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Perioperative Treatment of Neuropathic Pain (Nerve SPACE 2025) 神经性疼痛的围手术期治疗(neurospace 2025)
Q3 Medicine Pub Date : 2026-01-29 DOI: 10.1016/j.jhsg.2025.100936
Adam Mosa MD, MSc , Neill Y. Li MD , Alexander Chamessian MD, PhD , Lara W. Crock MD, PhD , Catherine M. Curtin MD , Allan Belzberg MD , Sarah Buday PhD , Bryan J. Loeffler MD , Christopher Janney , Mark A. Mahan MD , Amy M. Moore MD
Neuropathic pain following brachial plexus and peripheral nerve injury represents one of the most debilitating and least effectively treated sequelae of nerve trauma.

Where are we now?

Neuropathic pain affects a majority of patients with severe nerve injuries and is frequently more disabling than associated motor or sensory deficits. The current scientific understanding implicates maladaptive peripheral and central nervous system changes, including neuroma formation, nociceptor hyperexcitability, central sensitization, and cortical reorganization. Contemporary management relies on multimodal strategies incorporating rehabilitation, pharmacotherapy, psychological support, neuromodulation, and select surgical interventions; however, most patients experience only partial or temporary relief, underscoring the persistent gap between mechanistic insight and durable clinical benefit.

Where do we need to go?

There remains a critical need for more effective, durable, and patient-centered approaches to neuropathic pain. Improved stratification tools, including biologic, imaging, and electrophysiologic biomarkers, are required to guide personalized treatment selection. Existing preclinical models inadequately capture the psychosocial and functional dimensions of pain, limiting translational relevance. Future therapies must better integrate biological, technological, and psychosocial domains while prioritizing pain relief as an outcome equal in importance to motor and sensory recovery.

How do we get there?

Progress will depend on multidisciplinary collaboration that aligns surgical innovation, targeted pharmacologic therapies, neuromodulation technologies, and structured psychological support. One target for growth in the field will be establishing multicenter registries and consensus-built outcome measures, which will be essential to evaluate real-world effectiveness and inform best practices. Continued refinement of biologically rational surgical strategies, emerging neuromodulation platforms, and integrative rehabilitation tools offer a pathway toward care models that address both pain and function. Meaningful improvements in quality of life for patients with nerve injury–related neuropathic pain may be achieved.
臂丛神经和周围神经损伤后的神经性疼痛是神经创伤后最令人衰弱和治疗效果最差的后遗症之一。我们现在在哪里?神经性疼痛影响大多数严重神经损伤的患者,其致残性往往比相关的运动或感觉缺陷更严重。目前的科学理解暗示了周围和中枢神经系统的不适应变化,包括神经瘤的形成、伤害感受器的高兴奋性、中枢敏化和皮层重组。当代治疗依赖于多模式策略,包括康复、药物治疗、心理支持、神经调节和选择性手术干预;然而,大多数患者只经历部分或暂时的缓解,强调了机制洞察力和持久临床益处之间的持续差距。我们要去哪里?对于神经性疼痛,迫切需要更有效、持久和以患者为中心的治疗方法。需要改进分层工具,包括生物、成像和电生理生物标志物,来指导个性化治疗选择。现有的临床前模型不能充分捕捉疼痛的社会心理和功能维度,限制了翻译的相关性。未来的治疗必须更好地整合生物、技术和社会心理领域,同时优先考虑疼痛缓解作为运动和感觉恢复同等重要的结果。我们怎么去那里?进展将取决于多学科合作,包括外科创新、靶向药物治疗、神经调节技术和结构化心理支持。该领域增长的一个目标将是建立多中心登记和建立共识的结果措施,这对于评估现实世界的有效性和为最佳做法提供信息至关重要。生物理性手术策略的不断完善,新兴的神经调节平台和综合康复工具为解决疼痛和功能的护理模式提供了途径。对神经损伤相关神经性疼痛患者的生活质量有意义的改善。
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引用次数: 0
Reported Minimal Clinically Important Differences for Patient-Reported Outcome Measures in Hand and Upper-Extremity Surgery: A Systematic Review 手部和上肢手术中患者报告的结果测量的最小临床重要差异:一项系统综述
Q3 Medicine Pub Date : 2026-01-29 DOI: 10.1016/j.jhsg.2025.100942
Jenna L. Dvorsky MS , Michael R. Kann BE , Christopher Gonzalez BS , Andrew Gordon BS , James Kim BS , Angela Hardi MS , John Fowler MD

Purpose

In hand and upper-extremity surgery, there are many patient-reported outcome measures (PROMs) used to quantify symptom severity and track patient progress. However, there remains variability and uncertainty regarding the true or most appropriate minimal clinically important difference (MCID) values for each. This systematic review summarized the reported MCIDs for the most commonly used outcome instruments in hand and upper-extremity surgery.

Methods

The published literature was searched using strategies designed by a medical librarian for the concepts of MCID; the Boston Carpal Tunnel Questionnaire; the Disabilities of the Arm, Shoulder, and Hand Score (DASH); the Michigan Hand Outcomes Questionnaire; carpel tunnel syndrome; and other hand/upper limb disorders with related synonyms. These strategies were executed in Embase, Ovid-Medline All, CINAHL Plus, Scopus, and Web of Science from database inception. Studies retrieved from the database literature search were imported to Endnote. Any duplicate citations were identified and removed. The remaining citations were imported to Covidence screening software for further screening analysis.

Results

In total, 25 studies published from 1998 to 2025 were included in final data extraction and analysis. Among these, 9 (36.0%) reported the MCID value for BCTQ, 4 (16.0%) reported the MCID value for the MHQ and DASH, and 12 (48.0%) reported the MCID value for the Quick Disabilities of the Arm, Shoulder, and Hand.

Conclusions

This comprehensive systematic review summarized the reported MCIDs for the Boston Carpal Tunnel Questionnaire, DASH, Quick Disabilities of the Arm, Shoulder, and Hand, and Michigan Hand Questionnaire, all of which are commonly used hand and upper-extremity PROMs. Reported MCIDs for a given PROM can vary not only with the population or diagnosis of patients included but also with the methods used to calculate meaningful change in these patients.

Clinical relevance

This systematic review reports the MCIDs for common hand and upper-extremity outcome measures, providing surgeons with reference values to interpret patient-reported changes, while also demonstrating variability in MCID based on diagnosis and methodology. This can help distinguish meaningful improvement for different clinical and patient settings in addition to aid design of studies with clinically relevant end points in upper-extremity surgery.
在手部和上肢手术中,有许多患者报告的结果测量(PROMs)用于量化症状严重程度和跟踪患者进展。然而,每种方法的真实或最合适的最小临床重要差异(MCID)值仍然存在可变性和不确定性。本系统综述总结了已报道的用于手部和上肢手术的最常用预后器械的MCIDs。方法采用医学图书馆员针对MCID概念设计的策略检索已发表的文献;波士顿腕管问卷;臂、肩、手残疾评分(DASH);密歇根手部结果问卷;腕管综合征;以及其他有相关同义词的手部/上肢疾病。这些策略在Embase, Ovid-Medline All, CINAHL Plus, Scopus和Web of Science中从数据库建立开始执行。从数据库文献检索中检索到的研究被导入到Endnote。发现并删除任何重复引用。将剩余的引文输入到冠状病毒筛查软件中进行进一步的筛查分析。结果共纳入1998 - 2025年发表的25篇研究,纳入最终数据提取和分析。其中,9例(36.0%)报告了BCTQ的MCID值,4例(16.0%)报告了MHQ和DASH的MCID值,12例(48.0%)报告了手臂、肩部和手部的快速残疾的MCID值。结论本研究对波士顿腕管调查问卷、DASH、手臂、肩膀和手的快速残疾以及密歇根手调查问卷中报道的mcid进行了全面的系统综述,这些都是常用的手部和上肢PROMs。给定胎膜早破所报告的MCIDs不仅随患者的人群或诊断而变化,而且随用于计算这些患者有意义变化的方法而变化。本系统综述报告了常见手部和上肢预后指标的mccid,为外科医生解释患者报告的变化提供了参考价值,同时也证明了基于诊断和方法的MCID的可变性。这有助于区分不同临床和患者环境下的有意义的改善,并有助于设计具有上肢手术临床相关终点的研究。
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引用次数: 0
Ongoing Clinical Challenges in Nerve Surgery (Nerve SPACE 2025) 神经外科持续的临床挑战(Nerve SPACE 2025)
Q3 Medicine Pub Date : 2026-01-28 DOI: 10.1016/j.jhsg.2025.100938
Katherine M. Gerull MD , David M. Brogan MD, MSc , Harvey Chim MD , Bryan J. Loeffler MD , Megan M. Jack MD , Robert J. Spinner MD , Macyn M. Stonner OTD

Where are we?

There have been numerous advances over the last decade in peripheral nerve surgery and rehabilitation following nerve transfers. In particular, advances in nerve allografts, nerve wraps, peripheral nerve sheath tumor treatment, and bionic limb technology have expanded the therapeutic landscape for patients with nerve injuries, tumors, and limb loss. Rehabilitation strategies have improved significantly, largely through advances such as the Donor Activation Focused Rehabilitation Approach. Nerve allografts show promise for short digital nerve gaps, though outcomes for proximal injuries remain controversial. Nerve wraps and connectors are widely available, but their efficacy has been controversial, perhaps due to heterogeneity in materials and limited high-quality research studies. In peripheral nerve sheath tumors, molecular subtyping has improved classification, yet reliable preoperative distinction between benign and malignant tumors remains a challenge. Bionic limb reconstruction has been improved through advances in targeted reinnervation, osseointegration, and myoelectric control, although prosthetic abandonment, phantom limb pain, and high costs remain barriers.

Where do we need to go?

Future progress requires rigorous empirical evidence to define effective rehabilitation protocols, clarifying the role of allografts versus autografts and determining the clinical utility of nerve wraps and connectors. Improved diagnostic tools are necessary for accurate tumor characterization, and novel systemic therapies are needed for malignant tumors with poor survival outcomes. In bionic limb reconstruction, future advances should integrate intuitive prosthetic control, sensory feedback, and improve pain management while ensuring equitable access to these technologies.

How do we get there?

Achieving these goals will require multicenter, nonconflicted, randomized clinical trials; the development of standardized outcome measures; and investment in translational research across cellular biology, imaging, and device development. Collaborative interdisciplinary research is critical to developing evidence-based protocols and technologies. Together, these strategies can continue to accelerate our understanding of peripheral nerve injury, disease, and rehabilitation.
我们在哪里?在过去的十年中,周围神经手术和神经移植后的康复取得了许多进展。特别是同种异体神经移植、神经包裹、周围神经鞘肿瘤治疗和仿生肢体技术的进步,扩大了神经损伤、肿瘤和肢体丧失患者的治疗前景。康复战略有了显著改善,主要是通过诸如以捐赠者激活为重点的康复方法等进展。同种异体神经移植显示了短指神经间隙的希望,尽管近端损伤的结果仍然存在争议。神经包裹和连接物广泛使用,但它们的功效一直存在争议,可能是由于材料的异质性和有限的高质量研究。在周围神经鞘肿瘤中,分子分型改善了分类,但术前可靠的良恶性肿瘤区分仍然是一个挑战。仿生肢体重建在靶向神经再生、骨整合和肌电控制方面取得了进展,尽管放弃假肢、幻肢疼痛和高成本仍然是障碍。我们要去哪里?未来的进展需要严格的经验证据来定义有效的康复方案,明确同种异体移植物与自体移植物的作用,并确定神经包裹和连接物的临床应用。改进的诊断工具对于准确的肿瘤特征是必要的,对于生存预后差的恶性肿瘤需要新的全身治疗。在仿生肢体重建中,未来的发展应该整合直观的假肢控制、感觉反馈和改善疼痛管理,同时确保公平地获得这些技术。我们怎么去那里?实现这些目标需要多中心、无冲突、随机的临床试验;制定标准化的结果衡量标准;投资于细胞生物学、成像和设备开发的转化研究。协作性跨学科研究对于开发基于证据的协议和技术至关重要。总之,这些策略可以继续加速我们对周围神经损伤、疾病和康复的理解。
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引用次数: 0
Localizing Nerve Injury, Defining Injury Severity, and Estimating Prognosis (Nerve SPACE 2025) 定位神经损伤,确定损伤严重程度,并估计预后(神经空间2025)
Q3 Medicine Pub Date : 2026-01-28 DOI: 10.1016/j.jhsg.2025.100940
John Fowler MD , David Wright MD , David Cholok MD , Sandip Biswal MD , Summer Gibbs PhD , Sameer Shah MD , Tom Quick MD , Ek Tsoon Tan PhD , Ryckie Wade PhD , O. Kenny Nwawka MD , Jonathan Winograd MD
<div><h3>Background</h3><div>Localizing nerve injury, defining injury severity, and estimating prognosis are critical factors in surgical decision-making when indicating patients for operative intervention following traumatic nerve injury.</div></div><div><h3>Where are we now?</h3><div>Current methods for localizing nerve injury and determining severity of injury include physical examination, electrodiagnostic studies, imaging including ultrasound and magnetic resonance imaging, and surgical exploration. However, these methods remain suboptimal, especially in cases of segmental or multilevel injury as is often seen in blunt force trauma as well as in cases of partial (axonotmetic) injury. A period of observation is often required to determine if spontaneous recovery will occur. In neurotmetic injuries, it is challenging to accurately determine the zone of injury intraoperatively to ensure that reconstruction is performed using healthy, viable nerve. As a result of these shortcomings, it has been difficult to accurately and consistently classify nerve injury according to location and severity which has resulted in difficulty estimating the prognosis for many injuries.</div></div><div><h3>Where do we need to go?</h3><div>Better diagnostic methods are needed to be able to accurately determine the location of nerve injury to direct surgical intervention and determine prognosis, especially in blunt, ballistic, multilevel, or segmental injuries. Additionally, improved methods are needed to evaluate partial axonotmetic injuries in which the epineurium remains grossly intact on inspection intraoperatively, but with varying degrees of axonotmetic injury within the nerve. This includes a need for both noninvasive preoperative imaging and biomarkers as well as intraoperative modalities to more accurately determine the degree of intraneural damage and assist in preoperative indications and intraoperative decision-making. Improving these diagnostic modalities will allow classification of injuries by location and severity on a more consistent and accurate basis, leading to improved ability to estimate prognosis, surgical indications, and intraoperative decision-making.</div></div><div><h3>How do we get there?</h3><div>Emerging diagnostic modalities, including simultaneous positron emission tomography and magnetic resonance imaging, nerve-specific fluorescence imaging, quantitative ultrasound and magnetic resonance imaging, peripheral nerve diffusion tensor imaging, magnetic resonance neurography, polarization-sensitive optical coherence tomography, and serum biomarkers for peripheral nerve injury, offer promising advances that may help better localize and define injury severity in peripheral nerve injury. More research and funding are needed to better understand how best to apply each of these modalities for traumatic nerve injury, leading to broader adoption, more accurate classification and consistent reporting of data that can be linked to patient outcomes
背景:神经损伤的定位、损伤严重程度的界定和预后的评估是创伤性神经损伤患者手术干预的关键因素。我们现在在哪里?目前定位神经损伤和确定损伤严重程度的方法包括体格检查、电诊断研究、成像(包括超声和磁共振成像)和手术探查。然而,这些方法仍然不是最理想的,特别是在钝力创伤中经常出现的节段性或多节段性损伤以及部分(轴索)损伤的情况下。通常需要一段时间的观察来确定是否会自发恢复。在神经移植损伤中,术中准确确定损伤区域以确保使用健康、有活力的神经进行重建是一项挑战。由于这些缺点,很难准确和一致地根据位置和严重程度对神经损伤进行分类,从而导致难以估计许多损伤的预后。我们要去哪里?需要更好的诊断方法来准确地确定神经损伤的位置,以便直接进行手术干预,并确定预后,特别是在钝性、弹道性、多节段性损伤中。此外,需要改进的方法来评估部分轴压性损伤,其中术中检查时神经外膜大致完好,但神经内有不同程度的轴压性损伤。这包括需要无创术前成像和生物标志物以及术中模式,以更准确地确定神经内损伤的程度,并协助术前指征和术中决策。改进这些诊断方式将使损伤在更一致和准确的基础上根据位置和严重程度进行分类,从而提高估计预后、手术指征和术中决策的能力。我们怎么去那里?新兴的诊断方法,包括同步正电子发射断层扫描和磁共振成像、神经特异性荧光成像、定量超声和磁共振成像、周围神经弥散张量成像、磁共振神经成像、偏振敏感光学相干断层扫描和周围神经损伤的血清生物标志物,提供了有希望的进展,可能有助于更好地定位和确定周围神经损伤的严重程度。需要更多的研究和资金来更好地了解如何最好地应用这些创伤性神经损伤的模式,从而更广泛地采用,更准确的分类和一致的数据报告,这些数据可以与患者的结果联系起来,最终有助于提高我们估计神经损伤后预后的能力。
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引用次数: 0
Current Gaps and Future Directions in Brachial Plexus, Upper-Extremity and Lower-Extremity Nerve Injuries (Nerve SPACE 2025) 臂丛、上肢和下肢神经损伤的现状和未来方向(Nerve SPACE 2025)
Q3 Medicine Pub Date : 2026-01-27 DOI: 10.1016/j.jhsg.2025.100935
Ethan Blum MEng , David J. Wright MD , Yusha Katie Liu MD, PhD , Christopher J. Dy MD, MPH.

Background

Treatment of peripheral nerve injury remains one of the most challenging aspects of reconstructive surgery. Functional outcomes remain inconsistent, high-quality evidence is limited, and major knowledge gaps persist.

Where are we now?

When evaluating patients for peripheral nerve injury, the treating physician must ascertain several critical factors to help inform decision-making, including the timing, mechanism, localization, and severity of the injury. Current algorithms rely on history, physical examination, electrodiagnostic studies, imaging, and occasionally operative exploration to establish a diagnosis. The surgeon must decide if the injury will recover spontaneously or if further operative intervention is indicated to achieve the best possible functional outcome. Accurate prognostication remains challenging secondary to the difficulty grouping patients into homogenous cohorts based on patient and injury characteristics, as well as heterogenous outcome measures. Intraoperatively, determining both the severity and zone of injury remains challenging. Surgical treatment strategies include neurolysis, primary repair, nerve grafting, nerve transfer, or tendon transfers. Functional outcomes assessment is currently performed using Medical Research Council muscle grading, range of motion measures, and various sensory measures, which remain subjective with inconsistent intraobserver and interobserver reliability. Nerve-specific patient reported outcomes measures remain limited.

Where do we need to go?

Diagnostic improvements are needed to more quickly and accurately define injury severity and determine which patients will benefit from surgical intervention. Intraoperatively, accurate determination of both the zone of injury and the functional status of the proximal nerve is also needed. Reproducible outcome measures that can be easily adopted across multiple institutions are needed to facilitate high-quality evidence that can help guide treatment decisions.

How do we get there?

Multicenter collaborative efforts are needed to focus clinical research priorities using reproducible diagnostic criteria to accurately define injury severity, establish consistency in surgical techniques and treatment algorithms, and accurately and reproducibly measure outcomes. Further translational efforts in imaging, biomaterials, and basic science research are also needed. By aligning research priorities with patient-centered outcomes, the field can begin to close the gap between surgical innovation and functional recovery.
背景:周围神经损伤的治疗仍然是重建手术中最具挑战性的方面之一。功能结果仍然不一致,高质量的证据有限,主要的知识差距仍然存在。我们现在在哪里?在评估患者周围神经损伤时,治疗医师必须确定几个关键因素,包括损伤的时间、机制、部位和严重程度,以帮助做出决策。目前的算法依赖于病史、体格检查、电诊断研究、成像和偶尔的手术探查来建立诊断。外科医生必须决定损伤是否会自行恢复,或者是否需要进一步的手术干预以达到最佳的功能结局。准确的预后仍然具有挑战性,因为很难根据患者和损伤特征将患者分组为同质队列,以及异质性的结果测量。术中,确定损伤的严重程度和区域仍然具有挑战性。手术治疗策略包括神经松解术、初级修复、神经移植、神经转移或肌腱转移。功能结果评估目前使用医学研究委员会肌肉分级、运动范围测量和各种感觉测量进行,这些测量仍然是主观的,观察者内部和观察者之间的可靠性不一致。神经特异性患者报告的结果措施仍然有限。我们要去哪里?诊断需要改进,以便更快、更准确地确定损伤的严重程度,并确定哪些患者将从手术干预中受益。术中还需要准确确定损伤区域和近端神经的功能状态。需要在多个机构间容易采用可重复的结果测量,以促进高质量证据,帮助指导治疗决策。我们怎么去那里?需要多中心合作来集中临床研究的重点,使用可重复的诊断标准来准确定义损伤严重程度,建立手术技术和治疗算法的一致性,并准确和可重复地测量结果。在成像、生物材料和基础科学研究方面也需要进一步的转化努力。通过将研究重点与以患者为中心的结果结合起来,该领域可以开始缩小手术创新与功能恢复之间的差距。
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引用次数: 0
Impact on Families of Upper Extremity Surgical Treatment for Children with Cerebral Palsy 脑瘫患儿上肢手术治疗对家庭的影响
Q3 Medicine Pub Date : 2026-01-24 DOI: 10.1016/j.jhsg.2025.100943
Sarah Romans MD , Adam Mosa MD , Lindley B. Wall MD, MSc

Purpose

Upper-extremity surgery for children with cerebral palsy (CP) aims to address spasticity, improve function, and enhance quality of life. Although previous research has focused on functional outcomes, limited data exist regarding the broader impact of these surgeries on families. This study examines the psychosocial, functional, and familial impacts of upper-extremity surgery in CP patients, which in turn would to inform preoperative education and postoperative support strategies.

Methods

Parents/guardians of children with CP who underwent upper-extremity surgery at least 6 months prior were recruited. Participants completed the validated Impact on Family Scale survey and participated in semistructured interviews exploring family experiences. Thematic analysis of interview transcripts was performed, with intercoder reliability achieved through independent coding. Survey data were analyzed to identify common family impacts.

Results

Thirteen interviews were conducted (11 parents, two patients). Thematic analysis identified six overarching themes: (1) functional and mobility improvements, including range of motion; (2) independence in activities of daily living; (3) positive cosmetic impacts; (4) patient psychosocial outcomes, such as increased confidence and social engagement; (5) family-level psychosocial outcomes, including stress during recovery and the importance of external family support systems; and (6) interactions with the care team. Impact on Family Scale survey results had a mean score of 55.1 and revealed that psychosocial and financial burdens varied, with the highest agreement for statements emphasizing normalization of the child’s condition.

Conclusions

Upper-extremity surgery for CP has profound physical and psychosocial impacts on both patients and their families. Improvements in functional independence, confidence, and aesthetics were commonly observed; however, emotional challenges during recovery were notable. The findings underscore the importance of setting realistic expectations, providing robust preoperative education, and ensuring access to psychosocial support systems. Future studies should investigate longitudinal outcomes and interventions to better support families during the surgical journey.

Type of study/level of evidence

Therapeutic IV.
目的脑瘫(CP)患儿上肢手术旨在解决痉挛,改善功能,提高生活质量。虽然以前的研究主要集中在功能结果上,但关于这些手术对家庭的广泛影响的数据有限。本研究探讨了上肢手术对CP患者的社会心理、功能和家庭影响,进而为术前教育和术后支持策略提供信息。方法招募至少6个月前接受上肢手术的CP患儿的家长/监护人。参与者完成了对家庭规模的影响调查,并参加了半结构化访谈,探讨家庭经历。对访谈笔录进行专题分析,通过独立编码实现码间可靠性。对调查数据进行分析,以确定常见的家庭影响。结果共访谈13次(11名家长,2名患者)。专题分析确定了六个总体主题:(1)功能和流动性改善,包括活动范围;(2)日常生活活动独立;(3)积极的美容影响;(4)患者心理社会结果,如增强信心和社会参与;(5)家庭层面的社会心理结果,包括康复期间的压力和外部家庭支持系统的重要性;(6)与护理团队的互动。对家庭规模的影响调查结果的平均得分为55.1,并揭示了社会心理和经济负担各不相同,对强调儿童状况正常化的陈述的一致性最高。结论超肢手术治疗CP对患者及其家属的生理和心理都有深远的影响。在功能独立性、自信和美学方面的改善是很常见的;然而,恢复期间的情绪挑战是值得注意的。研究结果强调了设定切合实际的期望、提供强有力的术前教育和确保获得社会心理支持系统的重要性。未来的研究应调查纵向结果和干预措施,以更好地支持家庭在手术过程中。研究类型/证据水平治疗性IV。
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引用次数: 0
Challenges in Clinical Research for Nerve Injuries (Nerve SPACE 2025) 神经损伤临床研究的挑战(Nerve SPACE 2025)
Q3 Medicine Pub Date : 2026-01-24 DOI: 10.1016/j.jhsg.2025.100939
Eliana B. Saltzman MD , Daniel Y. Hong MD , Roger Cornwall MD , Heather L. Baltzer MD, MSc , Thomas J. Wilson MD , Jenny M. Dorich PhD, CHT , Caroline Miller , Avi M. Giladi MD, MS , Paige M. Fox MD, PhD
Because of the relative infancy of peripheral nerve injury research, there is a lack of standardization of nomenclature and language. The lack of consistency among researchers and publications leads to difficulties assessing outcomes and comparing across patients, surgeons, and interventions.

Where Are We Now?

Current efforts in nerve research are focused on determining appropriate-study outcomes and the validation of these for both physicians and patients to reflect the goals of care. Siloed efforts across multiple institutions and specialties limit progress.

Where Do We Need to Go?

Future efforts in peripheral nerve injury clinical research should focus on aligning multiple core outcome sets in a reproducible fashion across similar conditions while integrating the patient experience. As outcomes are being implemented, there is a need to measure them accurately using group consensus and technology to limit bias.

How Do We Get There?

Collaboration between experts through individual surgeons and societal efforts to align on a minimal core set of outcomes is paramount. Integration into the electronic medical record will increase the feasibility of surgeons to use these outcomes as both research and clinical tools.
由于周围神经损伤的研究还处于起步阶段,因此在命名和语言上缺乏标准化。研究人员和出版物之间缺乏一致性导致难以评估结果和比较患者、外科医生和干预措施。我们现在在哪里?目前神经研究的重点是确定适当的研究结果,并对医生和患者进行验证,以反映护理目标。跨多个机构和专业的孤立努力限制了进展。我们需要去哪里?未来的周围神经损伤临床研究应集中于在相似条件下以可重复的方式调整多个核心结果集,同时整合患者经验。随着成果的实施,有必要利用群体共识和技术来限制偏见,准确地衡量它们。我们如何到达那里?专家之间的合作,通过个体外科医生和社会的努力,在最小的核心结果集上保持一致是至关重要的。整合到电子病历将增加外科医生使用这些结果作为研究和临床工具的可行性。
{"title":"Challenges in Clinical Research for Nerve Injuries (Nerve SPACE 2025)","authors":"Eliana B. Saltzman MD ,&nbsp;Daniel Y. Hong MD ,&nbsp;Roger Cornwall MD ,&nbsp;Heather L. Baltzer MD, MSc ,&nbsp;Thomas J. Wilson MD ,&nbsp;Jenny M. Dorich PhD, CHT ,&nbsp;Caroline Miller ,&nbsp;Avi M. Giladi MD, MS ,&nbsp;Paige M. Fox MD, PhD","doi":"10.1016/j.jhsg.2025.100939","DOIUrl":"10.1016/j.jhsg.2025.100939","url":null,"abstract":"<div><div>Because of the relative infancy of peripheral nerve injury research, there is a lack of standardization of nomenclature and language. The lack of consistency among researchers and publications leads to difficulties assessing outcomes and comparing across patients, surgeons, and interventions.</div></div><div><h3>Where Are We Now?</h3><div>Current efforts in nerve research are focused on determining appropriate-study outcomes and the validation of these for both physicians and patients to reflect the goals of care. Siloed efforts across multiple institutions and specialties limit progress.</div></div><div><h3>Where Do We Need to Go?</h3><div>Future efforts in peripheral nerve injury clinical research should focus on aligning multiple core outcome sets in a reproducible fashion across similar conditions while integrating the patient experience. As outcomes are being implemented, there is a need to measure them accurately using group consensus and technology to limit bias.</div></div><div><h3>How Do We Get There?</h3><div>Collaboration between experts through individual surgeons and societal efforts to align on a minimal core set of outcomes is paramount. Integration into the electronic medical record will increase the feasibility of surgeons to use these outcomes as both research and clinical tools.</div></div>","PeriodicalId":36920,"journal":{"name":"Journal of Hand Surgery Global Online","volume":"8 2","pages":"Article 100939"},"PeriodicalIF":0.0,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146022675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Out-Of-Pocket Expenses of Carpal Tunnel Release 腕管松解术的自费费用
Q3 Medicine Pub Date : 2026-01-24 DOI: 10.1016/j.jhsg.2025.100846
Derrick W. Williams MD, MBA , Philip Blazar MD , Kyra A. Benavent BS , Laura Byrne BS , Brandon E. Earp MD , Dafang Zhang MD

Purpose

Out-of-pocket charges (OOPCs) are growing faster than the total cost of care. Carpal tunnel release (CTR) is performed in variable surgical settings under different anesthetic protocols. OOPC of CTR may impact patient choice and patient perception of the value of their insurance. The primary objective of this study was to identify factors associated with OOPC after CTR.

Methods

We retrospectively identified patients who underwent CTR between January 1, 2019, and November 4, 2022 by three hand surgeons at a tertiary referral center in the Northeast United States. The final cohort comprised 808 patients. OOPC was defined as surgical and anesthesia fees billed to the patient for CTR surgery following primary and secondary insurance payment. Multivariable logistic regression analysis was performed to identify explanatory variables independently associated with our response variables.

Results

The mean age of the final cohort was 61.7 years, with 66% women, 79% White, and 100% insured. The multivariable logistic regression analysis showed protective factors against OOPC after CTR included Hispanic ethnicity and diabetes mellitus. Risk factors for having OOPC included no secondary insurance, procedure in a minor procedure room, and out-of-state residence.

Conclusions

As overall health care costs balloon, patients are bearing more financial responsibility for care. Our results may aid surgeons in shared decision-making discussions about modifiable surgical choices such as surgical setting and anesthesia choice.
Type of study/level of evidence: Economic Analysis IV.
目的自付费用(OOPCs)的增长速度超过了医疗总成本。腕管释放术(CTR)在不同的手术环境下进行。CTR的OOPC可能会影响患者的选择和患者对其保险价值的看法。本研究的主要目的是确定与CTR后OOPC相关的因素。方法回顾性分析2019年1月1日至2022年11月4日期间在美国东北部三级转诊中心由三名手外科医生接受CTR的患者。最后一组包括808名患者。OOPC定义为在初级和二级保险支付后向患者收取的CTR手术的手术和麻醉费用。我们进行多变量逻辑回归分析,以确定与我们的响应变量独立相关的解释变量。结果最终队列的平均年龄为61.7岁,66%为女性,79%为白人,100%为参保者。多变量logistic回归分析显示,CTR后发生OOPC的保护因素包括西班牙裔和糖尿病。患OOPC的风险因素包括没有二级保险,在小手术室手术,居住在州外。结论随着整体医疗费用的膨胀,患者承担了更多的医疗经济责任。我们的结果可能有助于外科医生共同决策讨论可修改的手术选择,如手术环境和麻醉选择。研究类型/证据水平:经济分析
{"title":"Out-Of-Pocket Expenses of Carpal Tunnel Release","authors":"Derrick W. Williams MD, MBA ,&nbsp;Philip Blazar MD ,&nbsp;Kyra A. Benavent BS ,&nbsp;Laura Byrne BS ,&nbsp;Brandon E. Earp MD ,&nbsp;Dafang Zhang MD","doi":"10.1016/j.jhsg.2025.100846","DOIUrl":"10.1016/j.jhsg.2025.100846","url":null,"abstract":"<div><h3>Purpose</h3><div>Out-of-pocket charges (OOPCs) are growing faster than the total cost of care. Carpal tunnel release (CTR) is performed in variable surgical settings under different anesthetic protocols. OOPC of CTR may impact patient choice and patient perception of the value of their insurance. The primary objective of this study was to identify factors associated with OOPC after CTR.</div></div><div><h3>Methods</h3><div>We retrospectively identified patients who underwent CTR between January 1, 2019, and November 4, 2022 by three hand surgeons at a tertiary referral center in the Northeast United States. The final cohort comprised 808 patients. OOPC was defined as surgical and anesthesia fees billed to the patient for CTR surgery following primary and secondary insurance payment. Multivariable logistic regression analysis was performed to identify explanatory variables independently associated with our response variables.</div></div><div><h3>Results</h3><div>The mean age of the final cohort was 61.7 years, with 66% women, 79% White, and 100% insured. The multivariable logistic regression analysis showed protective factors against OOPC after CTR included Hispanic ethnicity and diabetes mellitus. Risk factors for having OOPC included no secondary insurance, procedure in a minor procedure room, and out-of-state residence.</div></div><div><h3>Conclusions</h3><div>As overall health care costs balloon, patients are bearing more financial responsibility for care. Our results may aid surgeons in shared decision-making discussions about modifiable surgical choices such as surgical setting and anesthesia choice.</div><div><em>Type of study/level of evidence</em>: Economic Analysis IV.</div></div>","PeriodicalId":36920,"journal":{"name":"Journal of Hand Surgery Global Online","volume":"8 2","pages":"Article 100846"},"PeriodicalIF":0.0,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perineural Lipoma of the Ulnar Nerve Within the Cubital Tunnel: A Brief Review of the Literature 肘管内尺神经周围神经脂肪瘤:文献综述
Q3 Medicine Pub Date : 2026-01-23 DOI: 10.1016/j.jhsg.2025.100889
J.J.E. Delahaije MSc , J. van Boxtel MSc , S.F.A. Raupp MSc , E.L.W.G. van Haren MSc
This study presents a case of a patient with a 6-month history of progressively worsening paresthesia, numbness, weakness, and shooting pain in the ulnar nerve distribution of the left hand. Ultrasound measurements showed an enlarged cross-sectional area of the ulnar nerve, confirming the diagnosis, and an isoechogenic and homogenous mass alongside the ulnar nerve. An open cubital tunnel release was performed for ulnar nerve decompression. Intraoperatively, a perineural lipoma was identified within the cubital tunnel and subsequently confirmed by histopathological analysis. Soft tissue lipomas rarely cause symptomatic compressive neuropathy. Although other space-occupying lesions within the cubital tunnel are well-documented in the literature, a perineural lipoma causing extrinsic ulnar nerve compression has not been previously reported. After surgery, shooting pain resolved, sensation normalized in digits four and five, and hand strength gradually improved. Therefore, we report the first case of a perineural lipoma extrinsically causing ulnar nerve compression in the cubital tunnel.
本研究报告一例患者有6个月进行性加重的感觉异常、麻木、无力和左手尺神经分布的射痛病史。超声测量显示尺神经横截面积增大,证实了诊断,尺神经旁有等回声均匀肿块。开放肘管松解术用于尺神经减压。术中,在肘管内发现了一个神经周围脂肪瘤,随后通过组织病理学分析证实。软组织脂肪瘤很少引起有症状的压迫性神经病变。虽然文献中有很多关于肘管内其他占位性病变的报道,但神经周围脂肪瘤引起的外在尺神经压迫尚未见报道。手术后,射痛消退,4、5指感觉恢复正常,手部力量逐渐改善。因此,我们报告第一例神经周围脂肪瘤引起肘管尺神经压迫。
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引用次数: 0
Personality and Perception: A Qualitative Investigation of Factors That Shape Mentorship Satisfaction Among Hand Surgery Fellows 人格与知觉:手外科医师师徒满意度影响因素的质性研究
Q3 Medicine Pub Date : 2026-01-22 DOI: 10.1016/j.jhsg.2025.100922
Colby Newson MD , Steven Kozusko MD , Ava Chappell MD , Kacy J. Peek MD , A. Bobby Chhabra MD , Brent R. DeGeorge Jr. MD, PhD

Purpose

Mentorship is critical to the professional and personal development of surgical trainees, influencing clinical competence and career advancement. Although mentorship during residency has been widely studied, little is known about mentorship experiences during hand surgery fellowship, a brief and high stakes training period requiring rapid relationship formation. This study explored mentorship experiences and satisfaction among hand surgery fellows and to assess how personality traits, demographics, and program factors influence mentorship quality.

Methods

A mixed-methods study was conducted across 10 US hand surgery fellowship programs with Institutional Review Board approval. Participants completed an online questionnaire assessing demographics, fellowship characteristics, mentorship satisfaction, and personality traits. Semistructured interviews were conducted, transcribed, and analyzed using inductive content analysis to identify common themes. Quantitative data were analyzed using descriptive statistics, Pearson correlations, and analysis of variance with significance set at P < .05.

Results

A total of 10 fellows from 10 programs participated. Fellows valued personal mentor attributes (eg, altruism, honesty, patience) over relational and professional qualities and rated shared demographics as least important. Mentorship satisfaction showed nonsignificant trends: higher satisfaction among fellows who rated themselves as more emotionally stable and lower satisfaction among those scoring higher in openness to experience. Program structure showed similar trends, with greater satisfaction reported by fellows with more mentors and fewer cofellows. Qualitative analysis identified seven themes: (1) ideal mentor qualities, (2) organic relationship building, (3) mutual investment and communication, (4) diverse mentor expertise, (5) demographics and representation, (6) sponsorship beyond mentorship, and (7) dealing with time and other challenges.

Conclusions

Hand surgery fellows reported overall positive mentorship experiences and emphasized personal qualities over demographic similarity. Although quantitative associations were limited by sample size, trends suggest that personality traits and program structure may influence mentorship satisfaction. Recognizing these dynamics may help fellowship directors identify trainees at risk for poor mentorship alignment and implement early, targeted support within the 1-year fellowship’s limited timeframe.

Type of study/level of evidence

Differential diagnosis/symptom prevalence study IV.
目的指导对外科培训生的专业和个人发展至关重要,影响临床能力和职业发展。尽管住院医师的师徒关系已经得到了广泛的研究,但对于手外科实习期间的师徒关系知之甚少,这是一个短暂而高风险的培训阶段,需要快速建立关系。本研究探讨手外科医师的师徒经历与满意度,并评估人格特质、人口统计学和项目因素对师徒质量的影响。方法经机构审查委员会批准,在10个美国手外科奖学金项目中进行了一项混合方法研究。参与者完成了一份在线问卷,评估人口统计、团契特征、师徒满意度和个性特征。半结构化访谈进行,转录和分析使用归纳内容分析,以确定共同的主题。定量数据分析采用描述性统计、Pearson相关性和方差分析,显著性设置为P <; 0.05。结果10个项目共10名研究员参与。研究人员更看重导师的个人品质(如利他主义、诚实、耐心),而不是人际关系和专业素质,并将共同的人口特征列为最不重要的。师徒满意度表现出不显著的趋势:那些认为自己情绪更稳定的人满意度更高,而那些认为自己经验开放性更高的人满意度更低。项目结构也显示出类似的趋势,导师越多,同事越少,学员的满意度越高。定性分析确定了七个主题:(1)理想的导师素质,(2)有机关系的建立,(3)相互投资和沟通,(4)多样化的导师专业知识,(5)人口统计和代表性,(6)超越导师的赞助,以及(7)处理时间和其他挑战。结论:外科和外科研究员报告了总体上积极的师徒经历,并强调个人素质高于人口统计学相似性。虽然数量关联受到样本量的限制,但趋势表明人格特质和项目结构可能会影响师徒满意度。认识到这些动态可能有助于奖学金主任识别有可能出现导师不一致的学员,并在1年奖学金有限的时间框架内尽早实施有针对性的支持。研究类型/证据水平鉴别诊断/症状患病率研究IV。
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引用次数: 0
期刊
Journal of Hand Surgery Global Online
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