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The Impact of a Summer Intervention Focused on Foundational Concepts of Number Sense for Early Learners 夏季干预对早期学习者数感基本概念的影响
Q2 Mathematics Pub Date : 2022-05-24 DOI: 10.1080/19477503.2022.2073120
Sandi Cooper, Ryann N. Shelton, R. Padgett, Brandy Crowley, K. Kerschen, Melissa P. Donham
ABSTRACT This longitudinal quantitative study determined the impact of a summer mathematics academy for early learners on their number sense and how their number sense compared to that of their peers who did not attend the academy. The Texas Early Mathematics Inventory – Progress Monitoring (TEMI-PM) was used to measure students’ number sense. Results revealed that (1) all participants showed growth in their understanding of Number Identification in their first year of attending the academy, (2) participants who attended for two consecutive years grew in multiple areas of early number sense, and (3) participants who attended for one year demonstrated a decreased gap when compared to peers. The evidence supports the benefits of a mathematics-focused summer intervention to develop number sense for early learners.
本纵向定量研究确定了夏季数学学院对早期学习者数字感的影响,以及他们的数字感与未参加该学院的同龄人的比较。采用德州早期数学量表-进度监测(TEMI-PM)来测量学生的数感。结果表明:(1)所有参与者在入学第一年对数字识别的理解都有所增长,(2)连续两年的参与者在多个领域的早期数字感都有所增长,(3)参加一年的参与者与同龄人相比差距缩小。有证据支持以数学为重点的夏季干预对早期学习者发展数字感的好处。
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引用次数: 0
Analysis of anti-apoptotic PVT1 oncogene and apoptosis-related proteins (p53, Bcl2, PD-1, and PD-L1) expression in thyroid carcinoma. 甲状腺癌中抗凋亡PVT1癌基因和凋亡相关蛋白(p53、Bcl2、PD-1和PD-L1)的表达分析。
IF 2.6 Q2 Mathematics Pub Date : 2022-05-01 Epub Date: 2022-04-07 DOI: 10.1002/jcla.24390
Afaf T Ibrahiem, Amin K Makhdoom, Khalid S Alanazi, Abdulaziz M Alanazi, Abdulaziz M Mukhlef, Saad H Elshafey, Eman A Toraih, Manal S Fawzy

Background: An aberrant expression of long non-coding RNA PVT1 has been associated with apoptosis in various cancer types. We aimed to explore the PVT1 and four apoptosis-related proteins (p53, Bcl2, and PD-1/PD-L1) signature in thyroid cancer (TC).

Methods: The PVT1 expression level was measured in 64 FFPE TC paired samples by real-time quantitative PCR. Overall and stratified analyses by different clinicopathological features were done. The apoptotic proteins were evaluated by immunohistochemistry staining.

Results: Overall analysis showed significant PVT1upregulation in TC tissues (p < 0.001). Similarly, subgroup analysis by BRAFV600E mutation showed consistent results. Lower expression of p53 was associated with mortality (p = 0.001). Bcl2 overexpression was associated with greater tumor size (p = 0.005). At the same time, HCV-positive cases were associated with repressed Bcl2 expression levels (54.3% in HCV-negative vs. 6.9% in HCV-positive cases, p = 0.011). PD-1 expression was associated with lymph node metastasis (p = 0.004). Enhanced PD-L1 expression in the tumor was associated with a higher tumor stage, lymphovascular invasion, and mortality risk. Kaplan-Meier curves for overall survival showed that low p53 and high PD-L1 expressions were associated with lower survival time. The p53-positive staining is associated with a 90% decreased mortality risk (HR = 0.10, 95%CI = 0.02-0.47, p = 0.001), while patients with high PD-L1 were five times more likely to die (HR = 4.74, 95%CI = 1.2-18.7, p = 0.027).

Conclusion: Our results confirm the upregulation of PVT1 in TC. The apoptosis-related proteins (p53, Bcl2, and PD-1/PD-L1) showed different prognostic utility in TC patients; in particular, low p53 and high PD-L1 expressions associated with low survival times. Further large-scale and mechanistic studies are warranted.

背景:长非编码 RNA PVT1 的异常表达与多种癌症类型中的细胞凋亡有关。我们旨在探索甲状腺癌(TC)中 PVT1 和四种凋亡相关蛋白(p53、Bcl2 和 PD-1/PD-L1)的特征:方法:通过实时定量 PCR 检测 64 份 FFPE TC 配对样本中 PVT1 的表达水平。根据不同的临床病理特征进行总体和分层分析。免疫组化染色评估了凋亡蛋白:结果:总体分析显示 TC 组织中 PVT1 上调明显(p V600E 突变显示了一致的结果)。p53 的低表达与死亡率相关(p = 0.001)。Bcl2 过表达与肿瘤体积增大有关(p = 0.005)。同时,HCV 阳性病例与 Bcl2 表达水平受抑制有关(HCV 阴性病例为 54.3%,HCV 阳性病例为 6.9%,p = 0.011)。PD-1的表达与淋巴结转移有关(p = 0.004)。肿瘤中 PD-L1 表达的增强与肿瘤分期、淋巴管侵犯和死亡风险的升高有关。总生存期的 Kaplan-Meier 曲线显示,p53 低表达和 PD-L1 高表达与较低的生存期有关。p53阳性染色与90%的死亡风险降低相关(HR = 0.10,95%CI = 0.02-0.47,p = 0.001),而PD-L1高表达患者的死亡风险是p53阳性患者的5倍(HR = 4.74,95%CI = 1.2-18.7,p = 0.027):我们的研究结果证实了PVT1在TC中的上调。凋亡相关蛋白(p53、Bcl2 和 PD-1/PD-L1)在 TC 患者中显示出不同的预后效用;特别是,低 p53 和高 PD-L1 表达与低生存时间相关。有必要进一步开展大规模的机理研究。
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引用次数: 0
Studying Coach-teacher Interactions during Co-taught Mathematics Lessons 在合作授课的数学课程中研究教练与老师的互动
Q2 Mathematics Pub Date : 2022-04-06 DOI: 10.1080/19477503.2022.2052664
E. Saclarides
ABSTRACT Although co-teaching has been identified as a potentially productive coaching activity, research has yet to explore the kinds of coach-teacher interactions that are achieved during episodes of co-teaching. This exploratory study examined the foci and depth of coach-teacher interactions (n = 243) across 10 co-taught mathematics lessons between three coach-teacher dyads in one elementary school. Building upon findings from a previous study that explored coach-teacher interactions amid modeled mathematics lessons, the current study identified seven types of coach-teacher co-teaching interactions. Specifically, five types of co-teaching coach-teacher interactions were similar to those identified in the previous modeling study: Building Relationships, Discussing Content and Pedagogy, Joint Teaching, Logistics, Performative Praise and Discipline. Furthermore, two unique coach-teacher interactions were identified specific to co-teaching: Negotiating Coach-teacher Roles, Noticing and Responding to Student Thinking. Additionally, the current study utilizes the conceptualization of depth of coach-teacher interactions that was developed in the previous modeling study and extends it to a new context involving co-teaching, and illustrates that coaches and teachers can have brief interactions in which their reasoning is made public during mathematics instruction. Implications for coaches and administrators, as well as researchers who wish to further this line of inquiry are discussed.
摘要尽管联合教学已被确定为一种潜在的富有成效的辅导活动,但研究尚未探索在联合教学过程中实现的教练-教师互动的类型。这项探索性研究调查了一所小学三对教练-教师之间10节数学课上教练-教师互动的焦点和深度(n=243)。基于之前一项研究的结果,该研究探讨了数学模型课中教练与教师的互动,目前的研究确定了七种类型的教练与教师共同教学互动。具体而言,五种类型的联合教学-教练-教师互动与之前的建模研究中确定的相似:建立关系、讨论内容和教学法、联合教学、后勤、表演性赞扬和纪律。此外,还发现了两种针对联合教学的独特的教练-教师互动:协商教练-教师角色、注意和回应学生思维。此外,本研究利用了先前建模研究中开发的教练-教师互动深度的概念化,并将其扩展到涉及共同教学的新环境中,并说明教练和教师可以在数学教学中进行简短的互动,在互动中公开他们的推理。讨论了对教练和管理人员以及希望进一步开展这一调查的研究人员的影响。
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引用次数: 2
An Examination of Pre-Service Mathematics Teachers’ Problem-Formulation Performances 职前数学教师问题形成能力的考察
Q2 Mathematics Pub Date : 2022-04-04 DOI: 10.1080/19477503.2022.2058841
Tuğrul Kar, Beyzanur Erkan
ABSTRACT In the present study, we investigated pre-service mathematics teachers’ problem-formulation performances, which is a kind of problem-posing, in terms of being related to the existing problems, mathematical validity, and strategy types. Thirty-eight participants responded to a paper-and-pencil test wherein they formulated mathematics problems in as many ways as possible. We analyzed the problems formulated in the paper-and-pencil test according to our theoretical framework of problem-formulation strategy types and determined whether they were task-related and mathematically appropriate. The results indicated that most of the formulated problems were task-related and mathematically appropriate. The pre-service mathematics teachers tended to use strategies that involved making changes to the surface features of existing problems rather than the structural features of existing problems. The pre-service mathematics teachers used the strategy of replacing the given and requested information and generalizing strategies the least among the structural strategies. We also found that their problem-formulation tendencies changed according to the problem type.
摘要在本研究中,我们从与现有问题、数学有效性和策略类型的关系方面,调查了职前数学教师的问题制定表现,这是一种问题提出。38名参与者参加了纸笔测验,他们用尽可能多的方式提出数学问题。我们根据问题制定策略类型的理论框架,分析了纸笔测试中制定的问题,并确定它们是否与任务相关且在数学上合适。结果表明,大多数公式化问题都与任务相关,并且在数学上是合适的。职前数学教师倾向于使用涉及改变现有问题的表面特征而不是现有问题的结构特征的策略。职前数学教师采用的策略是替换给定和要求的信息,在结构策略中概括策略最少。我们还发现,他们的问题表述倾向随着问题类型的不同而变化。
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引用次数: 0
Developing the Student Postsecondary Instructional Practices Survey in Mathematics for Measuring Student Experiences in Introductory Mathematics Courses 开展学生中学后数学教学实践调查,以衡量学生在数学入门课程中的体验
Q2 Mathematics Pub Date : 2022-04-01 DOI: 10.1080/19477503.2022.2060023
Molly Creagar, Nathan Wakefield, W. Smith, Naneh Apkarian, Matthew Voigt
ABSTRACT Active Learning is becoming a standard method of delivering instruction in mathematics courses across the country. Researchers, administrators, policy makers, and instructors all need access to valid means of measuring practices used in the classroom. Drawing on the Postsecondary Instructional Practices Survey, the Student Postsecondary Instructional Practices Survey in Mathematics (SPIPS-M) was developed to measure the undergraduate student perspective of active learning. Factor analysis from 10 institutions (N = 16,495 surveys) supports a 4-factor model with a plausible theoretical foundation connected to the four pillars of Inquiry-Based Mathematics Education, by measuring the degree to which students perceive 1) their own engagement with meaningful mathematics, 2) collaboration to process mathematical ideas, 3) participation and formation of community, and 4) contribution of their own ideas for immediate instructor feedback. The instrument provides a new mechanism for program evaluation and course formative feedback. Ultimately the SPIPS-M instrument will allow a better understanding of the nuances of student experiences in their mathematics courses.
摘要主动学习正在成为全国数学课程教学的一种标准方法。研究人员、管理人员、政策制定者和教师都需要获得有效的手段来衡量课堂上使用的实践。在中学后教学实践调查的基础上,制定了学生中学后数学教学实践调查(SPIPS-M),以衡量本科生积极学习的观点。来自10个机构的因素分析(N=16495项调查)支持一个4因素模型,该模型具有与基于探究的数学教育的四大支柱相关的合理理论基础,通过测量学生感知的程度:1)他们自己参与有意义的数学,2)合作处理数学思想,3)参与和形成社区,以及4)他们自己的想法对即时教练反馈的贡献。该工具为课程评估和课程形成性反馈提供了一种新的机制。最终,SPIPS-M工具将使学生更好地理解数学课程中学生体验的细微差别。
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引用次数: 1
Untangling Classroom Positionings: An Instrumental Case Unpacking Positioning Theory in Mathematics Education 探究课堂定位:数学教育定位理论的工具性案例
Q2 Mathematics Pub Date : 2022-02-25 DOI: 10.1080/19477503.2022.2038470
Daniel Edelen, Sarah B. Bush, Ashley Schmidt, Tandrea Fulton, Lybrya Kebreab, Treshonda Rutledge
ABSTRACT In this paper, we aim to untangle positioning theory (Davies & Harré, 1990) and its implications for the field of mathematics education research, considering both existing use and potential use. Specific theoretical assumptions of positions or positionings in the context of learning mathematics are outlined. In this paper, a classroom-based instrumental case study illuminates examples of how students are positioned within their mathematical experiences as a means to understand some of the factors that affect how students come to exist within mathematical spaces and how classroom-based positionings impact students’ opportunities to engage in learning. Our goal is to present positioning theory as a potential tool for how our teaching practices impact students’ experiences in mathematical spaces. We present a moment-by-moment analysis, from an ethnographic perspective of the case, to clearly demonstrate how positioning theory may be utilized for both research and practice within mathematics education research. Implications for methodology and positioning theory through an ethnographic perspective are shared.
摘要在本文中,我们旨在理清定位理论(Davies&Harré,1990)及其对数学教育研究领域的影响,同时考虑现有用途和潜在用途。概述了在学习数学的背景下对立场或定位的具体理论假设。在本文中,一项基于课堂的工具性案例研究举例说明了学生在数学体验中的定位,以此来理解影响学生如何在数学空间中生存的一些因素,以及基于课堂的定位如何影响学生参与学习的机会。我们的目标是将定位理论作为一种潜在的工具来展示我们的教学实践如何影响学生在数学空间中的体验。我们从人种学的角度对案例进行了逐点分析,以清楚地展示定位理论如何在数学教育研究中用于研究和实践。从人种学的角度分享了对方法论和定位理论的启示。
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引用次数: 0
Mathematics Specialists as School-based Leaders: Adapting Responsibilities to Address Shifts in Teaching and Learning 作为学校领导的数学专家:适应责任以解决教与学的转变
Q2 Mathematics Pub Date : 2022-02-22 DOI: 10.1080/19477503.2022.2043664
C. Baker, M. Hjalmarson, F. Fennell
ABSTRACT Mathematics specialists support the teaching and learning of K-12 mathematics and attend to school-based responsibilities and needs. This study examined the shifts in responsibilities of mathematics specialists during the COVID −19 pandemic to better-understand their current and potential future influence on mathematics teaching. An online survey was administered nationally to reveal how school-based mathematics specialists adapted their responsibilities in response to the changing school conditions. Responses from school-based mathematics specialists were analyzed using a mixed methods approach to capture self-reported shifts in responsibilities, as well as challenges and opportunities. Findings indicate that the school-based mathematics specialists were able to rapidly reprioritize their responsibilities in response to both teachers’ professional learning and instructional needs. These findings illuminate the importance of mathematics specialists as school-based leaders who must continually navigate relationships and apply leadership knowledge and skills in novel ways to support shifts in mathematics teaching and learning.
数学专家支持K-12数学的教学和学习,并参与以学校为基础的责任和需求。本研究考察了2019冠状病毒病大流行期间数学专家职责的转变,以更好地了解他们目前和未来对数学教学的潜在影响。在全国范围内进行了一项在线调查,以揭示学校数学专家如何根据不断变化的学校条件调整他们的职责。来自学校的数学专家的回答使用混合方法进行分析,以捕捉自我报告的责任变化,以及挑战和机遇。研究结果表明,校本数学专家能够根据教师的专业学习和教学需求迅速重新调整其职责的优先顺序。这些发现阐明了数学专家作为学校领导者的重要性,他们必须不断地驾驭关系,并以新颖的方式应用领导知识和技能来支持数学教学和学习的转变。
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引用次数: 4
Researchers as Coaches: Developing Mathematics Teaching Capacity Using MEAs for STEM Integration 作为教练的研究人员:利用MEA培养STEM整合的数学教学能力
Q2 Mathematics Pub Date : 2022-01-02 DOI: 10.1080/19477503.2021.2023966
C. Baker, Terrie M. Galanti, T. Kraft, Nancy Holincheck, M. Hjalmarson, J. Nelson
ABSTRACT The purpose of this study was to explore how university researcher professional development design decisions built and sustained K-8 partnerships which foregrounded mathematics in integrated STEM via model-eliciting activities (MEAs). We applied a self-study methodology to facilitate a longitudinal examination of our practice in this multi-year project. We used the Decision-Making Protocol for Mathematics Coaching to understand our collaboration with division stakeholders as they worked toward integrating MEAs with district curriculum and pacing. Analysis of professional development artifacts, evidence of scholarship, and researcher memos revealed four recalibration points driven by district initiatives and leadership changes. Coaching with MEAs created opportunities for equitable student engagement and formative assessment. Implications for designing professional development that emphasizes explicit connections between the constraints of mathematics curriculum and the possibilities of teaching and learning through STEM integration are presented.
摘要本研究的目的是探索大学研究人员的专业发展设计决策是如何建立和维持K-8伙伴关系的,该伙伴关系通过模型启发活动(MEA)在综合STEM中预测数学。我们采用了自学方法,以便于对我们在这个多年项目中的实践进行纵向审查。我们使用数学辅导决策协议来了解我们与部门利益相关者的合作,因为他们致力于将MEA与地区课程和节奏相结合。对专业发展文物、学术证据和研究人员备忘录的分析揭示了由地区倡议和领导层变革驱动的四个重新校准点。MEA辅导为学生公平参与和形成性评估创造了机会。强调数学课程的约束与通过STEM整合进行教学的可能性之间的明确联系,这对设计专业发展具有重要意义。
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引用次数: 3
How Engagement with Mathematics in an Integrated STEM Lesson Evolved over Four Years 在四年的综合STEM课程中,学生对数学的参与度是如何变化的
Q2 Mathematics Pub Date : 2022-01-02 DOI: 10.1080/19477503.2021.2023965
Mollie H. Appelgate, Kari Jurgenson
ABSTRACT With student-centered, hands-on approaches to real-world problems, integrated STEM (science, technology, engineering, mathematics) curricula have the potential to engage students more authentically in multi-disciplinary learning and to learn mathematics more deeply. However, researchers have shown concern that the “M” is often a silent partner and have called for increasing mathematics’ visibility in STEM curricula. Taking into account this background, this paper investigated how teachers’ and students’ engagement with mathematics within a specific lesson in an integrated STEM unit evolved over four years in two elementary teachers’ classrooms and the factors the teachers pointed to that may explain their adaptations. Using classroom observations and teacher interviews, the results showed that the time engaged with the mathematics and the depth of engagement with the mathematics decreased over the four years. Five themes emerged that may explain their adaptations: 1) limited time, 2) the need to address required school academic standards in limited time, 3) materials and preparation, 4) the teachers’ comfort with the curriculum and, to a lesser extent, 5) their perceptions of their students’ abilities. These findings have implications for those that are writing, studying, or potentially using integrated STEM curricula in elementary schools.
综合STEM(科学、技术、工程、数学)课程以学生为中心,以实践方法解决现实世界的问题,有可能让学生更真实地参与多学科学习,并更深入地学习数学。然而,研究人员担心“M”往往是一个沉默的伙伴,并呼吁提高数学在STEM课程中的可见度。考虑到这一背景,本文调查了在两名小学教师的课堂上,教师和学生在综合STEM单元的特定课程中对数学的参与是如何在四年的时间里演变的,以及教师指出的可能解释他们适应的因素。通过课堂观察和教师访谈,结果表明,在四年中,参与数学的时间和参与数学的深度有所下降。出现了五个主题,可以解释他们的适应:1)有限的时间,2)需要在有限的时间内达到学校要求的学术标准,3)材料和准备,4)教师对课程的舒适度,以及在较小程度上,5)他们对学生能力的看法。这些发现对那些在小学写作、学习或可能使用综合STEM课程的人有影响。
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引用次数: 1
A Whole School Agreement: Professional Learning with a Focus on Environmental STEM 全校协议:以环境STEM为重点的专业学习
Q2 Mathematics Pub Date : 2022-01-02 DOI: 10.1080/19477503.2021.2023843
Stefanie D. Livers
ABSTRACT Science, technology, engineering, and mathematics (STEM) education is important to producing students prepared for problem solving, critical analysis, and collaborative approaches to address the needs of the 21st century. For meaningful and intentional STEM instruction to occur, teachers need support and professional development. This paper presents a case study of a year-long professional learning project connecting the school’s environmental science focus to improving mathematics instruction. A whole school agreement bounds this particular case. The school faculty initiated the project and included developing a mathematics trail to connect with their nature trail, garden, and an outdoor amphitheater. The quantitative and qualitative data reveal significant changes in mathematics practices and teachers’ beliefs about the teaching and learning of mathematics. Since this case study revealed that whole school professional development in STEM could improve the teaching and learning of mathematics, implications for practice and research are discussed.
科学、技术、工程和数学(STEM)教育对于培养学生解决问题、批判性分析和协作方法的能力,以满足21世纪的需求至关重要。为了实现有意义和有意的STEM教学,教师需要支持和专业发展。本文提出了一个为期一年的专业学习项目的案例研究,该项目将学校的环境科学重点与改善数学教学联系起来。整个学校的协议都限制了这种特殊情况。学校教师发起了这个项目,包括开发一条数学小径,将其与自然小径、花园和室外露天剧场连接起来。定量和定性数据揭示了数学实践和教师对数学教与学的信念的显著变化。由于本案例研究揭示了整个学校的STEM专业发展可以改善数学的教与学,因此讨论了实践和研究的意义。
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引用次数: 3
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Investigations in Mathematics Learning
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