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Pneumonitis and Pulmonary Mucormycosis in a Covid-19 Positive Patient-A Case Report. 1例Covid-19阳性患者的肺炎和肺毛霉菌病报告
Q4 Medicine Pub Date : 2022-06-01 DOI: 10.1177/19253621221106885
Luv Sharma, Sumiti Gupta, Lalit Chopra, Pooja Dhamija

In the wake of second wave of coronavirus disease (Covid-19), an increased number of mucormycosis cases were reported by the Ministry of Health and Family Welfare in India. A total of 45 432 cases of mucormycosis were reported till mid-July 2021, with 4252 fatalities. Mucormycosis and other fungal infections are most commonly seen as an opportunistic infection. They are found in those with low underlying immunity either due to a diabetes, cancers particularly hematological malignancies, and so on, or as a side effect of prolonged/irrational use of certain drugs like steroids, immunosuppressive drugs for management of other disorders including Covid-19. The Health Authorities in India stated that although it is not a new disease, its true incidence during the beginning of the second wave was unknown as it was not a notifiable disease. As per reports, the most common presentations of mucormycosis included rhinocerebral (77.6%), cutaneous (4.3%), and pulmonary (3.0%). We present a case of pulmonary mucormycosis and pneumonitis in a Covid-19 positive patient brought for autopsy. The patient was an under trial prisoner sent for treatment to our facility who was reported Covid positive.

在第二波冠状病毒病(Covid-19)之后,印度卫生和家庭福利部报告的毛霉病病例数量有所增加。截至2021年7月中旬,共报告了45 432例毛霉病,其中4252人死亡。毛霉病和其他真菌感染最常被视为机会性感染。它们存在于基础免疫力低下的人群中,要么是由于糖尿病、癌症(特别是血液系统恶性肿瘤)等原因,要么是长期/不合理使用某些药物(如类固醇)、用于治疗包括Covid-19在内的其他疾病的免疫抑制药物的副作用。印度卫生当局指出,虽然这不是一种新疾病,但在第二波开始时,其真实发病率尚不清楚,因为它不是一种必须报告的疾病。根据报告,毛霉菌病最常见的表现包括鼻-脑(77.6%)、皮肤(4.3%)和肺部(3.0%)。我们提出一例肺毛霉菌病和肺炎在Covid-19阳性患者带来尸检。该患者是一名正在受审的囚犯,被送往我们的设施接受治疗,据报告呈Covid阳性。
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引用次数: 0
A Model Medical Examiner Law. 《模范法医法》
Q4 Medicine Pub Date : 2022-06-01 DOI: 10.1177/19253621221097295
Victor W Weedn

Background: Legal systems for medicolegal death investigation in the United States are varied. A 1954 model medical examiner law was initially embraced by a few states but did not gain widespread support and was woefully inadequate. The 2009 National Commission on Forensic Science recommended the creation of an updated model medical examiner legislation.

Methods: Various considerations for policymakers are explored.

Results: A model law is proposed.

背景:美国医学死亡调查的法律制度多种多样。1954年的一项示范法医法最初被一些州接受,但没有得到广泛支持,而且严重不足。2009年全国法医科学委员会建议制定一项更新的法医立法范本。方法:探讨政策制定者的各种考虑因素。结果:提出了一个示范法。
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引用次数: 0
The Intersection of Death Investigation and Organ Donation Systems: A Scoping Review. 死亡调查和器官捐献系统的交叉:范围审查。
Q4 Medicine Pub Date : 2022-06-01 Epub Date: 2022-06-29 DOI: 10.1177/19253621221106892
Mackenzie Cullip, Aimee J Sarti, Matthew J Weiss, Heather Whittingham, Maureen O Meade

Introduction: Death investigators (DIs) such as coroners, medical examiners, and forensic pathologists play important and evolving roles in deceased organ donation. DIs communicate with organ donation organizations (ODOs) to gather case-specific information and release or restrict organs depending on the medicolegal requirements. This scoping review aims to identify the breadth of roles and decision-making processes that may facilitate or hinder deceased donation in DI cases.

Methods: This study was conducted using a scoping literature review and subsequent thematic analysis.

Results: Thirty-one eligible papers described 8 common themes with region-specific nuances. These include: 1) shared (ODO and DI) protocols for early communication around each case; 2) shared standards and education for death investigation practices related to organ donation; 3) DI support staff or teams to facilitate organ donation; 4) DI authority to order additional testing and imaging before organ recovery; 5) donation-specific legislation to enhance DI and/or ODO operations; 6) legally trained DI authority to veto medical decisions to proceed with organ donation; 7) DI attendance at organ recovery; and 8) surgeons recording specific DI evidence during organ recovery.

Conclusion: These findings have cultural and resource-allocation implications and expose gaps in the international literature describing practices at the intersection of deceased organ donation and death investigation. A better understanding of the rationale and execution of various systems for DI and ODO cooperation may serve to advance both organ donation and death investigation.

死亡调查员(DIs),如验尸官、法医和法医病理学家在死者器官捐赠中发挥着重要的和不断发展的作用。与器官捐赠组织(ODOs)沟通,收集具体病例信息,并根据医学法律要求释放或限制器官。这一范围审查的目的是确定可能促进或阻碍死者遗体捐献的角色和决策过程的广度。方法:本研究采用范围文献综述和随后的专题分析。结果:31篇符合条件的论文描述了8个具有区域特异性细微差别的共同主题。这些包括:1)围绕每个案例进行早期通信的共享(ODO和DI)协议;2)与器官捐献相关的死亡调查实践的共享标准和教育;3)辅助人员或团队协助器官捐赠;4) DI有权要求在器官恢复前进行额外的检查和成像;5)针对捐赠的立法,以加强直接捐赠和/或在线捐赠的运作;6)经过合法培训的残障人士有权否决继续进行器官捐赠的医疗决定;7) DI参加器官恢复;8)外科医生在器官恢复过程中记录特定的DI证据。结论:这些发现具有文化和资源分配意义,并揭示了国际文献中描述死者器官捐赠和死亡调查交叉实践的差距。更好地理解DI和ODO合作的各种系统的原理和执行可能有助于推进器官捐赠和死亡调查。
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引用次数: 0
Neonaticides in the United States-2008-2017. 2008-2017年美国新生儿致死事件。
Q4 Medicine Pub Date : 2022-03-01 DOI: 10.1177/19253621221077870
Rebecca F Wilson, Joanne Klevens, Beverly Fortson, Dionne Williams, Likan Xu, Keming Yuan

Objective: This study examines factors associated with homicide in the first 24 hours of life (i.e., neonaticide) in the United States.

Methods: National Vital Statistics System (NVSS) linked birth-infant death data, for 50 states and the District of Columbia, from 2008 through 2017, were used to examine characteristics associated with neonaticide. National Violent Death Reporting System (NVDRS) data were used to examine circumstances of neonaticides that occurred in 14 states. Circumstances of neonaticides are described, and rates for maternal and infant characteristics are presented as rates per 100,000 person-years.

Results: Among neonaticide victims in NVSS (N = 81), those of mothers who are young, unmarried, non-Hispanic, Black, and have lower education levels, are at an increased risk of neonaticide. Further, among mothers in NVDRS who committed neonaticide (N = 42), 66.7% were known to have given birth at a residence, without medical assistance. Approximately three-fourths (73.8%; n = 31) concealed their pregnancy, with 35.7% (n = 15) disposing of their infants in a trash receptacle after giving birth. Additionally, more than half of neonaticide victims were tested for alcohol, opioids, amphetamines, and cocaine, but a relatively small number tested positive for these substances.

Conclusions: Results highlight the importance of identifying factors that elevate risk to neonates so these deaths can be prevented. As such, many mothers who commit neonaticide are young, unmarried, and conceal their pregnancy; thus, programs that prevent teen pregnancy, decrease shame and stigma associated with birth to young mothers, and provide support and resources to pregnant women, may help prevent neonaticide.

目的:本研究探讨了与美国出生后24小时内杀人(即新生儿杀婴)相关的因素。方法:从2008年到2017年,使用国家生命统计系统(NVSS)与50个州和哥伦比亚特区的出生-婴儿死亡数据相关联的数据来检查与新生儿杀婴相关的特征。国家暴力死亡报告系统(NVDRS)的数据被用来检查14个州发生的新生儿杀害事件。描述了新生儿杀害的情况,孕产妇和婴儿特征的比率以每10万人年的比率表示。结果:在NVSS的新生儿杀婴受害者中(N = 81),那些年轻、未婚、非西班牙裔、黑人和教育水平较低的母亲的新生儿杀婴风险增加。此外,在NVDRS中犯下杀害新生儿罪行的母亲(N = 42)中,已知66.7%的母亲在没有医疗援助的情况下在住所分娩。大约四分之三(73.8%;N = 31)隐瞒怀孕,35.7% (N = 15)分娩后将婴儿丢弃在垃圾桶中。此外,半数以上的杀新生儿受害者接受了酒精、阿片类药物、安非他明和可卡因检测,但这些物质检测呈阳性的人数相对较少。结论:结果强调了识别提高新生儿风险因素的重要性,这样可以预防这些死亡。因此,许多杀害新生儿的母亲都很年轻,未婚,并且隐瞒自己的怀孕情况;因此,预防青少年怀孕、减少与年轻母亲分娩相关的羞耻感和污名,以及为孕妇提供支持和资源的项目,可能有助于预防杀婴行为。
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引用次数: 0
Medicolegal Aspects of Victims of Assault Admitted to a Tertiary Care Hospital in Sri Lanka. 斯里兰卡三级护理医院收治的袭击受害者的医学法律问题。
Q4 Medicine Pub Date : 2022-03-01 DOI: 10.1177/19253621211065616
Maleesa Sawaneeth Jayasundara, Yalini Thivaharan, Thanushan Muthulingam, Nirmal Borukgama, Deshan L Kulathunga, Indira D G Kitulwatte

Introduction: Violence with physical assault is a common cause of morbidity and mortality prevalent but not limited to underdeveloped countries. The opinion of the forensic expert is often indispensable in such cases to determine the penalties. This study was planned to describe the pattern of presentation of the victims and evaluate the strengths and limitations in formulating a scientific medicolegal opinion based on the findings of the victim.

Methods: A retrospective descriptive study based on the case records of the victims of assault admitted to Colombo North Teaching Hospital, Ragama, Sri Lanka, was conducted for four years.

Results: Out of the 400 victims, the majority (72% n = 290) were males and of the age-group of 21 to 40 (n = 216). The reason for assault in the majority was sudden provocation (n = 99, 25%), followed by previous long-duration enmity (n = 89, 22%). The majority (83%) had isolated blunt force trauma, and the injuries were nongrievous (74%). Defense injuries were significantly associated with attempted defense (p = 0.000) and sharp force trauma (p = 0.002). The underlying reason for the assault was not significantly associated with the causative weapon (p = 0.228) or body region injured (p = 0.195).

Conclusions: Even though the presentation and the pattern of injures are definitely of value in formulating a scientific opinion, the study identified the limitations of the forensic experts, and the need for a holistic approach at the investigations was highlighted.

简介:暴力与身体攻击是发病率和死亡率普遍普遍的共同原因,但不限于不发达国家。在这类案件中,法医专家的意见往往是决定处罚必不可少的。计划进行这项研究是为了描述受害者的陈述模式,并评估在根据受害者的调查结果提出科学的医学法律意见方面的优势和局限性。方法:对斯里兰卡拉加马科伦坡北教学医院收治的性侵受害者的病例记录进行了为期四年的回顾性描述性研究。结果:在400名受害者中,大多数(72% n = 290)为男性,年龄在21至40岁之间(n = 216)。攻击的主要原因是突然挑衅(n = 99, 25%),其次是之前的长期敌意(n = 89, 22%)。大多数(83%)有孤立的钝器创伤,损伤是非致命性的(74%)。防卫伤与防卫未遂(p = 0.000)和锐器伤(p = 0.002)显著相关。攻击的潜在原因与致病武器(p = 0.228)或身体受伤区域(p = 0.195)没有显著相关性。结论:尽管损伤的呈现和模式在形成科学意见方面肯定是有价值的,但该研究确定了法医专家的局限性,并强调了在调查中采用整体方法的必要性。
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引用次数: 0
Massive Air Embolism Following Necrotizing Pancreatitis and COVID-19 Infection-The Role of Postmortem Computed Tomography. 坏死性胰腺炎和 COVID-19 感染后的大面积空气栓塞--尸检计算机断层扫描的作用。
Q4 Medicine Pub Date : 2022-03-01 Epub Date: 2022-02-02 DOI: 10.1177/19253621211073284
Inga Melvinsdottir, Nadia Solomon, Roxanne Wadia, Thiruvengadam Muniraj, Steffen Huber, Albert J Sinusas

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that caused the COVID-19 pandemic raised important questions about workplace exposures to the virus, including postmortem exposures. The complexity of COVID-19 disease and its numerous unanticipated complications made autopsy even more vital in determining the pathophysiology of the disease. Performing traditional autopsy, however, carries risk of exposure. The following report describes an unusual case in which a patient diagnosed with COVID-19 and necrotizing pancreatitis underwent postmortem computed tomography (PMCT) prior to limited traditional autopsy and was unexpectedly found via PMCT to have large and diffuse venous air emboli and a new peripancreatic hematoma. In this case, not only did PMCT play a crucial role in determining the cause of death but also it allowed for a limited autopsy, thereby reducing the exposure to SARS-CoV-2 and associated risk to the autopsy staff and pathologists.

导致 COVID-19 大流行的严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)提出了有关工作场所接触病毒(包括死后接触)的重要问题。COVID-19 疾病的复杂性及其众多意料之外的并发症使得尸体解剖在确定该疾病的病理生理学方面变得更加重要。然而,进行传统的尸检存在暴露风险。下面的报告描述了一个不寻常的病例:一名被诊断患有 COVID-19 和坏死性胰腺炎的患者在进行有限的传统尸检之前接受了死后计算机断层扫描(PMCT),结果意外地通过 PMCT 发现了大面积弥漫性静脉空气栓塞和新的胰腺周围血肿。在这个病例中,PMCT 不仅在确定死因方面发挥了关键作用,而且还允许进行有限的尸检,从而减少了接触 SARS-CoV-2 的机会,降低了尸检人员和病理学家的相关风险。
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引用次数: 0
Double Suicide Due to the Ingestion of Levamisole-Adulterated Cocaine: Case Report and Review of the Literature. 左旋咪唑掺假可卡因致双重自杀:病例报告及文献回顾。
Q4 Medicine Pub Date : 2022-03-01 DOI: 10.1177/19253621211065334
Serenella Serinelli, Luigi Bonaccorso, Carmelo Furnari, Lorenzo Gitto

Suicide is a major public health issue and the risk of attempting and committing suicide increases with age. We present the case of an elderly couple who decided to commit suicide together by self-poisoning using levamisole-adulterated cocaine. The choice of committing a double suicide, the method selected (self-poisoning), the drug self-administered (cocaine), and the route of administration (ingestion) are events rarely encountered in the forensic pathology practice, especially not in combination. In this article, we will review the literature regarding the frequency and features of these methods of suicide. An overview of the effects and mechanism of action of levamisole is also provided, highlighting the importance of including this substance and its metabolites in the routine toxicological analyses for cocaine deaths.

自杀是一个重大的公共卫生问题,企图和实施自杀的风险随着年龄的增长而增加。我们提出的情况下,一对老年夫妇谁决定自杀,通过自行中毒使用左旋咪唑掺假可卡因一起。双重自杀的选择、自杀方式的选择(自毒)、自用的药物(可卡因)和给药途径(摄入)是法医病理学实践中很少遇到的事件,尤其不会同时发生。在这篇文章中,我们将回顾有关这些自杀方法的频率和特征的文献。还概述了左旋咪唑的作用和作用机制,强调了将这种物质及其代谢物纳入可卡因死亡的常规毒理学分析的重要性。
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引用次数: 0
Firsthand Experience in Graduating Three Cohorts of Forensic Pathologists Trained With Competency by Design (CBD) Curriculum. 通过设计(CBD)课程训练的三批法医病理学家毕业的第一手经验。
Q4 Medicine Pub Date : 2021-12-01 Epub Date: 2021-11-30 DOI: 10.1177/19253621211063104
Jayantha C Herath

Introduction: The University of Toronto experienced graduating three cohorts of forensic pathologists trained with Competency by Design (CBD) curriculum. We achieved this as a result of multiyear development of Entrustable Professional Activities (EPAs), Required Training Experience (RTEs), and Specialty Competency Requirements (SCRs) by the Royal College of Physicians and Surgeons of Canada's Forensic Pathology Speciality Committee, the Ontario Forensic Pathology Service, and the University of Toronto.

Method: Our academic year is comprised of 13 blocks. We divided the 13-block period into 4 stages to map all the EPAs and RTEs. The first stage, Transition to Discipline, is 1 block, the second stage, Foundation of Discipline, consists of 3 blocks; the third stage, Core of Discipline, consists of 6 blocks, and the final fourth stage, Transition to Practice, consists of 3 blocks. Board-certified faculty members in Forensic Pathology with more than five years of experience supervised the trainees. We graduated 5 Canadian and 4 international trainees at the end of the third cycle of CBD-based training program.

Conclusion: Using the Royal College Speciality Committee blueprint, the University of Toronto started in 2016 planning the CBD curriculum in the forensic pathology training program. By the end of June 2021, we graduated nine trainees from our CBD-based Forensic Pathology training program. We are training the fourth cohort, and they will be graduating at the end of June 2022. This article aims to share our firsthand experiencing in CBD training in forensic pathology.

简介:多伦多大学经历了三批法医病理学家的毕业,他们接受了能力设计(CBD)课程的培训。这是加拿大皇家内科和外科医师学院法医病理学专业委员会、安大略省法医病理学服务中心和多伦多大学多年来制定可信赖的专业活动(EPAs)、所需培训经验(rte)和专业能力要求(SCRs)的结果。方法:我们的学年由13个模块组成。我们将13个时间段分为4个阶段来绘制所有的环境影响评价和rte。第一阶段“向纪律过渡”为1个模块,第二阶段“纪律基础”为3个模块;第三阶段,核心训练,由6个模块组成,最后的第四个阶段,过渡到实践,由3个模块组成。在法医病理学委员会认证的教员有超过五年的经验监督学员。在第三轮基于cbd的培训项目结束时,我们毕业了5名加拿大学员和4名国际学员。结论:根据皇家学院专业委员会的蓝图,多伦多大学于2016年开始在法医病理学培训项目中规划CBD课程。截至2021年6月底,我校以cbd为基础的法医病理学培训项目共有9名学员毕业。我们正在培训第四批学员,他们将于2022年6月底毕业。本文旨在分享我们在法医病理学中进行CBD培训的第一手经验。
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引用次数: 1
Bases of Forensic Pathology Expert Testimony With Emphasis on Iowa v Tyler. 以爱荷华诉泰勒案为重点的法医病理学专家证词基础。
Q4 Medicine Pub Date : 2021-12-01 Epub Date: 2021-12-07 DOI: 10.1177/19253621211060961
Victor W Weedn

Judicial scrutiny of the forensic sciences is increasing. This scrutiny targets the bases for expert opinions. Forensic pathologists must understand that when they express an opinion it must have an articulable underlying basis. Iowa v Tyler provides a cautionary tale where testimony from a forensic pathologist on the cause and manner of death based exclusively on police reports and audio and video recordings of police interviews of the suspect rather than on medical evidence were held to be inadmissible. Tyler has an odd and distinguishable set of facts, but has been widely cited as an example of problematic forensic pathology testimony.

对法医学的司法审查正在增加。这种审查的目标是专家意见的基础。法医病理学家必须明白,当他们表达意见时,它必须有一个清晰的基础。爱荷华诉泰勒案提供了一个警示性的故事,即法医病理学家仅根据警方报告和警方对嫌疑人面谈的录音和录像提供的关于死亡原因和方式的证词,而不是根据医学证据提供的证词,被认为是不可接受的。泰勒有一组奇怪的、可区分的事实,但被广泛引用为有问题的法医病理学证词的一个例子。
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引用次数: 1
The "Magnificent Seven Errors" in Forensic Autopsy Practice: The Italian Context. 法医尸检实践中的“七大错误”:意大利语境。
Q4 Medicine Pub Date : 2021-12-01 Epub Date: 2021-11-09 DOI: 10.1177/19253621211056191
Roberto Scendoni, Piergiorgio Fedeli, Nunzia Cannovo, Mariano Cingolani

According to the Italian legal system, forensic autopsies are performed by a medical doctor specialized in legal medicine, otherwise known as a medicolegal expert (MLE), who has a range of very complex responsibilities. Indeed, the quality of forensic autopsy activity is always questioned in courts of law; incorrect assessments are dangerous because they can jeopardize the validity of a criminal investigation and thus affect the outcome so that a real culprit may be acquitted or an innocent person convicted. Nonconformities also discredit the professionalism of the specialist who performs the autopsy. The work of a MLE implies a series of assignments and duties that should be given constant consideration, but when certain aspects of this activity are underestimated or overlooked, this can lead the expert to make mistakes with irreparable consequences for the judicial investigation. In this article, for the first time, we present a summary of seven known errors related to autopsy activity following death by unnatural causes, with the purpose of alerting MLEs who work under the Italian judicial system to the potential dangers of such errors. These relate to: oversights in autopsy technique, incorrect collection of photographic and video material, unauthorized attendance at the autopsy, missing/mistaken reporting at any stage of the forensic activity, failure to notify the party forensic consultant, using histological or toxicological nonaccredited laboratories for forensic activities, and lack of observance of the chain of custody.

根据意大利法律制度,法医尸检由专门从事法律医学的医生进行,也称为法医专家(MLE),他有一系列非常复杂的职责。的确,法庭上法医解剖活动的质量总是受到质疑;错误的评估是危险的,因为它可能危及刑事调查的有效性,从而影响结果,使真正的罪犯可能被无罪释放,或使无辜的人被定罪。不符合也使进行尸检的专家的专业精神受到怀疑。MLE的工作意味着一系列的任务和职责,这些任务和职责应该得到不断的考虑,但是当这项活动的某些方面被低估或忽视时,这可能导致专家犯错误,对司法调查造成不可弥补的后果。在本文中,我们首次总结了与非自然原因死亡后尸检活动有关的七个已知错误,目的是提醒在意大利司法系统下工作的mle注意此类错误的潜在危险。这些问题涉及:尸检技术上的疏忽,不正确收集照片和视频材料,未经授权出席尸检,在法医活动的任何阶段缺少/错误报告,未通知法医顾问,使用未经认可的组织学或毒理学实验室进行法医活动,以及缺乏对监管链的遵守。
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引用次数: 2
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Academic Forensic Pathology
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