Current Behavioral Neuroscience Reports最新文献

Purpose of review: The objective of this article is to highlight the potential role of the galantamine-memantine combination as a novel antioxidant treatment for schizophrenia.

Recent findings: In addition to the well-known mechanisms of action of galantamine and memantine, these medications also have antioxidant activity. Furthermore, an interplay exists between oxidative stress, inflammation (redox-inflammatory hypothesis), and kynurenine pathway metabolites. Also, there is an interaction between brain-derived neurotrophic factor and oxidative stress in schizophrenia. Oxidative stress may be associated with positive, cognitive, and negative symptoms and impairments in white matter integrity in schizophrenia. The antipsychotic-galantamine-memantine combination may provide a novel strategy in schizophrenia to treat positive, cognitive, and negative symptoms.

Summary: A "single antioxidant" may be inadequate to counteract the complex cascade of oxidative stress. The galantamine-memantine combination as "double antioxidants" is promising. Hence, randomized controlled trials are warranted with the antipsychotic-galantamine-memantine combination with oxidative stress and antioxidant biomarkers in schizophrenia.

Purpose of the review: Negative symptoms are highly predictive of whether individuals at clinical high-risk (CHR) develop a psychotic disorder. However, little is known about pathophysiological mechanisms underlying negative symptoms during this period. The current study examined neurophysiological mechanisms underlying negative symptoms in CHR individuals using electroencephalography frontal alpha asymmetry power, a biomarker of approach and avoidance motivation.

Recent findings: People with schizophrenia display abnormal patterns of frontal alpha asymmetry indicative of reduced approach motivation. However, It is unknown whether similar abnormalities occur in CHR youth that predict negative symptoms.

Summary: Results indicated that CHR and healthy controls did not differ in frontal alpha asymmetry scores. However, in CHR youth, frontal alpha asymmetry was inversely correlated with the motivation and pleasure dimension of negative symptoms, which was accounted for by mood symptoms. Findings suggest that depression contributes to reduced approach motivation in CHR youth that manifests clinically as negative symptoms.

Purpose of review: This review provides an overview of the neurobiological mechanisms underlying opioid use disorder (OUD) drawing from genetic, functional and structural magnetic resonance imaging (MRI) research.

Recent findings: Preliminary evidence suggests an association between OUD and specific variants of the DRD2, δ-opioid receptor 1 (OPRD1) and μ-opioid receptor 1 (OPRM1) genes. Additionally, MRI research indicates functional and structural alterations in striatal and corticolimbic brain regions and pathways underlying reward, emotion/stress and cognitive control processes among individuals with OUD.

Summary: Individual differences in genetic and functional and structural brain-based features are correlated with differences in OUD severity and treatment outcomes, and therefore may potentially one day be used to inform OUD treatment selection. However, given the heterogeneous findings reported, further longitudinal research across different stages of opioid addiction is needed to yield a convergent characterization of OUD and improve treatment and prevention.

Purpose of review: While rates of other medical illnesses have declined over the past several decades, rates of suicide have increased, particularly among adolescents. Prior research on biological underpinnings of suicide risk has remained limited. In this review, we describe a recent model conceptualizing suicide as a failure of biological responses to acute stress. According to this model, youth who fail to mount an adaptive stress response following exposure to a stressor are at acute risk for suicide.

Recent findings: Although much more research is needed, early evidence suggests that abnormal biological responses to acute stress, such as altered autonomic nervous system activity and altered hypothalamic-pituitary-adrenal axis function, may underlie risk for suicide, particularly during the transition to adolescence.

Summary: Overall, initial evidence supports a link between biological responses to acute stress and suicide risk. However, future work that incorporates makers of other biological and environmental systems will sharpen our understanding of who is at suicide risk and when this risk is highest.