Background & Aim: According to globally development of stomach cancer especially in Ardabil, Iran, as the second major cause of mortality throughout the world, increased drug-resistant bacteria including Helicobacter pylori as the most important risk factors for stomach cancer, and side effects of antibiotics and chemical drugs normally used to treat. Experimental: The current research was conducted to investigate the anticancer and antimicrobial effects of native herbs of liquorice (Glycyrrhiza glabra) and pennyroyal (Mentha pulegium) extractions for finding a solution with the lowest complications in control or treatment of stomach cancer.The extractions were firstly obtained using Soxhlet and methanol solvent and then their compounds were determined by GC/MS. Antimicrobial activity, MIC and MBC of the extractions were assessed respectively using agar diffusion and broth dilution test and the anticancer effect on stomach cancer (cell line AGS) was assessed by MTT assay. H. pylori ATCC 26695 was respectively revived and purified on Brucella broth containing 7% citrated horse serum and Columbia agar. Results: The analysis showed that liquorice extract contains 15 compositions, mainly consists of 26.48% Nonane, 23.38% Ethylcyclohexan, 8.29% 3-Bromodecane, 10.31% trans-2-Heptenal, 8.93% 9-Octadecenamide and 4.68% β-pregna and pennyroyal extract contains 17 compositions, mainly including 3.36% Camphor, 22.79% Pulegone, 4.92% Paramenth-3-n8-l, 8.06% Menthoforan, 7.54% Cis-Isopulegon and 24.58% α-Selinene. The bacteria were resistant or semi-sensitive to common antibiotics, whereas had considerable sensitivity to herbal extracts and liquorice showed almost three times more antibacterial effect. Pennyroyal extract had no cytotoxic effects, but the anticancer effect was observed in liquorice extract with optimal concentration of 25 μg/ml after 48 hours. Recommended applications/industries: In conclusion, liquorice extract due to the significant health benefits of anticancer and antibacterial activity can be selective and highly effective herbal medicine as an alternative to antibiotics and other chemical drugs. Type: Original Research Topic: Medicinal Plants Received July 29 2016 Accepted December 1 2016
{"title":"An Investigation of Compositions and Effects of Local Herbal Glycyrrhiza glabra and Mentha pulegium extracts on Helicobacterpylori and Cell Line of stomach Cancer (AGS) by MTT assays","authors":"Fereshteh Salmani Jamaat, H. Yaghoubi","doi":"10.18869/JHD.2017.41","DOIUrl":"https://doi.org/10.18869/JHD.2017.41","url":null,"abstract":"Background & Aim: According to globally development of stomach cancer especially in Ardabil, Iran, as the second major cause of mortality throughout the world, increased drug-resistant bacteria including Helicobacter pylori as the most important risk factors for stomach cancer, and side effects of antibiotics and chemical drugs normally used to treat. Experimental: The current research was conducted to investigate the anticancer and antimicrobial effects of native herbs of liquorice (Glycyrrhiza glabra) and pennyroyal (Mentha pulegium) extractions for finding a solution with the lowest complications in control or treatment of stomach cancer.The extractions were firstly obtained using Soxhlet and methanol solvent and then their compounds were determined by GC/MS. Antimicrobial activity, MIC and MBC of the extractions were assessed respectively using agar diffusion and broth dilution test and the anticancer effect on stomach cancer (cell line AGS) was assessed by MTT assay. H. pylori ATCC 26695 was respectively revived and purified on Brucella broth containing 7% citrated horse serum and Columbia agar. Results: The analysis showed that liquorice extract contains 15 compositions, mainly consists of 26.48% Nonane, 23.38% Ethylcyclohexan, 8.29% 3-Bromodecane, 10.31% trans-2-Heptenal, 8.93% 9-Octadecenamide and 4.68% β-pregna and pennyroyal extract contains 17 compositions, mainly including 3.36% Camphor, 22.79% Pulegone, 4.92% Paramenth-3-n8-l, 8.06% Menthoforan, 7.54% Cis-Isopulegon and 24.58% α-Selinene. The bacteria were resistant or semi-sensitive to common antibiotics, whereas had considerable sensitivity to herbal extracts and liquorice showed almost three times more antibacterial effect. Pennyroyal extract had no cytotoxic effects, but the anticancer effect was observed in liquorice extract with optimal concentration of 25 μg/ml after 48 hours. Recommended applications/industries: In conclusion, liquorice extract due to the significant health benefits of anticancer and antibacterial activity can be selective and highly effective herbal medicine as an alternative to antibiotics and other chemical drugs. Type: Original Research Topic: Medicinal Plants Received July 29 2016 Accepted December 1 2016","PeriodicalId":366512,"journal":{"name":"Journal of Herbal Drugs: International Journal on Medicinal Herbs","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125815524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background & Aim: Some knowledge about medicinal plants is available in old references or books. But important point is the information of traditional usage of medicinal plants from different parts of Iran will be worthwhile and in addition to encouraging people to it provides a good background for future examination about medicinal plants. The objectives of this study is to identify the medicinal plants along with local names, utilized parts, administration route, ailments treated, therapeutic effect and preparation methods. Experimental: So to get this information, we use semi-structured interviews. This research was conducted in the summer and spring of 2016. During this period around 150 individuals (75 men, 75 women; in an age group between 20 and 95 years) were interviewed in 6 villages. Number of questions in this survey was 15 questions. Ethno botanical data were analyzed by use-reports. In addition important indices like Informant Agreement Ratio (IAR), Relative Frequency of Citation (RFC) and Cultural Importance (CI) were calculated. Furthermore, a traditional null hypothesis testing was adopted. These are the most popular indices in quantitative ethno botany. Results: A total of 54 medicinal plants belonging to 22 families were identified. The most common families are Lamiaceae, Asteraceae, Apiaceae and Rosaceae, with 22, 17, 5 and 4%, respectively. The most common preparations methods were infusion (52%), eaten raw and decoction (13%). Also, between different parts of the plant, the leaves are mostly used. According to RFC and CI indices, the most important plant is Gallium verum. Nervous disease has the highest Informant Consensus Factor value with the rate of 0.80. Recommended applications/industries: Introduction of medicinal plants in each region, along with their use can be a great help to create jobs and Encouraging people to cultivate these plants. Type: Original Research Topic: Medicinal Plants Received July 24 2016 Accepted December 16 2016
{"title":"Traditional and local use of medicinal plants by local communities in Hezar Jerib summer area, north of Iran","authors":"Isa Jafari Footami, M. Akbarlou","doi":"10.18869/JHD.2017.27","DOIUrl":"https://doi.org/10.18869/JHD.2017.27","url":null,"abstract":"Background & Aim: Some knowledge about medicinal plants is available in old references or books. But important point is the information of traditional usage of medicinal plants from different parts of Iran will be worthwhile and in addition to encouraging people to it provides a good background for future examination about medicinal plants. The objectives of this study is to identify the medicinal plants along with local names, utilized parts, administration route, ailments treated, therapeutic effect and preparation methods. Experimental: So to get this information, we use semi-structured interviews. This research was conducted in the summer and spring of 2016. During this period around 150 individuals (75 men, 75 women; in an age group between 20 and 95 years) were interviewed in 6 villages. Number of questions in this survey was 15 questions. Ethno botanical data were analyzed by use-reports. In addition important indices like Informant Agreement Ratio (IAR), Relative Frequency of Citation (RFC) and Cultural Importance (CI) were calculated. Furthermore, a traditional null hypothesis testing was adopted. These are the most popular indices in quantitative ethno botany. Results: A total of 54 medicinal plants belonging to 22 families were identified. The most common families are Lamiaceae, Asteraceae, Apiaceae and Rosaceae, with 22, 17, 5 and 4%, respectively. The most common preparations methods were infusion (52%), eaten raw and decoction (13%). Also, between different parts of the plant, the leaves are mostly used. According to RFC and CI indices, the most important plant is Gallium verum. Nervous disease has the highest Informant Consensus Factor value with the rate of 0.80. Recommended applications/industries: Introduction of medicinal plants in each region, along with their use can be a great help to create jobs and Encouraging people to cultivate these plants. Type: Original Research Topic: Medicinal Plants Received July 24 2016 Accepted December 16 2016","PeriodicalId":366512,"journal":{"name":"Journal of Herbal Drugs: International Journal on Medicinal Herbs","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133436782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emeje O. Martins, I. Christianah, Izuka Amaka, O. Olubunmi
Background & Aim: The hot water extract of a mixture of Anogeissus leiocarpus and Prosopis africana is widely used in the northern part of Nigeria for the treatment and management of asthma. Since investigations of its pharmacological activities already justify its use, and the need for standardization of herbal medicine and develop appropriate dosage forms has continued to grow, the purpose of this study was to evaluate the effects of some common channelling agents (sodium bicarbonate, calcium carbonate and sodium lauryl sulphate) on the compaction properties of the mixed stem bark extracts of Anogeissus leiocarpus and Prosopis africana. Experimental: Granules of the mixed extracts (AA1) were produced using the wet granulation method of massing and screening. The micromeritics and flow properties of the extracts as well as the effects of the three common additives were studied, while the compaction properties of the extract formulated alone and in the presence of these additives were interrogated using the Heckel equation. Results: Our results showed that, all the formulations containing the channelling agents exhibited poor flow. Granules prepared using sodium bicarbonate (NaHCO3) exhibited plastic deformation during consolidation, those formulated using calcium carbonate (CaCO3) showed initial fragmentation before consolidation by plastic deformation and those formulated using sodium lauryl sulphate consolidated essentially by plastic deformation. Inclusion of additives modified the compressibility profiles of the formulations. Tensile strength of the formulations containing NaHCO3 and sodium lauryl sulphate (SLS) were observed to be concentration dependent while those containing CaCO3 showed no appreciable increase in tensile strength with increased pressure. Generally, formulations containing 5% of the additives gave the highest tensile strength, however, those containing CaCO3 were found to be higher than the other two formulations. Recommended applications/industries: Considering that, none of the channelling agents altered significantly the compaction properties of AA1, they might be useful in developing standardized and robust tablets of A. leiocarpus and P. africana admixtures for Asthma therapy. Type: Original Research Topic: Medicinal Plants Received February 19 2016 Accepted April 15 2016
{"title":"Effects of some channelling agents on the compaction properties of the mixed stem bark extracts of Anogeissus leiocarpus and Prosopis africana","authors":"Emeje O. Martins, I. Christianah, Izuka Amaka, O. Olubunmi","doi":"10.18869/JHD.2017.9","DOIUrl":"https://doi.org/10.18869/JHD.2017.9","url":null,"abstract":"Background & Aim: The hot water extract of a mixture of Anogeissus leiocarpus and Prosopis africana is widely used in the northern part of Nigeria for the treatment and management of asthma. Since investigations of its pharmacological activities already justify its use, and the need for standardization of herbal medicine and develop appropriate dosage forms has continued to grow, the purpose of this study was to evaluate the effects of some common channelling agents (sodium bicarbonate, calcium carbonate and sodium lauryl sulphate) on the compaction properties of the mixed stem bark extracts of Anogeissus leiocarpus and Prosopis africana. Experimental: Granules of the mixed extracts (AA1) were produced using the wet granulation method of massing and screening. The micromeritics and flow properties of the extracts as well as the effects of the three common additives were studied, while the compaction properties of the extract formulated alone and in the presence of these additives were interrogated using the Heckel equation. Results: Our results showed that, all the formulations containing the channelling agents exhibited poor flow. Granules prepared using sodium bicarbonate (NaHCO3) exhibited plastic deformation during consolidation, those formulated using calcium carbonate (CaCO3) showed initial fragmentation before consolidation by plastic deformation and those formulated using sodium lauryl sulphate consolidated essentially by plastic deformation. Inclusion of additives modified the compressibility profiles of the formulations. Tensile strength of the formulations containing NaHCO3 and sodium lauryl sulphate (SLS) were observed to be concentration dependent while those containing CaCO3 showed no appreciable increase in tensile strength with increased pressure. Generally, formulations containing 5% of the additives gave the highest tensile strength, however, those containing CaCO3 were found to be higher than the other two formulations. Recommended applications/industries: Considering that, none of the channelling agents altered significantly the compaction properties of AA1, they might be useful in developing standardized and robust tablets of A. leiocarpus and P. africana admixtures for Asthma therapy. Type: Original Research Topic: Medicinal Plants Received February 19 2016 Accepted April 15 2016","PeriodicalId":366512,"journal":{"name":"Journal of Herbal Drugs: International Journal on Medicinal Herbs","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128524158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：