Pub Date : 2021-09-30DOI: 10.20473/CCJ.V2I2.2021.95-109
H. Hariadi, M. T. Giani, Silvia Handika Anggraeni
Abstract: Diabetes mellitus (DM) is one of the most prevalent and burdensome among chronic disease worldwide. Its complications accelerate mortality rate within population. Diabetic cardiomyopathy (DCM) is one of diabetes macrovascular complications, which symptoms are frequently unforeseen. Advances in pathogenesis understanding DCM underlying mechanisms remain not fully perceived. Current diagnostic approach of DCM can hardly determine diabetic patients with asymptomatic cardiomyopathy. Previous studies suggested biomarkers might detect early stage DCM. There are numerous selective biomarkers representing several pathophysiological pathways, such as myocardial fibrosis, inflammatory response, cardiomyocyte apoptosis, and metabolic dysregulation in the development of diabetic heart anomaly It was also reported those biomarkers are useful for the prognostic assessment of the disease. However, not all biomarkers are cardiac specific and can be an auspicious diagnostic tool candidate. Recent studies show that there are certain biomarkers, such as microRNA, H-FABP, IGFBP7, and some other novel cardiac biomarkers were more specifically associated with the pathological mechanism of DCM. In this review, we aimed to discuss the role of several potential cardiac biomarkers as early detection in DCM that may predict future incident of DCM, and contribute to improving mortality prediction in patients with subclinical DCM.Keywords: Biomarker; Diabetic Cardiomyopathy
{"title":"Potential Biomarkers as Early Detection of Diabetic Cardiomyopathy","authors":"H. Hariadi, M. T. Giani, Silvia Handika Anggraeni","doi":"10.20473/CCJ.V2I2.2021.95-109","DOIUrl":"https://doi.org/10.20473/CCJ.V2I2.2021.95-109","url":null,"abstract":"Abstract: Diabetes mellitus (DM) is one of the most prevalent and burdensome among chronic disease worldwide. Its complications accelerate mortality rate within population. Diabetic cardiomyopathy (DCM) is one of diabetes macrovascular complications, which symptoms are frequently unforeseen. Advances in pathogenesis understanding DCM underlying mechanisms remain not fully perceived. Current diagnostic approach of DCM can hardly determine diabetic patients with asymptomatic cardiomyopathy. Previous studies suggested biomarkers might detect early stage DCM. There are numerous selective biomarkers representing several pathophysiological pathways, such as myocardial fibrosis, inflammatory response, cardiomyocyte apoptosis, and metabolic dysregulation in the development of diabetic heart anomaly It was also reported those biomarkers are useful for the prognostic assessment of the disease. However, not all biomarkers are cardiac specific and can be an auspicious diagnostic tool candidate. Recent studies show that there are certain biomarkers, such as microRNA, H-FABP, IGFBP7, and some other novel cardiac biomarkers were more specifically associated with the pathological mechanism of DCM. In this review, we aimed to discuss the role of several potential cardiac biomarkers as early detection in DCM that may predict future incident of DCM, and contribute to improving mortality prediction in patients with subclinical DCM.Keywords: Biomarker; Diabetic Cardiomyopathy","PeriodicalId":371103,"journal":{"name":"Cardiovascular and Cardiometabolic Journal (CCJ)","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131392081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-30DOI: 10.20473/ccj.v2i2.2021.59-72
Ikhsanuddin Qothi, M. Fuadi, Agus Subagjo
Abstract: Background: Coronary heart disease (CHD) is a leading cause of death worldwide. One type of CHD that most often causes clinical manifestations and death is Acute Coronary Syndrome (ACS). In 2013 the prevalence of SKA in Indonesia reached 1.5% and it is estimated that it will continue to increase every year. Objective: This study aims to determine the profile of major risk factors for ACS sufferers in the Pusat Pelayanan Jantung Terpadu (PPJT) Dr. Soetomo Public Hospital Surabaya in the period January-December 2019. Methods: This study used a retrospective descriptive method to analyze the patient's electronic medical record (e-MR). Results: Out of 623 patients diagnosed with ACS, 429 were excluded from the research. 194 patients who met the inclusion criteria were studied with the following details: 19 APTS patients, 43 N-STEMI patients, and 132 STEMI patients. It was found that 73% of ACS patients were male, with the 55-64 years’ age group dominating by 46%. Based on blood pressure and serum cholesterol examination data, it was found that 51% of patients had hypertension and 77% of patients had dyslipidemia (40% hypercholesterolemia, 42% hypertriglyceridemia, 40% low HDL-C levels, and 34% high LDL-C levels). 60% patients had type-2 diabetes mellitus and 52% of patients had a history of smoking. Conclusion: 73% of ACS patients in this study were men. Most common age groups were 55-64 years old (46%), had hypertension by 51%, had dyslipidemia by 77% (40% hypercholesterolemia, 42% hypertriglyceridemia, 40% low HDL-C levels, 34% high LDL-C), had type-2 diabetes mellitus by 60%, and had a smoking history by 52%.
{"title":"Profile of Major Risk Factors in Acute Coronary Syndrome (ACS) at Pusat Pelayanan Jantung Terpadu (PPJT) Dr. Soetomo Public Hospital Surabaya Between the Period of January-December 2019","authors":"Ikhsanuddin Qothi, M. Fuadi, Agus Subagjo","doi":"10.20473/ccj.v2i2.2021.59-72","DOIUrl":"https://doi.org/10.20473/ccj.v2i2.2021.59-72","url":null,"abstract":"Abstract: Background: Coronary heart disease (CHD) is a leading cause of death worldwide. One type of CHD that most often causes clinical manifestations and death is Acute Coronary Syndrome (ACS). In 2013 the prevalence of SKA in Indonesia reached 1.5% and it is estimated that it will continue to increase every year. Objective: This study aims to determine the profile of major risk factors for ACS sufferers in the Pusat Pelayanan Jantung Terpadu (PPJT) Dr. Soetomo Public Hospital Surabaya in the period January-December 2019. Methods: This study used a retrospective descriptive method to analyze the patient's electronic medical record (e-MR). Results: Out of 623 patients diagnosed with ACS, 429 were excluded from the research. 194 patients who met the inclusion criteria were studied with the following details: 19 APTS patients, 43 N-STEMI patients, and 132 STEMI patients. It was found that 73% of ACS patients were male, with the 55-64 years’ age group dominating by 46%. Based on blood pressure and serum cholesterol examination data, it was found that 51% of patients had hypertension and 77% of patients had dyslipidemia (40% hypercholesterolemia, 42% hypertriglyceridemia, 40% low HDL-C levels, and 34% high LDL-C levels). 60% patients had type-2 diabetes mellitus and 52% of patients had a history of smoking. Conclusion: 73% of ACS patients in this study were men. Most common age groups were 55-64 years old (46%), had hypertension by 51%, had dyslipidemia by 77% (40% hypercholesterolemia, 42% hypertriglyceridemia, 40% low HDL-C levels, 34% high LDL-C), had type-2 diabetes mellitus by 60%, and had a smoking history by 52%.","PeriodicalId":371103,"journal":{"name":"Cardiovascular and Cardiometabolic Journal (CCJ)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129737660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-30DOI: 10.20473/ccj.v2i2.2021.73-76
Raditya Rizki Muhammad, Nadya Anisah, A. Kurniawan, Hairudi Hairudi
COVID-19 pandemic has become a global issues, especially involving cardiovascular diseases. The management of COVID-19 patients with ST-Segment elevation in early pandemic era faces new challenges. Challenges can occur in term of patient’s delay and healthcare safety. This case series discussed clinical manifestations, examination findings, alternative strategies including thrombolytic and conservative therapy, and patients’ outcomes.
{"title":"Clinical Manifestation and Outcomes of Thrombolytic and Consevative Therapy in Covid-19 Patients with ST-Segment Elevation Pattern: A Case Series","authors":"Raditya Rizki Muhammad, Nadya Anisah, A. Kurniawan, Hairudi Hairudi","doi":"10.20473/ccj.v2i2.2021.73-76","DOIUrl":"https://doi.org/10.20473/ccj.v2i2.2021.73-76","url":null,"abstract":"COVID-19 pandemic has become a global issues, especially involving cardiovascular diseases. The management of COVID-19 patients with ST-Segment elevation in early pandemic era faces new challenges. Challenges can occur in term of patient’s delay and healthcare safety. This case series discussed clinical manifestations, examination findings, alternative strategies including thrombolytic and conservative therapy, and patients’ outcomes.","PeriodicalId":371103,"journal":{"name":"Cardiovascular and Cardiometabolic Journal (CCJ)","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133568558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-27DOI: 10.20473/CCJ.V2I1.2021.10-15
Ahmad Alhamid, H. Yulidia, Intan Iriani Supriatna
Background: Accurate risk stratification for untoward outcomes after acute coronary syndrome patients may help clinicians guide the type and intensity of therapy. Unfortunately, most of the Papuanese people face difficulties in accessing sophisticated medical treatment. Aims: The aim of this study was to determine the simplest but most accurate risk stratification for ACS patients treated in rural hospital. Methods: This was a cross-sectional study conducted in Sele Be Solu Regional Hospital at Sorong Regency in West Papua Province. Fifteen unselected patients from September 2019 to March 2020 period with ACS were prospectively studied. All the data were collected from medical records. Results: Subject characteristics mostly were male (80%) and mean age was 54 years, (13,3%) subjects were age less than 45 years. The most diagnosed ACS type was STEMI (73,3%). Conclusion:In Papuanese patients with ACS in rural hospital, those at highest risk can be identified using Killip classification and The Six-minute Walk Test Borg Scale as short term predictor for ACS patients’ outcome.
背景:对急性冠状动脉综合征患者的不良结局进行准确的危险分层可以帮助临床医生指导治疗的类型和强度。不幸的是，大多数巴布亚人在获得尖端医疗方面面临困难。目的:本研究的目的是确定在农村医院治疗的ACS患者最简单但最准确的风险分层。方法:这是在西巴布亚省索隆县的Sele Be Solu地区医院进行的一项横断面研究。前瞻性研究了2019年9月至2020年3月期间15例未选择的ACS患者。所有的数据都是从医疗记录中收集的。结果:受试者以男性为主(80%)，平均年龄54岁，年龄小于45岁的占13.3%。确诊最多的ACS类型是STEMI(73.3%)。结论:在农村医院的巴布亚ACS患者中，可以使用Killip分级和6分钟步行测试博格量表作为ACS患者预后的短期预测指标来识别高危患者。
{"title":"Simple Risk Stratification based on Killip Classification and the Six-minute Walk Test Borg Scale for Outcomes of Acute Coronary Syndrome for Papuanese People in Rural Hospital","authors":"Ahmad Alhamid, H. Yulidia, Intan Iriani Supriatna","doi":"10.20473/CCJ.V2I1.2021.10-15","DOIUrl":"https://doi.org/10.20473/CCJ.V2I1.2021.10-15","url":null,"abstract":"Background: Accurate risk stratification for untoward outcomes after acute coronary syndrome patients may help clinicians guide the type and intensity of therapy. Unfortunately, most of the Papuanese people face difficulties in accessing sophisticated medical treatment. Aims: The aim of this study was to determine the simplest but most accurate risk stratification for ACS patients treated in rural hospital. Methods: This was a cross-sectional study conducted in Sele Be Solu Regional Hospital at Sorong Regency in West Papua Province. Fifteen unselected patients from September 2019 to March 2020 period with ACS were prospectively studied. All the data were collected from medical records. Results: Subject characteristics mostly were male (80%) and mean age was 54 years, (13,3%) subjects were age less than 45 years. The most diagnosed ACS type was STEMI (73,3%). Conclusion:In Papuanese patients with ACS in rural hospital, those at highest risk can be identified using Killip classification and The Six-minute Walk Test Borg Scale as short term predictor for ACS patients’ outcome. ","PeriodicalId":371103,"journal":{"name":"Cardiovascular and Cardiometabolic Journal (CCJ)","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116025992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-27DOI: 10.20473/CCJ.V2I1.2021.41-49
R. M. Budiarto, MD, Muhammad Hasan
A 44-year-old man was admitted to hospital to be performed re-thrombectomy after previously performed thrombectomy at the referring hospital but did not show clinical improvement. CT angiography results before re-thrombectomy showed a central thrombus measuring 1.1 cm in diameter, and an impression of 2.6 cm long at the branching of the right external Iliaca artery which caused total obstruction of the right illiaca external artery to the distal. Aortofemoral bypass graft surgery is a procedure utilized commonly for the treatment of aortoiliac occlusive disease. The treatment given to manage symptoms if medical management or minimally invasive therapy, such as balloon angioplasty and stenting, was unsuccessful or unsuitable for the patient. Aortofemoral bypass graft surgical procedure was performed on the patient. However, post procedure angiography showed no visible flow through the newly placed graft. A repair graft procedure was planned for the patient, but the patient refused to undergo further surgical procedures.
{"title":"Aorto Femoral Bypass Graft in Chronic Limb Ischemia Patient","authors":"R. M. Budiarto, MD, Muhammad Hasan","doi":"10.20473/CCJ.V2I1.2021.41-49","DOIUrl":"https://doi.org/10.20473/CCJ.V2I1.2021.41-49","url":null,"abstract":"A 44-year-old man was admitted to hospital to be performed re-thrombectomy after previously performed thrombectomy at the referring hospital but did not show clinical improvement. CT angiography results before re-thrombectomy showed a central thrombus measuring 1.1 cm in diameter, and an impression of 2.6 cm long at the branching of the right external Iliaca artery which caused total obstruction of the right illiaca external artery to the distal. Aortofemoral bypass graft surgery is a procedure utilized commonly for the treatment of aortoiliac occlusive disease. The treatment given to manage symptoms if medical management or minimally invasive therapy, such as balloon angioplasty and stenting, was unsuccessful or unsuitable for the patient. Aortofemoral bypass graft surgical procedure was performed on the patient. However, post procedure angiography showed no visible flow through the newly placed graft. A repair graft procedure was planned for the patient, but the patient refused to undergo further surgical procedures.","PeriodicalId":371103,"journal":{"name":"Cardiovascular and Cardiometabolic Journal (CCJ)","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128735601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-27DOI: 10.20473/CCJ.V2I1.2021.82-90
Rosavelina Sintaasih Budihardjo, Agus Subagjo, S. Prajitno
Background: Cardiovascular disease is the number one cause of death in the world by killing 17,9 million people every year. The most frequent cardiovascular disease occurs as STEMI which related to the depiction of persistent depiction of EKG elevation with ST segment. This research is aiming for figure out the profile of reperfusion therapy at Dr. Soetomo General Academic Hospital, Surabaya. Methods: In this research, the data is collected using observation method, without any treatment applied with descriptive statistical analysis using table. The data collection techniques used is simple random sampling. Results: The STEMI patients at Dr. Soetomo General Academic Hospital Surabaya are dominated by referral patients (79,2%) from approximately 40 hospitals in East Java. Most of the patients were male, the ages between 51 – 60 years old with the most frequent risk factors was the combination of type 2 diabetes mellitus, hypertension, and smoking. The reperfusion therapy given was PCI with a door to balloon <120 minutes was 59.6%. Fibrinolytic that was done in <12 hours after onset was 82.9%. Patients with STEMI managed at Dr. Soetomo General Academic Hospital Surabaya, had mortality rates around 12.2%. Conclusion: Most of the STEMI patients in Dr. Sutomo General Academic Hospital Surabaya was a referral patient and had sufficiently good PCI and fibrinolytic reperfusion therapy, resulting in a low mortality rate.
背景:心血管疾病是世界头号死因，每年造成1790万人死亡。最常见的心血管疾病是STEMI，这与ST段心电图持续升高的描述有关。本研究旨在了解泗水Soetomo博士综合学术医院的再灌注治疗概况。方法:本研究采用观察法收集资料，未采用表格描述性统计分析处理。使用的数据收集技术是简单的随机抽样。结果:Dr. Soetomo General Academic Hospital Surabaya的STEMI患者主要是来自东爪哇约40家医院的转诊患者(79.2%)。患者以男性居多，年龄在51 ~ 60岁之间，2型糖尿病、高血压和吸烟是最常见的危险因素。再灌注治疗为PCI，门到球囊<120分钟，占59.6%。发病后<12小时内溶栓率为82.9%。泗水Soetomo博士综合学术医院治疗的STEMI患者死亡率约为12.2%。结论:泗水Sutomo总医院STEMI患者多为转诊患者，PCI和纤溶再灌注治疗效果良好，死亡率低。
{"title":"Reperfusion Therapy for ST-Elevation Myocardial Infarction at Dr. Soetomo General Academic Hospital Surabaya","authors":"Rosavelina Sintaasih Budihardjo, Agus Subagjo, S. Prajitno","doi":"10.20473/CCJ.V2I1.2021.82-90","DOIUrl":"https://doi.org/10.20473/CCJ.V2I1.2021.82-90","url":null,"abstract":"Background: Cardiovascular disease is the number one cause of death in the world by killing 17,9 million people every year. The most frequent cardiovascular disease occurs as STEMI which related to the depiction of persistent depiction of EKG elevation with ST segment. This research is aiming for figure out the profile of reperfusion therapy at Dr. Soetomo General Academic Hospital, Surabaya. Methods: In this research, the data is collected using observation method, without any treatment applied with descriptive statistical analysis using table. The data collection techniques used is simple random sampling. Results: The STEMI patients at Dr. Soetomo General Academic Hospital Surabaya are dominated by referral patients (79,2%) from approximately 40 hospitals in East Java. Most of the patients were male, the ages between 51 – 60 years old with the most frequent risk factors was the combination of type 2 diabetes mellitus, hypertension, and smoking. The reperfusion therapy given was PCI with a door to balloon <120 minutes was 59.6%. Fibrinolytic that was done in <12 hours after onset was 82.9%. Patients with STEMI managed at Dr. Soetomo General Academic Hospital Surabaya, had mortality rates around 12.2%. Conclusion: Most of the STEMI patients in Dr. Sutomo General Academic Hospital Surabaya was a referral patient and had sufficiently good PCI and fibrinolytic reperfusion therapy, resulting in a low mortality rate.","PeriodicalId":371103,"journal":{"name":"Cardiovascular and Cardiometabolic Journal (CCJ)","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131180916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-27DOI: 10.20473/CCJ.V2I1.2021.23-29
Ratna Mariana Tamba, A. Sitepu
Some cases of myocarditis have been reported associated to Covid-19. The presence of proinflammatory response from immune cells suggested occurs by binding to membrane protein ACE-2 leading to myocardial damage. Our hospital got a refferal from a non-PCI-capable hospital with a 51-years-old woman chest pain and progressive heavy breath with history of fever two days ago. She was diagnosed with anterior STEMI and cardiogenic shock on vassopressors. Her electrocardiogram showed shark fin appearance suggesting life-threatening STEMI. Her rapid test for covid-19 are non-reactive for both IgM and IgG. Her NCCT-thorax showed ground glass opacity in both lungs. Her laboratories finding showed elevated inflammatory markers and elevated cardiac biomarker. We took her naso-oro-pharingeal swab in the same day and process her with emergency PCI. Surprisingly, her angiography showed normal coronary artery without any significant stenosis. From There was no SARS-CoV-2 detected. In myocarditis, patient can mimick the same symptoms as STEMI such as chest pain and heavy breath with elevated cardiac biomarker, but the electrocardiogram usually shows widespread concave ST-elevation with PR-segment depression. Shark fin appearance is usually seen in life-threatening STEMI. In our patient, the NCCT-thorax showed GGO suggested Covid-19 involvement. But, the first swab was negative for SARS-CoV-2. Unfortunately, the patient was discharged without doctor’s consent, so we can not process the second swab and echocardiography to evaluate the function of myocardium. We still can not confirmed this case if it is true myocarditis-associated covid-19 and how was the involvement of the myocardium creating a shark fin mimicking life-threatening STEMI.
{"title":"A Suspected COVID-19-associated Myocarditis Case Mimicking Life-threatening STEMI: a Shark Fin Appearance","authors":"Ratna Mariana Tamba, A. Sitepu","doi":"10.20473/CCJ.V2I1.2021.23-29","DOIUrl":"https://doi.org/10.20473/CCJ.V2I1.2021.23-29","url":null,"abstract":"Some cases of myocarditis have been reported associated to Covid-19. The presence of proinflammatory response from immune cells suggested occurs by binding to membrane protein ACE-2 leading to myocardial damage. Our hospital got a refferal from a non-PCI-capable hospital with a 51-years-old woman chest pain and progressive heavy breath with history of fever two days ago. She was diagnosed with anterior STEMI and cardiogenic shock on vassopressors. Her electrocardiogram showed shark fin appearance suggesting life-threatening STEMI. Her rapid test for covid-19 are non-reactive for both IgM and IgG. Her NCCT-thorax showed ground glass opacity in both lungs. Her laboratories finding showed elevated inflammatory markers and elevated cardiac biomarker. We took her naso-oro-pharingeal swab in the same day and process her with emergency PCI. Surprisingly, her angiography showed normal coronary artery without any significant stenosis. From There was no SARS-CoV-2 detected. In myocarditis, patient can mimick the same symptoms as STEMI such as chest pain and heavy breath with elevated cardiac biomarker, but the electrocardiogram usually shows widespread concave ST-elevation with PR-segment depression. Shark fin appearance is usually seen in life-threatening STEMI. In our patient, the NCCT-thorax showed GGO suggested Covid-19 involvement. But, the first swab was negative for SARS-CoV-2. Unfortunately, the patient was discharged without doctor’s consent, so we can not process the second swab and echocardiography to evaluate the function of myocardium. We still can not confirmed this case if it is true myocarditis-associated covid-19 and how was the involvement of the myocardium creating a shark fin mimicking life-threatening STEMI.","PeriodicalId":371103,"journal":{"name":"Cardiovascular and Cardiometabolic Journal (CCJ)","volume":"125 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133636668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-27DOI: 10.20473/CCJ.V2I1.2021.30-35
Dian Paramita Kartikasari, R. Julario
Despite the increasing use of permanent cardiac pacemakers in a younger patient population, there are little data related to pregnancy. Normal physiologic alterations of pregnancy need to be taken into account in the management of the pregnant woman with a pacemaker in place. Similarly, gestational events including the potential for surgical intervention require a basic knowledge of pacemaker technology and monitoring. We present a case of a patient with junctional escape rhythm and was implanted pacemaker during pregnancy. A 24 years old women referred from obstetric outpatient clinic with asymptomatic bradycardia and cryptogenic stroke 2 years earlier. ECG shows sinus arrest with junctional escape rhythm. After multi-disciplinary discussion, team decided to implant double chamber pacemaker implantation. The pacemaker setting is adjusted to prepare caesarean section at 39 weeks gestation with delivery of an aterm infant. The postoperative course was uneventful. Pre-pregnancy pacemaker settings were re-established after the postpartum period. The current literature on managing pregnant patients with pacemakers is quite limited. Such patients require a multidisciplinary approach to care. Electromagnetic Interference (EMI) should be noticed.
{"title":"Cardiac Pacemaker in Pregnancy: How to Manage?","authors":"Dian Paramita Kartikasari, R. Julario","doi":"10.20473/CCJ.V2I1.2021.30-35","DOIUrl":"https://doi.org/10.20473/CCJ.V2I1.2021.30-35","url":null,"abstract":"Despite the increasing use of permanent cardiac pacemakers in a younger patient population, there are little data related to pregnancy. Normal physiologic alterations of pregnancy need to be taken into account in the management of the pregnant woman with a pacemaker in place. Similarly, gestational events including the potential for surgical intervention require a basic knowledge of pacemaker technology and monitoring. We present a case of a patient with junctional escape rhythm and was implanted pacemaker during pregnancy. A 24 years old women referred from obstetric outpatient clinic with asymptomatic bradycardia and cryptogenic stroke 2 years earlier. ECG shows sinus arrest with junctional escape rhythm. After multi-disciplinary discussion, team decided to implant double chamber pacemaker implantation. The pacemaker setting is adjusted to prepare caesarean section at 39 weeks gestation with delivery of an aterm infant. The postoperative course was uneventful. Pre-pregnancy pacemaker settings were re-established after the postpartum period. The current literature on managing pregnant patients with pacemakers is quite limited. Such patients require a multidisciplinary approach to care. Electromagnetic Interference (EMI) should be noticed. ","PeriodicalId":371103,"journal":{"name":"Cardiovascular and Cardiometabolic Journal (CCJ)","volume":"126 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132070900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-27DOI: 10.20473/CCJ.V2I1.2021.97-103
F. Azima
Abstract: Atherosclerosis is a problem of cardiovascular disease. Consuming food containing excessive fat is a risk factor for atherosclerosis. Soy milk has been studied for its isoflavones which has antihyperlipidemic effect on the development of atherosclerosis. The aim of this study was to find out the effect of soy milk (Glycine max (L.) Merr.) administration on aortic’s histopathology profile (the length of wall thickness and number of foam cells) in male white rats (Rattus norvegicus) which were given the atherogenic diet that consists of goat’s fat and quail egg yolk. Material and Methods: A total of 30 rats were used in the true laboratory experiment which were distributed into 5 groups (n=6) using post-test only design, there were a normal diet group, an atherogenic diet group, an atherogenic and simvastatin 10 mg group, and another 2 groups that were given an atherogenic diet with soy milk doses variation of 12.5 g and 25 g respectively. Aortic’s histopathology was prepared with the paraffin method and stained with Hematoxylin-Eosin. Results: ANOVA test showed that soy milk variation dose were significantly (p<0.05) reduce the aortic wall thickness and foam cell. Conclusion: Providing soy milk with a certain dose is able to decrease the aortic’s wall thickness and foam cells in rats fed an atherogenic diet.
{"title":"Anti-Atherosclerosis Effect of Soy Milk in Rats Fed an Atherogenic Diet","authors":"F. Azima","doi":"10.20473/CCJ.V2I1.2021.97-103","DOIUrl":"https://doi.org/10.20473/CCJ.V2I1.2021.97-103","url":null,"abstract":"Abstract: Atherosclerosis is a problem of cardiovascular disease. Consuming food containing excessive fat is a risk factor for atherosclerosis. Soy milk has been studied for its isoflavones which has antihyperlipidemic effect on the development of atherosclerosis. The aim of this study was to find out the effect of soy milk (Glycine max (L.) Merr.) administration on aortic’s histopathology profile (the length of wall thickness and number of foam cells) in male white rats (Rattus norvegicus) which were given the atherogenic diet that consists of goat’s fat and quail egg yolk. Material and Methods: A total of 30 rats were used in the true laboratory experiment which were distributed into 5 groups (n=6) using post-test only design, there were a normal diet group, an atherogenic diet group, an atherogenic and simvastatin 10 mg group, and another 2 groups that were given an atherogenic diet with soy milk doses variation of 12.5 g and 25 g respectively. Aortic’s histopathology was prepared with the paraffin method and stained with Hematoxylin-Eosin. Results: ANOVA test showed that soy milk variation dose were significantly (p<0.05) reduce the aortic wall thickness and foam cell. Conclusion: Providing soy milk with a certain dose is able to decrease the aortic’s wall thickness and foam cells in rats fed an atherogenic diet.","PeriodicalId":371103,"journal":{"name":"Cardiovascular and Cardiometabolic Journal (CCJ)","volume":"94 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125253715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.20473/ccj.v2i1.2021.36-40
Imam Mahbub Zam Zami
A 51-year-old male suffered from a STEMI inferior and a total AV block. Echocardiography shows hypokinetic wall motion at the inferior and inferoseptal that result in decreased EF. Coronary angiography revealed a single ostium of coronary artery without any stenosis. Cardiac CT revealed a single coronary artery arises from a single ostium from RCC and divided into RCA and LCA. There was an inter-arterial course of proximal RCA and proximal LCA between aorta and pulmonal artery. There was an acute angle take off of RCA from aorta. Inter-arterial course and acute angle take off of coronary artery from aorta result in kinking and narrowing of coronary artery that contributes to myocardial infarction. There is a mismatch between myocardial demand which is increased during exertion and myocardial oxygen delivery that decreased during exertion. A surgical anterior pulmonal transposition is the suggested choice of therapy.
{"title":"Inferior Myocardial Infarction and Total AV Block in a Patient with Single Ostium in the Right Sinus of Valsava (A Rare Congenital Coronary Anomaly)","authors":"Imam Mahbub Zam Zami","doi":"10.20473/ccj.v2i1.2021.36-40","DOIUrl":"https://doi.org/10.20473/ccj.v2i1.2021.36-40","url":null,"abstract":"A 51-year-old male suffered from a STEMI inferior and a total AV block. Echocardiography shows hypokinetic wall motion at the inferior and inferoseptal that result in decreased EF. Coronary angiography revealed a single ostium of coronary artery without any stenosis. Cardiac CT revealed a single coronary artery arises from a single ostium from RCC and divided into RCA and LCA. There was an inter-arterial course of proximal RCA and proximal LCA between aorta and pulmonal artery. There was an acute angle take off of RCA from aorta. Inter-arterial course and acute angle take off of coronary artery from aorta result in kinking and narrowing of coronary artery that contributes to myocardial infarction. There is a mismatch between myocardial demand which is increased during exertion and myocardial oxygen delivery that decreased during exertion. A surgical anterior pulmonal transposition is the suggested choice of therapy.","PeriodicalId":371103,"journal":{"name":"Cardiovascular and Cardiometabolic Journal (CCJ)","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126388781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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