{"title":"Exosomal MicroRNAs as a Novel Diagnostic Biomarker for Rapid Detection of Mycobacterium tuberculosis and Nontuberculosis Mycobacteria","authors":"","doi":"10.4103/bbrj.bbrj_52_24","DOIUrl":"https://doi.org/10.4103/bbrj.bbrj_52_24","url":null,"abstract":"","PeriodicalId":36500,"journal":{"name":"Biomedical and Biotechnology Research Journal","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141717044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.4103/bbrj.bbrj_102_24
{"title":"Antibiotic Susceptibility and Genetic Diversity of Helicobacter pylori from a Tertiary Care Hospital in North India","authors":"","doi":"10.4103/bbrj.bbrj_102_24","DOIUrl":"https://doi.org/10.4103/bbrj.bbrj_102_24","url":null,"abstract":"","PeriodicalId":36500,"journal":{"name":"Biomedical and Biotechnology Research Journal","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141717084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.4103/bbrj.bbrj_103_24
{"title":"Morphological and Improvement of Human Adipose Stem Cells Derived Retinal Pigment Epithelium using Extracellular Matrix and Neural Retina Co-culture","authors":"","doi":"10.4103/bbrj.bbrj_103_24","DOIUrl":"https://doi.org/10.4103/bbrj.bbrj_103_24","url":null,"abstract":"","PeriodicalId":36500,"journal":{"name":"Biomedical and Biotechnology Research Journal","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141696773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigation Abutment Stress Shielding Distribution on Titanium Alloy Biomaterial under Bruxism Chewing Cycles: Three-dimensional Finite Element Chewing Simulation","authors":"","doi":"10.4103/bbrj.bbrj_63_24","DOIUrl":"https://doi.org/10.4103/bbrj.bbrj_63_24","url":null,"abstract":"","PeriodicalId":36500,"journal":{"name":"Biomedical and Biotechnology Research Journal","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141689197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.4103/bbrj.bbrj_135_24
{"title":"The Diagnostic Value of the Italian Score for Predicting Extended-spectrum β Lactamase-producing Enterobacterales Infection in Sepsis Patients at Dr. M. Djamil Central General Hospital Padang, Indonesia","authors":"","doi":"10.4103/bbrj.bbrj_135_24","DOIUrl":"https://doi.org/10.4103/bbrj.bbrj_135_24","url":null,"abstract":"","PeriodicalId":36500,"journal":{"name":"Biomedical and Biotechnology Research Journal","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141707379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.4103/bbrj.bbrj_163_24
{"title":"Investigating Intracellular Signaling Pathway and Telomerase Gene Expression in Nonsmall Cell Lung Cancer Treated with miR-302/367","authors":"","doi":"10.4103/bbrj.bbrj_163_24","DOIUrl":"https://doi.org/10.4103/bbrj.bbrj_163_24","url":null,"abstract":"","PeriodicalId":36500,"journal":{"name":"Biomedical and Biotechnology Research Journal","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141713085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.4103/bbrj.bbrj_100_24
{"title":"Be Prepared for Infectious Disease Crisis","authors":"","doi":"10.4103/bbrj.bbrj_100_24","DOIUrl":"https://doi.org/10.4103/bbrj.bbrj_100_24","url":null,"abstract":"","PeriodicalId":36500,"journal":{"name":"Biomedical and Biotechnology Research Journal","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141692508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unraveling the Complexities of Tuberculosis and Sarcoidosis: Insights into Diagnosis and Differentiation","authors":"","doi":"10.4103/bbrj.bbrj_81_24","DOIUrl":"https://doi.org/10.4103/bbrj.bbrj_81_24","url":null,"abstract":"","PeriodicalId":36500,"journal":{"name":"Biomedical and Biotechnology Research Journal","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141715358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.4103/bbrj.bbrj_154_24
{"title":"Unraveling the Etiological Profile of Recurrent Miscarriages at a Genetic Unit in India","authors":"","doi":"10.4103/bbrj.bbrj_154_24","DOIUrl":"https://doi.org/10.4103/bbrj.bbrj_154_24","url":null,"abstract":"","PeriodicalId":36500,"journal":{"name":"Biomedical and Biotechnology Research Journal","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141708320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.4103/bbrj.bbrj_202_22
Deepali Bansode, Naman Jain, Omkar Tambekar, S. Bodhankar
Background: In this study, we have investigated the binding affinity, ADME, and toxicity analysis of various phytocompounds which are present in Ziziphus jujuba on different receptors related to cardioprotective activity by performing molecular docking studies. Determination of binding affinity of phytocompounds of Z. Jujuba with different receptors involved in the cardioprotective activity. AutoDock Vina, PyMol, Discovery Studio, AutoDock tools, ChemDraw, Swiss ADME, PROTOX-II. Methods: Molecular docking. Results: The binding results of the selected plant compounds and target proteins, namely 108a, 7Q29, 5JMY, 4DLI, 2YCW, and 1CX2, showed that the selected phytochemicals from Z. Jujuba had good binding affinity and good receptor binding mode selected target. However, among all plant compounds, Jujuboside-B has the lowest binding energy with angiotensin-converting enzyme (ACE) (binding energy – 11.2 Kcal/mol), ACE and neutral endopeptidase inhibitors (binding energy – 10.9 Kcal/mol). Neprilysin receptor (binding energy – 10.4 Kcal/mol), COX-2 receptor (binding energy – 10.9 Kcal/mol), Spinosyn with β-1 adrenergic receptor (binding energy – 9.3 Kcal/mol), 3-O-methylellagic acid-3'-rhamnoside has superior binding affinity (−9.4 Kcal/mol) to the P38 mitogen-activated protein kinase receptor compared to the standard synthetic compound nebivolol. Conclusions: The present work was an attempt to computationally identify phytocompounds from Z. Jujuba which can bind to the various targets of cardiovascular disease. The docking scores, analysis of the interactions of the compounds suggest that most of the compounds have the ability to bind to multiple targets involved in cardiovascular disease. Absorption, distribution, metabolism, excretion, and toxicity and toxicity prediction showed various phytocompounds such as rutin, jujuboside-A, B, epicatechin could be used as potential candidate against cardiovascular disease.
{"title":"A comparative molecular docking study of phytocompounds of Ziziphus jujuba lam. with multiple receptors for the cardioprotective activity","authors":"Deepali Bansode, Naman Jain, Omkar Tambekar, S. Bodhankar","doi":"10.4103/bbrj.bbrj_202_22","DOIUrl":"https://doi.org/10.4103/bbrj.bbrj_202_22","url":null,"abstract":"Background: In this study, we have investigated the binding affinity, ADME, and toxicity analysis of various phytocompounds which are present in Ziziphus jujuba on different receptors related to cardioprotective activity by performing molecular docking studies. Determination of binding affinity of phytocompounds of Z. Jujuba with different receptors involved in the cardioprotective activity. AutoDock Vina, PyMol, Discovery Studio, AutoDock tools, ChemDraw, Swiss ADME, PROTOX-II. Methods: Molecular docking. Results: The binding results of the selected plant compounds and target proteins, namely 108a, 7Q29, 5JMY, 4DLI, 2YCW, and 1CX2, showed that the selected phytochemicals from Z. Jujuba had good binding affinity and good receptor binding mode selected target. However, among all plant compounds, Jujuboside-B has the lowest binding energy with angiotensin-converting enzyme (ACE) (binding energy – 11.2 Kcal/mol), ACE and neutral endopeptidase inhibitors (binding energy – 10.9 Kcal/mol). Neprilysin receptor (binding energy – 10.4 Kcal/mol), COX-2 receptor (binding energy – 10.9 Kcal/mol), Spinosyn with β-1 adrenergic receptor (binding energy – 9.3 Kcal/mol), 3-O-methylellagic acid-3'-rhamnoside has superior binding affinity (−9.4 Kcal/mol) to the P38 mitogen-activated protein kinase receptor compared to the standard synthetic compound nebivolol. Conclusions: The present work was an attempt to computationally identify phytocompounds from Z. Jujuba which can bind to the various targets of cardiovascular disease. The docking scores, analysis of the interactions of the compounds suggest that most of the compounds have the ability to bind to multiple targets involved in cardiovascular disease. Absorption, distribution, metabolism, excretion, and toxicity and toxicity prediction showed various phytocompounds such as rutin, jujuboside-A, B, epicatechin could be used as potential candidate against cardiovascular disease.","PeriodicalId":36500,"journal":{"name":"Biomedical and Biotechnology Research Journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47074571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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