Pub Date : 2023-03-19DOI: 10.16931/1995-5464.2023-1-25-32
O. Melekhina, A. B. Musatov, J. V. Kulezneva, M. Efanov, V. Tsvirkun, R. Alikhanov, E. O. Amkhadov, B. A. Sadykov, D. Kantimerov, K. K. Salnikov
Aim. To evaluate the effectiveness of percutaneous ALPPS as a method for preventing post-resection liver failure.Materials and methods. The methodology involved a retrospective study of the results of portovenous embolization and percutaneous radiofrequency assisted liver partition with portal vein embolization (PRALLPS), in case of the future liver volume <40% . The degree of hypertrophy of the future liver remnant and its rate were assessed in two groups. Complications of manipulation and frequency of postresection hepatic failure were studied.Results. In the first stage, portenous embolization was successfully performed in 38 patients and PRALLPS was successfully performed in 47 patients. In the second stage, liver resection was performed in 27 (71.1%) and 33 (70%) patients. The most frequent complication of PRALLPS was bile accumulation in the radiofrequency ablation area (13.1%). The incidence of other complications of the first stage did not differ between groups. No differences in blood loss or incidence of liver failure were reported after the second stage. No fatal outcomes reported. The mean degree of hypertrophy and growth did not differ between the groups. The mean time of hypertrophy of the future liver remnant after percutaneous radiofrequency assisted partition of the parenchyma with portal vein embolization and portenous embolization was 13 ± 5 and 18 ± 7 days (p = 0.008).Conclusion. The results of percutaneous radiofrequency assisted liver partition with portal vein embolization are comparable in terms of safety with those of portenous embolization. Radiofrequency partition of the parenchyma with portal vein embolization enables optimal hypertrophy of the future liver remnant to be achieved faster.
{"title":"Radiosurgical interventions in the prevention of post-resection liver failure","authors":"O. Melekhina, A. B. Musatov, J. V. Kulezneva, M. Efanov, V. Tsvirkun, R. Alikhanov, E. O. Amkhadov, B. A. Sadykov, D. Kantimerov, K. K. Salnikov","doi":"10.16931/1995-5464.2023-1-25-32","DOIUrl":"https://doi.org/10.16931/1995-5464.2023-1-25-32","url":null,"abstract":"Aim. To evaluate the effectiveness of percutaneous ALPPS as a method for preventing post-resection liver failure.Materials and methods. The methodology involved a retrospective study of the results of portovenous embolization and percutaneous radiofrequency assisted liver partition with portal vein embolization (PRALLPS), in case of the future liver volume <40% . The degree of hypertrophy of the future liver remnant and its rate were assessed in two groups. Complications of manipulation and frequency of postresection hepatic failure were studied.Results. In the first stage, portenous embolization was successfully performed in 38 patients and PRALLPS was successfully performed in 47 patients. In the second stage, liver resection was performed in 27 (71.1%) and 33 (70%) patients. The most frequent complication of PRALLPS was bile accumulation in the radiofrequency ablation area (13.1%). The incidence of other complications of the first stage did not differ between groups. No differences in blood loss or incidence of liver failure were reported after the second stage. No fatal outcomes reported. The mean degree of hypertrophy and growth did not differ between the groups. The mean time of hypertrophy of the future liver remnant after percutaneous radiofrequency assisted partition of the parenchyma with portal vein embolization and portenous embolization was 13 ± 5 and 18 ± 7 days (p = 0.008).Conclusion. The results of percutaneous radiofrequency assisted liver partition with portal vein embolization are comparable in terms of safety with those of portenous embolization. Radiofrequency partition of the parenchyma with portal vein embolization enables optimal hypertrophy of the future liver remnant to be achieved faster.","PeriodicalId":36549,"journal":{"name":"Annals of HPB Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48954780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-19DOI: 10.16931/1995-5464.2023-1-53-61
T. Dyuzheva, A. Pashkovskaya, M. V. Tokarev, A. P. Stepanchenko, A. E. Voynovskiy, I. A. Semenenko, A. Sokolov, S. A. Grashchenko, A. Klimova
{"title":"Perfusion CT in predicting deep pancreatic necrosis and planning early interventions for severe acute pancreatitis","authors":"T. Dyuzheva, A. Pashkovskaya, M. V. Tokarev, A. P. Stepanchenko, A. E. Voynovskiy, I. A. Semenenko, A. Sokolov, S. A. Grashchenko, A. Klimova","doi":"10.16931/1995-5464.2023-1-53-61","DOIUrl":"https://doi.org/10.16931/1995-5464.2023-1-53-61","url":null,"abstract":"","PeriodicalId":36549,"journal":{"name":"Annals of HPB Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45638202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-19DOI: 10.16931/1995-5464.2023-1-71-79
A. Kotelnikov, Y. Patyutko, D. Podluzhnyi, M. S. Saakyan, N. E. Kushlinski, N. Lubimova, Y. Timofeev, R. G. Shakhbazyan, A. N. Polyakov, N. E. Kudashki, P. A. Tikhonov, I. Stilidi
At present, pancreaticoduodenoctomy causes the high incidence of complications. However, it is associated with an acceptable level of postoperative mortality. With this regard and taking into consideration a significant increase in survival in pancreatic cancer, it is highly relevant to study the negative functional outcomes of surgery and develop methods for their surgical prevention. The bibliographic review focuses on the features of three main postsurgical syndromes: gastric stasis, pancreatic exocrine and endocrine insufficiency. The study shows the dependence of these syndromes on pathomorphological characteristics of pancreatic stump, preservation of the pyloric, the variant of pancreatodigestive anastomosis and other features of reconstructive stage of the surgery.
{"title":"Functional outcomes of pancreaticoduodenoctomy","authors":"A. Kotelnikov, Y. Patyutko, D. Podluzhnyi, M. S. Saakyan, N. E. Kushlinski, N. Lubimova, Y. Timofeev, R. G. Shakhbazyan, A. N. Polyakov, N. E. Kudashki, P. A. Tikhonov, I. Stilidi","doi":"10.16931/1995-5464.2023-1-71-79","DOIUrl":"https://doi.org/10.16931/1995-5464.2023-1-71-79","url":null,"abstract":"At present, pancreaticoduodenoctomy causes the high incidence of complications. However, it is associated with an acceptable level of postoperative mortality. With this regard and taking into consideration a significant increase in survival in pancreatic cancer, it is highly relevant to study the negative functional outcomes of surgery and develop methods for their surgical prevention. The bibliographic review focuses on the features of three main postsurgical syndromes: gastric stasis, pancreatic exocrine and endocrine insufficiency. The study shows the dependence of these syndromes on pathomorphological characteristics of pancreatic stump, preservation of the pyloric, the variant of pancreatodigestive anastomosis and other features of reconstructive stage of the surgery.","PeriodicalId":36549,"journal":{"name":"Annals of HPB Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43418675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-19DOI: 10.16931/1995-5464.2023-1-33-40
V. V. Borovik, I. I. Tileubergenov, I. Rutkin, D. Maystrenko, D. Granov
{"title":"Results of liver retransplantations","authors":"V. V. Borovik, I. I. Tileubergenov, I. Rutkin, D. Maystrenko, D. Granov","doi":"10.16931/1995-5464.2023-1-33-40","DOIUrl":"https://doi.org/10.16931/1995-5464.2023-1-33-40","url":null,"abstract":"","PeriodicalId":36549,"journal":{"name":"Annals of HPB Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41951521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-19DOI: 10.16931/1995-5464.2023-1-88-96
S. Remizov, A. Andreev, V. M. Durleshter, S. A. Gabriel’, Y. S. Kuznetsov, O. V. Zasyadko
{"title":"Modern methods of minimally invasive surgery for patients with acute pancreatitis","authors":"S. Remizov, A. Andreev, V. M. Durleshter, S. A. Gabriel’, Y. S. Kuznetsov, O. V. Zasyadko","doi":"10.16931/1995-5464.2023-1-88-96","DOIUrl":"https://doi.org/10.16931/1995-5464.2023-1-88-96","url":null,"abstract":"","PeriodicalId":36549,"journal":{"name":"Annals of HPB Surgery","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41502967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-19DOI: 10.16931/1995-5464.2023-1-109-115
S. Budzinskiy, S. Shapovalyants, E. A. Vorobyova, P. Kozlova, N. S. Solovjev, E. Platonova, E. D. Fedorov
{"title":"Successful endoscopic treatment of giant multiple choledocholithiasis using oral transpapillary cholangioscopy and intraductal contact lithotripsy","authors":"S. Budzinskiy, S. Shapovalyants, E. A. Vorobyova, P. Kozlova, N. S. Solovjev, E. Platonova, E. D. Fedorov","doi":"10.16931/1995-5464.2023-1-109-115","DOIUrl":"https://doi.org/10.16931/1995-5464.2023-1-109-115","url":null,"abstract":"","PeriodicalId":36549,"journal":{"name":"Annals of HPB Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44044930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-19DOI: 10.16931/1995-5464.2023-1-10-24
S. Voskanyan, I. Kolyshev, A. Bashkov, A. Artemiev, V. Rudakov, M. Shabalin, A. Maltseva, M. Popov, A. Sushkov, G. V. Vohmyanin
Aim. To describe new data and to complement the existing information about the anatomic features of the hepatic vein structure in the donor of the right hepatic lobe, to formulate the principles of donor selection proceeding from vascular anatomy.Materials and methods. 306 liver transplantations from living related donors were performed at A.I. Burnazyan Federal Medical Biophysical Center of Federal Medical and Biological Agency of Russia from 2009 to 2021. The vascular anatomy of 518 potential donors was analyzed. The prevalence of different vein structures of the right hepatic lobe was assessed.Results. The authors identified 14 subtypes of anatomy of efferent vessels. They were classified into 3 types depending on the contribution of the median vein to the blood outflow from the right hepatic lobe: caval (67.3%), cava medial (semi-separate, 29%), and separate (3.6%).Conclusion. The anatomy of the efferent vessels of the right lobe graft is characterized by variability and complexity. It requires accurate assessment at the preoperative stage (CT scanning) to be ready for reconstruction of any complexity.
{"title":"Efferent blood supply to the right hepatic lobe regarding its transplantation from a living donor: variant anatomy, classification. Part 1","authors":"S. Voskanyan, I. Kolyshev, A. Bashkov, A. Artemiev, V. Rudakov, M. Shabalin, A. Maltseva, M. Popov, A. Sushkov, G. V. Vohmyanin","doi":"10.16931/1995-5464.2023-1-10-24","DOIUrl":"https://doi.org/10.16931/1995-5464.2023-1-10-24","url":null,"abstract":"Aim. To describe new data and to complement the existing information about the anatomic features of the hepatic vein structure in the donor of the right hepatic lobe, to formulate the principles of donor selection proceeding from vascular anatomy.Materials and methods. 306 liver transplantations from living related donors were performed at A.I. Burnazyan Federal Medical Biophysical Center of Federal Medical and Biological Agency of Russia from 2009 to 2021. The vascular anatomy of 518 potential donors was analyzed. The prevalence of different vein structures of the right hepatic lobe was assessed.Results. The authors identified 14 subtypes of anatomy of efferent vessels. They were classified into 3 types depending on the contribution of the median vein to the blood outflow from the right hepatic lobe: caval (67.3%), cava medial (semi-separate, 29%), and separate (3.6%).Conclusion. The anatomy of the efferent vessels of the right lobe graft is characterized by variability and complexity. It requires accurate assessment at the preoperative stage (CT scanning) to be ready for reconstruction of any complexity.","PeriodicalId":36549,"journal":{"name":"Annals of HPB Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49146710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-19DOI: 10.16931/1995-5464.2023-1-97-103
A. D. Kovalevskii, M. Prudkov
The present paper describes clinical observation of successful treatment of a patient with chronic calcifying pancreatitis complicated by an external pancreatic fistula. Abdominal surgery after laparotomy and cholecystectomy had to be limited to bursoomentostomy due to the bleeding tissues and severe blood loss. Combined endoscopic intervention through the external pancreatic fistula was used for the treatment. The performed interventions included stone extraction in Wirsung’s duct, dilation and stenting of the distal stricture of the pancreatic duct. The fistula closed, a pain-free period lasted for 3 years. Similar transfistula interventions were performed in 7 patients with chronic pancreatitis and external pancreatic fistulas, lithiasis in Wirsung's duct (n = 5) and pancreatic duct strictures (n = 6). A total of 17 procedures were performed, 7 of 8 fistulas were closed. Complications developed in 3 observations, no lethal outcome was registered.Conclusion. Transfistula interventions in pancreatic ducts with combined X-ray guidance, oral and transfistula endoscopy can be used to remove stones, dilate strictures and restore natural passage of pancreatic secretions as an independent treatment or preparation for planned abdominal surgery.
{"title":"Combined interventions on pancreatic ducts with external fistulas","authors":"A. D. Kovalevskii, M. Prudkov","doi":"10.16931/1995-5464.2023-1-97-103","DOIUrl":"https://doi.org/10.16931/1995-5464.2023-1-97-103","url":null,"abstract":"The present paper describes clinical observation of successful treatment of a patient with chronic calcifying pancreatitis complicated by an external pancreatic fistula. Abdominal surgery after laparotomy and cholecystectomy had to be limited to bursoomentostomy due to the bleeding tissues and severe blood loss. Combined endoscopic intervention through the external pancreatic fistula was used for the treatment. The performed interventions included stone extraction in Wirsung’s duct, dilation and stenting of the distal stricture of the pancreatic duct. The fistula closed, a pain-free period lasted for 3 years. Similar transfistula interventions were performed in 7 patients with chronic pancreatitis and external pancreatic fistulas, lithiasis in Wirsung's duct (n = 5) and pancreatic duct strictures (n = 6). A total of 17 procedures were performed, 7 of 8 fistulas were closed. Complications developed in 3 observations, no lethal outcome was registered.Conclusion. Transfistula interventions in pancreatic ducts with combined X-ray guidance, oral and transfistula endoscopy can be used to remove stones, dilate strictures and restore natural passage of pancreatic secretions as an independent treatment or preparation for planned abdominal surgery.","PeriodicalId":36549,"journal":{"name":"Annals of HPB Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44877996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-19DOI: 10.16931/1995-5464.2023-1-80-87
I. Vervekin, A. Trushin, R. Kursenko, D. A. Zaitsev, A. Zakharenko
{"title":"Neoadjuvant chemotherapy for resectable pancreatic cancer: a new standard of care?","authors":"I. Vervekin, A. Trushin, R. Kursenko, D. A. Zaitsev, A. Zakharenko","doi":"10.16931/1995-5464.2023-1-80-87","DOIUrl":"https://doi.org/10.16931/1995-5464.2023-1-80-87","url":null,"abstract":"","PeriodicalId":36549,"journal":{"name":"Annals of HPB Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47377604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-15DOI: 10.16931/1995-5464.2022-4-71-83
S. Voskanyan, A. Artemiev, E. Naidenov, K. Gubarev, I. Kolyshev, V. Rudakov, D. Zabezhinsky, A. Bashkov, A. Sushkov, M. Popov, M. M. Fozilov, D. Svetlakova, A. Maltseva
Aim. To develop a universal technology of thrombectomy from the veins of the mesenteric portal system and to evaluate the outcomes of liver transplantation for cirrhosis combined with non-tumorous portal vein thrombosis.Materials and methods. Immediate and long-term results of 309 transplantations in patients with liver cirrhosis of various etiologies were studied. In 46 cases (14.9%), transplantation was performed in patients with liver cirrhosis and concomitant thrombosis in the veins of the mesenteric portal system. Results. A versatile method of thrombectomy, depending on the degree of thrombosis in the veins of the mesenteric portal system was proposed (M.A. Yerdel et al., 2000). Mesenteric portal vein thrombosis increased duration of transplantation and volume of intraoperative blood loss as compared to patients without concomitant thrombosis. No statistically significant differences were found in the overall incidence of postoperative complications, hospital mortality and duration of hospitalization of the patients after liver transplantation with concomitant venous thrombosis compared to the patients without thrombosis. The incidence of thrombotic complications, including hepatic artery thrombosis, was significantly higher after liver transplantation supplemented with thrombectomy from the portal vein system. Five-year survival rate of the patients after liver transplantation with concomitant thrombosis in the veins of the mesenteric portal system was 94.9% (median – 40 months), patients without thrombosis in the veins of the mesenteric portal system – 93.2% (median – 60 months).Conclusion. Transplantation in patients with cirrhosis and thrombosis in the veins of the mesenteric-portal system shows good immediate and long-term results in case proper thrombectomy is carried out.
{"title":"Liver transplantation for cirrhosis complicated by non-tumor thrombosis of mesenteric portal system","authors":"S. Voskanyan, A. Artemiev, E. Naidenov, K. Gubarev, I. Kolyshev, V. Rudakov, D. Zabezhinsky, A. Bashkov, A. Sushkov, M. Popov, M. M. Fozilov, D. Svetlakova, A. Maltseva","doi":"10.16931/1995-5464.2022-4-71-83","DOIUrl":"https://doi.org/10.16931/1995-5464.2022-4-71-83","url":null,"abstract":"Aim. To develop a universal technology of thrombectomy from the veins of the mesenteric portal system and to evaluate the outcomes of liver transplantation for cirrhosis combined with non-tumorous portal vein thrombosis.Materials and methods. Immediate and long-term results of 309 transplantations in patients with liver cirrhosis of various etiologies were studied. In 46 cases (14.9%), transplantation was performed in patients with liver cirrhosis and concomitant thrombosis in the veins of the mesenteric portal system. Results. A versatile method of thrombectomy, depending on the degree of thrombosis in the veins of the mesenteric portal system was proposed (M.A. Yerdel et al., 2000). Mesenteric portal vein thrombosis increased duration of transplantation and volume of intraoperative blood loss as compared to patients without concomitant thrombosis. No statistically significant differences were found in the overall incidence of postoperative complications, hospital mortality and duration of hospitalization of the patients after liver transplantation with concomitant venous thrombosis compared to the patients without thrombosis. The incidence of thrombotic complications, including hepatic artery thrombosis, was significantly higher after liver transplantation supplemented with thrombectomy from the portal vein system. Five-year survival rate of the patients after liver transplantation with concomitant thrombosis in the veins of the mesenteric portal system was 94.9% (median – 40 months), patients without thrombosis in the veins of the mesenteric portal system – 93.2% (median – 60 months).Conclusion. Transplantation in patients with cirrhosis and thrombosis in the veins of the mesenteric-portal system shows good immediate and long-term results in case proper thrombectomy is carried out.","PeriodicalId":36549,"journal":{"name":"Annals of HPB Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41383654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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