This article introduces plastic surgeons' various roles in managing diabetic foot ulcers. The role of plastic surgeons is multidimensional and, of course, challenging. Sometimes, the healing process of diabetic ulcer is as simple as only adequate wound care. Sometimes, the ulcer needs reconstruction through a skin graft or flap coverage. Unfortunately, some patients need amputation or disarticulation. Again, plastic surgeons are maximizing patients' future movement ability in the case of amputation. Thus, an experienced plastic surgeon can provide an optimum lifestyle to the diabetic patient. TAJ 2022; 36: No-1: 55-61
本文介绍整形外科医生在治疗糖尿病足溃疡中的各种作用。整形外科医生的角色是多方面的，当然也是具有挑战性的。有时，糖尿病溃疡的愈合过程很简单，只需适当的伤口护理。有时，溃疡需要通过皮肤移植或皮瓣覆盖重建。不幸的是，有些病人需要截肢或截肢。再一次，整形外科医生在截肢的情况下最大限度地提高病人未来的活动能力。因此，经验丰富的整形外科医生可以为糖尿病患者提供最佳的生活方式。泰姬酒店2022;36: no - 1:55 -61
{"title":"Role of Plastic Surgery in the Management of Diabetic Foot Ulcer","authors":"Most Afroza Nazneen, Mohammad Ali Choudhury","doi":"10.3329/taj.v36i1.68283","DOIUrl":"https://doi.org/10.3329/taj.v36i1.68283","url":null,"abstract":"This article introduces plastic surgeons' various roles in managing diabetic foot ulcers. The role of plastic surgeons is multidimensional and, of course, challenging. Sometimes, the healing process of diabetic ulcer is as simple as only adequate wound care. Sometimes, the ulcer needs reconstruction through a skin graft or flap coverage. Unfortunately, some patients need amputation or disarticulation. Again, plastic surgeons are maximizing patients' future movement ability in the case of amputation. Thus, an experienced plastic surgeon can provide an optimum lifestyle to the diabetic patient. \u0000TAJ 2022; 36: No-1: 55-61","PeriodicalId":373921,"journal":{"name":"TAJ: Journal of Teachers Association","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127153443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Ara, L. Sharmin, F. Begum, Sanchita Sarker, M. B. Hossain, S. Yeasmin, Md Sanaul Haque Mia
Introduction: Community-acquired pneumonia (CAP) top the list of causes of under-five children mortality worldwide. Therefore, properly assessing and controlling these risk factors may help decrease the morbidity and mortality in under-five children suffering from CAP in Bangladesh and thereby help improve the quality of life of our future generation. Objective: To assess the risk factors of CAP among under-five children ( 2-59 months ) in a tertiary-level hospital in Rajshahi. Materials and methods: This case-control study was carried out in the Department of Pediatrics and EPI Center of Rajshahi Medical College Hospital, RMCH, from January 2017 to December 2018 to determine the risk factors of CAP among children under five. For this study, 246 children aged two months to 59 months were selected by purposive sampling. One hundred twenty-three were cases that were taken indoors, and 123 were healthy controls taken from the outpatient department & EPI center. After taking written consent from guardians, history was taken, and a physical examination was done. All information was recorded in a predesigned data sheet. The chi-square test and odds ratio were used to demonstrate significance. Results: Among 246 children, more patients of both groups were male and came from rural areas. Cases were predominantly under 12 months and came from lower socioeconomic status. A statistically significant association was found between social class and CAP (<0.001); the father's literacy was inversely related to CAP (p-value <0.001). Types of housing, living room ventilation, overcrowding, fuel and cookers used for cooking, parental smoking, malnutrition, history of diarrhea and presence of anemia, prematurity, and low birth weight were significantly associated with CAP (p-value <0.05). Conclusion: Proper assessment of these risk factors and controlling them may help decrease the morbidity and mortality in under-five children suffering from CAP in Bangladesh and thereby help improve the quality of life of our future generation. TAJ 2022; 36: No-1: 23-31
社区获得性肺炎(CAP)是全球五岁以下儿童死亡的首要原因。因此，适当评估和控制这些风险因素可能有助于降低孟加拉国五岁以下儿童患CAP的发病率和死亡率，从而有助于改善我们下一代的生活质量。目的:探讨拉杰沙希市某三级医院5岁以下儿童(2-59个月)CAP发生的危险因素。材料与方法:本病例对照研究于2017年1月至2018年12月在拉杰沙希医学院附属医院儿科和EPI中心开展，旨在确定5岁以下儿童CAP的危险因素。本研究采用目的抽样的方法，选取246名2 ~ 59月龄儿童。其中123例为室内病例，123例为门诊和EPI中心健康对照。在获得监护人的书面同意后，记录病史，并进行身体检查。所有信息都记录在预先设计的数据表中。采用卡方检验和优势比证明显著性。结果:246例患儿中，两组均以男性为主，且多来自农村地区。病例主要在12个月以下，来自较低的社会经济地位。社会阶层与CAP之间存在统计学显著相关(<0.001);父亲文化水平与CAP呈负相关(p值<0.001)。住房类型、客厅通风、过度拥挤、用于烹饪的燃料和炊具、父母吸烟、营养不良、腹泻史和贫血、早产和低出生体重与CAP显著相关(p值<0.05)。结论:正确评估和控制这些危险因素可能有助于降低孟加拉国五岁以下儿童CAP的发病率和死亡率，从而有助于提高我们下一代的生活质量。泰姬酒店2022;36: no - 1:23 -31
{"title":"Risk Factors of Community-Acquired Pneumonia Among Under-Five Children in a Tertiary Level Hospital in Rajshahi","authors":"C. Ara, L. Sharmin, F. Begum, Sanchita Sarker, M. B. Hossain, S. Yeasmin, Md Sanaul Haque Mia","doi":"10.3329/taj.v36i1.68276","DOIUrl":"https://doi.org/10.3329/taj.v36i1.68276","url":null,"abstract":"Introduction: Community-acquired pneumonia (CAP) top the list of causes of under-five children mortality worldwide. Therefore, properly assessing and controlling these risk factors may help decrease the morbidity and mortality in under-five children suffering from CAP in Bangladesh and thereby help improve the quality of life of our future generation. \u0000Objective: To assess the risk factors of CAP among under-five children ( 2-59 months ) in a tertiary-level hospital in Rajshahi. \u0000Materials and methods: This case-control study was carried out in the Department of Pediatrics and EPI Center of Rajshahi Medical College Hospital, RMCH, from January 2017 to December 2018 to determine the risk factors of CAP among children under five. For this study, 246 children aged two months to 59 months were selected by purposive sampling. One hundred twenty-three were cases that were taken indoors, and 123 were healthy controls taken from the outpatient department & EPI center. After taking written consent from guardians, history was taken, and a physical examination was done. All information was recorded in a predesigned data sheet. The chi-square test and odds ratio were used to demonstrate significance. \u0000Results: Among 246 children, more patients of both groups were male and came from rural areas. Cases were predominantly under 12 months and came from lower socioeconomic status. A statistically significant association was found between social class and CAP (<0.001); the father's literacy was inversely related to CAP (p-value <0.001). Types of housing, living room ventilation, overcrowding, fuel and cookers used for cooking, parental smoking, malnutrition, history of diarrhea and presence of anemia, prematurity, and low birth weight were significantly associated with CAP (p-value <0.05). \u0000Conclusion: Proper assessment of these risk factors and controlling them may help decrease the morbidity and mortality in under-five children suffering from CAP in Bangladesh and thereby help improve the quality of life of our future generation. \u0000TAJ 2022; 36: No-1: 23-31","PeriodicalId":373921,"journal":{"name":"TAJ: Journal of Teachers Association","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129949033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Md. Ruhul Amin, Al Mirajun Hoque, Marufa Hussain, Partho Moni Bhattacharyya, Md Amzad Hossain Sardar, Md Aminul Hasan, M. J. Alam
Background: In developing countries, pregnancy-associated acute kidney injury (PAAKI) is a significant cause of maternal and neonatal mortality and morbidity. A systematic evaluation is essential to understand its frequency and severity in our setting. Objectives: Primary aim of our study was to evaluate the epidemiological profile and outcome of patients with pregnancy-associated acute kidney injury. Patients and Methods: The study was conducted in the Department of Nephrology, Rajshahi medical college hospital, from January 2019 to March 2020. A total of 83 patients with pregnancy-associated acute kidney injury were evaluated. Patients who had a history of chronic kidney disease or were diagnosed as a case of chronic kidney disease were excluded from the study. Result: The mean age±SD was 25.39±5.90 years. The majority were <30 years of age (56.6%). Only 24.1% had completed regular antenatal checkups. Preeclamsic toxaemia was present in 10.8% of patients. 85.5% of delivery was performed at hospitals/ clinics, and 75.9% of delivery was done by cesarean section. Unskilled birth attendants did 9.7% of delivery. Anaemia was present in 41.0% of patients at presentation, and 67.5% received a blood transfusion. Maternal mortality was 32.5%, and neonatal mortality was 21.7%. Renal replacement therapy was given in 56 (67.5%) patients. Among them, 47 (83.9%) received hemodialysis. Common causes of pregnancy-associated acute kidney injury were found to be sepsis (77.1%), postpartum hemorrhage (41.0%), disseminated intravascular coagulation (21.7%), severe preeclampsia (16.9%), HELLP syndrome (2.4%) and transfusion reaction (7.2%). 31.4% of patients recovered completely, and 10.8% of patients developed chronic kidney disease. Conclusion: Providing good quality perinatal care is essential to reduce the frequency of pregnancy-associated acute kidney injury and maternal and neonatal mortality related to this. TAJ 2022; 36: No-1: 127-134
背景:在发展中国家，妊娠相关急性肾损伤(PAAKI)是孕产妇和新生儿死亡和发病的重要原因。一个系统的评估是必要的，以了解其频率和严重程度在我们的设置。目的:本研究的主要目的是评估妊娠相关急性肾损伤患者的流行病学概况和预后。患者和方法:研究于2019年1月至2020年3月在Rajshahi医学院附属医院肾内科进行。本文对83例妊娠相关性急性肾损伤患者进行了评价。有慢性肾脏疾病病史或被诊断为慢性肾脏疾病的患者被排除在研究之外。结果:平均年龄±SD为25.39±5.90岁。以<30岁者居多(56.6%)。只有24.1%的人完成了定期的产前检查。10.8%的患者存在子痫前期毒血症。85.5%的分娩在医院/诊所进行，75.9%的分娩通过剖宫产完成。不熟练的助产士接生了9.7%。41.0%的患者出现贫血，67.5%的患者接受了输血。产妇死亡率为32.5%，新生儿死亡率为21.7%。56例(67.5%)患者接受肾脏替代治疗。其中47例(83.9%)接受了血液透析。妊娠相关急性肾损伤常见原因为败血症(77.1%)、产后出血(41.0%)、弥漫性血管内凝血(21.7%)、重度子痫前期(16.9%)、HELLP综合征(2.4%)和输血反应(7.2%)。31.4%的患者完全康复，10.8%的患者发展为慢性肾脏疾病。结论:提供高质量的围产期护理对降低妊娠相关性急性肾损伤发生率和与此相关的孕产妇和新生儿死亡率至关重要。泰姬酒店2022;36: no - 1:27 -134
{"title":"Epidemiological Profile and Outcome of Pregnancy Associated Acute Kidney Injury","authors":"Md. Ruhul Amin, Al Mirajun Hoque, Marufa Hussain, Partho Moni Bhattacharyya, Md Amzad Hossain Sardar, Md Aminul Hasan, M. J. Alam","doi":"10.3329/taj.v36i1.68322","DOIUrl":"https://doi.org/10.3329/taj.v36i1.68322","url":null,"abstract":"Background: In developing countries, pregnancy-associated acute kidney injury (PAAKI) is a significant cause of maternal and neonatal mortality and morbidity. A systematic evaluation is essential to understand its frequency and severity in our setting. Objectives: Primary aim of our study was to evaluate the epidemiological profile and outcome of patients with pregnancy-associated acute kidney injury. Patients and Methods: The study was conducted in the Department of Nephrology, Rajshahi medical college hospital, from January 2019 to March 2020. A total of 83 patients with pregnancy-associated acute kidney injury were evaluated. Patients who had a history of chronic kidney disease or were diagnosed as a case of chronic kidney disease were excluded from the study. \u0000Result: The mean age±SD was 25.39±5.90 years. The majority were <30 years of age (56.6%). Only 24.1% had completed regular antenatal checkups. Preeclamsic toxaemia was present in 10.8% of patients. 85.5% of delivery was performed at hospitals/ clinics, and 75.9% of delivery was done by cesarean section. Unskilled birth attendants did 9.7% of delivery. Anaemia was present in 41.0% of patients at presentation, and 67.5% received a blood transfusion. Maternal mortality was 32.5%, and neonatal mortality was 21.7%. Renal replacement therapy was given in 56 (67.5%) patients. Among them, 47 (83.9%) received hemodialysis. Common causes of pregnancy-associated acute kidney injury were found to be sepsis (77.1%), postpartum hemorrhage (41.0%), disseminated intravascular coagulation (21.7%), severe preeclampsia (16.9%), HELLP syndrome (2.4%) and transfusion reaction (7.2%). 31.4% of patients recovered completely, and 10.8% of patients developed chronic kidney disease. \u0000Conclusion: Providing good quality perinatal care is essential to reduce the frequency of pregnancy-associated acute kidney injury and maternal and neonatal mortality related to this. \u0000TAJ 2022; 36: No-1: 127-134","PeriodicalId":373921,"journal":{"name":"TAJ: Journal of Teachers Association","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114080496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Kabir, Md Abdul Latif Khan, Md. Shirajul Islam Khan, A. Karim, Md. Mustafizur Rahman, A. Jamil
Background: Tinea pedis is a dermatophytosis of the feet usually occurs between the toes with the webspace between the fourth and fifth digits but, in many cases, may appear as an extensive pattern on the bottom and sides of the feet. Terbinafine and itraconazole were evaluated with the efficacy/effectiveness and toxicity in the systemic treatment of Tinea pedis and compared with each other. Objective: To compare the efficacy and safety of terbinafine vs. itraconazole in treating tinea pedis. Materials and Methods: A total of 50 patients were selected, and they were divided into groups (group-A and group B), each of which included 25 patients. Group A was given oral Terbinafine 250 mg daily for two weeks. Group B was given oral Itraconazole 200mg daily for the same duration. Patients were observed for the efficacy and side effects of the trial medicines. A baseline complete blood picture, liver and renal function test, and urine analysis were done and repeated frequently during therapy. Results: Most patients were in the fourth decade in both groups, and the male-to-female ratio was almost 4:1. Two groups of people were studied: group-A with terbinafine 250 mg daily and group B with itraconazole 200 mg daily for 14 days. Evaluated weekly during treatment and 02 weeks after cessation of therapy, and finally on 08th week to see the clinical improvement and adverse effects. The clinical response was found in chronic hyperkeratotic type: 08/08, 08/08; chronic interdigital type: 07/07, 07/06; vesico-bullous type: 06/05, 06/05; Mixed type: 04/03, 03/02 in group-A and group-B respectively. On average, 92% clinical improvement was found in group-A and 84% in group B. Most patients had nausea (20.0%) followed by 08% diarrhea in group A. On the other hand, in group B, most patients had nausea (28.0%), followed by 4.0% fatigue and 4.0% diarrhea, and only 01 patient found elevated liver enzyme but did not exceed the upper limit. 80% of patients in the terbinafine group had transient, mild to moderate nausea. Conclusion: No significant differences in efficacy and toxicity were found between terbinafine and itraconazole groups. Terbinafine may represent a good alternative for treating Tinea Pedis in patients who cannot take itraconazole or other available drugs due to contraindications. TAJ 2022; 36: No-1: 75-82
{"title":"Study on Efficacy and Safety of Terbinafine Vs. Itraconazole in the Treatment of Tinea Pedis","authors":"M. Kabir, Md Abdul Latif Khan, Md. Shirajul Islam Khan, A. Karim, Md. Mustafizur Rahman, A. Jamil","doi":"10.3329/taj.v36i1.68302","DOIUrl":"https://doi.org/10.3329/taj.v36i1.68302","url":null,"abstract":"Background: Tinea pedis is a dermatophytosis of the feet usually occurs between the toes with the webspace between the fourth and fifth digits but, in many cases, may appear as an extensive pattern on the bottom and sides of the feet. Terbinafine and itraconazole were evaluated with the efficacy/effectiveness and toxicity in the systemic treatment of Tinea pedis and compared with each other. Objective: To compare the efficacy and safety of terbinafine vs. itraconazole in treating tinea pedis. \u0000Materials and Methods: A total of 50 patients were selected, and they were divided into groups (group-A and group B), each of which included 25 patients. Group A was given oral Terbinafine 250 mg daily for two weeks. Group B was given oral Itraconazole 200mg daily for the same duration. Patients were observed for the efficacy and side effects of the trial medicines. A baseline complete blood picture, liver and renal function test, and urine analysis were done and repeated frequently during therapy. \u0000Results: Most patients were in the fourth decade in both groups, and the male-to-female ratio was almost 4:1. Two groups of people were studied: group-A with terbinafine 250 mg daily and group B with itraconazole 200 mg daily for 14 days. Evaluated weekly during treatment and 02 weeks after cessation of therapy, and finally on 08th week to see the clinical improvement and adverse effects. The clinical response was found in chronic hyperkeratotic type: 08/08, 08/08; chronic interdigital type: 07/07, 07/06; vesico-bullous type: 06/05, 06/05; Mixed type: 04/03, 03/02 in group-A and group-B respectively. On average, 92% clinical improvement was found in group-A and 84% in group B. Most patients had nausea (20.0%) followed by 08% diarrhea in group A. On the other hand, in group B, most patients had nausea (28.0%), followed by 4.0% fatigue and 4.0% diarrhea, and only 01 patient found elevated liver enzyme but did not exceed the upper limit. 80% of patients in the terbinafine group had transient, mild to moderate nausea. \u0000Conclusion: No significant differences in efficacy and toxicity were found between terbinafine and itraconazole groups. Terbinafine may represent a good alternative for treating Tinea Pedis in patients who cannot take itraconazole or other available drugs due to contraindications. \u0000TAJ 2022; 36: No-1: 75-82","PeriodicalId":373921,"journal":{"name":"TAJ: Journal of Teachers Association","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124162074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Md. Jawadul Haque, F. Yasmin, Md Ashfaq Arif, N. Rahman, Rehana Parven, M. Asaduzzaman, Muhammad Zubayer Alam
Introduction: Healthcare-associated infections represent significant obstacles to providing high-quality healthcare and have been directly linked to ineffective infection control procedures. There is currently a shortage of trustworthy data in Bangladesh describing the epidemiology of hospital-acquired infections (HAIs), which is necessary for the development of effective infection prevention and control measures. This study's goal was to assess the frequency, nature, and risk factors of HAIs in acute care hospitals in Northern Bangladesh. Methods: This was a pilot point prevalent survey conducted in the medicine, surgery, gynecology, and obstetrics departments of Rajshahi Medical College Hospital between August 2022 to September 2022. Data were collected by two questionnaires for disease profile and hospital-acquired infection. In addition, a checklist was used for the observation of the infection prevention and control (IPC) status of different wards. Result: Approximately 900 patients' data were collected during this time period. The overall prevalence of HAI was found to be 3.7%. The prevalence of HAI, especially surgical site Infection (SSI), in the obstetrics ward, was 4.2%, and the Medicine ward was 3.9%, respectively. The prevalence of hospital-acquired infection in the surgery ward is 7.7%. Approximately 41.7% of patients developed SSI on the 6th post operative day (POD). The Infection prevention and control status of different wards was similar, which was not satisfactory. Conclusion: This surveillance might help concerned authorities and policymakers by making some crucial steps to monitor and reduce hospital-acquired infections and HAIs in hospitals. TAJ 2022; 36: No-1: 9-15
导言:医疗保健相关感染是提供高质量医疗保健的重大障碍，并与无效的感染控制程序直接相关。孟加拉国目前缺乏描述医院获得性感染流行病学的可靠数据，而这些数据对于制定有效的感染预防和控制措施是必要的。本研究的目的是评估孟加拉国北部急症医院HAIs的频率、性质和危险因素。方法:于2022年8月至2022年9月在拉杰沙希医学院附属医院内科、外科、妇科和产科进行试点点流行调查。通过疾病概况和医院获得性感染两份问卷收集数据。采用检查表对各病区感染防控(IPC)情况进行观察。结果:在此期间收集了大约900名患者的数据。总体HAI患病率为3.7%。产科病房和内科病房的HAI患病率分别为4.2%和3.9%，尤其是手术部位感染(SSI)。外科病房医院获得性感染患病率为7.7%。约41.7%的患者在术后第6天(POD)发生SSI。不同病区感染防控情况相似，存在不足。结论:该监测可以帮助有关当局和决策者采取一些关键步骤来监测和减少医院获得性感染和HAIs。泰姬酒店2022;36: no - 1:9 -15
{"title":"Point-Prevalence Survey for the Hospital-Acquired Infections and Infection Prevention and Control Status of Different Wards of Rajshahi Medical College Hospital","authors":"Md. Jawadul Haque, F. Yasmin, Md Ashfaq Arif, N. Rahman, Rehana Parven, M. Asaduzzaman, Muhammad Zubayer Alam","doi":"10.3329/taj.v36i1.68274","DOIUrl":"https://doi.org/10.3329/taj.v36i1.68274","url":null,"abstract":"Introduction: Healthcare-associated infections represent significant obstacles to providing high-quality healthcare and have been directly linked to ineffective infection control procedures. There is currently a shortage of trustworthy data in Bangladesh describing the epidemiology of hospital-acquired infections (HAIs), which is necessary for the development of effective infection prevention and control measures. This study's goal was to assess the frequency, nature, and risk factors of HAIs in acute care hospitals in Northern Bangladesh. \u0000Methods: This was a pilot point prevalent survey conducted in the medicine, surgery, gynecology, and obstetrics departments of Rajshahi Medical College Hospital between August 2022 to September 2022. Data were collected by two questionnaires for disease profile and hospital-acquired infection. In addition, a checklist was used for the observation of the infection prevention and control (IPC) status of different wards. \u0000Result: Approximately 900 patients' data were collected during this time period. The overall prevalence of HAI was found to be 3.7%. The prevalence of HAI, especially surgical site Infection (SSI), in the obstetrics ward, was 4.2%, and the Medicine ward was 3.9%, respectively. The prevalence of hospital-acquired infection in the surgery ward is 7.7%. Approximately 41.7% of patients developed SSI on the 6th post operative day (POD). The Infection prevention and control status of different wards was similar, which was not satisfactory. \u0000Conclusion: This surveillance might help concerned authorities and policymakers by making some crucial steps to monitor and reduce hospital-acquired infections and HAIs in hospitals. \u0000TAJ 2022; 36: No-1: 9-15","PeriodicalId":373921,"journal":{"name":"TAJ: Journal of Teachers Association","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125731345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Rashid, Md Shafiqul Islam, M. Parvin, A. Saifullah, B. C. Shil, Md. Habibur Rahman, Mst Musarrat Sultana
Background: Serum cholinesterase mainly comes from the liver, a sensitive indicator of the synthetic capacity of the liver. It can be used as a prognostic marker for cirrhosis. Objectives: To measure the serum cholinesterase level in cirrhotic patients and to correlate its level with the severity of the disease as per the Child-Pugh score. Methodology: This cross-sectional study was conducted in the Department of Gastroenterology, Sir Salimullah Medical College Mitford Hospital, Dhaka, Bangladesh, from January 2018 to December 2018. Fifty adult patients with cirrhosis of the liver were enrolled. Fifty healthy individuals were also taken to compare serum cholinesterase levels. Cirrhotic patients were grouped strictly into A, B, and C classes, as per the Child-Pugh score. Serum cholinesterase level was measured in all participants. The correlation between cholinesterase level and the severity of the disease was analyzed. Result: Mean age of the patients was 47.42 ± 12.40 years and 47.22 ± 11.99 years in cirrhotic patients and healthy group, respectively. The number of patients in the Child-Pugh A, B, and C subgroups was 12 (24%), 20 (40%), and 18 (36%), respectively. The mean serum cholinesterase level was 2938 ± 1561 U/L in cirrhotic patients and 9036 ± 2024 U/L in the healthy group. Serum cholinesterase level in different Child-Pugh class was 4740 ± 1046 U/l (Child A), 3157 ± 1161 U/l (Child B), and 1493 ± 500 U/l (Child C). Serum Cholinesterase was positively correlated with serum albumin and negatively correlated with bilirubin, prothrombin time, and INR. A negative correlation was found between serum Cholinesterase level and the severity of the disease. Conclusion: Serum cholinesterase level was low in cirrhotic patients, and its level was inversely correlated with the severity of the disease. Thus it can be used as a prognostic marker of cirrhosis. However, further study with a large sample size could explain this more precisely. TAJ 2022; 36: No-1: 33-40
{"title":"Serum Cholinesterase Level in Patients with Cirrhosis of Liver and Its Correlation with the Severity of the Disease","authors":"M. Rashid, Md Shafiqul Islam, M. Parvin, A. Saifullah, B. C. Shil, Md. Habibur Rahman, Mst Musarrat Sultana","doi":"10.3329/taj.v36i1.68279","DOIUrl":"https://doi.org/10.3329/taj.v36i1.68279","url":null,"abstract":"Background: Serum cholinesterase mainly comes from the liver, a sensitive indicator of the synthetic capacity of the liver. It can be used as a prognostic marker for cirrhosis. \u0000Objectives: To measure the serum cholinesterase level in cirrhotic patients and to correlate its level with the severity of the disease as per the Child-Pugh score. \u0000Methodology: This cross-sectional study was conducted in the Department of Gastroenterology, Sir Salimullah Medical College Mitford Hospital, Dhaka, Bangladesh, from January 2018 to December 2018. Fifty adult patients with cirrhosis of the liver were enrolled. Fifty healthy individuals were also taken to compare serum cholinesterase levels. Cirrhotic patients were grouped strictly into A, B, and C classes, as per the Child-Pugh score. Serum cholinesterase level was measured in all participants. The correlation between cholinesterase level and the severity of the disease was analyzed. \u0000Result: Mean age of the patients was 47.42 ± 12.40 years and 47.22 ± 11.99 years in cirrhotic patients and healthy group, respectively. The number of patients in the Child-Pugh A, B, and C subgroups was 12 (24%), 20 (40%), and 18 (36%), respectively. The mean serum cholinesterase level was 2938 ± 1561 U/L in cirrhotic patients and 9036 ± 2024 U/L in the healthy group. Serum cholinesterase level in different Child-Pugh class was 4740 ± 1046 U/l (Child A), 3157 ± 1161 U/l (Child B), and 1493 ± 500 U/l (Child C). Serum Cholinesterase was positively correlated with serum albumin and negatively correlated with bilirubin, prothrombin time, and INR. A negative correlation was found between serum Cholinesterase level and the severity of the disease. \u0000Conclusion: Serum cholinesterase level was low in cirrhotic patients, and its level was inversely correlated with the severity of the disease. Thus it can be used as a prognostic marker of cirrhosis. However, further study with a large sample size could explain this more precisely. \u0000TAJ 2022; 36: No-1: 33-40","PeriodicalId":373921,"journal":{"name":"TAJ: Journal of Teachers Association","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124339765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Md Mottalib Hossain Khan, Md. Ahsanul Haque, F. Kabir, S. Nath, Rozina Aktar Zahan, N. Rahman
Background: Dermatophytes are the most significant fungi because of their widespread involvement in the population and their prevalence worldwide. Bangladesh's hot and humid climate, overcrowded population, poverty, malnutrition, and ignorance make dermatophytosis a common cutaneous infection. These infections occur in both healthy and immunocompromised patients. Dermatophytes are responsible for most cutaneous fungal infections, and the estimated lifetime risk of acquiring a dermatophyte infection is 10-20%. Objective: To isolate and identify different dermatophytes and their antifungal susceptibility pattern in the Rajshahi region. Materials and Methods: Different clinical samples (e.g., skin scrapings, nail clipping, and hair plucking) were collected under aseptic precautions. The isolation and identification of dermatophytes were performed through a microscopic examination using 10% KOH mount, mycological culture, and species identification by lactophenol cotton blue mount from positive culture. In addition, all dermatophytes isolates were subjected to antifungal susceptibility testing using the agar-based disk diffusion method in Mueller Hinton agar media. Results: Out of 171 samples, Trichophyton rubrum was the predominant dermatophyte species with 76(71.7%), followed by T.mentagrophyte were 15(14.2%), E. floccosum were 12(11.3%), and M. canis were 03(2.8%). voriconazole, clotrimazole, and itraconazole were more effective drugs. Griseofulvin was the least effective drug, followed by fluconazole. Conclusion: This study indicates dermatophytosis is a common skin disease in northern Bangladesh. Due to the increasing trend of antifungal drug resistance among dermatophytes, treatment should be based on antifungal sensitivity testing. TAJ 2022; 36: No-1: 119-125
背景:皮肤真菌是最重要的真菌，因为它们广泛存在于人群中并在世界范围内流行。孟加拉国炎热潮湿的气候、过度拥挤的人口、贫困、营养不良和无知使皮肤真菌病成为一种常见的皮肤感染。这些感染发生在健康和免疫功能低下的患者中。皮肤真菌是大多数皮肤真菌感染的原因，估计一生中感染皮肤真菌的风险为10-20%。目的:分离鉴定拉吉沙希地区不同类型的皮肤真菌及其抗真菌药敏规律。材料和方法:在无菌注意事项下收集不同的临床标本(如刮皮、剪指甲、拔毛)。采用10% KOH mount镜检、真菌学培养、阳性培养的乳酚棉蓝mount菌种鉴定等方法对皮肤真菌进行分离鉴定。此外，采用基于琼脂的圆盘扩散法在Mueller Hinton琼脂培养基中对所有分离的皮肤真菌进行抗真菌药敏试验。结果:171份样本中，以红毛癣菌76种(71.7%)为优势种，其次为芒植毛癣菌15种(14.2%)、絮凝毛癣菌12种(11.3%)、犬支原体03种(2.8%)。伏立康唑、克曲康唑和伊曲康唑疗效较好。灰黄霉素是效果最差的药物，其次是氟康唑。结论:本研究表明，皮肤真菌病是孟加拉国北部常见的皮肤病。由于皮肤真菌耐药呈上升趋势，治疗应以抗真菌药敏试验为基础。泰姬酒店2022;36: no - 1:19 19-125
{"title":"Prevalence of Dermatophytic Infections and Their Antifungal Susceptibility Pattern in the Rajshahi Region","authors":"Md Mottalib Hossain Khan, Md. Ahsanul Haque, F. Kabir, S. Nath, Rozina Aktar Zahan, N. Rahman","doi":"10.3329/taj.v36i1.68317","DOIUrl":"https://doi.org/10.3329/taj.v36i1.68317","url":null,"abstract":"Background: Dermatophytes are the most significant fungi because of their widespread involvement in the population and their prevalence worldwide. Bangladesh's hot and humid climate, overcrowded population, poverty, malnutrition, and ignorance make dermatophytosis a common cutaneous infection. These infections occur in both healthy and immunocompromised patients. Dermatophytes are responsible for most cutaneous fungal infections, and the estimated lifetime risk of acquiring a dermatophyte infection is 10-20%. \u0000Objective: To isolate and identify different dermatophytes and their antifungal susceptibility pattern in the Rajshahi region. Materials and Methods: Different clinical samples (e.g., skin scrapings, nail clipping, and hair plucking) were collected under aseptic precautions. The isolation and identification of dermatophytes were performed through a microscopic examination using 10% KOH mount, mycological culture, and species identification by lactophenol cotton blue mount from positive culture. In addition, all dermatophytes isolates were subjected to antifungal susceptibility testing using the agar-based disk diffusion method in Mueller Hinton agar media. \u0000Results: Out of 171 samples, Trichophyton rubrum was the predominant dermatophyte species with 76(71.7%), followed by T.mentagrophyte were 15(14.2%), E. floccosum were 12(11.3%), and M. canis were 03(2.8%). voriconazole, clotrimazole, and itraconazole were more effective drugs. Griseofulvin was the least effective drug, followed by fluconazole. \u0000Conclusion: This study indicates dermatophytosis is a common skin disease in northern Bangladesh. Due to the increasing trend of antifungal drug resistance among dermatophytes, treatment should be based on antifungal sensitivity testing. \u0000TAJ 2022; 36: No-1: 119-125","PeriodicalId":373921,"journal":{"name":"TAJ: Journal of Teachers Association","volume":"144 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129043956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The volumetric measurement of the maxillary sinuses is essential in assessing the incidence of sinusitis and cancer and measuring the intimate relationship between teeth and maxillary sinuses. There have been reports in multiple studies that there is racial variation concerning age and gender. This study aims to determine whether the sinus volume of males and females differ and its relation to age. Methods: This descriptive observational study was carried out among 100 respondents between the age of 11- 60 years who were residing in Rajshahi during the study period of one year, i.e., January 2018 to December 2018. The data has been collected from the Department of Radiology and Imaging of Rajshahi Medical College Hospital (RMCH) from the patients who had undergone CT scan examinations. The measurements were directly taken from a computer provided with an electronic caliper. After that, the sinus volume was calculated manually using the following formula (height x width x depth x 0.5). The quality of the data was obtained diligently, and ethical issues were properly maintained in all the steps of this study. Results: There were 50 males and 50 females, ranging from 11 – 60 years of age, where the mean (± SD) age was 36.7 (± 14.8) years. The mean (± SD) volume of the maxillary sinus in the male group was 17 (± 4.6) cm3 for the right side and 17.5 (± 4.7) cm3 for the left side, which was significantly more than the female group, 14.7 (± 3.7) cm3 for the right side and 15.1 (± 3.7) cm3 for the left side (p = 0.031). Concerning age, the distribution of maxillary sinus volume showed the highest values between 21-30 years of age, and then it decreased both on the right and left side; this finding was found to be statistically significant (p = 0 .018). Conclusion: This study provides salient information regarding maxillary sinus volume among the people of the Rajshahi district of Bangladesh. This study's results will help establish a reference dataset regarding anatomical measurements of the maxillary sinus. TAJ 2022; 36: No-1: 83-87
{"title":"CT Measurement of Maxillary Sinus Volume Among the Population of Rajshahi District in Bangladesh","authors":"Sadia Afrin, Dhm Fazle Rabbi, Rashed Mustafa, W. Ahmed, Akhtari Afroze","doi":"10.3329/taj.v36i1.68303","DOIUrl":"https://doi.org/10.3329/taj.v36i1.68303","url":null,"abstract":"Background: The volumetric measurement of the maxillary sinuses is essential in assessing the incidence of sinusitis and cancer and measuring the intimate relationship between teeth and maxillary sinuses. There have been reports in multiple studies that there is racial variation concerning age and gender. This study aims to determine whether the sinus volume of males and females differ and its relation to age. \u0000Methods: This descriptive observational study was carried out among 100 respondents between the age of 11- 60 years who were residing in Rajshahi during the study period of one year, i.e., January 2018 to December 2018. The data has been collected from the Department of Radiology and Imaging of Rajshahi Medical College Hospital (RMCH) from the patients who had undergone CT scan examinations. The measurements were directly taken from a computer provided with an electronic caliper. After that, the sinus volume was calculated manually using the following formula (height x width x depth x 0.5). The quality of the data was obtained diligently, and ethical issues were properly maintained in all the steps of this study. \u0000Results: There were 50 males and 50 females, ranging from 11 – 60 years of age, where the mean (± SD) age was 36.7 (± 14.8) years. The mean (± SD) volume of the maxillary sinus in the male group was 17 (± 4.6) cm3 for the right side and 17.5 (± 4.7) cm3 for the left side, which was significantly more than the female group, 14.7 (± 3.7) cm3 for the right side and 15.1 (± 3.7) cm3 for the left side (p = 0.031). Concerning age, the distribution of maxillary sinus volume showed the highest values between 21-30 years of age, and then it decreased both on the right and left side; this finding was found to be statistically significant (p = 0 .018). \u0000Conclusion: This study provides salient information regarding maxillary sinus volume among the people of the Rajshahi district of Bangladesh. This study's results will help establish a reference dataset regarding anatomical measurements of the maxillary sinus. \u0000TAJ 2022; 36: No-1: 83-87","PeriodicalId":373921,"journal":{"name":"TAJ: Journal of Teachers Association","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123764986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mita Rani Joysoual, Shahin Ara, Md. Nazmul Haque, R. Ghosh, T. Afroze, Saqib Salah Aufi
Background: Metformin is recommended as first-line pharmacotherapy for patients with type 2 Diabetes Mellitus (T2DM) who fail to achieve glycemic control through lifestyle modification. Metformin initially lowers blood glucose, but as diabetes progresses, it alone frequently fails to maintain glycemic control, and additional therapies are required. Empagliflozin is a potent and selective sodium-glucose co-transporter 2 (SGLT2) inhibitor that is effective in reducing blood sugar levels as monotherapy or add-on to existing therapy with significant improvements in glycemic control and weight. Materials & Methods: This quasi-experimental study was conducted in the Department of Pharmacology and Therapeutics in collaboration with Rajshahi Diabetic Association General Hospital, Rajshahi, for one year from January 2021 to December 2021 on 50 uncontrolled T2DM patients (glycosylated hemoglobin, HbA1c > 7.0 to ≤ 10.5%) for more than 12 weeks. The investigating drug, empagliflozin 10 mg (1 tablet) as a once-daily dose, was added to the ongoing treatment of each patient as 3rd line treatment and was followed up at 6 and 12 weeks. Results: The mean FBS at baseline was 10.8 mmol/L, which declined to 8.5 mmol/L at six weeks and then to 7.2 mmol/L after 12 weeks of intervention with Empagliflozin as add-on therapy in patients with uncontrolled T2DM. The overall reduction of FBS from baseline to 12 weeks of intervention was statistically significant (p < 0.001). Simultaneously the mean HbA1c also reduced from 9.4% to 7.7% after six weeks and to 7.1% after 12 weeks of intervention (p < 0.001). The mean systolic and diastolic blood pressures decreased from 129 mmHg to below 120 mmHg (p < 0.001) and 82.3 mmHg to below 80 mmHg (p = 0.029), respectively, after three months of intervention. Conclusion: Empagliflozin as add-on therapy responded well in patients with uncontrolled T2DM (previously treated with metformin combined with either sulfonylurea or DPP-4 inhibitors and/or supplemented by insulin) in achieving glycemic control. TAJ 2022; 36: No-1: 89-95
{"title":"Efficacy of Empagliflozin as Add-on Therapy in Patients with Uncontrolled Type 2 Diabetes Mellitus","authors":"Mita Rani Joysoual, Shahin Ara, Md. Nazmul Haque, R. Ghosh, T. Afroze, Saqib Salah Aufi","doi":"10.3329/taj.v36i1.68304","DOIUrl":"https://doi.org/10.3329/taj.v36i1.68304","url":null,"abstract":"Background: Metformin is recommended as first-line pharmacotherapy for patients with type 2 Diabetes Mellitus (T2DM) who fail to achieve glycemic control through lifestyle modification. Metformin initially lowers blood glucose, but as diabetes progresses, it alone frequently fails to maintain glycemic control, and additional therapies are required. Empagliflozin is a potent and selective sodium-glucose co-transporter 2 (SGLT2) inhibitor that is effective in reducing blood sugar levels as monotherapy or add-on to existing therapy with significant improvements in glycemic control and weight. \u0000Materials & Methods: This quasi-experimental study was conducted in the Department of Pharmacology and Therapeutics in collaboration with Rajshahi Diabetic Association General Hospital, Rajshahi, for one year from January 2021 to December 2021 on 50 uncontrolled T2DM patients (glycosylated hemoglobin, HbA1c > 7.0 to ≤ 10.5%) for more than 12 weeks. The investigating drug, empagliflozin 10 mg (1 tablet) as a once-daily dose, was added to the ongoing treatment of each patient as 3rd line treatment and was followed up at 6 and 12 weeks. \u0000Results: The mean FBS at baseline was 10.8 mmol/L, which declined to 8.5 mmol/L at six weeks and then to 7.2 mmol/L after 12 weeks of intervention with Empagliflozin as add-on therapy in patients with uncontrolled T2DM. The overall reduction of FBS from baseline to 12 weeks of intervention was statistically significant (p < 0.001). Simultaneously the mean HbA1c also reduced from 9.4% to 7.7% after six weeks and to 7.1% after 12 weeks of intervention (p < 0.001). The mean systolic and diastolic blood pressures decreased from 129 mmHg to below 120 mmHg (p < 0.001) and 82.3 mmHg to below 80 mmHg (p = 0.029), respectively, after three months of intervention. \u0000Conclusion: Empagliflozin as add-on therapy responded well in patients with uncontrolled T2DM (previously treated with metformin combined with either sulfonylurea or DPP-4 inhibitors and/or supplemented by insulin) in achieving glycemic control. \u0000TAJ 2022; 36: No-1: 89-95","PeriodicalId":373921,"journal":{"name":"TAJ: Journal of Teachers Association","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132346797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Ghosh, Rajeshwari Ghose, Md Rezaul Karim, Shahin Ara, Md Azizul Haque, Md. Nazmul Haque, Mita Rani Joysoual
Background: The study aimed to see the effectiveness and role of ivabradine on the quality of life in chronic heart failure suffering patients. This open-label Randomized controlled Trial was conducted to assess the effect of ivabradine plus conventional medical management over conventional medical management on quality-of-life parameters among 100 patients of chronic heart failure from January 2021 to December 2021 in the Department of Pharmacology & Therapeutics in collaboration with the Department of Cardiology & Medicine, Rajshahi Medical College Hospital, Rajshahi. Materials and methods: According to the drug allocation study population was divided into a control group (50 patients) and an experimental group (50 patients). Minnesota Living with Heart Failure questionnaire (MLWHFQ) was used to assess the quality of life, and the resting heart rate was measured by 12-lead electrocardiography. Baseline demographic and clinical characteristics were recorded, and patients were followed up at four weeks and 12 weeks of treatment. Results: The comparison of mean differences of MLWHFQ score at first and second follow-up visits between the two study groups was statistically significant [t (100) = 2.43 p < 0.05 & t (100) = 6.60 p < 0.001 respectively]. According to the MLWHFQ cut-point score, it was also observed that poor baseline quality of life gradually shifted to good quality after four weeks and 12 weeks of treatment, and it was proportionately higher in the experimental group. Relations between the respondents of both study groups and their different qualities of life during the first follow-up visit (x2 = 13.69, df = 2, p < 0.05) and second follow-up visit (x2 = 22.79, df = 2, p < 0.001) were statistically significant.The comparison of the mean (±SD) heart rate between the two study groups was statistically significant (p <0.001) only during the second follow-up visit. Conclusion: This study concluded that adding ivabradine to conventional medical management in treating patients with chronic heart failure improves their symptoms, quality of life, and heart rate and ultimately reduces the morbidity and mortality of such patients. TAJ 2022; 36: No-1: 1-8
背景:本研究旨在观察伊伐布雷定对慢性心力衰竭患者生活质量的影响及作用。本开放标签随机对照试验旨在评估伊伐布雷定加常规医疗管理对2021年1月至2021年12月期间在拉杰沙希医学院附属拉杰沙希医学院药理学与治疗学系合作的100例慢性心力衰竭患者生活质量参数的影响。材料与方法:根据药物分配将研究人群分为对照组(50例)和实验组(50例)。采用明尼苏达心力衰竭患者生活问卷(MLWHFQ)评估患者的生活质量，静息心率采用12导联心电图测量。记录基线人口统计学和临床特征，并在治疗4周和12周时对患者进行随访。结果:两组患者第一次和第二次随访时MLWHFQ评分的平均差异比较，差异均有统计学意义[t (100) = 2.43 p < 0.05 & t (100) = 6.60 p < 0.001]。根据MLWHFQ切割点评分，也观察到在治疗4周和12周后，较差的基线生活质量逐渐向较好的基线生活质量转变，实验组的基线生活质量比例较高。两组被调查者在第一次随访(x2 = 13.69, df = 2, p < 0.05)和第二次随访(x2 = 22.79, df = 2, p < 0.001)时的生活质量与生活质量的关系均有统计学意义。两个研究组的平均(±SD)心率只有在第二次随访时才有统计学意义(p <0.001)。结论:在常规医疗管理中加入伊伐布雷定可改善慢性心力衰竭患者的症状、生活质量和心率，最终降低慢性心力衰竭患者的发病率和死亡率。泰姬酒店2022;36: No-1: 1-8
{"title":"Comparison of Effect of Conventional Medical Management and Ivabradine with Conventional Medical Management on Quality of Life in Patients with Chronic Heart Failure","authors":"R. Ghosh, Rajeshwari Ghose, Md Rezaul Karim, Shahin Ara, Md Azizul Haque, Md. Nazmul Haque, Mita Rani Joysoual","doi":"10.3329/taj.v36i1.68273","DOIUrl":"https://doi.org/10.3329/taj.v36i1.68273","url":null,"abstract":"Background: The study aimed to see the effectiveness and role of ivabradine on the quality of life in chronic heart failure suffering patients. This open-label Randomized controlled Trial was conducted to assess the effect of ivabradine plus conventional medical management over conventional medical management on quality-of-life parameters among 100 patients of chronic heart failure from January 2021 to December 2021 in the Department of Pharmacology & Therapeutics in collaboration with the Department of Cardiology & Medicine, Rajshahi Medical College Hospital, Rajshahi. \u0000Materials and methods: According to the drug allocation study population was divided into a control group (50 patients) and an experimental group (50 patients). Minnesota Living with Heart Failure questionnaire (MLWHFQ) was used to assess the quality of life, and the resting heart rate was measured by 12-lead electrocardiography. Baseline demographic and clinical characteristics were recorded, and patients were followed up at four weeks and 12 weeks of treatment. \u0000Results: The comparison of mean differences of MLWHFQ score at first and second follow-up visits between the two study groups was statistically significant [t (100) = 2.43 p < 0.05 & t (100) = 6.60 p < 0.001 respectively]. According to the MLWHFQ cut-point score, it was also observed that poor baseline quality of life gradually shifted to good quality after four weeks and 12 weeks of treatment, and it was proportionately higher in the experimental group. Relations between the respondents of both study groups and their different qualities of life during the first follow-up visit (x2 = 13.69, df = 2, p < 0.05) and second follow-up visit (x2 = 22.79, df = 2, p < 0.001) were statistically significant.The comparison of the mean (±SD) heart rate between the two study groups was statistically significant (p <0.001) only during the second follow-up visit. \u0000Conclusion: This study concluded that adding ivabradine to conventional medical management in treating patients with chronic heart failure improves their symptoms, quality of life, and heart rate and ultimately reduces the morbidity and mortality of such patients. \u0000TAJ 2022; 36: No-1: 1-8","PeriodicalId":373921,"journal":{"name":"TAJ: Journal of Teachers Association","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115387020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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