Pub Date : 2025-12-19DOI: 10.1186/s40795-025-01222-y
Stephanie B Jilcott Pitts, Qiang Wu, Melissa N Laska, Elizabeth Gates, Megumi H Seese, Katelyn E Senkus, Santiago Carrero Longlax, Alexandra Portillo-Varela, Andrew R DiNardo, Nancy E Moran
{"title":"Daily intake of a lycopene-rich juice is associated with reductions in inflammatory markers but not increases in skin carotenoids in a pilot study among participants with obesity.","authors":"Stephanie B Jilcott Pitts, Qiang Wu, Melissa N Laska, Elizabeth Gates, Megumi H Seese, Katelyn E Senkus, Santiago Carrero Longlax, Alexandra Portillo-Varela, Andrew R DiNardo, Nancy E Moran","doi":"10.1186/s40795-025-01222-y","DOIUrl":"10.1186/s40795-025-01222-y","url":null,"abstract":"","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":" ","pages":"11"},"PeriodicalIF":2.2,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12838468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The fortification of wheat flour with micronutrients is regarded as an effective strategy for preventing micronutrient deficits in the general population. Therefore, this study was intended to evaluate the storage stability of iron, zinc, and folic acid in fortified wheat flour, as well as the overall quality properties of flour during storage. Wheat flour was fortified (with zinc oxide 80 mg/kg, iron sodium EDTA 30 mg/kg, and 2 mg/kg folic acid) and stored over a 6-month period in a polyethylene bag. Iron was analyzed based on the AOAC official method 944.02, dry ash technique, ultraviolet-visible reading spectrophotometer. Zinc was determined using micro plasma atomic emission spectroscopy and the folic acid content was determined using HPLC. Micronutrients remain stable during storage. Zinc and iron showed no significant losses at stored temperatures. The percentages of zinc and iron retention ranged from 96.1 to 100%; however, folic acid showed significant losses, and the percentages of retention ranged from 68.5 to 87.8%. Peroxide value was increased from 0 to 0.1484milliequivalents per kilogram (mEq/kg) of fat during storage, and pH decreased from 6.23 to 5.38 during the period of six months of storage. The moisture content did not exhibit any significant changes. In conclusion, fortification of iron, zinc, and folic acid in wheat flour remains stable during storage for six months. Fortification is a good technique to lower population micronutrient deficits.
{"title":"Evaluation of the iron, zinc, and folic acid stability in fortified wheat flour storage and its impact on quality indicators.","authors":"Abebe Bitew Zegeye, Abebe Ayelign, Alebachew Habte Gezmu, Chere Tadesse, Kelemua Tesfaye, Misganaw Andualem, Zeweter Abebe Sime","doi":"10.1186/s40795-025-01213-z","DOIUrl":"10.1186/s40795-025-01213-z","url":null,"abstract":"<p><p>The fortification of wheat flour with micronutrients is regarded as an effective strategy for preventing micronutrient deficits in the general population. Therefore, this study was intended to evaluate the storage stability of iron, zinc, and folic acid in fortified wheat flour, as well as the overall quality properties of flour during storage. Wheat flour was fortified (with zinc oxide 80 mg/kg, iron sodium EDTA 30 mg/kg, and 2 mg/kg folic acid) and stored over a 6-month period in a polyethylene bag. Iron was analyzed based on the AOAC official method 944.02, dry ash technique, ultraviolet-visible reading spectrophotometer. Zinc was determined using micro plasma atomic emission spectroscopy and the folic acid content was determined using HPLC. Micronutrients remain stable during storage. Zinc and iron showed no significant losses at stored temperatures. The percentages of zinc and iron retention ranged from 96.1 to 100%; however, folic acid showed significant losses, and the percentages of retention ranged from 68.5 to 87.8%. Peroxide value was increased from 0 to 0.1484milliequivalents per kilogram (mEq/kg) of fat during storage, and pH decreased from 6.23 to 5.38 during the period of six months of storage. The moisture content did not exhibit any significant changes. In conclusion, fortification of iron, zinc, and folic acid in wheat flour remains stable during storage for six months. Fortification is a good technique to lower population micronutrient deficits.</p>","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":" ","pages":"226"},"PeriodicalIF":2.2,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12751853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145782799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1186/s40795-025-01220-0
Jie Deng, Xiaoming Liu, Haining Liu, Wei Lu
{"title":"Relationship and predictive value of controlling nutritional status score and serum vitamin level with coronary heart disease in young and middle-aged adults.","authors":"Jie Deng, Xiaoming Liu, Haining Liu, Wei Lu","doi":"10.1186/s40795-025-01220-0","DOIUrl":"10.1186/s40795-025-01220-0","url":null,"abstract":"","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":" ","pages":"227"},"PeriodicalIF":2.2,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12752140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145782760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-13DOI: 10.1186/s40795-025-01219-7
Min Xu, Runzhu Wang, Hong Zhao, Jiadan Fu, Xia Yu, Huafen Wang
{"title":"The impact of nutritional risk on the progression of COVID-19: a retrospective study.","authors":"Min Xu, Runzhu Wang, Hong Zhao, Jiadan Fu, Xia Yu, Huafen Wang","doi":"10.1186/s40795-025-01219-7","DOIUrl":"https://doi.org/10.1186/s40795-025-01219-7","url":null,"abstract":"","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145744416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence of stunting, wasting, and underweight among children aged 6 to 59 months and adolescents in pastoral and semi-pastoral areas of Ethiopia: a systematic review and meta-analysis.","authors":"Zekarias Markos, Yegle Asrat Tekletsadik, Ayenew Kassegn, Esubalew Muluneh Aligaz","doi":"10.1186/s40795-025-01210-2","DOIUrl":"10.1186/s40795-025-01210-2","url":null,"abstract":"","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":"11 1","pages":"221"},"PeriodicalIF":2.2,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12699853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145744313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-10DOI: 10.1186/s40795-025-01192-1
Anne Lene Løvhaug, Lisa Garnweidner-Holme, Laura Terragni, Arnfinn Helleve
Background: Cross-sector partnerships are governance models that are increasingly used in policy, research and practice to address food systems challenges including unhealthy diets. Despite ongoing debates about their value, especially in research, there is limited knowledge on the experiences of participating in these partnerships. This study is set in Norway, a country with tradition for cross-sector collaboration. We examine the Norwegian cross-sector research partnership NewTools to explore participants' perspectives in an early project stage. The partnership comprises 28 actors from research institutions, food industry, civil society and government agencies, and aims to develop two food profiling models: one for nutrition and one for environmental and social sustainability. This study can help identify initial factors that can influence nutrition-related cross-sector collaboration processes.
Methods: We conducted qualitative interviews with 17 NewTools-participants in 2022. Interviews were analyzed with reflexive thematic analysis.
Results: Five themes were identified: (i) "The importance of being in the room" illustrated participants views on the benefits of cross-sector collaboration, including sharing expertise and influencing project outcomes. (ii) "Divergent expectations towards collaboration and project aims" reflected varying expectations towards partner involvement and the project outcomes among participants. (iii) "Viewpoints towards food profiling systems" highlighted differing viewpoints on two food profiling models to be developed, with more skeptical views towards the nutrition profiling model. (iv) "Power asymmetries and mistrust" suggested potential tensions and some preexisting mistrust among partners. (v) "Pragmatic approach to COI and conflict management" conveyed that conflicts were considered manageable components of cross-sector collaboration.
Conclusions: In our study from an early project phase, participants described cross-sector collaboration as valuable and challenges as manageable. They also described potential tensions and mistrust between participants and diverging expectations towards roles and project objectives. These findings suggest that potential obstacles for collaboration were present in the project. This underscores the importance of investing time early in cross-sector research partnerships to clarify roles, align expectations and agree on project goals, which otherwise may turn into obstacles for collaboration between actors with varying mandates, interests, and expectations.
{"title":"Norwegian food system actors' perspectives on participating in a cross-sector research partnership: a qualitative study.","authors":"Anne Lene Løvhaug, Lisa Garnweidner-Holme, Laura Terragni, Arnfinn Helleve","doi":"10.1186/s40795-025-01192-1","DOIUrl":"10.1186/s40795-025-01192-1","url":null,"abstract":"<p><strong>Background: </strong>Cross-sector partnerships are governance models that are increasingly used in policy, research and practice to address food systems challenges including unhealthy diets. Despite ongoing debates about their value, especially in research, there is limited knowledge on the experiences of participating in these partnerships. This study is set in Norway, a country with tradition for cross-sector collaboration. We examine the Norwegian cross-sector research partnership NewTools to explore participants' perspectives in an early project stage. The partnership comprises 28 actors from research institutions, food industry, civil society and government agencies, and aims to develop two food profiling models: one for nutrition and one for environmental and social sustainability. This study can help identify initial factors that can influence nutrition-related cross-sector collaboration processes.</p><p><strong>Methods: </strong>We conducted qualitative interviews with 17 NewTools-participants in 2022. Interviews were analyzed with reflexive thematic analysis.</p><p><strong>Results: </strong>Five themes were identified: (i) \"The importance of being in the room\" illustrated participants views on the benefits of cross-sector collaboration, including sharing expertise and influencing project outcomes. (ii) \"Divergent expectations towards collaboration and project aims\" reflected varying expectations towards partner involvement and the project outcomes among participants. (iii) \"Viewpoints towards food profiling systems\" highlighted differing viewpoints on two food profiling models to be developed, with more skeptical views towards the nutrition profiling model. (iv) \"Power asymmetries and mistrust\" suggested potential tensions and some preexisting mistrust among partners. (v) \"Pragmatic approach to COI and conflict management\" conveyed that conflicts were considered manageable components of cross-sector collaboration.</p><p><strong>Conclusions: </strong>In our study from an early project phase, participants described cross-sector collaboration as valuable and challenges as manageable. They also described potential tensions and mistrust between participants and diverging expectations towards roles and project objectives. These findings suggest that potential obstacles for collaboration were present in the project. This underscores the importance of investing time early in cross-sector research partnerships to clarify roles, align expectations and agree on project goals, which otherwise may turn into obstacles for collaboration between actors with varying mandates, interests, and expectations.</p>","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":" ","pages":"4"},"PeriodicalIF":2.2,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12784486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145726485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-09DOI: 10.1186/s40795-025-01216-w
Yasamin Hozhabr Kalali, Ali Nikparast, Fatemeh S Hosseini, Seyed Ali Keshavarz, Hastimansooreh Ansar
{"title":"The association between dietary acid load and Kidney/Liver function in morbidly obese bariatric candidates.","authors":"Yasamin Hozhabr Kalali, Ali Nikparast, Fatemeh S Hosseini, Seyed Ali Keshavarz, Hastimansooreh Ansar","doi":"10.1186/s40795-025-01216-w","DOIUrl":"10.1186/s40795-025-01216-w","url":null,"abstract":"","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":" ","pages":"7"},"PeriodicalIF":2.2,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12801693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145716093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-04DOI: 10.1186/s40795-025-01217-9
Seyed Ali Abbas-Hashemi, Zahra Yari, Behzad Hatami, Amir Anushiravani, Shadi Kolahdoozan, Ali Zamanian, Nadia Akbarzadeh, Azita Hekmatdoost
{"title":"Effects of caffeine supplementation on lipid profile and handgrip strength in cirrhotic patients: a randomized, placebo- controlled, clinical trial.","authors":"Seyed Ali Abbas-Hashemi, Zahra Yari, Behzad Hatami, Amir Anushiravani, Shadi Kolahdoozan, Ali Zamanian, Nadia Akbarzadeh, Azita Hekmatdoost","doi":"10.1186/s40795-025-01217-9","DOIUrl":"10.1186/s40795-025-01217-9","url":null,"abstract":"","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":" ","pages":"6"},"PeriodicalIF":2.2,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12797547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145678881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-04DOI: 10.1186/s40795-025-01206-y
Roxana Michel Márquez-Herrera, Laura Cortés-Sanabria, Alfonso Martin Cueto-Manzano, Héctor Ramón Martínez-Ramírez, Enrique Rojas-Campos, Aaron González-Palacios, Claudia Nelly Orozco-González, Erika Fabiola Gómez-García
Background: Adequate clinical competence (CC) of dietitians for prevention and management of chronic kidney disease (CKD) could have enormous importance to reduce the burden of end- stage kidney disease (ESKD). Unfortunately, this issue has been poorly analyzed, particularly in primary health-care. Online education offers advantages; however, its effect on CC remains unclear. The aim of this study was to compare the effect of an online vs. face-to-face educative intervention on dietitians' clinical competence (CC) regarding nutritional care of early chronic kidney disease (CKD).
Methods: Dietitians were included in an online (N 51) or face-to-face group (N 23) to receive educational interventions developed by a multidisciplinary team, based on the constructivism paradigm and focused on nutritional aspects of prevention and management of early CKD. Content and duration (8 weeks) of both interventions were exactly the same. To evaluate CC, a validated questionnaire (120 points) was applied at the beginning and end of the study. Participation score (80 points) and satisfaction were evaluated.
Results: Age, gender, work experience, and previous training in end-stage kidney disease were similar and > 90% of participants completed the study in both groups. Comparing groups, participation scores were similar (p = 0.75): online 72.2 ± 4.6 points vs. face-to-face 74.1 ± 3.7 points. Baseline CC score was low in both groups: online 51 (41-65) points vs. face-to-face 49 (40-59) points, p = 0.60, but increased at the end of study: online group score increased 63% (26-91%, p < 0.0001) and face-to-face 74% (20-100%, p < 0.0001), without inter-group difference (p = 0.57).
{"title":"Online and face-to-face education are effective to improve clinical competence regarding nutritional care in early chronic kidney disease.","authors":"Roxana Michel Márquez-Herrera, Laura Cortés-Sanabria, Alfonso Martin Cueto-Manzano, Héctor Ramón Martínez-Ramírez, Enrique Rojas-Campos, Aaron González-Palacios, Claudia Nelly Orozco-González, Erika Fabiola Gómez-García","doi":"10.1186/s40795-025-01206-y","DOIUrl":"10.1186/s40795-025-01206-y","url":null,"abstract":"<p><strong>Background: </strong>Adequate clinical competence (CC) of dietitians for prevention and management of chronic kidney disease (CKD) could have enormous importance to reduce the burden of end- stage kidney disease (ESKD). Unfortunately, this issue has been poorly analyzed, particularly in primary health-care. Online education offers advantages; however, its effect on CC remains unclear. The aim of this study was to compare the effect of an online vs. face-to-face educative intervention on dietitians' clinical competence (CC) regarding nutritional care of early chronic kidney disease (CKD).</p><p><strong>Methods: </strong>Dietitians were included in an online (N 51) or face-to-face group (N 23) to receive educational interventions developed by a multidisciplinary team, based on the constructivism paradigm and focused on nutritional aspects of prevention and management of early CKD. Content and duration (8 weeks) of both interventions were exactly the same. To evaluate CC, a validated questionnaire (120 points) was applied at the beginning and end of the study. Participation score (80 points) and satisfaction were evaluated.</p><p><strong>Results: </strong>Age, gender, work experience, and previous training in end-stage kidney disease were similar and > 90% of participants completed the study in both groups. Comparing groups, participation scores were similar (p = 0.75): online 72.2 ± 4.6 points vs. face-to-face 74.1 ± 3.7 points. Baseline CC score was low in both groups: online 51 (41-65) points vs. face-to-face 49 (40-59) points, p = 0.60, but increased at the end of study: online group score increased 63% (26-91%, p < 0.0001) and face-to-face 74% (20-100%, p < 0.0001), without inter-group difference (p = 0.57).</p>","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":" ","pages":"3"},"PeriodicalIF":2.2,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12781519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145670274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-28DOI: 10.1186/s40795-025-01208-w
Alehegn Moges Tessema, Temesgen Zewotir, Richard Kabanda
<p><p>Malnutrition among children under five remains a critical public health challenge in Ethiopia and Rwanda, with nearly half of the children in this study population affected by at least one form of undernutrition. This study provides a robust causal analysis of the heterogeneous effects of Antenatal Care (ANC) on child malnutrition, as measured by the Composite Index of Anthropometric Failure (CIAF). Leveraging data from 33,737 mother-child pairs from the Demographic and Health Surveys (DHS) in Ethiopia (N = 22,668) and Rwanda (N = 11,069) across three waves (2005-2015), we employ a machine learning-based Causal Forest model. This approach was chosen specifically to overcome the limitations of traditional regression methods, allowing for the estimation of how the impact of different levels of ANC attendance varies across diverse sociodemographic and health-related subgroups. The results reveal a clear and powerful dose-response relationship. While a single ANC visit has a negligible effect, attending 2-3 visits is associated with a modest 3.5% point reduction in the risk of malnutrition. The strongest impact is seen with the completion of 4 or more visits, which is associated with an average reduction of 5.7% points (ATE: -0.057). Crucially, this average effect masks profound and policy-relevant heterogeneity. The benefits of ANC are massively amplified for the most vulnerable populations; for children in the poorer wealth quintile, 4 + ANC visits are associated with a massive 17.1% point reduction in malnutrition risk-an effect nearly three times the population average. The intervention is also particularly impactful for older mothers (aged 35-49), where it is associated with an 11.9% point risk reduction. Furthermore, the benefits of ANC are amplified by a healthier environment; for children in households with an improved water source, the associated risk reduction is a substantial 7.8% points, demonstrating a powerful synergistic effect between clinical care and public health infrastructure. The application of the Causal Forest model represents a significant advancement, moving beyond a single average effect to uncover this critical heterogeneity and identify for whom, and under what conditions, ANC is most effective. These findings provide robust causal evidence for a necessary shift away from a one-size-fits-all public health strategy. The results strongly advocate for stratified and multi-sectoral interventions. Policy and resources should be intensely focused on ensuring the most vulnerable populations-particularly the poorest households and older mothers-complete the full ANC schedule, as this is where the public health return on investment is highest. Additionally, the synergistic effect with WASH highlights the need to integrate clinical maternal health programs with investments in community-level water and sanitation infrastructure. By tailoring ANC programs and combining them with broader public health improvements, governments c
{"title":"Causal effects of Antenatal Care (ANC) on child malnutrition: a machine learning approach in Ethiopia and Rwanda.","authors":"Alehegn Moges Tessema, Temesgen Zewotir, Richard Kabanda","doi":"10.1186/s40795-025-01208-w","DOIUrl":"10.1186/s40795-025-01208-w","url":null,"abstract":"<p><p>Malnutrition among children under five remains a critical public health challenge in Ethiopia and Rwanda, with nearly half of the children in this study population affected by at least one form of undernutrition. This study provides a robust causal analysis of the heterogeneous effects of Antenatal Care (ANC) on child malnutrition, as measured by the Composite Index of Anthropometric Failure (CIAF). Leveraging data from 33,737 mother-child pairs from the Demographic and Health Surveys (DHS) in Ethiopia (N = 22,668) and Rwanda (N = 11,069) across three waves (2005-2015), we employ a machine learning-based Causal Forest model. This approach was chosen specifically to overcome the limitations of traditional regression methods, allowing for the estimation of how the impact of different levels of ANC attendance varies across diverse sociodemographic and health-related subgroups. The results reveal a clear and powerful dose-response relationship. While a single ANC visit has a negligible effect, attending 2-3 visits is associated with a modest 3.5% point reduction in the risk of malnutrition. The strongest impact is seen with the completion of 4 or more visits, which is associated with an average reduction of 5.7% points (ATE: -0.057). Crucially, this average effect masks profound and policy-relevant heterogeneity. The benefits of ANC are massively amplified for the most vulnerable populations; for children in the poorer wealth quintile, 4 + ANC visits are associated with a massive 17.1% point reduction in malnutrition risk-an effect nearly three times the population average. The intervention is also particularly impactful for older mothers (aged 35-49), where it is associated with an 11.9% point risk reduction. Furthermore, the benefits of ANC are amplified by a healthier environment; for children in households with an improved water source, the associated risk reduction is a substantial 7.8% points, demonstrating a powerful synergistic effect between clinical care and public health infrastructure. The application of the Causal Forest model represents a significant advancement, moving beyond a single average effect to uncover this critical heterogeneity and identify for whom, and under what conditions, ANC is most effective. These findings provide robust causal evidence for a necessary shift away from a one-size-fits-all public health strategy. The results strongly advocate for stratified and multi-sectoral interventions. Policy and resources should be intensely focused on ensuring the most vulnerable populations-particularly the poorest households and older mothers-complete the full ANC schedule, as this is where the public health return on investment is highest. Additionally, the synergistic effect with WASH highlights the need to integrate clinical maternal health programs with investments in community-level water and sanitation infrastructure. By tailoring ANC programs and combining them with broader public health improvements, governments c","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":" ","pages":"1"},"PeriodicalIF":2.2,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12771955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145639472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}