European Journal of Obstetrics and Gynecology and Reproductive Biology: X最新文献

{"title":"Curcumin, a bioactive supplement for premenstrual syndrome and dysmenorrhea: A systematic review of randomised clinical trials","authors":"Oadi N. Shrateh ,&nbsp;Areesha Jawed ,&nbsp;Muhammad Hamza Shuja ,&nbsp;Kanwal Ashok Kumar ,&nbsp;Syeda Tayyaba Rehan ,&nbsp;Sondos Abdelrhman ,&nbsp;Mashhour Naasan ,&nbsp;Nor Azlia Abdul Wahab","doi":"10.1016/j.eurox.2025.100432","DOIUrl":"10.1016/j.eurox.2025.100432","url":null,"abstract":"<div><h3>Introduction</h3><div>The anti-inflammatory nature of curcumin suggests its potential to modulate the body's inflammatory processes, offering a novel avenue for mitigating heightened inflammatory responses often observed in conditions like PMS and dysmenorrhea.</div></div><div><h3>Methods</h3><div>MEDLINE, Cochrane Central, ScienceDirect, Web of Science, CINAHL, ClinicalTrials.gov, and Google Scholar from their inception to November 12, 2023. The review was conducted according to the Cochrane Handbook for Systematic Reviews of Interventions. The outcomes of interest encompassed evaluating the severity of PMS symptoms and dysmenorrhea, including physical symptoms, behavioral symptoms, mood symptoms. Additionally, the study focused on assessing inflammatory biomarkers, Iron profile and Vitamin D status as other outcomes.</div></div><div><h3>Results</h3><div>Ten randomized controlled trials have evaluated the effectiveness of curcumin in reducing premenstrual syndrome and dysmenorrhea symptoms in women. These studies used various scales such as the Premenstrual Syndrome Screening Tool (PSST) and visual analog scale. Out of ten trials, six of them reported a significant decrease in PMS and dysmenorrhea symptoms. Additionally, six studies evaluated curcumin's association with inflammatory markers, hematological parameters, iron profile, Vitamin D, and sleep patterns. This demonstrated significant association between curcumin and inflammatory markers (nitric oxide metabolites, BDNF, IgE, Il-10, IL-12, hs-CRP), and vitamin D status.</div></div><div><h3>Conclusion</h3><div>The findings of this systematic review suggest that curcumin holds promise in the management of PMS and dysmenorrhea. However, further research is needed to establish optimal dosages and treatment durations, considering potential interactions with iron metabolism. The results encourage the exploration of curcumin as a complementary approach in enhancing the overall well-being of individuals affected by these menstrual conditions.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"28 ","pages":"Article 100432"},"PeriodicalIF":1.7,"publicationDate":"2025-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145466710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to evidence-based intrapartum care practices and influencing factors among obstetric care providers in Ethiopia: A systematic review and meta-analysis","authors":"Gemeda Wakgari Kitil ,&nbsp;Abiy Tasew Dubale","doi":"10.1016/j.eurox.2025.100431","DOIUrl":"10.1016/j.eurox.2025.100431","url":null,"abstract":"<div><h3>Background</h3><div>Globally standardized evidence-based intrapartum care practices are essential for enhancing health outcomes for mothers and newborns. Despite recent advancements, Ethiopia grapples with significant challenges in maternal healthcare, with the implementation of evidence-based intrapartum practices falling below recognized standards. To address this gap, our systematic review and meta-analysis investigate existing literature to unveil the current state of evidence-based intrapartum care practices and identify contributing factors in Ethiopia.</div></div><div><h3>Methods</h3><div>This study focused on Ethiopian research and adhered to the PRISMA checklist. Thirteen relevant studies were identified through databases such as Google Scholar, Web of Science, PubMed, and Scopus. Using STATA version 14, we systematically extracted data employing a checklist. Heterogeneity was evaluated using I2 tests and the Cochrane Q test statistic. To assess publication bias, a funnel plot, Begg's test, and Egger's weighted regression were employed.</div></div><div><h3>Results</h3><div>In this systematic review and meta-analysis, 1770 research articles were identified, with thirteen studies meeting eligibility criteria for analysis. The pooled prevalence of evidence-based intrapartum care practices was 49.50 % (95 % CI: 39.02–59.98). Factors significantly associated with these practices included good knowledge (OR = 2.64, 95 % CI: 2.04–3.41), in-service training related to intrapartum practice (OR = 2.38, 95 % CI: 1.55–3.64), positive attitudes towards intrapartum care practice (OR = 2.68, 95 % CI: 1.78–4.03), a higher number of obstetric care providers per shift (OR = 2.54, 95 % CI: 1.27–5.10), and educational attainment at the level of Master's degree and above (OR = 4.92, 95 % CI: 2.45–9.91).</div></div><div><h3>Conclusion</h3><div>This study reveals that despite recognizing the importance of evidence-based intrapartum practices, only half of the observed obstetric care providers apply them. Factors influencing their application include knowledge, in-service training, attitudes, staffing, and education. Recommendations include continuous knowledge enhancement, reinforced in-service training, and psychological support. Optimizing staffing and creating pathways for advanced degrees are also proposed to improve evidence-based intrapartum care practices.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"28 ","pages":"Article 100431"},"PeriodicalIF":1.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perinatal outcomes after increased fetal movement as counted by a fetal movement acceleration measurement recorder","authors":"Eiji Ryo,&nbsp;Hideo Kamata,&nbsp;Keita Yatsuki,&nbsp;Takashi Kosaka,&nbsp;Kazunori Nagasaka","doi":"10.1016/j.eurox.2025.100428","DOIUrl":"10.1016/j.eurox.2025.100428","url":null,"abstract":"<div><h3>Introduction</h3><div>There is no consensus in perinatal medicine about what increased fetal movement means.</div></div><div><h3>Objective</h3><div>Our purpose was to study the relationship between perinatal outcomes and an increase in gross fetal movement as counted by an objective method.</div></div><div><h3>Methods</h3><div>This was a prospective cohort study. A total of 471 pregnant women recorded fetal movement with a fetal movement acceleration measurement recorder at night weekly after 28 weeks. The ratio of 10-second epochs with fetal movement to all epochs was calculated as a fetal movement parameter when movement could be recorded for more than 4 h on one night. If the parameter was above the 90th percentile on the previously made reference curve, it was defined as increased movement. Women who showed the increased fetal movement at least once were classified into a study group, and the other women were classified into a control group. Perinatal abnormalities between the two groups were compared with the Chi-square test or Fisher’s exact test.</div></div><div><h3>Results</h3><div>A total of 13,931 h were recorded from 390 women, including 74 and 316 women, respectively, in the study and control groups. There were fewer preterm births (1.4 %), non-cephalic presentations at delivery (0 %), and Cesarean deliveries (25.7 %) in the study group than in the control group (15.5 %, 6.0 %, and 39.9 %; p = 0.0003, 0.031, and 0.024, respectively). There were no significant differences in the other perinatal outcomes.</div></div><div><h3>Conclusion</h3><div>An increase in long-term gross fetal movement has a protective effect against preterm birth, non-cephalic presentation at birth, and Cesarean delivery.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"28 ","pages":"Article 100428"},"PeriodicalIF":1.7,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145098017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of curcumin capsule on the severity and duration of primary dysmenorrhea among students: A triple-blind randomized controlled trial in the West of Iran","authors":"Sara Abdoli ,&nbsp;Salman Khazaei ,&nbsp;Maryam Mehrpooya ,&nbsp;Farideh kazemi ,&nbsp;Ensiyeh jenabi ,&nbsp;Reyhane Yazdaniroshan","doi":"10.1016/j.eurox.2025.100427","DOIUrl":"10.1016/j.eurox.2025.100427","url":null,"abstract":"<div><h3>Background</h3><div>The present study was conducted to evaluate the efficacy of curcumin capsules on the severity and duration of primary dysmenorrhea.</div></div><div><h3>Methods</h3><div>A randomized controlled trial conducted among female students at Hamadan University of Medical Sciences who met predetermined inclusion criteria in 2024 at 34 participants per group. In the intervention group, participants received curcumin capsules containing 500 mg of curcumin. These capsules were ingested once daily over the course of two menstrual cycles. The control group was administered placebo capsules, which contained 500 mg of starch, with the method of administration mirroring that of the intervention group. Data collection tools were including demographic characteristics questionnaire, visual pain ruler, pain duration and multidimensional verbal scale.</div></div><div><h3>Results</h3><div>after the intervention, a significant difference emerged (P &lt; 0.001). In the intervention group, dysmenorrhea severity decreased significantly from a mean of 6.5–4.53 in the first menstrual cycle and further reduced to 3.44 in the second cycle. In contrast, the control group showed no significant change. The intervention group's improvement was consistent across both cycles, highlighting the effectiveness of the intervention in reducing dysmenorrhea severity (P &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>curcumin capsules can be used as an effective and low-risk complementary treatment for reducing the severity and duration of primary dysmenorrhea.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"28 ","pages":"Article 100427"},"PeriodicalIF":1.7,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of clinical usability and reproducibility of the American Society for Reproductive Medicine Müllerian Anomalies Classification","authors":"Julia Lastinger ,&nbsp;Natalia Palasz ,&nbsp;Peter Oppelt ,&nbsp;Galymzhan Toktarbekov ,&nbsp;Milan Terzic ,&nbsp;Raimund Stein ,&nbsp;Katharina Rall ,&nbsp;Helga Wagner ,&nbsp;Philipp Hermann ,&nbsp;Stephanie Kiblboeck","doi":"10.1016/j.eurox.2025.100425","DOIUrl":"10.1016/j.eurox.2025.100425","url":null,"abstract":"<div><h3>Objective</h3><div>To study the usability, reproducibility and practicality of the revised American Society for Reproductive Medicine Müllerian Anomalies Classification (ASRM MAC2021) compared to the formerly used American Fertility Society (AFS) classification. The main focus of this paper is to present clinicians’ assessment when using these classification systems and to explore possible benefits and disadvantages of the transformation of the AFS into the more recently published ASRM classification. To incorporate all commonly used classification systems, all cases were additionally classified using the ESHRE/ESGE and the VCUAM classification.</div></div><div><h3>Methods</h3><div>An observational study using a questionnaire and opinion survey was conducted with the goal of comparing clinicians’ subjective usability and reproducibility of the AFS classification with the newly presented ASRM MAC2021 classification. Cases of female genital malformations encompassed a wide range of various anomalies, including vaginal, cervical and adnexal conditions and associated malformations.</div></div><div><h3>Results</h3><div>The study investigators rated the ASRM MAC2021 classification better in relation to usability and reproducibility compared to the AFS classification. It significantly improved diagnostic precision for vaginal and cervical anomalies and expanded recognition of adnexal malformations. However, challenges remain in addressing associated malformations. Clinicians ranked the ASRM MAC2021 higher than the AFS classification. However, investigators rated the ESHRE/ESGE and VCUAM classifications better in the overall assessment of female genital malformations.</div></div><div><h3>Conclusion</h3><div>The ASRM MAC2021 classification offers substantial improvements in diagnosing and managing female genital malformations, addressing limitations of the AFS system. With better usability and subjective reproducibility, further refinements are needed to fully address complex associated anomalies — emphasizing the importance of evolving classification systems.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"27 ","pages":"Article 100425"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Characteristics of Mother–Infant Dyadic Synchrony Among Vulnerable Mothers Using the Infant CARE-Index","authors":"Camilla Ejlertsen ,&nbsp;Ingeborg Hedegaard Kristensen ,&nbsp;Anne Brødsgaard","doi":"10.1016/j.eurox.2025.100426","DOIUrl":"10.1016/j.eurox.2025.100426","url":null,"abstract":"<div><h3>Objective</h3><div>The postnatal period crucially influences the mother–infant relationship and subsequently the infant’s cognitive, physical, and psychosocial development. Maternal poor mental health may impact early interactions, potentially causing the infant’s developmental needs to go neglected.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, we used the Infant CARE-Index to examine mother–infant interaction patterns among mothers with a history of depression or anxiety. Ten mother–infant dyads recruited from a Danish obstetric department participated in video recordings of mother–infant interactions three months postpartum. The primary outcome was the assessment of mother–infant dyadic synchrony using observational measures of the Infant CARE-Index when infants were three months old.</div></div><div><h3>Results</h3><div>Mother–infant dyadic synchrony was found to lack sensitivity, with maternal behaviour predominantly exhibiting low sensitivity and, occasionally, control, leading to overall unresponsiveness. The infants in the dyads exhibited moderately cooperative behaviour but with tendencies towards compulsive and challenging behaviours.</div></div><div><h3>Conclusion</h3><div>This study offers novel observational insights into early relational dynamics in mother–infant dyads affected by maternal mental health history—an area underexplored in Danish postnatal care. By applying the Infant CARE-Index, the findings highlight specific behavioural patterns that may hinder bonding and development. These results underscore the need for relationship-based, targeted, and flexible interventions to support vulnerable dyads and promote healthier developmental trajectories.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"27 ","pages":"Article 100426"},"PeriodicalIF":1.7,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring woman’s perception of support and control during childbirth: Psychometric proprieties of the SCIB scale in an Italian sample","authors":"Sara Molgora ,&nbsp;Federica Bonazza ,&nbsp;Maurizio Barbieri Carones ,&nbsp;Enrico Maria Ferrazzi ,&nbsp;Elizabeth Ford","doi":"10.1016/j.eurox.2025.100424","DOIUrl":"10.1016/j.eurox.2025.100424","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to develop an Italian version of the Support and Control in Birth (SCIB) and to test its reliability and validity.</div></div><div><h3>Methods</h3><div>The sample included 414 post-partum women, who were recruited 24/48 h after giving birth. A study-specific online questionnaire was designed to collect sociodemographic information and administer the translated Italian version of the SCIB. The construct validity of the Italian SCIB was first analyzed using Confirmatory Factor Analysis (CFA). Based on metrics showing a poor fit, Exploratory Factor Analysis (EFA) was then executed. The reliability of the instrument was verified through Cronbach’s alpha for each subscale and the total scale and test-retest correlation coefficient.</div></div><div><h3>Results</h3><div>CFA was performed to test the original three-factor theoretical model; however, the CFA solution showed a poor fit. Specifically, χ2 = 2100, df= 492, p &lt; 0.001, RMSEA = 0.0888 (0.085 – 0.0928), and CFI = 0.45. The theoretical model did not adequately fit the observed data. Thus, EFA was conducted; it yielded a six-factor structure. The six factors were named: Support: healthcare professionals’ guidance; Support: healthcare professionals’ presence; External control: control over medical procedures; External control: control over the informational process; Internal control: control over emotional and physical reactions; Internal control: control over pain. These factors replicate the originals dimensions, each divided into two further subfactors.</div></div><div><h3>Conclusion</h3><div>Findings enhance knowledge about childbirth by cross-culturally adapting an instrument to assess perceptions of control and support, fundamental factors in birth experience. SCIB could help health professionals to monitor women's childbirth experiences and introduce tailored interventions.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"27 ","pages":"Article 100424"},"PeriodicalIF":1.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change management - digitalisation of labor room: A mixed-methods study to assess the level of acceptance of 'Arc Partograph' application to go paperless in labor rooms.","authors":"Gaurang Narayan, Alka Patankar, Daya Narayan, Tarun Kumar Suvvari, Anchit Chauhan","doi":"10.1016/j.eurox.2025.100423","DOIUrl":"10.1016/j.eurox.2025.100423","url":null,"abstract":"<p><strong>Introduction: </strong>Delivery-related complications significantly contribute to maternal, fetal, and neonatal mortality, particularly in low-resource settings like India. Effective labor monitoring, exemplified by the WHO-endorsed partograph, is crucial but often underutilized due to various challenges. The transition to digital partographs offers potential benefits but faces obstacles that need to be addressed, especially regarding healthcare workers' acceptance and readiness for such changes.</p><p><strong>Materials and methods: </strong>This explanatory sequential mixed-methods study was conducted at a public tertiary hospital in Nagpur, India, over two months in 2024. After demonstrating the 'arcPartograph' application, a web-based tool for digital labor monitoring, 60 obstetricians participated in a quantitative survey, followed by a focused group discussion (FGD) with a subset of participants. Data were analyzed using both statistical methods and manual content analysis.</p><p><strong>Results: </strong>Among the 75 obstetricians contacted, 60 (80 %) participated, with 91.7 % (n = 55) expressing readiness to transition from paper-based to digital partographs, and 93.3 % (n = 56) willing to use the 'arcPartograph' application. Participants showed strong readiness for digital adoption (mean score 16.2) and positive perceptions (mean score 16.1), though global change acceptance was relatively low (mean score 27.0). No significant associations were found between socio-demographic factors and willingness to adopt digital tools. The FGD revealed diverse perceptions, identifying both facilitators and barriers to digital change management.</p><p><strong>Conclusion: </strong>The study highlights a strong readiness among obstetricians to embrace digital partographs, underscoring the need for targeted strategies to address technical and logistical challenges for successful implementation in low-resource settings.</p>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"27 ","pages":"100423"},"PeriodicalIF":1.7,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12356401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of an integrated continuous team midwifery care model on the quality of antenatal care in Iran’s health system: A randomized controlled trial","authors":"Farzaneh Nasiri ,&nbsp;Azam bagheri ,&nbsp;Maryam Dastoorpour ,&nbsp;Shahla Khosravi ,&nbsp;Zahra Abbaspoor","doi":"10.1016/j.eurox.2025.100420","DOIUrl":"10.1016/j.eurox.2025.100420","url":null,"abstract":"<div><h3>Background and aims</h3><div>In maternity care, high quality prenatal care is essential for both women and babies. Continuity and coordination of midwifery care are very crucial in improving the quality of care. The present study investigated the effectiveness of an integrated continuous team midwifery care model (ICTMC) on the quality of antenatal care in Iran’s health system.</div></div><div><h3>Methods</h3><div>This randomized controlled trial included 200 low-risk nulliparous women selected from governmental health centers in Kashan, Iran during 2023–2024. The women were randomized into two groups, with block sizes of four and six, maintaining a 1:1 allocation ratio. A dedicated team of midwives offered continuous care throughout the gestation, labor and parturition periods plus postnatal care (6 weeks after birth) for the women in the intervention group. The control group, on the other hand, received standard care from various midwives during the same periods. A demographic questionnaire, and the Quality of Prenatal Care Questionnaire were used for data collection. Data were analyzed using descriptive and inferential statistics in STATA-17</div></div><div><h3>Results</h3><div>The ICTMC group exhibited a significantly higher mean of quality of prenatal care scores compared to the control group (158.83 ± 17.13 vs.133.51 ± 24.48, p &lt; 0.001), and this superiority was observed in all dimensions of this scale.</div></div><div><h3>Conclusion</h3><div>The present study offers evidence for the benefits of ICTMC, A collaborative approach among inform policymakers, healthcare providers, and researchers is recommended to facilitate the implementation of ICTMC within the Iranian healthcare system.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"27 ","pages":"Article 100420"},"PeriodicalIF":1.7,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144826633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life, sexual function and metabolic parameters of women during 10 years of using the etonogestrel implant","authors":"Salvatore Caruso ,&nbsp;Angelo Cagnacci ,&nbsp;Giuseppe Caruso ,&nbsp;Stefano Cianci ,&nbsp;Marco Palumbo","doi":"10.1016/j.eurox.2025.100421","DOIUrl":"10.1016/j.eurox.2025.100421","url":null,"abstract":"<div><h3>Objective</h3><div>To study the effects on the quality of life (QoL), sexual function and metabolic aspects in women using a subcutaneous implant containing Etonogestrel (ENG-implant) over 10 years of observation period.</div></div><div><h3>Study design</h3><div>This study was performed from January 2011 to September 2023. A database was set up to collect data from women. Counseling on the ENG-implant to be inserted at the termination of pregnancy, and on insert a new device every 3 years was adopted. The Short Form-36 (SF-36), the Female Sexual Function Index (FSFI) and the Female Sexual Distress Scale (FSDS) questionnaires were used to investigate the QoL, sexual function and sexual distress, respectively, of women at baseline and at 6, 12, 24, 36, 72 and 108-month follow-ups. Blood samples were collected from women to measure metabolic parameters.</div></div><div><h3>Results</h3><div>32 of 52 (61.5 %) enrolled women completed the study. In summary, after removing the first (at 36th month of use) and the second implant (at 72nd month of use), 44 (84.6 %) and 32 (61.5 %) women asked for the insertion of a new device, respectively. Somatic (p &lt; 0.001) and mental (p = 0.04) categories of SF-36 improved from the 12-month follow-up to the 108-month follow-up (p &lt; 0.001). FSFI scores also increased from 12-month follow-up to the 108-month follow-up (p &lt; 0.001). The improvement of the total scores depended on the gradual increase in each FSFI item (p &lt; 0.001).</div><div>FSDS score became statistically significant starting from the 12-month follow-up to the 108-month follow-up (p &lt; 0.001). Although lipid metabolism, fasting glucose, liver function and hemostatic parameters were slightly reduced, they remained within the range of the normal values.</div></div><div><h3>Conclusions</h3><div>The long observation period of 10 years allowed us to state that the ENG-implant could have neutral effects on metabolic parameters, promote a better quality of life, and improve sexuality in the users. The main limitation of our study was the small number of women enrolled, mainly due to the cost of the implant. These results should be confirmed on a larger sample.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"27 ","pages":"Article 100421"},"PeriodicalIF":1.7,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144810380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}