{"title":"Association between Polymorphisms of X-ray Repair Cross Complementing 5 and 6 Promoter Genes and the Risk of Metastatic Breast Cancer","authors":"Zhaleh Karimi Moghaddam, Samaneh Karimkhanilouei, Golnaz Asaadi Tehrani","doi":"10.30699/jambs.31.144.46","DOIUrl":"https://doi.org/10.30699/jambs.31.144.46","url":null,"abstract":"","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42297253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.30699/jambs.31.144.80
A. Hosseini, Leila Ziaee, Arezoo Rajabian, M. Boroushaki
{"title":"Protective Effect of Pomegranate Seed Oil against D-Galactose-Induced Aging in Rats","authors":"A. Hosseini, Leila Ziaee, Arezoo Rajabian, M. Boroushaki","doi":"10.30699/jambs.31.144.80","DOIUrl":"https://doi.org/10.30699/jambs.31.144.80","url":null,"abstract":"","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41508098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.30699/jambs.31.144.57
I. Shahramian, P. Ostadrahimi, M. Sheikh, S. Nazari, Hadi Mirzarie, A. Moradi, A. Aminisefat, A. Bazi, F. Parooie, M. Tahani
{"title":"Evaluation of S Gene Mutations in Children with Maternally Transmitted Hepatitis B","authors":"I. Shahramian, P. Ostadrahimi, M. Sheikh, S. Nazari, Hadi Mirzarie, A. Moradi, A. Aminisefat, A. Bazi, F. Parooie, M. Tahani","doi":"10.30699/jambs.31.144.57","DOIUrl":"https://doi.org/10.30699/jambs.31.144.57","url":null,"abstract":"","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45463718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.30699/jambs.31.144.32
Soleiman Gharanjik, Morteza Motedayen, Reza Hasanzadeh Makoui, N. Motamed, Minoo Emami, Armin Bordbar, Mohammad Reza Jamshidi, Reza Madadi
{"title":"Comparison of the Success Rate of Treatment with Primary Percutaneous Coronary Intervention PCI versus Thrombolytic Treatment in Patients with ST-Elevation Myocardial Infarction in Local Hospitals in Iran","authors":"Soleiman Gharanjik, Morteza Motedayen, Reza Hasanzadeh Makoui, N. Motamed, Minoo Emami, Armin Bordbar, Mohammad Reza Jamshidi, Reza Madadi","doi":"10.30699/jambs.31.144.32","DOIUrl":"https://doi.org/10.30699/jambs.31.144.32","url":null,"abstract":"","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42842375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.30699/jambs.30.143.561
Sobhan Kasraeifar, Amin Mokhtari-Zaer, Narges Marefati, H. Rakhshandeh, M. Hosseini
10.30699/jambs.30.143.561 Background & Objective: Datura stramonium L. is a medicinal herb from the family of Solanaceae. It has been used in herbal remedies for promoting health and treating several diseases. The current study was set up to compare the effects of Datura stramonium L. extract on the naloxone-precipitated opiate-withdrawal in mice. Materials & Methods: Male BALB/c mice (30– 35 g, n = 40) were arbitrarily separated into 4 groups. The control group received morphine and normal saline and other groups received three doses of D. stramonium extract (10, 20, or 30 mg/kg, intraperitoneally, i.p.). Physically dependent was made by the administration of morphine in increasing doses (50-75 mg/kg, i.p.). The withdrawal signs were elicited by intraperitoneal injections of naloxone (5 mg/kg) 2 h after the last injection of morphine. Results: Administration of D. stramonium extract in doses of 20 and 30 mg/kg markedly diminished the jumping numbers compared to the control group (P<0.05). All three doses of D. stramonium extract could significantly suppress the increase in climbing (P<0.05, P<0.001, and P<0.001, respectively) and diarrhea (P<0.001). D. stramonium in higher doses (20 or 30 mg/kg) significantly decreased rearing and itching (P<0.001). Conclusion: The study findings suggest that D. stramonium extract is effective in alleviating the signs of morphine withdrawal. Additional research is needed to determine the exact mechanisms underlying D. stramonium for inhibiting morphine withdrawal syndrome.
{"title":"Suppressive Effects of the Aerial Parts of Datura Stramonium L. Extract on Naloxone-Precipitated Morphine Withdrawal Signs in Mice","authors":"Sobhan Kasraeifar, Amin Mokhtari-Zaer, Narges Marefati, H. Rakhshandeh, M. Hosseini","doi":"10.30699/jambs.30.143.561","DOIUrl":"https://doi.org/10.30699/jambs.30.143.561","url":null,"abstract":"10.30699/jambs.30.143.561 Background & Objective: Datura stramonium L. is a medicinal herb from the family of Solanaceae. It has been used in herbal remedies for promoting health and treating several diseases. The current study was set up to compare the effects of Datura stramonium L. extract on the naloxone-precipitated opiate-withdrawal in mice. Materials & Methods: Male BALB/c mice (30– 35 g, n = 40) were arbitrarily separated into 4 groups. The control group received morphine and normal saline and other groups received three doses of D. stramonium extract (10, 20, or 30 mg/kg, intraperitoneally, i.p.). Physically dependent was made by the administration of morphine in increasing doses (50-75 mg/kg, i.p.). The withdrawal signs were elicited by intraperitoneal injections of naloxone (5 mg/kg) 2 h after the last injection of morphine. Results: Administration of D. stramonium extract in doses of 20 and 30 mg/kg markedly diminished the jumping numbers compared to the control group (P<0.05). All three doses of D. stramonium extract could significantly suppress the increase in climbing (P<0.05, P<0.001, and P<0.001, respectively) and diarrhea (P<0.001). D. stramonium in higher doses (20 or 30 mg/kg) significantly decreased rearing and itching (P<0.001). Conclusion: The study findings suggest that D. stramonium extract is effective in alleviating the signs of morphine withdrawal. Additional research is needed to determine the exact mechanisms underlying D. stramonium for inhibiting morphine withdrawal syndrome.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47341543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.30699/jambs.30.143.471
Forooz Keshani, Sara Rashed, M. J. Tarahi, L. Maleki
10.30699/jambs.30.143.471 Background & Objective: Oral cancer is one of the 10 most common cancers in the world and its global outbreak is increasing. Saliva assessment is one of the noninvasive diagnostic methods for this cancer. The aim of the study was to achieve a comprehensive conclusion about changes in salivary antioxidants in patients with squamous cell carcinoma of the mouth (OSCC). Materials & Methods: In the present study, as a systematic review and meta-analysis study, information extracted by searching in external databases (PubMed, Science Direct, Scopus, Web of Science, google scholar) and internal databases (IranMedex, Scientific Information Database, Magiran) between the years 1980 to 2020. Comprehensive meta-analysis version 2 software was used to analyze the data (P <0.05). Results: Of 497 articles, 271 duplicate articles were deleted, and then, after reviewing the titles and abstracts of the articles, another 197 articles were removed. The full text of 26 articles were reviewed and evaluated. Finally, based on the STROB checklist, the data of 10 articles were entered into the meta-analysis. index levels were much higher in patients with OSCC than in healthy people (P = 0.0001). All salivary antioxidant indexes (TAC) (P=0.003) and GSH glutathione (P=0.008) saliva was significantly lower in patients than in the healthy group and regarding the salivary superoxide dismutase (SOD) index was no significant. Conclusion: In general, antioxidant supplements may be able to help prevent, treat, and improve the prognosis of this disease, which requires further research in this area.
背景与目的:口腔癌是世界上最常见的10种癌症之一，在全球范围内发病率呈上升趋势。唾液检测是一种无创诊断方法。本研究的目的是获得口腔鳞状细胞癌(OSCC)患者唾液抗氧化剂变化的综合结论。材料与方法:本研究是一项系统综述和荟萃分析研究，通过检索1980 - 2020年间的外部数据库(PubMed、Science Direct、Scopus、Web of Science、谷歌scholar)和内部数据库(IranMedex、Scientific information Database、Magiran)提取信息。采用第2版综合meta分析软件对数据进行分析(P <0.05)。结果:497篇文章中，删除了271篇重复的文章，再对文章的标题和摘要进行审核后，又删除了197篇。对26篇文章的全文进行了审查和评价。最后，根据STROB检查表，将10篇文章的数据输入meta分析。OSCC患者的指数水平远高于健康人(P = 0.0001)。患者唾液抗氧化指数(TAC) (P=0.003)和GSH谷胱甘肽(P=0.008)均显著低于健康组，唾液超氧化物歧化酶(SOD)指数差异无统计学意义。结论:总的来说，抗氧化剂补充剂可能有助于预防、治疗和改善该疾病的预后，这需要在该领域进一步研究。
{"title":"Changes in Salivary Antioxidants in Patients with Oral Squamous Cell Carcinoma: Systematic Review Study and Meta-Analysis","authors":"Forooz Keshani, Sara Rashed, M. J. Tarahi, L. Maleki","doi":"10.30699/jambs.30.143.471","DOIUrl":"https://doi.org/10.30699/jambs.30.143.471","url":null,"abstract":"10.30699/jambs.30.143.471 Background & Objective: Oral cancer is one of the 10 most common cancers in the world and its global outbreak is increasing. Saliva assessment is one of the noninvasive diagnostic methods for this cancer. The aim of the study was to achieve a comprehensive conclusion about changes in salivary antioxidants in patients with squamous cell carcinoma of the mouth (OSCC). Materials & Methods: In the present study, as a systematic review and meta-analysis study, information extracted by searching in external databases (PubMed, Science Direct, Scopus, Web of Science, google scholar) and internal databases (IranMedex, Scientific Information Database, Magiran) between the years 1980 to 2020. Comprehensive meta-analysis version 2 software was used to analyze the data (P <0.05). Results: Of 497 articles, 271 duplicate articles were deleted, and then, after reviewing the titles and abstracts of the articles, another 197 articles were removed. The full text of 26 articles were reviewed and evaluated. Finally, based on the STROB checklist, the data of 10 articles were entered into the meta-analysis. index levels were much higher in patients with OSCC than in healthy people (P = 0.0001). All salivary antioxidant indexes (TAC) (P=0.003) and GSH glutathione (P=0.008) saliva was significantly lower in patients than in the healthy group and regarding the salivary superoxide dismutase (SOD) index was no significant. Conclusion: In general, antioxidant supplements may be able to help prevent, treat, and improve the prognosis of this disease, which requires further research in this area.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47770599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.30699/jambs.30.143.573
M. Taghavi, Salar Poorbarat, S. Mollazadeh
SARS-CoV-2 is a novel strain of the coronaviruses posing great challenges to the human immune system. Hence, human innate immunity determines how our body responses to the early infection (1-3). According to the studies, coronavirus can cause a range of symptoms by affecting different organs in the body (4, 5). Currently, our hospital is one of the referral centers of COVID-19 in Iran. We would like to share our findings regarding complete bed rest in the management of moderate COVID-19 cases.
{"title":"The Role of Complete Bed Rest Position In COVID-19 Patient Outcome; Bed Rest And COVID-19","authors":"M. Taghavi, Salar Poorbarat, S. Mollazadeh","doi":"10.30699/jambs.30.143.573","DOIUrl":"https://doi.org/10.30699/jambs.30.143.573","url":null,"abstract":"SARS-CoV-2 is a novel strain of the coronaviruses posing great challenges to the human immune system. Hence, human innate immunity determines how our body responses to the early infection (1-3). According to the studies, coronavirus can cause a range of symptoms by affecting different organs in the body (4, 5). Currently, our hospital is one of the referral centers of COVID-19 in Iran. We would like to share our findings regarding complete bed rest in the management of moderate COVID-19 cases.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41529424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.30699/jambs.30.143.493
A. Hormati, Ali Khanyabi, S. Ahmadpour, F. Alemi, Seyed Saeid Sarkeshikian, Mahboubeh Afifian, Abolfazl Mohammadbeig, M. Ghadir
10.30699/jambs.30.143.493 Background & Objective: Iron overload in the liver can potentially induce nonalcoholic fatty liver disease (NAFLD). In this study, we sought to evaluate the phlebotomy in NAFLD, and compare it with modified life style. Materials & Methods: This randomized, single-blind, clinical trial was carried out to evaluate the efficacy of phlebotomy on liver enzymes and steatosis in NAFLD patients. Forty patients diagnosed with NAFLD were enrolled in the study. Patients were randomized into two groups, including twenty patients in the first group who were under daily consumption of 800 IU vitamin E with modified lifestyle, and the second group who administrated 400 ml phlebotomy at the baseline and fifth month of study alongside the modified lifestyle. Transient elastography (TE) was used to evaluate liver transaminases, hemoglobin, ferritin levels, and liver stiffness prior to and following the intervention. Chi-square and paired t-tests were used to analyze the data, using SPSS v18. Results: In each group, there were 14 men and 6 women. There was no statistically significant difference in demographic features. After the intervention, the mean liver stiffness of the control group increased from 10.38±2.65 kPa before the treatment to 11.40±6.58 kPa, which was not significantly different (P=0.463). The liver stiffness was 11.29±4.71 kPa in the intervention group before the treatment, which was reduced to 8.10±2.36 kPa after the treatment; however, the difference between pre and post-treatment values was statistically significant (P = 0.009). Before and after the treatment, there were no significant differences in the levels of liver enzymes between the two groups. Conclusion: Phlebotomy is a useful treatment for NAFLD patients, and decreased liver stiffness as cirrhosis complication.
{"title":"Outcome of Phlebotomy on Improvement of Liver Enzymes and Steatosis in Non-Alcoholic Fatty Liver Disease: A Randomized, Controlled Trial","authors":"A. Hormati, Ali Khanyabi, S. Ahmadpour, F. Alemi, Seyed Saeid Sarkeshikian, Mahboubeh Afifian, Abolfazl Mohammadbeig, M. Ghadir","doi":"10.30699/jambs.30.143.493","DOIUrl":"https://doi.org/10.30699/jambs.30.143.493","url":null,"abstract":"10.30699/jambs.30.143.493 Background & Objective: Iron overload in the liver can potentially induce nonalcoholic fatty liver disease (NAFLD). In this study, we sought to evaluate the phlebotomy in NAFLD, and compare it with modified life style. Materials & Methods: This randomized, single-blind, clinical trial was carried out to evaluate the efficacy of phlebotomy on liver enzymes and steatosis in NAFLD patients. Forty patients diagnosed with NAFLD were enrolled in the study. Patients were randomized into two groups, including twenty patients in the first group who were under daily consumption of 800 IU vitamin E with modified lifestyle, and the second group who administrated 400 ml phlebotomy at the baseline and fifth month of study alongside the modified lifestyle. Transient elastography (TE) was used to evaluate liver transaminases, hemoglobin, ferritin levels, and liver stiffness prior to and following the intervention. Chi-square and paired t-tests were used to analyze the data, using SPSS v18. Results: In each group, there were 14 men and 6 women. There was no statistically significant difference in demographic features. After the intervention, the mean liver stiffness of the control group increased from 10.38±2.65 kPa before the treatment to 11.40±6.58 kPa, which was not significantly different (P=0.463). The liver stiffness was 11.29±4.71 kPa in the intervention group before the treatment, which was reduced to 8.10±2.36 kPa after the treatment; however, the difference between pre and post-treatment values was statistically significant (P = 0.009). Before and after the treatment, there were no significant differences in the levels of liver enzymes between the two groups. Conclusion: Phlebotomy is a useful treatment for NAFLD patients, and decreased liver stiffness as cirrhosis complication.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49417638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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