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Current Stem Cell Reports最新文献

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Human Hematopoietic Stem Cells: Concepts and Perspectives on the Biology and Use of Fresh Versus In Vitro–Generated Cells for Therapeutic Applications 人造血干细胞:生物学的概念和观点，以及新鲜细胞与体外细胞在治疗应用中的应用
IF 1.4 Q4 Biochemistry, Genetics and Molecular Biology
Current Stem Cell Reports
Pub Date : 2019-07-20 DOI: 10.1007/s40778-019-00162-1
H. Mayani
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引用次数: 4
How to Characterize Stem Cells? Contributions from Mathematical Modeling 如何描述干细胞?数学建模的贡献
IF 1.4 Q4 Biochemistry, Genetics and Molecular Biology
Current Stem Cell Reports
Pub Date : 2019-05-23 DOI: 10.1007/s40778-019-00155-0
T. Stiehl, A. Marciniak-Czochra
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引用次数: 10
Translating HSC Niche Biology for Clinical Applications 转化造血干细胞生态位生物学用于临床应用
IF 1.4 Q4 Biochemistry, Genetics and Molecular Biology
Current Stem Cell Reports
Pub Date : 2019-02-21 DOI: 10.1007/s40778-019-0152-1
T. Olson
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引用次数: 1
Non-apoptotic Roles of Caspases in Stem Cell Biology, Carcinogenesis, and Radiotherapy 半胱天冬酶在干细胞生物学、癌变和放疗中的非凋亡作用
IF 1.4 Q4 Biochemistry, Genetics and Molecular Biology
Current Stem Cell Reports
Pub Date : 2019-01-30 DOI: 10.1007/s40778-019-0151-2
R. Kaakati, Ruya Zhao, Xuhui Bao, Andrew K. Lee, Xinjian Liu, Fang Li, Chuan-Yuan Li
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引用次数: 2
Engineered Biomimetic Neural Stem Cell Niche. 工程仿生神经干细胞。
IF 1.4 Q4 Biochemistry, Genetics and Molecular Biology
Current Stem Cell Reports
Pub Date : 2019-01-01 Epub Date: 2019-05-20 DOI: 10.1007/s40778-019-00161-2
Rita Matta, Anjelica L Gonzalez

Purpose of review: Neural stem cells (NSCs) have the potential to proliferate and differentiate into functional neurons, heightening their potential use for therapeutic applications. This review explores bioengineered systems which recapitulate NSC niche cell-cell and cell-matrix interactions.

Recent findings: Delivery of NSCs to the cytotoxic injured brain is limited by low cell survival rates post-transplantation and poor maintenance of native niche bioactive components. The use of biomaterial platforms can mimic in vivo the environment of the two germinal areas of the adult brain in which NSCs thrive. An environmental mimic that includes extracellular proteins and moieties, along with appropriate biomechanical cues has recently demonstrated promising results in enhancing neurogenesis, aiding the production of a bioengineered niche.

Summary: Biocomposition, biomechanics, and biostructure can be manipulated through engineered platforms to re-create the biofunctionality of an NSC niche. Upon transplantation and delivery with biomimetic scaffolds, NSCs show potential to promote functional recovery and rebuild neural circuitry post neurological trauma.

综述目的：神经干细胞（NSCs）具有增殖和分化为功能性神经元的潜力，提高了其治疗应用的潜在用途。这篇综述探讨了再现神经干细胞龛细胞-细胞和细胞-基质相互作用的生物工程系统：向细胞毒性损伤的大脑输送 NSCs 受到移植后细胞存活率低和原生龛生物活性成分维持不良的限制。使用生物材料平台可以在体内模拟成体大脑两个发芽区的环境，NSCs就在这两个发芽区茁壮成长。包括细胞外蛋白质和分子以及适当的生物力学线索在内的环境模拟物最近在增强神经发生方面取得了可喜的成果，有助于生物工程龛的产生。摘要：生物构成、生物力学和生物结构可通过工程平台进行操作，以重新创建 NSC 龛的生物功能。在使用仿生支架进行移植和输送后，NSCs 显示出促进功能恢复和重建神经创伤后神经回路的潜力。
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引用次数: 0
Peripheral blood stem cell mobilization; a look ahead. 外周血干细胞动员；展望未来。
IF 1.4 Q4 Biochemistry, Genetics and Molecular Biology
Current Stem Cell Reports
Pub Date : 2018-12-01 Epub Date: 2018-10-23 DOI: 10.1007/s40778-018-0141-9
Louis M Pelus, Hal E Broxmeyer

The purpose of review: Mobilized peripheral blood is the predominant source of stem and progenitor cells for hematologic transplantation. Successful transplant requires sufficient stem cells of high enough quality to recapitulate lifelong hematopoiesis, but in some patients and normal donors, reaching critical threshold stem cell numbers are difficult to achieve. Novel strategies, particularly those offering rapid mobilization and reduced costs, remains an area of interest.This review summarizes critical scientific underpinnings in understanding the process of stem cell mobilization, with a focus on new or improved strategies for their efficient collection and engraftment.

Recent findings: Studies are described that provide new insights into the complexity of stem cell mobilization. Agents that target new pathways such HSC egress, identify strategies to collect more potent competing HSC and new methods to optimize stem cell collection and engraftment are being evaluated.

Summary: Agents and more effective strategies that directly address the current shortcomings of hematopoietic stem cell mobilization and transplantation and offer the potential to facilitate collection and expand use of mobilized stem cells have been identified.

综述的目的：动员的外周血是血液移植干细胞和祖细胞的主要来源。成功的移植需要足够高质量的干细胞来恢复终身造血，但在一些患者和正常捐献者中，很难达到临界干细胞数量。新的战略，特别是那些提供快速动员和降低成本的战略，仍然是一个令人感兴趣的领域。这篇综述总结了理解干细胞动员过程的关键科学基础，重点是有效收集和移植干细胞的新策略或改进策略。最近的发现：研究为干细胞动员的复杂性提供了新的见解。针对HSC排出等新途径的试剂，确定收集更有力的竞争性HSC的策略，以及优化干细胞收集和移植的新方法正在评估中。摘要：已经确定了直接解决目前造血干细胞动员和移植不足的药物和更有效的策略，并有可能促进动员干细胞的收集和扩大使用。
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引用次数: 24
Mini Review: Application of Human Mesenchymal Stem Cells in Gene and Stem Cells Therapy Era 人间充质干细胞在基因和干细胞治疗时代的应用综述
IF 1.4 Q4 Biochemistry, Genetics and Molecular Biology
Current Stem Cell Reports
Pub Date : 2018-11-09 DOI: 10.1007/s40778-018-0147-3
R. Deng, A. H. Law, Jia-Juan Shen, G. C. Chan
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引用次数: 2
Novel Cellular Therapeutic Approaches for the Prevention and Management of Graft-Versus-Host Disease 预防和治疗移植物抗宿主病的新细胞治疗方法
IF 1.4 Q4 Biochemistry, Genetics and Molecular Biology
Current Stem Cell Reports
Pub Date : 2018-10-31 DOI: 10.1007/s40778-018-0146-4
S. Jauhari, N. Chao
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引用次数: 0
Editing the Genome Ex Vivo Stem Cell Therapy 编辑基因组的体外干细胞治疗
IF 1.4 Q4 Biochemistry, Genetics and Molecular Biology
Current Stem Cell Reports
Pub Date : 2018-10-16 DOI: 10.1007/s40778-018-0148-2
Yiping Fan, J. Chan
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引用次数: 1
Induced Pluripotent Stem Cell-Derived Red Blood Cells, Megakaryocytes, and Platelets: Progress and Challenges 诱导多能干细胞衍生的红细胞、巨核细胞和血小板:进展和挑战
IF 1.4 Q4 Biochemistry, Genetics and Molecular Biology
Current Stem Cell Reports
Pub Date : 2018-10-12 DOI: 10.1007/s40778-018-0144-6
H. An, M. Poncz, S. Chou
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引用次数: 7
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