{"title":"May home cardiorespiratory polygraphy be considered a realistic alternative to polysomnography for catathrenia screening?","authors":"Sameh Msaad , Sourour Abid , Issraa Wadhane , Rahma Gargouri , Nesrine Kallel , Fatma Triki , Nadia Moussa , Samy Kammoun","doi":"10.1016/j.sleepx.2023.100097","DOIUrl":"10.1016/j.sleepx.2023.100097","url":null,"abstract":"","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"7 ","pages":"Article 100097"},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S259014272300037X/pdfft?md5=cc39cf3a575dc2fdebb82bb659ded77f&pid=1-s2.0-S259014272300037X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139022000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-30DOI: 10.1016/j.sleepx.2023.100095
Maurice M. Ohayon , Stéphanie Duhoux , Joseph Grieco , Marie-Lise Côté
Objective
The objectives of this study are to evaluate the prevalence and incidence of Narcolepsy type 1 and type 2 and to determine the prevalence of narcolepsy diagnosis criteria in the US general population.
Methods
This longitudinal study was conducted in the adult US general population in two occasions. The initial interviews included 15 states (Arizona, California, Colorado, Florida, Idaho, Missouri, New York, North Carolina, North Dakota, Oregon, Pennsylvania, South Dakota, Texas, Washington, and Wyoming). The follow-up interviews, was done three years later in eight of these states. Of the 19,136 contacted individuals, 15,929 completed the initial interview and 10,931 completed the follow-up. Participants were interviewed using the Sleep-EVAL system, an artificial intelligence tool. Narcolepsy Type 1 (with cataplexy) and Narcolepsy Type 2 (without cataplexy) were defined according to the ICSD-3 classification. Symptoms of narcolepsy were assessed by frequency per week and duration. Medical visits and diagnoses were also collected.
Results
Participants were aged between 18 and 102 years of age (mean 45.8 ± 17.9 years), 51.3 % were women. The prevalence of narcolepsy with cataplexy was 12.6 per 100,000 individuals (95 % C.I., 0 to 30) and narcolepsy without cataplexy was 25.1 per 100,000. The incidence per year was 2.6 per 100,000 individuals (95 % C.I., 0 to 11).
Conclusions
Narcolepsy is a rare condition affecting 37.7/100,000 individuals (126,191 individuals in the current US population). Our US general population prevalence is in line with rates found in community-based studies but lower than what is reported in claim database studies.
{"title":"Prevalence and incidence of narcolepsy symptoms in the US general population","authors":"Maurice M. Ohayon , Stéphanie Duhoux , Joseph Grieco , Marie-Lise Côté","doi":"10.1016/j.sleepx.2023.100095","DOIUrl":"https://doi.org/10.1016/j.sleepx.2023.100095","url":null,"abstract":"<div><h3>Objective</h3><p>The objectives of this study are to evaluate the prevalence and incidence of Narcolepsy type 1 and type 2 and to determine the prevalence of narcolepsy diagnosis criteria in the US general population.</p></div><div><h3>Methods</h3><p>This longitudinal study was conducted in the adult US general population in two occasions. The initial interviews included 15 states (Arizona, California, Colorado, Florida, Idaho, Missouri, New York, North Carolina, North Dakota, Oregon, Pennsylvania, South Dakota, Texas, Washington, and Wyoming). The follow-up interviews, was done three years later in eight of these states. Of the 19,136 contacted individuals, 15,929 completed the initial interview and 10,931 completed the follow-up. Participants were interviewed using the Sleep-EVAL system, an artificial intelligence tool. Narcolepsy Type 1 (with cataplexy) and Narcolepsy Type 2 (without cataplexy) were defined according to the ICSD-3 classification. Symptoms of narcolepsy were assessed by frequency per week and duration. Medical visits and diagnoses were also collected.</p></div><div><h3>Results</h3><p>Participants were aged between 18 and 102 years of age (mean 45.8 ± 17.9 years), 51.3 % were women. The prevalence of narcolepsy with cataplexy was 12.6 per 100,000 individuals (95 % C.I., 0 to 30) and narcolepsy without cataplexy was 25.1 per 100,000. The incidence per year was 2.6 per 100,000 individuals (95 % C.I., 0 to 11).</p></div><div><h3>Conclusions</h3><p>Narcolepsy is a rare condition affecting 37.7/100,000 individuals (126,191 individuals in the current US population). Our US general population prevalence is in line with rates found in community-based studies but lower than what is reported in claim database studies.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"6 ","pages":"Article 100095"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590142723000356/pdfft?md5=3ea0cddca975ff7a3f32cd4f0d593dc4&pid=1-s2.0-S2590142723000356-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138502000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-19DOI: 10.1016/j.sleepx.2023.100094
Mengzhen Zhou , Rujia Liu , Jiyou Tang , Shi Tang
Background
Insomnia is a common disease, and the application of various types of sleeping pills for cognitive impairment is controversial, especially as different doses can lead to different effects. Therefore, it is necessary to evaluate the cognitive impairment caused by different sleeping pills to provide a theoretical basis for guiding clinicians in the selection of medication regimens.
Objective
To evaluate whether various different doses (low, medium and high) of anti-insomnia drugs, such as the dual-orexin receptor antagonist (DORA), zopiclone, eszopiclone and zolpidem, induce cognitive impairment.
Methods
The PubMed, Embase, Scopus, Cochrane Library, and Google Scholar databases were searched from inception to September 20th, 2022 for keywords in randomized controlled trials (RCTs) to evaluate the therapeutic effects of DORA, eszopiclone, zopiclone and zolpidem on sleep and cognitive function. The primary outcomes were indicators related to cognitive characteristics, including scores on the Digit Symbol Substitution Test (DSST) and daytime alertness. The secondary outcomes were the indicators associated with sleep and adverse events. Continuous variables were expressed as the standard mean difference (SMD). Data were obtained through GetData 2.26 and analyzed by Stata v.15.0.
Results
A total of 8702 subjects were included in 29 studies. Eszopiclonehigh significantly increased the daytime alertness score (SMD = 3.00, 95 % CI: 1.86 to 4.13) compared with the placebo, and eszopiclonehigh significantly increased the daytime alertness score (SMD = 4.21, 95 % CI: 1.65 to 6.77; SMD = 3.95, 95 % CI: 1.38 to 6.51; SMD = 3.26, 95 % CI: 0.38 to 6.15; and SMD = 3.23, 95 % CI: 0.34 to 6.11) compared with zolpidemlow, zolpidemhigh, DORAlow, and eszopiclonemid, respectively. Compared with the placebo, zopiclone, zolpidemmid, and eszopiclonehigh, DORA significantly increased the TST (SMD = 2.39, 95 % CI: 1.11 to 3.67; SMD = 6.00, 95 % CI: 2.73 to 9.27; SMD = 1.89, 95 % CI: 0.90 to 2.88; and SMD = 1.70, 95 % CI: 0.42 to 2.99, respectively).
Conclusion
We recommend DORA as the best intervention for insomnia because it was highly effective in inducing and maintaining sleep without impairing cognition. Although zolpidem had a more pronounced effect on sleep maintenance, this drug is better for short-term use. Eszopiclone and zopiclone improved sleep, but their cognitive effects have yet to be verified.
{"title":"Effects of new hypnotic drugs on cognition: A systematic review and network meta-analysis","authors":"Mengzhen Zhou , Rujia Liu , Jiyou Tang , Shi Tang","doi":"10.1016/j.sleepx.2023.100094","DOIUrl":"https://doi.org/10.1016/j.sleepx.2023.100094","url":null,"abstract":"<div><h3>Background</h3><p>Insomnia is a common disease, and the application of various types of sleeping pills for cognitive impairment is controversial, especially as different doses can lead to different effects. Therefore, it is necessary to evaluate the cognitive impairment caused by different sleeping pills to provide a theoretical basis for guiding clinicians in the selection of medication regimens.</p></div><div><h3>Objective</h3><p>To evaluate whether various different doses (low, medium and high) of anti-insomnia drugs, such as the dual-orexin receptor antagonist (DORA), zopiclone, eszopiclone and zolpidem, induce cognitive impairment.</p></div><div><h3>Methods</h3><p>The PubMed, Embase, Scopus, Cochrane Library, and Google Scholar databases were searched from inception to September 20th, 2022 for keywords in randomized controlled trials (RCTs) to evaluate the therapeutic effects of DORA, eszopiclone, zopiclone and zolpidem on sleep and cognitive function. The primary outcomes were indicators related to cognitive characteristics, including scores on the Digit Symbol Substitution Test (DSST) and daytime alertness. The secondary outcomes were the indicators associated with sleep and adverse events. Continuous variables were expressed as the standard mean difference (SMD). Data were obtained through GetData 2.26 and analyzed by Stata v.15.0.</p></div><div><h3>Results</h3><p>A total of 8702 subjects were included in 29 studies. Eszopiclone<sub>high</sub> significantly increased the daytime alertness score (SMD = 3.00, 95 % CI: 1.86 to 4.13) compared with the placebo, and eszopiclone<sub>high</sub> significantly increased the daytime alertness score (SMD = 4.21, 95 % CI: 1.65 to 6.77; SMD = 3.95, 95 % CI: 1.38 to 6.51; SMD = 3.26, 95 % CI: 0.38 to 6.15; and SMD = 3.23, 95 % CI: 0.34 to 6.11) compared with zolpidem<sub>low</sub>, zolpidem<sub>high</sub>, DORA<sub>low</sub>, and eszopiclone<sub>mid</sub>, respectively. Compared with the placebo, zopiclone, zolpidem<sub>mid</sub>, and eszopiclone<sub>high</sub>, DORA significantly increased the TST (SMD = 2.39, 95 % CI: 1.11 to 3.67; SMD = 6.00, 95 % CI: 2.73 to 9.27; SMD = 1.89, 95 % CI: 0.90 to 2.88; and SMD = 1.70, 95 % CI: 0.42 to 2.99, respectively).</p></div><div><h3>Conclusion</h3><p>We recommend DORA as the best intervention for insomnia because it was highly effective in inducing and maintaining sleep without impairing cognition. Although zolpidem had a more pronounced effect on sleep maintenance, this drug is better for short-term use. Eszopiclone and zopiclone improved sleep, but their cognitive effects have yet to be verified.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"6 ","pages":"Article 100094"},"PeriodicalIF":0.0,"publicationDate":"2023-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590142723000344/pdfft?md5=27a972fd6f684f2317abf7764b50f35c&pid=1-s2.0-S2590142723000344-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138501999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-14DOI: 10.1016/j.sleepx.2023.100093
Thea Christine Thorshov , Caroline Tonje Øverby , Diana Dobran Hansen , Way Kiat Bong , Knut Skifjeld , Petter Hurlen , Toril Dammen , Anne Moen , Harald Hrubos-Strøm
Background
Insomnia is the most common sleep disorder. The recommended treatment is cognitive behavioural therapy for insomnia (CBTi). A sleep diary is a core tool in CBTi. We have developed a digital sleep diary with a standardised feedback function.
Aim
To study feasibility of the digital sleep diary in participants of the Akershus Sleep Apnea (ASAP) cohorts with difficulties falling asleep or maintaining sleep. To describe sleep diary engagement and explore experiences with the digital sleep diary with potential influences in insomnia symptom management.
Material and methods
Twenty participants were recruited from the ASAP. All filled out a digital sleep diary up to 12 weeks. Treatment options provided were a self-help book (N = 11) or electroencephalography neurofeedback (N = 9) in addition to the sleep diary standardised feedback function. We collected quantitative data from the sleep diary reports and we sub-divided insomnia by sleep onset insomnia and non-sleep onset insomnia. Finally, we performed qualitative interviews.
Results
The median number of entries to the sleep diary was 81 (25th quartile: 26, 75th quartile 84). In the qualitative analysis, we identified two main themes; “structure and overview” and “usability and digital features”.
Conclusion
The sleep diary was found to be feasible when distributed in combination with a self-help book or electroencephalography neurofeedback. The qualitative results emphasised the importance of a timely graphical overview and visualisations of self-recorded sleep.
{"title":"Experience with the use of a digital sleep diary in symptom management by individuals with insomnia -a pilot mixed method study","authors":"Thea Christine Thorshov , Caroline Tonje Øverby , Diana Dobran Hansen , Way Kiat Bong , Knut Skifjeld , Petter Hurlen , Toril Dammen , Anne Moen , Harald Hrubos-Strøm","doi":"10.1016/j.sleepx.2023.100093","DOIUrl":"10.1016/j.sleepx.2023.100093","url":null,"abstract":"<div><h3>Background</h3><p>Insomnia is the most common sleep disorder. The recommended treatment is cognitive behavioural therapy for insomnia (CBTi). A sleep diary is a core tool in CBTi. We have developed a digital sleep diary with a standardised feedback function.</p></div><div><h3>Aim</h3><p>To study feasibility of the digital sleep diary in participants of the Akershus Sleep Apnea (ASAP) cohorts with difficulties falling asleep or maintaining sleep. To describe sleep diary engagement and explore experiences with the digital sleep diary with potential influences in insomnia symptom management.</p></div><div><h3>Material and methods</h3><p>Twenty participants were recruited from the ASAP. All filled out a digital sleep diary up to 12 weeks. Treatment options provided were a self-help book (N = 11) or electroencephalography neurofeedback (N = 9) in addition to the sleep diary standardised feedback function. We collected quantitative data from the sleep diary reports and we sub-divided insomnia by sleep onset insomnia and non-sleep onset insomnia. Finally, we performed qualitative interviews.</p></div><div><h3>Results</h3><p>The median number of entries to the sleep diary was 81 (25th quartile: 26, 75th quartile 84). In the qualitative analysis, we identified two main themes; “structure and overview” and “usability and digital features”.</p></div><div><h3>Conclusion</h3><p>The sleep diary was found to be feasible when distributed in combination with a self-help book or electroencephalography neurofeedback. The qualitative results emphasised the importance of a timely graphical overview and visualisations of self-recorded sleep.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"6 ","pages":"Article 100093"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590142723000332/pdfft?md5=886ad7d76d8c0d3a0aac595238c897ec&pid=1-s2.0-S2590142723000332-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135764373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-13DOI: 10.1016/j.sleepx.2023.100092
Saeed Jaydarifard , Simon S. Smith , Kalina R. Rossa , Dwayne Mann , Elahe Nikooharf Salehi , Shamsi Shekari Soleimanloo
Background
Current evidence suggests that precarious employment is a risk factor for poor mental health. Although the mechanisms underpinning this relationship are unclear, poor sleep has been proposed to have a role in this relationship. This study explored the mediating effects of poor sleep quality and duration on the relationship between precarious employment and mental health.
Methods
Data were obtained from wave 17 of the Household, Income and Labour Dynamics in Australia survey. A novel precarious employment score (PES) was developed using exploratory and confirmatory factor analyses (CFA) in 8127 workers (4195 female, aged 18–65). Structural equation modelling (SEM) was used to evaluate the mediating effect of sleep quality and duration on the relationship between precarious employment and mental health (SF-36 mental health subscale).
Results
The PES identified 650 workers with a high level of precariousness, 2417 with a moderate level of precariousness, and 5060 workers with a low level of precariousness out of 8127 in total. There was a significant direct association between precarious employment and mental health; with higher precarity increasing the likelihood of poor mental health. The SEM results revealed that sleep quality partially mediated the association between precarious employment and mental health (Coefficient = 0.025, 95 % CI [0.015, 0.034], P ≤ 0.001). However, a mediation effect was not found for sleep duration.
Conclusion
Encouraging precarious employees to improve sleep quality may mitigate the adverse effects of precarious work on their mental health. Further objective measurement of sleep duration warrants a more accurate insight into this mediating effect in this group.
背景:目前的证据表明,不稳定的就业是心理健康状况不佳的一个风险因素。尽管支撑这种关系的机制尚不清楚,但有人认为睡眠不足在这种关系中起着一定作用。本研究探讨了不稳定就业与心理健康关系中睡眠质量差和睡眠时长的中介作用。方法数据来自澳大利亚家庭、收入和劳动力动态调查的第17轮。采用探索性和验证性因素分析(CFA)对8127名工人(4195名女性,年龄在18-65岁)进行了新的不稳定就业评分(PES)。采用结构方程模型(SEM)评估睡眠质量和持续时间在不稳定就业与心理健康(SF-36心理健康量表)关系中的中介作用。结果在8127名工人中,PES确定了650名工人具有高不稳定性,2417名工人具有中等不稳定性,5060名工人具有低不稳定性。不稳定就业与心理健康之间存在显著的直接关联;随着不稳定性的增加,心理健康状况不佳的可能性也在增加。扫描电镜结果显示,睡眠质量部分介导了不稳定就业与心理健康之间的关联(系数= 0.025,95% CI [0.015, 0.034], P≤0.001)。然而,睡眠时间没有中介效应。结论鼓励不稳定员工提高睡眠质量可以减轻不稳定工作对其心理健康的不利影响。对睡眠持续时间的进一步客观测量保证了对这一群体的中介作用的更准确的洞察。
{"title":"Sleep mediates the relationship between precarious employment and mental health","authors":"Saeed Jaydarifard , Simon S. Smith , Kalina R. Rossa , Dwayne Mann , Elahe Nikooharf Salehi , Shamsi Shekari Soleimanloo","doi":"10.1016/j.sleepx.2023.100092","DOIUrl":"10.1016/j.sleepx.2023.100092","url":null,"abstract":"<div><h3>Background</h3><p>Current evidence suggests that precarious employment is a risk factor for poor mental health. Although the mechanisms underpinning this relationship are unclear, poor sleep has been proposed to have a role in this relationship. This study explored the mediating effects of poor sleep quality and duration on the relationship between precarious employment and mental health.</p></div><div><h3>Methods</h3><p>Data were obtained from wave 17 of the Household, Income and Labour Dynamics in Australia survey. A novel precarious employment score (PES) was developed using exploratory and confirmatory factor analyses (CFA) in 8127 workers (4195 female, aged 18–65). Structural equation modelling (SEM) was used to evaluate the mediating effect of sleep quality and duration on the relationship between precarious employment and mental health (SF-36 mental health subscale).</p></div><div><h3>Results</h3><p>The PES identified 650 workers with a high level of precariousness, 2417 with a moderate level of precariousness, and 5060 workers with a low level of precariousness out of 8127 in total. There was a significant direct association between precarious employment and mental health; with higher precarity increasing the likelihood of poor mental health. The SEM results revealed that sleep quality partially mediated the association between precarious employment and mental health (Coefficient = 0.025, 95 % CI [0.015, 0.034], P ≤ 0.001). However, a mediation effect was not found for sleep duration.</p></div><div><h3>Conclusion</h3><p>Encouraging precarious employees to improve sleep quality may mitigate the adverse effects of precarious work on their mental health. Further objective measurement of sleep duration warrants a more accurate insight into this mediating effect in this group.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"6 ","pages":"Article 100092"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590142723000320/pdfft?md5=92cf29358a243662403d9af1ef02c6f6&pid=1-s2.0-S2590142723000320-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135714400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-15DOI: 10.1016/j.sleepx.2023.100091
Pearl Angeli Diamante , Maria Cecilia Jocson , Artemio Roxas Jr.
Objectives
This study aimed to describe the knowledge, attitudes, and practices of Filipino adult neurologists in the recognition and treatment of obstructive sleep apnea (OSA) among patients presenting with acute stroke.
Methodology
A prospective cross-sectional study was conducted using a web-based survey from April to June 2022 among active locally-practicing adult neurology fellows of the Philippine Neurological Association. The 18-item knowledge statements from the validated “Obstructive Sleep Apnea Knowledge and Attitudes (OSAKA) Questionnaire was used as survey instrument. There were also eight additional items assessing knowledge, six items assessing attitudes, and ten items assessing practices that were included.
Results
A total of 119 neurologists participated in the survey. Two-thirds of the respondents were females, and 70 % were between 31 and 40 years old. Majority of the respondents are General Neurologists (57.1 %) followed by Neurophysiologists (10 %) and Stroke Specialists (10 %). Forty-seven percent of neurologists got more than or equal to 75 % of the knowledge statements included in the OSAKA questionnaire correctly. Less than half of the respondents correctly answered the questions on (1) uvulopalatopharyngoplasty as curative for majority of patients with OSA (32.8 %), (2) continuous positive airway pressure (CPAP) therapy can cause nasal congestion (42.9 %), (3) laser-assisted uvuloplasty as treatment for severe OSA (16.8 %), and (4) less than 5 apneas is normal in adults (48.7 %). Majority (>80 %) of the respondents were able to correctly answer the statements relating OSA and stroke. Almost all agreed that OSA as a clinical disorder (95 %) is important and that acute stroke patients with possible OSA needs to be identified (94.1 %) and further evaluated (96.6 %). On the other hand, less than half of the respondents feel confident in: identifying patients at-risk for OSA (47.9 %), ability to manage acute stroke patients with OSA (34.5 %), and ability to manage acute stroke patients with OSA on CPAP therapy (21 %). Most neurologists would sometimes screen OSA among their patients with acute stroke (55.5 %). Most respondents would only educate their patients on OSA sometimes (43.7 %). With regards to the diagnosis (42 %), risk factors (42 %), and treatment options for OSA (40.3 %), most would discuss them with their patients.
Conclusion
Less than half of neurologists were able to get at least 75 % of the knowledge questions. Majority had difficulty with statements pertaining to surgery as cure for OSA, CPAP therapy causing nasal congestion, and OSA severity classification. Almost all has a positive attitude towards the importance of OSA diagnosis and management; however, there is low confidence among them with regards to their practice in identification and handling of these patients.
{"title":"Knowledge, attitude, and practices of Filipino adult neurologists on obstructive sleep apnea among stroke patients","authors":"Pearl Angeli Diamante , Maria Cecilia Jocson , Artemio Roxas Jr.","doi":"10.1016/j.sleepx.2023.100091","DOIUrl":"https://doi.org/10.1016/j.sleepx.2023.100091","url":null,"abstract":"<div><h3>Objectives</h3><p>This study aimed to describe the knowledge, attitudes, and practices of Filipino adult neurologists in the recognition and treatment of obstructive sleep apnea (OSA) among patients presenting with acute stroke.</p></div><div><h3>Methodology</h3><p>A prospective cross-sectional study was conducted using a web-based survey from April to June 2022 among active locally-practicing adult neurology fellows of the Philippine Neurological Association. The 18-item knowledge statements from the validated “Obstructive Sleep Apnea Knowledge and Attitudes (OSAKA) Questionnaire was used as survey instrument. There were also eight additional items assessing knowledge, six items assessing attitudes, and ten items assessing practices that were included.</p></div><div><h3>Results</h3><p>A total of 119 neurologists participated in the survey. Two-thirds of the respondents were females, and 70 % were between 31 and 40 years old. Majority of the respondents are General Neurologists (57.1 %) followed by Neurophysiologists (10 %) and Stroke Specialists (10 %). Forty-seven percent of neurologists got more than or equal to 75 % of the knowledge statements included in the OSAKA questionnaire correctly. Less than half of the respondents correctly answered the questions on (1) uvulopalatopharyngoplasty as curative for majority of patients with OSA (32.8 %), (2) continuous positive airway pressure (CPAP) therapy can cause nasal congestion (42.9 %), (3) laser-assisted uvuloplasty as treatment for severe OSA (16.8 %), and (4) less than 5 apneas is normal in adults (48.7 %). Majority (>80 %) of the respondents were able to correctly answer the statements relating OSA and stroke. Almost all agreed that OSA as a clinical disorder (95 %) is important and that acute stroke patients with possible OSA needs to be identified (94.1 %) and further evaluated (96.6 %). On the other hand, less than half of the respondents feel confident in: identifying patients at-risk for OSA (47.9 %), ability to manage acute stroke patients with OSA (34.5 %), and ability to manage acute stroke patients with OSA on CPAP therapy (21 %). Most neurologists would sometimes screen OSA among their patients with acute stroke (55.5 %). Most respondents would only educate their patients on OSA sometimes (43.7 %). With regards to the diagnosis (42 %), risk factors (42 %), and treatment options for OSA (40.3 %), most would discuss them with their patients.</p></div><div><h3>Conclusion</h3><p>Less than half of neurologists were able to get at least 75 % of the knowledge questions. Majority had difficulty with statements pertaining to surgery as cure for OSA, CPAP therapy causing nasal congestion, and OSA severity classification. Almost all has a positive attitude towards the importance of OSA diagnosis and management; however, there is low confidence among them with regards to their practice in identification and handling of these patients.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"6 ","pages":"Article 100091"},"PeriodicalIF":0.0,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49816418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-14DOI: 10.1016/j.sleepx.2023.100090
Khaled Al Oweidat , Ahmad A. Toubasi , Thuraya N. Al-Sayegh , Rima A. Sinan , Sara H. Mansour , Hanna K. Makhamreh
Background
Despite the considerable knowledge of Obstructive Sleep Apnea (OSA) implications for cardiac diseases, the evidence regarding cardiovascular complications across OSA phenotypes including Rapid Eye Movement OSA (REM-OSA) and Positional OSA (POSA) is limited. In this study, we aimed to evaluate the risk of cardiovascular diseases development and progression among patients with REM-OSA and POSA.
Methods
Based on a retrospective cohort analysis, we included polysomnography studies done in the sleep lab at the Jordan University Hospital. Regarding cardiovascular diseases, primary outcomes were Heart Failure, and 1-years Major Adverse Cardiac Events while secondary outcomes were atrial fibrillation, pulmonary hypertension, other arrhythmia, metabolic profile, and echocardiographic measurements of the heart.
Results
The total number of the included patients was 1,026 patients. POSA group had significantly lower percentage of patients with hypertension (P-value = 0.004). Additionally, systolic blood pressure and HbA1c were significantly lower among patients with POSA compared to the NPOSA group (P-value<0.050). Left ventricular end diastolic dimension was significantly higher among patients with POSA while ejection fraction was significantly lower (P-value<0.050). Patients with diabetes and mean HbA1c were significantly lower among patients with REM-OSA compared to patients with NREM-OSA (P-value = 0.015, P-value = 0.046). Multivariate regression analysis revealed that after adjusting for age, gender and preexisting comorbidities, POSA was significantly associated with lower ejection fraction and higher left ventricular diastolic diameter.
Conclusion
In conclusion, our findings indicate that POSA might be associated with huge and clinically significant heart strain and poor cardiac functions, yet it might not have a clinically significant atherogenic effect. This study should guide clinicians to identify OSA phenotypes to imply the best treatment plan to reduce its detrimental impact on cardiac muscle.
{"title":"Cardiovascular diseases across OSA phenotypes: A retrospective cohort study","authors":"Khaled Al Oweidat , Ahmad A. Toubasi , Thuraya N. Al-Sayegh , Rima A. Sinan , Sara H. Mansour , Hanna K. Makhamreh","doi":"10.1016/j.sleepx.2023.100090","DOIUrl":"https://doi.org/10.1016/j.sleepx.2023.100090","url":null,"abstract":"<div><h3>Background</h3><p>Despite the considerable knowledge of Obstructive Sleep Apnea (OSA) implications for cardiac diseases, the evidence regarding cardiovascular complications across OSA phenotypes including Rapid Eye Movement OSA (REM-OSA) and Positional OSA (POSA) is limited. In this study, we aimed to evaluate the risk of cardiovascular diseases development and progression among patients with REM-OSA and POSA.</p></div><div><h3>Methods</h3><p>Based on a retrospective cohort analysis, we included polysomnography studies done in the sleep lab at the Jordan University Hospital. Regarding cardiovascular diseases, primary outcomes were Heart Failure, and 1-years Major Adverse Cardiac Events while secondary outcomes were atrial fibrillation, pulmonary hypertension, other arrhythmia, metabolic profile, and echocardiographic measurements of the heart.</p></div><div><h3>Results</h3><p>The total number of the included patients was 1,026 patients. POSA group had significantly lower percentage of patients with hypertension (P-value = 0.004). Additionally, systolic blood pressure and HbA1c were significantly lower among patients with POSA compared to the NPOSA group (P-value<0.050). Left ventricular end diastolic dimension was significantly higher among patients with POSA while ejection fraction was significantly lower (P-value<0.050). Patients with diabetes and mean HbA1c were significantly lower among patients with REM-OSA compared to patients with NREM-OSA (P-value = 0.015, P-value = 0.046). Multivariate regression analysis revealed that after adjusting for age, gender and preexisting comorbidities, POSA was significantly associated with lower ejection fraction and higher left ventricular diastolic diameter.</p></div><div><h3>Conclusion</h3><p>In conclusion, our findings indicate that POSA might be associated with huge and clinically significant heart strain and poor cardiac functions, yet it might not have a clinically significant atherogenic effect. This study should guide clinicians to identify OSA phenotypes to imply the best treatment plan to reduce its detrimental impact on cardiac muscle.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"6 ","pages":"Article 100090"},"PeriodicalIF":0.0,"publicationDate":"2023-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49775638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-12DOI: 10.1016/j.sleepx.2023.100089
Mantavya Punj , Aakash Desai , Jana G. Hashash , Francis A. Farraye , Pablo R. Castillo
Objectives
Examine risks for breakthrough COVID-19 infections in vaccinated patients with selected sleep disorders.
Methods
Real-time search and analysis using the TriNetX platform to evaluate risk of COVID-19 breakthrough infections (BTI) for patients having ICD-10 diagnoses relating to insomnia, circadian rhythm disorders, and inadequate sleep. The sleep disorder and control cohorts underwent propensity matching including factors for age, gender, race, ethnicity, and multiple co-morbid conditions.
Results
Of 24,720 patients identified as having a sleep disturbance relating to insomnia, circadian rhythm disorder, or inadequate sleep, 815 (3.2 %) were found to have a developed a BTI. There was a significant increased risk of BTI noted between the sleep disorder and control cohorts (adjusted odds ratio (aOR) of 1.40, 95 % confidence interval (CI) of 1.23–1.58). Subgroup analysis showed an elevated risk for BTI receiving two doses (aOR 1.53, 95 % CI 1.24–1.89) versus three doses (aOR 1.45, 95 % CI 1.24–1.69). Patients with the sleep disturbance were not found to be at an increased risk of hospitalization, intubation, death, or composite outcome of death and intubation.
Conclusion
The presence of having a diagnosis of insomnia, circadian rhythm disorder, or inadequate sleep was associated with increased risk of COVID-19 breakthrough infection.
{"title":"COVID-19 breakthrough infections and sleep disorders: A population-based propensity matched analysis","authors":"Mantavya Punj , Aakash Desai , Jana G. Hashash , Francis A. Farraye , Pablo R. Castillo","doi":"10.1016/j.sleepx.2023.100089","DOIUrl":"https://doi.org/10.1016/j.sleepx.2023.100089","url":null,"abstract":"<div><h3>Objectives</h3><p>Examine risks for breakthrough COVID-19 infections in vaccinated patients with selected sleep disorders.</p></div><div><h3>Methods</h3><p>Real-time search and analysis using the TriNetX platform to evaluate risk of COVID-19 breakthrough infections (BTI) for patients having ICD-10 diagnoses relating to insomnia, circadian rhythm disorders, and inadequate sleep. The sleep disorder and control cohorts underwent propensity matching including factors for age, gender, race, ethnicity, and multiple co-morbid conditions.</p></div><div><h3>Results</h3><p>Of 24,720 patients identified as having a sleep disturbance relating to insomnia, circadian rhythm disorder, or inadequate sleep, 815 (3.2 %) were found to have a developed a BTI. There was a significant increased risk of BTI noted between the sleep disorder and control cohorts (adjusted odds ratio (aOR) of 1.40, 95 % confidence interval (CI) of 1.23–1.58). Subgroup analysis showed an elevated risk for BTI receiving two doses (aOR 1.53, 95 % CI 1.24–1.89) versus three doses (aOR 1.45, 95 % CI 1.24–1.69). Patients with the sleep disturbance were not found to be at an increased risk of hospitalization, intubation, death, or composite outcome of death and intubation.</p></div><div><h3>Conclusion</h3><p>The presence of having a diagnosis of insomnia, circadian rhythm disorder, or inadequate sleep was associated with increased risk of COVID-19 breakthrough infection.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"6 ","pages":"Article 100089"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49816417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-07DOI: 10.1016/j.sleepx.2023.100088
Laura Castro-Santos , Márcia de Oliveira Lima , Anny Kariny Pereira Pedrosa , Renan Serenini , Risia Cristina Egito de Menezes , Giovana Longo-Silva
Objective
To investigate the association of sleep and circadian hygiene practices (sleep-promoting and sleep-disturbing behaviors) with sleep quality indicators.
Methods
Participants (n = 2050; 18–65 y) were part of virtual population-based research. Logistic regression models were fitted to assess differences in the OR (95% CI) of poor quality with sleep-promoting/disturbing practices (time-of-day of exercise, pre-bedtime routine, naps, electronic devices with illuminated screens, caffeine and alcohol consumption, and smoking). Linear regression analyses evaluated differences in sleep duration, latency, and awakenings associated with the same variables. Restricted cubic splines were used to study the shape of the association of screen time before bed with sleep duration, latency, and awakenings. Analyses were adjusted for age, sex, region, marital status, educational level, evening diet quality, and BMI.
Results
Evening use of electronic devices with illuminated screens showed a negative effect on all sleep parameters. Reporting dinner as the largest meal and evening caffeine consumption was associated with shorter sleep duration and longer sleep latency. Smokers had higher odds of longer latency. A protective effect of morning exercises was demonstrated on sleep quality, latency, and awakenings. Alcohol consumers presented lower odds of poor quality and lower frequency of awakenings. Pre-bedtime practices showed no or negative effect on sleep outcomes.
Conclusions
Recommendations to promote sleep quality and prevent sleep-related problems, with corresponding circadian health benefits, should include engaging in regular exercise, preferably in the morning, and avoiding naps, heavy meals close to bedtime, caffeine, smoking, and evening screen exposure.
{"title":"Sleep and circadian hygiene practices association with sleep quality among Brazilian adults","authors":"Laura Castro-Santos , Márcia de Oliveira Lima , Anny Kariny Pereira Pedrosa , Renan Serenini , Risia Cristina Egito de Menezes , Giovana Longo-Silva","doi":"10.1016/j.sleepx.2023.100088","DOIUrl":"https://doi.org/10.1016/j.sleepx.2023.100088","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the association of sleep and circadian hygiene practices (sleep-promoting and sleep-disturbing behaviors) with sleep quality indicators.</p></div><div><h3>Methods</h3><p>Participants (n = 2050; 18–65 y) were part of virtual population-based research. Logistic regression models were fitted to assess differences in the OR (95% CI) of poor quality with sleep-promoting/disturbing practices (time-of-day of exercise, pre-bedtime routine, naps, electronic devices with illuminated screens, caffeine and alcohol consumption, and smoking). Linear regression analyses evaluated differences in sleep duration, latency, and awakenings associated with the same variables. Restricted cubic splines were used to study the shape of the association of screen time before bed with sleep duration, latency, and awakenings. Analyses were adjusted for age, sex, region, marital status, educational level, evening diet quality, and BMI.</p></div><div><h3>Results</h3><p>Evening use of electronic devices with illuminated screens showed a negative effect on all sleep parameters. Reporting dinner as the largest meal and evening caffeine consumption was associated with shorter sleep duration and longer sleep latency. Smokers had higher odds of longer latency. A protective effect of morning exercises was demonstrated on sleep quality, latency, and awakenings. Alcohol consumers presented lower odds of poor quality and lower frequency of awakenings. Pre-bedtime practices showed no or negative effect on sleep outcomes.</p></div><div><h3>Conclusions</h3><p>Recommendations to promote sleep quality and prevent sleep-related problems, with corresponding circadian health benefits, should include engaging in regular exercise, preferably in the morning, and avoiding naps, heavy meals close to bedtime, caffeine, smoking, and evening screen exposure.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"6 ","pages":"Article 100088"},"PeriodicalIF":0.0,"publicationDate":"2023-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49775637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-27DOI: 10.1016/j.sleepx.2023.100087
Tereza Dvořáková , Radana Měrková , Jitka Bušková
Objective
This study aimed to determine the frequency, type, and correlates of a broad spectrum of sleep disorders in adults with COVID-19 up to 32 months after infection.
Methods
We conducted a national online survey (Jun 2021–Dec 2022), gathering information on COVID-19 diagnosis, acute disease course, and the subsequent development of sleep disorders from 1507 respondents (mean age 44.5 ± 13.1 years, 64.1% women).
Results
81.3% (1223) reported at least one sleep difficulty that either worsened or first appeared with COVID-19. Females reported a higher number of symptoms (2.03 ± 1.44 versus 1.72 ± 1.43 in men, p < 0.0001). Most common were insomnia symptoms (59.4%), followed by night sweats (38.4%), hypersomnolence (33.3%), vivid dreams or nightmares (26.4%), restless leg syndrome (RLS) (22.8%), and sleep-related breathing disorders (11.1%). All symptoms were associated with a more severe acute disease. A mild decreasing trend in the persistence of sleep symptoms with a longer latency since infection was observed, with 66.7% reporting at least half of their symptoms present at 3–5 months after acute infection, compared to 64.9% at 6–8 months, and 62.4% at 9–11 months (p = 0.0427). However, among those after 12 or more months, over half of the symptoms persisted in 69.5%. The frequency of vivid dreams and nightmares increased in association with COVID-19 in 32.9% (p < 0.001). 9.4% (141) reported new-onset or increased parasomnic manifestations after the infection.
Conclusions
Our research shows that sleep disturbances are a common and persistent manifestation of COVID-19 that affects a large proportion of the population and deserves careful monitoring.
{"title":"Sleep disorders after COVID-19 in Czech population: Post-lockdown national online survey","authors":"Tereza Dvořáková , Radana Měrková , Jitka Bušková","doi":"10.1016/j.sleepx.2023.100087","DOIUrl":"10.1016/j.sleepx.2023.100087","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to determine the frequency, type, and correlates of a broad spectrum of sleep disorders in adults with COVID-19 up to 32 months after infection.</p></div><div><h3>Methods</h3><p>We conducted a national online survey (Jun 2021–Dec 2022), gathering information on COVID-19 diagnosis, acute disease course, and the subsequent development of sleep disorders from 1507 respondents (mean age 44.5 ± 13.1 years, 64.1% women).</p></div><div><h3>Results</h3><p>81.3% (1223) reported at least one sleep difficulty that either worsened or first appeared with COVID-19. Females reported a higher number of symptoms (2.03 ± 1.44 versus 1.72 ± 1.43 in men, p < 0.0001). Most common were insomnia symptoms (59.4%), followed by night sweats (38.4%), hypersomnolence (33.3%), vivid dreams or nightmares (26.4%), restless leg syndrome (RLS) (22.8%), and sleep-related breathing disorders (11.1%). All symptoms were associated with a more severe acute disease. A mild decreasing trend in the persistence of sleep symptoms with a longer latency since infection was observed, with 66.7% reporting at least half of their symptoms present at 3–5 months after acute infection, compared to 64.9% at 6–8 months, and 62.4% at 9–11 months (p = 0.0427). However, among those after 12 or more months, over half of the symptoms persisted in 69.5%. The frequency of vivid dreams and nightmares increased in association with COVID-19 in 32.9% (p < 0.001). 9.4% (141) reported new-onset or increased parasomnic manifestations after the infection.</p></div><div><h3>Conclusions</h3><p>Our research shows that sleep disturbances are a common and persistent manifestation of COVID-19 that affects a large proportion of the population and deserves careful monitoring.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"6 ","pages":"Article 100087"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/30/a3/main.PMC10551886.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41137183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}