Pub Date : 2022-09-19DOI: 10.1007/s40473-022-00252-1
H. Hadizadeh, J. M. Flores, Talia Mayerson, P. Worhunsky, M. Potenza, G. Angarita
{"title":"Glutamatergic Agents for the Treatment of Cocaine Use Disorder","authors":"H. Hadizadeh, J. M. Flores, Talia Mayerson, P. Worhunsky, M. Potenza, G. Angarita","doi":"10.1007/s40473-022-00252-1","DOIUrl":"https://doi.org/10.1007/s40473-022-00252-1","url":null,"abstract":"","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":"9 1","pages":"101 - 112"},"PeriodicalIF":1.7,"publicationDate":"2022-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41878046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-20DOI: 10.1007/s40473-022-00248-x
E. Leighton, M. Garrett, Amanda Beltrani, Jung-Yun Min, Victoria Schilder
{"title":"Capgras Syndrome and Other Delusions of Misidentification: a Summary of the Psychological, Psychiatric, and Neurophysiological Literature on DMI","authors":"E. Leighton, M. Garrett, Amanda Beltrani, Jung-Yun Min, Victoria Schilder","doi":"10.1007/s40473-022-00248-x","DOIUrl":"https://doi.org/10.1007/s40473-022-00248-x","url":null,"abstract":"","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":"9 1","pages":"93 - 99"},"PeriodicalIF":1.7,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47899141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-18DOI: 10.1007/s40473-022-00249-w
M. Garrett, E. Leighton
{"title":"Capgras Syndrome and Other Delusions of Misidentification: Integrating Neuropsychological Models of Delusion Formation with Psychoanalytic Object-Relations Theory","authors":"M. Garrett, E. Leighton","doi":"10.1007/s40473-022-00249-w","DOIUrl":"https://doi.org/10.1007/s40473-022-00249-w","url":null,"abstract":"","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":"9 1","pages":"84 - 92"},"PeriodicalIF":1.7,"publicationDate":"2022-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42651804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-17DOI: 10.1007/s40473-022-00247-y
Troy K. Chow, C. Bowie, Michel Morton, Aleksandra Lalovic, S. McInerney, S. Rizvi
{"title":"Contributors of Functional Impairment in Major Depressive Disorder: a Biopsychosocial Approach","authors":"Troy K. Chow, C. Bowie, Michel Morton, Aleksandra Lalovic, S. McInerney, S. Rizvi","doi":"10.1007/s40473-022-00247-y","DOIUrl":"https://doi.org/10.1007/s40473-022-00247-y","url":null,"abstract":"","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":"9 1","pages":"59 - 72"},"PeriodicalIF":1.7,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48025261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-01Epub Date: 2022-01-20DOI: 10.1007/s40473-021-00241-w
Stefanie F Gonçalves, Mary Ryan, Claire E Niehaus, Tara M Chaplin
Purpose of review: This review aims to summarize the research on brain activity during affective processing (i.e., reward, negative emotional stimuli, loss) and adolescent substance use (SU).
Recent findings: Most research revealed links between altered neural activity in midcingulo-insular, frontoparietal and other network regions and adolescent SU. Increased recruitment of midcingulo-insular regions-particularly the striatum-to positive affective stimuli (e.g., monetary reward) was most often associated with initiation and low-level use of substances, whereas decreased recruitment of these regions was most often associated with SUD and higher risk SU. In regards to negative affective stimuli, most research demonstrated increased recruitment of midcingulo-insular network regions. There is also evidence that these associations may be sex-specific.
Summary: Future research should employ longitudinal designs that assess affect-related brain activity prior to and following SU initiation and escalation. Moreover, examining sex as as moderating variable may help clarify if affective neural risk factors are sex-specific.
综述目的：本综述旨在总结情感处理（即奖赏、负面情绪刺激、失落）过程中的大脑活动与青少年药物使用（SU）的相关研究：大多数研究揭示了丘脑岛中部、额顶叶和其他网络区域神经活动的改变与青少年药物滥用之间的联系。中脑丘脑-岛叶区域（尤其是纹状体）对积极情绪刺激（如金钱奖励）的招募增加往往与药物的开始使用和低水平使用有关，而这些区域的招募减少往往与药物滥用和高风险药物滥用有关。关于负面情绪刺激，大多数研究表明，中脑-脑岛网络区域的招募增加。还有证据表明，这些关联可能具有性别特异性：小结：未来的研究应采用纵向设计，评估与情感相关的大脑活动在 SU 开始和升级之前和之后的情况。此外，将性别作为调节变量进行研究可能有助于澄清情感神经风险因素是否具有性别特异性。
{"title":"Affect-Related Brain Activity and Adolescent Substance Use: A Systematic Review.","authors":"Stefanie F Gonçalves, Mary Ryan, Claire E Niehaus, Tara M Chaplin","doi":"10.1007/s40473-021-00241-w","DOIUrl":"10.1007/s40473-021-00241-w","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review aims to summarize the research on brain activity during affective processing (i.e., reward, negative emotional stimuli, loss) and adolescent substance use (SU).</p><p><strong>Recent findings: </strong>Most research revealed links between altered neural activity in midcingulo-insular, frontoparietal and other network regions and adolescent SU. Increased recruitment of midcingulo-insular regions-particularly the striatum-to positive affective stimuli (e.g., monetary reward) was most often associated with initiation and low-level use of substances, whereas decreased recruitment of these regions was most often associated with SUD and higher risk SU. In regards to negative affective stimuli, most research demonstrated increased recruitment of midcingulo-insular network regions. There is also evidence that these associations may be sex-specific.</p><p><strong>Summary: </strong>Future research should employ longitudinal designs that assess affect-related brain activity prior to and following SU initiation and escalation. Moreover, examining sex as as moderating variable may help clarify if affective neural risk factors are sex-specific.</p>","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":"9 1","pages":"11-26"},"PeriodicalIF":1.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062006/pdf/nihms-1876463.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9287619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-28DOI: 10.1007/s40473-022-00246-z
H. Hadizadeh, J. Flores, E. Nunes, Talia Mayerson, M. Potenza, G. Angarita
{"title":"Novel Pharmacological Agents for the Treatment of Cocaine Use Disorder","authors":"H. Hadizadeh, J. Flores, E. Nunes, Talia Mayerson, M. Potenza, G. Angarita","doi":"10.1007/s40473-022-00246-z","DOIUrl":"https://doi.org/10.1007/s40473-022-00246-z","url":null,"abstract":"","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":"9 1","pages":"27 - 46"},"PeriodicalIF":1.7,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47061534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-13DOI: 10.1007/s40473-021-00245-6
Lorena A. Ferguson, Stephanie L. Leal
{"title":"Interactions of Emotion and Memory in the Aging Brain: Neural and Psychological Correlates","authors":"Lorena A. Ferguson, Stephanie L. Leal","doi":"10.1007/s40473-021-00245-6","DOIUrl":"https://doi.org/10.1007/s40473-021-00245-6","url":null,"abstract":"","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":"9 1","pages":"47-57"},"PeriodicalIF":1.7,"publicationDate":"2022-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46034229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-11DOI: 10.1007/s40473-021-00242-9
Fiza Arshad, L. Clark
{"title":"Immersion in Substance-Related and Behavioural Addictions: Neural Systems and Neurochemical Substrates","authors":"Fiza Arshad, L. Clark","doi":"10.1007/s40473-021-00242-9","DOIUrl":"https://doi.org/10.1007/s40473-021-00242-9","url":null,"abstract":"","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":"1 1","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2022-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46307207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01Epub Date: 2022-06-11DOI: 10.1007/s40473-021-00237-6
Janelle N Beadle, Angela Gifford, Abi Heller
Purpose of review: This narrative review highlights important factors contributing to loneliness in older adults prior to and during the COVID-19 pandemic and effects on brain health.
Recent findings: We characterize risk factors for loneliness in older adulthood and the impact of COVID-19. Furthermore, we discuss the implications of loneliness for older adults' brain health.
Summary: Understanding the multifactorial causes of loneliness in different subpopulations of older adults both before and during the COVID-19 pandemic will provide insights for the development of interventions targeted to reduce loneliness in older adults based on their specific risk factors.
{"title":"A Narrative Review of Loneliness and Brain Health in Older Adults: Implications of COVID-19.","authors":"Janelle N Beadle, Angela Gifford, Abi Heller","doi":"10.1007/s40473-021-00237-6","DOIUrl":"https://doi.org/10.1007/s40473-021-00237-6","url":null,"abstract":"<p><strong>Purpose of review: </strong>This narrative review highlights important factors contributing to loneliness in older adults prior to and during the COVID-19 pandemic and effects on brain health.</p><p><strong>Recent findings: </strong>We characterize risk factors for loneliness in older adulthood and the impact of COVID-19. Furthermore, we discuss the implications of loneliness for older adults' brain health.</p><p><strong>Summary: </strong>Understanding the multifactorial causes of loneliness in different subpopulations of older adults both before and during the COVID-19 pandemic will provide insights for the development of interventions targeted to reduce loneliness in older adults based on their specific risk factors.</p>","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":"9 3","pages":"73-83"},"PeriodicalIF":1.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40164742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01Epub Date: 2021-11-06DOI: 10.1007/s40473-021-00240-x
Crista E Maracic, Scott J Moeller
Purpose of review: Clinical insight is an emerging interest in substance use disorder research, but is difficult to study empirically. We reviewed recent research examining the behavioral and neural correlates of several psychological processes tapping into self-awareness that may in turn contribute to insight.
Recent findings: Individuals with substance use disorder exhibit deficits in self-monitoring (especially self-report / behavior dissociations), metacognition, alexithymia, readiness for behavior change, and interoception. Behavioral impairments have been further linked to neural abnormalities in a diverse network of brain regions encompassing cortical midline areas, insula, and frontal cortex, among others. Various treatment modalities may target these deficits, though corresponding effects on neural circuitry remain to be determined.
Summary: Compromised insight in substance use disorder may be relevant to a constellation of behaviors that suggest a lack of behavioral awareness linked to drug use. Future work needs to refine and advance the measurements, continuing to investigate insight problems in addiction that may become important therapeutic targets.
{"title":"Neural and Behavioral Correlates of Impaired Insight and Self-Awareness in Substance Use Disorder.","authors":"Crista E Maracic, Scott J Moeller","doi":"10.1007/s40473-021-00240-x","DOIUrl":"https://doi.org/10.1007/s40473-021-00240-x","url":null,"abstract":"<p><strong>Purpose of review: </strong>Clinical insight is an emerging interest in substance use disorder research, but is difficult to study empirically. We reviewed recent research examining the behavioral and neural correlates of several psychological processes tapping into self-awareness that may in turn contribute to insight.</p><p><strong>Recent findings: </strong>Individuals with substance use disorder exhibit deficits in self-monitoring (especially self-report / behavior dissociations), metacognition, alexithymia, readiness for behavior change, and interoception. Behavioral impairments have been further linked to neural abnormalities in a diverse network of brain regions encompassing cortical midline areas, insula, and frontal cortex, among others. Various treatment modalities may target these deficits, though corresponding effects on neural circuitry remain to be determined.</p><p><strong>Summary: </strong>Compromised insight in substance use disorder may be relevant to a constellation of behaviors that suggest a lack of behavioral awareness linked to drug use. Future work needs to refine and advance the measurements, continuing to investigate insight problems in addiction that may become important therapeutic targets.</p>","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":" ","pages":"113-123"},"PeriodicalIF":1.7,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9374000/pdf/nihms-1761037.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40615614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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