Sleep Medicine: X最新文献_第4页

The potential impact of habitual sleep quality on glycaemic control and inflammation: A study on geriatric patients recently diagnosed with type 2 diabetes mellitus (T2DM) 习惯性睡眠质量对血糖控制和炎症的潜在影响：新近诊断为2型糖尿病（T2DM）的老年患者的研究

Q1 Medicine

Sleep Medicine: X

Pub Date : 2025-03-07 DOI: 10.1016/j.sleepx.2025.100139

Nadia Hussain , Amal Hussain Ibrahim Al Haddad , Saima Abbass , Zina Alfahl

Sleep quality and its relationship with glycaemic control is of particular interest in the context of geriatric diabetes. We aimed to investigate the potential impact of habitual sleep quality on glycaemic control status among geriatric patients recently diagnosed with type 2 diabetes mellitus (T2DM). A total of 193 geriatric patients recently diagnosed with T2DM in a tertiary-care hospital were selected. A developed questionnaire was used to assess various aspects of sleep quality. Glycaemic control was evaluated through fasting blood glucose levels, HbA1c measurements and number of admissions to the hospital for hypoglycaemic or hyperglycaemic episodes. Patients were divided into Poor Sleep Quality (PSQ, n = 132) and Adequate Sleep Quality (ASQ, n = 61) groups. The PSQ group exhibited significantly worse sleep outcomes, including longer sleep latency (35 ± 9.2 min vs. 15 ± 6.4 min), shorter sleep duration (5 h 42 min vs. 7 h 18 min) and greater use of sleep medications (72 % vs. 22 %). Glycaemic control, measured by HbA1c, was worse in the PSQ group (8.7 ± 1.9 vs. 7.2 ± 1.2; p < 0.01), which also had more frequent severe hypoglycaemic (35 ± 1.4 vs. 8 ± 2.1; p = 0.02) and ketoacidotic episodes (72 ± 1.0 vs. 5 ± 1.1; p = 0.01). These findings suggest an association between poor sleep quality and poorer glycaemic control, with more frequent diabetes-related complications, highlighting the need for further research to explore potential causal relationships and targeted interventions in this population.

睡眠质量及其与血糖控制的关系是在老年糖尿病的背景下特别感兴趣。我们旨在研究习惯性睡眠质量对新近诊断为2型糖尿病（T2DM）的老年患者血糖控制状况的潜在影响。本研究选取了193例新近在三级医院诊断为2型糖尿病的老年患者。一份开发好的问卷用于评估睡眠质量的各个方面。通过空腹血糖水平、糖化血红蛋白（HbA1c）测量和低血糖或高血糖发作入院次数来评估血糖控制。将患者分为睡眠质量差组（PSQ, n = 132）和睡眠质量足组（ASQ, n = 61）。PSQ组表现出明显更差的睡眠结果，包括更长的睡眠潜伏期（35±9.2分钟对15±6.4分钟），更短的睡眠时间（5小时42分钟对7小时18分钟）和更多的睡眠药物使用（72%对22%）。糖化血红蛋白（HbA1c）测量的血糖控制在PSQ组更差(8.7±1.9 vs. 7.2±1.2；p & lt;0.01)，严重低血糖发生率也更高(35±1.4∶8±2.1；P = 0.02)和酮症酸中毒发作(72±1.0∶5±1.1；p = 0.01)。这些发现表明睡眠质量差与血糖控制差之间存在关联，糖尿病相关并发症更频繁，强调需要进一步研究以探索潜在的因果关系和针对这一人群的有针对性的干预措施。

{"title":"The potential impact of habitual sleep quality on glycaemic control and inflammation: A study on geriatric patients recently diagnosed with type 2 diabetes mellitus (T2DM)","authors":"Nadia Hussain , Amal Hussain Ibrahim Al Haddad , Saima Abbass , Zina Alfahl","doi":"10.1016/j.sleepx.2025.100139","DOIUrl":"10.1016/j.sleepx.2025.100139","url":null,"abstract":"<div><div>Sleep quality and its relationship with glycaemic control is of particular interest in the context of geriatric diabetes. We aimed to investigate the potential impact of habitual sleep quality on glycaemic control status among geriatric patients recently diagnosed with type 2 diabetes mellitus (T2DM). A total of 193 geriatric patients recently diagnosed with T2DM in a tertiary-care hospital were selected. A developed questionnaire was used to assess various aspects of sleep quality. Glycaemic control was evaluated through fasting blood glucose levels, HbA1c measurements and number of admissions to the hospital for hypoglycaemic or hyperglycaemic episodes. Patients were divided into Poor Sleep Quality (PSQ, n = 132) and Adequate Sleep Quality (ASQ, n = 61) groups. The PSQ group exhibited significantly worse sleep outcomes, including longer sleep latency (35 ± 9.2 min vs. 15 ± 6.4 min), shorter sleep duration (5 h 42 min vs. 7 h 18 min) and greater use of sleep medications (72 % vs. 22 %). Glycaemic control, measured by HbA1c, was worse in the PSQ group (8.7 ± 1.9 vs. 7.2 ± 1.2; p < 0.01), which also had more frequent severe hypoglycaemic (35 ± 1.4 vs. 8 ± 2.1; p = 0.02) and ketoacidotic episodes (72 ± 1.0 vs. 5 ± 1.1; p = 0.01). These findings suggest an association between poor sleep quality and poorer glycaemic control, with more frequent diabetes-related complications, highlighting the need for further research to explore potential causal relationships and targeted interventions in this population.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"9 ","pages":"Article 100139"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143591634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mind at rest, mind at risk: A prospective population-based study of sleep and subsequent mental disorders 休息时的头脑，处于危险中的头脑：一项基于人群的睡眠和随后的精神障碍的前瞻性研究

Q1 Medicine

Sleep Medicine: X

Pub Date : 2025-01-16 DOI: 10.1016/j.sleepx.2025.100138

Mari Hysing , Allison G. Harvey , Ann Kristin Skrindo Knudsen , Jens C. Skogen , Anne Reneflot , Børge Sivertsen

Background

Depression and anxiety disorders are highly prevalent among young adults, with evidence suggesting sleep problems as key risk factors.

Objective

This study aimed to examine the association between insomnia and sleep characteristics with major depressive episode (MDE) and anxiety disorders, and the association after accounting for baseline mental health symptoms.

Methods

We conducted a prospective cohort study using data from the Students’ Health and Wellbeing Study (SHoT), surveying Norwegian higher education students aged 18 to 35 (N = 53,362). A diagnostic assessment of 10,460 participants was conducted in 2023. Self-reported insomnia, sleep duration, sleep onset latency, and wake after sleep onset were recorded in 2022. MDE and five types of anxiety disorders were assessed after one year using a self-administered CIDI 5.0. Analyses adjusted for age, sex, baseline mental health symptoms, and somatic conditions.

Results

Insomnia in young adults was associated with a significantly increased risk of MDE (adjusted RR = 3.50, 95 % CI = 3.18–3.84) and generalized anxiety disorder (GAD) (adjusted RR = 2.82, 95 % CI = 2.55–3.12) one year later. Sleep duration showed a reversed J-shaped association with mental disorders, with both short and, to a lesser extent, long sleep durations linked to elevated risks, even after adjusting for baseline mental health symptoms and somatic conditions. Although the associations were attenuated after adjustment, they remained statistically significant.

Conclusion

Sleep disturbances, including insomnia and abnormal sleep durations, predict mental health issues in young adults, even after accounting for baseline mental health and somatic health. Addressing sleep problems early may help prevent subsequent mental health conditions in this population.

抑郁症和焦虑症在年轻人中非常普遍，有证据表明睡眠问题是关键的风险因素。目的本研究旨在探讨失眠和睡眠特征与重度抑郁发作（MDE）和焦虑障碍之间的关系，以及在考虑基线心理健康症状后的相关性。方法采用学生健康与幸福研究（SHoT）的数据进行前瞻性队列研究，调查挪威18至35岁的高等教育学生（N = 53,362）。2023年对10460名参与者进行了诊断评估。在2022年记录了自我报告的失眠症、睡眠持续时间、睡眠开始潜伏期和睡眠开始后醒来。一年后使用自我管理的CIDI 5.0对MDE和五种焦虑症进行评估。分析调整了年龄、性别、基线心理健康症状和躯体状况。结果青年睡眠与一年后MDE（校正RR = 3.50, 95% CI = 3.18-3.84）和广泛性焦虑障碍（GAD）（校正RR = 2.82, 95% CI = 2.55-3.12）的风险显著增加相关。睡眠时间与精神障碍呈反j型关系，即使在调整了基线精神健康症状和躯体状况之后，短睡眠时间和较长睡眠时间都与风险增加有关。虽然调整后相关性减弱，但仍具有统计学意义。结论：即使在考虑了基线心理健康和躯体健康后，包括失眠和异常睡眠持续时间在内的睡眠障碍仍可预测年轻人的心理健康问题。尽早解决睡眠问题可能有助于预防这一人群随后出现的精神健康问题。

{"title":"Mind at rest, mind at risk: A prospective population-based study of sleep and subsequent mental disorders","authors":"Mari Hysing , Allison G. Harvey , Ann Kristin Skrindo Knudsen , Jens C. Skogen , Anne Reneflot , Børge Sivertsen","doi":"10.1016/j.sleepx.2025.100138","DOIUrl":"10.1016/j.sleepx.2025.100138","url":null,"abstract":"<div><h3>Background</h3><div>Depression and anxiety disorders are highly prevalent among young adults, with evidence suggesting sleep problems as key risk factors.</div></div><div><h3>Objective</h3><div>This study aimed to examine the association between insomnia and sleep characteristics with major depressive episode (MDE) and anxiety disorders, and the association after accounting for baseline mental health symptoms.</div></div><div><h3>Methods</h3><div>We conducted a prospective cohort study using data from the Students’ Health and Wellbeing Study (SHoT), surveying Norwegian higher education students aged 18 to 35 (N = 53,362). A diagnostic assessment of 10,460 participants was conducted in 2023. Self-reported insomnia, sleep duration, sleep onset latency, and wake after sleep onset were recorded in 2022. MDE and five types of anxiety disorders were assessed after one year using a self-administered CIDI 5.0. Analyses adjusted for age, sex, baseline mental health symptoms, and somatic conditions.</div></div><div><h3>Results</h3><div>Insomnia in young adults was associated with a significantly increased risk of MDE (adjusted RR = 3.50, 95 % CI = 3.18–3.84) and generalized anxiety disorder (GAD) (adjusted RR = 2.82, 95 % CI = 2.55–3.12) one year later. Sleep duration showed a reversed J-shaped association with mental disorders, with both short and, to a lesser extent, long sleep durations linked to elevated risks, even after adjusting for baseline mental health symptoms and somatic conditions. Although the associations were attenuated after adjustment, they remained statistically significant.</div></div><div><h3>Conclusion</h3><div>Sleep disturbances, including insomnia and abnormal sleep durations, predict mental health issues in young adults, even after accounting for baseline mental health and somatic health. Addressing sleep problems early may help prevent subsequent mental health conditions in this population.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"9 ","pages":"Article 100138"},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determinants of variations in sleep patterns across Brazil: Exploring geographic influences 巴西各地睡眠模式差异的决定因素：探索地理影响。

Q1 Medicine

Sleep Medicine: X

Pub Date : 2024-12-20 DOI: 10.1016/j.sleepx.2024.100137

Giovana Longo-Silva , Renan Serenini , Roberto Antunes , Márcia Lima , Anny Pedrosa , Risia Menezes

Objective

To examine the influence of latitude, longitude, sunrise, and daylight, in conjunction with individual and behavioral factors, on sleep duration, wake time, and bedtime in a country with the world's broadest latitude range, yet characterized by homogeneity in language, cultural traits, and consistent time zones.

Methods

Participants (n = 1440; 18-65y) were part of a virtual population-based survey (2021–22). Sleep patterns were spatially represented through maps using Multilevel B-spline Interpolation. Relationships between and within biological/personal/socio-economic, behavioral and environment characteristics, and sleep outcomes were examined by Lasso regression. Restricted cubic splines were employed to examine the shape of the association of latitude and sunrise with sleep variables and of screen time before bed with bedtime.

Results

Latitude emerged as the primary geographic factor influencing variations in sleep duration and wake time, shortening and advancing, respectively, as latitude increased (towards equatorial line). Younger individuals, those living without partners, with depression, engaging in more frequent evening alcohol consumption, and with poorer diet quality, tended to wake up later. All the variables influenced bedtime, with daylight emerging as the environmental factor exerting the strongest association. While the variability in bedtime showed a non-linear association with latitude and sunrise, it displayed a dose-response relationship with screen time before bed.

Conclusions

Given that adults living in the same country, potentially with a similar timetable, could be having shorter sleep durations according to their latitude position, further studies are required to contemplate advocating for policies that implement schedules based on the sun position rather than the national time zone.

目的：研究纬度、经度、日出和日光，结合个人和行为因素，对世界上纬度范围最广的国家的睡眠时间、起床时间和就寝时间的影响，但其特点是语言、文化特征和时区一致。方法：参与者(n = 1440；18-65岁)是虚拟人口调查（2021- 2022）的一部分。睡眠模式通过多水平b样条插值在空间上表示。生物/个人/社会经济、行为和环境特征与睡眠结果之间和内部的关系通过Lasso回归进行了检验。限制三次样条被用来检验纬度和日出与睡眠变量以及睡前屏幕时间与就寝时间的关系。结果：纬度是影响睡眠时间和清醒时间变化的主要地理因素，随着纬度的增加（向赤道线方向），睡眠时间和清醒时间分别缩短和延长。年轻人，那些没有伴侣、患有抑郁症、晚上经常喝酒、饮食质量较差的人，往往醒得更晚。所有的变量都会影响睡眠时间，其中日光作为环境因素发挥了最强的关联。虽然就寝时间的变化与纬度和日出呈非线性关系，但它与睡前看屏幕的时间呈剂量反应关系。结论：考虑到生活在同一个国家的成年人，可能有着相似的时间表，根据他们的纬度位置，他们的睡眠时间可能会更短，需要进一步的研究来考虑倡导基于太阳位置而不是国家时区实施时间表的政策。

{"title":"Determinants of variations in sleep patterns across Brazil: Exploring geographic influences","authors":"Giovana Longo-Silva , Renan Serenini , Roberto Antunes , Márcia Lima , Anny Pedrosa , Risia Menezes","doi":"10.1016/j.sleepx.2024.100137","DOIUrl":"10.1016/j.sleepx.2024.100137","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the influence of latitude, longitude, sunrise, and daylight, in conjunction with individual and behavioral factors, on sleep duration, wake time, and bedtime in a country with the world's broadest latitude range, yet characterized by homogeneity in language, cultural traits, and consistent time zones.</div></div><div><h3>Methods</h3><div>Participants (n = 1440; 18-65y) were part of a virtual population-based survey (2021–22). Sleep patterns were spatially represented through maps using Multilevel B-spline Interpolation. Relationships between and within biological/personal/socio-economic, behavioral and environment characteristics, and sleep outcomes were examined by Lasso regression. Restricted cubic splines were employed to examine the shape of the association of latitude and sunrise with sleep variables and of screen time before bed with bedtime.</div></div><div><h3>Results</h3><div>Latitude emerged as the primary geographic factor influencing variations in sleep duration and wake time, shortening and advancing, respectively, as latitude increased (towards equatorial line). Younger individuals, those living without partners, with depression, engaging in more frequent evening alcohol consumption, and with poorer diet quality, tended to wake up later. All the variables influenced bedtime, with daylight emerging as the environmental factor exerting the strongest association. While the variability in bedtime showed a non-linear association with latitude and sunrise, it displayed a dose-response relationship with screen time before bed.</div></div><div><h3>Conclusions</h3><div>Given that adults living in the same country, potentially with a similar timetable, could be having shorter sleep durations according to their latitude position, further studies are required to contemplate advocating for policies that implement schedules based on the sun position rather than the national time zone.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"9 ","pages":"Article 100137"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative efficacy of sodium oxybate versus placebo on improvement of nighttime sleep in adult patients with narcolepsy: A systematic review and meta-analysis 羟苯甲酸钠与安慰剂在改善成年嗜睡症患者夜间睡眠方面的疗效比较：系统回顾和荟萃分析。

Q1 Medicine

Sleep Medicine: X

Pub Date : 2024-12-19 DOI: 10.1016/j.sleepx.2024.100136

Adina Arshad , Muhammad Abdul Muqtadir Qureshi , Muhammad Abdullah Masood , Hafiz Shahbaz Zahoor , Ayesha Nazakat , Anfal Fatima , Javed Iqbal

Background

Narcolepsy, a central hypersomnolence disorder, disrupts sleep regulation. Sodium oxybate, a CNS (central nervous system) depressant, is widely used as a treatment, but there are surprisingly very few rigorous studies comparing its effectiveness to placebo in adults.

Objectives

To measure the comparative efficacy of sodium oxybate at a dosage regimen of 9 g versus placebo in improving nighttime sleep quality, reducing nocturnal arousals and sleep stage shifts, and enhancing the overall refreshed nature of sleep in adult patients with narcolepsy.

Methods

The methodology included a literature review of PubMed, Cochrane, Scopus, Google Scholar, and Clinicaltrials.gov, retrieving 53 randomized controlled trials (RCT) after removing 14 duplicates. Four studies met the criteria for gauging the efficacy of sodium oxybate compared to placebo in the adult population with narcolepsy. The primary efficacy outcome was improved sleep quality, whereas secondary outcomes were reduced nocturnal arousals and sleep stage shifts with an overall refreshed sleep nature. Analyses used RevMan 5.3 software, and SMD (standardized mean differences) with 95 % CI (confidence intervals) were calculated. Risk and publication biases were measured with Cochrane risk of bias tools and Comprehensive Meta-Analysis Software. Evidence certainty was measured using GRADEpro.

Results

Four RCT involving 1079 participants were analyzed for said outcomes, and relevant forest plots were generated. Statistical analysis showed a substantial improvement in sleep quality [SMD = 0.74(95%Cl:0.53,0.95; p < 0.00001; I² = 0 %; (high certainty)] and refreshing nature of sleep [SMD = 0.81(95%CI:0.51,1.11; P < 0.00001; I² = 0 %; (moderate certainty)], reduction in nocturnal arousals [SMD = −0.62(95%CI: 0.92,-0.32; p < 0.00001; I² = 0 %; (moderate certainty)] and sleep stage shifts [SMD = −1.22(95%CI: 1.46,-0.98; p < 0.00001; I² = 0 %; (high certainty)]. The risk of bias was located high for one study. Symmetrical funnel plots and Egger's regression intercepts testified to no significant publication bias.

Conclusions

The results showed that sodium oxybate considerably improved the quality of nocturnal sleep, resulting in substantial restorative advantages as well as a decrease in nocturnal arousals and sleep stage transitions. Significant results with low heterogeneity and p-values <0.05, showing consistent effects, were obtained from the analysis. However, overall reliability may be impacted by a high risk of bias in one study.

背景：嗜睡症是一种中枢性嗜睡障碍，破坏睡眠调节。氧酸钠是一种中枢神经系统抑制剂，被广泛用于治疗，但令人惊讶的是，很少有严谨的研究将其与安慰剂在成人中的效果进行比较。目的：比较9g剂量方案下的氧酸钠与安慰剂在改善成人发作性睡病患者夜间睡眠质量、减少夜间觉醒和睡眠阶段变化、增强整体睡眠精神状态方面的疗效。方法：纳入PubMed、Cochrane、Scopus、谷歌Scholar和Clinicaltrials.gov的文献综述，剔除14项重复，检索53项随机对照试验（RCT）。有四项研究符合衡量氧酸钠与安慰剂在成人嗜睡症患者中的疗效的标准。主要的疗效结果是改善睡眠质量，而次要的结果是减少夜间觉醒和睡眠阶段的变化，整体刷新睡眠性质。采用RevMan 5.3软件进行分析，计算SMD（标准化平均差异），95% CI（置信区间）。使用Cochrane风险偏倚工具和综合meta分析软件测量风险偏倚和发表偏倚。使用GRADEpro测量证据确定性。结果：对4项随机对照试验1079名受试者进行了上述结果分析，并生成了相关的森林样地。统计分析显示睡眠质量有明显改善[SMD = 0.74(95%Cl:0.53,0.95；p 2 = 0%；（高确定性）]和睡眠的清爽性[SMD = 0.81(95%CI:0.51,1.11；p 2 = 0%；（中度肯定）]，夜间觉醒减少[SMD = -0.62(95%CI: 0.92,-0.32；p 2 = 0%；（中等确定性）]和睡眠阶段变化[SMD = -1.22(95%CI: 1.46,-0.98；p 2 = 0%；(高确定性)]。有一项研究的偏倚风险很高。对称漏斗图和Egger的回归截距证明没有显著的发表偏倚。结论：结果表明，氧化钠能显著改善夜间睡眠质量，具有明显的恢复性优势，并能减少夜间觉醒和睡眠阶段转换。具有低异质性和p值的显著结果

{"title":"Comparative efficacy of sodium oxybate versus placebo on improvement of nighttime sleep in adult patients with narcolepsy: A systematic review and meta-analysis","authors":"Adina Arshad , Muhammad Abdul Muqtadir Qureshi , Muhammad Abdullah Masood , Hafiz Shahbaz Zahoor , Ayesha Nazakat , Anfal Fatima , Javed Iqbal","doi":"10.1016/j.sleepx.2024.100136","DOIUrl":"10.1016/j.sleepx.2024.100136","url":null,"abstract":"<div><h3>Background</h3><div>Narcolepsy, a central hypersomnolence disorder, disrupts sleep regulation. Sodium oxybate, a CNS (central nervous system) depressant, is widely used as a treatment, but there are surprisingly very few rigorous studies comparing its effectiveness to placebo in adults.</div></div><div><h3>Objectives</h3><div>To measure the comparative efficacy of sodium oxybate at a dosage regimen of 9 g versus placebo in improving nighttime sleep quality, reducing nocturnal arousals and sleep stage shifts, and enhancing the overall refreshed nature of sleep in adult patients with narcolepsy.</div></div><div><h3>Methods</h3><div>The methodology included a literature review of PubMed, Cochrane, Scopus, Google Scholar, and Clinicaltrials.gov, retrieving 53 randomized controlled trials (RCT) after removing 14 duplicates. Four studies met the criteria for gauging the efficacy of sodium oxybate compared to placebo in the adult population with narcolepsy. The primary efficacy outcome was improved sleep quality, whereas secondary outcomes were reduced nocturnal arousals and sleep stage shifts with an overall refreshed sleep nature. Analyses used RevMan 5.3 software, and SMD (standardized mean differences) with 95 % CI (confidence intervals) were calculated. Risk and publication biases were measured with Cochrane risk of bias tools and Comprehensive Meta-Analysis Software. Evidence certainty was measured using GRADEpro.</div></div><div><h3>Results</h3><div>Four RCT involving 1079 participants were analyzed for said outcomes, and relevant forest plots were generated. Statistical analysis showed a substantial improvement in sleep quality [SMD = 0.74(95%Cl:0.53,0.95; p < 0.00001; I<sup>2</sup> = 0 %; (high certainty)] and refreshing nature of sleep [SMD = 0.81(95%CI:0.51,1.11; P < 0.00001; I<sup>2</sup> = 0 %; (moderate certainty)], reduction in nocturnal arousals [SMD = −0.62(95%CI: 0.92,-0.32; p < 0.00001; I<sup>2</sup> = 0 %; (moderate certainty)] and sleep stage shifts [SMD = −1.22(95%CI: 1.46,-0.98; p < 0.00001; I<sup>2</sup> = 0 %; (high certainty)]. The risk of bias was located high for one study. Symmetrical funnel plots and Egger's regression intercepts testified to no significant publication bias.</div></div><div><h3>Conclusions</h3><div>The results showed that sodium oxybate considerably improved the quality of nocturnal sleep, resulting in substantial restorative advantages as well as a decrease in nocturnal arousals and sleep stage transitions. Significant results with low heterogeneity and p-values <0.05, showing consistent effects, were obtained from the analysis. However, overall reliability may be impacted by a high risk of bias in one study.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"9 ","pages":"Article 100136"},"PeriodicalIF":0.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11728066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to “Sleep body position correlates with cognitive performance in middle-old obstructive sleep apnea subjects” [Sleep Med: X 4 (2022) 100050] “睡眠体位与中老年阻塞性睡眠呼吸暂停受试者认知表现的相关性”的勘误[睡眠医学：X 4 (2022) 100050]

Q1 Medicine

Sleep Medicine: X

Pub Date : 2024-12-15 DOI: 10.1016/j.sleepx.2024.100131

Sara Girolami, Marta Tardio, Serpetti Loredana, Nadia Di Mattia, Pamela Micheletti, Mario Di Napoli

引用次数: 0

Erratum to “The importance of sleep studies in improving the health indices of a nation” [Sleep Med: X 4 (2022) 100049] “睡眠研究对提高国民健康指数的重要性”的勘误[睡眠医学：X 4 (2022) 100049]

Q1 Medicine

Sleep Medicine: X

Pub Date : 2024-12-15 DOI: 10.1016/j.sleepx.2024.100130

Jitendra Kumar Sinha , Kshitij Vashisth , Shampa Ghosh

引用次数: 0

Erratum to “Association of food intake with sleep disorders in children and adolescents with obesity” [Sleep Med: X 4 (2022) 100053] “肥胖儿童和青少年食物摄入与睡眠障碍的关系”的勘误[睡眠医学：X 4 (2022) 100053]

Q1 Medicine

Sleep Medicine: X

Pub Date : 2024-12-15 DOI: 10.1016/j.sleepx.2024.100132

Raquel S.M. Zarpellon , Dra Regina M. Vilela , Fernando Mazzilli Louzada , Dra Rosana B. Radominski , Dra Ana Chrystina de Souza Crippa

引用次数: 0

Insomnia, cardiorespiratory function and quality of life in individuals with post-COVID-19 fatigue covid -19后疲劳患者的失眠、心肺功能和生活质量

Q1 Medicine

Sleep Medicine: X

Pub Date : 2024-11-27 DOI: 10.1016/j.sleepx.2024.100135

Nathalea Spode de Arruda , Alessandra Hofstadler Deiques Fleig , Charles Rech , Carine Cristina Callegaro

Objective

This study aimed to compare the prevalence of insomnia, lung function, inspiratory muscle function, functional capacity, and quality of life in individuals with and without post-COVID-19 fatigue.

Methods

Thirty-four post-COVID-19 individuals participated in the study, 20 with fatigue (32 ± 12 years old, 15% male) and 14 without fatigue (31 ± 12 years old, 42.9% male). The Chalder Fatigue Scale (CFS) was employed to categorize the volunteers into two groups: those with fatigue (score ≥4) and those without fatigue (score <4). The Insomnia Severity Index (ISI) and the Epworth Sleepiness Scale (ESS) were used to assess insomnia and excessive daytime sleepiness, respectively. Pulmonary function was evaluated by spirometry, inspiratory muscle strength was assessed by the maximum inspiratory pressure (MIP), and inspiratory endurance was evaluated by maintaining an inspiratory load of 60% of MIP until fatigue. The 6-min walk test (6MWT) was used to evaluated functional capacity, while the WHOQOL-BREF questionnaire assessed quality of life.

Results

Individuals with post-COVID-19 fatigue demonstrated a higher prevalence of insomnia (80% vs. 49%) and excessive daytime sleepiness (45% vs. 7%), as well as lower MIP, shorter distance covered in the 6MWT, and lower FEV₁/FVC (forced expired volume in the first second divided by forced vital capacity), and FEV₁/FVC% of predicted. Additionally, they exhibited poorer quality of life in the physical and environmental domains. CFS demonstrated a direct correlation with ISI (r=0.436, p=0.01) and ESS (r=0.593, p=0.001), as well as an inverse correlation with the distance covered in the 6MWT (r=-0.398, p=0.022) and FEV₁ (r=-0.412, p=0.01). ISI was an independent predictor of CFS, with 62% of CFS variance explained by ISI variance.

Conclusion

Individuals with symptoms of post-COVID-19 fatigue may have a higher prevalence of insomnia, reduced inspiratory muscle strength, functional capacity, and Tiffeneau index, along with impaired quality of life. ISI is an independent predictor of post-COVID-19 fatigue.

目的比较covid -19后疲劳患者和非患者的失眠患病率、肺功能、吸气肌功能、功能容量和生活质量。方法34例新冠肺炎后患者参与研究，其中疲劳20例（年龄32±12岁，男性15%），无疲劳14例（年龄31±12岁，男性42.9%）。采用Chalder疲劳量表（CFS）将志愿者分为疲劳组（评分≥4分）和非疲劳组（评分<；4分）。失眠严重程度指数（ISI）和Epworth嗜睡量表（ESS）分别用于评估失眠和日间过度嗜睡。通过肺活量测定法评估肺功能，通过最大吸气压力（MIP）评估吸气肌力量，通过保持60% MIP的吸气负荷直到疲劳来评估吸气耐力。采用6分钟步行测试（6MWT）评估功能能力，采用WHOQOL-BREF问卷评估生活质量。结果covid -19后疲劳患者表现出更高的失眠率（80%对49%）和日间过度嗜睡（45%对7%），MIP较低，6MWT覆盖距离较短，FEV1/FVC（第一秒强制呼气体积除以强制肺活量）较低，FEV1/FVC为预测值的%。此外，他们在物理和环境领域表现出较差的生活质量。CFS与ISI （r=0.436, p=0.01）、ESS （r=0.593, p=0.001）呈正相关，与6MWT覆盖距离（r=-0.398, p=0.022）、FEV1 （r=-0.412, p=0.01）呈负相关。ISI是CFS的独立预测因子，62%的CFS方差可由ISI方差解释。结论出现新冠肺炎后疲劳症状的个体失眠发生率较高，吸气肌力量、功能能力和蒂菲诺指数下降，生活质量下降。ISI是covid -19后疲劳的独立预测因子。

{"title":"Insomnia, cardiorespiratory function and quality of life in individuals with post-COVID-19 fatigue","authors":"Nathalea Spode de Arruda , Alessandra Hofstadler Deiques Fleig , Charles Rech , Carine Cristina Callegaro","doi":"10.1016/j.sleepx.2024.100135","DOIUrl":"10.1016/j.sleepx.2024.100135","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to compare the prevalence of insomnia, lung function, inspiratory muscle function, functional capacity, and quality of life in individuals with and without post-COVID-19 fatigue.</div></div><div><h3>Methods</h3><div>Thirty-four post-COVID-19 individuals participated in the study, 20 with fatigue (32 ± 12 years old, 15% male) and 14 without fatigue (31 ± 12 years old, 42.9% male). The Chalder Fatigue Scale (CFS) was employed to categorize the volunteers into two groups: those with fatigue (score ≥4) and those without fatigue (score <4). The Insomnia Severity Index (ISI) and the Epworth Sleepiness Scale (ESS) were used to assess insomnia and excessive daytime sleepiness, respectively. Pulmonary function was evaluated by spirometry, inspiratory muscle strength was assessed by the maximum inspiratory pressure (MIP), and inspiratory endurance was evaluated by maintaining an inspiratory load of 60% of MIP until fatigue. The 6-min walk test (6MWT) was used to evaluated functional capacity, while the WHOQOL-BREF questionnaire assessed quality of life.</div></div><div><h3>Results</h3><div>Individuals with post-COVID-19 fatigue demonstrated a higher prevalence of insomnia (80% vs. 49%) and excessive daytime sleepiness (45% vs. 7%), as well as lower MIP, shorter distance covered in the 6MWT, and lower FEV<sub>1</sub>/FVC (forced expired volume in the first second divided by forced vital capacity), and FEV<sub>1</sub>/FVC% of predicted. Additionally, they exhibited poorer quality of life in the physical and environmental domains. CFS demonstrated a direct correlation with ISI (r=0.436, p=0.01) and ESS (r=0.593, p=0.001), as well as an inverse correlation with the distance covered in the 6MWT (r=-0.398, p=0.022) and FEV<sub>1</sub> (r=-0.412, p=0.01). ISI was an independent predictor of CFS, with 62% of CFS variance explained by ISI variance.</div></div><div><h3>Conclusion</h3><div>Individuals with symptoms of post-COVID-19 fatigue may have a higher prevalence of insomnia, reduced inspiratory muscle strength, functional capacity, and Tiffeneau index, along with impaired quality of life. ISI is an independent predictor of post-COVID-19 fatigue.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"9 ","pages":"Article 100135"},"PeriodicalIF":0.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Poor sleep quality among bedtime smartphone user medical students in Ethiopia, 2024 埃塞俄比亚睡前使用智能手机的医学生睡眠质量差，2024 年

Q1 Medicine

Sleep Medicine: X

Pub Date : 2024-11-22 DOI: 10.1016/j.sleepx.2024.100134

Dereje Esubalew , Amare Mebrat Delie , Liknaw Workie Limenh , Nigus Kassie Worku , Eneyew Talie Fenta , Mickiale Hailu , Alemwork Abie , Molla Getie Mehari , Tenagnework Eseyneh Dagnaw , Mihret Melese

Background

Smartphone use has become widespread and continues to grow rapidly. Medical students, already highly susceptible to sleep deprivation, may experience exacerbated issues due to smartphone usage, particularly at bedtime. Therefore, understanding the potential negative impacts of this behavior is crucial. This study aims to assess the prevalence and risk factors of sleep quality among medical students bed time smart phone users in Ethiopia.

Subject and methods

An institutional-based cross-sectional study design was employed, involving 354 undergraduate medical students selected through simple random sampling from Debre Marko's University, the University of Gondar, and Debre Berhan University. Data were collected using the Pittsburgh Sleep Quality Index and structured interviews. Variables with a p-value of ≤0.2 in bivariable regression were included in multivariable logistic regression. Crude odds ratios and adjusted odds ratios were calculated, while chi-square tests were used to assess assumptions. In multivariable regression, variables with a p-value of ≤0.05 were deemed significant predictors at the 95 % confidence interval.

Result

The results showed that among bedtime smartphone users, 67.52 % had a poor sleep quality index greater than 5. Poor sleep quality was significantly linked to factors such as sex, regular coffee consumption, the purpose of smartphone use, phone position during use, the duration of smartphone use, and a history of disease. Social media usage was the most common activity, accounting for 41.60 % of smartphone use, followed by watching videos (21.65 %).

Conclusion

This study highlights the detrimental effects of bedtime smartphone use on sleep quality, which subsequently impacts mental. Given these findings, it is strongly recommended that medical students reduce their smartphone use before bedtime to improve their sleep quality.

背景智能手机的使用已经变得非常普遍，而且还在继续快速增长。医学生本来就很容易睡眠不足，使用智能手机（尤其是在睡前使用）可能会加剧他们的睡眠问题。因此，了解这种行为的潜在负面影响至关重要。本研究旨在评估埃塞俄比亚医科学生睡前使用智能手机的普遍程度和睡眠质量的风险因素。研究对象和方法采用基于院校的横断面研究设计，通过简单随机抽样从德布雷马尔科大学、贡德尔大学和德布雷贝汉大学选取了354名本科医科学生。采用匹兹堡睡眠质量指数和结构化访谈收集数据。在二变量回归中P值≤0.2的变量被纳入多变量逻辑回归。计算粗略的几率比例和调整后的几率比例，同时使用卡方检验来评估假设。结果结果显示，在睡前使用智能手机的人群中，67.52%的人睡眠质量差指数大于5。睡眠质量差与性别、经常喝咖啡、使用智能手机的目的、使用手机时的姿势、使用智能手机的时间长短以及疾病史等因素有明显关系。社交媒体使用是最常见的活动，占智能手机使用量的 41.60%，其次是观看视频（21.65%）。鉴于这些发现，强烈建议医学生减少睡前使用智能手机，以提高睡眠质量。

{"title":"Poor sleep quality among bedtime smartphone user medical students in Ethiopia, 2024","authors":"Dereje Esubalew , Amare Mebrat Delie , Liknaw Workie Limenh , Nigus Kassie Worku , Eneyew Talie Fenta , Mickiale Hailu , Alemwork Abie , Molla Getie Mehari , Tenagnework Eseyneh Dagnaw , Mihret Melese","doi":"10.1016/j.sleepx.2024.100134","DOIUrl":"10.1016/j.sleepx.2024.100134","url":null,"abstract":"<div><h3>Background</h3><div>Smartphone use has become widespread and continues to grow rapidly. Medical students, already highly susceptible to sleep deprivation, may experience exacerbated issues due to smartphone usage, particularly at bedtime. Therefore, understanding the potential negative impacts of this behavior is crucial. This study aims to assess the prevalence and risk factors of sleep quality among medical students bed time smart phone users in Ethiopia.</div></div><div><h3>Subject and methods</h3><div>An institutional-based cross-sectional study design was employed, involving 354 undergraduate medical students selected through simple random sampling from Debre Marko's University, the University of Gondar, and Debre Berhan University. Data were collected using the Pittsburgh Sleep Quality Index and structured interviews. Variables with a p-value of ≤0.2 in bivariable regression were included in multivariable logistic regression. Crude odds ratios and adjusted odds ratios were calculated, while chi-square tests were used to assess assumptions. In multivariable regression, variables with a p-value of ≤0.05 were deemed significant predictors at the 95 % confidence interval.</div></div><div><h3>Result</h3><div>The results showed that among bedtime smartphone users, 67.52 % had a poor sleep quality index greater than 5. Poor sleep quality was significantly linked to factors such as sex, regular coffee consumption, the purpose of smartphone use, phone position during use, the duration of smartphone use, and a history of disease. Social media usage was the most common activity, accounting for 41.60 % of smartphone use, followed by watching videos (21.65 %).</div></div><div><h3>Conclusion</h3><div>This study highlights the detrimental effects of bedtime smartphone use on sleep quality, which subsequently impacts mental. Given these findings, it is strongly recommended that medical students reduce their smartphone use before bedtime to improve their sleep quality.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"8 ","pages":"Article 100134"},"PeriodicalIF":0.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142721558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep quality and associated factors in adults living in the southern Brazil: A population-based study 巴西南部成年人的睡眠质量及相关因素：一项基于人口的研究

Q1 Medicine

Sleep Medicine: X

Pub Date : 2024-11-03 DOI: 10.1016/j.sleepx.2024.100133

Ernani Tiaraju de Santa Helena , Nicolas Boeira Machado , Rafael Tadao Sakae , Clovis Arlindo de Sousa , Carlos Roberto de Oliveira Nunes , Henry Völzke , Ralf Ewert , Marcello Ricardo Paulista Markus

Objective

To analyze sleep quality and associated socio-demographic and lifestyle factors in participants from a city originally colonised by Germans in southern Brazil.

Methods

A cross-sectional population-based study of 2333 individuals aged 20 to 79 years. Data was collected by interview using a structured questionnaire. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. The prevalence of poor sleep quality (PSQI score five or more) was estimated and the associations with study variables were measured by crude and adjusted prevalence ratios using Poisson regression.

Results

participants were mostly women (50.9 %), with an average age of 43.3 years. The median total PSQI score was 4 (IQ = 3-7). The frequency of poor sleep quality was 32.7 % (95 % CI 30.7-34.4), higher in older adults (44.0 % vs 30.7 %; p<0.001) and women (40.0 % vs 25.2 %; p<0.001). Multivariate analysis showed that women (PR = 1.3; 95%CI 1.1- 1.5; p<0.001), former smokers (PR = 1.2; 95%CI 1.0-1.4; p = 0.014), current smokers (PR = 1.3; 95%CI 1.1-1.5; p = 0.006), depression (PR = 1.5; 95%CI 1.3-1.7; p<0.001), taking 5 or more medications (PR = 1.2; 95%CI 1.1-1.4; p = 0.001), self-perceived fair health (PR = 2.1; 95%CI 1.8-2.4; p<0.001) or poor/very poor health (PR = 2.6; 95%CI 2.1-3.1; p<0.001) were risk factors for poor sleep quality. Germanic culture (PR = 0.8; 95%CI 0.7-0.9; p<0.001), high school (PR = 0.8; 95%CI 0.6–1.0; p = 0.046) or elementary school (PR = 0.7; 95%CI 0.6-1.0; p = 0.025) or being at work (RP = 0.8; 95%CI 0.7-0.9; p = 0.002) were inversely associated with poor sleep quality.

Conclusions

Women, older adults and some clinical, social, cultural and behavioural conditions are associated with poor sleep quality.

目标分析巴西南部一个最初由德国人殖民的城市的参与者的睡眠质量以及相关的社会人口和生活方式因素。方法对 2333 名年龄在 20 岁至 79 岁之间的人进行横断面人群研究。数据通过结构化问卷调查收集。睡眠质量采用匹兹堡睡眠质量指数（PSQI）问卷进行评估。我们估算了睡眠质量差（PSQI 得分为 5 分或 5 分以上）的患病率，并使用泊松回归法通过粗略患病率比和调整患病率比测量了睡眠质量差与研究变量之间的关联。PSQI 总分的中位数为 4（IQ = 3-7）。睡眠质量差的发生率为 32.7%（95% CI 30.7-34.4），老年人（44.0% vs 30.7%；p<0.001）和女性（40.0% vs 25.2%；p<0.001）的发生率更高。多变量分析显示，女性（PR = 1.3; 95%CI 1.1- 1.5; p<0.001）、曾经吸烟者（PR = 1.2; 95%CI 1.0-1.4; p = 0.014）、目前吸烟者（PR = 1.3; 95%CI 1.1-1.5; p = 0.006）、抑郁症患者（PR = 1.5; 95%CI 1.3-1.7; p<0.001）、服用 5 种或更多药物（PR = 1.2；95%CI 1.1-1.4；p = 0.001）、自我感觉健康状况一般（PR = 2.1；95%CI 1.8-2.4；p<0.001）或健康状况差/非常差（PR = 2.6；95%CI 2.1-3.1；p<0.001）是睡眠质量差的风险因素。日耳曼文化（PR = 0.8；95%CI 0.7-0.9；p<0.001）、高中（PR = 0.8；95%CI 0.6-1.0；p = 0.046）或小学（PR = 0.7；95%CI 0.6-1.0；p = 0.025）或正在工作（RP = 0.8；95%CI 0.结论女性、老年人以及一些临床、社会、文化和行为状况与睡眠质量差有关。

{"title":"Sleep quality and associated factors in adults living in the southern Brazil: A population-based study","authors":"Ernani Tiaraju de Santa Helena , Nicolas Boeira Machado , Rafael Tadao Sakae , Clovis Arlindo de Sousa , Carlos Roberto de Oliveira Nunes , Henry Völzke , Ralf Ewert , Marcello Ricardo Paulista Markus","doi":"10.1016/j.sleepx.2024.100133","DOIUrl":"10.1016/j.sleepx.2024.100133","url":null,"abstract":"<div><h3>Objective</h3><div>To analyze sleep quality and associated socio-demographic and lifestyle factors in participants from a city originally colonised by Germans in southern Brazil.</div></div><div><h3>Methods</h3><div>A cross-sectional population-based study of 2333 individuals aged 20 to 79 years. Data was collected by interview using a structured questionnaire. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. The prevalence of poor sleep quality (PSQI score five or more) was estimated and the associations with study variables were measured by crude and adjusted prevalence ratios using Poisson regression.</div></div><div><h3>Results</h3><div>participants were mostly women (50.9 %), with an average age of 43.3 years. The median total PSQI score was 4 (IQ = 3-7). The frequency of poor sleep quality was 32.7 % (95 % CI 30.7-34.4), higher in older adults (44.0 % vs 30.7 %; p<0.001) and women (40.0 % vs 25.2 %; p<0.001). Multivariate analysis showed that women (PR = 1.3; 95%CI 1.1- 1.5; p<0.001), former smokers (PR = 1.2; 95%CI 1.0-1.4; p = 0.014), current smokers (PR = 1.3; 95%CI 1.1-1.5; p = 0.006), depression (PR = 1.5; 95%CI 1.3-1.7; p<0.001), taking 5 or more medications (PR = 1.2; 95%CI 1.1-1.4; p = 0.001), self-perceived fair health (PR = 2.1; 95%CI 1.8-2.4; p<0.001) or poor/very poor health (PR = 2.6; 95%CI 2.1-3.1; p<0.001) were risk factors for poor sleep quality. Germanic culture (PR = 0.8; 95%CI 0.7-0.9; p<0.001), high school (PR = 0.8; 95%CI 0.6–1.0; p = 0.046) or elementary school (PR = 0.7; 95%CI 0.6-1.0; p = 0.025) or being at work (RP = 0.8; 95%CI 0.7-0.9; p = 0.002) were inversely associated with poor sleep quality.</div></div><div><h3>Conclusions</h3><div>Women, older adults and some clinical, social, cultural and behavioural conditions are associated with poor sleep quality.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"8 ","pages":"Article 100133"},"PeriodicalIF":0.0,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142651715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0