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May home cardiorespiratory polygraphy be considered a realistic alternative to polysomnography for catathrenia screening? 在白内障筛查中,家庭心肺功能测谎仪是否可以替代多导睡眠图?
Q1 Medicine Pub Date : 2023-12-18 DOI: 10.1016/j.sleepx.2023.100097
Sameh Msaad , Sourour Abid , Issraa Wadhane , Rahma Gargouri , Nesrine Kallel , Fatma Triki , Nadia Moussa , Samy Kammoun
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引用次数: 0
Prevalence and incidence of narcolepsy symptoms in the US general population 美国普通人群中发作性睡病症状的患病率和发病率
Q1 Medicine Pub Date : 2023-11-30 DOI: 10.1016/j.sleepx.2023.100095
Maurice M. Ohayon , Stéphanie Duhoux , Joseph Grieco , Marie-Lise Côté

Objective

The objectives of this study are to evaluate the prevalence and incidence of Narcolepsy type 1 and type 2 and to determine the prevalence of narcolepsy diagnosis criteria in the US general population.

Methods

This longitudinal study was conducted in the adult US general population in two occasions. The initial interviews included 15 states (Arizona, California, Colorado, Florida, Idaho, Missouri, New York, North Carolina, North Dakota, Oregon, Pennsylvania, South Dakota, Texas, Washington, and Wyoming). The follow-up interviews, was done three years later in eight of these states. Of the 19,136 contacted individuals, 15,929 completed the initial interview and 10,931 completed the follow-up. Participants were interviewed using the Sleep-EVAL system, an artificial intelligence tool. Narcolepsy Type 1 (with cataplexy) and Narcolepsy Type 2 (without cataplexy) were defined according to the ICSD-3 classification. Symptoms of narcolepsy were assessed by frequency per week and duration. Medical visits and diagnoses were also collected.

Results

Participants were aged between 18 and 102 years of age (mean 45.8 ± 17.9 years), 51.3 % were women. The prevalence of narcolepsy with cataplexy was 12.6 per 100,000 individuals (95 % C.I., 0 to 30) and narcolepsy without cataplexy was 25.1 per 100,000. The incidence per year was 2.6 per 100,000 individuals (95 % C.I., 0 to 11).

Conclusions

Narcolepsy is a rare condition affecting 37.7/100,000 individuals (126,191 individuals in the current US population). Our US general population prevalence is in line with rates found in community-based studies but lower than what is reported in claim database studies.

目的本研究的目的是评估1型和2型发作性睡病的患病率和发病率,并确定发作性睡病在美国普通人群中的患病率诊断标准。方法本纵向研究分两次在美国成年普通人群中进行。最初的访谈包括15个州(亚利桑那州、加利福尼亚州、科罗拉多州、佛罗里达州、爱达荷州、密苏里州、纽约州、北卡罗来纳州、北达科他州、俄勒冈州、宾夕法尼亚州、南达科他州、德克萨斯州、华盛顿州和怀俄明州)。后续访谈是三年后在其中八个州进行的。在19136名接触者中,15929人完成了初次访谈,10931人完成了随访。参与者使用人工智能工具Sleep-EVAL系统进行访谈。发作性睡病1型(伴猝倒)和发作性睡病2型(无猝倒)根据ICSD-3分类进行定义。发作性睡病的症状通过每周发作频率和持续时间进行评估。还收集了就诊和诊断情况。结果参与者年龄18 ~ 102岁(平均45.8±17.9岁),女性占51.3%。发作性睡病伴猝倒的患病率为12.6 / 10万人(95% ci,0 ~ 30),无猝倒的发作性睡病患病率为25.1 / 10万人。每年的发病率为每10万人2.6例(95% ci,0 ~ 11)。结论嗜睡是一种罕见的疾病,影响37.7/10万人(目前美国人口中有126,191人)。我们的美国一般人群患病率与社区研究中发现的比率一致,但低于索赔数据库研究中报告的比率。
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引用次数: 0
Effects of new hypnotic drugs on cognition: A systematic review and network meta-analysis 新型催眠药物对认知的影响:系统综述和网络荟萃分析
Q1 Medicine Pub Date : 2023-11-19 DOI: 10.1016/j.sleepx.2023.100094
Mengzhen Zhou , Rujia Liu , Jiyou Tang , Shi Tang

Background

Insomnia is a common disease, and the application of various types of sleeping pills for cognitive impairment is controversial, especially as different doses can lead to different effects. Therefore, it is necessary to evaluate the cognitive impairment caused by different sleeping pills to provide a theoretical basis for guiding clinicians in the selection of medication regimens.

Objective

To evaluate whether various different doses (low, medium and high) of anti-insomnia drugs, such as the dual-orexin receptor antagonist (DORA), zopiclone, eszopiclone and zolpidem, induce cognitive impairment.

Methods

The PubMed, Embase, Scopus, Cochrane Library, and Google Scholar databases were searched from inception to September 20th, 2022 for keywords in randomized controlled trials (RCTs) to evaluate the therapeutic effects of DORA, eszopiclone, zopiclone and zolpidem on sleep and cognitive function. The primary outcomes were indicators related to cognitive characteristics, including scores on the Digit Symbol Substitution Test (DSST) and daytime alertness. The secondary outcomes were the indicators associated with sleep and adverse events. Continuous variables were expressed as the standard mean difference (SMD). Data were obtained through GetData 2.26 and analyzed by Stata v.15.0.

Results

A total of 8702 subjects were included in 29 studies. Eszopiclonehigh significantly increased the daytime alertness score (SMD = 3.00, 95 % CI: 1.86 to 4.13) compared with the placebo, and eszopiclonehigh significantly increased the daytime alertness score (SMD = 4.21, 95 % CI: 1.65 to 6.77; SMD = 3.95, 95 % CI: 1.38 to 6.51; SMD = 3.26, 95 % CI: 0.38 to 6.15; and SMD = 3.23, 95 % CI: 0.34 to 6.11) compared with zolpidemlow, zolpidemhigh, DORAlow, and eszopiclonemid, respectively. Compared with the placebo, zopiclone, zolpidemmid, and eszopiclonehigh, DORA significantly increased the TST (SMD = 2.39, 95 % CI: 1.11 to 3.67; SMD = 6.00, 95 % CI: 2.73 to 9.27; SMD = 1.89, 95 % CI: 0.90 to 2.88; and SMD = 1.70, 95 % CI: 0.42 to 2.99, respectively).

Conclusion

We recommend DORA as the best intervention for insomnia because it was highly effective in inducing and maintaining sleep without impairing cognition. Although zolpidem had a more pronounced effect on sleep maintenance, this drug is better for short-term use. Eszopiclone and zopiclone improved sleep, but their cognitive effects have yet to be verified.

失眠是一种常见的疾病,不同类型的安眠药用于认知障碍的应用存在争议,特别是不同剂量会导致不同的效果。因此,有必要对不同安眠药引起的认知障碍进行评估,为指导临床医生选择用药方案提供理论依据。目的评价双食欲素受体拮抗剂(DORA)、佐匹克隆、艾司佐匹克隆、唑吡坦等不同剂量(低、中、高)抗失眠药物对认知功能损害的影响。方法检索PubMed、Embase、Scopus、Cochrane Library、Google Scholar等数据库,检索自成立之日至2022年9月20日的随机对照试验(rct)关键词,评价朵拉、艾司佐匹克隆、佐匹克隆和唑吡坦对睡眠和认知功能的影响。主要结果是与认知特征相关的指标,包括数字符号替代测试(DSST)的分数和白天的警觉性。次要结果是与睡眠和不良事件相关的指标。连续变量用标准均差(SMD)表示。数据通过GetData 2.26获取,使用Stata v.15.0进行分析。结果29项研究共纳入8702名受试者。与安慰剂相比,Eszopiclonehigh显著提高了日间警惕性评分(SMD = 3.00, 95% CI: 1.86 ~ 4.13), Eszopiclonehigh显著提高了日间警惕性评分(SMD = 4.21, 95% CI: 1.65 ~ 6.77;SMD = 3.95, 95% CI: 1.38 ~ 6.51;SMD = 3.26, 95% CI: 0.38 ~ 6.15;SMD = 3.23, 95% CI: 0.34 ~ 6.11),分别与zolpidlow、zolpidhigh、dorallow和eszopiclonemid相比。与安慰剂、佐匹克隆、唑吡胺和艾索匹克隆相比,DORA显著提高了TST (SMD = 2.39, 95% CI: 1.11 ~ 3.67;SMD = 6.00, 95% CI: 2.73 ~ 9.27;SMD = 1.89, 95% CI: 0.90 ~ 2.88;SMD = 1.70, 95% CI分别为0.42 ~ 2.99)。结论朵拉能有效诱导和维持睡眠,且不影响认知功能,是治疗失眠症的最佳干预措施。虽然唑吡坦对维持睡眠有更明显的效果,但这种药物更适合短期使用。艾索匹克隆和佐匹克隆改善了睡眠,但它们对认知的影响尚未得到证实。
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引用次数: 0
Experience with the use of a digital sleep diary in symptom management by individuals with insomnia -a pilot mixed method study 在失眠症患者症状管理中使用数字睡眠日记的经验-一项试点混合方法研究
Q1 Medicine Pub Date : 2023-11-14 DOI: 10.1016/j.sleepx.2023.100093
Thea Christine Thorshov , Caroline Tonje Øverby , Diana Dobran Hansen , Way Kiat Bong , Knut Skifjeld , Petter Hurlen , Toril Dammen , Anne Moen , Harald Hrubos-Strøm

Background

Insomnia is the most common sleep disorder. The recommended treatment is cognitive behavioural therapy for insomnia (CBTi). A sleep diary is a core tool in CBTi. We have developed a digital sleep diary with a standardised feedback function.

Aim

To study feasibility of the digital sleep diary in participants of the Akershus Sleep Apnea (ASAP) cohorts with difficulties falling asleep or maintaining sleep. To describe sleep diary engagement and explore experiences with the digital sleep diary with potential influences in insomnia symptom management.

Material and methods

Twenty participants were recruited from the ASAP. All filled out a digital sleep diary up to 12 weeks. Treatment options provided were a self-help book (N = 11) or electroencephalography neurofeedback (N = 9) in addition to the sleep diary standardised feedback function. We collected quantitative data from the sleep diary reports and we sub-divided insomnia by sleep onset insomnia and non-sleep onset insomnia. Finally, we performed qualitative interviews.

Results

The median number of entries to the sleep diary was 81 (25th quartile: 26, 75th quartile 84). In the qualitative analysis, we identified two main themes; “structure and overview” and “usability and digital features”.

Conclusion

The sleep diary was found to be feasible when distributed in combination with a self-help book or electroencephalography neurofeedback. The qualitative results emphasised the importance of a timely graphical overview and visualisations of self-recorded sleep.

失眠是最常见的睡眠障碍。推荐的治疗方法是失眠的认知行为疗法(CBTi)。睡眠日记是cbt的核心工具。我们开发了一个带有标准化反馈功能的数字睡眠日记。研究数字睡眠日记在Akershus睡眠呼吸暂停(ASAP)队列中入睡或维持睡眠困难的参与者中的可行性。描述睡眠日记的参与情况,并探索使用数字睡眠日记对失眠症状管理的潜在影响。从ASAP招募了20名参与者。所有人都填写了一份长达12周的电子睡眠日记。除睡眠日记标准化反馈功能外,提供的治疗选择是自助书(N = 11)或脑电图神经反馈(N = 9)。我们从睡眠日记报告中收集定量数据,并将失眠细分为睡眠性失眠和非睡眠性失眠。最后,我们进行了定性访谈。睡眠日记条目的中位数为81条(第25四分位数:26条,第75四分位数84条)。在定性分析中,我们确定了两个主要主题;“结构和概述”和“可用性和数字特性”。研究发现,当睡眠日记与自助书或脑电图神经反馈结合使用时,是可行的。定性结果强调了及时的图形概述和自我记录睡眠可视化的重要性。
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引用次数: 0
Sleep mediates the relationship between precarious employment and mental health 睡眠调节不稳定就业与心理健康之间的关系
Q1 Medicine Pub Date : 2023-11-13 DOI: 10.1016/j.sleepx.2023.100092
Saeed Jaydarifard , Simon S. Smith , Kalina R. Rossa , Dwayne Mann , Elahe Nikooharf Salehi , Shamsi Shekari Soleimanloo

Background

Current evidence suggests that precarious employment is a risk factor for poor mental health. Although the mechanisms underpinning this relationship are unclear, poor sleep has been proposed to have a role in this relationship. This study explored the mediating effects of poor sleep quality and duration on the relationship between precarious employment and mental health.

Methods

Data were obtained from wave 17 of the Household, Income and Labour Dynamics in Australia survey. A novel precarious employment score (PES) was developed using exploratory and confirmatory factor analyses (CFA) in 8127 workers (4195 female, aged 18–65). Structural equation modelling (SEM) was used to evaluate the mediating effect of sleep quality and duration on the relationship between precarious employment and mental health (SF-36 mental health subscale).

Results

The PES identified 650 workers with a high level of precariousness, 2417 with a moderate level of precariousness, and 5060 workers with a low level of precariousness out of 8127 in total. There was a significant direct association between precarious employment and mental health; with higher precarity increasing the likelihood of poor mental health. The SEM results revealed that sleep quality partially mediated the association between precarious employment and mental health (Coefficient = 0.025, 95 % CI [0.015, 0.034], P ≤ 0.001). However, a mediation effect was not found for sleep duration.

Conclusion

Encouraging precarious employees to improve sleep quality may mitigate the adverse effects of precarious work on their mental health. Further objective measurement of sleep duration warrants a more accurate insight into this mediating effect in this group.

背景:目前的证据表明,不稳定的就业是心理健康状况不佳的一个风险因素。尽管支撑这种关系的机制尚不清楚,但有人认为睡眠不足在这种关系中起着一定作用。本研究探讨了不稳定就业与心理健康关系中睡眠质量差和睡眠时长的中介作用。方法数据来自澳大利亚家庭、收入和劳动力动态调查的第17轮。采用探索性和验证性因素分析(CFA)对8127名工人(4195名女性,年龄在18-65岁)进行了新的不稳定就业评分(PES)。采用结构方程模型(SEM)评估睡眠质量和持续时间在不稳定就业与心理健康(SF-36心理健康量表)关系中的中介作用。结果在8127名工人中,PES确定了650名工人具有高不稳定性,2417名工人具有中等不稳定性,5060名工人具有低不稳定性。不稳定就业与心理健康之间存在显著的直接关联;随着不稳定性的增加,心理健康状况不佳的可能性也在增加。扫描电镜结果显示,睡眠质量部分介导了不稳定就业与心理健康之间的关联(系数= 0.025,95% CI [0.015, 0.034], P≤0.001)。然而,睡眠时间没有中介效应。结论鼓励不稳定员工提高睡眠质量可以减轻不稳定工作对其心理健康的不利影响。对睡眠持续时间的进一步客观测量保证了对这一群体的中介作用的更准确的洞察。
{"title":"Sleep mediates the relationship between precarious employment and mental health","authors":"Saeed Jaydarifard ,&nbsp;Simon S. Smith ,&nbsp;Kalina R. Rossa ,&nbsp;Dwayne Mann ,&nbsp;Elahe Nikooharf Salehi ,&nbsp;Shamsi Shekari Soleimanloo","doi":"10.1016/j.sleepx.2023.100092","DOIUrl":"10.1016/j.sleepx.2023.100092","url":null,"abstract":"<div><h3>Background</h3><p>Current evidence suggests that precarious employment is a risk factor for poor mental health. Although the mechanisms underpinning this relationship are unclear, poor sleep has been proposed to have a role in this relationship. This study explored the mediating effects of poor sleep quality and duration on the relationship between precarious employment and mental health.</p></div><div><h3>Methods</h3><p>Data were obtained from wave 17 of the Household, Income and Labour Dynamics in Australia survey. A novel precarious employment score (PES) was developed using exploratory and confirmatory factor analyses (CFA) in 8127 workers (4195 female, aged 18–65). Structural equation modelling (SEM) was used to evaluate the mediating effect of sleep quality and duration on the relationship between precarious employment and mental health (SF-36 mental health subscale).</p></div><div><h3>Results</h3><p>The PES identified 650 workers with a high level of precariousness, 2417 with a moderate level of precariousness, and 5060 workers with a low level of precariousness out of 8127 in total. There was a significant direct association between precarious employment and mental health; with higher precarity increasing the likelihood of poor mental health. The SEM results revealed that sleep quality partially mediated the association between precarious employment and mental health (Coefficient = 0.025, 95 % CI [0.015, 0.034], P ≤ 0.001). However, a mediation effect was not found for sleep duration.</p></div><div><h3>Conclusion</h3><p>Encouraging precarious employees to improve sleep quality may mitigate the adverse effects of precarious work on their mental health. Further objective measurement of sleep duration warrants a more accurate insight into this mediating effect in this group.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"6 ","pages":"Article 100092"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590142723000320/pdfft?md5=92cf29358a243662403d9af1ef02c6f6&pid=1-s2.0-S2590142723000320-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135714400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge, attitude, and practices of Filipino adult neurologists on obstructive sleep apnea among stroke patients 菲律宾成年神经学家对脑卒中患者阻塞性睡眠呼吸暂停的知识、态度和实践
Q1 Medicine Pub Date : 2023-10-15 DOI: 10.1016/j.sleepx.2023.100091
Pearl Angeli Diamante , Maria Cecilia Jocson , Artemio Roxas Jr.

Objectives

This study aimed to describe the knowledge, attitudes, and practices of Filipino adult neurologists in the recognition and treatment of obstructive sleep apnea (OSA) among patients presenting with acute stroke.

Methodology

A prospective cross-sectional study was conducted using a web-based survey from April to June 2022 among active locally-practicing adult neurology fellows of the Philippine Neurological Association. The 18-item knowledge statements from the validated “Obstructive Sleep Apnea Knowledge and Attitudes (OSAKA) Questionnaire was used as survey instrument. There were also eight additional items assessing knowledge, six items assessing attitudes, and ten items assessing practices that were included.

Results

A total of 119 neurologists participated in the survey. Two-thirds of the respondents were females, and 70 % were between 31 and 40 years old. Majority of the respondents are General Neurologists (57.1 %) followed by Neurophysiologists (10 %) and Stroke Specialists (10 %). Forty-seven percent of neurologists got more than or equal to 75 % of the knowledge statements included in the OSAKA questionnaire correctly. Less than half of the respondents correctly answered the questions on (1) uvulopalatopharyngoplasty as curative for majority of patients with OSA (32.8 %), (2) continuous positive airway pressure (CPAP) therapy can cause nasal congestion (42.9 %), (3) laser-assisted uvuloplasty as treatment for severe OSA (16.8 %), and (4) less than 5 apneas is normal in adults (48.7 %). Majority (>80 %) of the respondents were able to correctly answer the statements relating OSA and stroke. Almost all agreed that OSA as a clinical disorder (95 %) is important and that acute stroke patients with possible OSA needs to be identified (94.1 %) and further evaluated (96.6 %). On the other hand, less than half of the respondents feel confident in: identifying patients at-risk for OSA (47.9 %), ability to manage acute stroke patients with OSA (34.5 %), and ability to manage acute stroke patients with OSA on CPAP therapy (21 %). Most neurologists would sometimes screen OSA among their patients with acute stroke (55.5 %). Most respondents would only educate their patients on OSA sometimes (43.7 %). With regards to the diagnosis (42 %), risk factors (42 %), and treatment options for OSA (40.3 %), most would discuss them with their patients.

Conclusion

Less than half of neurologists were able to get at least 75 % of the knowledge questions. Majority had difficulty with statements pertaining to surgery as cure for OSA, CPAP therapy causing nasal congestion, and OSA severity classification. Almost all has a positive attitude towards the importance of OSA diagnosis and management; however, there is low confidence among them with regards to their practice in identification and handling of these patients.

目的本研究旨在描述菲律宾成年神经学家在急性脑卒中患者中对阻塞性睡眠呼吸暂停(OSA)的认识和治疗方面的知识、态度和实践。方法2022年4月至6月,在菲律宾神经病学协会活跃的本地执业成年神经病学研究员中进行了一项前瞻性横断面研究。经验证的“阻塞性睡眠呼吸暂停知识和态度(OSAKA)”中的18项知识陈述问卷作为调查工具。此外,还包括8个评估知识的附加项目、6个评估态度的项目和10个评估实践的项目。结果共有119名神经科医生参与了调查。三分之二的受访者是女性,70%的受访者年龄在31至40岁之间。大多数受访者是普通神经学家(57.1%),其次是神经生理学家(10%)和中风专家(10%)。47%的神经学家对OSAKA问卷中包含的知识陈述的正确率超过或等于75%。不到一半的受访者正确回答了以下问题:(1)悬雍垂腭咽成形术对大多数OSA患者具有治疗作用(32.8%);(2)持续气道正压通气(CPAP)治疗可导致鼻塞(42.9%);(3)激光辅助悬雍垂成形术治疗严重OSA(16.8%),(4)低于5次呼吸暂停在成年人中是正常的(48.7%)。大多数(>;80%)受访者能够正确回答与OSA和中风有关的陈述。几乎所有人都认为OSA是一种临床疾病(95%)很重要,需要识别(94.1%)和进一步评估(96.6%)可能患有OSA的急性中风患者。另一方面,只有不到一半的受访者对以下方面有信心:识别OSA风险患者(47.9%)、管理OSA急性中风患者的能力(34.5%),以及在CPAP治疗中管理OSA急性卒中患者的能力(21%)。大多数神经学家有时会在急性中风患者中筛查OSA(55.5%)。大多数受访者有时只会对患者进行OSA教育(43.7%)。关于OSA的诊断(42%)、风险因素(42%)和治疗方案(40.3%),大多数人会与患者讨论。结论只有不到一半的神经学家能够获得至少75%的知识问题。大多数人对手术治疗OSA、CPAP治疗引起鼻塞和OSA严重程度分类的说法有困难。几乎所有人都对OSA诊断和管理的重要性持积极态度;然而,他们对自己在识别和处理这些患者方面的实践缺乏信心。
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引用次数: 0
Cardiovascular diseases across OSA phenotypes: A retrospective cohort study 不同OSA表型的心血管疾病:回顾性队列研究
Q1 Medicine Pub Date : 2023-10-14 DOI: 10.1016/j.sleepx.2023.100090
Khaled Al Oweidat , Ahmad A. Toubasi , Thuraya N. Al-Sayegh , Rima A. Sinan , Sara H. Mansour , Hanna K. Makhamreh

Background

Despite the considerable knowledge of Obstructive Sleep Apnea (OSA) implications for cardiac diseases, the evidence regarding cardiovascular complications across OSA phenotypes including Rapid Eye Movement OSA (REM-OSA) and Positional OSA (POSA) is limited. In this study, we aimed to evaluate the risk of cardiovascular diseases development and progression among patients with REM-OSA and POSA.

Methods

Based on a retrospective cohort analysis, we included polysomnography studies done in the sleep lab at the Jordan University Hospital. Regarding cardiovascular diseases, primary outcomes were Heart Failure, and 1-years Major Adverse Cardiac Events while secondary outcomes were atrial fibrillation, pulmonary hypertension, other arrhythmia, metabolic profile, and echocardiographic measurements of the heart.

Results

The total number of the included patients was 1,026 patients. POSA group had significantly lower percentage of patients with hypertension (P-value = 0.004). Additionally, systolic blood pressure and HbA1c were significantly lower among patients with POSA compared to the NPOSA group (P-value<0.050). Left ventricular end diastolic dimension was significantly higher among patients with POSA while ejection fraction was significantly lower (P-value<0.050). Patients with diabetes and mean HbA1c were significantly lower among patients with REM-OSA compared to patients with NREM-OSA (P-value = 0.015, P-value = 0.046). Multivariate regression analysis revealed that after adjusting for age, gender and preexisting comorbidities, POSA was significantly associated with lower ejection fraction and higher left ventricular diastolic diameter.

Conclusion

In conclusion, our findings indicate that POSA might be associated with huge and clinically significant heart strain and poor cardiac functions, yet it might not have a clinically significant atherogenic effect. This study should guide clinicians to identify OSA phenotypes to imply the best treatment plan to reduce its detrimental impact on cardiac muscle.

背景尽管对阻塞性睡眠呼吸暂停(OSA)对心脏疾病的影响有相当多的了解,但关于OSA表型心血管并发症的证据有限,包括快速眼动OSA(REM-OSA)和体位性OSA(POSA)。在这项研究中,我们旨在评估REM-OSA和POSA患者心血管疾病发展和进展的风险。方法基于回顾性队列分析,我们纳入了在约旦大学医院睡眠实验室进行的多导睡眠图研究。关于心血管疾病,主要转归为心力衰竭和1年重大心脏不良事件,次要转归为心房颤动、肺动脉高压、其他心律失常、代谢谱和心脏超声心动图测量。结果纳入的患者总数为1026例。POSA组高血压患者比例显著降低(P值=0.004),与NPOSA组相比,POSA患者的收缩压和HbA1c显著降低(P值<;0.050)。POSA患者左心室舒张末期尺寸显著升高,而射血分数显著降低(P值<)NREM-OSA患者(P值=0.015,P值=0.046)。多变量回归分析显示,在校正了年龄、性别和先前存在的合并症后,POSA与较低的射血分数和较高的左心室舒张直径显著相关。结论总之,我们的研究结果表明,POSA可能与巨大且具有临床意义的心脏应变和较差的心功能有关,但它可能没有临床意义的致动脉粥样硬化作用。这项研究应指导临床医生识别OSA表型,以暗示减少其对心肌有害影响的最佳治疗计划。
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引用次数: 0
COVID-19 breakthrough infections and sleep disorders: A population-based propensity matched analysis 新冠肺炎突破性感染与睡眠障碍:基于人群的倾向匹配分析
Q1 Medicine Pub Date : 2023-10-12 DOI: 10.1016/j.sleepx.2023.100089
Mantavya Punj , Aakash Desai , Jana G. Hashash , Francis A. Farraye , Pablo R. Castillo

Objectives

Examine risks for breakthrough COVID-19 infections in vaccinated patients with selected sleep disorders.

Methods

Real-time search and analysis using the TriNetX platform to evaluate risk of COVID-19 breakthrough infections (BTI) for patients having ICD-10 diagnoses relating to insomnia, circadian rhythm disorders, and inadequate sleep. The sleep disorder and control cohorts underwent propensity matching including factors for age, gender, race, ethnicity, and multiple co-morbid conditions.

Results

Of 24,720 patients identified as having a sleep disturbance relating to insomnia, circadian rhythm disorder, or inadequate sleep, 815 (3.2 %) were found to have a developed a BTI. There was a significant increased risk of BTI noted between the sleep disorder and control cohorts (adjusted odds ratio (aOR) of 1.40, 95 % confidence interval (CI) of 1.23–1.58). Subgroup analysis showed an elevated risk for BTI receiving two doses (aOR 1.53, 95 % CI 1.24–1.89) versus three doses (aOR 1.45, 95 % CI 1.24–1.69). Patients with the sleep disturbance were not found to be at an increased risk of hospitalization, intubation, death, or composite outcome of death and intubation.

Conclusion

The presence of having a diagnosis of insomnia, circadian rhythm disorder, or inadequate sleep was associated with increased risk of COVID-19 breakthrough infection.

目的研究接种疫苗的选定睡眠障碍患者发生突破性新冠肺炎感染的风险。方法使用TriNetX平台实时搜索和分析,评估ICD-10诊断为失眠、昼夜节律紊乱和睡眠不足的患者患新冠肺炎突破性感染(BTI)的风险。睡眠障碍和对照组进行了倾向匹配,包括年龄、性别、种族、民族和多种合并疾病的因素。结果24720名患者中,815名(3.2%)出现了BTI,这些患者被确定患有与失眠、昼夜节律紊乱或睡眠不足有关的睡眠障碍。在睡眠障碍和对照组之间发现BTI的风险显著增加(调整比值比(aOR)为1.40,95%置信区间(CI)为1.23-1.58)。亚组分析显示,接受两剂(aOR 1.53,95%CI 1.24-1.89)BTI的风险高于接受三剂(aOR1.45,95%CI 1.23-1.69)BTI。没有发现睡眠障碍患者住院、插管、死亡或死亡和插管复合结果的风险增加。结论诊断为失眠、昼夜节律紊乱或睡眠不足与新冠肺炎突破性感染风险增加有关。
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引用次数: 0
Sleep and circadian hygiene practices association with sleep quality among Brazilian adults 巴西成年人睡眠和昼夜卫生习惯与睡眠质量的关系
Q1 Medicine Pub Date : 2023-10-07 DOI: 10.1016/j.sleepx.2023.100088
Laura Castro-Santos , Márcia de Oliveira Lima , Anny Kariny Pereira Pedrosa , Renan Serenini , Risia Cristina Egito de Menezes , Giovana Longo-Silva

Objective

To investigate the association of sleep and circadian hygiene practices (sleep-promoting and sleep-disturbing behaviors) with sleep quality indicators.

Methods

Participants (n = 2050; 18–65 y) were part of virtual population-based research. Logistic regression models were fitted to assess differences in the OR (95% CI) of poor quality with sleep-promoting/disturbing practices (time-of-day of exercise, pre-bedtime routine, naps, electronic devices with illuminated screens, caffeine and alcohol consumption, and smoking). Linear regression analyses evaluated differences in sleep duration, latency, and awakenings associated with the same variables. Restricted cubic splines were used to study the shape of the association of screen time before bed with sleep duration, latency, and awakenings. Analyses were adjusted for age, sex, region, marital status, educational level, evening diet quality, and BMI.

Results

Evening use of electronic devices with illuminated screens showed a negative effect on all sleep parameters. Reporting dinner as the largest meal and evening caffeine consumption was associated with shorter sleep duration and longer sleep latency. Smokers had higher odds of longer latency. A protective effect of morning exercises was demonstrated on sleep quality, latency, and awakenings. Alcohol consumers presented lower odds of poor quality and lower frequency of awakenings. Pre-bedtime practices showed no or negative effect on sleep outcomes.

Conclusions

Recommendations to promote sleep quality and prevent sleep-related problems, with corresponding circadian health benefits, should include engaging in regular exercise, preferably in the morning, and avoiding naps, heavy meals close to bedtime, caffeine, smoking, and evening screen exposure.

目的探讨睡眠和昼夜节律卫生习惯(促进睡眠和干扰睡眠行为)与睡眠质量指标的关系。方法参与者(n=2050;18-65岁)是虚拟人群研究的一部分。拟合Logistic回归模型,以评估睡眠促进/干扰行为(一天中的锻炼时间、睡前常规、小睡、带照明屏幕的电子设备、咖啡因和酒精消费以及吸烟)与不良质量的OR(95%CI)的差异。线性回归分析评估了与相同变量相关的睡眠持续时间、潜伏期和觉醒的差异。限制性三次样条用于研究睡前屏幕时间与睡眠时间、潜伏期和觉醒之间的关系。分析根据年龄、性别、地区、婚姻状况、教育水平、晚间饮食质量和BMI进行了调整。结果晚间使用带照明屏幕的电子设备对所有睡眠参数都有负面影响。晚餐是最大的一餐,晚上摄入咖啡因与睡眠时间更短和睡眠延迟更长有关。吸烟者潜伏期延长的几率更高。晨练对睡眠质量、潜伏期和觉醒有保护作用。酒精消费者出现质量差的几率较低,清醒的频率也较低。睡前练习对睡眠结果没有影响或有负面影响。结论提高睡眠质量和预防睡眠相关问题的建议,以及相应的昼夜节律健康益处,应包括定期锻炼,最好是在早上,避免小睡、睡前大量进食、咖啡因、吸烟和晚上接触屏幕。
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引用次数: 1
Sleep disorders after COVID-19 in Czech population: Post-lockdown national online survey 新冠肺炎后捷克人群的睡眠障碍:封锁后全国在线调查。
Q1 Medicine Pub Date : 2023-09-27 DOI: 10.1016/j.sleepx.2023.100087
Tereza Dvořáková , Radana Měrková , Jitka Bušková

Objective

This study aimed to determine the frequency, type, and correlates of a broad spectrum of sleep disorders in adults with COVID-19 up to 32 months after infection.

Methods

We conducted a national online survey (Jun 2021–Dec 2022), gathering information on COVID-19 diagnosis, acute disease course, and the subsequent development of sleep disorders from 1507 respondents (mean age 44.5 ± 13.1 years, 64.1% women).

Results

81.3% (1223) reported at least one sleep difficulty that either worsened or first appeared with COVID-19. Females reported a higher number of symptoms (2.03 ± 1.44 versus 1.72 ± 1.43 in men, p < 0.0001). Most common were insomnia symptoms (59.4%), followed by night sweats (38.4%), hypersomnolence (33.3%), vivid dreams or nightmares (26.4%), restless leg syndrome (RLS) (22.8%), and sleep-related breathing disorders (11.1%). All symptoms were associated with a more severe acute disease. A mild decreasing trend in the persistence of sleep symptoms with a longer latency since infection was observed, with 66.7% reporting at least half of their symptoms present at 3–5 months after acute infection, compared to 64.9% at 6–8 months, and 62.4% at 9–11 months (p = 0.0427). However, among those after 12 or more months, over half of the symptoms persisted in 69.5%. The frequency of vivid dreams and nightmares increased in association with COVID-19 in 32.9% (p < 0.001). 9.4% (141) reported new-onset or increased parasomnic manifestations after the infection.

Conclusions

Our research shows that sleep disturbances are a common and persistent manifestation of COVID-19 that affects a large proportion of the population and deserves careful monitoring.

目的:本研究旨在确定新冠肺炎成人感染后32个月内广泛睡眠障碍的频率、类型和相关性。方法:我们进行了一项全国在线调查(2020年6月至2022年12月),收集了1507名受访者(平均年龄44.5±13.1岁,女性64.1%)的新冠肺炎诊断、急性病程和随后的睡眠障碍发展信息。女性报告的症状数量更高(2.03±1.44,而男性为1.72±1.43,p结论:我们的研究表明,睡眠障碍是新冠肺炎的常见和持续表现,影响了很大一部分人群,值得仔细监测。
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引用次数: 0
期刊
Sleep Medicine: X
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