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Biomechanical modeling in surgical treatment of a patient with true lumbar spondylolisthesis 生物力学模型在真腰椎滑脱患者手术治疗中的应用
Q3 Medicine Pub Date : 2018-12-30 DOI: 10.14531/2018.4.87-94
А. Л. Кудяшев, Владимир Васильевич Хоминец, Андрей Васильевич Теремшонок, Е. Б. Нагорный, С. Ю. Стадниченко, А. В. Доль, Д. В. Иванов, И. В. Кириллова, Л. Ю. Коссович, А. Л. Ковтун
Objective. To assess the results of clinical approbation of individual finite-element biomechanical model of a patient’s spino-pelvic complex with subsequent modeling of the best option of surgical treatment. Material and Methods. A biomechanical modeling of changes in the sagittal profile of a patient with degenerative disease of the lumbosacral spine, bilateral spondylolysis, and unstable grade 2 spondylolisthesis of the L4 vertebra was performed. The developed biomechanical model made it possible to assess the characteristics of the stress-strain state of the spinal motion segments aroused due to development of the disease. Within the built biomechanical model of the patient’s spino-pelvic complex, a corrective operation was further modeled that assumed a preservation of harmonious profile of sagittal spino-pelvic relationships. Post-correction characteristics of the stress-strain state of spinal motion segments were studied and compared with preoperative parameters of the biomechanical model. Results. Using methods of biomechanics and computer modeling allowed to calculate the stress-strain state of the lumbosacral spine under static load for two options of fixation and intervertebral cage implantation at the L4–L5 level: four transpedicular screws (L4–L5 vertebrae) and six transpedicular screws (L3–L4–L5 vertebrae). The simulation results showed that neither metal implants, nor elements of the lumbosacral spine experienced critical stresses and deformations that could lead to the destruction and instability of the implant. Conclusion. The developed individual biomechanical finite-element solid model of the spine and pelvis allowed for biomechanical justification of prerequisites for the formation and further progression of degenerative changes in spinal motion segments associated with violations of the sagittal profile due to grade 2 spondylolisthesis of the L4 vertebra. The model built on the results of radiological examination biomechanically substantiated the best option of corrective spine surgery allowing to minimize stresses and deformations by choosing reasonable magnitude of correction of sagittal spino-pelvic parameters and configuration of transpedicular system.
客观的评估患者脊柱-骨盆复合体的个体有限元生物力学模型的临床认可结果,以及随后的最佳手术治疗选择模型。材料和方法。对一名腰骶椎退行性疾病、双侧峡部裂和L4脊椎不稳定2级滑脱患者的矢状面变化进行生物力学建模。所开发的生物力学模型使评估由于疾病发展而引起的脊柱运动节段的应力-应变状态特征成为可能。在建立的患者脊柱-骨盆复合体的生物力学模型中,进一步对矫正手术进行了建模,假设矢状位脊柱-骨盆关系保持和谐。研究了脊柱运动节段矫正后应力应变状态的特征,并与生物力学模型的术前参数进行了比较。后果使用生物力学和计算机建模的方法,可以在L4–L5水平上计算两种固定和椎间盘植入方案在静载荷下腰骶棘的应力-应变状态:四个经椎弓根螺钉(L4–L6椎骨)和六个经椎弓根螺丝(L3–L4–L4椎骨)。模拟结果表明,无论是金属植入物,还是腰骶棘的元件,都没有经历可能导致植入物破坏和不稳定的临界应力和变形。结论所开发的脊柱和骨盆的个体生物力学有限元实体模型允许生物力学证明脊柱运动节段退行性变化的形成和进一步发展的先决条件,这些变化与L4脊椎2级滑脱引起的矢状面侵犯有关。基于放射学检查结果建立的模型从生物力学角度证实了脊柱矫正手术的最佳选择,通过选择合理的矢状棘骨-骨盆参数和经椎弓根系统配置的矫正幅度,可以最大限度地减少应力和变形。
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引用次数: 1
Injuries to the thoracolumbar junction: bibliometric analysis of English-language literature 胸腰椎交界处损伤:英文文献的文献计量学分析
Q3 Medicine Pub Date : 2018-12-04 DOI: 10.14531/2018.4.52-69
S. Likhachev, V. Zaretskov, A. Shulga, Svetlana Anfasovna Gramma, I. Shchanitsyn, S. Bazhanov, A. V. Zaretskov, A. M. Donnik
Objective. To analyze the 50 most cited articles related to the diagnosis, classification and surgical treatment of injuries of the thoracolumbar junction, which influenced the study of this problem. Material and Methods. The Web of Science database was searched for keywords to detect articles related to thoracolumbar junction surgery. Articles were selected taking into account the title, abstract and the used methods, and then evaluated by the total number of citations to identify the fifty most cited. Characteristics of publications were analyzed. Results. The United States of America, Thomas Jefferson University and A.R. Vaccaro were the most productive country, institution and author, respectively, dealing with the subject. The 2000s was the most active decade in terms of the number of publications. The greatest attention of scientists dealing with the problems of thoracolumbar injury was attracted by the article by McLain et al. analyzing the causes of the failures of short-segment transpedicular systems in the early postoperative period. The article by Laursen et al. presenting the results of using recombinant bone morphogenetic protein-7 in combination with metal fixation is at the top of the list in terms of average citation index. Most articles are well-designed randomized studies with the evidence level II. Conclusion. Citation analysis allowed to identify the most relevant articles, the authors of which have made a significant contribution to the problem of surgery of the thoracolumbar junction. Study of the information field through the prism of the most cited articles allows seeing the mainstream and future development of diagnostics, classification and treatment of the injuries of this localization.
客观的分析50篇被引用最多的关于胸腰椎交界处损伤的诊断、分类和外科治疗的文章,这些文章对该问题的研究产生了影响。材料和方法。在Web of Science数据库中搜索关键词,以检测与胸腰椎交界处手术相关的文章。文章的选择考虑了标题、摘要和使用的方法,然后根据引用总数进行评估,以确定被引用最多的50篇。分析了出版物的特点。后果美利坚合众国、托马斯·杰斐逊大学和A.R.Vaccaro分别是处理这一问题最富有成效的国家、机构和作者。就出版物数量而言,2000年代是最活跃的十年。研究胸腰椎损伤问题的科学家们最为关注的是McLain等人的文章。分析了短节段经椎弓根系统在术后早期失败的原因。Laursen等人的文章介绍了将重组骨形态发生蛋白-7与金属固定结合使用的结果,这篇文章在平均引用指数方面位居榜首。大多数文章都是精心设计的证据水平为II的随机研究。结论引文分析可以确定最相关的文章,这些文章的作者对胸腰椎交界处的手术问题做出了重大贡献。通过引用最多的文章来研究信息领域,可以看到这种定位损伤的诊断、分类和治疗的主流和未来发展。
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引用次数: 4
Experimental substantiation of osteotransplant application in traumatic vertebral defects 骨移植治疗外伤性椎体缺损的实验证实
Q3 Medicine Pub Date : 2018-12-04 DOI: 10.14531/2018.4.41-51
V. Rerikh, Yu. A. Predein, A. Zaidman, A. Lastevsky, V.A. Bataev V.A. Bataev V.A. Bataev, A. Nikulina
Objective. To analyze the features of bone tissue formation during plasty of vertebral body defect or fracture with an allogeneic bone graft in an experiment in vitro. Material and Methods. Models of the vertebral body defect (fracture of the cranioventral part with penetration into the nucleus pulposus) were created in an experiment on 20 mini-pigs of the same age. Plasty of traumatic defects was performed with allogeneic bone graft or autologous bone. CT, histological, and spectrometric studies of microscopic specimens were carried out at 14, 30, 90, and 180 day. Reparative osteogenesis, X-ray density, Ca and P content, and microhardness were studied. Results. After implantation of allogeneic bone graft, an organ-specific bone similar to the recipient’s bone in morphological structure, X-ray density, mineral composition and microhardness, was formed on the 90th day (P = 0.01). After transplantation of autobone, the regenerate formed by this day in the central part was in a phase of resorption and restructuring with lower indices of X-ray density, content of Ca and P, and microhardness (P = 0.01). Conclusion. Аfter plasty of vertebral body traumatic defects with allogeneic bone graft, the organ-specific bone tissue is formed at an earlier time and reliably exhibits greater mineralization and strength.
客观的在体外实验中分析同种异体骨移植在椎体缺损或骨折成形过程中骨组织形成的特点。材料和方法。在20只同龄的小型猪身上进行的实验中,建立了椎体缺损(穿透髓核的颅腹侧骨折)的模型。外伤性骨缺损的整形采用同种异体骨移植或自体骨。在第14、30、90和180天对显微镜标本进行CT、组织学和光谱研究。对修复性成骨、X射线密度、钙磷含量及显微硬度进行了研究。后果同种异体骨移植后,第90天形成与受体骨形态结构、X射线密度、矿物成分和显微硬度相似的器官特异性骨(P=0.01),Ca、P含量及显微硬度(P=0.01)。А用同种异体骨移植修复椎体创伤缺损后,器官特异性骨组织形成得更早,可靠地表现出更大的矿化度和强度。
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引用次数: 1
Anterior correction of angular kyphosis in children: description of the technique and analysis of clinical series 儿童角型后凸的前路矫正:技术描述及临床资料分析
Q3 Medicine Pub Date : 2018-12-04 DOI: 10.14531/2018.4.15-20
A. Mushkin, D. Naumov, V. Zorin, M. Serdobintsev
Objective. To describe the original technical surgical procedure simplifying the correction of kyphosis in children due to instrumental distraction of the anterior column of the spine, to analyze its effectiveness in the setting of clinical series. Level of evidence – IV. Material and Methods. The study included 9 patients aged 7 months to 14 years (median age: 4 years 8 months) with angular kyphosis (median magnitude 53°, min – 38°, max – 80°) associated with tuberculous (n = 4) and non-specific (n = 4) spondylitis and with a sequelae of spinal cord injury (n = 1). Deformity correction was achieved using temporary instrumental interbody distraction followed by anterior fusion with titanium mesh cage filled with autologous bone graft during a single-step two-stage reconstruction and stabilization surgery. Results. The duration of surgery was 3 hours 2 min ± 44 min, the volume of blood loss – 190 ml ± 39 ml. In all cases, the deformity was corrected by 75–85 % with restoration of physiological thoracic kyphosis and spinal profile. Conclusion. A safe and effective technique for intraoperative anterior instrumental distraction can be used to correct angular kyphosis in children, including infants.
目标。描述一种简化儿童脊柱前柱工具性牵张后凸矫正的原始技术手术方法,并分析其在临床系列设置中的有效性。证据水平- IV.材料和方法。该研究纳入9例患者,年龄7个月至14岁(中位年龄:4年8个月),伴有结核性脊柱炎(n = 4)和非特异性脊柱炎(n = 4)以及脊髓损伤后遗症(n = 1)的角型后凸(中位角53°,最小角- 38°,最大角- 80°)。在单步两阶段重建和稳定手术中,采用临时器械椎间撑开,然后用钛网笼填充自体骨移植物进行前路融合,实现了畸形矫正。结果。手术时间为3小时2分钟±44分钟,失血量- 190毫升±39毫升。所有病例的畸形矫正率为75 - 85%,恢复了生理性胸后凸和脊柱轮廓。结论。一种安全有效的术中前路器械牵张技术可用于矫正儿童(包括婴儿)的角型后凸。
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引用次数: 0
Surgical treatment of severe congenital kyphosis in an adult patient: rare clinical observation and a brief literature review 成人严重先天性后凸畸形的外科治疗:罕见的临床观察和文献综述
Q3 Medicine Pub Date : 2018-12-04 DOI: 10.14531/2018.4.21-26
Вячеслав Викторович Новиков, Александр Юрьевич Сергунин, Вадим Васильевич Белозеров, Майя Николаевна Лебедева, Александр Сергеевич Васюра, Михаил Витальевич Михайловский
The paper presents a clinical case of surgical treatment of an adult patient with severe rigid congenital kyphosis developed due to multiple anomalies in the thoracolumbar spine. Surgical intervention included vertebral column resection (VCR) and the deformity correction using segmental third-generation instrumentation with transpedicular fixation. The VCR made it possible to correct the relationship between vertebrae in the anomaly zone, to improve the shape of the spinal canal and increase its volume, and to achieve apparent mobility of the spine at the apex of the kyphosis. Preservation of the anterosuperior portion of the body of the resected vertebra allowed avoiding anterior mesh cage use to support and reconstruct the anterior supporting column of the resected segment. This enabled performing necessary correction of severe kyphotic deformity, reduced the risk of neurological complications, and favored the formation of solid bone block in the long-term period after surgery.
本文介绍了一例成年患者的手术治疗,该患者因胸腰椎多处异常而出现严重的先天性后凸。手术干预包括脊柱切除术(VCR)和使用第三代节段内固定器经椎弓根固定的畸形矫正术。VCR可以纠正异常区椎骨之间的关系,改善椎管的形状并增加其体积,并在后凸顶点实现脊柱的明显活动性。保留切除椎骨的身体前上部分可以避免使用前网笼来支撑和重建切除节段的前支撑柱。这使得能够对严重的后凸畸形进行必要的矫正,降低了神经系统并发症的风险,并有利于在手术后的长期内形成实心骨块。
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引用次数: 1
Vertebral syndrome in consequences of spina bifida: clinical features and treatment 脊柱裂后果中的椎体综合征:临床特征和治疗
Q3 Medicine Pub Date : 2018-12-04 DOI: 10.14531/2018.4.107-114
S. Ryabykh, A. Mushkin, D. Savin
The guidelines for the evaluation and treatment of vertebral pathology in patients with the consequences of spina bifida are presented for discussion among professional groups before their adoption. The guidelines are based on the literature data and the authors’ own experience. The purpose of the study is algorithmization of treatment, the material is presented mainly in the form of tables
评估和治疗脊柱裂后果患者的椎体病理的指导方针在其采用之前提出供专业团体讨论。该指南是基于文献数据和作者自己的经验。本研究的目的是算法化处理,资料主要以表格的形式呈现
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引用次数: 1
Historical aspects of transpedicular fixation of the spine: literature review 脊柱经椎弓根固定的历史方面:文献综述
Q3 Medicine Pub Date : 2018-12-04 DOI: 10.14531/2018.4.95-106
S. Makarevich
The main historical aspects of the evolution of transpedicular fixation of the spine were analyzed according to the literature. The main historical stages in the development of transpedicular fixation of the spine were identified: vertebral screw fixation (King, 1944), pedicle screw plate system (Roy-Camille, 1970), external transpedicular fixation – Fixateur Externe (Magerl, 1977), internal transpedicular fixation – Fixateur Interne (Dick, 1982), transpedicular titanium implants (1987). They played a significant role in the formation of modern surgical technologies for posterior metallic osteosynthesis and the creation of multifunctional transpedicular fixation devices, which are now considered to be the gold standard of posterior fixation for various pathologies of the thoracic, lumbar and lumbosacral spine.
根据文献分析了脊柱经椎弓根固定演变的主要历史方面。确定了脊柱经椎弓根固定发展的主要历史阶段:椎弓根螺钉固定(King, 1944),椎弓根螺钉钢板系统(Roy-Camille, 1970),经椎弓根外固定- Fixateur Externe (Magerl, 1977),经椎弓根内固定- Fixateur Interne (Dick, 1982),经椎弓根钛植入物(1987)。他们在后路金属骨固定的现代外科技术的形成和多功能经椎弓根固定装置的创造中发挥了重要作用,这些装置现在被认为是胸椎、腰椎和腰骶椎各种疾病后路固定的金标准。
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引用次数: 2
Interrelation of tropism and angulation parameters of facet joints and results of stabilization surgeries for degenerative diseases of the lumbar spine 腰椎退行性疾病小关节的向性和成角参数与稳定手术结果的关系
Q3 Medicine Pub Date : 2018-12-04 DOI: 10.14531/2018.4.70-79
V. Byvaltsev, A. K. Okoneshnikova, A. Kalinin, S. S. Rabinovich
Objective. To clarify indications for dynamic and rigid stabilization based on the analysis of correlation between neuroimaging parameters of facet joints (FJ) and clinical outcomes of surgical treatment of patients with degenerative diseases of the lumbar spine. Material and Methods. A total of 141 patients with degenerative diseases of the lumbar spine were surgically treated. Patients were divided into three groups: patients of Group I (n = 48) underwent surgical intervention with artificial intervertebral disc prosthesis; those of Group II (n = 42) – with interbody fusion and combined transpedicular and transfacetal stabilization; and those of Group III (n = 51) – with interbody fusion and bilateral transpedicular stabilization. The correlation between long-term clinical outcomes (pain syndrome according to VAS, functional state according to ODI, and satisfaction with surgical result according to MacNab scale) and preoperative neuroimaging parameters of FJ (degenerative changes according to Fujiwara, facet angle magnitudes, and the presence of tropism) was analyzed. Results. A direct significant nonparametric correlation of neuroimaging parameters of facet angles and FJ tropism with long-term clinical outcomes of surgical treatment according to VAS and ODI was revealed. It was established that good clinical outcomes were achieved with the following preoperative parameters: in Group I, the facet angle was less than 60°, while the presence of tropism had no correlation dependence; in Group II, the facet angle – more than 60°, in the absence of FJ tropism; and in Group III, the facet angle – more than 60°, in the presence of FJ tropism. Conclusion. Objective neuroimaging parameters of the facet angle magnitude of less than 60°, regardless of the presence of tropism, allow performing total arthroplasty. If the facet angle is more than 60°, the rigid stabilization of the operated segment is indicated; in the absence of tropism, a contralateral transfacetal fixation is possible, and in its presence – a bilateral transpedicular stabilization is reasonable.
目标。通过分析腰椎退行性疾病患者椎突关节(FJ)神经影像学参数与手术治疗临床结果的相关性,明确动态和刚性稳定的适应证。材料和方法。141例腰椎退行性疾病患者接受手术治疗。患者分为三组:I组患者(n = 48)行人工椎间盘假体手术干预;II组(n = 42) -椎间融合及经椎弓根和经颅联合稳定;III组(n = 51) -椎间融合和双侧经椎弓根稳定。分析FJ的长期临床结局(VAS评分为疼痛综合征,ODI评分为功能状态,MacNab评分为手术结果满意度)与术前神经影像学参数(Fujiwara评分为退行性改变,小关节角大小,有无向性)的相关性。结果。根据VAS和ODI显示,小关节角和FJ向性的神经影像学参数与手术治疗的长期临床结果有直接显著的非参数相关性。通过以下术前参数,我们可以获得良好的临床结果:第一组,关节突角小于60°,而向性的存在没有相关性依赖;第二组,关节突角大于60°,无FJ向性;在第三组,关节突角大于60°,存在FJ向性。结论。目的神经影像学参数的小关节面角度大小小于60°,无论是否存在向性,允许进行全关节置换术。如果关节面角度大于60°,则表示操作节段的刚性稳定;在无向性的情况下,对侧经颅固定是可能的,在有向性时,双侧经椎弓根稳定是合理的。
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引用次数: 1
Surgical treatment of craniovertebral stenosis in patients with mucopolysaccharidosis type I, II, and VI 粘多糖病I、II、VI型颅椎狭窄的手术治疗
Q3 Medicine Pub Date : 2018-12-04 DOI: 10.14531/2018.4.32-40
S. Mironov, S. Kolesov, V. Pereverzev, D. A. Kolbovsky, A. A. Kuleshov, M. S. Vetrile, A. I. Kazmin
To analyze surgical treatment of craniovertebral stenosis in patients with mucopolysaccharidosis. Material and Methods. A total of 9 patients (4 men, 5 women) with mucopolysaccharidosis were operated on for craniovertebral stenosis in 2012–2017. All patients underwent clinical examination, standard radiography of the cervical spine with functional tests to assess atlantooccipital stability according to Rothman, and MRI to determine the degree of the spinal cord compression, stenosis of the spinal canal, and changes in soft tissues surrounding the spinal canal due to fibrosis and accumulation of glycosaminoglycans. Maximum stenosis at the C0–C2 level was noted in 5 patients, at C1–C2 in 2, at C2–C4 in 1, and at C0–C1 in 1. Myelopathy in the upper cervical spine was detected in five cases. The overall somatic and functional statuses, as well as neurological parameters were assessed. Follow-up examination and X-ray examination were performed at 3, 6 and 12 months after surgery, and further every 6 months. Results. The average follow-up period was 2.5 years. The age of the patients varied from 1.8 to 34 years. After 3, 6, and 12 months after surgery, instrumentation was radiologically stable in all cases, there were no bone resorption signs around the elements of instrumentation. Seven patients showed a regression of neurologic symptoms and positive dynamics in the somatic status according to the assessment scales. In one patient, the neurological status remained unchanged. In one case, a temporary deterioration in the condition was noted after a failed intubation attempt, which required emergency tracheostomy, and operation was postponed to a later date to stabilize the condition. Complications after surgical treatment were observed in five patients. In one case, pseudoarthrosis, rod fracture, and instrumentation instability developed 1.5 years after the intervention, and revision surgery was required. Wound healing problems were observed in three patients and a liquorrhea in the early postoperative period, which was stopped without revision intervention – in one case. Conclusion. Decompression and stabilization in patients with mucopolysaccharidosis should be performed in advance, before any neurological disorder development. Fixation is required to prevent the development of instability, post-laminectomy deformities, and progression of cicatricial stenosis. Timely initiation of enzyme-replacement therapy improves the results of mucopolysaccharidosis treatment.
目的:探讨粘多糖病并发颅椎狭窄的外科治疗方法。材料和方法。2012-2017年共有9例(男4例,女5例)因颅椎狭窄行粘多糖病手术治疗。所有患者均接受了临床检查、标准颈椎x线片和功能检查,根据Rothman评估寰枕稳定性,并进行MRI检查,以确定脊髓受压程度、椎管狭窄程度以及因纤维化和糖胺聚糖积累引起的椎管周围软组织改变。5例患者在C0-C2处出现最大狭窄,C1-C2处2例,C2-C4处1例,C0-C1处1例。在5例中发现上颈椎脊髓病。评估整体的躯体和功能状态,以及神经参数。术后3、6、12个月进行随访检查和x线检查,每6个月随访一次。结果。平均随访时间为2.5年。患者年龄从1.8岁到34岁不等。术后3、6、12个月,所有病例的内固定物影像学稳定,内固定物周围无骨吸收征象。根据评估量表,7例患者表现出神经系统症状的消退和躯体状态的积极动态。其中一名患者的神经系统状态保持不变。在一个病例中,在插管失败后发现病情暂时恶化,需要紧急气管切开术,手术被推迟到较晚的日期以稳定病情。手术治疗后出现并发症5例。其中一例在干预后1.5年出现假关节、棒骨折和内固定不稳定,需要进行翻修手术。3例患者观察到伤口愈合问题,术后早期出现了脓口,其中1例在没有翻修干预的情况下停止了脓口。结论。粘多糖病患者的减压和稳定应在任何神经系统疾病发展之前提前进行。需要固定以防止不稳定的发展,椎板切除术后畸形和瘢痕性狭窄的进展。及时开始酶替代治疗可改善粘多糖病的治疗效果。
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引用次数: 2
Lesion of the craniovertebral junction in ankylosing spondylitis: rare clinical observations 强直性脊柱炎颅椎交界处病变:罕见的临床观察
Q3 Medicine Pub Date : 2018-12-04 DOI: 10.14531/2018.4.27-31
I. Lisitsky, А. М. Kiselev
Two cases of surgical treatment for lesions of the craniovertebral junction in patients with ankylosing spondylitis accompanied by severe neurological symptoms are described. Patients underwent one-step combined interventions. The first stage included occipitospondylodesis using screw instrumentation, and the second – transoral removal of the C2 odontoid process. Surgical treatment resulted in elimination of the spinal cord compression, regression of neurological deficit existed in patients before surgery, and achievement of stable fixation in the intervention area.
本文描述了两例强直性脊柱炎伴严重神经系统症状的颅椎交界处病变的外科治疗。患者接受一步联合干预。第一阶段包括用螺钉固定枕骨椎体,第二阶段经口切除C2齿状突。手术治疗消除了脊髓压迫,患者术前存在的神经功能缺损得到恢复,干预区得到稳定固定。
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引用次数: 0
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Hirurgia Pozvonochnika
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