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Patellofemoral Instability Secondary to Trochlear Dysplasia - A Case Report 髌骨股骨不稳继发于趾骨发育不良 - 病例报告
Q4 Medicine Pub Date : 2024-07-23 DOI: 10.4314/aas.v20i4.2
Timothy Kagoda Byakika, P. G. Mwawingwa
Patellofemoral joint instability is a debilitating condition that affects the biomechanical relationships between the soft tissues and the  bony architecture of the knee joint. Trochlear dysplasia is an identifiable etiology in 85-96% of patients with patellar instability.  Trochleoplasty is a surgical procedure that aims at restoring a sulcus or creating a near-normal trochlear deep enough to accommodate  the patellar in the trochlear groove, restoring patellofemoral congruence, patella tracking, and biomechanics during flexion and  extension. This case report describes a sulcus-deepening trochleoplasty through a superolateral parapatellar arthrotomy in a 15- year-old  adolescent who presented with a severe form of patellar instability due to trochlear dysplasia. 
髌股关节不稳定是一种影响膝关节软组织和骨结构之间生物力学关系的衰弱性疾病。85%-96%的髌骨不稳患者的病因可确定为趾骨发育不良。 蹄状沟成形术是一种外科手术,旨在恢复蹄状沟或创建一个接近正常的蹄状沟,其深度足以在蹄状沟中容纳髌骨,从而恢复髌股同形、髌骨跟踪以及屈伸时的生物力学。本病例报告描述了通过髌骨旁上外侧关节切开术,对一名因髌骨发育不良而导致严重髌骨不稳的15岁青少年进行的髌沟加深髌骨成形术。
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引用次数: 0
Status of Surgical Research and Publication in Africa 非洲外科研究与出版现状
Q4 Medicine Pub Date : 2024-07-23 DOI: 10.4314/aas.v21i1.1
Raju Vaishya, A. Vaish, James Kigera
Introduction: The research output in surgical branches such as orthopedics and sports medicine (OSM) is meager from Africa,  considering the population and the high burden of health-related problems. We conducted this study to analyze the trend of publications  in OSM from African countries and compared it with other surgical specialities. Methods: We used the SCOPUS data from  the Scimago Journal & Country Rank website, as it allows us to draw substantial journal metrics for research. Results: During the past  three decades (between 1996 and 2022), Africa’s global contribution to all surgical specialities has increased. In OSM, this was only 0.65%  in 1996 and had risen to 1.79% in 2022. The total publications in OSM were 8297 from 49 countries during this period. The number of  publications has risen from 61 (in 1996) to 931 (in 2022), with the maximum surge seen during the past decade. South Africa, Egypt, and  Tunisia are the leading African nations in OSM publications and have contributed 77% of the total publications from Africa in 2022. There  were only three orthopedic and four other surgical specialities indexed journals listed in the SCImago, arising from Africa. Conclusions:  There was an increased research output from Africa in OSM during 1996–2022, especially in the past decade. However, only three nations  have contributed more than three-fourth of these publications. There is a scarcity of indexed journals in the surgical disciplines arising  from Africa. 
导言:考虑到非洲的人口数量和健康相关问题的沉重负担,非洲在矫形外科和运动医学(OSM)等外科分支领域的研究成果很少。我们开展了这项研究,以分析非洲国家在骨科和运动医学领域发表论文的趋势,并将其与其他外科专业进行比较。研究方法:我们使用了 Scimago 期刊与国家排名网站上的 SCOPUS 数据,因为该网站允许我们得出实质性的期刊研究指标。结果过去三十年间(1996 年至 2022 年),非洲对全球所有外科专业的贡献都在增加。1996年,非洲在OSM中所占比例仅为0.65%,而到2022年,这一比例已上升至1.79%。在此期间,49 个国家共发表了 8297 篇 OSM 论文。出版物数量从 61 种(1996 年)上升到 931 种(2022 年),在过去十年中激增幅度最大。南非、埃及和突尼斯是发表 OSM 论文最多的非洲国家,占 2022 年非洲发表论文总数的 77%。在SCImago收录的期刊中,只有3种骨科和4种其他外科专业期刊来自非洲。结论: 1996-2022 年间,非洲在 OSM 方面的研究成果有所增加,尤其是在过去十年。然而,只有三个国家发表了超过四分之三的论文。非洲外科学科的索引期刊很少。
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引用次数: 0
Diffuse Aggressive Angiomyxoma of the Vulva: A Case Report 外阴弥漫性侵袭性血管瘤:病例报告
Q4 Medicine Pub Date : 2024-07-23 DOI: 10.4314/aas.v20i4.6
Asli Mohamed Abdullahi, Mohamed Abdullahi Awale, Bashiru Garba, Mariam Adawe, Fatima Ibrahim Nor, M. Kahiye
Aggressive angiomyxoma is a mesenchymal tumor that is frequently found in women of reproductive age mostly appearing in the vulva,  perineal region, head, neck, trunk, and lower limbs. A 33-year-old multiparous Somali woman presented to the outpatient department of Dr Sumait Hospital, with a complaint of swelling around her vulva. The patient reported that the mass had progressively grown for the  past 8 years and that she experienced stigma from her previous spouses. Her past medical history and socioeconomic status were unremarkable. During the physical examination, a welldefined pedunculated mass measuring 14 cm × 8 cm, originating from the labia  majora, was noted. The mass was pinkish, non-tender, non-reducible, and had a soft consistency. Some areas of ulceration measuring 2 cm × 2 cm, covered with necrotic granulation tissues, were also noticed. With the patient’s written informed consent, a biopsy was  performed, and the histopathology results revealed aggressive angiomyxoma. Following confirmation of the diagnosis, the mass was  surgically excised under sterile conditions and spinal anesthesia. Aggressive angiomyxoma is an important consideration when  evaluating vulvovaginal growth in females. Given its tendency for local recurrences, it is vital to establish an accurate diagnosis. 
侵袭性血管肌瘤是一种间叶肿瘤,常见于育龄妇女,多发于外阴、会阴部、头颈部、躯干和下肢。一名 33 岁的多产索马里妇女因外阴肿胀到苏迈特医生医院门诊部就诊。患者称,肿块在过去 8 年中逐渐增大,而且她的前配偶对她有成见。她的既往病史和社会经济状况均无异常。体格检查时,发现了一个界限清楚的蒂状肿块,大小为 14 厘米×8 厘米,源自大阴唇。肿块呈粉红色,无触痛,不可复发,质地柔软。此外,还发现一些面积为 2 厘米 × 2 厘米的溃疡,表面覆盖着坏死的肉芽组织。在征得患者书面知情同意后,医生对其进行了活检,组织病理学结果显示为侵袭性血管肌瘤。确诊后,在无菌条件和脊髓麻醉下对肿块进行了手术切除。在评估女性外阴阴道生长时,侵袭性血管瘤是一个重要的考虑因素。鉴于其局部复发的倾向,准确诊断至关重要。
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引用次数: 0
Adjunctive Uterine Incision Compression Versus Tourniquet Alone for Reduction of Blood Loss During Abdominal Myomectomy: A Randomized Controlled Trial 辅助子宫切口压迫与单用止血带减少腹部肌瘤切除术中的失血量:随机对照试验
Q4 Medicine Pub Date : 2024-07-23 DOI: 10.4314/aas.v21i1.4
J. Imaralu, O. Loto, Adebisi Florence Oguntade, O. Jagun, Taofeek Ogunfunmilayo, A. Akadri, Oladapo Walker
Introduction: The effectiveness of the uterine tourniquet alone for securing hemostasis during abdominal myomectomy remains  debatable; however, its combination with uterine compression though popular has very scanty documented evidence of hemostatic  efficacy. Aim: To determine the effect of uterine incision compression (UIC) combined with tourniquet on operative blood loss associated  with abdominal myomectomy. Materials and Methods: A multicenter randomized double blind, controlled trial involving 184  participants randomized into two groups: 92 in the UIC and 92 in the control arm. UIC was administered in the interval from release of  the uterine tourniquet to palpation of contraction. Data were analyzed using the Statistical Package for the Social Sciences (SPSS), version  21. Results: The mean intraoperative blood loss was lower in the UIC group (951.41 ± 362.32 mL) than in the control group  (1051.30 ± 427.77 mL), but did not reach statistical significance (p = 0.125). The observed mean duration of myomectomy was, however,  longer among the controls (152.95 ± 32.67 min, compared with 119.70 ± 23.96 min, p = 0.001). The control group also had significantly higher rates of deployment of additional hemostatic measures (OR = 4.68, 95% CI = 2.304–12.784, p = 0.001), occurrence of postoperative  pyrexia (OR = 1.65, 95% CI = 1.256–2.154, p = 0.002), and greater mean postoperative blood loss (p = 0.003). Conclusion: Although no  statistically significant difference occurred in intraoperative blood loss, adjunctive UIC was useful in reducing operating time and  postoperative blood loss 
导言:在腹部子宫肌瘤切除术中,单独使用子宫止血带止血的效果仍有待商榷;然而,将子宫止血带与子宫压迫术结合使用虽然很流行,但止血效果的文献证据却非常稀少。目的:确定子宫切口压迫(UIC)联合止血带对腹部子宫肌瘤切除术相关手术失血的影响。材料与方法:多中心随机双盲对照试验,将 184 名参与者随机分为两组:92 人参加子宫切口压力术,92 人参加对照组。从松开子宫止血带到触诊宫缩的间歇期进行 UIC。数据使用社会科学统计软件包(SPSS)第 21 版进行分析。结果UIC 组的术中平均失血量(951.41 ± 362.32 mL)低于对照组(1051.30 ± 427.77 mL),但未达到统计学意义(P = 0.125)。不过,观察到的子宫肌瘤切除术平均持续时间在对照组中更长(152.95 ± 32.67 分钟,而对照组为 119.70 ± 23.96 分钟,p = 0.001)。对照组采用额外止血措施(OR = 4.68,95% CI = 2.304-12.784,p = 0.001)、术后发热(OR = 1.65,95% CI = 1.256-2.154,p = 0.002)和术后平均失血量(p = 0.003)的比例也明显更高。结论虽然在术中失血量方面没有统计学意义上的显著差异,但辅助 UIC 有助于缩短手术时间和减少术后失血量
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引用次数: 0
Incidence and Severity of Erectile Dysfunction in Chronic Kidney Disease Patients Undergoing CAPD and Hemodialysis: A Systematic Review and Meta-analysis 接受 CAPD 和血液透析治疗的慢性肾病患者勃起功能障碍的发生率和严重程度:系统回顾与元分析
Q4 Medicine Pub Date : 2024-07-23 DOI: 10.4314/aas.v20i4.4
D. Dahril, Indrayudha Pramono
Background: Erectile dysfunction (ED) is an adverse effect of chronic kidney disease (CKD) treatment that can reduce patients’ quality of  life. Consequently, the purpose of this study is to assess the incidence and severity of ED in CKD patients who have undergone continuous ambulatory peritoneal dialysis (CAPD) and hemodialysis. Methods: We performed a systematic search on several electronic  reference databases (PubMed, ScienceDirect, Web of Science, and Cochrane). Inclusion criteria are articles published in English, full-text  availability, and articles published between 2001 and 2023. The reviewed studies were observational studies. The studies analyzed either CAPD or hemodialysis. Results: A total of 15 studies were included. ED in patients with CKD who had undergone CAPD and hemodialysis  varied, ranging from 51.84% to 80.5%and 56% to 89%, respectively. A pooled estimate showed that CKD patients who underwent  hemodialysis had higher odds of developing ED (odds ratio [OR]=12.56; 95% confidence interval [CI]=6.37–24.77; p<0.001) compared with  those who underwent CAPD (OR=8.02; 95%CI=1.64–39.15; p=0.01). Regarding the laboratory outcomes, no significant differences were  found in creatinine serum (MD= −1.08; 95%CI= −3.21 to 1.06; p=0.32) and hemoglobin levels (MD= −0.38; 95%CI= −1.05 to 0.30; p=0.27)  between CKD patients who underwent dialysis, either with or without ED. Conclusion: ED is prevalent among patients undergoing  hemodialysis. In addition, hemodialyzed patients exhibited more severe levels of ED compared with CAPD patients. Therefore, we suggest  CAPD for CKD patients with ED. 
背景:勃起功能障碍(ED)是慢性肾脏病(CKD)治疗的一种不良反应,会降低患者的生活质量。因此,本研究的目的是评估接受持续非卧床腹膜透析(CAPD)和血液透析治疗的 CKD 患者勃起功能障碍的发生率和严重程度。研究方法我们在多个电子参考数据库(PubMed、ScienceDirect、Web of Science 和 Cochrane)中进行了系统检索。纳入标准为:以英文发表的文章、全文可用性、2001 年至 2023 年间发表的文章。所审查的研究均为观察性研究。这些研究分析了 CAPD 或血液透析。结果:共纳入 15 项研究。接受过 CAPD 和血液透析的 CKD 患者的 ED 各不相同,分别从 51.84% 到 80.5% 和 56% 到 89% 不等。汇总估计结果显示,与接受 CAPD 的患者相比,接受血液透析的 CKD 患者发生 ED 的几率更高(几率比 [OR]=12.56; 95% 置信区间 [CI]=6.37-24.77; p<0.001)(OR=8.02; 95%CI=1.64-39.15; p=0.01)。在实验室结果方面,接受或不接受 ED 透析的 CKD 患者的血清肌酐(MD=-1.08;95%CI=-3.21 至 1.06;p=0.32)和血红蛋白水平(MD=-0.38;95%CI=-1.05 至 0.30;p=0.27)无明显差异。结论ED在接受血液透析的患者中很普遍。此外,与 CAPD 患者相比,血液透析患者表现出更严重的 ED。因此,我们建议患有 ED 的 CKD 患者接受 CAPD 治疗。
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引用次数: 0
A Clinical Audit of Post-Operative Outcomes of Laparoscopic Nissen’s Fundoplication in a Single Center in Sub-Saharan Africa 撒哈拉以南非洲单个中心腹腔镜尼森氏胃底折叠术术后效果临床审计
Q4 Medicine Pub Date : 2024-07-23 DOI: 10.4314/aas.v21i1.3
C. Munguti, Bernard Ndung'u
Introduction: Gastroesophageal reflux disease (GERD) is a common benign condition with a population prevalence of 18–28%.  Laparoscopic antireflux surgery is increasingly being offered to patients with GERD in our setting; however, the outcomes remain  unknown. Methodology: A retrospective clinical audit of patients who underwent laparoscopic Nissen’s fundoplication in a single center.  Data were summarized as mean (±SD) and median (interquartile range [IQR]); associations were analyzed with Chi square or Fischer’s  exact test. A Modified Visick scoring system was used to assess the severity of symptoms after surgery. Regression models were used to  analyze the factors associated with recurrence. Kaplan–Meier plots were plotted, and cox regression models, hazard ratio, and their  confidence intervals were calculated. Results: A total of 127 patients were identified, with 6 having had previous laparoscopic Nissen’s  fundoplication. Post-operative modified Visick scores at 2 weeks and 3 months were 1.04 (±0.05) and 1.03 (±0.04), respectively, for both typical and atypical symptoms. The recurrence rate was 12.6%, with 87.4% 5-year recurrence-free survival. Conclusion: Laparoscopic  Nissen’s fundoplication provides good control of both typical and atypical GERD symptoms with a low recurrence rate and a 5- year  recurrence-free survival that is comparable to universal rates.
简介胃食管反流病(GERD)是一种常见的良性疾病,在人群中的发病率为 18-28%。 在我国,越来越多的胃食管反流病患者接受腹腔镜抗反流手术治疗,但其疗效仍不得而知。方法:对在一个中心接受腹腔镜尼森胃底折叠术的患者进行回顾性临床审计。 数据以平均值(±SD)和中位数(四分位数间距 [IQR])汇总;相关性用智平方或费舍尔精确检验进行分析。采用改良维西克评分法评估术后症状的严重程度。回归模型用于分析与复发相关的因素。绘制了 Kaplan-Meier 图,并计算了 cox 回归模型、危险比及其置信区间。结果共确定了 127 名患者,其中 6 人曾接受过腹腔镜尼森氏胃底折叠术。术后2周和3个月的典型和非典型症状改良维氏评分分别为1.04(±0.05)和1.03(±0.04)。复发率为 12.6%,5 年无复发生存率为 87.4%。结论腹腔镜尼森氏胃底折叠术能很好地控制典型和非典型胃食管反流症状,且复发率低,5 年无复发生存率与普遍比率相当。
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引用次数: 0
Myomectomy During the First and Second Trimesters of Pregnancy. A Therapeutic Dilemma: Report of Two Cases 妊娠头三个月和后三个月的肌瘤切除术。治疗难题:两个病例的报告
Q4 Medicine Pub Date : 2024-07-23 DOI: 10.4314/aas.v21i1.2
H. S. Diaouga, M. C. Yacouba, Rahamatou Madeleine Garba, Maina Oumara, Nafiou Id, Madi Nayama
Myomectomy during pregnancy is a rare situation, reserved for exceptional cases. We report two cases of myomectomy during  pregnancy. Case 1 was a 31-yearold primigravida with a large transmural myoma complicated by intense pelvic pain not responding to medical treatment due to red degeneration in a 6-week pregnancy. Case 2 was a 30-year-old primigravida with multiple myomas  complicated by necrosis and hydronephrosis. We performed multiple myomectomy at 17 weeks’ pregnancy after failure of medical treatment. Concerning the operative technique, we performed myomectomy during pregnancy followed by prophylactic cerclage of the  cervix. The operation is carried out as quickly as possible by the most experienced surgeon of the team, in order to shorten the operating  time and limit blood loss. Myomas that are in contact with the uterine cavity are not removed. In all, 500mg of hydroxyprogesterone was  administered intramusculary 24h before the procedure, intraoperatively, and after operation to limit the risk of abortion. In Case 1,  myomectomy was performed successfully without maternal or fetal complications. However, the patient developed placental abruption  at 33 weeks of pregnancy. The newborn died 3h after birth. In Case 2, myomectomy was complicated by a spontaneous abortion at the  end of the operation. The patient developed necrosis of the remaining myomas and endometritis leading to hysterectomy. Thus myomectomy during pregnancy should be performed as a last resort in only well-selected patients. 
妊娠期子宫肌瘤剔除术是一种罕见的手术,仅用于特殊病例。我们报告了两例妊娠期子宫肌瘤剔除术。病例 1 是一名 31 岁的初产妇,她患有一个巨大的经壁肌瘤,在怀孕 6 周时因红色变性而并发剧烈盆腔疼痛,药物治疗无效。病例 2 是一名 30 岁的初产妇,患有多发性肌瘤,并伴有坏死和肾积水。在药物治疗无效后,我们在妊娠 17 周时为她实施了多发性肌瘤切除术。在手术技术方面,我们在妊娠期进行了肌瘤切除术,然后对宫颈进行了预防性环扎。手术由团队中最有经验的外科医生尽快实施,以缩短手术时间并限制失血量。与子宫腔接触的肌瘤不会被切除。在术前 24 小时、术中和术后,均肌注 500 毫克羟孕酮,以限制流产风险。在病例 1 中,子宫肌瘤剔除术顺利完成,未出现母体或胎儿并发症。然而,患者在妊娠33周时发生了胎盘早剥。新生儿在出生 3 小时后死亡。在病例 2 中,子宫肌瘤切除术因手术结束时的自然流产而变得复杂。患者的残余肌瘤坏死,子宫内膜炎导致子宫切除。因此,只有经过严格筛选的患者才可在妊娠期进行子宫肌瘤剔除术。
{"title":"Myomectomy During the First and Second Trimesters of Pregnancy. A Therapeutic Dilemma: Report of Two Cases","authors":"H. S. Diaouga, M. C. Yacouba, Rahamatou Madeleine Garba, Maina Oumara, Nafiou Id, Madi Nayama","doi":"10.4314/aas.v21i1.2","DOIUrl":"https://doi.org/10.4314/aas.v21i1.2","url":null,"abstract":"Myomectomy during pregnancy is a rare situation, reserved for exceptional cases. We report two cases of myomectomy during  pregnancy. Case 1 was a 31-yearold primigravida with a large transmural myoma complicated by intense pelvic pain not responding to medical treatment due to red degeneration in a 6-week pregnancy. Case 2 was a 30-year-old primigravida with multiple myomas  complicated by necrosis and hydronephrosis. We performed multiple myomectomy at 17 weeks’ pregnancy after failure of medical treatment. Concerning the operative technique, we performed myomectomy during pregnancy followed by prophylactic cerclage of the  cervix. The operation is carried out as quickly as possible by the most experienced surgeon of the team, in order to shorten the operating  time and limit blood loss. Myomas that are in contact with the uterine cavity are not removed. In all, 500mg of hydroxyprogesterone was  administered intramusculary 24h before the procedure, intraoperatively, and after operation to limit the risk of abortion. In Case 1,  myomectomy was performed successfully without maternal or fetal complications. However, the patient developed placental abruption  at 33 weeks of pregnancy. The newborn died 3h after birth. In Case 2, myomectomy was complicated by a spontaneous abortion at the  end of the operation. The patient developed necrosis of the remaining myomas and endometritis leading to hysterectomy. Thus myomectomy during pregnancy should be performed as a last resort in only well-selected patients. ","PeriodicalId":37442,"journal":{"name":"Annals of African Surgery","volume":"81 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141810257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Giant Urinary Bladder Stone in Association with Acute Kidney Injury: A Rare Urological Emergency 伴有急性肾损伤的巨大膀胱结石:罕见的泌尿科急诊
Q4 Medicine Pub Date : 2024-07-23 DOI: 10.4314/aas.v20i4.3
N. Idowu, Abdul-Karim Olayinka Shitu, P. O. Odeyemi, M. W. Rasheed, Chidi Ugwuoke
Urinary stone remains a common urological disorder. Urinary bladder stone accounts for 5% of the urinary tract calculi. They are usually  small and rarely present with complications; they may progressively increase in size, occupying the urinary bladder and resulting in the development of symptoms and complications. Our aim was to report the first case of a giant urinary bladder stone in association with  severe kidney dysfunction in our Community. We report the case of a 65-year-old man with a 1-week history of decrease in urinary output and uremia following a referral from the general hospital. Remarkable findings on clinical examination were an elderly man that was  confused, pale, and dehydrated. He had a suprapubic bladder Foley catheter which was inserted at the source of referral. Laboratory and  imaging investigation revealed raised creatinine levels, bilateral hydronephrosis, and giant urinary bladder stone. These were suggestive  of obstructive uropathy likely from the stone in association with severe kidney dysfunction. He had emergency open cystolithtomy and a  400g stone was removed. There was an immediate improvement in the urinary output and renal function. We have reported our  experience on the successful management of giant urinary bladder stone in association with acute kidney injury. The patient recovered  satisfactorily from acute kidney injury following emergency open cystolithotomy. 
泌尿系统结石仍然是一种常见的泌尿系统疾病。膀胱结石占泌尿系统结石的 5%。结石通常较小,很少出现并发症;结石可能逐渐增大,占据膀胱,导致症状和并发症的出现。我们的目的是报告本社区首例伴有严重肾功能障碍的巨大膀胱结石病例。我们报告的病例是一名 65 岁的男性,经综合医院转诊后一周出现尿量减少和尿毒症。临床检查的显著发现是,老人神志不清、面色苍白、脱水。他的耻骨上膀胱插有 Foley 导管,该导尿管是在转诊时插入的。实验室和影像学检查显示肌酐水平升高、双侧肾积水和巨大膀胱结石。这表明结石很可能导致梗阻性尿病,并伴有严重的肾功能障碍。他接受了急诊开腹膀胱结石切除术,取出了 400 克的结石。尿量和肾功能立即得到改善。我们报告了成功治疗伴有急性肾损伤的巨大膀胱结石的经验。患者在急诊开放性膀胱结石切除术后从急性肾损伤中顺利康复。
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引用次数: 0
Pattern of Recurrence in Early Breast Cancer at a Tertiary Center in Sub-Saharan Africa: A Retrospective Cohort Study 撒哈拉以南非洲地区一家三级医疗中心的早期乳腺癌复发模式:回顾性队列研究
Q4 Medicine Pub Date : 2024-07-23 DOI: 10.4314/aas.v20i4.5
C. Munguti, Miriam Mutebi, Mukuhi Ng'ang'a, R. Wasike
Introduction: There is limited data on the recurrence rates and factors that contribute to recurrence in women managed for early breast  cancer in sub-Saharan Africa. This study conducted at a tertiary level facility aims to determine the recurrence rates in patients treated for early invasive breast cancer. Methods: This is a single institution retrospective cohort study of women (18–75 years) treated for early  breast cancer from 2009 to 2017. Demographic data, tumor, and treatment-related factors were summarized using descriptive statistics.  Survival analysis and Cox proportional hazard regression were performed, with computation of hazard ratios and their 95% confidence  intervals. Results: A total of 239 patients with an initial diagnosis of early breast cancer were identified. The mean age at diagnosis was 51  years (SD 13). The most prevalent molecular subtype was estrogen receptor/progesterone receptor (ER/PR)+ at 76% with only 2.9%  having human epidermal growth factor receptor 2 (HER2) overexpressing breast cancer. The overall recurrence was 7.1% with a 1.6% case mortality. The overall 5-year and 10-year survival rate was 94% and 91%, respectively. Conclusion: Early breast cancer in our setting has a  good overall survival and low recurrence rates that are comparable to that found in Western countries. 
导言:关于撒哈拉以南非洲早期乳腺癌患者的复发率和导致复发的因素的数据十分有限。本研究在一家三级医院进行,旨在确定早期浸润性乳腺癌患者的复发率。方法:这是一项单一机构的回顾性队列研究,研究对象为2009年至2017年接受早期乳腺癌治疗的女性(18-75岁)。采用描述性统计对人口统计学数据、肿瘤和治疗相关因素进行了总结。 进行了生存分析和 Cox 比例危险回归,并计算了危险比及其 95% 置信区间。结果共发现 239 名初步诊断为早期乳腺癌的患者。确诊时的平均年龄为 51 岁(SD 13)。最常见的分子亚型是雌激素受体/孕激素受体(ER/PR)+,占76%,只有2.9%的人表皮生长因子受体2(HER2)过度表达乳腺癌。总复发率为 7.1%,病例死亡率为 1.6%。5年和10年总生存率分别为94%和91%。结论在我国,早期乳腺癌的总生存率较高,复发率较低,与西方国家的情况相当。
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引用次数: 0
Bladder Outlet Obstruction: Etiological Pattern in Southwestern Nigeria 膀胱出口梗阻:尼日利亚西南部的病因学模式
Q4 Medicine Pub Date : 2023-08-07 DOI: 10.4314/aas.v20i3.3
N. Idowu, A. A. Adekunle, M. A. Adeniran, Suliat Adebisi Adeleye-Idowu
Background: Bladder outlet obstruction (BOO) is a clinical condition that is characterized by impediment to the flow of urine. It affects all age groups with varying etiologies. The pattern of this clinical condition in our setting is unknown. This study aimed at determines the clinico-epidemiological pattern of BOO in southwestern Nigeria. Method: We retrospectively reviewed the case files of patients that were managed for BOO over a period of 10years in our center. Results: A total of 784 patients were managed for BOO during the period under review. Their median age was 65.9years and in all, 486 patients of in the study group had benign prostatic hyperplasia (BPH) was the most common diagnosis followed by prostate cancer, urethral strictures and neurogenic bladder. While prostate cancer, urethral stricture, neurogenic bladder, bladder cancer, and bladder stone were diagnosed in 181, 90, 20, 5, and 2 patients, respectively. Conclusion: We have done an overview of a clinico-epidemiological pattern of BOO in southwest Nigeria is documented. The most common cause of BOO in men was while in women. It was neurogenic bladder syndrome.
背景:膀胱出口梗阻(BOO)是一种以尿流障碍为特征的临床疾病。它影响所有年龄组的不同病因。这种临床状况的模式在我们的设置是未知的。本研究旨在确定尼日利亚西南部BOO的临床流行病学模式。方法:我们回顾性地回顾了本中心10年来治疗BOO的病例档案。结果:在本研究期间,共有784例BOO患者得到了治疗。研究对象中位年龄为65.9岁,其中486例以良性前列腺增生(BPH)最为常见,其次为前列腺癌、尿道狭窄、神经源性膀胱。前列腺癌181例,尿道狭窄90例,神经源性膀胱20例,膀胱癌5例,膀胱结石2例。结论:我们对尼日利亚西南部BOO的临床流行病学模式进行了概述。男性最常见的BOO病因是女性。这是神经源性膀胱综合征。
{"title":"Bladder Outlet Obstruction: Etiological Pattern in Southwestern Nigeria","authors":"N. Idowu, A. A. Adekunle, M. A. Adeniran, Suliat Adebisi Adeleye-Idowu","doi":"10.4314/aas.v20i3.3","DOIUrl":"https://doi.org/10.4314/aas.v20i3.3","url":null,"abstract":"Background: Bladder outlet obstruction (BOO) is a clinical condition that is characterized by impediment to the flow of urine. It affects all age groups with varying etiologies. The pattern of this clinical condition in our setting is unknown. This study aimed at determines the clinico-epidemiological pattern of BOO in southwestern Nigeria. Method: We retrospectively reviewed the case files of patients that were managed for BOO over a period of 10years in our center. Results: A total of 784 patients were managed for BOO during the period under review. Their median age was 65.9years and in all, 486 patients of in the study group had benign prostatic hyperplasia (BPH) was the most common diagnosis followed by prostate cancer, urethral strictures and neurogenic bladder. While prostate cancer, urethral stricture, neurogenic bladder, bladder cancer, and bladder stone were diagnosed in 181, 90, 20, 5, and 2 patients, respectively. Conclusion: We have done an overview of a clinico-epidemiological pattern of BOO in southwest Nigeria is documented. The most common cause of BOO in men was while in women. It was neurogenic bladder syndrome.","PeriodicalId":37442,"journal":{"name":"Annals of African Surgery","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84194395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Annals of African Surgery
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