Pub Date : 2023-04-27DOI: 10.26442/20795696.2023.1.201802
S. V. Shramko, V. Zorina, A. Vlasenko, M. A. Sabantsev
Aim. To determine the clinical, anamnestic, and immunological predictors of adenomyosis by developing a prognostic model of uterine fibroids with concomitant adenomyosis. Materials and methods. A retrospective single-center study was conducted at Kurbatov Novokuznetsk City Clinical Hospital №1, from 2012 to 2019. The model included 284 women with histologically confirmed uterine fibroids, of which 34.9% (99/284) were fibroids with adenomyosis and 65.1% (185/284) were isolated uterine fibroids. Logistic regression was used to develop the mathematical model. Results. Predictors of adenomyosis in patients with uterine fibroids have been established: age 43 years and older, concomitant endometrial hyperplasia, chronic inflammatory diseases of the cervix, menometrorrhagia, history of childbirth, history of endometrial disorders, varicose veins of the lower extremities, history of appendectomy, blood serum lactoferrin of more than 1.8 mg/L, interleukin-6 levels more than 2.8 pg/mL. The model has an accuracy of 91%, a sensitivity of 90%, a specificity of 92%, a positive predictive value of 85%, and a negative predictive value of 94%. Conclusion. The established predictors of adenomyosis allow for predicting the risk of adenomyosis in patients with uterine fibroids, facilitating effective treatment choices.
{"title":"Prediction of adenomyosis in patients with uterine fibroids","authors":"S. V. Shramko, V. Zorina, A. Vlasenko, M. A. Sabantsev","doi":"10.26442/20795696.2023.1.201802","DOIUrl":"https://doi.org/10.26442/20795696.2023.1.201802","url":null,"abstract":"Aim. To determine the clinical, anamnestic, and immunological predictors of adenomyosis by developing a prognostic model of uterine fibroids with concomitant adenomyosis. \u0000Materials and methods. A retrospective single-center study was conducted at Kurbatov Novokuznetsk City Clinical Hospital №1, from 2012 to 2019. The model included 284 women with histologically confirmed uterine fibroids, of which 34.9% (99/284) were fibroids with adenomyosis and 65.1% (185/284) were isolated uterine fibroids. Logistic regression was used to develop the mathematical model. \u0000Results. Predictors of adenomyosis in patients with uterine fibroids have been established: age 43 years and older, concomitant endometrial hyperplasia, chronic inflammatory diseases of the cervix, menometrorrhagia, history of childbirth, history of endometrial disorders, varicose veins of the lower extremities, history of appendectomy, blood serum lactoferrin of more than 1.8 mg/L, interleukin-6 levels more than 2.8 pg/mL. The model has an accuracy of 91%, a sensitivity of 90%, a specificity of 92%, a positive predictive value of 85%, and a negative predictive value of 94%. \u0000Conclusion. The established predictors of adenomyosis allow for predicting the risk of adenomyosis in patients with uterine fibroids, facilitating effective treatment choices.","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78533152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.26442/20795696.2023.1.201899
Nataliya M. Podzolkova, Vasilii В. Osadchev, O. Glazkova, K. Babkov, Yulia V. Denisova
The sexual activity of patients before and after the treatment of pelvic organ prolapse (POP) largely determines their quality of life and satisfaction with the intervention. This review analyzes current data on the nature of changes in sexual function in various pelvic organ prolapse correction methods. Particular attention is paid to a comparative assessment of the effect of available surgical techniques with abdominal and vaginal access on the risk of de novo dyspareunia. Based on the results of clinical studies and systematic reviews, the most optimal ways of correcting POP have been established; tools for assessing their effectiveness in routine clinical practice have been proposed; the importance of an interdisciplinary approach to the treatment of POP with the involvement of medical psychologists has been noted due to the significant role of emotional and behavioral factors in sexual dysfunction.
{"title":"The effect of pelvic organ prolapse and various options for its correction on female sexual function: A review","authors":"Nataliya M. Podzolkova, Vasilii В. Osadchev, O. Glazkova, K. Babkov, Yulia V. Denisova","doi":"10.26442/20795696.2023.1.201899","DOIUrl":"https://doi.org/10.26442/20795696.2023.1.201899","url":null,"abstract":"The sexual activity of patients before and after the treatment of pelvic organ prolapse (POP) largely determines their quality of life and satisfaction with the intervention. This review analyzes current data on the nature of changes in sexual function in various pelvic organ prolapse correction methods. Particular attention is paid to a comparative assessment of the effect of available surgical techniques with abdominal and vaginal access on the risk of de novo dyspareunia. Based on the results of clinical studies and systematic reviews, the most optimal ways of correcting POP have been established; tools for assessing their effectiveness in routine clinical practice have been proposed; the importance of an interdisciplinary approach to the treatment of POP with the involvement of medical psychologists has been noted due to the significant role of emotional and behavioral factors in sexual dysfunction.","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81761700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.26442/20795696.2023.1.202084
O. Pustotina, A. A. Gashenko, E. Ustinova, E. A. Lishova, A. Lopatina, Zhanna S. Techiieva, Z. Vizintin
Background. Embryo implantation failure remains an urgent issue of assisted reproductive technologies (ART). Aim. To determine the effect of intrauterine irradiation with a non-ablative erbium laser on the endometrium state using the histological and immunohistochemical examination and to evaluate its effectiveness in ART cryo-protocols. Materials and methods. The study enrolled 25 women aged 2645 with 1 to 5 failed implantations who were planning a pregnancy in a cryopreserved embryo transfer protocol. On days 610 of the menstrual cycle, all patients underwent a single procedure of intrauterine irradiation of the endometrium and cervical canal mucosa with an erbium laser in a non-ablative mode using Fotona SP Dynamis laser system (Slovenia). The histological and immunohistochemical data of the endometrium before and 12 months after the procedure and the pregnancy rate with subsequent transfer of the cryopreserved embryo were assessed. Results. Intrauterine irradiation with a non-ablative erbium laser increased the proliferative activity of the endometrium (p=0.029), the expression of vascular endothelial growth factor (p=0.029), reduced the sclerosis lesions in the spiral arteries and endometrial stroma, increased the expression of progesterone and estrogen receptors, thus significantly increasing the effectiveness of the ART cryo-protocols (p=0.013).
{"title":"A pilot study of the intrauterine non-ablative erbium laser effectiveness in the endometrium preparation for cryopreserved embryo transfer in women with a history of implantation failures","authors":"O. Pustotina, A. A. Gashenko, E. Ustinova, E. A. Lishova, A. Lopatina, Zhanna S. Techiieva, Z. Vizintin","doi":"10.26442/20795696.2023.1.202084","DOIUrl":"https://doi.org/10.26442/20795696.2023.1.202084","url":null,"abstract":"Background. Embryo implantation failure remains an urgent issue of assisted reproductive technologies (ART). \u0000Aim. To determine the effect of intrauterine irradiation with a non-ablative erbium laser on the endometrium state using the histological and immunohistochemical examination and to evaluate its effectiveness in ART cryo-protocols. \u0000Materials and methods. The study enrolled 25 women aged 2645 with 1 to 5 failed implantations who were planning a pregnancy in a cryopreserved embryo transfer protocol. On days 610 of the menstrual cycle, all patients underwent a single procedure of intrauterine irradiation of the endometrium and cervical canal mucosa with an erbium laser in a non-ablative mode using Fotona SP Dynamis laser system (Slovenia). The histological and immunohistochemical data of the endometrium before and 12 months after the procedure and the pregnancy rate with subsequent transfer of the cryopreserved embryo were assessed. \u0000Results. Intrauterine irradiation with a non-ablative erbium laser increased the proliferative activity of the endometrium (p=0.029), the expression of vascular endothelial growth factor (p=0.029), reduced the sclerosis lesions in the spiral arteries and endometrial stroma, increased the expression of progesterone and estrogen receptors, thus significantly increasing the effectiveness of the ART cryo-protocols (p=0.013).","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75569392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.26442/20795696.2023.1.202098
S. P. Sinchikhin, I. A. Salov, E. Proskurina, Ekaterina S. Sinchikhina
Background. Asymptomatic bacteriuria in pregnant women can contribute to urological and gestational complications. Antibiotic therapy is recommended in patients with 105 CFU/mL and above in the urine. However, choosing antimicrobial therapy is challenging for those with 103104 CFU/mL. Aim. To assess the effectiveness of Superlymph combined with phytotherapy in pregnant women with asymptomatic bacteriuria. Materials and methods. Pregnant women aged 21 to 38 with asymptomatic bacteriuria (bacterial count of 103104 CFU/mL), comparable in age, reproductive history, and extragenital comorbidities, were divided into three groups. In group 1 (32 subjects), Superlymph and a herbal medicine containing centaury, lovage root, and rosemary leaves were used. In group 2 (33 subjects), only the herbal medicinal product was used. In group 3 (35 subjects), the above drug products were not used. The patients received the herbal medicinal product containing centaury, lovage root, and rosemary leaves 2 tablets TID for 14 days. Superlymph was administered intravaginally (1 suppository [10 units] BID for 10 days). A follow-up urine culture for groups 1 and 2 was taken 23 weeks after the completion of therapy, and for patients of group 3, 23 weeks after the previous culture. A routine general clinical assessment of pregnant women was performed. Statistical analysis was carried out using the Statistica 12.0 software. Results. Patients of the main group that received the peptide-cytokine and herbal medicinal products had the most significant improvement compared with pregnant women of other groups, as shown by complete eradication from the urinary tract of Escherichia coli, improved urinary laboratory tests, cytology, and fewer gestational complications. Premature onset of labor was significantly less common (6-fold) in patients of the main group versus controls, who refused the proposed therapy for asymptomatic (moderate) bacteriuria. Conclusion. The addition of peptide-cytokine agent Superlymph increases the treatment effectiveness in pregnant women with asymptomatic bacteriuria.
{"title":"Evaluation of the effectiveness of an antimicrobial peptide-cytokine product in the complex treatment of pregnant women with asymptomatic bacteriuria","authors":"S. P. Sinchikhin, I. A. Salov, E. Proskurina, Ekaterina S. Sinchikhina","doi":"10.26442/20795696.2023.1.202098","DOIUrl":"https://doi.org/10.26442/20795696.2023.1.202098","url":null,"abstract":"Background. Asymptomatic bacteriuria in pregnant women can contribute to urological and gestational complications. Antibiotic therapy is recommended in patients with 105 CFU/mL and above in the urine. However, choosing antimicrobial therapy is challenging for those with 103104 CFU/mL. \u0000Aim. To assess the effectiveness of Superlymph combined with phytotherapy in pregnant women with asymptomatic bacteriuria. \u0000Materials and methods. Pregnant women aged 21 to 38 with asymptomatic bacteriuria (bacterial count of 103104 CFU/mL), comparable in age, reproductive history, and extragenital comorbidities, were divided into three groups. In group 1 (32 subjects), Superlymph and a herbal medicine containing centaury, lovage root, and rosemary leaves were used. In group 2 (33 subjects), only the herbal medicinal product was used. In group 3 (35 subjects), the above drug products were not used. The patients received the herbal medicinal product containing centaury, lovage root, and rosemary leaves 2 tablets TID for 14 days. Superlymph was administered intravaginally (1 suppository [10 units] BID for 10 days). A follow-up urine culture for groups 1 and 2 was taken 23 weeks after the completion of therapy, and for patients of group 3, 23 weeks after the previous culture. A routine general clinical assessment of pregnant women was performed. Statistical analysis was carried out using the Statistica 12.0 software. \u0000Results. Patients of the main group that received the peptide-cytokine and herbal medicinal products had the most significant improvement compared with pregnant women of other groups, as shown by complete eradication from the urinary tract of Escherichia coli, improved urinary laboratory tests, cytology, and fewer gestational complications. Premature onset of labor was significantly less common (6-fold) in patients of the main group versus controls, who refused the proposed therapy for asymptomatic (moderate) bacteriuria. \u0000Conclusion. The addition of peptide-cytokine agent Superlymph increases the treatment effectiveness in pregnant women with asymptomatic bacteriuria.","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74515444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.26442/20795696.2023.1.202069
Y. Dobrohotova, V. Taranov, I. Lapina, A. Tyan, T. G. Chirvon, Nikita V. Glebov, Olesya V. Kaykova, Anastasiya A. Malakhova
Pelvic organ prolapse refers to a group of multidisciplinary disorders with various etiological components involved in its pathogenesis, destabilizing the ligamentous and musculofascial apparatus. In most cases, pelvic floor dysfunction requires surgical treatment, eliminating existing defects and clinical symptoms and improving patients' quality of life. Corrective surgery for genital prolapse by laparoscopic approach is highly effective and is associated with a low risk of adverse clinical outcomes. However, despite the significant progress and improvement of surgical treatment options, choosing the optimal treatment method based on a personalized approach remains an urgent issue. This literature review reviews traditional and alternative methods of laparoscopic correction of pelvic organ prolapse.
{"title":"Laparoscopic correction of pelvic organ prolapse and stress urinary incontinence: a current view of the problem","authors":"Y. Dobrohotova, V. Taranov, I. Lapina, A. Tyan, T. G. Chirvon, Nikita V. Glebov, Olesya V. Kaykova, Anastasiya A. Malakhova","doi":"10.26442/20795696.2023.1.202069","DOIUrl":"https://doi.org/10.26442/20795696.2023.1.202069","url":null,"abstract":"Pelvic organ prolapse refers to a group of multidisciplinary disorders with various etiological components involved in its pathogenesis, destabilizing the ligamentous and musculofascial apparatus. In most cases, pelvic floor dysfunction requires surgical treatment, eliminating existing defects and clinical symptoms and improving patients' quality of life. Corrective surgery for genital prolapse by laparoscopic approach is highly effective and is associated with a low risk of adverse clinical outcomes. However, despite the significant progress and improvement of surgical treatment options, choosing the optimal treatment method based on a personalized approach remains an urgent issue. This literature review reviews traditional and alternative methods of laparoscopic correction of pelvic organ prolapse.","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"397 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84773848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.26442/20795696.2023.1.202066
E. Silantyeva, M. R. Orazov, M. Khamoshina, E. Astafeva
Dyspareunia is a condition associated with a wide range of disorders. Pelvic floor dysfunction, manifesting as a myofascial syndrome or pelvic floor muscle hypertonia, may predict dyspareunia in women in different age groups. The review addresses the current view on the dyspareunia pathogenesis associated with pelvic floor muscle dysfunction.
{"title":"Pathogenesis of dyspareunia associated with pelvic floor dysfunction: A review","authors":"E. Silantyeva, M. R. Orazov, M. Khamoshina, E. Astafeva","doi":"10.26442/20795696.2023.1.202066","DOIUrl":"https://doi.org/10.26442/20795696.2023.1.202066","url":null,"abstract":"Dyspareunia is a condition associated with a wide range of disorders. Pelvic floor dysfunction, manifesting as a myofascial syndrome or pelvic floor muscle hypertonia, may predict dyspareunia in women in different age groups. The review addresses the current view on the dyspareunia pathogenesis associated with pelvic floor muscle dysfunction.","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"502 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73618077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.26442/20795696.2023.1.202116
V. Tskhay, Pavel K. Yametov, Yuriy S. Raspopin, Natalia M. Yametova, G. N. Polstyanaya, Daniil A. Ryabinin
A few randomized multicenter studies indicate that prophylactic vasopressin in obstetric and gynecological surgeries is mainly safe and associated with a significant reduction in intraoperative blood loss. This article reviews recent scientific papers describing the use of vasopressin in obstetric and gynecological practice with an assessment of its effectiveness depending on the dose and route of administration. We present a clinical case demonstrating that drugs with a vasopressor effect, in particular terlipressin, in a patient with uterine bleeding after a late induced miscarriage allowed to obtain an excellent hemostatic effect and avoid the need for additional methods of surgical hemostasis.
{"title":"Terlipressin in obstetric and gynecological practice: a case of a missed miscarriage in late pregnancy complicated by bleeding. Case report","authors":"V. Tskhay, Pavel K. Yametov, Yuriy S. Raspopin, Natalia M. Yametova, G. N. Polstyanaya, Daniil A. Ryabinin","doi":"10.26442/20795696.2023.1.202116","DOIUrl":"https://doi.org/10.26442/20795696.2023.1.202116","url":null,"abstract":"A few randomized multicenter studies indicate that prophylactic vasopressin in obstetric and gynecological surgeries is mainly safe and associated with a significant reduction in intraoperative blood loss. This article reviews recent scientific papers describing the use of vasopressin in obstetric and gynecological practice with an assessment of its effectiveness depending on the dose and route of administration. We present a clinical case demonstrating that drugs with a vasopressor effect, in particular terlipressin, in a patient with uterine bleeding after a late induced miscarriage allowed to obtain an excellent hemostatic effect and avoid the need for additional methods of surgical hemostasis.","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"83 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78103750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.26442/20795696.2023.1.201803
T. Makarenko, Darya E. Galkina, E. A. Borisova
Endometriosis remains one of the most topical diseases in current gynecology and is a multifactorial condition with an overgrowth of tissue morphologically and functionally similar to the endometrium outside the uterine cavity. One of the most frequently diagnosed forms of endometriosis is endometrioid ovarian cysts. An important feature of the clinical course of ovarian endometriosis is its negative impact on reproductive function and the recurrent nature of the disease, which may require repeated surgeries with even greater damage to the ovarian tissue. Therefore, the development of a long-term drug treatment strategy for patients with a history of endometrioid cysts aimed at preventing recurrences is urgently needed. According to domestic and foreign clinical guidelines, progestagen hormone therapy is recommended as first-line therapy for such patients. One of the most clinically studied drugs with a favorable efficacy and safety profile proven in numerous studies is dienogest. The paper presents the experience of foreign and domestic authors in conservative therapy in patients with a history of endometrioid cysts using dienogest in terms of recurrence prophylaxis.
{"title":"Conservative treatment strategies for endometrioid ovarian cysts: A review","authors":"T. Makarenko, Darya E. Galkina, E. A. Borisova","doi":"10.26442/20795696.2023.1.201803","DOIUrl":"https://doi.org/10.26442/20795696.2023.1.201803","url":null,"abstract":"Endometriosis remains one of the most topical diseases in current gynecology and is a multifactorial condition with an overgrowth of tissue morphologically and functionally similar to the endometrium outside the uterine cavity. One of the most frequently diagnosed forms of endometriosis is endometrioid ovarian cysts. An important feature of the clinical course of ovarian endometriosis is its negative impact on reproductive function and the recurrent nature of the disease, which may require repeated surgeries with even greater damage to the ovarian tissue. Therefore, the development of a long-term drug treatment strategy for patients with a history of endometrioid cysts aimed at preventing recurrences is urgently needed. According to domestic and foreign clinical guidelines, progestagen hormone therapy is recommended as first-line therapy for such patients. One of the most clinically studied drugs with a favorable efficacy and safety profile proven in numerous studies is dienogest. The paper presents the experience of foreign and domestic authors in conservative therapy in patients with a history of endometrioid cysts using dienogest in terms of recurrence prophylaxis.","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"228 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89030945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.26442/20795696.2023.1.202137
N. Podzolkova, L. Sumyatina
Sexual dysfunction in women is a complex interdisciplinary medical problem that remains beyond the attention of an obstetrician-gynecologist and negatively affects a woman's quality of life and well-being. The article presents data on prospects for using herbal agents based on the chasteberry fruit extract (Vitex agnus-castus, chaste tree) in women with sexual dysfunction.
{"title":"Sexual dysfunction: an interdisciplinary problem of classical gynecology","authors":"N. Podzolkova, L. Sumyatina","doi":"10.26442/20795696.2023.1.202137","DOIUrl":"https://doi.org/10.26442/20795696.2023.1.202137","url":null,"abstract":"Sexual dysfunction in women is a complex interdisciplinary medical problem that remains beyond the attention of an obstetrician-gynecologist and negatively affects a woman's quality of life and well-being. The article presents data on prospects for using herbal agents based on the chasteberry fruit extract (Vitex agnus-castus, chaste tree) in women with sexual dysfunction.","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79441386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.26442/20795696.2023.1.202070
A. M. Ziganshin, Sergej V. Keidar, R. Khalitova, A. Mulyukov, Emiliya N. Muhamed'yarova
Human papillomavirus (HPV) is now considered the most common sexually transmitted infection. Since the discovery by Nobel laureate Harald zur Hausen (2008) of HPV as a virus with a high carcinogenic risk, the strategy for screening and prevention of this disease has changed dramatically. It has significantly increased the relevance of the study of this infection. Although HPV is not life-threatening, its highly oncogenic subtypes can lead to the development of cervical cancer with high mortality.
人乳头瘤病毒(HPV)现在被认为是最常见的性传播感染。自从诺贝尔奖得主Harald zur Hausen(2008)发现HPV是一种具有高致癌风险的病毒以来，筛查和预防这种疾病的策略发生了巨大变化。它大大增加了研究这种感染的相关性。虽然HPV不会危及生命，但其高致癌性亚型可导致宫颈癌的发展，死亡率很高。
{"title":"Human papillomavirus: etiology, pathogenesis, role, and importance in the development of cervical cancer: A review","authors":"A. M. Ziganshin, Sergej V. Keidar, R. Khalitova, A. Mulyukov, Emiliya N. Muhamed'yarova","doi":"10.26442/20795696.2023.1.202070","DOIUrl":"https://doi.org/10.26442/20795696.2023.1.202070","url":null,"abstract":"Human papillomavirus (HPV) is now considered the most common sexually transmitted infection. Since the discovery by Nobel laureate Harald zur Hausen (2008) of HPV as a virus with a high carcinogenic risk, the strategy for screening and prevention of this disease has changed dramatically. It has significantly increased the relevance of the study of this infection. Although HPV is not life-threatening, its highly oncogenic subtypes can lead to the development of cervical cancer with high mortality.","PeriodicalId":36505,"journal":{"name":"Gynecology","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73248825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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