Pub Date : 2022-12-15DOI: 10.16931/1995-5464.2022-4-110-116
M. A. Sudakov, I. Kazakov, A. Koroleva, I. M. Borovkov, M. Efanov
The authors introduced a literature review of the Textbook Outcome model and its effectiveness for assessing outcomes of liver resection. The disadvantages of this measuring system were also disclosed. Based on the data obtained, the authors suggested the options to optimize the Textbook Outcome model in terms of meaningful assessment of surgical quality.
{"title":"Evolution of Textbook Outcome in comprehensive assessment of immediate results of liver resection. Current situation","authors":"M. A. Sudakov, I. Kazakov, A. Koroleva, I. M. Borovkov, M. Efanov","doi":"10.16931/1995-5464.2022-4-110-116","DOIUrl":"https://doi.org/10.16931/1995-5464.2022-4-110-116","url":null,"abstract":"The authors introduced a literature review of the Textbook Outcome model and its effectiveness for assessing outcomes of liver resection. The disadvantages of this measuring system were also disclosed. Based on the data obtained, the authors suggested the options to optimize the Textbook Outcome model in terms of meaningful assessment of surgical quality.","PeriodicalId":36549,"journal":{"name":"Annals of HPB Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43712187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-15DOI: 10.16931/1995-5464.2022-4-57-70
O. Ivanova, G. Akhaladze, S. Goncharov, E. N. Grebenkin, U. S. Stanojevic, V. Solodkiy
Aim. To analyze studies focused on comparing laparoscopic and open simultaneous surgeries for synchronous metastases of colorectal cancer in the liver.Materials and methods. The electronic databases PubMed, Web of Science, Scopus, Embase, Cochrane Library were searched for the studies focused on the comparison of open and laparoscopic simultaneous surgeries for synchronous metastatic liver lesions, dated till October 20, 2020. Keywords: simultaneous resections, colorectal cancer, liver metastases, simultaneous laparoscopic.Results. Meta-analysis contains the results of 1211 simultaneous surgeries for simultaneous metastases of colorectal cancer in the liver: 450 laparoscopic and 761 open surgeries. Laparoscopic surgery was characterized with lower blood loss [weighted mean difference (WMD) = -131.77, 95% CI: -232.54 to -31.00, p = 0.01], a shorter postoperative hospitalization [WMD = -2.87, 95% CI: -3.41 to -2. 33, p < 0.00001], early first bowel movement [WMD = -0.99, 95% CI: -1.40 to -0.58, p < 0.0001], early initiation of enteral feeding [WMD = -1.20, 95% CI: -2.06 to -0.33, p = 0.007]), lower incidence of postoperative complications [OR = 0.60, 95% CI: 0.46–0.80, p = 0.0004]. A statistically significant advantage of laparoscopic access was established in overall [OR = 0.80, 95% CI: 0.64–0.99, p = 0.04] and recurrence-free survival [OR = 0.73, 95% CI: 0.60–0.89, p = 0.002].Conclusion. Perioperative and distant oncologic outcomes demonstrate safety and efficacy of laparoscopic simultaneous interventions for synchronous metastases of colorectal cancer in comparison with open interventions.
目标对腹腔镜和开放式同时手术治疗癌症肝同步转移的研究进行分析。材料和方法。在电子数据库PubMed、Web of Science、Scopus、Embase、Cochrane Library中搜索了截至2020年10月20日的研究，这些研究侧重于同步转移性肝损伤的开放式和腹腔镜同时手术的比较。关键词：同时切除，癌症，肝转移，同时腹腔镜。后果Meta-analysis包含1211例同时手术治疗癌症肝转移的结果：450例腹腔镜手术和761例开放手术。腹腔镜手术的特点是失血量较低[加权平均差（WMD）=-131.77，95%CI:-232.54至-31.00，p=0.01]，术后住院时间较短[WMD=-2.87，95%CI:-3.41至-2。33，p<0.00001]，早期首次排便[MWMD=-0.99，95%CI:1.40至-0.58，p<.0001]，早期开始肠内喂养[MWMD=-1.20，95%CI:2.06至-0.33，p=0.007]），术后并发症发生率较低[OR=0.60，95%CI:0.46–0.80，p=0.0004]。腹腔镜入路在总体上具有统计学显著优势[OR=0.80，95%CI=0.64–0.99，p=0.04]和无复发生存率[OR=0.73，95%CI:0.60–0.89，p=0.002]腹腔镜同时介入治疗癌症同步转移与开放式介入治疗的比较。
{"title":"Comparison of laparoscopic and open simultaneous surgeries for synchronous metastases of colorectal cancer in the liver: meta-analysis","authors":"O. Ivanova, G. Akhaladze, S. Goncharov, E. N. Grebenkin, U. S. Stanojevic, V. Solodkiy","doi":"10.16931/1995-5464.2022-4-57-70","DOIUrl":"https://doi.org/10.16931/1995-5464.2022-4-57-70","url":null,"abstract":"Aim. To analyze studies focused on comparing laparoscopic and open simultaneous surgeries for synchronous metastases of colorectal cancer in the liver.Materials and methods. The electronic databases PubMed, Web of Science, Scopus, Embase, Cochrane Library were searched for the studies focused on the comparison of open and laparoscopic simultaneous surgeries for synchronous metastatic liver lesions, dated till October 20, 2020. Keywords: simultaneous resections, colorectal cancer, liver metastases, simultaneous laparoscopic.Results. Meta-analysis contains the results of 1211 simultaneous surgeries for simultaneous metastases of colorectal cancer in the liver: 450 laparoscopic and 761 open surgeries. Laparoscopic surgery was characterized with lower blood loss [weighted mean difference (WMD) = -131.77, 95% CI: -232.54 to -31.00, p = 0.01], a shorter postoperative hospitalization [WMD = -2.87, 95% CI: -3.41 to -2. 33, p < 0.00001], early first bowel movement [WMD = -0.99, 95% CI: -1.40 to -0.58, p < 0.0001], early initiation of enteral feeding [WMD = -1.20, 95% CI: -2.06 to -0.33, p = 0.007]), lower incidence of postoperative complications [OR = 0.60, 95% CI: 0.46–0.80, p = 0.0004]. A statistically significant advantage of laparoscopic access was established in overall [OR = 0.80, 95% CI: 0.64–0.99, p = 0.04] and recurrence-free survival [OR = 0.73, 95% CI: 0.60–0.89, p = 0.002].Conclusion. Perioperative and distant oncologic outcomes demonstrate safety and efficacy of laparoscopic simultaneous interventions for synchronous metastases of colorectal cancer in comparison with open interventions.","PeriodicalId":36549,"journal":{"name":"Annals of HPB Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45321226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-20DOI: 10.16931/1995-5464.2022-3-108-113
O. Vorontsov, T. Mueller, B. Radeleff, I. Mikhin, C. Graeb
The paper presents a description of long-term minimally invasive treatment of a patient with chronic biliary pancreatitis. The treatment consisted in stenting the pancreatic duct with plastic stents, their replacement, bougienage of strictures, drainage of a festering pancreatic pseudocyst, and lithoextraction from the common bile duct. A multidisciplinary assessment of gradually developing complications was not performed. No discussions with pancreatic surgeons on indications for radical resection intervention were held. This treatment strategy led to the syndrome of chronic abdominal pain, recurrent complications after endoscopic minimally invasive treatment, as well as to a significant deterioration in the quality of life. The patient developed depression. Clinical observation clearly demonstrates that it is only possible to determine the optimal timing and indications for resection intervention on the pancreas in complicated chronic pancreatitis within the framework of an interdisciplinary approach.
{"title":"Retrospective assessment of the possibilities of minimally invasive interventions in cases of complicated chronic pancreatitis","authors":"O. Vorontsov, T. Mueller, B. Radeleff, I. Mikhin, C. Graeb","doi":"10.16931/1995-5464.2022-3-108-113","DOIUrl":"https://doi.org/10.16931/1995-5464.2022-3-108-113","url":null,"abstract":"The paper presents a description of long-term minimally invasive treatment of a patient with chronic biliary pancreatitis. The treatment consisted in stenting the pancreatic duct with plastic stents, their replacement, bougienage of strictures, drainage of a festering pancreatic pseudocyst, and lithoextraction from the common bile duct. A multidisciplinary assessment of gradually developing complications was not performed. No discussions with pancreatic surgeons on indications for radical resection intervention were held. This treatment strategy led to the syndrome of chronic abdominal pain, recurrent complications after endoscopic minimally invasive treatment, as well as to a significant deterioration in the quality of life. The patient developed depression. Clinical observation clearly demonstrates that it is only possible to determine the optimal timing and indications for resection intervention on the pancreas in complicated chronic pancreatitis within the framework of an interdisciplinary approach.","PeriodicalId":36549,"journal":{"name":"Annals of HPB Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44421674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-20DOI: 10.16931/1995-5464.2022-3-22-32
A. Shabunin, V. Bedin, D. Grekov, M. Tavobilov, P. Drozdov, S. S. Lebedev, A. A. Karpov, G. Chechenin, V. Tsurkan
Aim. To analyze the results of a multidisciplinary approach to the treatment of patients with hepatocellular cancer in a multidisciplinary oncology clinic.Materials and Methods. From 2007 to 2021, 259 patients with hepatocellular cancer were surgically treated in the Department of Liver and Pancreas Surgery of the city clinical hospital named after S.P. Botkin. Liver resections of different extent were performed in 74 (28.6%) patients, radiofrequency ablation – in 19 (7.3%), microwave ablation – in 20 (7.7%), hepatic artery chemoembolization with radiofrequency ablation – in 34 (13.1%), regional chemotherapy – in 104 (40.2%), liver transplantation – in 8 (3.1%) patients.Results. The overall five- and ten-year survival after liver resection was 51.4% and 31.1% respectively. The poor prognostic factors following liver resection were age >70 years (p = 0.03), postoperative complications (p = 0.04), lymph node metastases (p = 0.01), and a body mass index >30 kg/m2 (p = 0.045). Complications that developed after radiofrequency (microwave) ablation and chemoembolization of the hepatic artery with radiofrequency ablation were 5.1% and 5.8%. Within 90 days after liver resection, three (1.1%) patients died. Complications after resection developed in 18 (24.3%) cases during the same period. With metastases measuring ≤3 cm, the overall five-year survival after radiofrequency and microwave ablation was 36.8% and 35% respectively. With neoplasms measuring 3–5 cm, the best five-year survival was after hepatic artery chemoembolization and radiofrequency ablation (44.1%). The overall fiveyear survival after hepatic artery chemoembolization was 11.5%. No complications or deaths resulted from liver transplantation. With an average follow-up period of 12.5 months, none of the patients experienced disease recurrence or died.Conclusion. Using a multidisciplinary approach in a multidisciplinary oncology clinic improves the results of treating patients with hepatocellular cancer.
{"title":"Hepatocellular cancer. Current trends and the results in surgical treatment","authors":"A. Shabunin, V. Bedin, D. Grekov, M. Tavobilov, P. Drozdov, S. S. Lebedev, A. A. Karpov, G. Chechenin, V. Tsurkan","doi":"10.16931/1995-5464.2022-3-22-32","DOIUrl":"https://doi.org/10.16931/1995-5464.2022-3-22-32","url":null,"abstract":"Aim. To analyze the results of a multidisciplinary approach to the treatment of patients with hepatocellular cancer in a multidisciplinary oncology clinic.Materials and Methods. From 2007 to 2021, 259 patients with hepatocellular cancer were surgically treated in the Department of Liver and Pancreas Surgery of the city clinical hospital named after S.P. Botkin. Liver resections of different extent were performed in 74 (28.6%) patients, radiofrequency ablation – in 19 (7.3%), microwave ablation – in 20 (7.7%), hepatic artery chemoembolization with radiofrequency ablation – in 34 (13.1%), regional chemotherapy – in 104 (40.2%), liver transplantation – in 8 (3.1%) patients.Results. The overall five- and ten-year survival after liver resection was 51.4% and 31.1% respectively. The poor prognostic factors following liver resection were age >70 years (p = 0.03), postoperative complications (p = 0.04), lymph node metastases (p = 0.01), and a body mass index >30 kg/m2 (p = 0.045). Complications that developed after radiofrequency (microwave) ablation and chemoembolization of the hepatic artery with radiofrequency ablation were 5.1% and 5.8%. Within 90 days after liver resection, three (1.1%) patients died. Complications after resection developed in 18 (24.3%) cases during the same period. With metastases measuring ≤3 cm, the overall five-year survival after radiofrequency and microwave ablation was 36.8% and 35% respectively. With neoplasms measuring 3–5 cm, the best five-year survival was after hepatic artery chemoembolization and radiofrequency ablation (44.1%). The overall fiveyear survival after hepatic artery chemoembolization was 11.5%. No complications or deaths resulted from liver transplantation. With an average follow-up period of 12.5 months, none of the patients experienced disease recurrence or died.Conclusion. Using a multidisciplinary approach in a multidisciplinary oncology clinic improves the results of treating patients with hepatocellular cancer.","PeriodicalId":36549,"journal":{"name":"Annals of HPB Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44686838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-20DOI: 10.16931//1995-5464.2022-3-13-21
M. Efanov, R. Alikhanov, I. Kazakov, N. Britskaia, Y. Kulezneva, O. Melekhina, A. Vankovich, A. Koroleva, N. Kulikova, E. Zamanov, V. Tsvirkun, I. Khatkov
Aim. To evaluate short- and long-term results of laparoscopic and open surgeries for intrahepatic cholangiocellular carcinoma.Materials and Methods. The paper presents the retrospectively studied results of laparoscopic and open liver resections in 53 patients (2015–2020). The selection of patients for laparoscopic surgery consisted in maintaining the possibility of performing an R0 resection. A comparison was made before and after the alignment of the groups in relation to the complexity of resection due to the exclusion of resections and the reconstructions of vessels and bile ducts.Results. 53 patients were operated on; 19 patients underwent laparoscopic resection. In the open group, resection and reconstruction of vessels and bile ducts were performed significantly more often. A significantly lower incidence of severe complications and bile leakage was noted in the laparoscopic group, which did not affect the duration of hospital stay. After eliminating the differences in resection complexity, the comparison showed lower blood loss and biliary complications as well as a higher R0 resection rate in the laparoscopic group. The overall and recurrence-free four-year survival did not differ in the groups before and after aligning in terms of resection complexity.Conclusion. The first experience of using laparoscopic access for intrahepatic cholangiocellular carcinoma indicates that it is possible to improve the immediate results of treatment without worsening short- and long-term oncological outcomes.
{"title":"Short- and long-term outcomes of laparoscopic resections for intrahepatic cholangiocellular carcinoma","authors":"M. Efanov, R. Alikhanov, I. Kazakov, N. Britskaia, Y. Kulezneva, O. Melekhina, A. Vankovich, A. Koroleva, N. Kulikova, E. Zamanov, V. Tsvirkun, I. Khatkov","doi":"10.16931//1995-5464.2022-3-13-21","DOIUrl":"https://doi.org/10.16931//1995-5464.2022-3-13-21","url":null,"abstract":"Aim. To evaluate short- and long-term results of laparoscopic and open surgeries for intrahepatic cholangiocellular carcinoma.Materials and Methods. The paper presents the retrospectively studied results of laparoscopic and open liver resections in 53 patients (2015–2020). The selection of patients for laparoscopic surgery consisted in maintaining the possibility of performing an R0 resection. A comparison was made before and after the alignment of the groups in relation to the complexity of resection due to the exclusion of resections and the reconstructions of vessels and bile ducts.Results. 53 patients were operated on; 19 patients underwent laparoscopic resection. In the open group, resection and reconstruction of vessels and bile ducts were performed significantly more often. A significantly lower incidence of severe complications and bile leakage was noted in the laparoscopic group, which did not affect the duration of hospital stay. After eliminating the differences in resection complexity, the comparison showed lower blood loss and biliary complications as well as a higher R0 resection rate in the laparoscopic group. The overall and recurrence-free four-year survival did not differ in the groups before and after aligning in terms of resection complexity.Conclusion. The first experience of using laparoscopic access for intrahepatic cholangiocellular carcinoma indicates that it is possible to improve the immediate results of treatment without worsening short- and long-term oncological outcomes.","PeriodicalId":36549,"journal":{"name":"Annals of HPB Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48661225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-20DOI: 10.16931/1995-5464.2022-3-33-45
S. Voskanyan, A. Artemiev, E. Naidenov, D. Zabezhinsky, M. Shabalin, M. Popov, A. Bashkov, K. Gubarev, V. Rudakov, E. V. Vidmer, A. S. Zhurbin
Neuroendocrine tumors are a rare and heterogeneous group of neoplasms with different malignant potential. They often metastasize to the liver and require active combined therapy. For unresectable neuroendocrine tumors with liver metastases, transplantation has become a potential definitive treatment due to the slow growth and the clinical course of the metastatic process. We conducted a review of relevant literature, the criteria for including and excluding patients considered for liver transplantation as well as alternative methods of treatment of neuroendocrine tumors. The paper presents a clinical observation of a staged combined therapy of a patient with a neuroendocrine tumor of the small intestine and bilobar unresectable liver metastases. The study demonstrates satisfactory long-term results of liver transplantation.
{"title":"Liver transplantation for metastases from neuroendocrine tumors: a literature review and clinical observation","authors":"S. Voskanyan, A. Artemiev, E. Naidenov, D. Zabezhinsky, M. Shabalin, M. Popov, A. Bashkov, K. Gubarev, V. Rudakov, E. V. Vidmer, A. S. Zhurbin","doi":"10.16931/1995-5464.2022-3-33-45","DOIUrl":"https://doi.org/10.16931/1995-5464.2022-3-33-45","url":null,"abstract":"Neuroendocrine tumors are a rare and heterogeneous group of neoplasms with different malignant potential. They often metastasize to the liver and require active combined therapy. For unresectable neuroendocrine tumors with liver metastases, transplantation has become a potential definitive treatment due to the slow growth and the clinical course of the metastatic process. We conducted a review of relevant literature, the criteria for including and excluding patients considered for liver transplantation as well as alternative methods of treatment of neuroendocrine tumors. The paper presents a clinical observation of a staged combined therapy of a patient with a neuroendocrine tumor of the small intestine and bilobar unresectable liver metastases. The study demonstrates satisfactory long-term results of liver transplantation.","PeriodicalId":36549,"journal":{"name":"Annals of HPB Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46053356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-20DOI: 10.16931/1995-5464.2022-3-81-91
A. Fedorov, V. N. Ektov, M. A. Khodorkovskiy
The research review presents literature data on the possibilities of performing minimally invasive necrosectomy for infected forms of acute necrotizing pancreatitis. The paper provides detailed information concerning the terminology, indications for, and technical features of implementing the principal methods of minimally invasive surgical debridement of necrotic accumulations. The techniques include endoscopic transluminal necrosectomy, videoassisted retroperitoneal debridement, and minimally invasive retroperitoneal necrosectomy. The review describes results of numerous studies on the evaluation of their effectiveness and possible options for their combined use. Additionally, we present the materials of relevant international clinical guidelines which indicate the viability of performing minimally invasive necrosectomy as part of a phased strategy for the treatment of patients with acute necrotizing pancreatitis.
{"title":"Transluminal and retroperitoneal minimally invasive necrosectomy in acute pancreatitis","authors":"A. Fedorov, V. N. Ektov, M. A. Khodorkovskiy","doi":"10.16931/1995-5464.2022-3-81-91","DOIUrl":"https://doi.org/10.16931/1995-5464.2022-3-81-91","url":null,"abstract":"The research review presents literature data on the possibilities of performing minimally invasive necrosectomy for infected forms of acute necrotizing pancreatitis. The paper provides detailed information concerning the terminology, indications for, and technical features of implementing the principal methods of minimally invasive surgical debridement of necrotic accumulations. The techniques include endoscopic transluminal necrosectomy, videoassisted retroperitoneal debridement, and minimally invasive retroperitoneal necrosectomy. The review describes results of numerous studies on the evaluation of their effectiveness and possible options for their combined use. Additionally, we present the materials of relevant international clinical guidelines which indicate the viability of performing minimally invasive necrosectomy as part of a phased strategy for the treatment of patients with acute necrotizing pancreatitis.","PeriodicalId":36549,"journal":{"name":"Annals of HPB Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48854304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-20DOI: 10.16931/1995-5464.2022-3-63-67
G. Akhaladze, S. Goncharov, I. D. Lagkueva, V. A. Ragimov, M. M. Dzhigkaeva, Z. E. Baliev
The paper describes a clinical case of pancreaticoduodenectomy for pancreatic ductal adenocarcinoma with superior mesenteric vein resection without its reconstruction. This is the first case study of the kind found in Russian-language literature. In total, 16 such clinical observations have been described in the relevant world literature to date. A 74-year-old female patient was diagnosed with ductal adenocarcinoma of the pancreatic head 1.1 × 1.1 cm in size adjacent to the superior mesenteric vein. After four courses of ineffective neoadjuvant therapy, the tumor completely obliterated the superior mesenteric vein. The control multislice spiral computed tomography (MSCT) showed that the tumor was complete with the formation of a distinct collateral between the superior mesenteric and the inferior mesenteric veins. The patient underwent pancreatoduodenal resection with resection of the involved vein segment without vascular reconstruction. The histopathological diagnosis was pT1cN1M0R0. The patient was discharged on the next day after the operation.
{"title":"Pancreatoduodenectomy with the superior mesenteric vein resection without vascular reconstruction","authors":"G. Akhaladze, S. Goncharov, I. D. Lagkueva, V. A. Ragimov, M. M. Dzhigkaeva, Z. E. Baliev","doi":"10.16931/1995-5464.2022-3-63-67","DOIUrl":"https://doi.org/10.16931/1995-5464.2022-3-63-67","url":null,"abstract":"The paper describes a clinical case of pancreaticoduodenectomy for pancreatic ductal adenocarcinoma with superior mesenteric vein resection without its reconstruction. This is the first case study of the kind found in Russian-language literature. In total, 16 such clinical observations have been described in the relevant world literature to date. A 74-year-old female patient was diagnosed with ductal adenocarcinoma of the pancreatic head 1.1 × 1.1 cm in size adjacent to the superior mesenteric vein. After four courses of ineffective neoadjuvant therapy, the tumor completely obliterated the superior mesenteric vein. The control multislice spiral computed tomography (MSCT) showed that the tumor was complete with the formation of a distinct collateral between the superior mesenteric and the inferior mesenteric veins. The patient underwent pancreatoduodenal resection with resection of the involved vein segment without vascular reconstruction. The histopathological diagnosis was pT1cN1M0R0. The patient was discharged on the next day after the operation.","PeriodicalId":36549,"journal":{"name":"Annals of HPB Surgery","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67614293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-20DOI: 10.16931/1995-5464.2022-3-92-99
A. Kotelnikov, Y. Patyutko, D. Podluzhny, M. S. Saakyan, N. Kudashkin, A. N. Polyakov, P. A. Tikhonov, E. A. Suleimanov, I. Stilidi
The paper presents the results of various studies and meta-analyses which focus on assessing the frequency of formation of clinically significant pancreatic fistulas in various types of pancreatic-digestive anastomoses. Pancreatodigestive anastomosis is not an independent predictive factor of pancreatic complications. None of the modern types of pancreatodigestive anastomosis has proved its superiority. The choice of the pancreatodigestive anastomosis method is based on the correct selection of the organ with which the pancreatic stump is connected and the surgeon’s experience and skill in forming the anastomosis.
{"title":"Pancreatodigestive anastomosis: the key to a favorable outcome of pancreaticoduodenal resection","authors":"A. Kotelnikov, Y. Patyutko, D. Podluzhny, M. S. Saakyan, N. Kudashkin, A. N. Polyakov, P. A. Tikhonov, E. A. Suleimanov, I. Stilidi","doi":"10.16931/1995-5464.2022-3-92-99","DOIUrl":"https://doi.org/10.16931/1995-5464.2022-3-92-99","url":null,"abstract":"The paper presents the results of various studies and meta-analyses which focus on assessing the frequency of formation of clinically significant pancreatic fistulas in various types of pancreatic-digestive anastomoses. Pancreatodigestive anastomosis is not an independent predictive factor of pancreatic complications. None of the modern types of pancreatodigestive anastomosis has proved its superiority. The choice of the pancreatodigestive anastomosis method is based on the correct selection of the organ with which the pancreatic stump is connected and the surgeon’s experience and skill in forming the anastomosis.","PeriodicalId":36549,"journal":{"name":"Annals of HPB Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41941751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-20DOI: 10.16931/1995-5464.2022-3-46-54
V. Zagainov, D. Kuchin, P. Ermakova, E. A. Vasilchikova, L. A. Lugovaia, N. Naraliev, A. V. Kashina
Aim. To develop and implement a method for isolating the islets of Langerhans from pancreatic tissue after pancreatectomy with islet autotransplantation.Materials and Methods. The study used ten Wiesenau miniature pig pancreases, 30 Wistar rat pancreases, eight resected human pancreases, and five human pancreases from extensive resection or pancreatectomy.Results. Islets of Langerhans completely devoid of human and experimental animals’ acinar tissue were obtained. When using the protocol for mechanical isolation, the efficiency of isolating the islets of Langerhans in humans and experimental animals was 50%. The research proved that the isolated cells belonged to the islets of Langerhans. Additionally, their purity was confirmed. The survival of the isolated islets exceeded 90%. The enzyme immunoassay for insulin synthesis showed that the isolated islets of Langerhans remained functionally active. The sterility of the isolated islet cells was confirmed.Conclusion. This proven isolation technology makes it possible to obtain pure, sterile, viable, and functionally active islet cells suitable for further autotransplantation.
{"title":"Islet isolation from the pancreas after pancreatectomy. Indications, methodology, evaluation of results","authors":"V. Zagainov, D. Kuchin, P. Ermakova, E. A. Vasilchikova, L. A. Lugovaia, N. Naraliev, A. V. Kashina","doi":"10.16931/1995-5464.2022-3-46-54","DOIUrl":"https://doi.org/10.16931/1995-5464.2022-3-46-54","url":null,"abstract":"Aim. To develop and implement a method for isolating the islets of Langerhans from pancreatic tissue after pancreatectomy with islet autotransplantation.Materials and Methods. The study used ten Wiesenau miniature pig pancreases, 30 Wistar rat pancreases, eight resected human pancreases, and five human pancreases from extensive resection or pancreatectomy.Results. Islets of Langerhans completely devoid of human and experimental animals’ acinar tissue were obtained. When using the protocol for mechanical isolation, the efficiency of isolating the islets of Langerhans in humans and experimental animals was 50%. The research proved that the isolated cells belonged to the islets of Langerhans. Additionally, their purity was confirmed. The survival of the isolated islets exceeded 90%. The enzyme immunoassay for insulin synthesis showed that the isolated islets of Langerhans remained functionally active. The sterility of the isolated islet cells was confirmed.Conclusion. This proven isolation technology makes it possible to obtain pure, sterile, viable, and functionally active islet cells suitable for further autotransplantation.","PeriodicalId":36549,"journal":{"name":"Annals of HPB Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46946343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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