Pub Date : 2022-07-01DOI: 10.30699/jambs.30.141.319
M. Shabani, M. Eshaghian, S. Mazloomzadeh
Background & Objective: Selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants are utilized for treatment of post stroke depression, reduced quality of life and poor compliance. This study compared the effects of sertraline and nortriptyline on the quality of life and depression in post-stroke patients. Materials & Methods: This randomized double-blind trial was conducted on 56 stroke patients admitted to Valiasr Hospital in Zanjan, Iran, 2016. Patients were randomly allocated in two groups by simple randomization and received sertraline in one group, nortriptyline in the other and nobody received placebo. Patients were screened for depression using BDI (II) questionnaire and those without depression were entered into study. During follow-up, patients completed a quality of life questionnaire named Nottingham Health Profile (NHP). Data were analysed using repeated measure and Bonferroni tests in SPSS 22. P<0.05 was considered statistically significant. Results: The mean age of patients in sertraline and nortriptyline groups were 61.7 and 63.6, respectively (P=0.194). No significant differences were observed for sex, marital status and education between two groups. The mean score of total quality of life and its dimensions decreased significantly during 6 months for both groups (P=0.001). The effect of sertraline in these reductions was not different from nortriptyline (P=0.60). The proportions of moderate or severe depression were 17.9% and 37.0% in sertraline and nortriptyline groups, respectively (P=0.24). Conclusion: Both sertraline and nortriptyline improved all aspects of quality of life and their effect on prevention of depression was similar. Therefore, the administration of sertraline or nortriptyline could be beneficial in post-stroke patients.
{"title":"The Effect of Sertreline Versus Nortriptyline on Quality of Life and Depression After Stroke:A Randomized Double-Blind Controlled Study","authors":"M. Shabani, M. Eshaghian, S. Mazloomzadeh","doi":"10.30699/jambs.30.141.319","DOIUrl":"https://doi.org/10.30699/jambs.30.141.319","url":null,"abstract":"Background & Objective: Selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants are utilized for treatment of post stroke depression, reduced quality of life and poor compliance. This study compared the effects of sertraline and nortriptyline on the quality of life and depression in post-stroke patients. Materials & Methods: This randomized double-blind trial was conducted on 56 stroke patients admitted to Valiasr Hospital in Zanjan, Iran, 2016. Patients were randomly allocated in two groups by simple randomization and received sertraline in one group, nortriptyline in the other and nobody received placebo. Patients were screened for depression using BDI (II) questionnaire and those without depression were entered into study. During follow-up, patients completed a quality of life questionnaire named Nottingham Health Profile (NHP). Data were analysed using repeated measure and Bonferroni tests in SPSS 22. P<0.05 was considered statistically significant. Results: The mean age of patients in sertraline and nortriptyline groups were 61.7 and 63.6, respectively (P=0.194). No significant differences were observed for sex, marital status and education between two groups. The mean score of total quality of life and its dimensions decreased significantly during 6 months for both groups (P=0.001). The effect of sertraline in these reductions was not different from nortriptyline (P=0.60). The proportions of moderate or severe depression were 17.9% and 37.0% in sertraline and nortriptyline groups, respectively (P=0.24). Conclusion: Both sertraline and nortriptyline improved all aspects of quality of life and their effect on prevention of depression was similar. Therefore, the administration of sertraline or nortriptyline could be beneficial in post-stroke patients.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48225536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
10.30699/jambs.30.141.314 Background & Objective: In- vitro fertilization (IVF) is one of the approved treatment options for infertility. Despite many progresses in this field, its success rate is about 20 -25%. Utilization of drugs which suppress or decrease uterine smooth muscle contraction before embryo transfer, theoretically can improve fertility by increasing implantation rate. This study was designed to evaluate nifedipine administration on embryo transfer success. Materials & Methods: In this double blinded randomized clinical trial, ninety-eight infertile women from primary and secondary causes were included in two groups; one group received placebo and the other group a single dose of 20 mg nifedipine, both thirty minutes before embryo transfer. Primary outcome was defined as clinical pregnancy, and secondary outcomes as live birth, ectopic pregnancy, multiple gestation and abortion. Results: Clinical pregnancy occurred in eighteen patients in the placebo group and in seventeen patients in nifedipine group (OR = 0.91, 0.40-2.09 (95% CI)). Sixteen patients in placebo group and fourteen patients in nifedipine group had successful live births (OR = 0.82, 0.34-1.95 (95% CI)). Multiple gestation (OR = 1.71, 0.24- 11.78 (95% CI)) and abortion (OR = 0.46, 0.07-2.95 (95% CI)) were not different between the two groups. No side effect of drug occurred in any group. Conclusion: single dose of 20 mg nifedipine tablet administered thirty minutes before IVF had no effect on improving clinical pregnancy and live birth rate. Using higher doses, or different regimens in specific patients’ subgroups may have more effect on embryo transfer success.
{"title":"Evaluation of Nifedipine Administration on Embryo Transfer Success Rate: a Randomized Clinical Trial","authors":"Robabeh Mohammadbeigi, Behnam Hedayat, Ayda Fathollahpour, Solmaz Hedayat","doi":"10.30699/jambs.30.141.314","DOIUrl":"https://doi.org/10.30699/jambs.30.141.314","url":null,"abstract":"10.30699/jambs.30.141.314 Background & Objective: In- vitro fertilization (IVF) is one of the approved treatment options for infertility. Despite many progresses in this field, its success rate is about 20 -25%. Utilization of drugs which suppress or decrease uterine smooth muscle contraction before embryo transfer, theoretically can improve fertility by increasing implantation rate. This study was designed to evaluate nifedipine administration on embryo transfer success. Materials & Methods: In this double blinded randomized clinical trial, ninety-eight infertile women from primary and secondary causes were included in two groups; one group received placebo and the other group a single dose of 20 mg nifedipine, both thirty minutes before embryo transfer. Primary outcome was defined as clinical pregnancy, and secondary outcomes as live birth, ectopic pregnancy, multiple gestation and abortion. Results: Clinical pregnancy occurred in eighteen patients in the placebo group and in seventeen patients in nifedipine group (OR = 0.91, 0.40-2.09 (95% CI)). Sixteen patients in placebo group and fourteen patients in nifedipine group had successful live births (OR = 0.82, 0.34-1.95 (95% CI)). Multiple gestation (OR = 1.71, 0.24- 11.78 (95% CI)) and abortion (OR = 0.46, 0.07-2.95 (95% CI)) were not different between the two groups. No side effect of drug occurred in any group. Conclusion: single dose of 20 mg nifedipine tablet administered thirty minutes before IVF had no effect on improving clinical pregnancy and live birth rate. Using higher doses, or different regimens in specific patients’ subgroups may have more effect on embryo transfer success.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48610850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.30699/jambs.30.141.347
S. Ohadian Moghadam, M. Nowroozi, Ali Nowroozi, Asieh Yousefi Kashi
Background & Objective: Despite the critical importance of catheter as an indwelling medical device, its prolonged utilization in hospitalized patients may lead to infection. This study aimed to identify distribution of uropathogenic bacteria isolated from catheterized uro-oncology patients, their biofilm production, and antimicrobial resistance patterns to generally used antibiotics. Materials & Methods: The urine samples of catheterized urology cancer patients were collected for urinalysis and urine culture. Then capability of biofilm production was detected by Congo red agar method, tube method, and microtiter plate assay. Antimicrobial susceptibility test was also performed using the Kirby–Bauer disc diffusion method on Muller–Hinton agar. Subsequently, polymerase chain reaction (PCR) assays were used to detect the biofilm encoding genes. Results: Of the 100 urinary catheter samples, 76 isolates were recovered from urinary catheters of 52 patients. Escherichia coli was established to be the most frequent pathogen isolated from the urine of patients followed by Pseudomonas and Staphylococcus. All of Pseudomonas aeruginosa and Methicillin-resistant Staphylococcus aureus (MRSA) isolates were found to be biofilm producers. All studied isolates were found resistant to ampicillin, amoxicillin, and cephalexin. All biofilm- producer MRSA and Pseudomonas isolates were found to harbor the virulence genes studied. Both imipenem and fosfomycin were the most effective antibiotics against isolated bacteria. Conclusion: In our study virulent pathogens with highly- resistant profile and potential to form biofilm were isolated from uro-oncology patients. Therefore, the current study highlights the significance of antibiotic resistance which can lead to treatment failure.
{"title":"Biofilm Formation, Antimicrobial Resistance and Biofilm-Related Genes among Uropathogens Isolated from Catheterized Uro-Oncology Patients","authors":"S. Ohadian Moghadam, M. Nowroozi, Ali Nowroozi, Asieh Yousefi Kashi","doi":"10.30699/jambs.30.141.347","DOIUrl":"https://doi.org/10.30699/jambs.30.141.347","url":null,"abstract":"Background & Objective: Despite the critical importance of catheter as an indwelling medical device, its prolonged utilization in hospitalized patients may lead to infection. This study aimed to identify distribution of uropathogenic bacteria isolated from catheterized uro-oncology patients, their biofilm production, and antimicrobial resistance patterns to generally used antibiotics. Materials & Methods: The urine samples of catheterized urology cancer patients were collected for urinalysis and urine culture. Then capability of biofilm production was detected by Congo red agar method, tube method, and microtiter plate assay. Antimicrobial susceptibility test was also performed using the Kirby–Bauer disc diffusion method on Muller–Hinton agar. Subsequently, polymerase chain reaction (PCR) assays were used to detect the biofilm encoding genes. Results: Of the 100 urinary catheter samples, 76 isolates were recovered from urinary catheters of 52 patients. Escherichia coli was established to be the most frequent pathogen isolated from the urine of patients followed by Pseudomonas and Staphylococcus. All of Pseudomonas aeruginosa and Methicillin-resistant Staphylococcus aureus (MRSA) isolates were found to be biofilm producers. All studied isolates were found resistant to ampicillin, amoxicillin, and cephalexin. All biofilm- producer MRSA and Pseudomonas isolates were found to harbor the virulence genes studied. Both imipenem and fosfomycin were the most effective antibiotics against isolated bacteria. Conclusion: In our study virulent pathogens with highly- resistant profile and potential to form biofilm were isolated from uro-oncology patients. Therefore, the current study highlights the significance of antibiotic resistance which can lead to treatment failure.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44457103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.30699/jambs.30.140.255
M. Rostami, Ziba Molaei, N. Motamed
10.30699/jambs.30.140.255 Background & Objective: Growth is an important marker of child health. It has been shown recently that a chronic inflammatory condition, known as Environmental Enteric Dysfunction might play a more significant role on growth velocity than clinical infections. The present study aims to investigate the fecal myeloperoxidase concentration (a marker of gut inflammation) and its relationship with growth velocity. Materials & Methods: In this prospective cohort study, 74 children from rural population of Iran (2 to 5 years of age) were randomly included. The heights and weights of the children were measured at a quarterly interval. The stool samples were obtained from all children in order to measure myeloperoxidase (MPO) concentration. The growth velocity was assessed on the basis of height for age Z-score and weight for age Z-score changes. A questionnaire on socioeconomic status was also completed by children’s parents. Results: 82 children aged 2 to 5 years (37 females and 45 males) with mean age of 40.63 ± 12.7 months participated in this study. The mean fecal MPO level was 71.26 ng/ml (Min – Max: 2 – 232.33 ng/ml). There was no significant relationship between fecal myeloperoxidase level and changes in height and weight Z scores. Moreover, there was no significant relationship between socioeconomic status of households and fecal myeloperoxidase level. Conclusion: The mean level of fecal MPO in the present study was lower than similar studies. This significant difference might be mainly due to the better social status of families and environmental conditions of villages in our study.
{"title":"The Relationship between Fecal Myeloperoxidase Concentration and Growth Velocity in 2-5 Year-Old Children in Rural Areas of Zanjan, Iran","authors":"M. Rostami, Ziba Molaei, N. Motamed","doi":"10.30699/jambs.30.140.255","DOIUrl":"https://doi.org/10.30699/jambs.30.140.255","url":null,"abstract":"10.30699/jambs.30.140.255 Background & Objective: Growth is an important marker of child health. It has been shown recently that a chronic inflammatory condition, known as Environmental Enteric Dysfunction might play a more significant role on growth velocity than clinical infections. The present study aims to investigate the fecal myeloperoxidase concentration (a marker of gut inflammation) and its relationship with growth velocity. Materials & Methods: In this prospective cohort study, 74 children from rural population of Iran (2 to 5 years of age) were randomly included. The heights and weights of the children were measured at a quarterly interval. The stool samples were obtained from all children in order to measure myeloperoxidase (MPO) concentration. The growth velocity was assessed on the basis of height for age Z-score and weight for age Z-score changes. A questionnaire on socioeconomic status was also completed by children’s parents. Results: 82 children aged 2 to 5 years (37 females and 45 males) with mean age of 40.63 ± 12.7 months participated in this study. The mean fecal MPO level was 71.26 ng/ml (Min – Max: 2 – 232.33 ng/ml). There was no significant relationship between fecal myeloperoxidase level and changes in height and weight Z scores. Moreover, there was no significant relationship between socioeconomic status of households and fecal myeloperoxidase level. Conclusion: The mean level of fecal MPO in the present study was lower than similar studies. This significant difference might be mainly due to the better social status of families and environmental conditions of villages in our study.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41442125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.30699/jambs.30.140.281
M. Jahanbakhsh, Asal Aghadavodian jolfaee, R. Kelishadi, M. Sattari
10.30699/jambs.30.140.281 Background & Objective: This study was conducted to shed light on the hidden relationships, trends, and patterns of the teenagers’ mental health dataset based on data mining techniques. Materials & Methods: The proposed method has four parts as follows: data preprocessing, data cleaning, target class selection, and extracting rules. The classes included inappropriate, moderate, and acceptable. The rules were extracted separately by implementing ID3, CHAID, and rule induction on the Caspian 5 dataset. Results: It was found that the teenagers who rarely drink carbonated soda and have dinner seven days a week, have acceptable status of mental health. Besides, watching TV and playing computer games for 4 hours or more per week, drinking tea and packaged juices, eating cakes, cookies, pastries, biscuits, and chocolate weekly could lead to inappropriate status of mental health. Conclusion: An attempt to improve health especially in youth is one of the important concerns of every country. The rules express the negative impact of soda on mental health. Besides, it can be concluded that there is a direct relationship between having breakfast and mental health.
{"title":"Extracting the Hidden Patterns Affecting Mental Health through Data Mining Techniques","authors":"M. Jahanbakhsh, Asal Aghadavodian jolfaee, R. Kelishadi, M. Sattari","doi":"10.30699/jambs.30.140.281","DOIUrl":"https://doi.org/10.30699/jambs.30.140.281","url":null,"abstract":"10.30699/jambs.30.140.281 Background & Objective: This study was conducted to shed light on the hidden relationships, trends, and patterns of the teenagers’ mental health dataset based on data mining techniques. Materials & Methods: The proposed method has four parts as follows: data preprocessing, data cleaning, target class selection, and extracting rules. The classes included inappropriate, moderate, and acceptable. The rules were extracted separately by implementing ID3, CHAID, and rule induction on the Caspian 5 dataset. Results: It was found that the teenagers who rarely drink carbonated soda and have dinner seven days a week, have acceptable status of mental health. Besides, watching TV and playing computer games for 4 hours or more per week, drinking tea and packaged juices, eating cakes, cookies, pastries, biscuits, and chocolate weekly could lead to inappropriate status of mental health. Conclusion: An attempt to improve health especially in youth is one of the important concerns of every country. The rules express the negative impact of soda on mental health. Besides, it can be concluded that there is a direct relationship between having breakfast and mental health.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46793768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.30699/jambs.30.140.275
B. Zamani, F. Atoof, Elnaz Mortazavi, M. Shayestehpour
Background & Objective: Monoarthritis is the inflammation of a single joint. There is limited data on the etiology of monorthritis in Iran. This study was aimed to evaluate epidemiologic charecteristics of the patients with monorthritis in Kashan, Iran. Materials & Methods: This cross-sectional study was conducted on 227 patients with monorthritis referred to the rheumatology clinic of Kashan, Iran between 2018 and 2019. General, physical and rheumatological examinations were performed on all patients. synovial fluid samples were analyzed for viscosity, leucocyte count, Gram's staining, culture and microscopic evaluation of crystals. Results: Mean age of the patients at the baseline was 56.1±17.2 years, out of whom 44.1% were male. Acute and chronic monoarthritis cases were 51.5% and 48.5%, respectively. The most common involved joint was the knee (60.7%) followed by the ankle (32.2%). Pseudogout (39.3%) and gout (31.6%) were the most common causes of acute monoarthritis. There was no significant difference in etiology of acute monoarthritis between male and female (P value=0.33). Osteoarthritis (53.50%) and rheumatoid arthritis (25.50%) were the most common causes of chronic arthritis. A significant correlation was obtained between sex and causes of chronic monoarthritis (P value=0.012). Patients with various etiologies of chronic monoarthritis had significantly different mean age (P value<0.001). Conclusion: The knee joint was the most common site affected by monoarthritis. Pseudogout and osteoarthritis were the most common causes of acute and chronic arthritis, respectively.
{"title":"Epidemiologic Evaluation of Patients with Monoarthritis in Kashan, Iran","authors":"B. Zamani, F. Atoof, Elnaz Mortazavi, M. Shayestehpour","doi":"10.30699/jambs.30.140.275","DOIUrl":"https://doi.org/10.30699/jambs.30.140.275","url":null,"abstract":"Background & Objective: Monoarthritis is the inflammation of a single joint. There is limited data on the etiology of monorthritis in Iran. This study was aimed to evaluate epidemiologic charecteristics of the patients with monorthritis in Kashan, Iran. Materials & Methods: This cross-sectional study was conducted on 227 patients with monorthritis referred to the rheumatology clinic of Kashan, Iran between 2018 and 2019. General, physical and rheumatological examinations were performed on all patients. synovial fluid samples were analyzed for viscosity, leucocyte count, Gram's staining, culture and microscopic evaluation of crystals. Results: Mean age of the patients at the baseline was 56.1±17.2 years, out of whom 44.1% were male. Acute and chronic monoarthritis cases were 51.5% and 48.5%, respectively. The most common involved joint was the knee (60.7%) followed by the ankle (32.2%). Pseudogout (39.3%) and gout (31.6%) were the most common causes of acute monoarthritis. There was no significant difference in etiology of acute monoarthritis between male and female (P value=0.33). Osteoarthritis (53.50%) and rheumatoid arthritis (25.50%) were the most common causes of chronic arthritis. A significant correlation was obtained between sex and causes of chronic monoarthritis (P value=0.012). Patients with various etiologies of chronic monoarthritis had significantly different mean age (P value<0.001). Conclusion: The knee joint was the most common site affected by monoarthritis. Pseudogout and osteoarthritis were the most common causes of acute and chronic arthritis, respectively.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41359384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.30699/jambs.30.140.241
N. Nematollahi, M. Mohammadi, M. Vakili, A. Baniaghil, M. Ghelichli, M. Najafi, Atousa Mortazavi Milani, Amir Hossein Ghadirian, Fatemeh Shahrokhi, Hasan Khorshah, S. S. Hosseini
Pub Date : 2022-05-01DOI: 10.30699/jambs.30.140.211
Maryam Allahverdi-Khani, L. Ulloa, M. Motaghinejad, Mahsa Salehirad
A number of studies have previously provided evidence on the Anti-inflammatory properties of plant-derived compounds that can prevent lung injury. In this study, we attempted to analyze the therapeutic effects of PM 014 on inflammation and pulmonary fibrosis in COVID-19 as well as describing the treatment of one of the most challenging problems related to the coronavirus-19 (COVID-19). We believe that having a close look at all angles of the proposed mechanism goes beyond the physiological consequences of a way to design new strategies for providing an appropriate treatment.
{"title":"Standardized Herbal PM014 Formula Ameliorates Pulmonary Fibrosis in COVID-19 Patients by Inhibiting the TGF-β1 Signaling Pathway","authors":"Maryam Allahverdi-Khani, L. Ulloa, M. Motaghinejad, Mahsa Salehirad","doi":"10.30699/jambs.30.140.211","DOIUrl":"https://doi.org/10.30699/jambs.30.140.211","url":null,"abstract":"A number of studies have previously provided evidence on the Anti-inflammatory properties of plant-derived compounds that can prevent lung injury. In this study, we attempted to analyze the therapeutic effects of PM 014 on inflammation and pulmonary fibrosis in COVID-19 as well as describing the treatment of one of the most challenging problems related to the coronavirus-19 (COVID-19). We believe that having a close look at all angles of the proposed mechanism goes beyond the physiological consequences of a way to design new strategies for providing an appropriate treatment.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49209773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.30699/jambs.30.140.249
Alireza Eskandarifar, Anvar Mohammadi Baneh, Hamid Alizadeh
Background & Objective: Chronic kidney disease (CKD) determined by permanent kidney damage. Due to the similarity of clinical symptoms of hypothyroidism with CKD, hypothyroidism may be neglected and remain untreated. The goal of our study was to evaluate the rate of hypothyroidism in CKD patients who need hemodialysis. Materials & Methods: This is a cross-sectional research. The sampling method was census and included all CKD patients in need of hemodialysis, who had undergone hemodialysis for at least three months. Serum levels of thyroid stimulating hormone (TSH), thyroxine (T4) and triiodothyronine (T 3 ) hormones were measured in these patients, then the collected data were statistically analyzed. Results: We studied 108 patients, 58 males (53.7%) and 50 females (46.3%). The mean age of the patients was 61.09 ± 13.45 years. The mean serum levels of hormones were as follows: TSH: 1.64±1.78 µIL/ml, T3:0.88 ± 0.2ng/dl, and T4:7.7±1.6 µg/dl. In this study, 7.4% of the patients had high TSH levels, 3.7% of the patients had decreased T4 levels and 10.2% of the patients had lower than normal T3 levels. Conclusion: The rate of hypothyroidism in CKD patients who needed hemodialysis was higher than the normal population. It is recommended that serum TSH, and T4 levels in CKD patients be measured regularly to detect subclinical hypothyroid cases.
{"title":"Evaluation of Hypothyroidism in Patients with Chronic Kidney Disease in Western Iran","authors":"Alireza Eskandarifar, Anvar Mohammadi Baneh, Hamid Alizadeh","doi":"10.30699/jambs.30.140.249","DOIUrl":"https://doi.org/10.30699/jambs.30.140.249","url":null,"abstract":"Background & Objective: Chronic kidney disease (CKD) determined by permanent kidney damage. Due to the similarity of clinical symptoms of hypothyroidism with CKD, hypothyroidism may be neglected and remain untreated. The goal of our study was to evaluate the rate of hypothyroidism in CKD patients who need hemodialysis. Materials & Methods: This is a cross-sectional research. The sampling method was census and included all CKD patients in need of hemodialysis, who had undergone hemodialysis for at least three months. Serum levels of thyroid stimulating hormone (TSH), thyroxine (T4) and triiodothyronine (T 3 ) hormones were measured in these patients, then the collected data were statistically analyzed. Results: We studied 108 patients, 58 males (53.7%) and 50 females (46.3%). The mean age of the patients was 61.09 ± 13.45 years. The mean serum levels of hormones were as follows: TSH: 1.64±1.78 µIL/ml, T3:0.88 ± 0.2ng/dl, and T4:7.7±1.6 µg/dl. In this study, 7.4% of the patients had high TSH levels, 3.7% of the patients had decreased T4 levels and 10.2% of the patients had lower than normal T3 levels. Conclusion: The rate of hypothyroidism in CKD patients who needed hemodialysis was higher than the normal population. It is recommended that serum TSH, and T4 levels in CKD patients be measured regularly to detect subclinical hypothyroid cases.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41540180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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