T. V. Gorbunova, Al-Ariki Galal Abdulrahman Ali, I. V. Glekov, N. A. Susuleva, R. V. Shishkov, N. V. Ivanova, V. Polyakov
{"title":"Analysis of Treatment of the Outcomes in Pediatric Patients With Nasopharyngeal Cancer: A Retrospective Cohort Study","authors":"T. V. Gorbunova, Al-Ariki Galal Abdulrahman Ali, I. V. Glekov, N. A. Susuleva, R. V. Shishkov, N. V. Ivanova, V. Polyakov","doi":"10.15690/onco.v5i4.1969","DOIUrl":"https://doi.org/10.15690/onco.v5i4.1969","url":null,"abstract":"","PeriodicalId":37249,"journal":{"name":"Onkopediatria","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67157434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Lisitsa, E. Zhukovskaya, A. Ikonnikova, T. Nasedkina
Background. Venous thrombosis is extremely rare in children of early age; however, it occurs as a frequent and serious complication in children with hemoblastosis. The phenomenon is basically caused by the imbalance of blood coagulation system associated with the main disease, prolonged use of the central venous catheter, and polychemotherapy; hereditary predisposition contributes to the development of the complication as well. Clinical Case Description. A 12-year-old patient B. was diagnosed with Burkitt lymphoma. During chemotherapeutic treatment, the thrombosis of right internal jugular vein and right subclavian vein was registered. The thrombosis recurrence was observed at the end of specific therapy. The family history was burdened by cardiovascular and oncological diseases, consequently we performed the molecular-genetic analysis to reveal the presence of allelic variants associated with thrombophilia in the genes F2, F5, F9, F13A1, HABP2, HCF2, HRG, MTHFR, PLAT, PROC, PROS1, SERPINC1, THBD. The F5 gene Leiden mutation (c.1601G>A) in heterozygous state and intronic variant in the PROC gene encoding protein C (c.-21-37G>A) were revealed. The pharmacogenetic testing was conducted to personalize an ticoagulant and antiplatelet therapy.Conclusion. The detection of genetic risk factors for inherited thrombophilia is vital for early diagnostics of thrombotic complications in patients on chemotherapy. Key
{"title":"Venous Thrombosis in a Child with Burkitt Lymphoma Receiving Chemotherapy: A Clinical Case","authors":"T. Lisitsa, E. Zhukovskaya, A. Ikonnikova, T. Nasedkina","doi":"10.15690/onco.v5i3.1937","DOIUrl":"https://doi.org/10.15690/onco.v5i3.1937","url":null,"abstract":"Background. Venous thrombosis is extremely rare in children of early age; however, it occurs as a frequent and serious complication in children with hemoblastosis. The phenomenon is basically caused by the imbalance of blood coagulation system associated with the main disease, prolonged use of the central venous catheter, and polychemotherapy; hereditary predisposition contributes to the development of the complication as well. Clinical Case Description. A 12-year-old patient B. was diagnosed with Burkitt lymphoma. During chemotherapeutic treatment, the thrombosis of right internal jugular vein and right subclavian vein was registered. The thrombosis recurrence was observed at the end of specific therapy. The family history was burdened by cardiovascular and oncological diseases, consequently we performed the molecular-genetic analysis to reveal the presence of allelic variants associated with thrombophilia in the genes F2, F5, F9, F13A1, HABP2, HCF2, HRG, MTHFR, PLAT, PROC, PROS1, SERPINC1, THBD. The F5 gene Leiden mutation (c.1601G>A) in heterozygous state and intronic variant in the PROC gene encoding protein C (c.-21-37G>A) were revealed. The pharmacogenetic testing was conducted to personalize an ticoagulant and antiplatelet therapy.Conclusion. The detection of genetic risk factors for inherited thrombophilia is vital for early diagnostics of thrombotic complications in patients on chemotherapy. Key ","PeriodicalId":37249,"journal":{"name":"Onkopediatria","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67157263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Е. В. Горохова, Д. Ю. Качанов, Т. В. Шаманская, Е. П. Мацеха, А. М. Чилилова, М. В. Телешова, С. Р. Талыпов, В. Ю. Рощин, Дмитрий Михайлович Коновалов, А А Шабат, Галина Викторовна Терещенко, С. Р. Варфоломеева
Background. Pleuropulmonary blastoma (PPB) is a rare primary embryonal tumor of the lung in children. Three main histological variants of PPB with a possible transformation of type I into type II and III are now described. The prognosis in pleuropulmonary blastoma patients with distant metastases is considered to be unfavorable. Case Report. The article presents the case of type I PPB development in a 14-month-old child followed by the transformation of type I PPB into type II in the setting of relapse with multiple bone metastases. The aim of the article was to provide reliable data on successful treatment and achievement of long-term event-free survival in a PPB patient with multiple bone metastases who underwent intensive chemotherapy and high-dose therapy with autologous hematopoietic stem cell transplantation. Conclusion . The case study demonstrates the possibility for achievement of long-term event-free survival in PPB patients with multiple bone metastases and relapses.
{"title":"Успешное лечение пациента с плевропульмональной бластомой и множественными костными метастазами: клинический случай","authors":"Е. В. Горохова, Д. Ю. Качанов, Т. В. Шаманская, Е. П. Мацеха, А. М. Чилилова, М. В. Телешова, С. Р. Талыпов, В. Ю. Рощин, Дмитрий Михайлович Коновалов, А А Шабат, Галина Викторовна Терещенко, С. Р. Варфоломеева","doi":"10.15690/ONCO.V5I3.1936","DOIUrl":"https://doi.org/10.15690/ONCO.V5I3.1936","url":null,"abstract":"Background. Pleuropulmonary blastoma (PPB) is a rare primary embryonal tumor of the lung in children. Three main histological variants of PPB with a possible transformation of type I into type II and III are now described. The prognosis in pleuropulmonary blastoma patients with distant metastases is considered to be unfavorable. Case Report. The article presents the case of type I PPB development in a 14-month-old child followed by the transformation of type I PPB into type II in the setting of relapse with multiple bone metastases. The aim of the article was to provide reliable data on successful treatment and achievement of long-term event-free survival in a PPB patient with multiple bone metastases who underwent intensive chemotherapy and high-dose therapy with autologous hematopoietic stem cell transplantation. Conclusion . The case study demonstrates the possibility for achievement of long-term event-free survival in PPB patients with multiple bone metastases and relapses.","PeriodicalId":37249,"journal":{"name":"Onkopediatria","volume":"5 1","pages":"188-195"},"PeriodicalIF":0.0,"publicationDate":"2018-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67156933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background.Analysis of statistical data in the federal districts of the Russian Federation provides opportunities to assess the quality of medical care delivery in children with cancer and plan further development with consideration for the point elimination of existing defects. Objective. Our aim was to analyze the main indicators characterizing medical care for children with cancer in the North-West Federal District.Methods.The study analyzed operative reports for 2017 provided by the executive public health authorities of 11 subjects of the Russian Federation affiliated to the North-West Federal District.Results.The pediatric population was 2 537 133 children (0–17 years), the pediatric oncological bed capacity — 174 (0.7 per 10 000 aged 0–17 years), the annual berth average occupancy — 290.7 days. 6 (54.5%) subjects did not provide pediatric population with departments of pediatric oncology, 4 (36.4%) subjects did not have bed capacity. The number of practitioners providing medical care to children with cancer was 38, 27 among them (71%; 0.1 per 10 thousand 0–17 years) had a certificate of pediatric oncologist. 2 (18.2%) subjects did not have pediatric oncologists in the medical stuff. The incidence of malignant tumors in children aged 0–17 was 15.6 (per 100,000), the prevalence was 92.6 (per 100,000), the mortality rate was 2.6 (per 100,000), one-year mortality rate — 4.5% (18/397). The number of patients identified actively was 11 (2.8%). 160 (40.3%) primary patients were sent to Federal medical facilities, 6 (1.5%) — left the territory of the Russian Federation for the further treatment.Conclusion.The incidence and mortality rates are rather low which indicates the defects in patient detection and lack of reliable follow-up data. The percentage of patients referred for treatment to Federal medical facilities is not very high; however, to interpret this indicator according to patient routing, we have to analyze the medical history of all the patients. We can assert that health care delivery service for children with oncological diseases is at an acceptable standard level but needs to be improved.
{"title":"Medical Care for Children with Cancer in the North-West Federal District of the Russian Federation: An Ecological Study","authors":"M. Rykov, I. Turabov","doi":"10.15690/ONCO.V5I3.1933","DOIUrl":"https://doi.org/10.15690/ONCO.V5I3.1933","url":null,"abstract":"Background.Analysis of statistical data in the federal districts of the Russian Federation provides opportunities to assess the quality of medical care delivery in children with cancer and plan further development with consideration for the point elimination of existing defects. Objective. Our aim was to analyze the main indicators characterizing medical care for children with cancer in the North-West Federal District.Methods.The study analyzed operative reports for 2017 provided by the executive public health authorities of 11 subjects of the Russian Federation affiliated to the North-West Federal District.Results.The pediatric population was 2 537 133 children (0–17 years), the pediatric oncological bed capacity — 174 (0.7 per 10 000 aged 0–17 years), the annual berth average occupancy — 290.7 days. 6 (54.5%) subjects did not provide pediatric population with departments of pediatric oncology, 4 (36.4%) subjects did not have bed capacity. The number of practitioners providing medical care to children with cancer was 38, 27 among them (71%; 0.1 per 10 thousand 0–17 years) had a certificate of pediatric oncologist. 2 (18.2%) subjects did not have pediatric oncologists in the medical stuff. The incidence of malignant tumors in children aged 0–17 was 15.6 (per 100,000), the prevalence was 92.6 (per 100,000), the mortality rate was 2.6 (per 100,000), one-year mortality rate — 4.5% (18/397). The number of patients identified actively was 11 (2.8%). 160 (40.3%) primary patients were sent to Federal medical facilities, 6 (1.5%) — left the territory of the Russian Federation for the further treatment.Conclusion.The incidence and mortality rates are rather low which indicates the defects in patient detection and lack of reliable follow-up data. The percentage of patients referred for treatment to Federal medical facilities is not very high; however, to interpret this indicator according to patient routing, we have to analyze the medical history of all the patients. We can assert that health care delivery service for children with oncological diseases is at an acceptable standard level but needs to be improved. ","PeriodicalId":37249,"journal":{"name":"Onkopediatria","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41694772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Rykov, I. Turabov, Yuri A. Punanov, Svetlana Safonova
Background: Moscow and St. Petersburg are cities of federal significance with the largest number of children and consequently a large number of primary patients identified annually.Objective: Our aim was to analyze the main indicators characterizing the delivery of medical care for children with cancer in cities of federal significance.Methods: The operative reports for 2013–2017 of the Department of Health of Moscow, the Ministry of Health of the Moscow Region, the Health Committee of the Government of St. Petersburg, and the Health Committee of the Leningrad Region were analyzed.Results. In 2013–2017 in the Russian Federation, 18 090 primary patients were identified, 2734 (15.1%) of them in the analyzed subjects: in Moscow — 1315 (7.3%), in the Moscow Region — 492 (2.7%), in St. Petersburg — 697 (3.9%), in the Leningrad Region — 230 (1.3%). For 5 years, the number of primary patients increased in Moscow by 18.1%, in St. Petersburg — by 36%, in the Leningrad Region — by 2.5%. In the Moscow Region, the number of primary patients decreased by 2.3%. The incidence in Moscow increased by 5.3% (from 11.3 per 100 000 of children aged 0–17 in 2013 to 11.9 in 2017), in St. Petersburg — by 18.1% (from 14.9 in 2013 to 17.6 in 2017). The incidence in the Moscow Region fell by 20% (from 11.8 in 2013 to 9.4 in 2017), in the Leningrad Region by 4.9% (from 14.4 in 2013 to 13.7 in 2017). Mortality in 2016–2017 in Moscow decreased by 37.5% (from 6.4 per 100 thousand children’s population 0–17 years to 4), in the Moscow Region — by 50% (from 2 to 1), in St. Petersburg increased by 50% (from 2 to 3), in the Leningrad Region — by 12.5% (from 2.4 to 2.7). The one-year mortality rate in Moscow increased by 3.7% (from 8.3% in 2016 to 12% in 2017), in the Moscow Region — by 3.5% (from 5.4 to 8.9% %), in St. Petersburg — by 3.9% (from 2.5 to 6.4%). In the Leningrad Region, the one-year mortality rate decreased from 6.5% in 2016 to 0 in 2017. The number of pediatric oncological beds did not change in the Moscow Region (0.4 per 10,000 children aged 0–17 years), St. Petersburg (0.9), and the Leningrad Region (0). In Moscow and St. Petersburg patients were not identified actively in 2016–2017; in the Moscow Region, their percentage decreased from 34.2 to 7.3, in the Leningrad Region — from 8.7 to 0. In Moscow, the number of pediatric oncological beds increased by 50% (from 0.6 to 0.9). The number of oncologists increased in the Moscow Region from 0.009 per 10 000 children aged 0–17 years to 0.06 (66.7%), in St. Petersburg from 0.09 to 0.12 (+33.3%), in the Leningrad Region — from 0 to 0.03. In Moscow, the number of pediatric oncologists decreased from 0.13 to 0.11 (-15.3%).Conclusion: Defects of statistical data were revealed. Patients were not identified during routine preventive examinations which indicate a low oncologic alertness of district pediatric physicians. Delivery of medical care for children with cancer and the statistical data accumulation procedures should be
{"title":"Cities of Federal Significance: Analysis of the Main Indicators Characterizing Medical Care for Children with Cancer in 2013–2017. An Ecological Study","authors":"M. Rykov, I. Turabov, Yuri A. Punanov, Svetlana Safonova","doi":"10.15690/ONCO.V5I2.1911","DOIUrl":"https://doi.org/10.15690/ONCO.V5I2.1911","url":null,"abstract":"Background: Moscow and St. Petersburg are cities of federal significance with the largest number of children and consequently a large number of primary patients identified annually.Objective: Our aim was to analyze the main indicators characterizing the delivery of medical care for children with cancer in cities of federal significance.Methods: The operative reports for 2013–2017 of the Department of Health of Moscow, the Ministry of Health of the Moscow Region, the Health Committee of the Government of St. Petersburg, and the Health Committee of the Leningrad Region were analyzed.Results. In 2013–2017 in the Russian Federation, 18 090 primary patients were identified, 2734 (15.1%) of them in the analyzed subjects: in Moscow — 1315 (7.3%), in the Moscow Region — 492 (2.7%), in St. Petersburg — 697 (3.9%), in the Leningrad Region — 230 (1.3%). For 5 years, the number of primary patients increased in Moscow by 18.1%, in St. Petersburg — by 36%, in the Leningrad Region — by 2.5%. In the Moscow Region, the number of primary patients decreased by 2.3%. The incidence in Moscow increased by 5.3% (from 11.3 per 100 000 of children aged 0–17 in 2013 to 11.9 in 2017), in St. Petersburg — by 18.1% (from 14.9 in 2013 to 17.6 in 2017). The incidence in the Moscow Region fell by 20% (from 11.8 in 2013 to 9.4 in 2017), in the Leningrad Region by 4.9% (from 14.4 in 2013 to 13.7 in 2017). Mortality in 2016–2017 in Moscow decreased by 37.5% (from 6.4 per 100 thousand children’s population 0–17 years to 4), in the Moscow Region — by 50% (from 2 to 1), in St. Petersburg increased by 50% (from 2 to 3), in the Leningrad Region — by 12.5% (from 2.4 to 2.7). The one-year mortality rate in Moscow increased by 3.7% (from 8.3% in 2016 to 12% in 2017), in the Moscow Region — by 3.5% (from 5.4 to 8.9% %), in St. Petersburg — by 3.9% (from 2.5 to 6.4%). In the Leningrad Region, the one-year mortality rate decreased from 6.5% in 2016 to 0 in 2017. The number of pediatric oncological beds did not change in the Moscow Region (0.4 per 10,000 children aged 0–17 years), St. Petersburg (0.9), and the Leningrad Region (0). In Moscow and St. Petersburg patients were not identified actively in 2016–2017; in the Moscow Region, their percentage decreased from 34.2 to 7.3, in the Leningrad Region — from 8.7 to 0. In Moscow, the number of pediatric oncological beds increased by 50% (from 0.6 to 0.9). The number of oncologists increased in the Moscow Region from 0.009 per 10 000 children aged 0–17 years to 0.06 (66.7%), in St. Petersburg from 0.09 to 0.12 (+33.3%), in the Leningrad Region — from 0 to 0.03. In Moscow, the number of pediatric oncologists decreased from 0.13 to 0.11 (-15.3%).Conclusion: Defects of statistical data were revealed. Patients were not identified during routine preventive examinations which indicate a low oncologic alertness of district pediatric physicians. Delivery of medical care for children with cancer and the statistical data accumulation procedures should be ","PeriodicalId":37249,"journal":{"name":"Onkopediatria","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41917576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vidmante V. Daylidite, G. Mentkevich, I. Dolgopolov, N. Subbotina, A. Popa, A. Levashov, S. Babelyan, V. K. Boyarshinov, S. Zagidullina
Background. Despite current treatment regimens prognosis for high-risk medulloblastoma (MB) is still unfavorable. High dose chemotherapy (HDCT) with autologous stem cell transplantation (ASCT) may improve results.Objective. Our aim was to evaluate the outcomes in children over 3 years with high-risk MB who underwent high dose chemotherapy with thiotepa and ASCT.Methods. We investigated the therapy results in 23 children older than 3 years who received treatment at Russian Cancer Research Centre (Moscow) between January 2013 and December 2017. At consolidation stage they received tandem thiotepa at a dose 300 mg/m2 days -4, -3 and carboplatin at a dose 510 mg/m2 days -4, -3 followed by ASCT. 3 patients failed to undergo the second HDCT course for severe toxic complications.Results. As a result of treatment, 14 patients (60.9%) achieved complete remission, 9 patients (39.2%) had partial response. Treatment mortality rate was 8.6%. The level of 4-year survival was achieved: event-free survival (EFS), overall survival (OS), and disease free survival (DFS) rates were 59%±14%, 68.9%±12.3%, and 69.2%±15.6%, respectively. The worst results were registered in patients with metastatic tumor: 4-year EFS was 64.3%±12% versus patients with M0 stage - 80%±8.9%. Conclusion: Presented intensive treatment with moderate toxicity improves outcomes in poor prognosis patients over 3 years.
{"title":"High Dose Thiotepa with Autologous Stem Cell Transplantation in Children over 3 Years with High-Risk Medulloblastoma: Retrospective Cohort Study","authors":"Vidmante V. Daylidite, G. Mentkevich, I. Dolgopolov, N. Subbotina, A. Popa, A. Levashov, S. Babelyan, V. K. Boyarshinov, S. Zagidullina","doi":"10.15690/onco.v5i2.1913","DOIUrl":"https://doi.org/10.15690/onco.v5i2.1913","url":null,"abstract":"Background. Despite current treatment regimens prognosis for high-risk medulloblastoma (MB) is still unfavorable. High dose chemotherapy (HDCT) with autologous stem cell transplantation (ASCT) may improve results.Objective. Our aim was to evaluate the outcomes in children over 3 years with high-risk MB who underwent high dose chemotherapy with thiotepa and ASCT.Methods. We investigated the therapy results in 23 children older than 3 years who received treatment at Russian Cancer Research Centre (Moscow) between January 2013 and December 2017. At consolidation stage they received tandem thiotepa at a dose 300 mg/m2 days -4, -3 and carboplatin at a dose 510 mg/m2 days -4, -3 followed by ASCT. 3 patients failed to undergo the second HDCT course for severe toxic complications.Results. As a result of treatment, 14 patients (60.9%) achieved complete remission, 9 patients (39.2%) had partial response. Treatment mortality rate was 8.6%. The level of 4-year survival was achieved: event-free survival (EFS), overall survival (OS), and disease free survival (DFS) rates were 59%±14%, 68.9%±12.3%, and 69.2%±15.6%, respectively. The worst results were registered in patients with metastatic tumor: 4-year EFS was 64.3%±12% versus patients with M0 stage - 80%±8.9%. Conclusion: Presented intensive treatment with moderate toxicity improves outcomes in poor prognosis patients over 3 years.","PeriodicalId":37249,"journal":{"name":"Onkopediatria","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45327460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background. Currently, vascular access is one of the most important aspects in specific and accompanying treatment of cancer patients regardless of their age and sex. Partially implanted venous catheters previously described by Hickman were widely applied all over the world. The introduction of completely implanted venous port-systems revolutionized health care delivery and improved the quality of life in patients with oncological diseases. A fully implanted venous port consists of a silicone catheter which distal tip is connected to a port tank implanted subcutaneously. Such a design allows providing safe and multiple adequate vascular accesses regardless of the patient’s clinical state.Case Report. We present a clinical case of a 10-year-old patient diagnosed with medulloblastoma of the cerebellopontine angle and the left cerebellar hemisphere. The case described spontaneous detachment of an implanted venous port catheter and its migration to the venous heart in a patient who underwent chemotherapy by venous access provided through implantation of the venous port.Conclusion. Our clinical case demonstrated a rare and potentially extremely dangerous noninfectious complication associated with the use of venous port-systems. Implanted systems require washing 1–2 times per month with heparinized solutions or solutions containing taurolidine when they are not used. Periodic chest radiographs can reveal integrity alterations of the system. Any implanted system should be removed when it is not used, or it should be monitored on a regular basis.
{"title":"Spontaneous Catheter Separation from the Implanted Venous Port and Its Migration to the Venous Heart: Clinical Case","authors":"L. Olkhova, V. Popov","doi":"10.15690/ONCO.V5I2.1915","DOIUrl":"https://doi.org/10.15690/ONCO.V5I2.1915","url":null,"abstract":"Background. Currently, vascular access is one of the most important aspects in specific and accompanying treatment of cancer patients regardless of their age and sex. Partially implanted venous catheters previously described by Hickman were widely applied all over the world. The introduction of completely implanted venous port-systems revolutionized health care delivery and improved the quality of life in patients with oncological diseases. A fully implanted venous port consists of a silicone catheter which distal tip is connected to a port tank implanted subcutaneously. Such a design allows providing safe and multiple adequate vascular accesses regardless of the patient’s clinical state.Case Report. We present a clinical case of a 10-year-old patient diagnosed with medulloblastoma of the cerebellopontine angle and the left cerebellar hemisphere. The case described spontaneous detachment of an implanted venous port catheter and its migration to the venous heart in a patient who underwent chemotherapy by venous access provided through implantation of the venous port.Conclusion. Our clinical case demonstrated a rare and potentially extremely dangerous noninfectious complication associated with the use of venous port-systems. Implanted systems require washing 1–2 times per month with heparinized solutions or solutions containing taurolidine when they are not used. Periodic chest radiographs can reveal integrity alterations of the system. Any implanted system should be removed when it is not used, or it should be monitored on a regular basis.","PeriodicalId":37249,"journal":{"name":"Onkopediatria","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48948744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background. Planning the management for medical care delivery for children with cancer, as well as analysis of the effectiveness of medical care delivery is based on the statistical indicators analysis.Objective. Our aim was to analyze the main indicators characterizing medical care delivery for children with cancer in the Central Federal District.Methods. The operative reports for 2017 provided by the executive health protection authorities of 18 subjects of the Russian Federation that are part of the Central Federal District have been analyzed.Results. The study enrolled the following data: number of children was 6 824 049 (0–17 years), pediatric oncological departments — 9, pediatric oncological beds — 464, days of berth employment per year — 319.3. The number of practitioners providing medical care to children with cancer was 91, 64 (70.3%) of them had a certificate of training as a pediatric oncologist. In 11 subjects, the department of pediatric oncology was not available; one of the districts did not provide any pediatric oncological beds. The number of primary patients with malignant neoplasms was 821. The number of deceased patients was 156 including 66 identified in 2017. The incidence of malignant tumors was 12 (per 100 000 for the 0–17 age group), the mortality rate was 2.3 (per 100 thousand for the age group 0–17 years), one-year mortality rate — 8%. We failed to reveal the average time from diagnosis establishing till its validation before the treatment onset since the reports did not provide precise information on the point. 12 (1.5%) primary patients left for treatment abroad.Conclusion. Most reports included indicators which lack congruity with one another. The incidence rates were significantly lower than those in countries with high statistical reliability. The percentage of patients identified actively remained extremely low. To improve the revealed defects a single database of children with oncological diseases should be implemented in the Russian Federation.
{"title":"Analysis of Medical Care for Children with Cancer in the Central Federal District in 2017: Ecological Study","authors":"M. Rykov","doi":"10.15690/ONCO.V5I2.1910","DOIUrl":"https://doi.org/10.15690/ONCO.V5I2.1910","url":null,"abstract":"Background. Planning the management for medical care delivery for children with cancer, as well as analysis of the effectiveness of medical care delivery is based on the statistical indicators analysis.Objective. Our aim was to analyze the main indicators characterizing medical care delivery for children with cancer in the Central Federal District.Methods. The operative reports for 2017 provided by the executive health protection authorities of 18 subjects of the Russian Federation that are part of the Central Federal District have been analyzed.Results. The study enrolled the following data: number of children was 6 824 049 (0–17 years), pediatric oncological departments — 9, pediatric oncological beds — 464, days of berth employment per year — 319.3. The number of practitioners providing medical care to children with cancer was 91, 64 (70.3%) of them had a certificate of training as a pediatric oncologist. In 11 subjects, the department of pediatric oncology was not available; one of the districts did not provide any pediatric oncological beds. The number of primary patients with malignant neoplasms was 821. The number of deceased patients was 156 including 66 identified in 2017. The incidence of malignant tumors was 12 (per 100 000 for the 0–17 age group), the mortality rate was 2.3 (per 100 thousand for the age group 0–17 years), one-year mortality rate — 8%. We failed to reveal the average time from diagnosis establishing till its validation before the treatment onset since the reports did not provide precise information on the point. 12 (1.5%) primary patients left for treatment abroad.Conclusion. Most reports included indicators which lack congruity with one another. The incidence rates were significantly lower than those in countries with high statistical reliability. The percentage of patients identified actively remained extremely low. To improve the revealed defects a single database of children with oncological diseases should be implemented in the Russian Federation.","PeriodicalId":37249,"journal":{"name":"Onkopediatria","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44447976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：