to MSN loaded with HpD. The wound healing assay technique (migration test) was used for the assessment of cancer cells’ invasion. The antioxidant effects of MSN loaded with HpD were studied by DPPH (2,2-diphenyl-1-picrylhydrazyl) assay and FRAP (ferric reducing/antioxidant power) assay techniques. Results: Our results showed that the viability and proliferation of breast cancer cell line MCF7 in the presence of silica nanoparticles loaded with hematoporphyrin (HpD) significantly declined (P = 0.02). After exposure to mesoporous silica nanoparticles (MSN) loaded with hematoporphyrin (HpD), the cancer cell invasion decreased (P = 0.025). Silica nanoparticles alone and loaded with hematoporphyrin (HpD) showed considerable cytotoxic activities against cancer cell lines (IC50 = 20 - 30 μg.mL-1). The most promising result was achieved for MSN loaded with hematoporphyrin (HpD) with the minimum IC50 value. It was found that the proliferation rate of MCF7 cells decreased after treatment with this compound in a dose-dependent manner. The assessments with DPPH assay and FRAP assay techniques showed that MSN and MSN loaded with HpD have antioxidant activities. Conclusions: MSN loaded with HpD have an inhibitory effect on the growth of the MCF7 cell line. MSN alone and in combination with HpD have an inhibitory effect on cell invasion in the MCF7 cell line. MSN alone and loaded with HpD have antioxidant effects. These results indicate that MSN has the potential to be used in cancer treatment as a carrier for anticancer drugs. Keywords: Silica Nanoparticles; Hematoporphyrin; Cell Viability; Invasion; Antioxidant; Breast Cancer; Cell Line
背景:癌症是世界上主要的死亡原因之一。近年来,对纳米材料在癌症治疗中的应用进行了许多研究。在先前的研究中,介孔二氧化硅纳米颗粒(MSN)对癌症细胞的抗肿瘤作用已经得到证实。本研究旨在评估含血卟啉(HpD)的MSN对MCF7(密歇根癌症基金会-7)癌症细胞系细胞增殖和侵袭的影响。研究了HpD负载MSN的抗氧化作用。方法:采用MTT法[3-(4,5-二甲基噻唑-2-基)-2,5-二苯基溴化四唑鎓]测定癌症细胞经含HpD的MSN后的增殖和活力。采用创伤愈合测定技术(迁移试验)对癌症细胞侵袭性进行评价。采用DPPH(2,2-二苯基-1-苦基肼)法和FRAP(铁还原/抗氧化能力)法研究了HpD负载MSN的抗氧化作用。结果:癌症细胞系MCF7在含血卟啉(HpD)的二氧化硅纳米颗粒存在下的生存力和增殖能力显著下降(P=0.02),癌症细胞侵袭减少(P=0.025)。单独的二氧化硅纳米颗粒和负载血卟啉(HpD)对癌症细胞系显示出相当大的细胞毒性活性(IC50=20-30μg.mL-1)。发现用该化合物处理后MCF7细胞的增殖速率以剂量依赖性方式降低。DPPH法和FRAP法检测结果表明,含HpD的MSN和MSN具有抗氧化活性。结论:含HpD的MSN对MCF7细胞株的生长有抑制作用。MSN单独或与HpD组合对MCF7细胞系中的细胞侵袭具有抑制作用。MSN单独和负载HpD具有抗氧化作用。这些结果表明,MSN具有作为抗癌药物载体用于癌症治疗的潜力。关键词:二氧化硅纳米粒子;血卟啉;细胞活力;武装入侵抗氧化剂癌症乳腺癌;细胞系
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引用次数: 1
Virtual Reality: A Novel Approach in Rehabilitating People with Schizophrenia 虚拟现实:精神分裂症患者康复的一种新方法
Q4 Medicine Pub Date : 2018-06-23 DOI: 10.5812/MEJRH.80071
M. Z. Bidaki, S. B. Mousavi
: Since the introduction of schizophrenia, different approaches have been developed to ameliorate the symptoms or improve the quality of life in patients who are diagnosed with schizophrenia. Currently, scientists around the world are developing new techniques to treat and rehabilitate people with schizophrenia. One of these techniques is virtual reality, which benefits the patient through simulating the experience of acting in a variety of settings and interacting with virtual characters. In this study, we aimed to briefly introduce this technique to scholars in the field of psychiatry and rehabilitation.
自从引入精神分裂症以来,已经开发了不同的方法来改善被诊断患有精神分裂症的患者的症状或改善生活质量。目前,世界各地的科学家正在开发治疗和康复精神分裂症患者的新技术。其中一种技术是虚拟现实,它通过模拟在各种环境中表演和与虚拟人物互动的体验,使患者受益。在本研究中,我们旨在向精神病学和康复领域的学者简要介绍这种技术。
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引用次数: 2
Prediction Model for Self-Care Behaviors among Iranian Elders with Chronic Heart Failure 伊朗老年慢性心力衰竭患者自我护理行为的预测模型
Q4 Medicine Pub Date : 2018-06-21 DOI: 10.5812/MEJRH.69601
A. Kamrani, M. Foroughan, J. Charati, Z. Taraghi
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引用次数: 4
Sleep and Sleep Impairment in Victims of Traumatic Brain Injury 脑外伤患者的睡眠与睡眠障碍
Q4 Medicine Pub Date : 2018-04-21 DOI: 10.5812/MEJRH.65864
N. Gadoth
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引用次数: 0
Effect of Vitamin D on Hippocampus Brain-Derived Neurotrophic Factor Level in Chronic Mild Stress Model of Depression in Rats 维生素D对慢性轻度应激抑郁症大鼠海马脑源性神经营养因子水平的影响
Q4 Medicine Pub Date : 2018-04-21 DOI: 10.5812/MEJRH.63901
Z. Yousefian, A. Khaleghian, Homan Parsaei, Abbas Ali Vafaei, A. Rashidy-Pour, K. Sedaghat
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引用次数: 2
BMI1 as a Potential Target of miR-330-3p in Colorectal Cancer BMI1作为miR-330-3p在癌症大肠癌中的潜在靶点
Q4 Medicine Pub Date : 2018-04-21 DOI: 10.5812/MEJRH.66075
Mohammad Hasan Soheilifar, Abdolvahab Moshtaghian, R. Amini, Masoud Asefi, Parviz Basiri, M. Saidijam
Background: Colorectal cancer (CRC) is one of the most common cancers worldwide. CRC therapy is still a serious problem because of the presence of cancer stem cells (CSCs) within the tumor. BMI1 (B lymphoma Mo-MLV insertion region 1 homolog) is one of the important molecules for self-renewal of the CSCs and a component of poly comb repressive complex 1 that plays an important role in stimulating the progression of the cell cycle through epigenetic inhibition of tumor suppressors. BMI1 is a marker of colon stem cells that its expression increases in colorectal CSCs. The inhibition of BMI1 expression by miRNA could be one of the promising treatment options in CRC. Furthermore, investigating the regulation of BMI1 expression by miRNAs during tumorigenesis could be valuable in the identification of molecular mechanisms involved in CRC. Our aim was to conduct a bioinformatics analysis of known tumor suppressor miRNAs in CRC that have a potential to inhibit BMI1 expression. Methods: The presence of BMI-1, as a potential target of the selected miRNAs, was explored in various databases of miRNA target prediction including TargetScan, DIANA-microT, PicTar, miRanada, miRtar, mirMAP, and miRDB. These databases are based on algorithms such as miRNA-target interactions and thermodynamic stability (�G). miRNA with the highest score was selected according to the prediction score. Results: According to bioinformatics analysis, the highest score was derived for miR-330-3p. As a new miRNA to suppress BMI-1, miR-330-3p can be used in applied studies. Conclusions: Compared to other tumor suppressor miRNAs in CRC, miR-330-3p has the greatest probability to inhibit BMI1. Therefore, the experimental validation of miR-330-3p/BMI1 axis would be useful in identifying novel therapeutics and biomarkers in CRC. Keywords: Colorectal Cancer, miRNA, BMI1, Bioinformatics
背景:癌症是世界范围内最常见的癌症之一。由于肿瘤内存在癌症干细胞(CSCs),CRC治疗仍然是一个严重的问题。BMI1(B淋巴瘤Mo MLV插入区1同源物)是CSCs自我更新的重要分子之一,也是多梳抑制复合物1的一种成分,其通过肿瘤抑制剂的表观遗传学抑制在刺激细胞周期的进展中发挥重要作用。BMI1是结肠干细胞的标志物,其在结肠直肠癌干细胞中的表达增加。miRNA对BMI1表达的抑制可能是CRC中有前景的治疗选择之一。此外,研究miRNA在肿瘤发生过程中对BMI1表达的调节可能对鉴定CRC的分子机制有价值。我们的目的是对CRC中已知的具有抑制BMI1表达潜力的肿瘤抑制miRNA进行生物信息学分析。方法:在各种miRNA靶点预测数据库中,包括TargetScan、DIANA-microT、PicTar、miRanada、miRtar、mirMAP和miRDB,探索BMI-1作为所选miRNA的潜在靶点的存在。这些数据库基于miRNA靶标相互作用和热力学稳定性等算法(�G) 。根据预测得分选择得分最高的miRNA。结果:根据生物信息学分析,miR-330-3p得分最高。miR-330-3p作为一种新的抑制BMI-1的miRNA,可用于应用研究。结论:与CRC中的其他抑癌miRNA相比,miR-330-3p抑制BMI1的可能性最大。因此,miR-330-3p/BMI1轴的实验验证将有助于鉴定CRC的新疗法和生物标志物。关键词:结直肠癌癌症,miRNA,BMI1,生物信息学
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引用次数: 6
期刊
Middle East Journal of Rehabilitation and Health
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