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Impact on Families of Upper Extremity Surgical Treatment for Children with Cerebral Palsy 脑瘫患儿上肢手术治疗对家庭的影响
Q3 Medicine Pub Date : 2026-01-24 DOI: 10.1016/j.jhsg.2025.100943
Sarah Romans MD , Adam Mosa MD , Lindley B. Wall MD, MSc

Purpose

Upper-extremity surgery for children with cerebral palsy (CP) aims to address spasticity, improve function, and enhance quality of life. Although previous research has focused on functional outcomes, limited data exist regarding the broader impact of these surgeries on families. This study examines the psychosocial, functional, and familial impacts of upper-extremity surgery in CP patients, which in turn would to inform preoperative education and postoperative support strategies.

Methods

Parents/guardians of children with CP who underwent upper-extremity surgery at least 6 months prior were recruited. Participants completed the validated Impact on Family Scale survey and participated in semistructured interviews exploring family experiences. Thematic analysis of interview transcripts was performed, with intercoder reliability achieved through independent coding. Survey data were analyzed to identify common family impacts.

Results

Thirteen interviews were conducted (11 parents, two patients). Thematic analysis identified six overarching themes: (1) functional and mobility improvements, including range of motion; (2) independence in activities of daily living; (3) positive cosmetic impacts; (4) patient psychosocial outcomes, such as increased confidence and social engagement; (5) family-level psychosocial outcomes, including stress during recovery and the importance of external family support systems; and (6) interactions with the care team. Impact on Family Scale survey results had a mean score of 55.1 and revealed that psychosocial and financial burdens varied, with the highest agreement for statements emphasizing normalization of the child’s condition.

Conclusions

Upper-extremity surgery for CP has profound physical and psychosocial impacts on both patients and their families. Improvements in functional independence, confidence, and aesthetics were commonly observed; however, emotional challenges during recovery were notable. The findings underscore the importance of setting realistic expectations, providing robust preoperative education, and ensuring access to psychosocial support systems. Future studies should investigate longitudinal outcomes and interventions to better support families during the surgical journey.

Type of study/level of evidence

Therapeutic IV.
目的脑瘫(CP)患儿上肢手术旨在解决痉挛,改善功能,提高生活质量。虽然以前的研究主要集中在功能结果上,但关于这些手术对家庭的广泛影响的数据有限。本研究探讨了上肢手术对CP患者的社会心理、功能和家庭影响,进而为术前教育和术后支持策略提供信息。方法招募至少6个月前接受上肢手术的CP患儿的家长/监护人。参与者完成了对家庭规模的影响调查,并参加了半结构化访谈,探讨家庭经历。对访谈笔录进行专题分析,通过独立编码实现码间可靠性。对调查数据进行分析,以确定常见的家庭影响。结果共访谈13次(11名家长,2名患者)。专题分析确定了六个总体主题:(1)功能和流动性改善,包括活动范围;(2)日常生活活动独立;(3)积极的美容影响;(4)患者心理社会结果,如增强信心和社会参与;(5)家庭层面的社会心理结果,包括康复期间的压力和外部家庭支持系统的重要性;(6)与护理团队的互动。对家庭规模的影响调查结果的平均得分为55.1,并揭示了社会心理和经济负担各不相同,对强调儿童状况正常化的陈述的一致性最高。结论超肢手术治疗CP对患者及其家属的生理和心理都有深远的影响。在功能独立性、自信和美学方面的改善是很常见的;然而,恢复期间的情绪挑战是值得注意的。研究结果强调了设定切合实际的期望、提供强有力的术前教育和确保获得社会心理支持系统的重要性。未来的研究应调查纵向结果和干预措施,以更好地支持家庭在手术过程中。研究类型/证据水平治疗性IV。
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引用次数: 0
Challenges in Clinical Research for Nerve Injuries (Nerve SPACE 2025) 神经损伤临床研究的挑战(Nerve SPACE 2025)
Q3 Medicine Pub Date : 2026-01-24 DOI: 10.1016/j.jhsg.2025.100939
Eliana B. Saltzman MD , Daniel Y. Hong MD , Roger Cornwall MD , Heather L. Baltzer MD, MSc , Thomas J. Wilson MD , Jenny M. Dorich PhD, CHT , Caroline Miller , Avi M. Giladi MD, MS , Paige M. Fox MD, PhD
Because of the relative infancy of peripheral nerve injury research, there is a lack of standardization of nomenclature and language. The lack of consistency among researchers and publications leads to difficulties assessing outcomes and comparing across patients, surgeons, and interventions.

Where Are We Now?

Current efforts in nerve research are focused on determining appropriate-study outcomes and the validation of these for both physicians and patients to reflect the goals of care. Siloed efforts across multiple institutions and specialties limit progress.

Where Do We Need to Go?

Future efforts in peripheral nerve injury clinical research should focus on aligning multiple core outcome sets in a reproducible fashion across similar conditions while integrating the patient experience. As outcomes are being implemented, there is a need to measure them accurately using group consensus and technology to limit bias.

How Do We Get There?

Collaboration between experts through individual surgeons and societal efforts to align on a minimal core set of outcomes is paramount. Integration into the electronic medical record will increase the feasibility of surgeons to use these outcomes as both research and clinical tools.
由于周围神经损伤的研究还处于起步阶段,因此在命名和语言上缺乏标准化。研究人员和出版物之间缺乏一致性导致难以评估结果和比较患者、外科医生和干预措施。我们现在在哪里?目前神经研究的重点是确定适当的研究结果,并对医生和患者进行验证,以反映护理目标。跨多个机构和专业的孤立努力限制了进展。我们需要去哪里?未来的周围神经损伤临床研究应集中于在相似条件下以可重复的方式调整多个核心结果集,同时整合患者经验。随着成果的实施,有必要利用群体共识和技术来限制偏见,准确地衡量它们。我们如何到达那里?专家之间的合作,通过个体外科医生和社会的努力,在最小的核心结果集上保持一致是至关重要的。整合到电子病历将增加外科医生使用这些结果作为研究和临床工具的可行性。
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引用次数: 0
Out-Of-Pocket Expenses of Carpal Tunnel Release 腕管松解术的自费费用
Q3 Medicine Pub Date : 2026-01-24 DOI: 10.1016/j.jhsg.2025.100846
Derrick W. Williams MD, MBA , Philip Blazar MD , Kyra A. Benavent BS , Laura Byrne BS , Brandon E. Earp MD , Dafang Zhang MD

Purpose

Out-of-pocket charges (OOPCs) are growing faster than the total cost of care. Carpal tunnel release (CTR) is performed in variable surgical settings under different anesthetic protocols. OOPC of CTR may impact patient choice and patient perception of the value of their insurance. The primary objective of this study was to identify factors associated with OOPC after CTR.

Methods

We retrospectively identified patients who underwent CTR between January 1, 2019, and November 4, 2022 by three hand surgeons at a tertiary referral center in the Northeast United States. The final cohort comprised 808 patients. OOPC was defined as surgical and anesthesia fees billed to the patient for CTR surgery following primary and secondary insurance payment. Multivariable logistic regression analysis was performed to identify explanatory variables independently associated with our response variables.

Results

The mean age of the final cohort was 61.7 years, with 66% women, 79% White, and 100% insured. The multivariable logistic regression analysis showed protective factors against OOPC after CTR included Hispanic ethnicity and diabetes mellitus. Risk factors for having OOPC included no secondary insurance, procedure in a minor procedure room, and out-of-state residence.

Conclusions

As overall health care costs balloon, patients are bearing more financial responsibility for care. Our results may aid surgeons in shared decision-making discussions about modifiable surgical choices such as surgical setting and anesthesia choice.
Type of study/level of evidence: Economic Analysis IV.
目的自付费用(OOPCs)的增长速度超过了医疗总成本。腕管释放术(CTR)在不同的手术环境下进行。CTR的OOPC可能会影响患者的选择和患者对其保险价值的看法。本研究的主要目的是确定与CTR后OOPC相关的因素。方法回顾性分析2019年1月1日至2022年11月4日期间在美国东北部三级转诊中心由三名手外科医生接受CTR的患者。最后一组包括808名患者。OOPC定义为在初级和二级保险支付后向患者收取的CTR手术的手术和麻醉费用。我们进行多变量逻辑回归分析,以确定与我们的响应变量独立相关的解释变量。结果最终队列的平均年龄为61.7岁,66%为女性,79%为白人,100%为参保者。多变量logistic回归分析显示,CTR后发生OOPC的保护因素包括西班牙裔和糖尿病。患OOPC的风险因素包括没有二级保险,在小手术室手术,居住在州外。结论随着整体医疗费用的膨胀,患者承担了更多的医疗经济责任。我们的结果可能有助于外科医生共同决策讨论可修改的手术选择,如手术环境和麻醉选择。研究类型/证据水平:经济分析
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引用次数: 0
Perineural Lipoma of the Ulnar Nerve Within the Cubital Tunnel: A Brief Review of the Literature 肘管内尺神经周围神经脂肪瘤:文献综述
Q3 Medicine Pub Date : 2026-01-23 DOI: 10.1016/j.jhsg.2025.100889
J.J.E. Delahaije MSc , J. van Boxtel MSc , S.F.A. Raupp MSc , E.L.W.G. van Haren MSc
This study presents a case of a patient with a 6-month history of progressively worsening paresthesia, numbness, weakness, and shooting pain in the ulnar nerve distribution of the left hand. Ultrasound measurements showed an enlarged cross-sectional area of the ulnar nerve, confirming the diagnosis, and an isoechogenic and homogenous mass alongside the ulnar nerve. An open cubital tunnel release was performed for ulnar nerve decompression. Intraoperatively, a perineural lipoma was identified within the cubital tunnel and subsequently confirmed by histopathological analysis. Soft tissue lipomas rarely cause symptomatic compressive neuropathy. Although other space-occupying lesions within the cubital tunnel are well-documented in the literature, a perineural lipoma causing extrinsic ulnar nerve compression has not been previously reported. After surgery, shooting pain resolved, sensation normalized in digits four and five, and hand strength gradually improved. Therefore, we report the first case of a perineural lipoma extrinsically causing ulnar nerve compression in the cubital tunnel.
本研究报告一例患者有6个月进行性加重的感觉异常、麻木、无力和左手尺神经分布的射痛病史。超声测量显示尺神经横截面积增大,证实了诊断,尺神经旁有等回声均匀肿块。开放肘管松解术用于尺神经减压。术中,在肘管内发现了一个神经周围脂肪瘤,随后通过组织病理学分析证实。软组织脂肪瘤很少引起有症状的压迫性神经病变。虽然文献中有很多关于肘管内其他占位性病变的报道,但神经周围脂肪瘤引起的外在尺神经压迫尚未见报道。手术后,射痛消退,4、5指感觉恢复正常,手部力量逐渐改善。因此,我们报告第一例神经周围脂肪瘤引起肘管尺神经压迫。
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引用次数: 0
Personality and Perception: A Qualitative Investigation of Factors That Shape Mentorship Satisfaction Among Hand Surgery Fellows 人格与知觉:手外科医师师徒满意度影响因素的质性研究
Q3 Medicine Pub Date : 2026-01-22 DOI: 10.1016/j.jhsg.2025.100922
Colby Newson MD , Steven Kozusko MD , Ava Chappell MD , Kacy J. Peek MD , A. Bobby Chhabra MD , Brent R. DeGeorge Jr. MD, PhD

Purpose

Mentorship is critical to the professional and personal development of surgical trainees, influencing clinical competence and career advancement. Although mentorship during residency has been widely studied, little is known about mentorship experiences during hand surgery fellowship, a brief and high stakes training period requiring rapid relationship formation. This study explored mentorship experiences and satisfaction among hand surgery fellows and to assess how personality traits, demographics, and program factors influence mentorship quality.

Methods

A mixed-methods study was conducted across 10 US hand surgery fellowship programs with Institutional Review Board approval. Participants completed an online questionnaire assessing demographics, fellowship characteristics, mentorship satisfaction, and personality traits. Semistructured interviews were conducted, transcribed, and analyzed using inductive content analysis to identify common themes. Quantitative data were analyzed using descriptive statistics, Pearson correlations, and analysis of variance with significance set at P < .05.

Results

A total of 10 fellows from 10 programs participated. Fellows valued personal mentor attributes (eg, altruism, honesty, patience) over relational and professional qualities and rated shared demographics as least important. Mentorship satisfaction showed nonsignificant trends: higher satisfaction among fellows who rated themselves as more emotionally stable and lower satisfaction among those scoring higher in openness to experience. Program structure showed similar trends, with greater satisfaction reported by fellows with more mentors and fewer cofellows. Qualitative analysis identified seven themes: (1) ideal mentor qualities, (2) organic relationship building, (3) mutual investment and communication, (4) diverse mentor expertise, (5) demographics and representation, (6) sponsorship beyond mentorship, and (7) dealing with time and other challenges.

Conclusions

Hand surgery fellows reported overall positive mentorship experiences and emphasized personal qualities over demographic similarity. Although quantitative associations were limited by sample size, trends suggest that personality traits and program structure may influence mentorship satisfaction. Recognizing these dynamics may help fellowship directors identify trainees at risk for poor mentorship alignment and implement early, targeted support within the 1-year fellowship’s limited timeframe.

Type of study/level of evidence

Differential diagnosis/symptom prevalence study IV.
目的指导对外科培训生的专业和个人发展至关重要,影响临床能力和职业发展。尽管住院医师的师徒关系已经得到了广泛的研究,但对于手外科实习期间的师徒关系知之甚少,这是一个短暂而高风险的培训阶段,需要快速建立关系。本研究探讨手外科医师的师徒经历与满意度,并评估人格特质、人口统计学和项目因素对师徒质量的影响。方法经机构审查委员会批准,在10个美国手外科奖学金项目中进行了一项混合方法研究。参与者完成了一份在线问卷,评估人口统计、团契特征、师徒满意度和个性特征。半结构化访谈进行,转录和分析使用归纳内容分析,以确定共同的主题。定量数据分析采用描述性统计、Pearson相关性和方差分析,显著性设置为P <; 0.05。结果10个项目共10名研究员参与。研究人员更看重导师的个人品质(如利他主义、诚实、耐心),而不是人际关系和专业素质,并将共同的人口特征列为最不重要的。师徒满意度表现出不显著的趋势:那些认为自己情绪更稳定的人满意度更高,而那些认为自己经验开放性更高的人满意度更低。项目结构也显示出类似的趋势,导师越多,同事越少,学员的满意度越高。定性分析确定了七个主题:(1)理想的导师素质,(2)有机关系的建立,(3)相互投资和沟通,(4)多样化的导师专业知识,(5)人口统计和代表性,(6)超越导师的赞助,以及(7)处理时间和其他挑战。结论:外科和外科研究员报告了总体上积极的师徒经历,并强调个人素质高于人口统计学相似性。虽然数量关联受到样本量的限制,但趋势表明人格特质和项目结构可能会影响师徒满意度。认识到这些动态可能有助于奖学金主任识别有可能出现导师不一致的学员,并在1年奖学金有限的时间框架内尽早实施有针对性的支持。研究类型/证据水平鉴别诊断/症状患病率研究IV。
{"title":"Personality and Perception: A Qualitative Investigation of Factors That Shape Mentorship Satisfaction Among Hand Surgery Fellows","authors":"Colby Newson MD ,&nbsp;Steven Kozusko MD ,&nbsp;Ava Chappell MD ,&nbsp;Kacy J. Peek MD ,&nbsp;A. Bobby Chhabra MD ,&nbsp;Brent R. DeGeorge Jr. MD, PhD","doi":"10.1016/j.jhsg.2025.100922","DOIUrl":"10.1016/j.jhsg.2025.100922","url":null,"abstract":"<div><h3>Purpose</h3><div>Mentorship is critical to the professional and personal development of surgical trainees, influencing clinical competence and career advancement. Although mentorship during residency has been widely studied, little is known about mentorship experiences during hand surgery fellowship, a brief and high stakes training period requiring rapid relationship formation. This study explored mentorship experiences and satisfaction among hand surgery fellows and to assess how personality traits, demographics, and program factors influence mentorship quality.</div></div><div><h3>Methods</h3><div>A mixed-methods study was conducted across 10 US hand surgery fellowship programs with Institutional Review Board approval. Participants completed an online questionnaire assessing demographics, fellowship characteristics, mentorship satisfaction, and personality traits. Semistructured interviews were conducted, transcribed, and analyzed using inductive content analysis to identify common themes. Quantitative data were analyzed using descriptive statistics, Pearson correlations, and analysis of variance with significance set at <em>P</em> &lt; .05.</div></div><div><h3>Results</h3><div>A total of 10 fellows from 10 programs participated. Fellows valued personal mentor attributes (eg, altruism, honesty, patience) over relational and professional qualities and rated shared demographics as least important. Mentorship satisfaction showed nonsignificant trends: higher satisfaction among fellows who rated themselves as more emotionally stable and lower satisfaction among those scoring higher in openness to experience. Program structure showed similar trends, with greater satisfaction reported by fellows with more mentors and fewer cofellows. Qualitative analysis identified seven themes: (1) ideal mentor qualities, (2) organic relationship building, (3) mutual investment and communication, (4) diverse mentor expertise, (5) demographics and representation, (6) sponsorship beyond mentorship, and (7) dealing with time and other challenges.</div></div><div><h3>Conclusions</h3><div>Hand surgery fellows reported overall positive mentorship experiences and emphasized personal qualities over demographic similarity. Although quantitative associations were limited by sample size, trends suggest that personality traits and program structure may influence mentorship satisfaction. Recognizing these dynamics may help fellowship directors identify trainees at risk for poor mentorship alignment and implement early, targeted support within the 1-year fellowship’s limited timeframe.</div></div><div><h3>Type of study/level of evidence</h3><div>Differential diagnosis/symptom prevalence study IV.</div></div>","PeriodicalId":36920,"journal":{"name":"Journal of Hand Surgery Global Online","volume":"8 2","pages":"Article 100922"},"PeriodicalIF":0.0,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Propensity Score-Matched Comparison of Ultrasound-Guided Versus Open Carpal Tunnel Release: Three-Month Outcomes From the MISSION Registry 超声引导与开放腕管松解术的倾向评分匹配比较:来自MISSION注册中心的三个月结果
Q3 Medicine Pub Date : 2026-01-21 DOI: 10.1016/j.jhsg.2025.100931
Victor M. Marwin MD, MBA , Christopher J. Lincoski MD , Johnny T. Nelson MD , James F. Watt DO , Amy T. Moeller MD , Paul E. Perry MD , Nicholas A. Bontempo MD , Steven R. Niedermeier MD , Larry E. Miller PhD, PStat , Kyle J. Moyles MD, MBA

Purpose

The purpose of the study was to compare the safety and effectiveness of ultrasound-guided carpal tunnel release (UGCTR) and open carpal tunnel release (OCTR) in real-world clinical settings.

Methods

Patients with carpal tunnel syndrome were prospectively enrolled in the multicenter MISSION registry and treated with unilateral UGCTR or OCTR by experienced surgeons. Outcomes included the Boston Carpal Tunnel Questionnaire Symptom Severity and Boston Carpal Tunnel Questionnaire Functional Status Scale, pain (0–10 scale), opioid use, health-related quality of life (EuroQoL 5-Dimension 5-Level), satisfaction (overall and wound), and adverse events through 3 months. Baseline group characteristics were balanced using propensity score matching.

Results

A total of 178 patients per group were analyzed. The predominant anesthesia methods differed between groups (84.8% wide awake local anesthesia no tourniquet with UGCTR; 68.5% monitored anesthesia with OCTR). Ultrasound-guided carpal tunnel release was associated with shorter incisions (5.2 vs 16.5 mm) and less sutured wound closure (14.6% vs 100%), but longer procedure times (15 vs 6 minutes). At 3 months, UGCTR showed minor statistical advantages in Boston Carpal Tunnel Questionnaire Symptom Severity (group difference: −0.14 points), Boston Carpal Tunnel Questionnaire Functional Status Scale (group difference: −0.16 points), and pain severity (group difference: −0.6 points), with no statistical differences in EuroQoL 5-Dimension 5-Level (group difference: 0.03 points) or overall satisfaction (group difference: 4.9%). Opioid use was less common (10.2% vs 49.1%), wound satisfaction was higher (94.2% vs 84.0%), and wound symptoms were less severe after UGCTR (60.7% vs 22.8% with no sensitivity or pain). Nonserious adverse event rates were comparable (1.1% vs 0.0%).

Conclusions

Ultrasound-guided CTR and OCTR provided safe and effective symptom relief in routine clinical practice. Ultrasound-guided CTR was associated with less anesthesia, shorter incisions, reduced opioid use, and fewer wound symptoms, whereas procedure time was shorter with OCTR. Technique selection should be guided by shared decision making, considering patient expectations and surgeon’s judgment.

Type of study/level of evidence

Therapeutic II.
目的比较超声引导下腕管松解术(UGCTR)和开放式腕管松解术(OCTR)在临床应用中的安全性和有效性。方法将腕管综合征患者纳入多中心MISSION注册中心,由经验丰富的外科医生进行单侧UGCTR或OCTR治疗。结果包括波士顿腕管问卷症状严重程度和波士顿腕管问卷功能状态量表、疼痛(0-10分)、阿片类药物使用、健康相关生活质量(EuroQoL 5维5级)、满意度(整体和伤口)和3个月的不良事件。使用倾向评分匹配平衡基线组特征。结果每组共分析178例患者。两组间主要麻醉方式不同(UGCTR全醒局麻不带止血带84.8%,OCTR监护麻醉68.5%)。超声引导下的腕管释放术切口较短(5.2 vs 16.5 mm),缝合伤口愈合较少(14.6% vs 100%),但手术时间较长(15 vs 6分钟)。在3个月时,UGCTR在波士顿腕管问卷症状严重程度(组差:−0.14分)、波士顿腕管问卷功能状态量表(组差:−0.16分)和疼痛严重程度(组差:−0.6分)方面有轻微的统计学优势,而在EuroQoL 5-Dimension 5-Level(组差:0.03分)或总体满意度(组差:4.9%)方面无统计学差异。阿片类药物使用较少(10.2% vs 49.1%),伤口满意度较高(94.2% vs 84.0%), UGCTR后伤口症状较轻(60.7% vs 22.8%,无敏感或疼痛)。非严重不良事件发生率相当(1.1% vs 0.0%)。结论超声引导下CTR和OCTR在临床常规治疗中均能安全有效地缓解症状。超声引导CTR与较少的麻醉、更短的切口、减少阿片类药物的使用和更少的伤口症状相关,而OCTR的手术时间更短。技术选择应在共同决策的指导下,考虑患者的期望和外科医生的判断。研究类型/证据水平:治疗性II。
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引用次数: 0
Antidepressant Use and Risk of Reoperation After Distal Radius Open Reduction and Internal Fixation: A Propensity Score-Matched Cohort Study 抗抑郁药的使用和桡骨远端切开复位内固定后再手术的风险:一项倾向评分匹配的队列研究
Q3 Medicine Pub Date : 2026-01-21 DOI: 10.1016/j.jhsg.2025.100930
Firdavs Kurbanov BS , Christopher Dussik MD , Amy Phan MD , Zion Rouege BS , Danielle Wilbur MD , Constantinos Ketonis MD, PhD

Purpose

Antidepressant use is common and has been linked to impaired bone remodeling, but its effect on fracture healing after fixation remains unclear. The purpose of this study was to examine whether selective serotonin reuptake inhibitors (SSRIs) and, separately, agents that modulate serotonergic signaling but are not SSRIs (non-SSRI serotonergic antidepressants) were associated with unplanned return to the operating room (RTOR) after open reduction and internal fixation (ORIF) of distal radius fractures.

Methods

We performed a retrospective, propensity score-matched cohort study using TriNetX, a global federated research network that aggregates deidentified electronic health record data from large health care organizations. Adults who underwent surgery within 14 days of distal radius fracture diagnosis were included and the ORIF date served as the index. Two mutually exclusive exposure comparisons were analyzed: SSRI users versus nonusers and non-SSRI serotonergic users (serotonin-norepinephrine reuptake inhibitors), tricyclic antidepressants, serotonergic monoamine oxidase inhibitors, vortioxetine, or vilazodone versus nonusers, defined by ≥2 prescriptions in the 180 days preindex. Cohorts were balanced using 1:1 greedy nearest-neighbor propensity-score matching (caliper 0.10). The primary outcome was unplanned RTOR 30–365 days postindex, defined as nonunion repair or repeat fixation. We estimated absolute risk differences, risk ratios (RRs), and Cox hazard ratios (HRs) with 95% confidence intervals (CIs).

Results

After matching, 2,657 SSRI users and 2,197 non-SSRI serotonergic users were compared with equal numbers of nonusers. Unplanned RTOR occurred in 47 (1.8%) SSRI users versus 20 (0.8%) nonusers (ARD 1.0%, RR 2.35, HR 2.25; 95% CI 1.33–3.79). Non-SSRI serotonergic users had 52 events (2.4%) versus 14 (0.6%) in nonusers (ARD 1.7%, RR 3.71, HR 3.62; 95% CI 2.01–6.54). Findings were consistent across absolute risk comparisons and time-to-event analyses.

Conclusions

Preoperative antidepressant exposure to SSRIs or non-SSRI serotonergic agents was associated with a small but clinically relevant increase in unplanned reoperation after distal radius ORIF.

Type of study/level of evidence

Prognostic III.
目的抗抑郁药的使用是常见的,并且与骨重塑受损有关,但其对骨折固定后愈合的影响尚不清楚。本研究的目的是研究选择性5 -羟色胺再摄取抑制剂(SSRIs)和单独调节5 -羟色胺能信号但不是SSRIs(非ssri 5 -羟色胺能抗抑郁药)的药物是否与桡骨远端骨折切开复位内固定(ORIF)后意外返回手术室(RTOR)有关。方法我们使用TriNetX进行了一项回顾性、倾向评分匹配的队列研究,TriNetX是一个全球联合研究网络,汇集了来自大型医疗机构的未识别电子健康记录数据。在桡骨远端骨折诊断后14天内接受手术的成人纳入研究,ORIF日期作为指标。分析了两种相互排斥的暴露比较:SSRI使用者与非SSRI使用者和非SSRI 5 -羟色胺能使用者(5 -羟色胺-去甲肾上腺素再摄取抑制剂)、三环抗抑郁药、5 -羟色胺能单胺氧化酶抑制剂、沃替西汀或维拉唑酮与非使用者,在指数前180天内定义为≥2个处方。使用1:1贪婪最近邻倾向评分匹配(caliper 0.10)来平衡队列。主要终点为指数后30-365天的计划外RTOR,定义为骨不连修复或重复固定。我们以95%置信区间(ci)估计绝对风险差异、风险比(rr)和Cox风险比(hr)。结果匹配后,2,657名SSRI使用者和2,197名非SSRI血清素能使用者与同等数量的非使用者进行了比较。非计划RTOR发生在47例(1.8%)SSRI使用者和20例(0.8%)非SSRI使用者(风险比1.0%,相对危险度2.35,相对危险度2.25;95% CI 1.33-3.79)。非ssri血清素能服用者发生52起事件(2.4%),非服用者发生14起事件(0.6%)(ARD为1.7%,RR 3.71, HR 3.62; 95% CI 2.01-6.54)。绝对风险比较和事件时间分析的结果是一致的。结论术前抗抑郁暴露于ssri类或非ssri类血清素能药物与桡骨远端ORIF术后非计划再手术的小幅增加相关,但与临床相关。研究类型/证据水平预后
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引用次数: 0
Treatment of Dupuytren Contracture Recurrence After Surgery With Collagenase Clostridium Histolyticum: A Retrospective Multicenter Series 胶原酶溶组织梭菌治疗双子宫挛缩术后复发:一项回顾性多中心研究
Q3 Medicine Pub Date : 2026-01-20 DOI: 10.1016/j.jhsg.2025.100919
Clayton A. Peimer MD , Marie A. Badalamente PhD , Philip Blazar MD , Keith A. Denkler MD , William Dzwierzynski MD , Mark Elzik MD , F. Thomas D. Kaplan MD , Jason A. Nydick DO , Gary M. Pess MD , James Verheyden MD , Mark A. Vitale MD , Jeffrey Andrews MS , Qinfang Xiang PhD , David Hurley MD , Lawrence C. Hurst MD

Purpose

Dupuytren contracture (DC) is a fibroproliferative disorder characterized by collagen deposition in the palmar fascia. Treatment options include collagenase clostridium histolyticum (CCH) injection and surgery; however, DC frequently recurs after primary therapy. We hypothesized that CCH treatment could be effective and well tolerated for the treatment of contracture recurrence for patients unwilling to undergo reoperation or at high risk for complications.

Methods

This Phase 4, multicenter, noninterventional, retrospective study analyzed medical records from 10 clinical centers in the US. Patients were treated with CCH for DC recurrence ≥6 months after previously successful surgical correction performed between January 1, 2010, and August 15, 2020. Primary end points were the measured joint contracture change from baseline, at first and last clinical evaluation within 12 months of CCH treatment of metacarpophalangeal (MP) and proximal interphalangeal (PIP) joint contractures. Secondary end points were “clinical success” (percentage of joints with reduction in contracture to 0° to 5°) and adverse events.

Results

Of 113 patients screened, 101 were analyzed (mean age, 64.1 years; 75% men). Median time to DC recurrence was 36.0 months. A total of 144 treated joints were analyzed (MP, n = 64; PIP, n = 75; unspecified, n = 5). Overall mean (SD) baseline contracture was 52° (21°) (MP, 43° [19°]; PIP, 61° [20°]). Mean (SD) improvement of contracture from baseline at last evaluation was 38° (21°) for all joints (MP, 36° [17°]; PIP, 41° [24°]), with 58% of joints having clinical success (MP, 75%; PIP, 43%). All skin tears (20 events in 19% of patients) resolved spontaneously, with 50% resolving in ≤21 days; there was one flexor profundus rupture that did not require secondary reconstruction.

Conclusions

This retrospective analysis indicates that CCH treatment is an effective and well tolerated nonsurgical option for recurrent postsurgical contracture, with results comparable to patients without prior surgery.

Type of study/level of evidence

Therapeutic III.
目的贲门挛缩(DC)是一种以掌筋膜胶原沉积为特征的纤维增生性疾病。治疗方案包括胶原酶溶组织梭菌(CCH)注射和手术;然而,DC经常在初次治疗后复发。我们假设,对于不愿再手术或有并发症高风险的患者,CCH治疗可能是有效且耐受性良好的。方法:本4期、多中心、非介入、回顾性研究分析了美国10个临床中心的病历。在2010年1月1日至2020年8月15日期间,既往成功手术矫正后DC复发≥6个月的患者接受CCH治疗。主要终点是在CCH治疗掌指关节(MP)和近端指间关节(PIP)挛缩的12个月内,从基线开始测量的关节挛缩变化,首次和最后一次临床评估。次要终点是“临床成功率”(关节挛缩减少到0°至5°的百分比)和不良事件。结果在筛选的113例患者中,分析了101例(平均年龄64.1岁,75%为男性)。到DC复发的中位时间为36.0个月。共分析了144个处理过的关节(MP, n = 64; PIP, n = 75;未指定,n = 5)。总体平均(SD)基线挛缩为52°(21°)(MP, 43°[19°];PIP, 61°[20°])。所有关节在最后一次评估时挛缩较基线改善的平均(SD)为38°(21°)(MP, 36°[17°];PIP, 41°[24°]),58%的关节获得临床成功(MP, 75%; PIP, 43%)。所有皮肤撕裂(19%患者中20例)自发消退,50%在≤21天内消退;有一个深屈肌破裂,不需要二次重建。结论:本回顾性分析表明,CCH治疗是一种有效且耐受性良好的非手术治疗复发性术后挛缩的选择,其结果与未手术的患者相当。研究类型/证据水平:治疗性
{"title":"Treatment of Dupuytren Contracture Recurrence After Surgery With Collagenase Clostridium Histolyticum: A Retrospective Multicenter Series","authors":"Clayton A. Peimer MD ,&nbsp;Marie A. Badalamente PhD ,&nbsp;Philip Blazar MD ,&nbsp;Keith A. Denkler MD ,&nbsp;William Dzwierzynski MD ,&nbsp;Mark Elzik MD ,&nbsp;F. Thomas D. Kaplan MD ,&nbsp;Jason A. Nydick DO ,&nbsp;Gary M. Pess MD ,&nbsp;James Verheyden MD ,&nbsp;Mark A. Vitale MD ,&nbsp;Jeffrey Andrews MS ,&nbsp;Qinfang Xiang PhD ,&nbsp;David Hurley MD ,&nbsp;Lawrence C. Hurst MD","doi":"10.1016/j.jhsg.2025.100919","DOIUrl":"10.1016/j.jhsg.2025.100919","url":null,"abstract":"<div><h3>Purpose</h3><div>Dupuytren contracture (DC) is a fibroproliferative disorder characterized by collagen deposition in the palmar fascia. Treatment options include collagenase clostridium histolyticum (CCH) injection and surgery; however, DC frequently recurs after primary therapy. We hypothesized that CCH treatment could be effective and well tolerated for the treatment of contracture recurrence for patients unwilling to undergo reoperation or at high risk for complications.</div></div><div><h3>Methods</h3><div>This Phase 4, multicenter, noninterventional, retrospective study analyzed medical records from 10 clinical centers in the US. Patients were treated with CCH for DC recurrence ≥6 months after previously successful surgical correction performed between January 1, 2010, and August 15, 2020. Primary end points were the measured joint contracture change from baseline, at first and last clinical evaluation within 12 months of CCH treatment of metacarpophalangeal (MP) and proximal interphalangeal (PIP) joint contractures. Secondary end points were “clinical success” (percentage of joints with reduction in contracture to 0° to 5°) and adverse events.</div></div><div><h3>Results</h3><div>Of 113 patients screened, 101 were analyzed (mean age, 64.1 years; 75% men). Median time to DC recurrence was 36.0 months. A total of 144 treated joints were analyzed (MP, <em>n</em> = 64; PIP, <em>n</em> = 75; unspecified, <em>n</em> = 5). Overall mean (SD) baseline contracture was 52° (21°) (MP, 43° [19°]; PIP, 61° [20°]). Mean (SD) improvement of contracture from baseline at last evaluation was 38° (21°) for all joints (MP, 36° [17°]; PIP, 41° [24°]), with 58% of joints having clinical success (MP, 75%; PIP, 43%). All skin tears (20 events in 19% of patients) resolved spontaneously, with 50% resolving in ≤21 days; there was one flexor profundus rupture that did not require secondary reconstruction.</div></div><div><h3>Conclusions</h3><div>This retrospective analysis indicates that CCH treatment is an effective and well tolerated nonsurgical option for recurrent postsurgical contracture, with results comparable to patients without prior surgery.</div></div><div><h3>Type of study/level of evidence</h3><div>Therapeutic III.</div></div>","PeriodicalId":36920,"journal":{"name":"Journal of Hand Surgery Global Online","volume":"8 2","pages":"Article 100919"},"PeriodicalIF":0.0,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations Between Area Deprivation Index and the Time to Presentation of Scaphoid Fractures 面积剥夺指数与舟状骨骨折出现时间的关系
Q3 Medicine Pub Date : 2026-01-19 DOI: 10.1016/j.jhsg.2025.100932
Aidan M. Lynch BS, MS , Muhammad H. Hamdan BS , Jordan Bauer MD , Rohan V. Rajan BS , Rajendra Singh BS , Joel V. Ferreira MD , Anthony Parrino MD , Craig M. Rodner MD

Purpose

Scaphoid fractures are the most common carpal fractures and are prone to nonunion because of their retrograde blood supply. Delayed diagnosis or treatment increases the risk of nonunion and progression to scaphoid nonunion advanced collapse. Social determinants of health, measured by the area deprivation index (ADI), may contribute to such delays. This study examines the association between ADI, time to presentation, and the presence of nonunion at initial evaluation.

Methods

A retrospective chart review identified 168 patients with suspected scaphoid fractures between January 1, 2018 and June 30, 2025. State-level ADI scores were grouped into the following terciles: least-deprived (LDT), intermediately deprived (IDT), and most deprived (MDT). Patients presenting more than 5 years after injury or without confirmed fractures were excluded, leaving a total of 107 patients. Independent t tests compared the mean time from injury to presentation across ADI terciles, χ2 tests compared the nonunion rates at presentation, and binomial regression assessed whether ADI predicted scaphoid nonunion.

Results

The mean time from injury to presentation increased with deprivation: LDT = 16.9 ± 23.5 days, IDT = 55.1 ± 97.9 days, and MDT = 173.5 ± 364.5 days. Both MDT and IDT patients presented significantly later than LDT patients (P = .0146 and P = .0315, respectively) and had a higher prevalence of nonunion at presentation (P = .025). The ADI independently predicted scaphoid nonunion, with each unit increase in state ADI associated with 23.8% higher odds of nonunion (P = .029).

Conclusions

Patients from socioeconomically deprived communities experienced significantly longer delays in presentation for scaphoid fractures and a higher incidence of nonunion, which may increase the risk of long-term complications such as scaphoid nonunion advanced collapse wrist arthritis. These findings highlight the importance of addressing neighborhood-level disparities to increase access to treatment in time-sensitive injuries such as scaphoid fractures.

Type of study/level of evidence

Prevalence IIIb.
目的:圆锥状骨折是最常见的腕骨骨折,由于其血液供应逆行,容易发生骨不愈合。延迟诊断或治疗会增加骨不连和进展为舟状骨不连晚期塌陷的风险。以地区剥夺指数(ADI)衡量的健康的社会决定因素可能造成这种延误。本研究探讨了初次评估时ADI、出现时间和骨不连之间的关系。方法回顾性分析2018年1月1日至2025年6月30日期间168例疑似舟状骨骨折患者。州一级的ADI得分分为以下三个等级:最不贫困(LDT)、中等贫困(IDT)和最贫困(MDT)。排除伤后5年以上或未确诊骨折的患者,共107例。独立t检验比较了从损伤到出现舟状骨不连的平均时间,χ2检验比较了出现舟状骨不连时的不连率,二项回归评估了ADI是否预测舟状骨不连。结果从损伤到出现的平均时间随剥夺时间的增加而增加:LDT = 16.9±23.5 d, IDT = 55.1±97.9 d, MDT = 173.5±364.5 d。MDT和IDT患者出现时间均明显晚于LDT患者(P = 0.0146和P = 0.0315),且出现骨不连的发生率较高(P = 0.025)。ADI独立预测舟状骨不愈合,ADI状态每增加一个单位,骨不愈合的几率增加23.8% (P = 0.029)。结论来自社会经济贫困社区的患者出现舟状骨骨折的时间明显较长,骨不连的发生率较高,这可能增加长期并发症的风险,如舟状骨不连晚期塌陷腕关节炎。这些发现强调了解决社区水平差异的重要性,以增加对舟状骨骨折等时间敏感损伤的治疗机会。研究类型/证据水平
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引用次数: 0
Quantification of Articular Surface Involvement During Intramedullary Fixation of the Phalanges 指骨髓内固定过程中关节面受累的定量分析
Q3 Medicine Pub Date : 2026-01-16 DOI: 10.1016/j.jhsg.2025.100928
Julie Mekhail MS, Rhiana Rivas BS, Carolyn A. Ardizzone MD, Jordan P. Pearce MD, Nikalus G. Skipp BS, Deana M. Mercer MD

Purpose

Phalangeal fractures of the hand are the second most common upper-extremity fracture in the United States. Numerous studies have reported on the biomechanical efficacy of intramedullary (IM) hand nail fixation of the phalanges and increased utilization of IM hand nails. During IM fixation, the nail often penetrates the articular cartilage during insertion. This study seeks to quantify the percentage of cartilage involvement created by anterograde and retrograde intramedullary fixation of proximal and middle phalangeal fractures with 3.0 mm and 3.5 mm IM threaded hand nails.

Methods

Thirty-two frozen fingers were studied from eight cadaveric hands. Four different techniques for nail placement were used: (1) retrograde across an unflexed distal interphalangeal joint, (2) retrograde across a flexed distal interphalangeal joint into the middle phalanx, (3) retrograde through a flexed proximal interphalangeal joint into the proximal phalanx, and 4) antegrade through the metacarpal phalangeal joint into the proximal phalanx. Clinical photographs and fluoroscopy images were taken for each specimen, and the articular cartilage damage was quantified using Image J software.

Results

The average articular involvement using intramedullary hand nails for phalangeal fixation was less than 10% of the articular surface regardless of nail placement technique and nail size (mean range 3.56% to 9.73%). The damaged area was always greater with the 3.5 mm than the 3.0 mm nails.

Conclusions

Our results are consistent with the literature. Our study is unique in that we compare the different methods of hand nail insertion and the different diameter hand nails and evaluate the degree of articular surface involvement in an approach that has not been tested on cadaveric models. Phalanx fracture fixation with intramedullary hand nails may be beneficial, as it has acceptable joint cartilage damage based on our study data.

Type of study/level of evidence

Bench research/laboratory study V.
目的手部指骨骨折是美国第二大最常见的上肢骨折。许多研究报道了髓内(IM)手钉固定指骨的生物力学效果和IM手钉的使用增加。在内固定过程中,钉常穿透关节软骨。本研究旨在量化用3.0 mm和3.5 mm IM螺纹手钉顺行和逆行髓内固定近端和中端指骨骨折所造成的软骨受累百分比。方法对8只尸体的32个冰冻手指进行研究。采用了四种不同的钉入技术:(1)逆行穿过不屈曲的远端指间关节,(2)逆行穿过屈曲的远端指间关节进入中指骨,(3)逆行通过屈曲的近端指间关节进入近端指骨,以及4)顺行通过掌指骨关节进入近端指骨。每个标本拍摄临床照片和透视图像,使用Image J软件对关节软骨损伤进行量化。结果采用髓内钉固定指骨,不论钉位方式和钉位大小,平均受累关节面小于关节面10%(平均范围3.56% ~ 9.73%)。3.5 mm钉的损伤面积大于3.0 mm钉。结论sour结果与文献一致。我们的研究是独一无二的,因为我们比较了不同的手指甲插入方法和不同直径的手指甲,并评估了关节面受损伤的程度,这种方法尚未在尸体模型上测试过。髓内手钉固定指骨骨折可能是有益的,因为根据我们的研究数据,它具有可接受的关节软骨损伤。研究类型/证据水平工作台研究/实验室研究
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引用次数: 0
期刊
Journal of Hand Surgery Global Online
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