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Radiomics for the radiologist: opportunities and challenges 放射科医生的放射组学:机遇与挑战
Pub Date : 2023-10-01 DOI: 10.23736/s2723-9284.23.00247-9
Michele AVANZO, Giovanni PIRRONE, Joseph STANCANELLO
Radiomics is a growing field where hundreds or thousands of quantitative features are extracted from a contoured region in a medical image in order to describe the image properties of a lesion or tissue. The radiomic features are then used for building an artificial intelligence-based model that can perform a diagnosis or characterization of tissues and organs. In this article we have defined the field of radiomics, its workflow and tools and describe some of the results achieved in studies applying radiomics. We also want to discuss its main limitations and strengths, in particular when compared with other artificial intelligence technique applied to imaging.
放射组学是一个不断发展的领域,从医学图像的轮廓区域提取数百或数千个定量特征,以描述病变或组织的图像特性。放射学特征随后被用于建立一个基于人工智能的模型,该模型可以对组织和器官进行诊断或表征。本文介绍了放射组学的研究领域、工作流程和工具,并介绍了一些应用放射组学的研究成果。我们还想讨论它的主要局限性和优势,特别是与应用于成像的其他人工智能技术相比。
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引用次数: 0
Application of artificial intelligence in chest radiology 人工智能在胸部放射学中的应用
Pub Date : 2023-10-01 DOI: 10.23736/s2723-9284.23.00256-0
Elisa BARATELLA, Pierluca MINELLI, Antonio SEGALOTTI, Maria A. COVA
Artificial intelligence (AI) has its earliest roots in ancient history and during the modern age the assumption that a human process could be mechanized was furtherly developed by Western philosophers. The term was coined for the first time in 1956, and in 1976 CASNET - a causal-associational network - was introduced in clinical practice as one of the very first prototypes of AI applied to medicine. The technological progress in the last three decades brought new interest and a significant development in the Artificial Intelligence field, which currently includes computational algorithms that can perform tasks once considered exclusive to human intelligence. Nowadays, there are several methods of Artificial Intelligence, above all machine learning - in which a training stage is needed by the algorithm to recognize specific features - and deep learning - in which algorithms form artificial neural networks in order to simulate the performances of neural networks of the human brain. There is currently an increasing application of AI in radiology and chest imaging is crucially involved in this topic: the aim of this narrative review is thus to describe all the possible applications of different methods of AI in thoracic radiology, regarding diagnostic imaging as well as interventional procedures.
人工智能(AI)最早起源于古代历史,在现代,西方哲学家进一步发展了人类过程可以机械化的假设。这个词在1956年首次被创造出来,1976年CASNET——一个因果关联网络——作为人工智能应用于医学的第一个原型之一被引入临床实践。过去三十年的技术进步给人工智能领域带来了新的兴趣和重大发展,目前包括可以执行曾经被认为是人类智能所独有的任务的计算算法。如今,人工智能有几种方法,首先是机器学习——算法需要一个训练阶段来识别特定的特征——以及深度学习——算法形成人工神经网络,以模拟人类大脑神经网络的性能。目前,人工智能在放射学中的应用越来越多,胸部成像在这一主题中至关重要:因此,本文的叙述性综述的目的是描述人工智能在胸部放射学中不同方法的所有可能应用,包括诊断成像和介入手术。
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引用次数: 0
Tools for quantitative radiology: natural and artificial intelligence together 定量放射学的工具:自然和人工智能的结合
Pub Date : 2023-10-01 DOI: 10.23736/s2723-9284.23.00249-9
Stefania MONTEMEZZI, Carlo CAVEDON
Artificial intelligence (AI) is a fast-moving technology that enables machines to perform tasks that could previously be done only by humans. The current debate is now whether machines will outperform humans, and therefore substitute them in critical tasks. In this paper, an attempt will be made to identify the most used AI techniques in diagnostic imaging, providing examples and identifying potential pitfalls.
人工智能(AI)是一项快速发展的技术,它使机器能够执行以前只能由人类完成的任务。目前的争论是,机器是否会超越人类,从而在关键任务中取代人类。在本文中,将尝试确定诊断成像中最常用的人工智能技术,提供示例并识别潜在的陷阱。
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引用次数: 0
Artificial intelligence in neuroradiology: brain CT perfusion imaging for acute ischemic stroke management 神经放射学中的人工智能:脑CT灌注成像在急性缺血性脑卒中管理中的应用
Pub Date : 2023-10-01 DOI: 10.23736/s2723-9284.23.00244-9
Umberto ROZZANIGO, Giulia CASAGRANDA, Marianna MOCHEN, Mauro FERRARI
Recent International and National Guidelines for management of Acute Ischemic Stroke recommend the use of automated perfusion software that calculates core/penumbra maps to support clinical decision-making. Artificial intelligence (AI) algorithms requires human expertise for the interpretation and real-life implementation, challenging the Radiologist to be responsible for the performance of this new diagnostic AI-based tool. We illustrate our experience introducing an automated computed tomography brain-perfusion software in the critical setting of the Emergency Radiology of a hub hospital, showing advantages and limitations of the currently available AI technology.
最近的国际和国家急性缺血性卒中管理指南建议使用自动灌注软件来计算核心/半暗带图,以支持临床决策。人工智能(AI)算法需要人类的专业知识来解释和现实生活中的实施,这对放射科医生负责这种基于人工智能的新型诊断工具的性能提出了挑战。我们阐述了我们在中心医院急诊放射科的关键环境中引入自动计算机断层扫描脑灌注软件的经验,展示了目前可用的人工智能技术的优势和局限性。
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引用次数: 0
Clinical applications of radiomics and artificial intelligence: prognostic stratification and response to treatment 放射组学和人工智能的临床应用:预后分层和治疗反应
Pub Date : 2023-10-01 DOI: 10.23736/s2723-9284.23.00245-9
Riccardo DE ROBERTIS, Flavio SPOTO, Francesca PASQUAZZO, Mirko D’ONOFRIO
The evaluation of treatment response and the noninvasive prognostic stratification of cancer patients are the most interesting and ambitious applications of radiomics and artificial intelligence, with potentially relevant clinical implications. Several studies reported promising results at this regard, even though their scientific quality is low and large-scale validation of the results is necessary. The purpose of this paper was to review systematic reviews and meta-analyses regarding the use of radiomics and artificial intelligence for prognostic stratification and evaluation of treatment response in cancer patients.
治疗反应的评估和癌症患者的无创预后分层是放射组学和人工智能最有趣和雄心勃勃的应用,具有潜在的相关临床意义。一些研究报告了在这方面有希望的结果,尽管它们的科学质量较低,并且需要对结果进行大规模验证。本文的目的是回顾有关放射组学和人工智能在癌症患者预后分层和治疗反应评估中的应用的系统综述和荟萃分析。
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引用次数: 0
Radiomics, radiogenomics and artificial intelligence in the study of liver and pancreatic tumors 放射组学、放射基因组学和人工智能在肝脏和胰腺肿瘤研究中的应用
Pub Date : 2023-10-01 DOI: 10.23736/s2723-9284.23.00254-0
Vittoria ROSSI, Riccardo DE ROBERTIS, Luisa TOMAIUOLO, Luca GERACI, Mirko D’ONOFRIO
Two branches on which precision medicine is based are radiomics and genomics, in particular the latter analyzes the different molecules. The study of the molecules is the basis of the response to treatment and therefore of the choice of the different therapeutic strategies. Currently, radiomic data are typically not incorporated as part of this data stream; however, this is changing with the adoption of structured radiology reporting. The challenge going forward will be to capture radiomic data as part of the structured report. Based on multiple studies about liver and pancreas neoplasms it is clearly visible what radiomics has brought in terms of preoperative prognostic factors related to survival and prognostic stratification, based on degree of aggressiveness of the lesion, as well as the evaluation of factors associated with presence of metastases or presence of vascular microinvasion. Several studies broadly describe genomic approaches to solve different problems in the context of liver and pancreatic imaging. In particular segmentation, quantification, characterization and improvement of image quality. Artificial intelligence will not be able to replace man, who covers a fundamental role; for example, the radiologist’s experience in manual tumor segmentation. Surely the prospect is to bring help in terms of time consumption.
精准医学的两个分支是放射组学和基因组学,特别是后者分析不同的分子。分子的研究是治疗反应的基础,因此也是选择不同治疗策略的基础。目前,放射性数据通常不作为该数据流的一部分;然而,随着结构化放射学报告的采用,这种情况正在改变。未来的挑战将是捕获放射性数据作为结构化报告的一部分。基于对肝脏和胰腺肿瘤的多项研究,可以清楚地看到放射组学在术前预后因素方面带来了什么,这些预后因素与生存和预后分层有关,基于病变的侵袭程度,以及与转移或血管微侵犯存在相关的因素的评估。一些研究广泛地描述了基因组方法来解决肝脏和胰腺成像中的不同问题。特别是分割,量化,表征和提高图像质量。人工智能将无法取代人类,人类扮演着基础性的角色;例如,放射科医生在手工肿瘤分割方面的经验。当然,前景是在时间消耗方面带来帮助。
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引用次数: 0
Machine learning and big data in precision medicine: what is the role of the Radiologist? 精准医疗中的机器学习和大数据:放射科医生的角色是什么?
Pub Date : 2023-10-01 DOI: 10.23736/s2723-9284.23.00252-0
Giovanni MORANA
With the advent of artificial intelligence (AI) in the field of radiology, a new perspective opens up in terms of diagnosis and management of patients. There is a need to review the way radiologists work so as to rebuild the doctor-patient relationship that has been sidelined over the years to increase our productivity. It is precisely the improvement in productivity that will be made possible by AI that will be able to free the radiology physician from time-consuming activities that add little to the diagnostic value of our work; this “gift of time” will have to be used to have a direct relationship with the patient, who can be followed up directly by the radiology physician, and not just sent by other physicians. This will be all the more necessary since with the new methods of image analysis (deep learning, texture analysis) the radiologist physician will not only have the task of diagnosing a lesion as accurately as possible, but also of indicating its evolution and progression, what makes indispensable a new pact with the patient, who will have to not only “accept” the diagnosis of an existing lesion but, above all, will have to trust the prognosis of that lesion, a trust based on an immaterial datum (the advanced image analysis) but which weighs like a boulder on the psyche of the patient. Only a relationship of great trust with his new physician, the radiologist, can make him follow our directions.
随着人工智能(AI)在放射学领域的出现,为患者的诊断和管理开辟了新的视角。有必要重新审视放射科医生的工作方式,以便重建多年来被搁置的医患关系,以提高我们的工作效率。人工智能将使生产力的提高成为可能,它将使放射科医生从耗时的活动中解放出来,这些活动对我们的工作的诊断价值几乎没有贡献;这种“时间的礼物”必须用来与病人建立直接的关系,病人可以由放射科医生直接随访,而不仅仅是由其他医生发送。这将是更加必要的,因为有了新的图像分析方法(深度学习,纹理分析),放射科医生不仅要尽可能准确地诊断病变,而且要表明其演变和进展,这使得与患者达成新的协议变得必不可少,患者不仅要“接受”现有病变的诊断,而且最重要的是,必须相信病变的预后。这是一种基于非物质数据(高级图像分析)的信任,但对患者的精神来说,它就像一块巨石。只有与他的新医生——放射科医生建立起高度信任的关系,才能使他听从我们的指示。
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引用次数: 0
Clinical applications of artificial intelligence in Radiology: prostate magnetic resonance imaging 人工智能在放射学中的临床应用:前列腺磁共振成像
Pub Date : 2023-10-01 DOI: 10.23736/s2723-9284.23.00255-0
Lorenzo CERESER, Leonardo MONTERUBBIANO, Valeria PERUZZI, Chiara ZUIANI, Rossano GIROMETTI
This review provides an overview of how artificial intelligence (AI) can assist radiologists in evaluating prostate magnetic resonance imaging (MRI). Main tasks include image quality assessment, gland outlining, lesion detection and classification, lesion delineation, and structured reporting. Although the implementation of AI-based systems is still in its early stages, they have demonstrated promising results in improving the accuracy and efficiency of prostate MRI and reducing variability in diagnostic performance. Specifically, AI-based tools have proven effective in image quality evaluation, gland segmentation, and lesion detection and classification. However, improvements are still necessary, particularly for lesion delineation and automatic structured reporting. Indeed, AI-assisted lesion delineation requires larger, uniformly labeled datasets, and automatic structured reporting requires higher-quality linguistic expression generation. Taken as a whole, while AI-based models hold significant potential to support radiologists in various prostate MRI-related tasks, validation through human-driven clinical trials is required before implementing them in clinical practice. High-quality research is warranted to demonstrate the added value of AI compared to radiologists alone to bridge the gap between the current role of supporting tool and the futuristic role of decision-making tool.
本文综述了人工智能(AI)如何协助放射科医生评估前列腺磁共振成像(MRI)。主要任务包括图像质量评估,腺体轮廓,病变检测和分类,病变描绘和结构化报告。尽管基于人工智能的系统的实施仍处于早期阶段,但它们在提高前列腺MRI的准确性和效率以及减少诊断性能的可变性方面已经显示出有希望的结果。具体来说,基于人工智能的工具在图像质量评估、腺体分割、病变检测和分类方面已经被证明是有效的。然而,改进仍然是必要的,特别是在病变描述和自动结构化报告方面。事实上,人工智能辅助的病变描绘需要更大、统一标记的数据集,而自动结构化报告需要更高质量的语言表达生成。总体而言,尽管基于人工智能的模型在支持放射科医生完成各种前列腺mri相关任务方面具有巨大的潜力,但在将其应用于临床实践之前,需要通过人类驱动的临床试验进行验证。与放射科医生相比,有必要进行高质量的研究,以证明人工智能的附加价值,弥合当前辅助工具的作用与未来决策工具的作用之间的差距。
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引用次数: 0
Lights and shadows of new models in the health-care research: artificial intelligence's role in crafting healthcare research papers 医疗保健研究新模型的光影:人工智能在撰写医疗保健研究论文中的作用
Pub Date : 2023-10-01 DOI: 10.23736/s2723-9284.23.00260-2
Mirco CLEVA, Lorenzo ZULIANI, Antonio PINTO, Ennio BRUSCHI, Mariachiara CIRILLO, Massimo VALENTINO
Generative artificial intelligence (AI) refers to algorithms that can be used to produce new content, such as text, regulations, images, videos and audio. The background of generative AI in the field of scientific research and publication has significantly shifted with the appearance of generative large language models, such as ChatGPT. ChatGPT represents an AI language model that can produce text close to human writing, making it appropriate for tasks such as summarizing literature and producing statistical studies. The release of ChatGPT has made a substantial influence in the academic world and it has become comprehensible that such technology will notably impact the method of working of researchers. Since its beginning, ChatGPT has been mentioned in several preprints and published articles with authorship credits. This has spawned a large discussion about the function of AI tools in published literature and whether they need to be recognized as authors among journal editors, academics and publishers. Specific guidelines will support the correct use of generative AI, which may be able of future activities such as experiment design and peer review, and facilitate the distribution of important scientific information through publications avoiding any types of scientific misconduct.
生成式人工智能(AI)是指可用于生成文本、法规、图像、视频和音频等新内容的算法。随着ChatGPT等生成式大型语言模型的出现,生成式人工智能在科研和出版领域的背景发生了显著变化。ChatGPT代表了一种人工智能语言模型,它可以生成接近人类写作的文本,使其适合于总结文献和生成统计研究等任务。ChatGPT的发布在学术界产生了重大影响,可以理解的是,这种技术将显著影响研究人员的工作方法。从一开始,ChatGPT就在一些预印本和已发表的文章中被提及。这引发了一场关于人工智能工具在已发表文献中的功能以及是否需要被期刊编辑、学者和出版商认可为作者的大讨论。具体的指导方针将支持正确使用生成式人工智能,这可能有助于未来的活动,如实验设计和同行评审,并通过出版物促进重要科学信息的分发,避免任何类型的科学不端行为。
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引用次数: 0
Artificial intelligence clinical applications in breast diagnostic imaging 人工智能在乳腺诊断成像中的临床应用
Pub Date : 2023-10-01 DOI: 10.23736/s2723-9284.23.00246-9
Calogero ZARCARO, Paola CLAUSER
Breast cancer is the most diagnosed cancer in women worldwide, causing significant morbidity and mortality. Imaging techniques play a pivotal role in the early detection of breast cancer; digital mammography (DM) and digital breast tomosynthesis are commonly used for screening average-risk women, while magnetic resonance imaging is employed for high-risk women. Although several progresses have been made in early diagnosis, the number of breast cancer-related deaths remains high, especially among younger women and those diagnosed at advanced stages. To address this problem, new tools are needed that can enable personalized screening or new early diagnosis strategies. Artificial intelligence (AI)-base techniques can assist radiographers and radiologists in various aspects of breast cancer management, including image quality optimization, breast density evaluation, risk assessment and lesion characterization. The level of maturity of the AI technologies currently available in breast imaging is variable. Computer-aided detection (CADe) and computer-aided diagnosis (CADx) were the first AI models introduced to aid radiologists in interpreting DM; CADe marked suspicious areas, while CADx assisted in characterizing findings. However, large-scale studies revealed limited utility and potential negative impacts on mammography interpretation. Conventional CAD systems suffered from low specificity and frequent false positives, failing to address human image perception limitations. The new generation of AI algorithms aims to overcome these limitations and assist radiologists in identifying hidden lesions. This review provides an overview of the current contributions of AI in breast cancer diagnosis, focusing on achieved results, potential objectives, and limitations in clinical practice application.
乳腺癌是全世界妇女中诊断最多的癌症,发病率和死亡率都很高。成像技术在乳腺癌的早期检测中起着关键作用;数字乳房x线照相术(DM)和数字乳房断层合成术通常用于筛查平均风险的女性,而磁共振成像则用于筛查高风险的女性。尽管在早期诊断方面取得了一些进展,但与乳腺癌有关的死亡人数仍然很高,特别是在年轻妇女和晚期诊断的妇女中。为了解决这个问题,需要新的工具来实现个性化筛查或新的早期诊断策略。基于人工智能(AI)的技术可以帮助放射技师和放射科医生在乳腺癌管理的各个方面,包括图像质量优化、乳房密度评估、风险评估和病变表征。目前在乳腺成像中可用的人工智能技术的成熟程度是可变的。计算机辅助检测(CADe)和计算机辅助诊断(CADx)是第一批用于帮助放射科医生解释糖尿病的人工智能模型;CADe标记可疑区域,而CADx协助表征发现。然而,大规模的研究显示,有限的效用和潜在的负面影响乳房x线摄影解释。传统的CAD系统遭受低特异性和频繁的误报,未能解决人类图像感知的局限性。新一代人工智能算法旨在克服这些限制,帮助放射科医生识别隐藏的病变。本文综述了目前人工智能在乳腺癌诊断中的贡献,重点介绍了已取得的结果、潜在目标和临床应用中的局限性。
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引用次数: 0
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Journal of Radiological Review
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